Basic Information

Faculty

• Faculty of Engineering

Academic Degree

• 1998

  博士（理学）（東京大学）

Academic Resume (Graduate Schools)

• 東京大学, 大学院理学系研究科, 生物化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 理学部, 生物化学科, 卒業

Research History

• From Dec. 2022, To Present

  京都大学, 大学院工学研究科, 教授
• From Oct. 2011, To Nov. 2022

  大阪大学, 微生物病研究所, 教授
• From Apr. 2007, To Sep. 2011

  大阪大学, 蛋白質研究所, 教授
• From Feb. 2002, To Mar. 2007

  東京大学, 医科学研究所, 助教授
• From Apr. 1998, To Jan. 2002

  東京大学, 医科学研究所, 助手

ID,URL

• J-Global ID

  200901017509075164

• Researcher number

  80302602

researchmap URL

• https://researchmap.jp/read0056900

Research

Papers

• Phosphatase‐independent role of phosphatase of regenerating liver in cancer progression

  Yosuke Funato; Osamu Hashizume; Hiroaki Miki

  Cancer Science, Jan. 2023, Peer-reviewed, Last author, Corresponding author

  
• PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis

  Kajung Ryu; Atsushi Yoshida; Yosuke Funato; Daisuke Yamazaki; Hiroaki Miki

  Cell Structure and Function, Dec. 2022, Peer-reviewed, Last author

  
• A novel role for PRL in regulating epithelial cell density by inducing apoptosis at confluence.

  Sweksha Lohani; Yosuke Funato; Yuki Akieda; Kiyohito Mizutani; Yoshimi Takai; Tohru Ishitani; Hiroaki Miki

  Journal of cell science, 15 Jan. 2022, Peer-reviewed, Last author, Corresponding author

  
• The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters.

  Yosuke Funato; Hiroaki Miki

  Journal of pharmacological sciences, Jan. 2022, Peer-reviewed, Invited, Last author, Corresponding author

  
• Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.

  Shintaro Okumura; Yusuke Konishi; Megumi Narukawa; Yuki Sugiura; Shin Yoshimoto; Yuriko Arai; Shintaro Sato; Yasuo Yoshida; Shunya Tsuji; Ken Uemura; Masahiro Wakita; Tatsuyuki Matsudaira; Tomonori Matsumoto; Shimpei Kawamoto; Akiko Takahashi; Yoshiro Itatani; Hiroaki Miki; Manabu Takamatsu; Kazutaka Obama; Kengo Takeuchi; Makoto Suematsu; Naoko Ohtani; Yosuke Fukunaga; Masashi Ueno; Yoshiharu Sakai; Satoshi Nagayama; Eiji Hara

  Nature communications, 28 Sep. 2021, Peer-reviewed

  
• Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.

  Yosuke Funato; Daisuke Yamazaki; Daisuke Okuzaki; Nobuhiko Yamamoto; Hiroaki Miki

  Nature communications, 17 Jun. 2021, Peer-reviewed, Last author, Corresponding author

  
• Identification and mechanistic analysis of an inhibitor of the CorC Mg2+ transporter

  Yichen Huang; Kaijie Mu; Xinyu Teng; Yimeng Zhao; Yosuke Funato; Hiroaki Miki; Weiliang Zhu; Zhijian Xu; Motoyuki Hattori

  iScience, Apr. 2021, Peer-reviewed

  
• Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity

  Kalle Gehring; Hiroaki Miki

  British Journal of Cancer, 16 Mar. 2021, Peer-reviewed, Last author

  
• Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture

  Daisuke Yamazaki; Osamu Hashizume; Shiho Taniguchi; Yosuke Funato; Hiroaki Miki

  Scientific Reports, 17 Feb. 2021, Peer-reviewed, Last author, Corresponding author

  
• Structural basis for the Mg²⁺ recognition and regulation of the CorC Mg²⁺ transporter

  Yichen Huang; Fei Jin; Yosuke Funato; Zhijian Xu; Weiliang Zhu; Jing Wang; Minxuan Sun; Yimeng Zhao; Ye Yu; *Hiroaki Miki (co-correspondence); *Motoyuki Hattori

  Science Advances, 10 Feb. 2021, Peer-reviewed, Corresponding author

  
• Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

  Yanying Wu; Yosuke Funato; Eleonora Meschi; Kristijan D Jovanoski; Hiroaki Miki; Scott Waddell

  eLife, 26 Nov. 2020, Peer-reviewed

  
• The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis

  Yosuke Funato; Atsushi Yoshida; Yusuke Hirata; Osamu Hashizume; Daisuke Yamazaki; Hiroaki Miki

  Developmental Cell, 23 Nov. 2020, Peer-reviewed, Last author, Corresponding author

  
• PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth

  Guennadi Kozlov; Yosuke Funato; Yu Seby Chen; Zhidian Zhang; Katalin Illes; Hiroaki Miki; Kalle Gehring

  Journal of Biological Chemistry, 14 Aug. 2020, Peer-reviewed

  
• Excessive Mg²⁺ Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species

  Osamu Hashizume; Yosuke Funato; Daisuke Yamazaki; Hiroaki Miki

  Antioxidants and Redox Signaling, 01 Jul. 2020, Peer-reviewed, Last author, Corresponding author

  
• Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress

  Moe Matsushita; Takanori Nakamura; Hisashi Moriizumi; Hiroaki Miki; Mutsuhiro Takekawa

