Basic Information

Professional Memberships

• 日本心臓病学会
• 日本循環器病学会
• 日本内科学会

Academic Degree

• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  200901046990029464

researchmap URL

• https://researchmap.jp/read0201552

Research

Papers

• The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy

  Chinatsu Yamada; Koichiro Kuwahara; Masatoshi Yamazaki; Yasuaki Nakagawa; Toshio Nishikimi; Hideyuki Kinoshita; Yoshihiro Kuwabara; Takeya Minami; Yuko Yamada; Junko Shibata; Kazuhiro Nakao; Kosai Cho; Yuji Arai; Haruo Honjo; Kaichiro Kamiya; Kazuwa Nakao; Takeshi Kimura

  CARDIOVASCULAR RESEARCH, Jan. 2016, Peer-reviewed

  
• Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites

  Toshio Nishikimi; Yasuaki Nakagawa; Naoto Minamino; Masashi Ikeda; Kyoko Tabei; Aoi Fujishima; Kentaro Takayama; Kazumi Akimoto; Chinatsu Yamada; Kazuhiro Nakao; Takeya Minami; Yoshihiro Kuwabara; Hideyuki Kinoshita; Takayoshi Tsutamoto; Toshihiko Ishimitsu; Kenji Kangawa; Koichiro Kuwahara; Kazuwa Nakao

  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Sep. 2015, Peer-reviewed

  
• Living-donor lobar lung transplantation provides similar survival to cadaveric lung transplantation even for very ill patients

  Hiroshi Date; Masaaki Sato; Akihiro Aoyama; Tetsu Yamada; Toshiyuki Mizota; Hideyuki Kinoshita; Tomohiro Handa; Kiminobu Tanizawa; Kazuo Chin; Kenji Minakata; Fengshi Chen

  EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Jun. 2015, Peer-reviewed

  
• Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model

  Miwa Tanaka; Shuichi Yamaguchi; Yukari Yamazaki; Hideyuki Kinoshita; Koichiro Kuwahara; Kazuwa Nakao; Patrick Y. Jay; Tetsuo Noda; Takuro Nakamura

  SCIENTIFIC REPORTS, Jan. 2015, Peer-reviewed

  
• Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure

  Yuko Yamada; Hideyuki Kinoshita; Koichiro Kuwahara; Yasuaki Nakagawa; Yoshihiro Kuwabara; Takeya Minami; Chinatsu Yamada; Junko Shibata; Kazuhiro Nakao; Kosai Cho; Yuji Arai; Shinji Yasuno; Toshio Nishikimi; Kenji Ueshima; Shiro Kamakura; Motohiro Nishida; Shigeki Kiyonaka; Yasuo Mori; Takeshi Kimura; Kenji Kangawa; Kazuwa Nakao

  CARDIOVASCULAR RESEARCH, Oct. 2014, Peer-reviewed

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• The Effects of Super-Flux (High Performance) Dialyzer on Plasma Glycosylated Pro-B-Type Natriuretic Peptide (proBNP) and Glycosylated N-Terminal proBNP in End-Stage Renal Disease Patients on Dialysis

  Yasuaki Nakagawa; Toshio Nishikimi; Koichiro Kuwahara; Shinji Yasuno; Hideyuki Kinoshita; Yoshihiro Kuwabara; Kazuhiro Nakao; Takeya Minami; Chinatsu Yamada; Kenji Ueshima; Yoshihiro Ikeda; Hiroyuki Okamoto; Kazukiyo Horii; Kiyoshi Nagata; Kenji Kangawa; Naoto Minamino; Kazuwa Nakao

  PLOS ONE, Mar. 2014, Peer-reviewed

  
• Management of borderline pulmonary arterial hypertension associated with connective tissue diseases

  Hajime Yoshifuji; Hideyuki Kinoshita

  Japanese Journal of Clinical Immunology, 2014, Peer-reviewed

  
• Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy

  Shinji Yasuno; Koichiro Kuwahara; Hideyuki Kinoshita; Chinatsu Yamada; Yasuaki Nakagawa; Satoru Usami; Yoshihiro Kuwabara; Kenji Ueshima; Masaki Harada; Toshio Nishikimi; Kazuwa Nakao

