Basic Information

Professional Memberships

• From Apr. 2025, To Present

  The International Society for Neutron Capture Therapy
• From Apr. 2019, To Present

  JAPANESE SOCIETY FOR RADIATION ONCOLOGY
• From Apr. 2019, To Present

  THE JAPANESE SOCIETY OF NEUTRON CAPTURE THERAPY
• From Dec. 2018, To Present

  European Society of Therapeutic Radiation and Oncology
• From Apr. 2016, To Present

  JAPAN SOCIETY OF MEDICAL PHYSICS
• From Oct. 2009, To Present

  Australasian College of Physical Scientists and Engineers in Medicine

Academic Degree

• M.S.(University of Wollongong)
• 博士（工学）(京都大学)

Research History

• From Apr. 2023, To Present

  Osaka Medical and Pharmaceutical University, Kansai BNCT Medical Center, Lecturer | Medical Physicist
• From Apr. 2019, To Mar. 2023

  Osaka Medical and Pharmaceutical University, Kansai BNCT Medical Center, Assistant Professor
• From Sep. 2019, To Present

  Kyoto University, 粒子線腫瘍学研究センター, 特定助教（クロスアポイントメント）
• From Mar. 2015, To Mar. 2016

  Genesis Cancer Care, Radiation Oncology, Medical Physicist Specialist
• From Sep. 2009, To Mar. 2015

  Canberra Hospital, Medical Physics and Radiation Engineering, Medical Physicist

ID,URL

• J-Global ID

  201901004201845760

researchmap URL

• https://researchmap.jp/ko_naonori

Research

Research Interests

• Boron Neutron Capture Therapy
• Particle therapy
• Medical Physics
• Radiation Detection
• Radiation Physics

Research Areas

• Life sciences, Tumor diagnostics and therapeutics, Boron Neutron Capture Therapy

Papers

• ホウ素中性子捕捉療法の進歩と将来展望 転移性脊椎腫瘍に対する新規治療選択肢としてのホウ素中性子捕捉療法の橋渡し研究

  藤川 喜貴; 川端 信司; 辻野 晃平; 山田 浩徳; 柏木 秀基; 二村 元; 平松 亮; 高田 卓志; 鈴木 実; 呼 尚徳; 宮武 伸一; 高見 俊宏; 鰐渕 昌彦

  日本癌治療学会学術集会抄録集, Oct. 2024

  
• 脊髄神経膠腫に対するホウ素中性子捕捉療法の適応拡大に向けての橋渡し研究

  辻野 晃平; 香山 諒; 川端 信司; 藤川 喜貴; 柏木 秀基; 福尾 祐介; 平松 亮; 高田 卓志; 田中 浩基; 鈴木 実; 呼 尚徳; 宮武 伸一; 高見 俊宏; 鰐渕 昌彦

  日本癌治療学会学術集会抄録集, Oct. 2024

  
• 2方向の中性子照射と患者体位変換で実現した高悪性度髄膜腫へのホウ素中性子捕捉療法

  柏木 秀基; 川端 信司; 辻野 晃平; 竹内 孝治; 平松 亮; 野々口 直助; 古瀬 元雅; 呼 尚徳; 櫻井 良憲; 田中 浩基; 近藤 夏子; 鈴木 実; 小野 公二; 宮武 伸一; 鰐渕 昌彦

  日本癌治療学会学術集会抄録集, Oct. 2024

  
• Accelerator neutron sources for BNCT: Current status and some pointers for future development

  Stuart Green; Ben Phoenix; Satoshi Nakamura; Yuan Hao Liu; Diyun Shu; Naonori Hu; Shunsuke Suzuki; Hanna Koivunoro; Hiroaki Kumada; Hiroki Tanaka

  Applied Radiation and Isotopes, Mar. 2025, Peer-reviewed

  
• Evaluation of dose calculation method with a combination of Monte Carlo method and removal-diffusion equation in heterogeneous geometry for boron neutron capture therapy.

  Mai Nojiri; Takushi Takata; Akinori Sasaki; Yuki Tamari; Nishiki Matsubayashi; Naonori Hu; Yoshinori Sakurai; Minoru Suzuki; Hiroki Tanaka

  Biomedical physics & engineering express, 09 Jan. 2025

  
• Clinical evaluation of performance, stability, and longevity of an accelerator system designed for boron neutron capture therapy utilising a beryllium target.

  Naonori Hu; Ryo Kakino; Akinori Sasaki; Syuushi Yoshikawa; Kazuhiko Akita; Satoshi Takeno; Yuki Yoshino; Teruhito Aihara; Keiji Nihei; Mai Nojiri; Nishiki Matsubayashi; Takushi Takata; Hiroki Tanaka; Minoru Suzuki; Koji Ono

  Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Dec. 2024, Peer-reviewed, Lead author

  
• Characterization of acrylic phantom for use in quality assurance of BNCT beam output procedure.

  Nishiki Matsubayashi; Naonori Hu; Takushi Takata; Akinori Sasaki; Hiroaki Kumada; Satoshi Nakamura; Akihiko Masuda; Hiroki Tanaka

  Journal of radiation research, 19 Nov. 2024, Peer-reviewed

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• New technologies for beam spectrometry, quality assurance, real-time monitoring and microdosimetry in BNCT

  Hiroaki Kumada; Akihiko Masuda; Hiroki Tanaka; Masashi Takada; Naonori Hu

  Radiation Measurements, Sep. 2024, Peer-reviewed

  
• Implementation of optically simulated luminescent dosimeter for quality control of gamma ray dose of an accelerator-based neutron source.