  Science Advances, Jun. 2020, Peer-reviewed

  
• P18/lamtor1-mtorc1 signaling controls development of mucin-producing goblet cells in the intestine

  Shizuka Ito; Shigeyuki Nada; Daisuke Yamazaki; Tetsuya Kimura; Kentaro Kajiwara; Hiroaki Miki; Masato Okada

  Cell Structure and Function, 2020, Peer-reviewed

  
• Control of protein function through oxidation and reduction of persulfidated states

  Dóka; T. Ida; M. Dagnell; Y. Abiko; N. C. Luong; N. Balog; T. Takata; B. Espinosa; A. Nishimura; Q. Cheng; Y. Funato; H. Miki; J. M. Fukuto; J. R. Prigge; E. E. Schmidt; E. S.J. Arnér; Y. Kumagai; T. Akaike; P. Nagy

  Science Advances, 01 Jan. 2020, Peer-reviewed

  
• Phosphatase of regenerating liver sensitizes MET to functional activation by hepatocyte growth factor

  Takuya Kojima; Yosuke Funato; Hiroaki Miki

  Biochemical Journal, 21 May 2019, Peer-reviewed, Last author, Corresponding author

  
• Cnnm4 deficiency suppresses Ca²⁺ signaling and promotes cell proliferation in the colon epithelia

  Daisuke Yamazaki; Ayaka Hasegawa; Yosuke Funato; Ha Nam Tran; Masayuki X. Mori; Yasuo Mori; Toshiro Sato; Hiroaki Miki

  Oncogene, 16 May 2019, Peer-reviewed, Last author, Corresponding author

  
• Molecular function and biological importance of CNNM family Mg ²⁺ transporters

  Yosuke Funato; Hiroaki Miki

  Journal of Biochemistry, 01 Mar. 2019, Peer-reviewed, Last author, Corresponding author

  
• The cyclic nucleotide– binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg² efflux activity

  Yu Seby Chen; Guennadi Kozlov; Rayan Fakih; Yosuke Funato; Hiroaki Miki; Kalle Gehring

  Journal of Biological Chemistry, 28 Dec. 2018, Peer-reviewed

  
• Phosphatase of regenerating liver maintains cellular magnesium homeostasis

  Atsushi Yoshida; Yosuke Funato; Hiroaki Miki

  Biochemical Journal, 30 Mar. 2018, Peer-reviewed, Last author, Corresponding author

  
• CrossTalk proposal: CNNM proteins are Na ⁺ /Mg ²⁺ exchangers playing a central role in transepithelial Mg ²⁺ (re)absorption

  Yosuke Funato; Kazuharu Furutani; Yoshihisa Kurachi; Hiroaki Miki

  Journal of Physiology, 01 Mar. 2018, Peer-reviewed, Last author, Corresponding author

  
• Renal function of cyclin M2 Mg²⁺ transporter maintains blood pressure

  Yosuke Funato; Daisuke Yamazaki; Hiroaki Miki

  Journal of Hypertension, 2017, Peer-reviewed, Last author, Corresponding author

  
• Visualization of long-term Mg²⁺ dynamics in apoptotic cells using a novel targetable fluorescent probe

  Yusuke Matsui; Yosuke Funato; Hiromi Imamura; Hiroaki Miki; Shin Mizukami; Kazuya Kikuchi

  Chemical Science, 2017, Peer-reviewed

  
• Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis

  Irina Gulerez; Yosuke Funato; Howie Wu; Meng Yang; Guennadi Kozlov; *Hiroaki Miki (co-correspondence); *Kalle Gehring

  EMBO REPORTS, Dec. 2016, Peer-reviewed, Corresponding author

  
• Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans

  Tasuku Ishii; Yosuke Funato; Osamu Hashizume; Daisuke Yamazaki; Yusuke Hirata; Kiyoji Nishiwaki; Nozomu Kono; Hiroyuki Arai; Hiroaki Miki

  PLoS Genetics, 01 Aug. 2016, Peer-reviewed, Last author, Corresponding author

  
• Complementary role of CNNM2 in sperm motility and Ca2+ influx during capacitation

  Daisuke Yamazaki; Yosuke Funato; Haruhiko Miyata; Masahito Ikawa; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2016, Peer-reviewed, Last author, Corresponding author

  
• The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction

  Daisuke Yamazaki; Haruhiko Miyata; Yosuke Funato; Yoshitaka Fujihara; Masahito Ikawa; Hiroaki Miki

  JOURNAL OF CELL SCIENCE, May 2016, Peer-reviewed, Last author, Corresponding author

  
• Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression

  Yosuke Funato; Daisuke Yamazaki; Shin Mizukami; Lisa Du; Kazuya Kikuchi; Hiroaki Miki

  JOURNAL OF CLINICAL INVESTIGATION, Dec. 2014, Peer-reviewed, Last author, Corresponding author

  
• Basolateral sorting of the Mg2+ transporter CNNM4 requires interaction with AP-1A and AP-1B

  Yusuke Hirata; Yosuke Funato; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2014, Peer-reviewed, Last author, Corresponding author

  
• Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data

  Katsuyuki Yugi; Hiroyuki Kubota; Yu Toyoshima; Rei Noguchi; Kentaro Kawata; Yasunori Komori; Shinsuke Uda; Katsuyuki Kunida; Yoko Tomizawa; Yosuke Funato; Hiroaki Miki; Masaki Matsumoto; Keiichi I. Nakayama; Kasumi Kashikura; Keiko Endo; Kazutaka Ikeda; Tomoyoshi Soga; Shinya Kuroda

