Basic Information

Academic Degree

• 理学(Yokohama City University)
• 医科学(Kyoto University)

Language of Instruction

• Japanese

ID,URL

• ORCID ID

  0000-0002-5601-9777

• J-Global ID

  201901012759819288

• Researcher number

  50769833

researchmap URL

• https://researchmap.jp/nakamurasou

Research

Research Topics, Overview of the research

• Research Topics

  Establishment of production method of iPS cell derived platelet preparation

• Overview of the research

  Our goal is to establish the production of iPS cell-derived platelet preparations to the industrialization level and to contribute to creating a future in which all people in the world can safely transfuse.
  I am researching the following contents.
  Establishment of protocol for establishing megakaryocyte cell line from various iPS cells.
  Establishment of industrial culture method to enhance platelet production.
  improvement of platelet concentration process, platelet washing, Platelet separation
  

Research Areas

• Life sciences, Biomedical engineering

Papers

• Osteogenic effects and safety of human induced pluripotent stem cell-derived megakaryocytes and platelets produced on a clinical scale.

  Takahito Arai; Yasuhiro Shiga; Michiaki Mukai; Naoya Takayama; Susumu Tashiro; Ikuko Tajiri; Kentaro Kosaka; Masashi Sato; Sou Nakamura; Haruki Okamoto; Seiji Kimura; Kazuhide Inage; Miyako Suzuki-Narita; Yawara Eguchi; Sumihisa Orita; Koji Eto; Seiji Ohtori

  Regenerative therapy, Jun. 2024

  
• Defective flow space limits the scaling up of turbulence bioreactors for platelet generation

  Haruki Okamoto; Kosuke Fujio; Sou Nakamura; Yasuo Harada; Hideki Hayashi; Natsumi Higashi; Atsushi Ninomiya; Ryota Tanaka; Naoshi Sugimoto; Naoya Takayama; Atsushi Kaneda; Akira Sawaguchi; Yoshikazu Kato; Koji Eto

  Communications Engineering, 17 Jun. 2024

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• iPSC-Derived Mesenchymal Stem Cells Supports the Ex Vivo expansion of Human Hematopoietic Stem and Progenitor Cells Via Sterile Inflammation Pathway

  Maria Alejandra Kanashiro; Sudip Kumar Paul; Masamitsu Sone; Ikuyo Yoshino; Kyoko Tsujimura; Makoto Ikeya; Sou Nakamura; Koji Eto; Naoya Takayama

  Blood, 02 Nov. 2023

  
• A bioreactor utilizing high-resolution three dimensional microchannel for on-chip platelet production

  Hiroki Kumon; Shinya Sakuma; Yusuke Kasai; Sou Nakamura; Koji Eto; Fumihito Arai

  MHS 2018 - 2018 29th International Symposium on Micro-NanoMechatronics and Human Science, 01 Dec. 2018

  
• A design strategy of a bioreactor for platelet production using fluid force

  Hiroki Kumon; Shinya Sakuma; Sou Nakamura; Koji Eto; Fumihito Arai

  MHS 2017 - 28th 2017 International Symposium on Micro-NanoMechatronics and Human Science, 28 Feb. 2018

  
• ゲノム編集技術を用いたiPS細胞由来特異的HPA発現パネル細胞株の開発 HPA-3a抗体の特異的な検出

  林 智也; 三島 優一; 中村 壮; 杉本 直志; 堀田 秋津; 正木 美香子; 田中 光信; 石井 博之; 立山 英美; 藤村 吉博; 平山 文也; 谷 慶彦; 木村 貴文; 江藤 浩之; 瀧原 義宏

  日本輸血細胞治療学会誌, Apr. 2023

  
• A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility

  Si Jing Chen; Kazuya Hashimoto; Kosuke Fujio; Karin Hayashi; Sudip Kumar Paul; Akinori Yuzuriha; Wei-Yin Qiu; Emiri Nakamura; Maria Alejandra Kanashiro; Mio Kabata; Sou Nakamura; Naoshi Sugimoto; Atsushi Kaneda; Takuya Yamamoto; Hirohide Saito; Naoya Takayama; Koji Eto

  Nature Communications, 22 Mar. 2024

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• Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells.