  Naonori Hu; Taiki Nakamura; Ryusuke Kataura; Keita Suga; Tetsuya Mukawa; Kazuhiko Akita; Akinori Sasaki; Mai Nojiri; Nishiki Matsubayashi; Takushi Takata; Hiroki Tanaka; Keiji Nihei; Koji Ono

  Journal of applied clinical medical physics, 27 Aug. 2024, Peer-reviewed, Lead author, Corresponding author

  
• 悪性神経膠腫に対する葉酸受容体標的ホウ素キャリアを用いたホウ素中性子捕捉療法

  辻野 晃平; 川端 信司; 柏木 秀基; 香山 諒; 藤川 喜貴; 福尾 祐介; 平松 亮; 宮武 伸一; 呼 尚徳; 高田 卓志; 田中 浩基; 鈴木 実; 西村 開; 中村 浩之; 鰐渕 昌彦

  日本癌治療学会学術集会抄録集, Oct. 2023

  
• Boron neutron capture therapy delays the decline in neurological function in a mouse model of metastatic spinal tumors.

  Yoshiki Fujikawa; Shinji Kawabata; Kohei Tsujino; Hironori Yamada; Hideki Kashiwagi; Ryokichi Yagi; Ryo Hiramatsu; Naosuke Nonoguchi; Toshihiro Takami; Akinori Sasaki; Naonori Hu; Takushi Takata; Hiroki Tanaka; Minoru Suzuki; Masahiko Wanibuchi

  Cancer science, 11 Jun. 2024

  
• Preliminary outcomes of boron neutron capture therapy for head and neck cancers as a treatment covered by public health insurance system in Japan: Real‐world experiences over a 2‐year period

  Satoshi Takeno; Yuki Yoshino; Teruhito Aihara; Masaaki Higashino; Yasukazu Kanai; Naonori Hu; Ryo Kakino; Ryo Kawata; Keiji Nihei; Koji Ono

  Cancer Medicine, 03 Jun. 2024

  
• Nonclinical pharmacodynamics of boron neutron capture therapy using direct intratumoral administration of a folate receptor targeting novel boron carrier.

  Kohei Tsujino; Hideki Kashiwagi; Kai Nishimura; Yoshiki Fujikawa; Ryo Kayama; Yusuke Fukuo; Ryo Hiramatsu; Naosuke Nonoguchi; Takushi Takata; Hiroki Tanaka; Minoru Suzuki; Naonori Hu; Koji Ono; Masahiko Wanibuchi; Kei Nakai; Hiroyuki Nakamura; Shinji Kawabata

  Neuro-oncology advances, 2024

  
• Application of stoichiometric CT number calibration method for dose calculation of tissue heterogeneous volumes in boron neutron capture therapy

  Naonori Hu; Minoru Nakao; Shuichi Ozawa; Takushi Takata; Hiroki Tanaka; Keiji Nihei; Koji Ono; Minoru Suzuki

  Medical Physics, 26 Apr. 2024

  
• Translational research of boron neutron capture therapy for spinal cord gliomas using rat model.

  Ryo Kayama; Kohei Tsujino; Shinji Kawabata; Yoshiki Fujikawa; Hideki Kashiwagi; Yusuke Fukuo; Ryo Hiramatsu; Takashi Takata; Hiroki Tanaka; Minoru Suzuki; Naonori Hu; Shin-Ichi Miyatake; Toshihiro Takami; Masahiko Wanibuchi

  Scientific reports, 09 Apr. 2024

  
• 革新的治療はここにあり、頭頸部癌における新たな展開 頭頸部癌に対する加速器BNCTの初期治療効果

  粟飯原 輝人; 東野 正明; 武野 慧; 呼 尚徳; 二瓶 圭二; 河田 了; 小野 公二

  日本癌治療学会学術集会抄録集, Oct. 2023

  
• 悪性神経膠腫に対する葉酸受容体標的ホウ素キャリアを用いたホウ素中性子捕捉療法

  辻野 晃平; 川端 信司; 柏木 秀基; 香山 諒; 藤川 喜貴; 福尾 祐介; 平松 亮; 宮武 伸一; 呼 尚徳; 高田 卓志; 田中 浩基; 鈴木 実; 西村 開; 中村 浩之; 鰐渕 昌彦

  日本癌治療学会学術集会抄録集, Oct. 2023

  
• Neutron flux evaluation algorithm with a combination of Monte Carlo and removal‐diffusion calculation methods for boron neutron capture therapy

  Mai Nojiri; Takushi Takata; Naonori Hu; Yoshinori Sakurai; Minoru Suzuki; Hiroki Tanaka

  Medical Physics, 11 Jan. 2024

  
• Out‐of‐field dosimetry using a validated PHITS model and computational phantom in clinical BNCT

  Ryo Kakino; Naonori Hu; Hiroki Tanaka; Satoshi Takeno; Teruhito Aihara; Keiji Nihei; Koji Ono

  Medical Physics, 28 Dec. 2023, Peer-reviewed, Corresponding author

  
• Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model.

  Yoshiki Fujikawa; Yusuke Fukuo; Kai Nishimura; Kohei Tsujino; Hideki Kashiwagi; Ryo Hiramatsu; Naosuke Nonoguchi; Motomasa Furuse; Toshihiro Takami; Naonori Hu; Shin-Ichi Miyatake; Takushi Takata; Hiroki Tanaka; Tsubasa Watanabe; Minoru Suzuki; Shinji Kawabata; Hiroyuki Nakamura; Masahiko Wanibuchi

  Biology, 15 Sep. 2023

  
• Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy.