  CELL REPORTS, Aug. 2014, Peer-reviewed

  
• Mg2+ -dependent Interactions of ATP with the Cystathionine-beta-Synthase (CBS) Domains of a Magnesium Transporter

  Yusuke Hirata; Yosuke Funato; Yu Takano; Hiroaki Miki

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2014, Peer-reviewed, Last author, Corresponding author

  
• Reversible oxidation of PRL family protein-tyrosine phosphatases

  Yosuke Funato; Hiroaki Miki

  METHODS, Jan. 2014, Peer-reviewed, Last author, Corresponding author

  
• SrGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity

  Daisuke Yamazaki; Toshiki Itoh; Hiroaki Miki; Tadaomi Takenawa

  Molecular Biology of the Cell, 01 Nov. 2013, Peer-reviewed

  
• Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1

  Yosuke Funato; Tatsuya Hayashi; Yasuhiro Irino; Tadaomi Takenawa; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2013, Peer-reviewed, Last author, Corresponding author

  
• Thioredoxin-related Protein 32 (TRP32) Specifically Reduces Oxidized Phosphatase of Regenerating Liver (PRL)

  Tasuku Ishii; Yosuke Funato; Hiroaki Miki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2013, Peer-reviewed, Last author, Corresponding author

  
• [Redox-dependent regulation of intracellular signaling via nucleoredoxin].

  Funato Y; Miki H

  Seikagaku. The Journal of Japanese Biochemical Society, Mar. 2013, Peer-reviewed, Last author, Corresponding author

  
• Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model

  Daisuke Yamazaki; Yosuke Funato; Jiro Miura; Sunao Sato; Satoru Toyosawa; Kazuharu Furutani; Yoshihisa Kurachi; Yoshihiro Omori; Takahisa Furukawa; Tetsuya Tsuda; Susumu Kuwabata; Shin Mizukami; Kazuya Kikuchi; Hiroaki Miki

  PLoS Genetics, 2013, Peer-reviewed, Last author, Corresponding author

  
• Phosphorylation of Kif26b Promotes Its Polyubiquitination and Subsequent Proteasomal Degradation during Kidney Development

  Takeshi Terabayashi; Masaji Sakaguchi; Kaori Shinmyozu; Toshio Ohshima; Ai Johjima; Teru Ogura; Hiroaki Miki; Ryuichi Nishinakamura

  PLOS ONE, Jun. 2012, Peer-reviewed

  
• Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species

  Hiroaki Miki; Yosuke Funato

  JOURNAL OF BIOCHEMISTRY, Mar. 2012, Peer-reviewed, Lead author, Corresponding author

  
• Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis

  A. Morinaka; Y. Funato; K. Uesugi; H. Miki

  ONCOGENE, Oct. 2011, Peer-reviewed, Last author, Corresponding author

  
• Dynamic regulation of GEF-H1 localization at microtubules by Par1b/MARK2

  Yuta Yoshimura; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, Peer-reviewed, Last author, Corresponding author

  
• Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse

  Akifumi Morinaka; Mayumi Yamada; Rurika Itofusa; Yosuke Funato; Yuta Yoshimura; Fumio Nakamura; Takeshi Yoshimura; Kozo Kaibuchi; Yoshio Goshima; Mikio Hoshino; Hiroyuki Kamiguchi; Hiroaki Miki

  Science Signaling, 26 Apr. 2011, Peer-reviewed, Last author, Corresponding author

  
• An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease

  Linda Müller; Yosuke Funato; Hiroaki Miki; Richard Zimmermann

  FEBS Letters, 18 Feb. 2011, Peer-reviewed

  
• Nucleoredoxin Sustains Wnt/beta-Catenin Signaling by Retaining a Pool of Inactive Dishevelled Protein

  Yosuke Funato; Takeshi Terabayashi; Reiko Sakamoto; Daisuke Okuzaki; Hirotake Ichise; Hiroshi Nojima; Nobuaki Yoshida; Hiroaki Miki

  CURRENT BIOLOGY, Nov. 2010, Peer-reviewed, Last author, Corresponding author

  
• Nucleoredoxin Negatively Regulates Toll-like Receptor 4 Signaling via Recruitment of Flightless-I to Myeloid Differentiation Primary Response Gene (88)

  Tatsuya Hayashi; Yosuke Funato; Takeshi Terabayashi; Akifumi Morinaka; Reiko Sakamoto; Hirotake Ichise; Hiroyuki Fukuda; Nobuaki Yoshida; Hiroaki Miki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2010, Peer-reviewed, Last author, Corresponding author

  
• Par1b/MARK2 Phosphorylates Kinesin-Like Motor Protein GAKIN/KIF13B To Regulate Axon Formation

  Yuta Yoshimura; Takeshi Terabayashi; Hiroaki Miki

  MOLECULAR AND CELLULAR BIOLOGY, May 2010, Peer-reviewed, Last author, Corresponding author

  
• Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme

  Yukako Uchiyama; Masaji Sakaguchi; Takeshi Terabayashi; Toshiaki Inenaga; Shuji Inoue; Chiyoko Kobayashi; Naoko Oshima; Hiroshi Kiyonari; Naomi Nakagata; Yuya Sato; Kiyotoshi Sekiguchi; Hiroaki Miki; Eiichi Araki; Sayoko Fujimura; Satomi S. Tanaka; Ryuichi Nishinakamura