  Charlotte Flahou; Tatsuya Morishima; Natsumi Higashi; Yoshikazu Hayashi; Huaigeng Xu; Bo Wang; Chaoqi Zhang; Atsushi Ninomiya; Wei-Yin Qiu; Akinori Yuzuriha; Daisuke Suzuki; Sou Nakamura; Markus Manz; Shin Kaneko; Akitsu Hotta; Hitoshi Takizawa; Koji Eto; Naoshi Sugimoto

  Biochemical and biophysical research communications, 20 Apr. 2023

  
• Modeling Congenital Amegakaryocytic Thrombocytopenia Using Patient-Specific Induced Pluripotent Stem Cells

  Naoya Takayama; Shinji Hirata; Ryoko Jono-Ohnishi; Sou Nakamura; Sho-ichi Hirose; Hiroshi Endo; Masanori Nishi; Yuhei Hamazaki; Shin Kaneko; Eiichi Ishii; Hiromitsu Nakauchi; Shinji Kunishima; Koji Eto

  BLOOD, Nov. 2011, Peer-reviewed

  
• Production and nonclinical evaluation of an autologous iPSC-derived platelet product for the iPLAT1 clinical trial.

  Naoshi Sugimoto; Sou Nakamura; Shin Shimizu; Akiko Shigemasa; Junya Kanda; Nobuki Matsuyama; Mitsunobu Tanaka; Tomoya Hayashi; Akihiro Fuchizaki; Masayuki Nogawa; Naohide Watanabe; Shinichiro Okamoto; Makoto Handa; Akira Sawaguchi; Dai Momose; Ki-Ryang Koh; Yoshihiko Tani; Akifumi Takaori-Kondo; Koji Eto

  Blood advances, 23 Sep. 2022

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• iPLAT1: The first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study.

  Naoshi Sugimoto; Junya Kanda; Sou Nakamura; Toshiyuki Kitano; Masakatsu Hishizawa; Tadakazu Kondo; Shin Shimizu; Akiko Shigemasa; Hideyo Hirai; Yasuyuki Arai; Manabu Minami; Harue Tada; Dai Momose; Ki-Ryang Koh; Masayuki Nogawa; Naohide Watanabe; Shinichiro Okamoto; Makoto Handa; Akira Sawaguchi; Nobuki Matsuyama; Mitsunobu Tanaka; Tomoya Hayashi; Akihiro Fuchizaki; Yoshihiko Tani; Akifumi Takaori-Kondo; Koji Eto

  Blood, 16 Sep. 2022

  
• Three-dimensional microchannel reflecting cell size distribution for on-chip production of platelet-like particles

  Shinya Sakuma; Hiroki Kumon; Sou Nakamura; Yusuke Kasai; Koji Eto; Fumihito Arai

  Microfluidics and Nanofluidics, Apr. 2021

  
• Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells

  N. Takayama; S. Nishimura; S. Nakamura; T. Shimizu; R. Ohnishi; H. Endo; T. Yamaguchi; M. Otsu; K. Nishimura; M. Nakanishi; A. Sawaguchi; R. Nagai; K. Takahashi; S. Yamanaka; H. Nakauchi; K. Eto

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Jul. 2011, Peer-reviewed

  
• A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells.

  Izuru Mizoguchi; Yasuhiro Katahira; Shinya Inoue; Eri Sakamoto; Aruma Watanabe; Yuma Furusaka; Atsushi Irie; Satoru Senju; Yasuharu Nishimura; Shusaku Mizukami; Kenji Hirayama; Sou Nakamura; Koji Eto; Hideaki Hasegawa; Takayuki Yoshimoto

  ALTEX, 24 Feb. 2022

  
• Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs.