  Yoshihide Hattori; Tooru Andoh; Shinji Kawabata; Naonori Hu; Hiroyuki Michiue; Hiroyuki Nakamura; Takahiro Nomoto; Minoru Suzuki; Takushi Takata; Hiroki Tanaka; Tsubasa Watanabe; Koji Ono

  Journal of radiation research, 16 Sep. 2023

  
• 頭頸部癌の新たな治療戦略 ホウ素中性子捕捉療法

  粟飯原 輝人; 東野 正明; 呼 尚徳; 秋田 和彦; 二瓶 圭二; 河田 了; 小野 公二

  日本耳鼻咽喉科頭頸部外科学会会報, Jan. 2023

  
• Feasibility study of optical imaging of the boron‐dose distribution by a liquid scintillator in a clinical boron neutron capture therapy field

  Hideya Maeda; Akihiro Nohtomi; Naonori Hu; Ryo Kakino; Kazuhiko Akita; Koji Ono

  Medical Physics, 06 Sep. 2023

  
• Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study

  Naonori Hu; Minoru Suzuki; Shin-ichiro Masunaga; Genro Kashino; Yuko Kinashi; Yi-Wen Chen; Yong Liu; Koki Uehara; Toshinori Mitsumoto; Hiroki Tanaka; Koji Ono

  Journal of Radiation Research, 22 Aug. 2023, Peer-reviewed, Lead author

  
• Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies

  Andrea Monti Hughes; Naonori Hu

  Cancers, 14 Aug. 2023, Peer-reviewed

  
• Development of a prompt gamma-ray detector with an 8 × 8 array LaBr 3(Ce) scintillator and a multi-pixel photon counter for boron neutron capture therapy

  Keita Okazaki; Hiroki Tanaka; Takushi Takata; Shinji Kawabata; Naonori Hu; Nishiki Matsubayashi; Tetsuya Mukawa; Yoshinori Sakurai; Minoru Suzuki

  Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Aug. 2023, Peer-reviewed

  
• Imaging of gamma photons from activated gold wire using a high-energy gamma camera after irradiation of neutrons from boron neutron capture therapy (BNCT) system

  Seiichi Yamamoto; Naonori Hu; Jun Kataoka; Nanase Koshikawa; Yasukazu Kanai; Hiroki Tanaka; Koji Ono

  Journal of Instrumentation, 01 Apr. 2023, Peer-reviewed

  
• Development and evaluation of dose calculation algorithm with a combination of Monte Carlo and point-kernel methods for boron neutron capture therapy.

  Mai Nojiri; Takushi Takata; Naonori Hu; Yoshinori Sakurai; Minoru Suzuki; Hiroki Tanaka

  Biomedical physics & engineering express, 06 Apr. 2023

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• Development of optimization method for uniform dose distribution on superficial tumor in an accelerator-based boron neutron capture therapy system

  Akinori Sasaki; Naonori Hu; Nishiki Matsubayashi; Takushi Takata; Yoshinori Sakurai; Minoru Suzuki; Hiroki Tanaka

  Journal of Radiation Research, 26 Apr. 2023

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• 頭頸部癌の新たな治療戦略 ホウ素中性子捕捉療法

  粟飯原 輝人; 東野 正明; 呼 尚徳; 秋田 和彦; 二瓶 圭二; 河田 了; 小野 公二

  日本耳鼻咽喉科頭頸部外科学会会報, Jan. 2023

  
• Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model.

  Hideki Kashiwagi; Yoshihide Hattori; Shinji Kawabata; Ryo Kayama; Kohei Yoshimura; Yusuke Fukuo; Takuya Kanemitsu; Hiroyuki Shiba; Ryo Hiramatsu; Toshihiro Takami; Takushi Takata; Hiroki Tanaka; Tsubasa Watanabe; Minoru Suzuki; Naonori Hu; Shin-Ichi Miyatake; Mitsunori Kirihata; Masahiko Wanibuchi

  Cancers, 06 Feb. 2023, Peer-reviewed

  
• Improved Boron Neutron Capture Therapy Using Integrin αvβ3-Targeted Long-Retention-Type Boron Carrier in a F98 Rat Glioma Model

  Kohei Tsujino; Hideki Kashiwagi; Kai Nishimura; Ryo Kayama; Kohei Yoshimura; Yusuke Fukuo; Hiroyuki Shiba; Ryo Hiramatsu; Naosuke Nonoguchi; Motomasa Furuse; Toshihiro Takami; Shin-Ichi Miyatake; Naonori Hu; Takushi Takata; Hiroki Tanaka; Minoru Suzuki; Shinji Kawabata; Hiroyuki Nakamura; Masahiko Wanibuchi

  Biology, 27 Feb. 2023

  
• Accelerator based epithermal neutron source for clinical boron neutron capture therapy

  Naonori Hu; Hiroki Tanaka; Kazuhiko Akita; Ryo Kakino; Teruhito Aihara; Keiji Nihei; Koji Ono

  Journal of Neutron Research, 18 Jan. 2023, Peer-reviewed, Invited, Lead author

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• Characteristics of optically stimulated luminescent dosimeter of beryllium oxide in BNCT irradiation field

  Nishiki Matsubayashi; Naonori Hu; Takushi Takata; Akinori Sasaki; Tetsuya Mukawa; Keita Suga; Yoshinori Sakurai; Hiroki Tanaka

  Radiation Measurements, Feb. 2023, Peer-reviewed

  
• Air ionization chamber combined with LiCaAlF6 scintillator for γ-ray dose evaluation in boron neutron capture therapy

  Nishiki Matsubayashi; Naonori Hu; Takushi Takata; Akinori Sasaki; Mai Nojiri; Tetsuya Mukawa; Yoshinori Sakurai; Hiroki Tanaka

  Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Feb. 2023, Peer-reviewed

  
• Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT.

  Kayako Isohashi; Yasukazu Kanai; Teruhito Aihara; Naonori Hu; Kentaro Fukushima; Ichiro Baba; Fumitoshi Hirokawa; Ryo Kakino; Tsuyoshi Komori; Keiji Nihei; Jun Hatazawa; Koji Ono

  European journal of hybrid imaging, 05 Dec. 2022, Peer-reviewed

  
• Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT

  Akinori Sasaki; Naonori Hu; Takushi Takata; Nishiki Matsubayashi; Yoshinori Sakurai; Minoru Suzuki; Hiroki Tanaka

  Journal of Radiation Research, 22 Sep. 2022

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• Successful salvage surgery of the residual tumor after boron neutron capture therapy (BNCT): A case report.

