Basic Information

Faculty

• Faculty of Medicine

Academic Degree

• 博士（医学）(京都大学)

Research History

• From Jun. 2023, To Present

  Kyoto University, Center for Cancer Immunotherapy and Immunobiology, Associate Professor
• From Jul. 2020, To Jun. 2023

  Kyoto University Hospital, Clinical Oncology, Assistant Professor
• From Jan. 2020, To Jul. 2020

  Kyoto University Hospital, Clinical Bio-Resource Center, Assistant Professor
• From Oct. 2019, To Jan. 2020

  Kyoto University Hospital, Clinical Oncology, Attending physician
• From Oct. 2016, To Sep. 2019

  Dana-Farber Cancer Institute, Medical Oncology, Postdoctral Fellow

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  202001004572466622

researchmap URL

• https://researchmap.jp/10869366

Research

Research Topics, Overview of the research

• Research Topics

  R&D for GI malignancies

• Overview of the research

  Developing molecular targeted therapies using novel technologies such as the genome-wide CRISPR screening.

Research Areas

• Life sciences, Tumor diagnostics and therapeutics

Papers

• Delayed CD4 +T-cell response in older adults is associated with reduced immunogenicity and reactogenicity after COVID-19 mRNA vaccination

  Norihide Jo; Yu Hidaka; Osamu Kikuchi; Masaru Fukahori; Takeshi Sawada; Masahiko Aoki; Masaki Yamamoto; Miki Nagao; Satoshi Morita; Takako E Nakajima; Manabu Muto; Yoko Hamazaki

  The Journal of Immunology, 01 May 2023, Peer-reviewed

  
• Effect of pre-vaccination blood and T-cell phenotypes on antibody responses to COVID-19 mRNA vaccine

  Yu Hidaka; Norihide Jo; Osamu Kikuchi; Masaru Fukahori; Takeshi Sawada; Yutaka Shimazu; Masaki Yamamoto; Kohei Kometani; Miki Nagao; Takako E Nakajima; Manabu Muto; Satoshi Morita; Yoko Hamazaki

  International Immunology, 20 Mar. 2025, Peer-reviewed

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• Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization

  Yuki Kondo; Shinya Ohashi; Chikatoshi Katada; Yukie Nakai; Yoshihiro Yamamoto; Masashi Tamaoki; Osamu Kikuchi; Atsushi Yamada; Kenshiro Hirohashi; Yosuke Mitani; Shigeki Kataoka; Tomoki Saito; Trang H. Nguyen Vu; Tomohiro Kondo; Yu Uneno; Tomohiko Sunami; Akira Yokoyama; Junichi Matsubara; Tomonari Matsuda; Seiji Naganuma; Kohei Oryu; Samuel Flashner; Masataka Shimonosono; Hiroshi Nakagawa; Manabu Muto

  Journal of Gastroenterology, 06 Feb. 2025, Peer-reviewed

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• Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults.

  Kohei Kometani; Takaaki Yorimitsu; Norihide Jo; Erina Yamaguchi; Osamu Kikuchi; Masaru Fukahori; Takeshi Sawada; Yoshitaka Tsujimoto; Ayana Sunami; Mengqian Li; Takeshi Ito; Yann Pretemer; Yuxian Gao; Yu Hidaka; Masaki Yamamoto; Natsuko Kaku; Yu Nakagama; Yasutoshi Kido; Alba Grifoni; Alessandro Sette; Miki Nagao; Satoshi Morita; Takako E Nakajima; Manabu Muto; Yoko Hamazaki

  Frontiers in immunology, 2024, Peer-reviewed

  
• 食道扁平上皮癌の生物進化(Evolutionary Biology of esophageal squamous cell carcinoma)

  横山 顕礼; 平野 智紀; 石田 雄大; 菊池 理; 竹内 康英; 南口 早智子; 小川 誠司; 武藤 学; 垣内 伸之

  日本癌学会総会記事, Sep. 2023

  
• Colorectal cancer harboring EGFR kinase domain duplication response to EGFR tyrosine kinase inhibitors.

