Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医科学専攻・医学専攻, ヒト胚発生学・分子器官形成学分野, 教授

Academic Degree

• (Ruhr University Bochum (RUB))
• (Ruhr University Bochum (RUB))

Research History

• From Oct. 2023, To Present

  Kyoto University, Tenured Full Professor

Language of Instruction

• English
• Japanese

ID,URL

• ORCID ID

  0000-0002-4879-8782

• J-Global ID

  201601018148796807

• Researcher number

  30726477

Website(s) (URL(s))

• https://ashbi.kyoto-u.ac.jp/groups/alev/

researchmap URL

• https://researchmap.jp/alev.cantas

Research

Research Areas

• Life sciences, Developmental biology, In vitro models of embryonic development, human & primate embrology, organogenesis, mesoderm development, gastrulation

Papers

• Stress-induced CXCL13 regulates pancreatic exocrine homeostasis, age-related chronic inflammation, and cancer progression.

  Masahiro Yoshida; Kenichiro Furuyama; Keisuke Sumide; Masashi Horiguchi; Ahmed I Abo-Ahmed; Hirofumi Shibata; Akito Tanaka; Ahmed M Rashwan; Toshihiko Masui; Cantas Alev; Takuya Yamamoto; Yasuhiro Yamada; Shin Kaneko; Shuh Narumiya; David Tuveson; Shinji Uemoto; Etsuro Hatano; Yoshiya Kawaguchi

  Science advances, May 2026, Peer-reviewed

  Access this paper :

  
• Modeling Somitogenesis and Axial Development In Vitro with Axioloids.

  Keun-Tae Kim; Sofiane Hamidi; Cantas Alev

  Methods in molecular biology (Clifton, N.J.), 23 Apr. 2026, Peer-reviewed, Last author, Corresponding author

  
• Nuclear speckles enable processing of RNA from GC-rich isochores.

  Michał Małszycki; Lisa Martina; İbrahim Avşar Ilık; Daniela Salgado Figueroa; Nirmalya Dasgupta; Menşura Feray Çoşar; Keun-Tae Kim; Gil Carraco; Beatrix Fauler; David Meierhofer; Thorsten Mielke; Hiroo Imai; Cantaş Alev; Ferhat Ay; Tuğçe Aktaş

  Cell, 02 Apr. 2026, Peer-reviewed

  
• Human stem cell-based embryo models: innovation, ethics, and policy.

  Alfonso Martinez Arias; Nicolas Rivron; Shahragim Tajbakhsh; Josephine Johnston; Cantas Alev; Laure Bally-Cuif; Elvan Böke; Tommaso Cavazza; Emma Cave; David Cyranoski; Laurent David; Miguel A Esteban; Jianping Fu; Niels Geijsen; Nienke de Graeff; Jacob H Hanna; Nick Hopwood; Maneesha S Inamdar; Fredrik Lanner; Brigitte Leeners; Zhen Liu; Maitre Jean Leon; Gabriella Minchiotti; Naomi Moris; Megan Munsie; Kathy K Niakan; Olivier Pourquie; Vincent Pasque; Martin Pera; Yaojin Peng; Sophie Petropoulos; Sharad Ramanathan; Janet Rossant; Peter Rugg-Gunn; Mitinori Saitou; Karen Sermon; Jose Silva; Thorold Theunissen; Margherita Turco; John Wallingford; Hongmei Wang; Aryeh Warmflash; Jun Wu; Leqian Yu

  Human reproduction (Oxford, England), 24 Mar. 2026, Peer-reviewed

  
• Criteria for the standardization of stem-cell-based embryo models.

  Alfonso Martinez Arias; Nicolas Rivron; Naomi Moris; Patrick Tam; Cantas Alev; Jianping Fu; Anna-Katerina Hadjantonakis; Jacob H Hanna; Gabriella Minchiotti; Olivier Pourquie; Guojun Sheng; Liliana Solnica Krezel; Jesse V Veenvliet; Aryeh Warmflash

  Nature cell biology, Oct. 2024, Peer-reviewed

  
• The role of VEGF in the extremities

  Brendan A.S. McIntyre; Takayuki Asahara; Cantas Alev

  Therapeutic Angiogenesis, 11 Jul. 2017, Peer-reviewed, Last author, Corresponding author

  
• Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences.