  BRITISH JOURNAL OF PHARMACOLOGY, Dec. 2013, Peer-reviewed

  
• Adrenal reserve function after unilateral adrenalectomy in patients with primary aldosteronism

  Kyoko Honda; Masakatsu Sone; Naohisa Tamura; Takuhiro Sonoyama; Daisuke Taura; Katsutoshi Kojima; Yorihide Fukuda; Shiro Tanaka; Shinji Yasuno; Toshihito Fujii; Hideyuki Kinoshita; Hiroyuki Ariyasu; Naotetsu Kanamoto; Masako Miura; Akihiro Yasoda; Hiroshi Arai; Kenji Ueshima; Kazuwa Nakao

  JOURNAL OF HYPERTENSION, Oct. 2013, Peer-reviewed

  
• Association of Takayasu arteritis with HLA-B(star)67:01 and two amino acids in HLA-B protein

  Chikashi Terao; Hajime Yoshifuji; Koichiro Ohmura; Kosaku Murakami; Daisuke Kawabata; Kimiko Yurugi; Junichi Tazaki; Hideyuki Kinoshita; Akinori Kimura; Masashi Akizuki; Yasushi Kawaguchi; Hisashi Yamanaka; Yasuo Miura; Taira Maekawa; Hiroo Saji; Tsuneyo Mimori; Fumihiko Matsuda

  RHEUMATOLOGY, Oct. 2013, Peer-reviewed

  
• Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population

  Chikashi Terao; Hajime Yoshifuji; Akinori Kimura; Takayoshi Matsumura; Koichiro Ohmura; Meiko Takahashi; Masakazu Shimizu; Takahisa Kawaguchi; Zhiyong Chen; Taeko K. Naruse; Aiko Sato-Otsubo; Yusuke Ebana; Yasuhiro Maejima; Hideyuki Kinoshita; Kosaku Murakami; Daisuke Kawabata; Yoko Wada; Ichiei Narita; Junichi Tazaki; Yasushi Kawaguchi; Hisashi Yamanaka; Kimiko Yurugi; Yasuo Miura; Taira Maekawa; Seishi Ogawa; Issei Komuro; Ryozo Nagai; Ryo Yamada; Yasuharu Tabara; Mitsuaki Isobe; Tsuneyo Mimori; Fumihiko Matsuda

  AMERICAN JOURNAL OF HUMAN GENETICS, Aug. 2013, Peer-reviewed

  
• Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16

  Emi Matsumoto; Sayaka Sasaki; Hideyuki Kinoshita; Takuya Kito; Hiroya Ohta; Morichika Konishi; Koichiro Kuwahara; Kazuwa Nakao; Nobuyuki Itoh

  GENES TO CELLS, Jul. 2013, Peer-reviewed

  
• Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts

  Yoshihiro Kuwabara; Koichiro Kuwahara; Makoto Takano; Hideyuki Kinoshita; Yuji Arai; Shinji Yasuno; Yasuaki Nakagawa; Sachiyo Igata; Satoru Usami; Takeya Minami; Yuko Yamada; Kazuhiro Nakao; Chinatsu Yamada; Junko Shibata; Toshio Nishikimi; Kenji Ueshima; Kazuwa Nakao

  JOURNAL OF THE AMERICAN HEART ASSOCIATION, Jun. 2013, Peer-reviewed

  
• Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure

  Toshio Nishikimi; Hiroyuki Okamoto; Masahiro Nakamura; Naoko Ogawa; Kazukiyo Horii; Kiyoshi Nagata; Yasuaki Nakagawa; Hideyuki Kinoshita; Chinatsu Yamada; Kazuhiro Nakao; Takeya Minami; Yoshihiro Kuwabara; Koichiro Kuwahara; Izuru Masuda; Kenji Kangawa; Naoto Minamino; Kazuwa Nakao

