Basic Information

Email Address

• Email Address

  konishi.satoshi.3hkyoto-u.ac.jp

Academic Degree

• 23 Mar. 2016

  京都大学博士（医学）

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

Research History

• From Dec. 2023, To Present

  京都大学iPS細胞研究所, 臨床応用研究部門 後藤研究室, 特定拠点助教
• From Jan. 2020, To Nov. 2023

  Duke University, Department of Cell Biology, Postdoctoral Associate
• From Apr. 2016, To Mar. 2020

  Kyoto University, Faculty of Medicine Department of Respiratory Medicine, Visiting Researcher
• From Apr. 2019, To Jan. 2020

  Japanese Red Cross Wakayama Medical Center, Department of Respiratory Medicine, Respiratory Physician
• From Apr. 2019, To Jan. 2020

  Osaka University, Graduate School of Frontier Biosciences, Project Lecturer
• From Sep. 2015, To Mar. 2019

  Osaka University, Graduate School of Frontier Biosciences, Project researcher
• From Apr. 2009, To Mar. 2012

  Kurashiki Central Hospital, Department of Respiratory Medicine, Senior Resident
• From Apr. 2007, To Mar. 2009

  Kurashiki Central Hsopital, Internal Medicine, Junior Resident

ID,URL

• ORCID ID

  0000-0002-3265-7491

• J-Global ID

  201801008419438374

• Researcher number

  10789564

researchmap URL

• https://researchmap.jp/ksatoshi

Research

Research Interests

• alveolar regeneration
• lung disease modeling
• multi-ciliary coordination
• cytoskeletal dynamics
• primary culture of airway/alveolar epithelial cells
• human induced pluripotent stem cells
• super-resolution microscopic study
• live-cell imaging
• animal lung injury model

Research Areas

• Life sciences, Respiratory medicine
• Life sciences, Cell biology

Papers

• Development of Myeloperoxidase Anti-neutrophil Cytoplasmic Antibody-positive Necrotizing Crescentic Glomerulonephritis in an Elderly Patient with Immunological Kidney Disease.

  Yoshida H; Takahashi N; Horiguchi T; Yasuhara H; Tanaka T; Chen Y; Takasaki T; Tsukao H; Yoshida M; Kawakami S; Ohta M; Naiki H; Konishi S; Ito I; Iwano M

  Internal medicine (Tokyo, Japan), 19 Jun. 2021

  
• Investigation of predictors for in-hospital death or long-term hospitalization in community-acquired pneumonia with risk factors for aspiration

  Issei Oi; Isao Ito; Naoya Tanabe; Satoshi Konishi; Yumiko Ibi; Yu Hidaka; Nobuyoshi Hamao; Masahiro Shirata; Kensuke Nishioka; Seiichiro Imai; Yoshiro Yasutomo; Seizo Kadowaki; Toyohiro Hirai

  European Clinical Respiratory Journal, 04 Apr. 2024, Peer-reviewed

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• Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons

  Gen Shiratsuchi; Satoshi Konishi; Tomoki Yano; Yuichi Yanagihashi; Shogo Nakayama; Tatsuya Katsuno; Hiroka Kashihara; Hiroo Tanaka; Kazuto Tsukita; Koya Suzuki; Elisa Herawati; Hitomi Watanabe; Toyohiro Hirai; Takeshi Yagi; Gen Kondoh; Shimpei Gotoh; Atsushi Tamura; Sachiko Tsukita

  EMBO Reports, 05 Feb. 2024, Peer-reviewed, Lead author

  
• Transitional cell states sculpt tissue topology during lung regeneration

  Arvind Konkimalla; Satoshi Konishi; Lauren Macadlo; Yoshihiko Kobayashi; Zachary J. Farino; Naoya Miyashita; Léa El Haddad; Jeremy Morowitz; Christina E. Barkauskas; Pankaj Agarwal; Tomokazu Souma; Mai K. ElMallah; Aleksandra Tata; Purushothama Rao Tata

  Cell Stem Cell, Nov. 2023, Peer-reviewed, Lead author

  
• Efficient AAV Mediated Transgenesis in Alveolar Stem Cells and Associated Niches.