  Daqi Yu; Yandong Ren; Masahiro Uesaka; Alan J S Beavan; Matthieu Muffato; Jieyu Shen; Yongxin Li; Iori Sato; Wenting Wan; James W Clark; Joseph N Keating; Emily M Carlisle; Richard P Dearden; Sam Giles; Emma Randle; Robert S Sansom; Roberto Feuda; James F Fleming; Fumiaki Sugahara; Carla Cummins; Mateus Patricio; Wasiu Akanni; Salvatore D'Aniello; Cristiano Bertolucci; Naoki Irie; Cantas Alev; Guojun Sheng; Alex de Mendoza; Ignacio Maeso; Manuel Irimia; Bastian Fromm; Kevin J Peterson; Sabyasachi Das; Masayuki Hirano; Jonathan P Rast; Max D Cooper; Jordi Paps; Davide Pisani; Shigeru Kuratani; Fergal J Martin; Wen Wang; Philip C J Donoghue; Yong E Zhang; Juan Pascual-Anaya

  Nature ecology & evolution, 12 Jan. 2024, Peer-reviewed

  
• In vitro models of pre- and post-gastrulation embryonic development.

  Sofiane Hamidi; Cantas Alev

  Current opinion in genetics & development, Dec. 2022, Peer-reviewed, Last author, Corresponding author

  
• eSPRESSO: topological clustering of single-cell transcriptomics data to reveal informative genes for spatio–temporal architectures of cells

  Tomoya Mori; Toshiro Takase; Kuan-Chun Lan; Junko Yamane; Cantas Alev; Azuma Kimura; Kenji Osafune; Jun K. Yamashita; Tatsuya Akutsu; Hiroaki Kitano; Wataru Fujibuchi

  BMC Bioinformatics, 15 Jun. 2023, Peer-reviewed

  Access this paper :

  
• Reconstituting human somitogenesis in vitro.

  Yoshihiro Yamanaka; Sofiane Hamidi; Kumiko Yoshioka-Kobayashi; Sirajam Munira; Kazunori Sunadome; Yi Zhang; Yuzuru Kurokawa; Rolf Ericsson; Ai Mieda; Jamie L Thompson; Janet Kerwin; Steven Lisgo; Takuya Yamamoto; Naomi Moris; Alfonso Martinez-Arias; Taro Tsujimura; Cantas Alev

  Nature, Feb. 2023, Peer-reviewed, Last author, Corresponding author

  
• Japan: prize diversity, not conformity, to boost research.

  Guojun Sheng; Piero Carninci; Mikiko C Siomi; Toshio Suda; Cantas Alev

  Nature, Nov. 2021, Invited, Last author

  
• Biomedical and societal impacts of in vitro embryo models of mammalian development.

  Naomi Moris; Cantas Alev; Martin Pera; Alfonso Martinez Arias

  Stem cell reports, 11 May 2021, Peer-reviewed, Lead author, Corresponding author

  Access this paper :

  
• Organoids: ready for the revolution?

  Bon-Kyoung Koo; Sina Bartfeld; Cantas Alev

  Journal of molecular medicine (Berlin, Germany), 29 Mar. 2021, Invited, Last author

  
• Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias.

  Yann Pretemer; Shunsuke Kawai; Sanae Nagata; Megumi Nishio; Makoto Watanabe; Sakura Tamaki; Cantas Alev; Yoshihiro Yamanaka; Jing-Yi Xue; Zheng Wang; Kenichi Fukiage; Masako Tsukanaka; Tohru Futami; Shiro Ikegawa; Junya Toguchida

  Stem cell reports, 09 Mar. 2021, Peer-reviewed

  Access this paper :

  
• Species-specific segmentation clock periods are due to differential biochemical reaction speeds.

  Mitsuhiro Matsuda; Hanako Hayashi; Jordi Garcia-Ojalvo; Kumiko Yoshioka-Kobayashi; Ryoichiro Kageyama; Yoshihiro Yamanaka; Makoto Ikeya; Junya Toguchida; Cantas Alev; Miki Ebisuya

  Science (New York, N.Y.), 18 Sep. 2020, Peer-reviewed

  
• Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells.

  Keishi Kishimoto; Kana T Furukawa; Agustin Luz-Madrigal; Akira Yamaoka; Chisa Matsuoka; Masanobu Habu; Cantas Alev; Aaron M Zorn; Mitsuru Morimoto

  Nature communications, 27 Aug. 2020, Peer-reviewed

  Access this paper :

  
• Recapitulating the human segmentation clock with pluripotent stem cells.

  Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Thomas L Maurissen; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Noriaki Kawakami; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev

  Nature, Apr. 2020, Peer-reviewed, Lead author, Last author, Corresponding author

  
• Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation.

  Hamidi S; Nakaya Y; Nagai H; Alev C; Kasukawa T; Chhabra S; Lee R; Niwa H; Warmflash A; Shibata T; Sheng G

  Development (Cambridge, England), Feb. 2020, Peer-reviewed

  
• Overview of Basic Mechanisms of Notch Signaling in Development and Disease.

  McIntyre B; Asahara T; Alev C

  Advances in experimental medicine and biology, Jan. 2020, Peer-reviewed, Last author, Corresponding author

  
• Bi-allelic loss of function variants of TBX6 causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis.

  Nao Otomo; Kazuki Takeda; Shunsuke Kawai; Ikuyo Kou; Long Guo; Mitsujiro Osawa; Cantas Alev; Noriaki Kawakami; Noriko Miyake; Naomichi Matsumoto; Yukuto Yasuhiko; Toshiaki Kotani; Teppei Suzuki; Koki Uno; Hideki Sudo; Satoshi Inami; Hiroshi Taneichi; Hideki Shigematsu; Kei Watanabe; Ikuho Yonezawa; Ryo Sugawara; Yuki Taniguchi; Shohei Minami; Kazuo Kaneko; Masaya Nakamura; Morio Matsumoto; Junya Toguchida; Kota Watanabe; Shiro Ikegawa

  Journal of medical genetics, Sep. 2019, Peer-reviewed

  
• Novel computational model of gastrula morphogenesis to identify spatial discriminator genes by self-organizing map (SOM) clustering.

  Tomoya Mori; Haruka Takaoka; Junko Yamane; Cantas Alev; Wataru Fujibuchi

  Scientific reports, 29 Aug. 2019, Peer-reviewed

  
• In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes.

  Shunsuke Kawai; Hiroyuki Yoshitomi; Junko Sunaga; Cantas Alev; Sanae Nagata; Megumi Nishio; Masataka Hada; Yuko Koyama; Maya Uemura; Kazuya Sekiguchi; Hirotsugu Maekawa; Makoto Ikeya; Sakura Tamaki; Yonghui Jin; Yuki Harada; Kenichi Fukiage; Taiji Adachi; Shuichi Matsuda; Junya Toguchida

  Nature biomedical engineering, Jul. 2019, Peer-reviewed

  
• Biomechanical regulation of EMT and epithelial morphogenesis in amniote epiblast.

  Sofiane Hamidi; Yukiko Nakaya; Hiroki Nagai; Cantas Alev; Tatsuo Shibata; Guojun Sheng

  Physical biology, 23 Apr. 2019, Peer-reviewed

  
• Twins at Conspicuously Different Developmental Stages in a Turtle Egg.

  Tatsuya Hirasawa; Cantas Alev; Shigeru Kuratani

  Zoological science, 01 Feb. 2019, Peer-reviewed

  
• Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells.

  Taiki Nakajima; Mitsuaki Shibata; Megumi Nishio; Sanae Nagata; Cantas Alev; Hidetoshi Sakurai; Junya Toguchida; Makoto Ikeya

  Development (Cambridge, England), 23 Aug. 2018, Peer-reviewed

  
• Early hematopoietic and vascular development in the chick.

  Hiroki Nagai; Masahiro Shin; Wei Weng; Fumie Nakazawa; Lars Martin Jakt; Cantas Alev; Guojun Sheng

  The International journal of developmental biology, 2018, Peer-reviewed

  
• Ex vivo expansion of circulating CD34(+) cells enhances the regenerative effect on rat liver cirrhosis.

  Toru Nakamura; Hironori Koga; Hideki Iwamoto; Victor Tsutsumi; Yasuko Imamura; Masako Naitou; Atsutaka Masuda; Yu Ikezono; Mitsuhiko Abe; Fumitaka Wada; Takahiko Sakaue; Takato Ueno; Masaaki Ii; Cantas Alev; Atsuhiko Kawamoto; Takayuki Asahara; Takuji Torimura

  Molecular therapy. Methods & clinical development, 2016, Peer-reviewed

  
• Serological targeted analysis of an ITIH4 peptide isoform: a preterm birth biomarker and its associated SNP implications.