  Masamitsu Sone; Sou Nakamura; Sachiko Umeda; Harumi Ginya; Motohiko Oshima; Maria Alejandra Kanashiro; Sudip Kumar Paul; Kanae Hashimoto; Emiri Nakamura; Yasuo Harada; Kyoko Tsujimura; Atsunori Saraya; Tomoyuki Yamaguchi; Naoshi Sugimoto; Akira Sawaguchi; Atsushi Iwama; Koji Eto; Naoya Takayama

  Stem cell reports, 14 Dec. 2021

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• Microfluidic Bioreactor Made of Cyclo-Olefin Polymer for Observing On-Chip Platelet Production.

  Hiroki Kumon; Shinya Sakuma; Sou Nakamura; Hisataka Maruyama; Koji Eto; Fumihito Arai

  Micromachines, 15 Oct. 2021

  
• Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis.

  Akinori Yuzuriha; Sou Nakamura; Naoshi Sugimoto; Shunsuke Kihara; Masato Nakagawa; Takuya Yamamoto; Kiyotoshi Sekiguchi; Koji Eto

  Stem cell research, May 2021

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• Development of platelet replacement therapy using human induced pluripotent stem cells.

  Sou Nakamura; Naoshi Sugimoto; Koji Eto

  Development, growth & differentiation, Feb. 2021

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• Ex vivo generation of platelet products from human iPS cells.

  Sou Nakamura; Naoshi Sugimoto; Koji Eto

  Inflammation and regeneration, 01 Dec. 2020

  
• Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells.

  Koji Takaishi; Masahiro Takeuchi; Shokichi Tsukamoto; Naoya Takayama; Motohiko Oshima; Kenji Kimura; Yusuke Isshiki; Kensuke Kayamori; Yutaro Hino; Nagisa Oshima-Hasegawa; Shio Mitsukawa; Yusuke Takeda; Naoya Mimura; Chikako Ohwada; Tohru Iseki; Sou Nakamura; Koji Eto; Atsushi Iwama; Koutaro Yokote; Chiaki Nakaseko; Emiko Sakaida

  Haematologica, May 2020

  
• iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity.

  Daisuke Suzuki; Charlotte Flahou; Norihide Yoshikawa; Ieva Stirblyte; Yoshikazu Hayashi; Akira Sawaguchi; Marina Akasaka; Sou Nakamura; Natsumi Higashi; Huaigeng Xu; Takuya Matsumoto; Kosuke Fujio; Markus G Manz; Akitsu Hotta; Hitoshi Takizawa; Koji Eto; Naoshi Sugimoto

  Stem cell reports, 14 Jan. 2020

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• [Novel physico-chemical regulation mechanism enables the production of 100 billion platelets].

  Sou Nakamura; Koji Eto

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2020

  
• De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.

  Tsutomu Toki; Kenichi Yoshida; RuNan Wang; Sou Nakamura; Takanobu Maekawa; Kumiko Goi; Megumi C Katoh; Seiya Mizuno; Fumihiro Sugiyama; Rika Kanezaki; Tamayo Uechi; Yukari Nakajima; Yusuke Sato; Yusuke Okuno; Aiko Sato-Otsubo; Yusuke Shiozawa; Keisuke Kataoka; Yuichi Shiraishi; Masashi Sanada; Kenichi Chiba; Hiroko Tanaka; Kiminori Terui; Tomohiko Sato; Takuya Kamio; Hirotoshi Sakaguchi; Shouichi Ohga; Madoka Kuramitsu; Isao Hamaguchi; Akira Ohara; Hitoshi Kanno; Satoru Miyano; Seiji Kojima; Akira Ishiguro; Kanji Sugita; Naoya Kenmochi; Satoru Takahashi; Koji Eto; Seishi Ogawa; Etsuro Ito

  American journal of human genetics, 06 Sep. 2018

  
• Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.