  Tomohiro Kondo; Osamu Kikuchi; Yoshihiro Yamamoto; Tomohiko Sunami; Yafeng Wang; Keita Fukuyama; Tomoki Saito; Hideto Nakahara; Sachiko Minamiguchi; Masashi Kanai; Atsushi Sueyoshi; Manabu Muto

  The oncologist, 31 May 2024, Peer-reviewed

  
• Developing SHP2-based combination therapy for KRAS-amplified cancer

  Tianxia Li; Osamu Kikuchi; Jin Zhou; Yichen Wang; Babita Pokharel; Klavdija Bastl; Prafulla Gokhale; Aine Knott; Yanxi Zhang; John G. Doench; Zandra V. Ho; Daniel V.T. Catenacci; Adam J. Bass

  JCI Insight, 08 Feb. 2023, Lead author

  
• Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin.

  Tomoyuki Abe; Yoshihito Horisawa; Osamu Kikuchi; Hitomi Ozawa-Umeta; Atsuhiro Kishimoto; Yasuhiro Katsuura; Atsushi Imaizumi; Tadashi Hashimoto; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kosuke Yusa; Tadashi Asakura; Hideaki Kakeya; Masashi Kanai

  European journal of pharmacology, 15 Nov. 2022, Peer-reviewed

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• 生活習慣病としての逆流性食道炎の病因解析

  大橋 真也; 丸野 貴久; 福山 啓太; 坂本 容子; 菊池 理; 今井 誠一郎; 山田 敦; 妹尾 浩; 武藤 学; 井上 真由美

  日本内科学会雑誌, Feb. 2022

  
• Multicenter phase II study of trifluridine/tipiracil for esophageal squamous carcinoma refractory/intolerant to 5-fluorouracil, platinum compounds, and taxanes: the ECTAS study.

  Yukiko Mori; Osamu Kikuchi; Takahiro Horimatsu; Hiroki Hara; Shuichi Hironaka; Takashi Kojima; Ken Kato; Takahiro Tsushima; Ryu Ishihara; Kumi Mukai; Ryuji Uozumi; Harue Tada; Hiroi Kasai; Atsushi Kawaguchi; Manabu Muto

  Esophagus : official journal of the Japan Esophageal Society, 20 Jan. 2022

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• Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma

  Trang H. Nguyen Vu; Osamu Kikuchi; Shinya Ohashi; Tomoki Saito; Tomomi Ida; Yukie Nakai; Yang Cao; Yoshihiro Yamamoto; Yuki Kondo; Yosuke Mitani; Shigeki Kataoka; Tomohiro Kondo; Chikatoshi Katada; Atsushi Yamada; Junichi Matsubara; Manabu Muto

  Cancer Science, 19 Sep. 2023, Peer-reviewed

  
• Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect.

  Kiichiro Baba; Motoo Nomura; Shinya Ohashi; Takuya Hiratsuka; Yukie Nakai; Tomoki Saito; Yuki Kondo; Keita Fukuyama; Osamu Kikuchi; Atsushi Yamada; Junichi Matsubara; Kenshiro Hirohashi; Yosuke Mitani; Ayaka Mizumoto; Manabu Muto

  American journal of cancer research, 2020, Peer-reviewed

  
• Impaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination

  Norihide Jo; Yu Hidaka; Osamu Kikuchi; Masaru Fukahori; Takeshi Sawada; Masahiko Aoki; Masaki Yamamoto; Miki Nagao; Satoshi Morita; Takako E. Nakajima; Manabu Muto; Yoko Hamazaki

  Nature Aging, 12 Jan. 2023, Peer-reviewed

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• [Marked effect of combination chemotherapy with tegafur-gimeracil-oteracil potassium and gemcitabine on a suspected case of pancreas cancer or gallbladder cancer metastasis to bone: further diagnosis of disseminated carcinomatosa of bone marrow recurrence after the 23 years of gastric cancer operation by autopsy findings].