  Masaaki Higashino; Teruhito Aihara; Akiko Ozaki; Naonori Hu; Kayako Isohashi; Koji Ono; Keiji Nihei; Yoshitaka Kurisu; Ryo Kawata

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 18 Aug. 2022

  
• Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region

  Naonori Hu; Hiroki Tanaka; Ryo Kakino; Syuushi Yoshikawa; Mamoru Miyao; Kazuhiko Akita; Teruhito Aihara; Keiji Nihei; Koji Ono

  Scientific Reports, 12 Aug. 2022, Peer-reviewed, Lead author

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• Design of a filtration system to improve the dose distribution of an accelerator‐based neutron capture therapy system

  Naonori Hu; Hiroki Tanaka; Koji Ono

  Medical Physics, Oct. 2022, Peer-reviewed, Lead author

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• Comprehensive evaluation of dosimetric impact against position errors in accelerator‐based BNCT under different treatment parameter settings

  Ryo Kakino; Naonori Hu; Kayako Isohashi; Teruhito Aihara; Keiji Nihei; Koji Ono

  Medical Physics, 27 Jun. 2022

  
• Development of an irradiation method for superficial tumours using a hydrogel bolus in an accelerator-based BNCT

  Akinori Sasaki; Hiroki Tanaka; Takushi Takata; Yuki Tamari; Tsubasa Watanabe; Naonori Hu; Shinji Kawabata; Yoshihiro Kudo; Toshinori Mitsumoto; Yoshinori Sakurai; Minoru Suzuki

  Biomedical Physics & Engineering Express, 25 Nov. 2021, Peer-reviewed

  
• Development of a real-time neutron detector for measurement at whole body position in BNCT

  H. Tanaka; T. Takata; M. Sato; N. Matsubayashi; K. Okazaki; N. Hu; S. Kawabata; Y. Sakurai; S. Masunaga; M. Suzuki

  2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019, Oct. 2019

  
• Optical imaging of lithium-containing zinc sulfate plate in water during irradiation of neutrons from boron neutron capture therapy (BNCT) system.

  Seiichi Yamamoto; Takuya Yabe; Naonori Hu; Yasukazu Kanai; Hiroki Tanaka; Koji Ono

  Medical physics, 27 Dec. 2021, Peer-reviewed

  
• Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation

  Kohei Yoshimura; Shinji Kawabata; Hideki Kashiwagi; Yusuke Fukuo; Koji Takeuchi; Gen Futamura; Ryo Hiramatsu; Takushi Takata; Hiroki Tanaka; Tsubasa Watanabe; Minoru Suzuki; Naonori Hu; Shin-Ichi Miyatake; Masahiko Wanibuchi

  Cells, 02 Dec. 2021, Peer-reviewed

  
• Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

  Naonori Hu; Hiroki Tanaka; Ryo Kakino; Syuushi Yoshikawa; Mamoru Miyao; Kazuhiko Akita; Kayako Isohashi; Teruhito Aihara; Keiji Nihei; Koji Ono

  Radiation Oncology, Dec. 2021, Peer-reviewed, Lead author

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• Development of an irradiation method for superficial tumours using a hydrogel bolus in an accelerator-based BNCT

  Akinori Sasaki; Hiroki Tanaka; Takushi Takata; Yuki Tamari; Tsubasa Watanabe; Naonori Hu; Shinji Kawabata; Yoshihiro Kudo; Toshinori Mitsumoto; Yoshinori Sakurai; Minoru Suzuki

  Biomedical Physics & Engineering Express, 25 Nov. 2021, Peer-reviewed

  
• Photoneutron-induced damage reduction for cardiac implantable electronic devices using neutron-shielding sheets in high-energy X-ray radiotherapy: A phantom study.

  Ryo Kakino; Mitsuhiro Nakamura; Naonori Hu; Hiraku Iramina; Hiroki Tanaka; Yoshinori Sakurai; Takashi Mizowaki

  Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 06 Aug. 2021, Peer-reviewed

  
• First measured optical image of Cerenkov-light in water during irradiation of neutron beam from boron neutron capture therapy (BNCT) system

  Takuya Yabe; Seiichi Yamamoto; Naonori Hu; Yasukazu Kanai; Hiroki Tanaka; Koji Ono

  RADIATION MEASUREMENTS, Aug. 2021, Peer-reviewed

  
• Improving the spatial resolution of a pixelated LaBr3(Ce) scintillator coupled with a multi-pixel photon counter array for boron neutron capture therapy

  Keita Okazaki; Hiroki Tanaka; Takushi Takata; Naonori Hu; Tetsuya Mukawa; Yoshinori Sakurai; Minoru Suzuki

  Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Mar. 2021, Peer-reviewed

  
• Development of a dose distribution shifter to fit inside the collimator of a Boron Neutron Capture Therapy irradiation system to treat superficial tumours

  N. Hu; H. Tanaka; S. Yoshikawa; M. Miyao; K. Akita; T. Aihara; K. Ono

  Physica Medica, Feb. 2021, Peer-reviewed, Lead author

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• Development of the world's first boron neutron capture therapy (BNCT) treatment system

  Hiroki Tanaka; Toshinori Mitsumoto; Naonori Hu

  Journal of the Atomic Energy Society of Japan, Jan. 2021, Invited

  
• The Therapeutic Effects of Dodecaborate Containing Boronophenylalanine for Boron Neutron Capture Therapy in a Rat Brain Tumor Model

  Yusuke Fukuo; Yoshihide Hattori; Shinji Kawabata; Hideki Kashiwagi; Takuya Kanemitsu; Koji Takeuchi; Gen Futamura; Ryo Hiramatsu; Tsubasa Watanabe; Naonori Hu; Takushi Takata; Hiroki Tanaka; Minoru Suzuki; Shin-Ichi Miyatake; Mitsunori Kirihata; Masahiko Wanibuchi

  Biology, 01 Dec. 2020, Peer-reviewed

  
• Boron neutron capture therapy for malignant brain tumors

  Shin-Ichi Miyatake; Masahiko Wanibuchi; Naonori Hu; Koji Ono

  Journal of Neuro-Oncology, Aug. 2020, Peer-reviewed

  
• Evaluation of PHITS for microdosimetry in BNCT to support radiobiological research