  Yukitaka Ito; Sou Nakamura; Naoshi Sugimoto; Tomohiro Shigemori; Yoshikazu Kato; Mikiko Ohno; Shinya Sakuma; Keitaro Ito; Hiroki Kumon; Hidenori Hirose; Haruki Okamoto; Masayuki Nogawa; Mio Iwasaki; Shunsuke Kihara; Kosuke Fujio; Takuya Matsumoto; Natsumi Higashi; Kazuya Hashimoto; Akira Sawaguchi; Ken-Ichi Harimoto; Masato Nakagawa; Takuya Yamamoto; Makoto Handa; Naohide Watanabe; Eiichiro Nishi; Fumihito Arai; Satoshi Nishimura; Koji Eto

  Cell, 26 Jul. 2018

  
• Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations.

  Hiraku Takei; Yoko Edahiro; Shuichi Mano; Nami Masubuchi; Yoshihisa Mizukami; Misa Imai; Soji Morishita; Kyohei Misawa; Tomonori Ochiai; Satoshi Tsuneda; Hiroshi Endo; Sou Nakamura; Koji Eto; Akimichi Ohsaka; Marito Araki; Norio Komatsu

  British journal of haematology, Jun. 2018

  
• Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets.

  Shinji Hirata; Takahiko Murata; Daisuke Suzuki; Sou Nakamura; Ryoko Jono-Ohnishi; Hidenori Hirose; Akira Sawaguchi; Satoshi Nishimura; Naoshi Sugimoto; Koji Eto

  Stem cells translational medicine, Mar. 2017

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• Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells.

  Ayako Aihara; Tomo Koike; Natsuki Abe; Sou Nakamura; Akira Sawaguchi; Takanori Nakamura; Naoshi Sugimoto; Hiromitsu Nakauchi; Taito Nishino; Koji Eto

  Blood advances, 28 Feb. 2017

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• A design strategy of a bioreactor for platelet generation

  KUMON Hiroki; SAKUMA Shinya; ITO Keitaro; NAKAMURA Sou; ETO Koji; FUKUDA Toshio; ARAI Fumihito

  The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec), 2017

  
• Natural Killer Cell Activities Against iPSCs-Derived HLA-Knockout Platelets and Megakaryocytes Reveal Perfect Rejection Profiles for Allotransfusion

  Daisuke Suzuki; Naoshi Sugimoto; Norihide Yoshikawa; Hiroshi Endo; Sou Nakamura; Akitsu Hotta; Koji Eto

  Blood, 02 Dec. 2016

  
• On-chip monitoring of megakaryocytes in shear flow environment.

  Kazuya Tashiro; Shinya Sakuma; Keitaro Ito; Sou Nakamura; Koji Eto; Toshio Fukuda; Fumihito Arai

  2015

  
• Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.

  Sou Nakamura; Naoya Takayama; Shinji Hirata; Hideya Seo; Hiroshi Endo; Kiyosumi Ochi; Ken-ichi Fujita; Tomo Koike; Ken-ichi Harimoto; Takeaki Dohda; Akira Watanabe; Keisuke Okita; Nobuyasu Takahashi; Akira Sawaguchi; Shinya Yamanaka; Hiromitsu Nakauchi; Satoshi Nishimura; Koji Eto

  Cell stem cell, 03 Apr. 2014

  
• Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.

  Shinji Hirata; Naoya Takayama; Ryoko Jono-Ohnishi; Hiroshi Endo; Sou Nakamura; Takeaki Dohda; Masanori Nishi; Yuhei Hamazaki; Ei-ichi Ishii; Shin Kaneko; Makoto Otsu; Hiromitsu Nakauchi; Shinji Kunishima; Koji Eto

  The Journal of clinical investigation, Sep. 2013

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• Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes.