  Akihiro Sakai; Yoshihisa Tsuji; Osamu Kikuchi; Akiko Jinno; Wataru Tanabe; Yoshihiko Terashima; Yuki Maeda; Akira Doi; Takako Hata; Naoki Yamamoto; Ikuo Aoyama; Osamu Arai; Yoshie Kiyosuke; Sachiko Katayama; Ken Hirao; Masatsugu Miyoshi; Hirokazu Mouri; Kazuhiro Matsueda; Hiroshi Yamamoto

  Gan to kagaku ryoho. Cancer & chemotherapy, Mar. 2008, Peer-reviewed

  
• Serum microRNAs as diagnostic biomarkers for early colorectal neoplasms

  Atsushi Yamada; Takahiro Horimatsu; Yoshinaga Okugawa; Naoshi Nishida; Tadayuki Kou; Toshihiro Kusaka; Hajime Honjo; Yusuke Amanuma; Osamu Kikuchi; Manabu Muto; Ajay Goel; C. Richard Boland

  CANCER RESEARCH, Oct. 2014, Peer-reviewed

  
• HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function.

  Yosuke Mitani; Shinya Ohashi; Osamu Kikuchi; Yukie Nakai; Tomomi Ida; Ayaka Mizumoto; Yoshihiro Yamamoto; Tomoki Saito; Shigeki Kataoka; Junichi Matsubara; Atsushi Yamada; Masashi Kanai; Shigemi Matsumoto; Hiroaki Sakai; Kiyotsugu Yoshikawa; Eijiro Nakamura; Manabu Muto

  Scientific reports, 02 Jun. 2022, Peer-reviewed

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• [Research Support at the Clinical Bioresource Center in Kyoto University Hospital].

  Manabu Muto; Osamu Kikuchi; Masashi Kanai; Shigemi Matsumoto; Hiromitsu Tazawa; Masato Tanaka; Mayumi Inoue

  Gan to kagaku ryoho. Cancer & chemotherapy, Feb. 2022

  
• Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40–69-years subjects

  Shinya Ohashi; Takahisa Maruno; Keita Fukuyama; Osamu Kikuchi; Tomohiko Sunami; Yuki Kondo; Seiichiro Imai; Aki Matsushima; Kazuyo Suzuki; Fumika Usui; Masahiro Yakami; Atsushi Yamada; Hiroyoshi Isoda; Shigemi Matsumoto; Hiroshi Seno; Manabu Muto; Mayumi Inoue

  Esophagus, 12 Jun. 2021

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• Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma

  Shinya Ohashi; Osamu Kikuchi; Yukie Nakai; Tomomi Ida; Tomoki Saito; Yuki Kondo; Yoshihiro Yamamoto; Yosuke Mitani; Trang H. Nguyen Vu; Keita Fukuyama; Hiroshi Tsukihara; Norihiko Suzuki; Manabu Muto

  Molecular cancer therapeutics, 01 Jun. 2020, Peer-reviewed

  
• Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice

  Kenshiro Hirohashi; Shinya Ohashi; Yusuke Amanuma; Yukie Nakai; Tomomi Ida; Kiichiro Baba; Yosuke Mitani; Ayaka Mizumoto; Yoshihiro Yamamoto; Osamu Kikuchi; Junichi Matsubara; Atsushi Yamada; Shin'ichi Miyamoto; Hiroshi Seno; Tomonari Matsuda; Manabu Muto

  Carcinogenesis, Apr. 2020, Peer-reviewed

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• Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model

  Nilay S. Sethi; Osamu Kikuchi; Gina N. Duronio; Matthew D. Stachler; James M. McFarland; Ruben Ferrer-Luna; Yanxi Zhang; Chunyang Bao; Roderick Bronson; Deepa Patil; Francisco Sanchez-Vega; Jie-Bin Liu; Ewa Sicinska; Jean-Bernard Lazaro; Keith L. Ligon; Rameen Beroukhim; Adam J. Bass

  Nature Genetics, 05 Feb. 2020, Peer-reviewed

  
• Genomics and Targeted Therapies in Gastroesophageal Adenocarcinoma

  Ankur K. Nagaraja; Osamu Kikuchi; Adam J. Bass

  Cancer Discovery, 01 Dec. 2019, Peer-reviewed

  
• Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma

  Nilay Sethi; Osamu Kikuchi; James McFarland; Yanxi Zhang; Max Chung; Nicholas Kafker; Mirazul Islam; Benjamin Lampson; Abhishek Chakraborty; William G. Kaelin; Adam J. Bass