  Arvind Konkimalla; Zachary Elmore; Satoshi Konishi; Lauren Macadlo; Hiroaki Katsura; Aleksandra Tata; Aravind Asokan; Purushothama Rao Tata

  American journal of respiratory cell and molecular biology, 14 Jun. 2023, Peer-reviewed

  
• Protein C activity as a potential prognostic factor for nursing home-acquired pneumonia

  Issei Oi; Isao Ito; Naoya Tanabe; Satoshi Konishi; Nobuyoshi Hamao; Masahiro Shirata; Seiichiro Imai; Yoshiro Yasutomo; Seizo Kadowaki; Hisako Matsumoto; Yu Hidaka; Satoshi Morita; Toyohiro Hirai

  PLOS ONE, 12 Oct. 2022, Peer-reviewed

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• Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration

  Arvind Konkimalla; Satoshi Konishi; Yoshihiko Kobayashi; Preetish Kadur Lakshminarasimha Murthy; Lauren Macadlo; Ananya Mukherjee; Zachary Elmore; So-Jin Kim; Ann Marie Pendergast; Patty J. Lee; Aravind Asokan; Lars Knudsen; Jose Javier Bravo-Cordero; Aleksandra Tata; Purushothama Rao Tata

  iScience, Sep. 2022, Peer-reviewed

  
• Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures

  Satoshi Konishi; Aleksandra Tata; Purushothama Rao Tata

  STAR Protocols, Jun. 2022, Peer-reviewed, Lead author

  
• Development and validation of a new scoring system for prognostic prediction of community-acquired pneumonia in older adults.

  Masahiro Shirata; Isao Ito; Tadashi Ishida; Hiromasa Tachibana; Naoya Tanabe; Satoshi Konishi; Issei Oi; Nobuyoshi Hamao; Kensuke Nishioka; Hisako Matsumoto; Yoshiro Yasutomo; Seizo Kadowaki; Hisashi Ohnishi; Hiromi Tomioka; Takashi Nishimura; Yoshinori Hasegawa; Atsushi Nakagawa; Toyohiro Hirai

  Scientific reports, 13 Dec. 2021, Peer-reviewed

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• Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology

  Naoyuki Sone; Satoshi Konishi; Koichi Igura; Koji Tamai; Satoshi Ikeo; Yohei Korogi; Shuhei Kanagaki; Toshinori Namba; Yuki Yamamoto; Yifei Xu; Kazuhiko Takeuchi; Yuichi Adachi; Toyofumi F. Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Sachiko Tsukita; Toyohiro Hirai; Yu-suke Torisawa; Shimpei Gotoh

  Science Translational Medicine, 07 Jul. 2021, Peer-reviewed

  
• Planar cell polarity induces local microtubule bundling for coordinated ciliary beating

  Shogo Nakayama; Tomoki Yano; Toshinori Namba; Satoshi Konishi; Maki Takagishi; Elisa Herawati; Tomoki Nishida; Yasuo Imoto; Shuji Ishihara; Masahide Takahashi; Ken’ya Furuta; Kazuhiro Oiwa; Atsushi Tamura; Sachiko Tsukita

  Journal of Cell Biology, 05 Jul. 2021, Peer-reviewed

  
• Risk factors associated with methicillin-resistant Staphylococcus aureus isolation from serially collected sputum samples of patients hospitalized with pneumonia

  Masahiro Shirata; Isao Ito; Naoya Tanabe; Satoshi Konishi; Issei Oi; Nobuyoshi Hamao; Hisako Matsumoto; Yoshiro Yasutomo; Seizo Kadowaki; Toyohiro Hirai

  Journal of Infection and Chemotherapy, May 2021, Peer-reviewed

  
• Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial.

  Nobuyoshi Hamao; Isao Ito; Satoshi Konishi; Naoya Tanabe; Masahiro Shirata; Issei Oi; Mitsuhiro Tsukino; Hisako Matsumoto; Yoshiro Yasutomo; Seizo Kadowaki; Toyohiro Hirai

  BMC pulmonary medicine, 05 Jun. 2020, Peer-reviewed

  
• Cefepime vs. meropenem for moderate-to-severe pneumonia in patients at risk for aspiration: An open-label, randomized study

  Issei Oi; Isao Ito; Naoya Tanabe; Satoshi Konishi; Nobuyoshi Hamao; Yoshiro Yasutomo; Seizo Kadowaki; Toyohiro Hirai

  Journal of Infection and Chemotherapy, Feb. 2020, Peer-reviewed

  
• Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.

  Satoshi Konishi; Tomoki Yano; Hiroo Tanaka; Tomoaki Mizuno; Hatsuho Kanoh; Kazuto Tsukita; Toshinori Namba; Atsushi Tamura; Shigenobu Yonemura; Shimpei Gotoh; Hisako Matsumoto; Toyohiro Hirai; Sachiko Tsukita

  Life science alliance, Aug. 2019, Peer-reviewed, Lead author

  
• In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.