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2010, Peer-reviewed

  
• Redox regulation of Wnt signalling via nucleoredoxin

  Yosuke Funato; Hiroaki Miki

  FREE RADICAL RESEARCH, Apr. 2010, Peer-reviewed, Last author, Corresponding author

  
• Discovery of Candidate Disease Genes in ENU-Induced Mouse Mutants by Large-Scale Sequencing, Including a Splice-Site Mutation in Nucleoredoxin

  Melissa K. Boles; Bonney M. Wilkinson; Laurens G. Wilming; Bin Liu; Frank J. Probst; Jennifer Harrow; Darren Grafham; Kathryn E. Hentges; Lanette P. Woodward; Andrea Maxwell; Karen Mitchell; Michael D. Risley; Randy Johnson; Karen Hirschi; James R. Lupski; Yosuke Funato; Hiroaki Miki; Pablo Marin-Garcia; Lucy Matthews; Alison J. Coffey; Anne Parker; Tim J. Hubbard; Jane Rogers; Allan Bradley; David J. Adams; Monica J. Justice

  PLOS GENETICS, Dec. 2009, Peer-reviewed

  
• Sufu recruits GSK3 beta for efficient processing of Gli3

  Yoshiaki Kise; Akifumi Morinaka; Stephan Teglund; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2009, Peer-reviewed, Last author, Corresponding author

  
• A Coated Vesicle-associated Kinase of 104 kDa (CVAK104) Induces Lysosomal Degradation of Frizzled 5 (Fzd5)

  Takeshi Terabayashi; Yosuke Funato; Mitsunori Fukuda; Hiroaki Miki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2009, Peer-reviewed, Last author, Corresponding author

  
• Dishevelled-induced phosphorylation regulates membrane localization of Par1b

  Takeshi Terabayashi; Yosuke Funato; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2008, Peer-reviewed, Last author, Corresponding author

  
• Nucleoredoxin regulates the Wnt/planar cell polarity pathway in Xenopus

  Yosuke Funato; Tatsuo Michiue; Takeshi Terabayashi; Akira Yukita; Hiroki Danno; Makoto Asashima; Hiroaki Miki

  GENES TO CELLS, Sep. 2008, Peer-reviewed, Last author, Corresponding author

  
• Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons

  Takeshi Terabayashi; Tomohiko J. Itoh; Hideki Yamaguchi; Yuta Yoshimura; Yosuke Funato; Shigeo Ohno; Hiroaki Miki

  JOURNAL OF NEUROSCIENCE, Nov. 2007, Peer-reviewed, Last author, Corresponding author

  
• Nucleoredoxin, a novel thioredoxin family member involved in cell growth and differentiation

  Yosuke Funato; Hiroaki Miki

  ANTIOXIDANTS & REDOX SIGNALING, Aug. 2007, Peer-reviewed, Last author, Corresponding author

  
• Regulation of Wnt signal pathway via nucleoredoxin

  Yosuke Funato; Hiroaki Miki

  SEIKAGAKU, Aug. 2007, Peer-reviewed, Last author, Corresponding author

  
• GSK3 beta positively regulates Hedgehog signaling through Sufu in mammalian cells

  Kei Takenaka; Yoshiaki Kise; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2007, Peer-reviewed, Last author, Corresponding author

  
• Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus

  Daiju Tsuchiya; Yoshihisa Kitamura; Kazuyuki Takata; Tatsuhiko Sugisaki; Takashi Taniguchi; Kengo Uemura; Hiroaki Miki; Tadaomi Takenawa; Shun Shimohama

  NEUROSCIENCE RESEARCH, Dec. 2006, Peer-reviewed

  
• Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels

  Yoshiaki Kise; Kei Takenaka; Tohru Tezuka; Tadashi Yamamoto; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2006, Peer-reviewed, Last author, Corresponding author

  
• Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells

  Daiju Tsuchiya; Yoshihisa Kitamura; Kazuyuki Takata; Takashi Taniguchi; Kengo Uemura; Hiroaki Miki; Tadaorni Takenawa; Shun Shimohama

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Nov. 2006, Peer-reviewed

  
• The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled

  Y Funato; T Michiue; M Asashima; H Miki

  NATURE CELL BIOLOGY, May 2006, Peer-reviewed, Last author, Corresponding author

  
• WAVE/scars in platelets

  A Oda; H Miki; Wada, I; H Yamaguchi; D Yamazaki; S Suetsugu; M Nakajima; A Nakayama; K Okawa; H Miyazaki; K Matsuno; HD Ochs; LM Machesky; H Fujita; T Takenawa

  BLOOD, Apr. 2005, Peer-reviewed

  
• WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor

  H Bierne; H Miki; M Innocenti; G Scita; FB Gertler; T Takenawa; P Cossart

  JOURNAL OF CELL SCIENCE, Apr. 2005, Peer-reviewed

  
• Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

  H Yamaguchi; M Lorenz; S Kempiak; C Sarmiento; S Coniglio; M Symons; J Segall; R Eddy; H Miki; T Takenawa; J Condeelis

  JOURNAL OF CELL BIOLOGY, Jan. 2005, Peer-reviewed

  
• N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor

  K Kawamura; K Takano; S Suetsugu; S Kurisu; D Yamazaki; H Miki; T Takenawa; T Endo