  N. Hu; H. Tanaka; T. Takata; S. Endo; S. Masunaga; M. Suzuki; Y. Sakurai

  Applied Radiation and Isotopes, Jul. 2020, Peer-reviewed, Lead author

  
• Microdosimetric quantities of an accelerator-based neutron source used for boron neutron capture therapy measured using a gas-filled proportional counter

  Naonori Hu; Hiroki Tanaka; Takushi Takata; Keita Okazaki; Ryohei Uchida; Yoshinori Sakurai

  Journal of Radiation Research, 23 Mar. 2020, Peer-reviewed, Lead author

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• Feasibility study on the use of 3D silicon microdosimeter detectors for microdosimetric analysis in boron neutron capture therapy

  N. Hu; R. Uchida; L.T. Tran; A. Rosenfeld; Y. Sakurai

  Applied Radiation and Isotopes, Oct. 2018, Peer-reviewed, Lead author

  
• Neutron beam quality measurement of the Kyoto University Reseasrch Reactor using microdosimetric technique

  Naonori KO

  Proceedings of the 115th Scientific Meeting of JSMP, 2018

  
• Investigation of the effect of boron distribution inside a silicon microdosimeter

  Naonori KO

  Proceedings of the World Congress on Medical Physics & Biomedical Engineering, 2018

  
• Neutron beam quality measurement of accelerator-based neutron source using microdosimetric technique

  Naonori KO

  Proceedings of the 18th International Congress on Neutron Capture Therapy, 2018

  
• Measurement of microdosimetric quantities of a neutron source using a tissue equivalent proportional counter

  Naonori KO

  Proceedings of the IEEE/NSS/MIC, 2018

  
• 3D Silicon Microdosimetry for Boron Neutron Capture Therapy: A Simulation Study

  Naonori KO

  Proceedings of the 17th Asia-Oceania Congress of Medical Physics, 2017

  
• Measurement of radiotherapy CBCT dose in a phantom using different methods

  Naonori Hu; Donald McLean

  Australasian Physical & Engineering Sciences in Medicine, Dec. 2014, Peer-reviewed, Lead author

  
• Silicon-on-Insulator Microdosimetry for Space Application

  Naonori KO

  University of Wollongong, Jul. 2013, Peer-reviewed

  

Misc.

• 乳房外パジェット病へのBNCT適応拡大の可能性

  礒橋佳也子; 礒橋佳也子; 金井泰和; 柿野諒; 呼尚徳; 小森剛; 二瓶圭二; 小野公二

  核医学(Web), 2022

  
• Combination of Convection-enhanced delivery (CED) and the novel boron carrier for boron neutron capture therapy

  辻野晃平; 川端信司; 柏木秀基; 香山諒; 藤川喜貴; 福尾祐介; 平松亮; 高田卓志; 田中浩基; 鈴木実; 宮武伸一; 呼尚徳; 中井啓; 西村開; 中村浩之; 鰐渕昌彦

  日本脳腫瘍学会学術集会プログラム・抄録集, 2023

  
• Translational research of boron neutron capture therapy for spinal cord and spine tumor in animal models

  藤川喜貴; 川端信司; 香山諒; 辻野晃平; 柏木秀基; 福尾祐介; 平松亮; 高田卓志; 田中浩基; 鈴木実; 呼尚徳; 宮武伸一; 高見俊宏; 鰐渕昌彦

  日本脳腫瘍学会学術集会プログラム・抄録集, 2023

  
• Potential and prospects of boron neutron capture therapy using a combination of multiple boron agents

  川端信司; 辻野晃平; 柏木秀基; 吉村亘平; 平松亮; 野々口直助; 古瀬元雅; 高見俊宏; 呼尚徳; 小野公二; 宮武伸一; 鰐渕昌彦

  日本脳腫瘍学会学術集会プログラム・抄録集, 2022

  
• Basic research of boron neutron capture therapy using a novel boron compound targeted to integrin

  辻野晃平; 川端信司; 柏木秀基; 吉村亘平; 香山諒; 福尾祐介; 金光拓也; 平松亮; 呼尚徳; 宮武伸一; 西村開; 高田卓志; 田中浩基; 鈴木実; 中村浩之; 鰐渕昌彦

  日本脳腫瘍学会学術集会プログラム・抄録集, 2022

  
• Gamma dose evaluation method with BeO OSLD in BNCT

  松林錦; 高田卓志; 呼尚徳; 笹木彬礼; 武川哲也; 菅啓大; 櫻井良憲; 田中浩基

  KURNS-EKR (Web), 2023

  
• BNCT照射場におけるBeO光刺激ルミネッセンス線量計の利用

  松林錦; 高田卓志; 呼尚徳; 笹木彬礼; 武川哲也; 菅啓大; 櫻井良憲; 田中浩基

  放射線(Web), 2023

  
• ラットを用いた脊髄神経膠腫に対するホウ素中性子捕捉療法の橋渡し研究

  藤川喜貴; 川端信司; 香山諒; 辻野晃平; 柏木秀基; 福尾祐介; 平松亮; 高田卓志; 田中浩基; 鈴木実; 呼尚徳; 宮武伸一; 高見俊宏; 鰐渕昌彦

  日本分子脳神経外科学会プログラム・抄録集, 2023

  
• アルブミンを基盤としたホウ素中性子捕捉療法用DDS薬剤のラット悪性神経膠腫モデルを用いた基礎研究

  辻野晃平; 川端信司; 柏木秀基; 香山諒; 藤川喜貴; 福尾祐介; 竹内孝治; 平松亮; 高田卓志; 田中浩基; 鈴木実; 呼尚徳; 宮武伸一; 西村開; 中村浩之; 鰐渕昌彦

  日本分子脳神経外科学会プログラム・抄録集, 2023

  
• Interim results of investigator-lead clinical trial of accelerator-based BNCT for treatment-refractory, recurrent high-grade meningiomas