  PLOS ONE, Jan. 2013, Peer-reviewed

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• Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice

  Takeya Minami; Koichiro Kuwahara; Yasuaki Nakagawa; Minoru Takaoka; Hideyuki Kinoshita; Kazuhiro Nakao; Yoshihiro Kuwabara; Yuko Yamada; Chinatsu Yamada; Junko Shibata; Satoru Usami; Shinji Yasuno; Toshio Nishikimi; Kenji Ueshima; Masataka Sata; Hiroyasu Nakano; Takahiro Seno; Yutaka Kawahito; Kenji Sobue; Akinori Kimura; Ryozo Nagai; Kazuwa Nakao

  EMBO JOURNAL, Nov. 2012, Peer-reviewed

  
• In vivo Site-Specific Transfection of Naked Plasmid DNA and siRNAs in Mice by Using a Tissue Suction Device

  Kazunori Shimizu; Shigeru Kawakami; Kouji Hayashi; Hideyuki Kinoshita; Koichiro Kuwahara; Kazuwa Nakao; Mitsuru Hashida; Satoshi Konishi

  PLOS ONE, Jul. 2012, Peer-reviewed

  
• The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure

  Toshio Nishikimi; Masashi Ikeda; Yosuke Takeda; Toshihiko Ishimitsu; Ikuko Shibasaki; Hirotsugu Fukuda; Hideyuki Kinoshita; Yasuaki Nakagawa; Koichiro Kuwahara; Kazuwa Nakao

  HEART, Jan. 2012, Peer-reviewed

  
• Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes

  Leo Hata; Masao Murakami; Koichiro Kuwahara; Yasuaki Nakagawa; Hideyuki Kinoshita; Satoru Usami; Shinji Yasuno; Masataka Fujiwara; Yoshihiro Kuwabara; Takeya Minami; Yuko Yamada; Chinatsu Yamada; Kazuhiro Nakao; Kenji Ueshima; Toshio Nishikimi; Kazuwa Nakao

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Jun. 2011, Peer-reviewed

  
• Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression

  Koichiro Kuwahara; Hideyuki Kinoshita; Yoshihiro Kuwabara; Yasuaki Nakagawa; Satoru Usami; Takeya Minami; Yuko Yamada; Masataka Fujiwara; Kazuwa Nakao

  MOLECULAR AND CELLULAR BIOLOGY, Sep. 2010, Peer-reviewed

  
• Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

  Eric M. Small; Jeffrey E. Thatcher; Lillian B. Sutherland; Hideyuki Kinoshita; Robert D. Gerard; James A. Richardson; J. Michael DiMaio; Hesham Sadek; Koichiro Kuwahara; Eric N. Olson

  CIRCULATION RESEARCH, Jul. 2010, Peer-reviewed

  
• Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart

  Hideyuki Kinoshita; Koichiro Kuwahara; Motohiro Nishida; Zhong Jian; Xianglu Rong; Shigeki Kiyonaka; Yoshihiro Kuwabara; Hitoshi Kurose; Ryuji Inoue; Yasuo Mori; Yuhao Li; Yasuaki Nakagawa; Satoru Usami; Masataka Fujiwara; Yuko Yamada; Takeya Minami; Kenji Ueshima; Kazuwa Nakao

  CIRCULATION RESEARCH, Jun. 2010, Peer-reviewed

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• p300 Plays a Critical Role in Maintaining Cardiac Mitochondrial Function and Cell Survival in Postnatal Hearts

  Yasuaki Nakagawa; Koichiro Kuwahara; Genzo Takemura; Masaharu Akao; Masashi Kato; Yuji Arai; Makoto Takano; Masaki Harada; Masao Murakami; Michio Nakanishi; Satoru Usami; Shinji Yasuno; Hideyuki Kinoshita; Masataka Fujiwara; Kenji Ueshima; Kazuwa Nakao