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2004, Peer-reviewed

  
• The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein

  K Takenaka; H Nakagawa; S Miyamoto; H Miki

  BIOCHEMICAL JOURNAL, Aug. 2004, Peer-reviewed, Last author, Corresponding author

  
• Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts

  S Verma; AM Shewan; JA Scott; FM Helwani; NR den Elzen; H Miki; T Takenawa; AS Yap

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2004, Peer-reviewed

  
• IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness

  Y Funato; T Terabayashi; N Suenaga; M Seiki; T Takenawa; H Miki

  CANCER RESEARCH, Aug. 2004, Peer-reviewed, Last author, Corresponding author

  
• Regulation of actin dynamics by WASP family proteins

  H Miki; T Takenawa

  JOURNAL OF BIOCHEMISTRY, Sep. 2003, Peer-reviewed, Lead author

  
• Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease

  Y Kitamura; D Tsuchiya; K Takata; K Shibagaki; T Taniguchi; MA Smith; G Perry; H Miki; T Takenawa; S Shimohama

  NEUROSCIENCE LETTERS, Aug. 2003, Peer-reviewed

  
• WAVE2 is required for directed cell migration and cardiovascular development

  D Yamazaki; S Suetsugu; H Miki; Y Kataoka; SI Nishikawa; T Fujiwara; N Yoshida; T Takenawa

  NATURE, Jul. 2003, Peer-reviewed

  
• IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena

  H Nakagawa; H Miki; M Nozumi; T Takenawa; S Miyamoto; J Wehland; JV Small

  JOURNAL OF CELL SCIENCE, Jun. 2003, Peer-reviewed

  
• Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia

  Y Kitamura; K Shibagaki; K Takata; D Tsuchiya; T Taniguchi; PJ Gebicke-Haerter; H Miki; T Takenawa; S Shimohama

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Jun. 2003, Peer-reviewed

  
• Essential role of the C-elegans Arp2/3 complex in cell migration during ventral enclosure

  M Sawa; S Suetsugu; A Sugimoto; H Miki; M Yamamoto; T Takenawa

  JOURNAL OF CELL SCIENCE, Apr. 2003, Peer-reviewed

  
• Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice

  C Klein; D Nguyen; CH Liu; A Mizoguchi; AK Bhan; H Miki; T Takenawa; FS Rosen; FW Alt; RC Mulligan; SB Snapper

  BLOOD, Mar. 2003, Peer-reviewed

  
• Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation

  P Sun; H Yamamoto; S Suetsugu; H Miki; T Takenawa; T Endo

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2003, Peer-reviewed

  
• Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth

  T Abe; M Kato; H Miki; T Takenawa; T Endo

  JOURNAL OF CELL SCIENCE, Jan. 2003, Peer-reviewed

  
• Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone

  M Nozumi; H Nakagawa; H Miki; T Takenawa; S Miyamoto

  JOURNAL OF CELL SCIENCE, Jan. 2003, Peer-reviewed

  
• Sustained activation of N-WASP through phosphorylation is essential for neurite extension

  S Suetsugu; M Hattori; H Miki; T Tezuka; T Yamamoto; K Mikoshiba; T Takenawa

  DEVELOPMENTAL CELL, Nov. 2002, Peer-reviewed

  
• Two verprolin homology domains increase the Arp2/3 complex-mediated actin polymerization activities of N-WASP and WAVE1 C-terminal regions

  H Yamaguchi; H Miki; T Takenawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2002, Peer-reviewed

  
• Reorganization of the actin cytoskeleton by WASP family proteins

  H Miki

  SEIKAGAKU, Sep. 2002, Peer-reviewed, Lead author, Last author, Corresponding author

  
• Neural Wiskott-Aldrich syndrome protein is involved in hepatocyte growth factor-induced migration, invasion, and tubulogenesis of epithelial cells

  H Yamaguchi; H Miki; T Takenawa

  CANCER RESEARCH, May 2002, Peer-reviewed

  
• Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading

  T Suzuki; H Mimuro; S Suetsugu; H Miki; T Takenawa; C Sasakawa

  CELLULAR MICROBIOLOGY, Apr. 2002, Peer-reviewed

  
• WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac

  H Miki; T Takenawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2002, Peer-reviewed, Lead author

  
• Spatial and temporal regulation of actin polymerization for cytoskeleton formation through Arp2/3 complex and WASP/WAVE proteins

  S Suetsugu; H Miki; T Takenawa

  CELL MOTILITY AND THE CYTOSKELETON, Mar. 2002, Peer-reviewed

  
• WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation

  M Kato; H Miki; S Kurita; T Endo; H Nakagawa; S Miyamoto; T Takenawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2002, Peer-reviewed

  
• Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts

  K Mizutani; H Miki; H He; H Maruta; T Takenawa

  CANCER RESEARCH, Feb. 2002, Peer-reviewed

  
• The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation

  S Vetterkind; H Miki; T Takenawa; Klawitz, I; KH Scheidtmann; U Preuss

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2002, Peer-reviewed

  
• Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2

  S Suetsugu; H Miki; H Yamaguchi; T Obinata; T Takenawa

  JOURNAL OF CELL SCIENCE, Dec. 2001, Peer-reviewed

  
• WASP and N-WASP in human platelets differ in sensitivity to protease calpain

  A Shcherbina; H Miki; DM Kenney; FS Rosen; T Takenawa; E Remold-O'Donnell

  BLOOD, Nov. 2001, Peer-reviewed

  
• Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP

  S Suetsugu; H Miki; T Takenawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2001, Peer-reviewed