  Yosuke Nakagawa; Sou Nakamura; Masahiro Nakajima; Hiroshi Endo; Takeaki Dohda; Naoya Takayama; Hiromitsu Nakauchi; Fumihito Arai; Toshio Fukuda; Koji Eto

  Experimental hematology, Aug. 2013

  
• Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells.

  Sho-Ichi Hirose; Naoya Takayama; Sou Nakamura; Kazumichi Nagasawa; Kiyosumi Ochi; Shinji Hirata; Satoshi Yamazaki; Tomoyuki Yamaguchi; Makoto Otsu; Shinya Sano; Nobuyasu Takahashi; Akira Sawaguchi; Mamoru Ito; Takashi Kato; Hiromitsu Nakauchi; Koji Eto

  Stem cell reports, 2013

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• Production system of platelet from iPS cells by two-way flow bioreactor.

  Yosuke Nakagawa; Seiichi Ikeda; Toshio Fukuda; Fumihito Arai; Sou Nakamura; Koji Eto

  2012

  
• Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.

  Naoya Takayama; Satoshi Nishimura; Sou Nakamura; Takafumi Shimizu; Ryoko Ohnishi; Hiroshi Endo; Tomoyuki Yamaguchi; Makoto Otsu; Ken Nishimura; Mahito Nakanishi; Akira Sawaguchi; Ryozo Nagai; Kazutoshi Takahashi; Shinya Yamanaka; Hiromitsu Nakauchi; Koji Eto

  The Journal of experimental medicine, 20 Dec. 2010

  

Misc.

• iPSC-derived MSC supports the hHSPCs’ expansion through the IFN pathway in an IFN-independent manner

  KANASHIRO Maria Alejandra; PAUL Sudip Kumar; SONE Masamitsu; YOSHINO Ikuyo; TSUJIMURA Kyoko; NAKAMURA Sou; ETO Koji; ETO Koji; TAKAYAMA Naoya

  日本血液学会学術集会抄録(Web), 2023

  
• Silencing of p53 and CDKN1A improves the establishment of immortalized MK progenitors from hiPSCs

  高山直也; 曽根正光; 中村壮; 梅田禎子; 銀屋治巳; PAUL Sudip; KANASHIRO Alejandra; 大島基彦; 中村英美里; 原田康男; 辻村恭子; 更屋敦則; 山口智之; 杉本直志; 岩間厚志; 江藤浩之; 江藤浩之

  日本血液学会学術集会抄録(Web), 2021

  
• Epigenetic Memory Enables,the Dominant Generation of Adult-Type Erythrocytes From Human Induced Pluripotent Stem Cells

  Naoya Takayama; Shiya Sano; Takafumi Shimizu; Ryoichiro Kawahata; Hiroshi Endo; Sou Nakamura; Seishi Ogawa; Hiromitsu Nakauchi; Koji Eto

  BLOOD, Nov. 2010

  
• 【ヒトの再生をめぐる諸問題】iPS細胞由来血小板製剤の開発

  中村 壮; 江藤 浩之

  HORMONE FRONTIER IN GYNECOLOGY, Mar. 2023

  
• iPS細胞由来血小板製剤の開発

  中村 壮; 江藤 浩之

  検査と技術, Jan. 2023

  
• High-Vorticity with Periodic Flow Enhances in Vitro Biogenesis of Healthy Platelets from iPSC-Derived-Megakaryocytes

  Yukitaka Ito; Sou Nakamura; Tomohiro Shigemori; Naoshi Sugimoto; Yoshikazu Kato; Kazuya Hashimoto; Naohide Watanabe; Masayuki Nogawa; Makoto Handa; Satoshi Nishimura; Koji Eto

  BLOOD, Dec. 2016

  
• Direct and Continuous Inhibition of ADAM17 Using a Novel Selective Inhibitor Restores Functional Platelet Yield From Human Pluripotent Stem Cells

  Shinji Hirata; Ryoko Jono-Ohnishi; Satoshi Nishimura; Naoya Takayama; Sou Nakamura; Hiromitsu Nakauchi; Takahiko Murata; Koji Eto