  宮武伸一; 宮武伸一; 鰐渕昌彦; 鰐渕昌彦; 川端信司; 古瀬元雅; 小野公二; 二瓶圭二; 秋田和彦; 呼尚徳; 鈴木実; 櫻井良憲; 田中浩基

  日本脳腫瘍学会学術集会プログラム・抄録集, 2022

  
• 乳房外パジェット病へのBNCT適応拡大の可能性

  礒橋 佳也子; 金井 泰和; 柿野 諒; 呼 尚徳; 小森 剛; 二瓶 圭二; 小野 公二

  核医学, 2022

  
• 頭頸部癌に対するホウ素中性子捕捉療法

  粟飯原輝人; 粟飯原輝人; 東野正明; 呼尚徳; 礒橋佳也子; 秋田和彦; 二瓶圭二; 二瓶圭二; 河田了; 小野公二

  日本耳鼻咽喉科頭頚部外科学会会報, 2022

  
• 高悪性度髄膜腫に対するホウ素中性子捕捉療法(BNCT)の成績

  鰐渕昌彦; 宮武伸一; 黒岩敏彦; 川端信司; 呼尚徳; 二瓶圭二; 小野公二

  日本脳腫瘍の外科学会プログラム・抄録集, 2020

  
• Development of Fast Neutron Detection Method Discriminating Gamma-ray Events with Single Ionization Chamber in BNCT Field

  MATSUBAYASHI Nishiki; SASAKI Akinori; NOJIRI Mai; KO Naonori; TAKATA Takushi; SAKURAI Yoshinori; TANAKA Hiroki

  日本放射線技術学会総会学術大会予稿集, 2022

  
• Microdosimetry for Formation of Brain Radiation Necrosis in Particle Irradiation Field using LET Counter

  櫻井良憲; 近藤夏子; 高田卓志; 呼尚徳; 久米恭; 前田宗利

  若狭湾エネルギー研究センター研究年報, 2019

  
• Experimental evaluation of the therapeutic potential of boron neutron capture therapy in primary central nervous system lymphoma

  吉村亘平; 柏木秀基; 川端信司; 福尾祐介; 竹内孝治; 平松亮; 呼尚徳; 田中浩基; 鈴木実; 宮武伸一; 鰐渕昌彦

  日本脳腫瘍学会プログラム・抄録集, 2021

  
• ホウ素中性子捕捉療法のための新しいボーラス材の開発

  笹木彬礼; 高田卓志; 濱田敏正; 呼尚徳; 鈴木実; 櫻井良憲; 密本俊典; 田中浩基

  放射線(Web), 2020

  
• A PHASE II CLINICAL TRIAL USING ACCELERATOR-BASED BNCT SYSTEM FOR REFRACTORY RECURRENT HIGH-GRADE MENINGIOMA

  Shin-Ichi Miyatake; Masahiko Wanibuchi; Shinji Kawabata; Naonori Ko; Koji Ono

  NEURO-ONCOLOGY, Nov. 2020

  
• Results of reactor-based BNCT for 44 cases of recurrent and refractory high-grade meningiomas and road to accelerator based BNCT

  宮武伸一; 宮武伸一; 川端信司; 鰐渕昌彦; 鰐渕昌彦; 高井聡; 竹内孝治; 小野公二; 呼尚徳; 櫻井良憲; 田中浩基; 鈴木実

  日本脳腫瘍学会プログラム・抄録集, 2020

  

Presentations

• Beam commissioning and quality assurance for BNCT

  Naonori Hu

  1st Siriraj International Conference on Particle Therapy, 07 Mar. 2025, Invited

  
• Beam design and physical dosimetry of accelerator-based BNCT

  Naonori Hu

  1st Siriraj International Conference on Particle Therapy, 06 Mar. 2025, Invited

  
• BNCT treatment planning and plan evaluation

  Naonori Hu

  1st Siriraj International Conference on Particle Therapy Workshop, 05 Mar. 2025, Invited

  
• 臨床機関のニーズに適合した加速器型BNCTシステムの品質保証方法のための検出器システムの実装

  呼尚徳; 中村泰基; 片浦隆介; 菅啓太; 武川哲也; 秋田和彦; 柿野諒; 笹木彬礼; 野尻摩依; 松林錦; 髙田卓志; 田中浩基; 二瓶圭二; 小野公二

  放射線の線量計測と医学応用のための研究会, 01 Mar. 2025

  
• Current status and recent technologies in quality assurance of an accelerator based boron neutron capture therapy system

  Naonori Hu; Ryo Kakino; Akinori Sasaki; Nishiki Matsubayashi; Takushi Takata; Hiroki Tanaka; Keiji Nihei; Koji Ono

  Mini Micro Nano Dosimetry - Innovation Technologies in Radiation Oncology, 19 Feb. 2025, Invited

  
• BNCT臨床の現状と、関連する医学物理学研究について

  呼尚徳

  第33回放射線利用総合シンポジウム, 24 Jan. 2025, Invited

  
• Transition of fundamental BNCT medical physics research to the clinic

  Naonori Hu

  The 20th Congress on Neutron Capture Therapy, 27 Jul. 2024, Invited

  
• Investigation of the clinical application of optically simulated luminescence dosimeter for quality control of gamma ray dosimetry of an accelerator-based neutron source

  呼尚徳; 中村泰基; 片浦隆介; 菅啓大; 武川哲也; 秋田和彦; 笹木彬礼; 野尻摩依; 松林錦; 髙田卓志; 田中浩基; 鈴木実; 二瓶圭二; 小野公二

  The 20th Congress on Neutron Capture Therapy, 26 Jul. 2024

  
• Performance, stability, and long-term use of NeuCure® BNCT accelerator system from a clinical perspective

  呼尚徳; 柿野諒; 笹木彬礼; 吉川秀司; 秋田和彦; 武野慧; 吉野祐樹; 粟飯原輝人; 二瓶圭二; 野尻摩依; 松林錦; 髙田卓志; 田中浩基; 鈴木実; 小野公二