  Zhou Tan; Zhongkai Hu; Emily Y Cai; Cantas Alev; Ting Yang; Zhen Li; Joyce Sung; Yasser Yehia El-Sayed; Gary M Shaw; David K Stevenson; Atul J Butte; Guojun Sheng; Karl G Sylvester; Harvey J Cohen; Xuefeng B Ling

  Journal of genetics and genomics = Yi chuan xue bao, 20 Sep. 2015, Peer-reviewed

  
• Characterization of the finch embryo supports evolutionary conservation of the naive stage of development in amniotes.

  Siu-Shan Mak; Cantas Alev; Hiroki Nagai; Anna Wrabel; Yoko Matsuoka; Akira Honda; Guojun Sheng; Raj K Ladher

  eLife, 11 Sep. 2015, Peer-reviewed

  
• Innate immune response of human pluripotent stem cell-derived airway epithelium.

  Brendan A S McIntyre; Rahul Kushwah; Rami Mechael; Zoya Shapovalova; Cantas Alev; Mickie Bhatia

  Innate immunity, Jul. 2015, Peer-reviewed

  
• Sonic Hedgehog signaling regulates vascular differentiation and function in human CD34 positive cells: vasculogenic CD34(+) cells with Sonic Hedgehog.

  Kurando Kanaya; Masaaki Ii; Teiji Okazaki; Toru Nakamura; Miki Horii-Komatsu; Cantas Alev; Hiroshi Akimaru; Atsuhiko Kawamoto; Hidetoshi Akashi; Hiroyuki Tanaka; Michio Asahi; Takayuki Asahara

  Stem cell research, Mar. 2015, Peer-reviewed

  
• Superior Potential of CD34-Positive Cells Compared to Total Mononuclear Cells for Healing of Nonunion Following Bone Fracture.

  Tomoaki Fukui; Yutaka Mifune; Tomoyuki Matsumoto; Taro Shoji; Yohei Kawakami; Atsuhiko Kawamoto; Masaaki Ii; Hiroshi Akimaru; Tomoya Kuroda; Miki Horii; Ayumi Yokoyama; Cantas Alev; Ryosuke Kuroda; Masahiro Kurosaka; Takayuki Asahara

  Cell transplantation, 2015, Peer-reviewed

  
• Expansive generation of functional airway epithelium from human embryonic stem cells.

  Brendan A S McIntyre; Cantas Alev; Rami Mechael; Kyle R Salci; Jung Bok Lee; Aline Fiebig-Comyn; Borhane Guezguez; Yuping Wu; Guojun Sheng; Mickie Bhatia

  Stem cells translational medicine, Jan. 2014, Peer-reviewed

  
• Decoupling of amniote gastrulation and streak formation reveals a morphogenetic unity in vertebrate mesoderm induction.

  Cantas Alev; Yuping Wu; Yukiko Nakaya; Guojun Sheng

  Development (Cambridge, England), Jul. 2013, Peer-reviewed

  
• Ex-vivo expanded human blood-derived CD133+ cells promote repair of injured spinal cord.

  Naosuke Kamei; Sang-Mo Kwon; Cantas Alev; Kazuyoshi Nakanishi; Kiyotaka Yamada; Haruchika Masuda; Masakazu Ishikawa; Atsuhiko Kawamoto; Mitsuo Ochi; Takayuki Asahara

  Journal of the neurological sciences, 15 May 2013, Peer-reviewed

  
• Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis.

  Brendan A S McIntyre; Veronica Ramos-Mejia; Shravanti Rampalli; Rami Mechael; Jong-Hee Lee; Cantas Alev; Guojun Sheng; Mickie Bhatia

  Blood, 28 Feb. 2013, Peer-reviewed

  
• Proteomic approaches for the study of electrical synapses and associated protein-interaction complexes

  Cantas Alev; Georg Zoidl; Rolf Dermietzel

  Neuromethods, 2013, Peer-reviewed

  
• 小さく獲得した原始線条 は虫類から見た鳥類の原腸形成(A little winning streak: The reptilian-eye view of gastrulation in birds)

  Bertocchini Federica; Alev Cantas; Nakaya Yukiko; Sheng Guojun

  Development, Growth & Differentiation, Jan. 2013

  
• Peptidomic Identification of Serum Peptides Diagnosing Preeclampsia.

  Qiaojun Wen; Linda Y Liu; Ting Yang; Cantas Alev; Shuaibin Wu; David K Stevenson; Guojun Sheng; Atul J Butte; Xuefeng B Ling

  PloS one, 2013, Peer-reviewed

  
• Manipulating the avian epiblast and epiblast-derived stem cells.