  BLOOD, Nov. 2011

  
• Platelet Production System Using An Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells

  Sou Nakamura; Naoya Takayama; Hiromitsu Nakauchi; Koji Eto

  BLOOD, Nov. 2011

  
• Platelet Production System Using An Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells

  Sou Nakamura; Naoya Takayama; Hiromitsu Nakauchi; Koji Eto

  BLOOD, Nov. 2011

  
• ESTABLISHMENT OF AN IN VITRO MODEL FOR THE SKEWED MEGAKARYOPOIESIS BY CALRETICULIN MUTATION IN HUMAN CELLS

  H. Takei; S. Mano; N. Masubuchi; Y. Mizukami; S. Morishita; M. Imai; Y. Edahiro; Y. Hironaka; M. Nudejima; S. Tsuneda; H. Endo; S. Nakamura; K. Eto; A. Ohsaka; M. Araki; N. Komatsu

  HAEMATOLOGICA, Jun. 2017

  
• Cancellation of c-MYC Silencing in Human Induced Pluripotent Stem Cells Contributes to the Efficient in Vitro Production of Platelets with the Ability of Hemostasis In Vivo.

  Naoya Takayama; Sou Nakamura; Satoshi Nishimura; Ryoko Ohnishi; Kazutoshi Takahashi; Shinya Yamanaka; Koji Eto; Hiromitsu Nakauchi

  BLOOD, Nov. 2009

  
• 【血液疾患と血球分化】血小板産生における流体力学機序 乱流による血小板大量産生

  杉本 直志; 中村 壮; 江藤 浩之

  血液内科, Jan. 2021

  
• 新規物理化学制御機構が1,000億個の血小板作製を可能にする

  中村 壮; 江藤 浩之

  臨床血液, Jun. 2020

  
• iPS細胞由来巨核球系前駆細胞株を用いたアナグレリドによる血小板産生抑制機構の解明

  高石 浩司; 武内 正博; 塚本 祥吉; 高山 直也; 大島 基彦; 中村 壮; 江藤 浩之; 岩間 厚志; 横手 幸太郎; 中世古 知昭; 堺田 惠美子

  日本臨床分子医学会学術総会プログラム・抄録集, Apr. 2019

  
• Environmental Cell-Matrix Adhesion Modulates Pluripotent Stem Cell Fate Toward Definitive Hemogenic Endothelium and Hematopoietic Progenitor Cells

  Akinori Yuzuriha; Sou Nakamura; Toshie Kusunoki; Takuya Matsumoto; Naoshi Sugimoto; Kiyotoshi Sekiguchi; Koji Eto

  BLOOD, Nov. 2018

  
• 新規の物理化学調節機構が1011個の血小板製造を可能にする(Novel physico-chemical regulation mechanism enables to manufacture 1011 order platelets)

  中村 壮; 伊東 幸敬; 杉本 直志; 加藤 好一; 佐久間 臣耶; 伊藤 啓太郎; 公文 広樹; 大野 美紀子; 西 英一郎; 新井 史人; 西村 智; 江藤 浩之

  臨床血液, Sep. 2018

  
• HLAクラスI欠失ヒトiPS細胞由来血小板の抗HLA抗体およびNK細胞に対する免疫逃避(HLA class-I depleted human iPSC-derived platelets evade anti-HLA and NK cell immunity)

  杉本 直志; 鈴木 大助; シャオミン・フェング; 吉川 典秀; 赤坂 まりな; 中村 壮; 遠藤 大; 堀田 秋津; 滝澤 仁; 江藤 浩之

  臨床血液, Sep. 2018

  
• iPS血小板とiPS赤血球 iPS細胞由来血小板の品質評価(献血由来血小板との違い)