  Yohei Korogi; Shimpei Gotoh; Satoshi Ikeo; Yuki Yamamoto; Naoyuki Sone; Koji Tamai; Satoshi Konishi; Tadao Nagasaki; Hisako Matsumoto; Isao Ito; Toyofumi F Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Isao Asaka; Akitsu Hotta; Michiaki Mishima; Toyohiro Hirai

  Stem cell reports, 09 Jul. 2019, Peer-reviewed

  
• In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.

  Korogi Y; Gotoh S; Ikeo S; Yamamoto Y; Sone N; Tamai K; Konishi S; Nagasaki T; Matsumoto H; Ito I; Chen-Yoshikawa TF; Date H; Hagiwara M; Asaka I; Hotta A; Mishima M; Hirai T

  Stem Cell Reports, Mar. 2019, Peer-reviewed

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• Isolation of ESBL-producing bacteria from sputum in community-acquired pneumonia or healthcare-associated pneumonia does not indicate the need for antibiotics with activity against this class

  Hideyuki Horie; Isao Ito; Satoshi Konishi; Yuki Yamamoto; Yuko Yamamoto; Tatsuya Uchida; Hideo Ohtani; Yoshiharu Yoshida

  Internal Medicine, 2018, Peer-reviewed

  
• Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

  Yuki Yamamoto; Shimpei Gotoh; Yohei Korogi; Masahide Seki; Satoshi Konishi; Satoshi Ikeo; Naoyuki Sone; Tadao Nagasaki; Hisako Matsumoto; Shigeo Muro; Isao Ito; Toyohiro Hirai; Takashi Kohno; Yutaka Suzuki; Michiaki Mishima

  NATURE METHODS, Nov. 2017, Peer-reviewed

  
• Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

  Satoshi Konishi; Shimpei Gotoh; Kazuhiro Tateishi; Yuki Yamamoto; Yohei Korogi; Tadao Nagasaki; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Isao Ito; Sachiko Tsukita; Michiaki Mishima

  STEM CELL REPORTS, Jan. 2016, Peer-reviewed, Lead author

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• Composite Physiologic Index, Percent Forced Vital Capacity and Percent Diffusing Capacity for Carbon Monoxide Could Be Predictors of Pirfenidone Tolerability in Patients with Idiopathic Pulmonary Fibrosis

  Satoshi Konishi; Machiko Arita; Isao Ito; Hiromasa Tachibana; Takuya Takaiwa; Yasushi Fukuda; Naoki Watanabe; Kazuya Tsubouchi; Gen Masuda; Maki Tanaka; Youhei Kourogi; Kei Kunimasa; Akihiro Nishiyama; Masahiro Iwasaku; Akihiro Ito; Fumiaki Tokioka; Hiroshige Yoshioka; Toru Hashimoto; Tadashi Ishida

  INTERNAL MEDICINE, 2015, Peer-reviewed, Lead author

  
• Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

  Shimpei Gotoh; Isao Ito; Tadao Nagasaki; Yuki Yamamoto; Satoshi Konishi; Yohei Korogi; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Michinori Funato; Shin-Ichi Mae; Taro Toyoda; Aiko Sato-Otsubo; Seishi Ogawa; Kenji Osafune; Michiaki Mishima

  STEM CELL REPORTS, Sep. 2014, Peer-reviewed

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• The Clinical Characteristics of Two Anti-OJ (Anti-Isoleucylt-RNA Synthetase) Autoantibody-Positive Interstitial Lung Disease Patients with Polymyositis/Dermatomyositis

  Kei Kunimasa; Machiko Arita; Takashi Nakazawa; Maki Tanaka; Kazuya Tsubouchi; Satoshi Konishi; Yasushi Fukuda; Mika Saigusa; Hiroaki Nakagawa; Satoshi Ubukata; Yohei Korogi; Takao Fujii; Tsuneyo Mimori; Tadashi Ishida

  INTERNAL MEDICINE, 2012, Peer-reviewed

  

Misc.