  Cantas Alev; Mikiharu Nakano; Yuping Wu; Hiroyuki Horiuchi; Guojun Sheng

  Methods in molecular biology (Clifton, N.J.), 2013, Peer-reviewed

  
• The molecular basis of Notch signaling: a brief overview.

  Sang-Mo Kwon; Cantas Alev; Sang-Hun Lee; Takayuki Asahara

  Advances in experimental medicine and biology, 2012, Peer-reviewed

  
• Local transplantation of ex vivo expanded bone marrow-derived CD34-positive cells accelerates fracture healing.

  Yohei Kawakami; Masaaki Ii; Cantas Alev; Atsuhiko Kawamoto; Tomoyuki Matsumoto; Ryosuke Kuroda; Taro Shoji; Tomoaki Fukui; Haruchika Masuda; Hiroshi Akimaru; Yutaka Mifune; Tomoya Kuroda; Miki Horii; Ayumi Yokoyama; Masahiro Kurosaka; Takayuki Asahara

  Cell transplantation, 2012, Peer-reviewed

  
• Endothelial progenitor cells: a novel tool for the therapy of ischemic diseases.

  Cantas Alev; Masaaki Ii; Takayuki Asahara

  Antioxidants & redox signaling, 15 Aug. 2011, Peer-reviewed

  
• Yolk sac endoderm is the major source of serum proteins and lipids and is involved in the regulation of vascular integrity in early chick development.

  Fumie Nakazawa; Cantas Alev; Lars M Jakt; Guojun Sheng

  Developmental dynamics : an official publication of the American Association of Anatomists, Aug. 2011, Peer-reviewed

  
• Methodological development of a clonogenic assay to determine endothelial progenitor cell potential.

  Haruchika Masuda; Cantas Alev; Hiroshi Akimaru; Rie Ito; Tomoko Shizuno; Michiru Kobori; Miki Horii; Toshiya Ishihara; Kazuya Isobe; Mitsuhiro Isozaki; Johbu Itoh; Yoshiko Itoh; Yoshinori Okada; Brendan A S McIntyre; Shunichi Kato; Takayuki Asahara

  Circulation research, 24 Jun. 2011, Peer-reviewed

  
• Activin/TGF-beta signaling regulates Nanog expression in the epiblast during gastrulation

  Masahiro Shin; Cantas Alev; Yuping Wu; Hiroki Nagai; Guojun Sheng

  Mechanisms of Development, May 2011, Peer-reviewed

  
• Identification of region-specific genes in the early chicken endoderm

  Wataru Kimura; Cantas Alev; Guojun Sheng; Martin Jakt; Sadao Yasugi; Kimiko Fukuda

  Gene Expression Patterns, Mar. 2011, Peer-reviewed

  
• Involvement of dystroglycan in epithelial-mesenchymal transition during chick gastrulation.

  Yukiko Nakaya; Erike W Sukowati; Cantas Alev; Fumie Nakazawa; Guojun Sheng

  Cells, tissues, organs, 2011, Peer-reviewed

  
• CD34+ cells represent highly functional endothelial progenitor cells in murine bone marrow.

  Junjie Yang; Masaaki Ii; Naosuke Kamei; Cantas Alev; Sang-Mo Kwon; Atsuhiko Kawamoto; Hiroshi Akimaru; Haruchika Masuda; Yoshiki Sawa; Takayuki Asahara

  PloS one, 2011, Peer-reviewed

  
• Transcriptomic landscape of the primitive streak.

  Cantas Alev; Yuping Wu; Takeya Kasukawa; Lars M Jakt; Hiroki R Ueda; Guojun Sheng

  Development (Cambridge, England), 01 Sep. 2010, Peer-reviewed

  
• Lnk deletion reinforces the function of bone marrow progenitors in promoting neovascularization and astrogliosis following spinal cord injury.

  Naosuke Kamei; Sang-Mo Kwon; Cantas Alev; Masakazu Ishikawa; Ayumi Yokoyama; Kazuyoshi Nakanishi; Kiyotaka Yamada; Miki Horii; Hiromi Nishimura; Satoshi Takaki; Atsuhiko Kawamoto; Masaaki Ii; Hiroshi Akimaru; Nobuhiro Tanaka; Shin-Ichi Nishikawa; Mitsuo Ochi; Takayuki Asahara

  Stem cells (Dayton, Ohio), Feb. 2010, Peer-reviewed

  
• Dynamic expression of Endoglin, a TGF-beta co-receptor, during pre-circulation vascular development in chick.