  JCI Insight, 08 Aug. 2019, Peer-reviewed, Lead author

  
• Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma

  Ayaka Mizumoto; Shinya Ohashi; Mayumi Kamada; Tomoki Saito; Yukie Nakai; Kiichiro Baba; Kenshiro Hirohashi; Yosuke Mitani; Osamu Kikuchi; Junichi Matsubara; Atsushi Yamada; Tsukasa Takahashi; Hyunjin Lee; Yasushi Okuno; Masashi Kanai; Manabu Muto

  Journal of Gastroenterology, 05 Aug. 2019, Peer-reviewed

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• Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells

  Takashi Kijima; Hiroshi Nakagawa; Masataka Shimonosono; Prasanna M. Chandramouleeswaran; Takeo Hara; Varun Sahu; Yuta Kasagi; Osamu Kikuchi; Koji Tanaka; Veronique Giroux; Amanda B. Muir; Kelly A. Whelan; Shinya Ohashi; Seiji Naganuma; Andres J. Klein-Szanto; Yoshiaki Shinden; Ken Sasaki; Itaru Omoto; Yoshiaki Kita; Manabu Muto; Adam J. Bass; J. Alan Diehl; Gregory G. Ginsberg; Yuichiro Doki; Masaki Mori; Yasuto Uchikado; Takaaki Arigami; Narayan G. Avadhani; Devraj Basu; Anil K. Rustgi; Shoji Natsugoe

  Cellular and Molecular Gastroenterology and Hepatology, 2019, Peer-reviewed

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• Early diagnosis of pancreatic necrosis based on perfusion CT to predict the severity of acute pancreatitis

  Yoshihisa Tsuji; Naoki Takahashi; Hiroyoshi Isoda; Koji Koizumi; Sho Koyasu; Miho Sekimoto; Yuichi Imanaka; Shujiro Yazumi; Masanori Asada; Yoshihiro Nishikawa; Hiroshi Yamamoto; Osamu Kikuchi; Tsukasa Yoshida; Tetsuro Inokuma; Shinji Katsushima; Naoki Esaka; Akihiro Okano; Chiharu Kawanami; Nobuyuki Kakiuchi; Masahiro Shiokawa; Yuzo Kodama; Ichiro Moriyama; Takafumi Kajitani; Yoshikazu Kinoshita; Tsutomu Chiba

  Journal of gastroenterology, 01 Oct. 2017, Peer-reviewed

  
• Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells

  Masahiro Yoshioka; Shinya Ohashi; Tomomi Ida; Yukie Nakai; Osamu Kikuchi; Yusuke Amanuma; Junichi Matsubara; Atsushi Yamada; Shin'Ichi Miyamoto; Mitsuteru Natsuizaka; Hiroshi Nakagawa; Tsutomu Chiba; Hiroshi Seno; Manabu Muto

  Journal of Experimental and Clinical Cancer Research, 01 Aug. 2017, Peer-reviewed

  
• Factors affecting dilation force in balloon dilation of severe esophageal strictures: an experiment using an artificial stricture model

  Yoshitaka Nishikawa; Hirokazu Higuchi; Osamu Kikuchi; Yasumasa Ezoe; Ikuo Aoyama; Atsushi Yamada; Masataka Kanki; Shuhei Nomura; Motoo Nomura; Takahiro Horimatsu; Manabu Muto

  Surgical Endoscopy, 01 Oct. 2016, Peer-reviewed

  
• Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma

  Osamu Kikuchi; Shinya Ohashi; Tomohisa Horibe; Masayuki Kohno; Yukie Nakai; Shin'Ichi Miyamoto; Tsutomu Chiba; Manabu Muto; Koji Kawakami

  Scientific Reports, 09 Mar. 2016, Peer-reviewed, Lead author

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• Recent Advances from Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma

  Shinya Ohashi; Shin'Ichi Miyamoto; Osamu Kikuchi; Tomoyuki Goto; Yusuke Amanuma; Manabu Muto

  Gastroenterology, 01 Dec. 2015

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• Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium

  Yusuke Amanuma; Shinya Ohashi; Yoshiro Itatani; Mihoko Tsurumaki; Shun Matsuda; Osamu Kikuchi; Yukie Nakai; Shin'Ichi Miyamoto; Tsunehiro Oyama; Toshihiro Kawamoto; Kelly A. Whelan; Hiroshi Nakagawa; Tsutomu Chiba; Tomonari Matsuda; Manabu Muto

  Scientific Reports, 16 Sep. 2015, Peer-reviewed

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• Serum MIR-21, MIR-29a, and MIR-125b are promising biomarkers for the early detection of colorectal neoplasia

  Atsushi Yamada; Takahiro Horimatsu; Yoshinaga Okugawa; Naoshi Nishida; Hajime Honjo; Hiroshi Ida; Tadayuki Kou; Toshihiro Kusaka; Yu Sasaki; Makato Yagi; Takuma Higurashi; Norio Yukawa; Yusuke Amanuma; Osamu Kikuchi; Manabu Muto; Yoshiyuki Ueno; Atsushi Nakajima; Tsutomu Chiba; C. Richard Boland; Ajay Goel

  Clinical Cancer Research, 15 Sep. 2015, Peer-reviewed

  
• Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression

  Osamu Kikuchi; Shinya Ohashi; Yukie Nakai; Shunsaku Nakagawa; Kazuaki Matsuoka; Takashi Kobunai; Teiji Takechi; Yusuke Amanuma; Masahiro Yoshioka; Tomomi Ida; Yoshihiro Yamamoto; Yasushi Okuno; Shin'ichi Miyamoto; Hiroshi Nakagawa; Kazuo Matsubara; Tsutomu Chiba; Manabu Muto

  American Journal of Cancer Research, 2015, Peer-reviewed, Lead author

  
• Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma

  Shinya Ohashi; Osamu Kikuchi; Mihoko Tsurumaki; Yukie Nakai; Hiroi Kasai; Takahiro Horimatsu; Shi N.Ichi Miyamoto; Akira Shimizu; Tsutomu Chiba; Manabu Muto

  PLoS ONE, 04 Aug. 2014, Peer-reviewed

  
• Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion.

  Yoshiyuki Yukawa 1 , Shinya Ohashi 2 , Yusuke Amanuma 1 , Yukie Nakai 3 , Mihoko Tsurumaki 3 , Osamu Kikuchi 1 , Shin'ichi Miyamoto 1 , Tsunehiro Oyama 4 , Toshihiro Kawamoto 4 , Tsutomu Chiba 1 , Tomonari Matsuda 5 , Manabu Muto 3

  American journal of cancer research, 26 May 2014, Peer-reviewed

  
• Narrow-band imaging for the head and neck region and the upper gastrointestinal tract

  Osamu Kikuchi; Yasumasa Ezoe; Shuko Morita; Takahiro Horimatsu; Manabu Muto

  Japanese Journal of Clinical Oncology, May 2013, Peer-reviewed, Lead author

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• Relationship Between Pancreatic Perfusion Parameters and Clinical Complications of Severe Acute Pancreatitis

  Tsubasa Watanabe; Yoshihisa Tsuji; Naoki Takahashi; Tsukasa Yoshida; Masashi Tamaoki; Osamu Kikuchi; Yuji Watanabe; Yuzo Kodama; Hiroyoshi Isoda; Hiroshi Yamamoto; Tsutomu Chiba

  Pancreas, Jan. 2013, Peer-reviewed

  
• Successful treatment of a patient with sepsis and liver abscess caused by Edwardsiella tarda

  Yoshiko Ohara; Osamu Kikuchi; Tomoyuki Goto; Tsukasa Yoshida; Hirokazu Mori; Kazuhiro Matsueda; Hiroshi Yamamoto

  Internal Medicine, 2012, Peer-reviewed

  
• Clinical significance of arterial blood resistance in viral acute hepatitis

  Hiroshi Ikeda; Yoshitaka Takuma; Osamu Kikuchi; Yoichi Morimoto; Hiroyuki Shimomura; Hiroshi Yamamoto; Junko Tomokuni