  渕崎 晶弘; 森 純平; 越智 洋輔; 林 智也; 田中 光信; 寺田 周弘; 寺田 あかね; 木村 貴文; 谷 慶彦; 下垣 一成; 高橋 順子; 杉本 直志; 中村 壮; 清水 伸; 江藤 浩之

  日本輸血細胞治療学会誌, Apr. 2018

  
• カルレチキュリン変異を有する血球前駆細胞は巨核球への分化偏向性を有する

  竹井 拓; 眞野 修一; 増渕 菜弥; 水上 喜久; 今井 美沙; 森下 総司; 枝廣 陽子; 弘中 由美; ぬで島 麻衣; 常田 聡; 遠藤 大; 中村 壮; 江藤 浩之; 大坂 顯通; 荒木 真理人; 小松 則夫

  生命科学系学会合同年次大会, Dec. 2017

  
• iPS血小板は、献血PC製剤とは別物か?

  江藤 浩之; 中村 壮; 清水 伸; 杉本 直志; 広瀬 秀徳; 重盛 智大; 伊東 幸敬; 西河 芳樹; 下垣 一成; 高橋 順子; 木村 貴文; 谷 慶彦; 寺田 周弘; 渡邊 直英; 半田 誠; 野川 誠之

  日本輸血細胞治療学会誌, Jun. 2017

  
• NK細胞から見たHLA欠失血小板の有用性と安全性の保証

  鈴木大助; 杉本直志; 吉川典秀; 中村壮; 遠藤大; 堀田秋津; 江藤浩之

  再生医療, 2017

  
• 【血球の増加と減少】iPS細胞からの血小板分化と臨床応用

  中村 壮; 江藤 浩之

  小児内科, Jul. 2016

  
• iPS細胞技術に基づくHLA欠失血小板の作製と実用可能性の検証

  鈴木大助; 杉本直志; 吉川典秀; 中村壮; 遠藤大; 堀田秋津; 江藤浩之

  再生医療, 2016

  
• 新規低分子TPO受容体アゴニストTA-316を用いたiPS細胞由来不死化巨核球株(imMKCLs)からの血小板産生

  相原 彩子[大谷]; 小池 朋; 安部 菜月; 中村 隆典; 中村 壮; 西野 泰斗; 中内 啓光; 江藤 浩之

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• iPS細胞研究最前線 疾患モデルから臓器再生まで(Vol.19) ヒトiPS細胞を用いた血小板・赤血球製剤の開発

  中村 壮; 江藤 浩之

  医学のあゆみ, Mar. 2015

  
• 【血小板研究の最近の進歩】ヒトES/iPS細胞を用いた不死化巨核球細胞株の作製

  中村 壮; 江藤 浩之

  医学のあゆみ, Oct. 2014

  
• ヒト巨核球の自己複製と成熟スイッチの制御機構

  江藤 浩之; 中村 壮

  日本血栓止血学会誌, Apr. 2014

  
• 1P1-D09 Construction of high efficiency platelet collection system(Bio Assembler for 3D Cellular System Innovation)

  NAKAGAWA Yosuke; NAKAJIMA Masahiro; IKEDA Seiichi; FUKUDA Toshio; ARAI Fumihito; NAKAMURA Sou; ETO Koji

  ロボティクス・メカトロニクス講演会講演概要集, 22 May 2013

  
• ヒト多能性幹細胞を用いた血小板産生技術の開発

  中村 壮; 江藤 浩之

  日本血栓止血学会誌, Apr. 2013

  
• ヒト多能性幹細胞を用いた血小板再生

  中村 壮; 高山 直也; 江藤 浩之

  人工血液, Apr. 2012

  
• 体性幹細胞とiPS細胞 ヒトiPS細胞からの血液細胞誘導(医療応用への可能性)