  Cantas Alev; Brendan A S McIntyre; Kanako Ota; Guojun Sheng

  The International journal of developmental biology, 2010, Peer-reviewed

  
• Genomic organization of zebra finch alpha and beta globin genes and their expression in primitive and definitive blood in comparison with globins in chicken.

  Cantas Alev; Kaori Shinmyozu; Brendan A S McIntyre; Guojun Sheng

  Development genes and evolution, Jul. 2009, Peer-reviewed

  
• The Role of Notch Signaling in Endothelial Progenitor Cell Biology

  Sang Mo Kwon; Cantas Alev; Takayuki Asahara

  Trends in Cardiovascular Medicine, Jul. 2009, Peer-reviewed

  
• NFATc2 Ser170 phosphorylation marks mitosis in development and ES cells.

  Cantas Alev; Yuping Wu; Fumie Nakazawa; Takayuki Asahara; Guojun Sheng

  Cell cycle (Georgetown, Tex.), 01 Jun. 2009, Peer-reviewed

  
• PBRL, a putative peripheral benzodiazepine receptor, in primitive erythropoiesis.

  Fumie Nakazawa; Cantas Alev; Masahiro Shin; Yukiko Nakaya; Lars M Jakt; Guojun Sheng

  Gene expression patterns : GEP, Feb. 2009, Peer-reviewed

  
• The neuronal connexin36 interacts with and is phosphorylated by CaMKII in a way similar to CaMKII interaction with glutamate receptors.

  Cantas Alev; Stephanie Urschel; Stephan Sonntag; Georg Zoidl; Alfredo G Fort; Thorsten Höher; Mamoru Matsubara; Klaus Willecke; David C Spray; Rolf Dermietzel

  Proceedings of the National Academy of Sciences of the United States of America, 30 Dec. 2008, Peer-reviewed

  
• BetaA, the major beta globin in definitive red blood cells, is present from the onset of primitive erythropoiesis in chicken.

  Cantas Alev; Brendan A S McIntyre; Hiroki Nagai; Masahiro Shin; Kaori Shinmyozu; Lars M Jakt; Guojun Sheng

  Developmental dynamics : an official publication of the American Association of Anatomists, Apr. 2008, Peer-reviewed

  
• Expression profiling of circulating non-red blood cells in embryonic blood.

  Brendan A S McIntyre; Cantas Alev; Hiroshi Tarui; Lars M Jakt; Guojun Sheng

  BMC developmental biology, 27 Feb. 2008, Peer-reviewed

  
• Protein kinase A-mediated phosphorylation of connexin36 in mouse retina results in decreased gap junctional communication between AII amacrine cells.

  Stephanie Urschel; Thorsten Höher; Timm Schubert; Cantas Alev; Goran Söhl; Philipp Wörsdörfer; Takayuki Asahara; Rolf Dermietzel; Reto Weiler; Klaus Willecke

  The Journal of biological chemistry, 03 Nov. 2006, Peer-reviewed

  

Misc.

• 創薬応用を目指したヒトiPS細胞によるin vitro骨形成過程再現系の構築

  川井 俊介; 吉富 啓之; 須長 純子; Alev Cantas; 永田 早苗; 西尾 恵; 羽田 匡孝; 吹上 謙一; 安達 泰治; 松田 秀一; 戸口田 淳也

  日本整形外科学会雑誌, Aug. 2018

  
• 家族性OPLL患者由来のiPS細胞を用いたOPLL遺伝的要素の検討

  川井 俊介; 羽田 匡孝; 小山 優子; 池谷 真; Alev Cantas; 堀田 秋津; 池川 志郎; 中村 雅也; 松本 守雄; 吉富 啓之; 松田 秀一; 戸口田 淳也

  日本整形外科学会雑誌, Aug. 2016

  

Presentations

• Towards reconstituting human and primate embryonic development in vitro

  The 12th Takeda Science Foundation Symposium on Pharmasciences - Organoid 4D - Development, Disease, Diversity and Discovery, 24 Jan. 2026, Invited

  
• Towards reconstituting early human embryonic development and disease in vitro

  Cantas Alev

  Annual Meeting of the Belgian Society for Stem Cell Research (BeSSCR 2025), 28 Nov. 2025, Invited