  Acta Hepatologica Japonica, 2011, Peer-reviewed

  
• Perfusion CT is superior to angiography in predicting pancreatic necrosis in patients with severe acute pancreatitis

  Yoshihisa Tsuji; Kyoko Hamaguchi; Yuji Watanabe; Akira Okumura; Hiroyoshi Isoda; Naoki Yamamoto; Osamu Kikuchi; Hiroyuki Yamamoto; Kazuhiro Matsueda; Kenji Ueno; Shinsuke Tada; Kaori Togashi; Hiroshi Yamamoto; Tsutomu Chiba

  Journal of Gastroenterology, Nov. 2010, Peer-reviewed

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Misc.

• EGFR inhibitors exert different effects on epithelial-like and mesenchymal-like esophageal squamous carcinoma cells

  Masahiro Yoshioka; Shinya Ohashi; Tomomi Ida; Yukie Nakai; Osamu Kikuchi; Yusuke Amanuma; Jun'ichi Matsubara; Atsushi Yamada; Shin'ichi Miyamoto; Manabu Muto

  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Nov. 2016

  
• 上皮様、間葉様の食道扁平上皮がんに対するEGFR阻害剤による分化誘導効果

  吉岡 正博; 大橋 真也; 菊池 理; 玉置 将司; 松原 淳一; 森 由希子; 宮本 心一; 武藤 学

  日本癌学会総会記事, Oct. 2016

  
• Establishment of a 5-fluorouracil-resistant esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase gene amplification

  Osamu Kikuchi; Kiichiro Baba; Shinya Ohashi; Manabu Muto

  CANCER RESEARCH, Feb. 2016

  
• Notch3過剰発現による食道扁平上皮分化誘導は腫瘍造成能及び5FU抵抗性を抑制する

  菊池 理; 大橋 真也; 天沼 裕介; 横山 顕礼; 宮本 心一; 松本 繁巳; 武藤 学

  日本食道学会学術集会プログラム・抄録集, Jul. 2015

  
• EGFR Inhibition Promotes Differentiation of Esophageal Squamous Cancer Cells Through Notch Signaling Pathway

  Masahiro Yoshioka; Shinya Ohashi; Osamu Kikuchi; Yusuke Amanuma; Tomomi Ida; Yukie Nakai; Hiroshi Nakagawa; Tsutomu Chiba; Manabu Muto

  GASTROENTEROLOGY, Apr. 2015

  
• Alcohol Induces ALDH2 As a Novel Cytoprotective Mechanism to Suppress Acetaldehyde-Derived DNA Adduct Formation in Esophageal Epithelial Cells

  Yusuke Amanuma; Shinya Ohashi; Osamu Kikuchi; Yukie Nakai; Shin-ichi Miyamoto; Koji Tanaka; Kelly A. Whelan; Hiroshi Nakagawa; Tsutomu Chiba; Tomonari Matsuda; Manabu Muto

  GASTROENTEROLOGY, Apr. 2015

  
• EGFR-lytic hybrid peptideの食道扁平上皮癌に対するin vitroでの有効性と安全性(Cytotoxicity and safety of EGFR-lytic hybrid peptide against esophageal squamous cell carcinoma in vitro)

  菊池 理; 大橋 真也; 堀部 智久; 河野 雅之; 武藤 学; 川上 浩司

  日本癌学会総会記事, Sep. 2014

  
• DPDの高発現を伴った5-FU耐性食道扁平上皮癌細胞株の樹立

  菊池 理; 大橋 真也; 中井 由起恵; 天沼 裕介; 江副 康正; 宮本 心一; 武藤 学

  日本食道学会学術集会プログラム・抄録集, Jul. 2014

  
• 食道上皮におけるALDH2発現誘導がアセトアルデヒドに起因する食道上皮傷害を制御する

  大橋 真也; 天沼 裕介; 鶴巻 美穂子; 中井 由起恵; 菊池 理; 宮本 心一; 千葉 勉; 松田 知成; 武藤 学

  日本食道学会学術集会プログラム・抄録集, Jul. 2014

  
• Pivotal Cytotoxic Activity of EGFR-Lytic Hybrid Peptide Against 5-Fluorouracil-Resistant Esophageal Squamous Cell Carcinoma In Vitro