  
• WIP regulates N-WASP-mediated actin polymerization and filopodium formation

  N Martinez-Quiles; R Rohatgi; IM Anton; M Medina; SP Saville; H Miki; H Yamaguchi; T Takenawa; JH Hartwig; RS Geha; N Ramesh

  NATURE CELL BIOLOGY, May 2001, Peer-reviewed

  
• WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement

  T Takenawa; H Miki

  JOURNAL OF CELL SCIENCE, May 2001, Peer-reviewed, Last author

  
• N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia

  H Nakagawa; H Miki; M Ito; K Ohashi; T Takenawa; S Miyamoto

  JOURNAL OF CELL SCIENCE, Apr. 2001, Peer-reviewed

  
• Requirement of the basic region of N-WASP/WAVE2 for actin-based motility

  S Suetsugu; H Miki; H Yamaguchi; T Takenawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2001, Peer-reviewed

  
• A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42

  M Fukuoka; S Suetsugu; H Miki; K Fukami; T Endo; T Takenawa

  JOURNAL OF CELL BIOLOGY, Feb. 2001, Peer-reviewed

  
• IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

  H Miki; H Yamaguchi; S Suetsugu; T Takenawa

  NATURE, Dec. 2000, Peer-reviewed, Lead author

  
• Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP

  H Yamaguchi; H Miki; S Suetsugu; L Ma; MW Kirschner; T Takenawa

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2000, Peer-reviewed

  
• Profilin enhances Cdc42-induced nucleation of actin polymerization

  Changsong Yang; Minzhou Huang; John DeBiasio; Martin Pring; Michael Joyce; Hiroaki Miki; Tadaomi Takenawa; Sally H. Zigmond

  Journal of Cell Biology, 04 Sep. 2000, Peer-reviewed

  
• Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri

  H Mimuro; T Suzuki; S Suetsugu; H Miki; T Takenawa; C Sasakawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2000, Peer-reviewed

  
• WASP-family, a critical signal transducer linking various signals to rapid actin-polymerization

  H Miki; T Takenawa

  SEIKAGAKU, Jul. 2000, Peer-reviewed

  
• Arp2/3 complex-independent actin regulatory function of WAVE

  N Sasaki; H Miki; T Takenawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2000, Peer-reviewed

  
• Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells

  T Suzuki; H Mimuro; H Miki; T Takenawa; T Sasaki; H Nakanishi; Y Takai; C Sasakawa

  JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 2000, Peer-reviewed

  
• Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells

  Y Banzai; H Miki; H Yamaguchi; T Takenawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2000, Peer-reviewed

  
• Distinct roles of profilin in cell morphological changes: microspikes, membrane ruffles, stress fibers, and cytokinesis

  S Suetsugu; H Miki; T Takenawa

  FEBS LETTERS, Sep. 1999, Peer-reviewed

  
• Wiskott-Aldrich syndrome protein induces actin clustering without direct binding to Cdc42

  M Kato; H Miki; K Imai; S Nonoyama; T Suzuki; C Sasakawa; T Takenawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1999, Peer-reviewed

  
• Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling

  H Miki; M Fukuda; E Nishida; T Takenawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1999, Peer-reviewed, Lead author

  
• The pleckstrin homology domain of the Wiskott-Aldrich syndrome protein is involved in the organization of actin cytoskeleton

  K Imai; S Nonoyama; H Miki; T Morio; K Fukami; QL Zhu; A Aruffo; HD Ochs; J Yata; T Takenawa

  CLINICAL IMMUNOLOGY, Aug. 1999, Peer-reviewed

  
• PH domains in WASP - a bug in the system? Reply

  H Miki; T Takenawa

  TRENDS IN CELL BIOLOGY, Jun. 1999, Peer-reviewed, Lead author

  
• Identification of two human WAVE SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex

  S Suetsugu; H Miki; T Takenawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 1999, Peer-reviewed

  
• The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

  R Rohatgi; L Ma; H Miki; M Lopez; T Kirchhausen; T Takenawa; MW Kirschner

  CELL, Apr. 1999, Peer-reviewed

  
• WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

  H Miki; S Suetsugu; T Takenawa

  EMBO JOURNAL, Dec. 1998, Peer-reviewed, Lead author

  
• The essential role of profilin in the assembly of actin for microspike formation

  S Suetsugu; H Miki; T Takenawa

  EMBO JOURNAL, Nov. 1998, Peer-reviewed

  
• Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri

  T Suzuki; H Miki; T Takenawa; C Sasakawa

  EMBO JOURNAL, May 1998, Peer-reviewed

  
• Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization

  H Miki; T Takenawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 1998, Peer-reviewed, Lead author

  
• Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

  H Miki; T Sasaki; Y Takai; T Takenawa

  NATURE, Jan. 1998, Peer-reviewed, Lead author

  
• Signaling through Grb2/Ash-control of the Ras pathway and cytoskeleton

  T Takenawa; H Miki; K Matuoka

  PROTEIN MODULES IN SIGNAL TRANSDUCTION, 1998, Peer-reviewed

  
• A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs

  K Matuoka; H Miki; K Takahashi; T Takenawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 1997, Peer-reviewed

  
• Identification of N-WASP homologs in human and rat brain

  M Fukuoka; H Miki; T Takenawa

  GENE, Sep. 1997, Peer-reviewed

  
• Tyrosine kinase signaling regulates Wiskott-Aldrich syndrome protein function, which is essential for megakaryocyte differentiation