• 肺のオルガノイド化とその医学応用への可能性─呼吸器における幹細胞研究の新展開

  小西聡史; 後藤慎平

  医学のあゆみ, Feb. 2018

  
• Generation of Airway Epithelial Cells from Human Induced Pluripotent Stem Cells

  小西 聡史; 後藤 慎平

  呼吸と循環, Aug. 2016

  

Presentations

• 微小管の束化が呼吸器再生における肺胞上皮細胞の三次元形態変化を制御する

  小西 聡史

  第97回 日本生化学会大会 「シンポジウム：上皮管腔組織のダイナミクスと恒常性の制御機構」, 07 Nov. 2024, Invited

  
• Ex vivo培養系及びin vivo障害モデルを用いた呼吸器再生メカニズムの探求

  小西聡史

  第5回「医学と数理」研究会, 29 Sep. 2024, Invited

  
• Ex vivo四次元イメージングを用いた呼吸器組織再生メカニズムの探求

  小西 聡史

  第40回 日本DDS学会学術集会 「シンポジウム：DDS研究のためのex vivo三次元組織形成技術」, 10 Jul. 2024, Invited

  
• 一過性に出現する遷移的な細胞状態が肺胞再生における組織再構築を規定する

  小西 聡史

  第64回 日本呼吸器学会学術講演会 「若手呼吸器研究最前線シンポジウム」, 05 Apr. 2024

  
• 高解像ライブセルイメージングによる気道多繊毛協調運動構築原理の解明

  小西聡史; 矢野智樹; 難波利典; Franco Fermin; 加納初穂; Elisa Herawati; 柏原 宏香; 中山 彰吾; 谷口大介; 田中 啓雄; 月田和人; 後藤 慎平; 平井豊博; 石原秀至; 田村 淳; 月田 早智子

  第92回 日本生化学会大会 「シンポジウム：細胞の上皮性を決定・維持する多面的な分子機構」, 19 Sep. 2019

  
• ヒトiPS細胞から機能的な気道線毛上皮細胞への分化誘導

  小西 聡史; 後藤慎平; 立石和博; 山本佑樹; 興梠陽平; 長崎忠雄; 松本久子; 室繁郎; 平井豊博; 伊藤功朗; 月田早智子; 三嶋理晃

  第56回 日本呼吸器学会学術講演会 「ミニシンポジウム：肺細胞の分化・機能の新知見」, 08 Apr. 2016

  

Industrial Property Rights

• 特願2020-081522, 多列繊毛気道上皮細胞、分化誘導法および製造方法

  後藤慎平; 曽根尚之; 小西聡史; 鳥澤勇介; 難波利典; 山本祐樹; 月田早智子

  
• 特許6738572, 特願2015-045298, 肺胞上皮細胞の分化誘導法

  後藤慎平; 山本祐樹; 小西聡史; 三嶋理晃

  
• 特許6730709, 特願2015-056791, 気道上皮細胞の分化誘導法

  後藤慎平; 小西聡史; 山本祐樹; 三嶋理晃

  

Awards

• 27 Feb. 2017

  第8回　若手研究フォーラム　ベストプレゼンテーション賞（大阪大学）
• 18 Sep. 2017

  京都大学医学部若手研究者優秀論文賞KMYIA
• 14 Sep. 2022

  Duke University Department of Cell Biology Retreat Best Microscopic image award
• 20 Feb. 2016

  NPO法人西日本呼吸器内科推進機構　第10回研究部門奨励賞
• 23 Apr. 2010

  第50回　日本呼吸器学会学術講演会トラベルアワード

External funds: Kakenhi

• 精密切断肺スライス培養を用いた遷移性幹細胞状態の蓄積による肺線維症誘導機構の解明

  Grant-in-Aid for Research Activity Start-up

  0803:Pathology, infection/immunology, and related fields

  Kyoto University

  小西 聡史

  From 31 Jul. 2024, To 31 Mar. 2026, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K23312/
• The establishment of intercellular co-ordination of ciliary movement by using human iPS cell-derived airway epithelial cells

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  Satoshi Konishi

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  多繊毛協調運動;粘液繊毛クリアランス;気道疾患モデリング;ヒトiPS細胞;初代培養マウス気管上皮細胞;ライブセルイメージング;気道繊毛上皮細胞;超解像顕微鏡;平面極性コア蛋白;アピカル細胞骨格;疾患モデルiPS細胞;繊毛上皮細胞;気道上皮細胞;細胞間の繊毛協調運動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K17853/
• Elucidation of the pulmonary fibrosis pathogenesis mediated by the accumulation of the transitional stem cell state using precision cut lung slice culture

  Grant-in-Aid for Research Activity Start-up

  0803:Pathology, infection/immunology, and related fields

  Kyoto University

  小西 聡史

  From 31 Jul. 2024, To 31 Mar. 2026, Granted

  特発性肺線維症;肺胞上皮幹細胞の移行状態;精密切断肺スライス培養;ヒトiPS細胞由来肺胞上皮細胞;時空間オミクス解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K23312/