  CIRCULATION RESEARCH, Oct. 2009, Peer-reviewed

  
• T-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice With Heart Failure

  Hideyuki Kinoshita; Koichiro Kuwahara; Makoto Takano; Yuji Arai; Yoshihiro Kuwabara; Shinji Yasuno; Yasuaki Nakagawa; Michio Nakanishi; Masaki Harada; Masataka Fujiwara; Masao Murakami; Kenji Ueshima; Kazuwa Nakao

  CIRCULATION, Sep. 2009, Peer-reviewed

  
• Guanylyl Cyclase-A Inhibits Angiotensin II Type 2 Receptor-Mediated Pro-Hypertrophic Signaling in the Heart

  Yuhao Li; Yoshihiko Saito; Koichiro Kuwahara; Xianglu Rong; Ichiro Kishimoto; Masaki Harada; Yuichiro Adachi; Michio Nakanishi; Hideyuki Kinoshita; Masatsugu Horiuchi; Michael Murray; Kazuwa Nakao

  ENDOCRINOLOGY, Aug. 2009, Peer-reviewed

  
• Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death

  Shinji Yasuno; Satoru Usami; Koichiro Kuwahara; Michio Nakanishi; Yuji Arai; Hideyuki Kinoshita; Yasuaki Nakagawa; Masataka Fujiwara; Masao Murakami; Kenji Ueshima; Masaki Harada; Kazuwa Nakao

  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Jun. 2009, Peer-reviewed

  
• Fgf16 Is Required for Cardiomyocyte Proliferation in the Mouse Embryonic Heart

  Yuhei Hotta; Sayaka Sasaki; Morichika Konishi; Hideyuki Kinoshita; Koichiro Kuwahara; Kazuwa Nakao; Nobuyuki Itoh

  DEVELOPMENTAL DYNAMICS, Oct. 2008, Peer-reviewed

  
• Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation.

  Nakanishi M; Harada M; Kishimoto I; Kuwahara K; Kawakami R; Nakagawa Y; Yasuno S; Usami S; Kinoshita H; Adachi Y; Fukamizu A; Saito Y; Nakao K

  Circulation journal : official journal of the Japanese Circulation Society, Aug. 2007, Peer-reviewed

  
• Images in cardiovascular medicine. Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance.

  Nakanishi M; Harada M; Tadamura E; Kotani H; Kawakami R; Kuwahara K; Nakagawa Y; Usami S; Kinoshita H; Fujiwara M; Hosoda K; Ueshima K; Nakao K

  Circulation, Jul. 2007, Peer-reviewed

  
• Enhanced cardiac production of matrix metalloproteinase-2 and-9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction

  Satoshi Yasuda; Shunichi Miyazaki; Hideyuki Kinoshita; Noritoshi Nagaya; Munetake Kanda; Yoichi Goto; Hiroshi Nonogi

  CLINICAL SCIENCE, Jan. 2007, Peer-reviewed

  
• Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes

  Yasuaki Nakagawa; Koichiro Kuwahara; Masaki Harada; Nobuki Takahashi; Shinji Yasuno; Yuichiro Adachi; Rika Kawakami; Michio Nakanishi; Keiji Tanimoto; Satoru Usami; Hideyuki Kinoshita; Yoshihiko Saito; Kazuwa Nakao

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Dec. 2006, Peer-reviewed

  
• Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction

  R Kawakami; Y Saito; Kishimoto, I; M Harada; K Kuwahara; N Takahashi; Y Nakagawa; M Nakanishi; K Tanimoto; S Usami; S Yasuno; H Kinoshita; H Chusho; N Tamura; Y Ogawa; K Nakao

  CIRCULATION, Nov. 2004, Peer-reviewed

  
• NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function

  K Kuwahara; Y Saito; M Takano; Y Arai; S Yasuno; Y Nakagawa; N Takahashi; Y Adachi; G Takemura; M Horie; Y Miyamoto; T Morisaki; S Kuratomi; A Noma; H Fujiwara; Y Yoshimasa; H Kinoshita; R Kawakami; Kishimoto, I; M Nakanishi; S Usami; Y Saito; M Harada; K Nakao

  EMBO JOURNAL, Dec. 2003, Peer-reviewed