  H Miki; S Nonoyama; QL Zhu; A Aruffo; HD Ochs; T Takenawa

  CELL GROWTH & DIFFERENTIATION, Feb. 1997, Peer-reviewed, Lead author

  
• beta-tubulin binds Src homology 2 domains through a region different from the tyrosine-phosphorylated protein-recognizing site

  T Itoh; K Miura; H Miki; T Takenawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1996, Peer-reviewed

  
• N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

  H Miki; K Miura; T Takenawa

  EMBO JOURNAL, Oct. 1996, Peer-reviewed, Lead author

  
• Interaction of Ash/Grb-2 via its SH3 domains with neuron-specific p150 and p65

  K Miura; H Miki; K Shimazaki; N Kawai; T Takenawa

  BIOCHEMICAL JOURNAL, Jun. 1996, Peer-reviewed

  
• Signal Transductions of SH2/SH3: Ash/Grb-2 Downstream Signaling

  Tadaomi Takenawa; Kenji Miura; Hiroaki Miki; Kazutada Watanabe

  Advances in Pharmacology, 1996, Peer-reviewed

  
• SPLICING ISOFORMS OF RAT ASH/GRB2 - ISOLATION AND CHARACTERIZATION OF THE CDNA AND GENOMIC DNA CLONES AND IMPLICATIONS FOR THE PHYSIOLOGICAL ROLES OF THE ISOFORMS

  K WATANABE; T FUKUCHI; H HOSOYA; T SHIRASAWA; K MATUOKA; H MIKI; T TAKENAWA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1995, Peer-reviewed

  
• ASSOCIATION OF ASH/GRB-2 WITH DYNAMIN THROUGH THE SRC HOMOLOGY-3 DOMAIN

  H MIKI; K MIURA; K MATUOKA; T NAKATA; N HIROKAWA; S ORITA; R KAIBUCHI; Y TAKAI; T TAKENAWA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1994, Peer-reviewed, Lead author

  
• KINETIC-PROPERTIES OF ASH/GRB2-INTERACTING GDP/GTP EXCHANGE PROTEIN

  H NAKANISHI; S ORITA; K KAIBUCHI; K MIURA; H MIKI; T TAKENAWA; Y TAKAI

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 1994, Peer-reviewed

  

External funds: Kakenhi

• Research on pH-dependent cell death program that occurs in the mitotic phase of cancer cells

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 50:Oncology and related fields

  Kyoto University;Osaka University

  Hiroaki Miki

  From 09 Jul. 2021, To 31 Mar. 2024, Project Closed

  細胞死

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19406/
• タンパク質のスルフォン酸化超硫黄による翻訳後修飾模倣とシグナル伝達

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University;Osaka University

  三木 裕明

  From 10 Sep. 2021, To 31 Mar. 2026, Granted

  シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05272/
• Management of international relation and facility for promotion of research on sulfur biology

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Tohoku University

  本橋 ほづみ

  From 10 Sep. 2021, To 31 Mar. 2026, Granted

  硫黄代謝;超硫黄分子;国際交流;技術支援;ストレス応答;イメージング;ケミカルプローブ;ミトコンドリア;プロテオスタシス;遺伝子改変マウス;支援;硫黄生物学研究;月例領域プログレス;分析技術;計測技術;研究資源共有化

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-21H05258/
• Analysis of cellular response to acidification of tumor microenvironments

  Grant-in-Aid for Scientific Research (B)

  Basic Section 50010:Tumor biology-related

  Kyoto University;Osaka University

  Hiroaki Miki

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  がん;リソソーム;酸性環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03515/
• Regulation of lysosome function in cellular adaptation to acidic environment

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Hiroaki Miki

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  酸性環境適応;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04041/
• Functional regulation of proteins by Cys phosphorylation

  Grant-in-Aid for Challenging Exploratory Research

  Osaka University

  Hiroaki Miki

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  蛋白質;シグナル伝達;ストレス;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14723/
• Molecular mechanism regulating intracellular and organismal magnesium levels

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Hiroaki MIKI

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  マグネシウム;ストレス;癌;循環器・高血圧

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26291042/
• 大腸がん悪性化における上皮管腔組織秩序の破綻

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Osaka University

  三木 裕明

  From 01 Apr. 2014, To 31 Mar. 2015, Discontinued

  癌;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26112711/
• Signal transduction by redox sensor molecules

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Osaka University

  Hiroaki Miki

  From 10 Jul. 2014, To 31 Mar. 2019, Project Closed

  シグナル伝達;ストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-26111007/
• Oxygen biology: a new criterion for integrated understanding of life

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Yasuo Mori

  From 10 Jul. 2014, To 31 Mar. 2019, Project Closed

  酸素;活性酸素種;細胞シグナル;イメージング;酸素生物学;低酸素;生体イメージング;ハイポキシア

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-26111001/
• 細胞極性制御におけるリン脂質PIP3輸送の役割

  Grant-in-Aid for Young Scientists (S)

  Osaka University

  三木 裕明

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  GAKIN;Par1;PIP3;Parl

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20677002/
• タンパク質の酸化還元修飾による細胞機能制御

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  三木 裕明

  From 01 Apr. 2008, To 31 Mar. 2009, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20370080/
• Redox signaling and cancer formation