  
• Towards reconstituting human post-gastrulation development in vitro

  Cantas Alev

  Gastrulation Reloaded: Developing, engineering and evolving the body plan, 14 Oct. 2025, Invited

  
• Towards in vitro reconstitution of human and non-human primate early embryonic development

  Cold Spring Harbor Asia Conference: Human Development — From Embryos to Stem Cell Models, 22 Sep. 2025, Invited

  
• Towards reconstituting human and non-human primate axial development in vitro

  Cantas Alev

  10th Annual Meeting of the German Stem Cell Network (GSCN), 25 Sep. 2024, Invited

  
• Modeling Development & Disease in Axioloids

  Keystone Symposium - Stem Cell Models for Embryology, Pacific Groove, USA, 08 Feb. 2024, Invited

  
• Towards reconstituting axial development in vitro

  2023 Vienna International ISSCR Symposium - Elucidating the principles of development with stem cells., 06 Dec. 2023

  
• Reconstituting human somitogenesis & axial development in vitro

  Cold Spring Harbor Asia (CSHA) Symposium - Human Development – From Embryos to Stem Cell Models, 08 Mar. 2023, Invited

  

Media Coverage

• AMED ASPIRE Japan-UK Joint Research - Cantas Alev

  YouTube, https://www.youtube.com/watch?v=u5H-KCts4q4, Feb. 2026, Internet

  
• Sculpting the human body plan in a dish

  EurekAlert, https://www.eurekalert.org/news-releases/975082, Dec. 2022, Internet

  
• ‘Artificial embryos’: the hidden steps in forming a spine

  Nature, Nature Video, https://www.nature.com/articles/d41586-022-04560-0, Dec. 2022, Internet

  
• Reconstructing the clock of human development

  EurekAlert, https://www.eurekalert.org/pub_releases/2020-04/ku-rtc032620.php, Apr. 2020, Internet

  
• The clock that controls spine development modelled in a dish

  Nature, https://www.nature.com/articles/d41586-020-00322-y?draft=journal&proof=t, Apr. 2020, Paper

  

External funds: Kakenhi

• Induction of tendon/ligament progenitor cells from human iPSCs

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  CANTAS ALEV

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  Tendon Progenitor Cell;iPSCs;Mesoderm Differentiation;tendon progenitor cells;mesoderm differentiation;syndetome;Tendon Progenitor Cells;iPS細胞;腱誘導;中胚葉誘導;スクレラキシス;リポーター細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15664/
• Development of a xeno-free induction and maintenance protocol for MSCs from PSCs

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Makoto IKEYA

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  間葉系幹細胞;再生医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05447/
• Reconstituting human axial development in vitro

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields

  Kyoto University

  ALEV CANTAS

  From 01 Apr. 2024, To 31 Mar. 2029, Granted

  in vitro embro model;human development;organogenesis;axioloid;embryo model;primate development;neurulation;somitogenesis;notochord;organoid;in vitro embryo model;mesoderm development;neural development;ヒト胚発⽣;体外胚モデル;オルガノイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24H00569/

Education

Participation in PhD Defense

• iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome

  HIRAYAMA RYUICHIRO, Graduate School of Medicine, Sub-chief Examiner

  23 Jul. 2025
• Growth pattern of the de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment

  LIN YI-KAI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2025
• Generation of germinal-vesicle oocytes from mouse embryonic stem cells under an ovarian soma-free condition

  NOSAKA YOSHIAKI, Graduate School of Medicine, Sub-chief Examiner

  25 Nov. 2025
• HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes

  AKAGI KENTARO, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2025

Academic, Social Contribution

Academic Contribution

• Symposium “Human Development – From Embryos to Stem Cell Models"

  Planning, management, etc., Panel moderator, Other

  Cold Spring Harbor Asia (CSHA), From 05 Mar. 2023, To 10 Mar. 2023

  
• [SNF] Swiss National Science Foundation (Switzerland)

  Supervision (editorial)

  
• Cell Stem Cell

  Peer review

  
• Developmental Cell

  Peer review

  
• Nature Reviews Molecular and Cell Biology

  Peer review

  
• [ERC] European Research Council (EU)

  Supervision (editorial)

  
• Science

  Peer review

  
• Cell

  Peer review

  
• Nature Cell Biology

  Peer review

  
• Nature

  Peer review