  The 20th Congress on Neutron Capture Therapy, 26 Jul. 2024

  
• BNCTの線量評価 原理・測定・計算

  呼尚徳

  第12回BNCT講習会, 25 Jul. 2024, Invited

  
• Implementation of OSLD for quality control of gamma ray dose measurement of an accelerator-based neutron source

  Naonori Hu; Taiki Nakamura; Ryusuke Kataura; Keita Suga; Tetsuya Mukawa; Kazuhiko Akita; Akinori Sasaki; Mai Nojiri; Nishiki Matsubayashi; Takushi Takata; Hiroki Tanaka; Keiji Nihei; Koji Ono

  20th International Congress on Neutron Capture Therapy, 27 Jun. 2024

  
• Introduction to the world’s first commercially available treatment planning system for boron neutron capture therapy

  Naonori Hu

  Raysearch Particle Therapy User Meeting, 11 Jun. 2024, Invited

  
• What is necessary for the next generation of accelerator-based BNCT irradiation system to advance toward standard treatment: based on 3 years of clinical experience.

  Naonori Hu; Ryo Kakino; Akinori Sasaki; Satoshi Takeno; Yuki Yoshino; Teruhito Aihara; Keiji Nihei; Hiroki Tanaka; Minoru Suzuki; Koji Ono

  5th Japan-Taiwan Neutron Capture Therapy Academic Conference of Elite, 20 Apr. 2024, Invited

  
• Personal experience during the clinical commissioning of a BNCT facility and future prospects

  Naonori Hu

  ISNCT webinar, 01 Dec. 2023, Invited

  
• Comparison of neutron beam quality between various neutron sources designed for boron neutron capture therapy and the clinical impact

  Naonori Hu; Ryo Kakino; Hiroki Tanaka; Satoshi Takeno; Teruhito Aihara; Keiji Nihei; Koji Ono

  126th Japanese Society of Medical Physics, 17 Sep. 2023

  
• Advancement in the neutron beam collimation for an accelerator based neutron source for application in clinical boron neutron capture therapy

  Naonori Hu; Hiroki Tanaka; Ryo Kakino; Kazuhiko Akita; Syuushi Yoshikawa; Mamoru Miyao; Satoshi Takeno; Teruhito Aihara; Keiji Nihei; Koji Ono

  65th Annual Meeting American Association of Physicists in Medicine, 23 Jul. 2023

  
• Implementation of a beam shaping system designed for an accelerator-based BNCT system optimised for head and neck cancer

  Naonori Hu; Hiroki Tanaka; Ryo Kakino; Syuushi Yoshikawa; Mamoru Miyao; Kazuhiko Akita; Satoshi Takeno; Teruhito Aihara; Keiji Nihei; Koji Ono

  61st Annual Particle Therapy Co-operative Group, 07 Jun. 2023

  
• Advancement in the Beam Collimation of an Accelerator-Based Neutron Source

  Naonori Hu

  Neutron Capture Therapy Academic Conference of Elite, 18 Mar. 2023, Invited

  
• Compact accelerator based epithermal neutron source and its application for cancer therapy

  Naonori Hu

  23rd International Conference on Cyclotrons and their Applications, 07 Dec. 2022, Invited

  
• Clinical application of a conical neutron beam collimation system for accelerator based BNCT

  35th Annual meeting of the Japanese Society for Radiation Oncology, 11 Nov. 2022

  
• Introduction to the world’s first university hospital based clinical BNCT center

  Naonori Hu

  2nd virtual educational webinar on BNCT organised by Cosylab, 10 Nov. 2022, Invited

  
• Development of a conical neutron beam collimation system for application in accelerator based neutron source for head and neck BNCT

  Naonori Hu

  第124回日本医学物理学会学術大会, 16 Sep. 2022

  
• BNCTの線量評価：X線との違い（領域講演）

  23rd Radiation Oncology Summer Seminar, 06 Aug. 2022, Invited

  
• Commissioning of the world's first clinical BNCT treatment planning system and validation against an independent Monte Carlo dose calculation system

  Naonori Hu

  IUPESM World Congress on Medical Physics and Biomedical Engineering, 12 Jun. 2022

  
• Commissioning of a treatment planning system used for clinical BNCT and validation against an independent Monte Carlo dose calculation system

  Naonori Hu

  第123回日本医学物理学会学術大会, 16 Apr. 2022

  
• Design, verification, and application of a filtration system to improve the dose distribution of an accelerator-based neutron capture therapy system

  Naonori Hu

  第123回日本医学物理学会学術大会, 16 Apr. 2022

  
• マイクロドジメトリを利用したBNCT中性子照射場の線質評価

  呼尚徳

  第56回複合原子力科学研究所学術講演会, 10 Feb. 2022, Invited

  
• Investigation, Design and Application of an Interchangeable Filter System to Improve the Dose Distribution of an Accelerator-Based Boron Neutron Capture Therapy System

  Naonori Hu

  3rd Taiwan-Japan Neutron Capture Therapy Academic Conference of Elite, 11 Dec. 2021, Invited

  
• Design of a filtration system to improve the dose distribution for an accelerator-based BNCT

  Naonori Hu

  19th International Congress on Neutron Capture Therapy, 08 Sep. 2021

  
• Development of a dose distribution shifter to fit inside the collimator of a BNCT irradiation system to treat superficial tumours

  Naonori Hu

  121st Scientific Meeting of JSMP, 18 Apr. 2021

  
• Investigation of an interchangeable moderator system for superficial BNCT treatment

  Naonori Hu

  2nd Taiwan-Japan Neutron Capture Therapy Academic Conference of Elite, 31 Oct. 2020, Invited

  
• Development of a collimator built-in type dose distribution shifter for boron neutron capture therapy to superficial tumour

  Naonori Hu

  IAEA technical meeting on advances in boron neutron capture therapy, 27 Jul. 2020

  
• Evaluation of a treatment planning system used for BNCT at the Kansai BNCT medical center