  Osamu Kikuchi; Shinya Ohashi; Tomohisa Horibe; Masayuki Kohno; Manabu Muto; Koji Kawakami

  GASTROENTEROLOGY, May 2014

  
• 5-FU耐性食道扁平上皮癌細胞株の確立(Establishment of a novel 5-fluorouracil-resistant tumorigenic esophageal squamous cell carcinoma cell line)

  菊池 理; 大橋 真也; 栗山 大輔; 宮本 心一; 千葉 勉; 武藤 学

  日本癌学会総会記事, Oct. 2013

  
• 5FU耐性食道癌細胞株に対するタラポルフィンを用いた光線力学療法の効果(Photodynamic therapy with talaporfin sodium in fluorouracil-resistant esophageal squamous cell carcinoma cells)

  栗山 大輔; 大橋 真也; 中井 由紀恵; 鶴巻 美穂子; 菊池 理; 江副 康正; 宮本 心一; 千葉 勉; 武藤 学

  日本癌学会総会記事, Oct. 2013

  
• Aldehyde Dehydrogenase-2 Regulates Esophageal Epithelial Cell Senescence Checkpoint Functions Activated by an Alcohol Metabolite

  Yusuke Amanuma; Shinya Ohashi; Mihoko Tsurumaki; Osamu Kikuchi; Daisuke Kuriyama; Yukie Nakai; Takeshi Setoyama; Shinichi Miyamoto; Tsunehiro Oyama; Tsutomu Chiba; Manabu Muto

  GASTROENTEROLOGY, May 2013

  
• Photodynamic Therapy Induces Apoptosis via Reactive Oxygen Species in Fluorouracil-Resistant Esophageal Squamous Cell Carcinoma Cells

  Shinya Ohashi; Mihoko Tsurumaki; Osamu Kikuchi; Daisuke Kuriyama; Yusuke Amanuma; Yukie Nakai; Takeshi Setoyama; Shinichi Miyamoto; Tsutomu Chiba; Manabu Muto

  GASTROENTEROLOGY, May 2013

  
• Notch3-mediated squamous cell differentiation shows anti-tumor effect on esophageal squamous cell carcinoma as well as reduces its resistance to 5-Fluorouracil

  Osamu Kikuchi; Shinya Ohashi; Yukie Nakai; Yusuke Amanuma; Masahiro Yoshioka; Shin'ichi Miyamoto; Mitsuteru Natsuizaka; Hiroshi Nakagawa; Tsutomu Chiba; Manabu Muto

  CANCER RESEARCH, Aug. 2015

  

External funds: Kakenhi

• Development of ferroptosis induction therapy against KRAS altered gastric cancer

  Grant-in-Aid for Early-Career Scientists

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kyoto University

  Osamu Kikuchi

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  分子標的療法;KRAS;脂質過酸化物;MAPK;フェロトーシス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K16413/
• KRAS増幅胃癌におけるSprouty経路の機序解明と分子標的療法の開発

  Grant-in-Aid for Early-Career Scientists

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kyoto University

  菊池 理

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  胃癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K14617/
• Verifying the effectiveness and exploring the mechanism of cognitive training during chemotherapy for prevention of CRCI

  Grant-in-Aid for Scientific Research (B)

  Basic Section 58060:Clinical nursing-related

  Kyoto University

  宮下 美香

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  認知機能障害;化学療法;乳がん;認知トレーニング;バイオマーカー;がん;化学療法に関連した認知機能障害;予防;効果発現メカニズム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02730/

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2026

  特定認定再生医療等委員会 委員
• From 01 Apr. 2024, To 31 Mar. 2026

  臨床研究審査委員会 委員

Academic, Social Contribution

Committee Memberships

• From 2025, To Present

  医の倫理委員会 委員, 京都大学大学院医学研究科・医学部及び医学部附属病院
• From 2025, To Present

  臨床研究審査委員会 委員, 京都大学
• From 2025, To Present

  特定認定再生医療等委員会 委員, 京都大学