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University

  Hiroaki MIKI

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  Wnt;Dishevelled (Dvl);nucleoredoxin (NRX);がん;Nucleoredoxin (NRX);Dishevelled(Dvl);Nucleoredoxin(NRX)

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20013025/
• レドックス制御と細胞がん化の情報伝達

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University;The University of Tokyo

  三木 裕明

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  Wnt;Dishevelled(Dvl);Nucleoredoxin(NRX);がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18013010/
• アダプター蛋白IRSp53と巨大蛋白複合体による細胞機能制御

  Grant-in-Aid for Young Scientists (A)

  Osaka University;The University of Tokyo

  三木 裕明

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  Rhoファミリー;IRSp53;Eps8;SF3a66;チロシンリン酸化;神経突起;Ips8;Rac

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17687019/
• レドックス制御と細胞がん化の情報伝達

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  三木 裕明

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  Wnt;Dsihevelled(Dvl);Nucleoredoxin(NRX);がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17014021/
• レドックス制御と細胞がん化の情報伝達

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  三木 裕明

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  Wnt;Dishevelled;beta-catenin;レドックス制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16022217/
• 微小管安定性制御の情報伝達と細胞癌化

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  三木 裕明

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  Wnt;Dishevelled;微小管;β-catenin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15024216/
• ラッフル膜形成に関わるWAVEの機能制御機構の解析

  Grant-in-Aid for Young Scientists (B)

  The University of Tokyo

  三木 裕明

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  WAVE;IRSp53;Eps8;Rac;SF3a複合体;質量分析;WASP;Arp2;3複合体;N1E-115

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13780568/
• Dynamic reorganization of cytoskeletion by WASP family proteins

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  Tadaomi TAKENAWA

  From 01 Apr. 2000, To 31 Mar. 2003, Project Closed

  アクチン;細胞運動;WASP;WAVE;細胞骨格;神経突起;N-WASP;チロシンキナーゼ;ユビキチン化, actin;cell movement;WASP;WAVE;cytoskeleton

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12307003/
• Signaltransduction of cytoskeleton and cell movement

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  Tadaomi TAKENAWA

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  アクチン線維;浸潤;転移;WAVE;B16細胞;葉状仮足;癌細胞;細胞運動;アクチン;WASP;糸状突起;葉状突起;系状突起, Actin cytoskeleton;Invasion;Metastasis;WAVE;B16 cells;lamellipodia

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12219202/
• WASPファミリー蛋白によるアクチン細胞骨格制御機構の解明

  Grant-in-Aid for Encouragement of Young Scientists (A)

  The University of Tokyo

  三木 裕明

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  N-WASP;Cdc42;Arp2;3 complex;糸状仮足;神経発生;WAVE;Rac;IRSp53;WASP;アクチン;3;PIP2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11780507/
• リン脂質代謝関連蛋白及びSH2/SH3領域による細胞増殖制御

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  The University of Tokyo

  竹縄 忠臣

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  アクチン;N-WASP;Arp2;3;細胞運動;膜ラッフリング;プロフィリン;Rac;WAVE;フィロポジア;Cdc42;チロシンキナーゼ;Ash;Grb-2;SH_2;SH_3;Ras;SH2;SH3

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06283202/
• がん細胞の酸性環境適応におけるリソソーム膜動態調節の研究

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 50:Oncology and related fields

  Kyoto University

  三木 裕明

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00409/
• Global Exploration for Redox Supermolecules Evolving in Life Functions

  Fund for the Promotion of Joint International Research (International Leading Research )

  Biological Sciences

  Tohoku University

  赤池 孝章

  From 17 Nov. 2023, To 31 Mar. 2030, Granted

  レドックス超分子;超硫黄分子;酸化ストレス;レドックス超分子生命科学;Redox Supermolecules;Global Exploration;Sulfur Biochemistry;Sulfur Biotechnology;Sulfur Medicine

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K20040/
• Exploring supersulfide that mediates energy metabolism and redox signaling

  Grant-in-Aid for Scientific Research (S)

  Broad Section H

  Tohoku University

  赤池 孝章

  From 01 Apr. 2024, To 31 Mar. 2029, Granted

  超硫黄分子;超硫黄カテネーション;エネルギー代謝;過酸化脂質ラジカル;酸化ストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24H00063/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Biochemistry I (Advanced Chemistry)

  7416, Spring, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Chemical Basis of Life

  7107, Spring, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Biochemistry II

  7064, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Chemical Science and Technology

  7501, Spring, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Master's Thesis

  W698, Year-long, Graduate School of Engineering, 0
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Biorecognics

  H815, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Frontiers in the Field of Chemical Biology and Biological Chemistry

  H409, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Biochemistry II

  7064, Fall, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Biochemistry I (Advanced Chemistry)

  7416, Spring, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Bio-Medical Engineering C

  W689, Spring, Graduate School of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Master's Thesis

  D899, Year-long, Graduate School of Engineering, 0
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Biochemistry II

  7064, Fall, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Biochemistry I (Advanced Chemistry)

  7416, Spring, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Master's Thesis

  D899, Year-long, Graduate School of Engineering, 0
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Biorecognics

  H815, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Frontiers in the Field of Chemical Biology and Biological Chemistry

  H409, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3

Participation in PhD Defense

• Development of N-acyl-N-aryl sulfonamide warheads for covalent protein modification and inhibition

  KAWANO MASAHARU, Graduate School of Engineering, Sub-chief Examiner

  24 Mar. 2025