  Naonori KO

  10th Young Researchers BNCT meeting, 27 Sep. 2019

  
• Determination of RBE for BNCT fields using PHITS Monte Carlo simulation

  Naonori KO

  第118回日本医学物理学会学術大会, 13 Sep. 2019

  
• 関西BNCT共同医療センターにおけるBNCT治療計画システムの評価

  呼 尚徳

  第16回日本中性子捕捉療法学会学術大会, 08 Sep. 2019

  
• Neutron beam quality measurement of accelerator-based neutron source using microdosimetric technique

  Naonori KO

  18th International Congress on Neutron Capture Therapy, 28 Oct. 2018

  
• Investigation of the effect of boron distribution inside a silicon microdosimeter

  Naonori KO

  World Congress on Medical Physics & Biomedical Engineering, 03 Jun. 2018

  
• マイクロドジメトリによる京大炉BNCT照射場の線質評価

  呼 尚徳

  平成30年度京都大学複合原子力科学研究所専門研究会, 24 May 2018

  
• Investigation of SOI microdosimeter in Boron Neutron Capture Therapy

  Naonori KO

  9th Young Researchers' BNCT meeting, 13 Nov. 2017

  
• 3D Silicon Microdosimetry for Boron Neutron Capture Therapy: A Simulation Study

  Naonori KO

  17th Asia-Oceania Congress of Medical Physics, 04 Nov. 2017

  
• BNCT照射場におけるシリコンマイクロドジメター半導体検出器による線質評価

  呼 尚徳

  平成29年度京都大学原子力実験所専門研究会, 01 Sep. 2017

  
• BNCT照射場におけるシリコンマイクロドジメター半導体検出器による線質評価に関する可能性検証

  呼 尚徳

  第14回日本中性子捕捉療法学会学術大会, 01 Sep. 2017

  
• To establish a quality control and quality assurance program for patient dosimetry in boron neutron capture therapy

  Naonori KO

  G20 Think 20 Global Solutions Summit, 29 May 2017

  
• Accelerator based epithermal neutron source for clinical boron neutron capture therapy

  Naonori Hu

  9th international symposium for union for compact accelerator-driven neutron sources, 29 Mar. 2022, Invited

  

Books and Other Publications

• Training Workshop on Advances in Boron Neutron Capture Therapy

  Naonori Hu, Joint work, Chapter 4: BNCT Treatment Planning

  Okayama University IAEA Collaborating Centre, Oct. 2023

  Find Kyoto University's collection of books :

  
• Advances in Accelerators and Medical Physics

  Naonori Hu, Contributor, Therapy method, irradiation method, and immobilization and positioning of patients (brain)

  Elsevier, May 2023, Refereed

  Find Kyoto University's collection of books :

  
• Characteristics and Applications of Boron

  Shinji Kawabata; Naonori Hu; Ryo Hiramatsu; Kohei Tsujino; Naokado Ikeda; Naosuke Nonoguchi; Motomasa Furuse; Masahiko Wanibuchi, Joint work, Boron Compounds for Neutron Capture Therapy in the Treatment of Brain Tumors

  IntechOpen, 02 Aug. 2022

  Find Kyoto University's collection of books :

  

Awards

• 17 Jun. 2022

  YoungMedicalPhysicistBestPresentationAward of IOMP

Media Coverage

• Designing, Operating and Financing a BNCT Center

  Cosylab, Feb. 2023, Internet

  
• 次世代ひらく放射線がん治療施設、スタッフの連係カギに

  日本経済新聞, 現場探究, Jul. 2021, Paper

  

Academic, Social Contribution

Committee Memberships

• From Jun. 2024, To Present

  計測委員会, 日本医学物理学会
• From Apr. 2023, To Present

  Medical Physics examination committee, Japanese Board for Medical Physicist Qualification
• From Apr. 2022, To Present

  QA/QC committee (BNCT working group), Japanese Society of Medical Physics
• From Jul. 2021, To Present

  Treatment guideline committee, Japanese Society of Neutron Capture Therapy
• From Sep. 2020, To Present

  Communication Task Force, International Society for Neutron Capture Therapy
• From Apr. 2020, To Present

  International relations, Japan Society of Medical Physics

Academic Contribution

• The 6th Taiwan-Japan Neutron Capture Therapy Academic Conference of Elite

  Panel moderator

  Tamkang University, From 20 Apr. 2025, To 20 Apr. 2025

  
• Parallel session - Medical Physics

  Panel moderator

  International Congress on Neutron Capture Therapy, From 27 Jun. 2024, To 27 Jun. 2024

  
• Beam Delivery and Nozzle Design 2

  Panel moderator

  61st Annual Conference of the Particle Therapy Co-Operative Group, From 14 Jun. 2023, To 14 Jun. 2023

  
• Integration of Research for Patients From Medical Physics

  Panel moderator

  Japanese Society of Neutron Capture Therapy, From 26 Jul. 2024, To 27 Jul. 2024

  
• Particle Therapy: Imaging & Dosimetric Evaluation

  Panel moderator

  Japan Society of Medical Physics, From 11 Apr. 2024, To 14 Apr. 2024

  
• IAEA BNCT training workshop

  Planning, management, etc., Panel moderator, session chair, etc.

  IAEA・Okayama University・Osaka Medical and Pharmaceutical University, From 03 Jul. 2023, To 07 Jul. 2023

  
• YBNCT2022

  Planning, management, etc., Panel moderator, Planning/Implementing academic research

  International Society for Neutron Capture Therapy, From 14 Nov. 2022, To 18 Nov. 2022

  
• YBNCT9 organising committee

  Planning, management, etc., Planning/Implementing academic research

  Kyoto University Institute for Integrated Radiation and Nuclear Science, From 01 Apr. 2017, To 15 Nov. 2017

  

Social Contribution

• 

  International Day of Medical Physics - Seminar

  Guest, Official expert, Planner, Logistic support

  Japanese Society of Medical Physics, From 07 Nov. 2024, To 07 Nov. 2024

  
• International Day of Medical Physics - Seminar

  Host, Interviewer

  関西医科大学附属病院, From 07 Nov. 2023, To 07 Nov. 2023