  高山 直也; 西村 智; 中村 壮; 清水 崇史; 大西 椋子; 遠藤 大; 大津 真; 高橋 和利; 山中 伸弥; 江藤 浩之; 中内 啓光

  Cytometry Research, Jun. 2010

  
• iPS・幹細胞研究によってわかってきた血栓・血管医学の最前線 ヒトES細胞・iPS細胞をソースとするin vitro血小板産生モデル

  江藤 浩之; 高山 直也; 大西 椋子; 中村 壮; 西村 智; 國島 伸治; 大津 真; 中内 啓光

  日本血栓止血学会誌, Apr. 2010

  
• c-MYC再活性化に伴うヒトiPS細胞からの効率の良い巨核球/血小板産生法の確立

  高山 直也; 中村 壮; 大西 椋子; 澤口 朗; 高橋 和利; 山中 伸弥; 江藤 浩之; 中内 啓光

  臨床血液, Sep. 2009

  
• ヒトES細胞/iPS細胞をソースとする血液分化誘導法の樹立 ES(iPS)-Sac法の可能性

  高山 直也; 中村 壮; 大西 椋子; 三木 敬三郎; 澤口 朗; 江藤 浩之; 中内 啓光

  臨床血液, Sep. 2008

  
• ES細胞/iPS細胞から産生した血小板が有用であるための戦略

  錦井 秀和; 中村 壮; 高山 直也; 江藤 浩之; 中内 啓光

  臨床血液, Sep. 2008

  
• 再生医学とサイトメトリー ES・iPS細胞由来血小板製剤の産業化プロジェクト

  江藤 浩之; 高山 直也; 中内 啓光; 中村 壮; 三木 敬三郎

  Cytometry Research, Jun. 2008

  

External funds: Kakenhi

• Elucidating the fundamental mechanism of platelet biogenesis and its medical application

  Grant-in-Aid for Scientific Research (S)

  Broad Section I

  Kyoto University

  江藤 浩之

  From 05 Jul. 2021, To 31 Mar. 2026, Granted

  造血システム;血小板;乱流;バイオリアクター;iPS細胞;脂質膜;巨核球;培養槽

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H05047/
• 流体刺激シグナルの解明に基づく連続血小板製造非定常培養機器の開発

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  江藤 浩之

  From 05 Apr. 2021, To 31 Mar. 2022, Discontinued

  血小板;巨核球;リアクター;乱流;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04957/
• New method for establishing self-renewing megakaryocyte cell lines using iPS cells

  Grant-in-Aid for Early-Career Scientists

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  Sou Nakamura

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  巨核球;iPS細胞;imMKCL;iPS;血小板;自己複製;c-MYC;巨核球分化;再生医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K18365/
• Mechanism of turbulence mediated platelet biogenesis and application to ex vivo manufacturing of platelets

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  KOJI ETO

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  血小板;巨核球;iPS細胞;乱流;せん断ずり応力;バイオリアクター;ずり応力;乱流エネルギー;細胞膜;エンドペプチダーゼ;turbulence;shear stress

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H04164/
• 巨核球成熟における一次絨毛由来小胞の生理機能解明および生体外血小板製造への応用

  Grant-in-Aid for Early-Career Scientists

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  中村 壮

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  巨核球成熟;カリウムイオン;血小板;cilia小胞;巨核球細胞株

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K18169/
• リンパ管腫症／ゴーハム病で認められた血小板活性化受容体CLEC-2異常の解析

  Grant-in-Aid for Scientific Research (B)

  Basic Section 54010:Hematology and medical oncology-related

  University of Yamanashi

  井上 克枝

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ゴーハム病;リンパ管腫症;血小板;CLEC-2;ポドプラニン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02932/
• Study of the regulation of self-renewal and differentiation of human hematopoietic stem cells via interferon signaling.

  Grant-in-Aid for Scientific Research (B)

  Basic Section 54010:Hematology and medical oncology-related

  Chiba University

  高山 直也

  From 01 Apr. 2024, To 31 Mar. 2029, Granted

  ヒト造血幹細胞;インターフェロンシグナル;造血支持細胞;間葉系幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02477/
• リンパ管腫症／ゴーハム病で認められた血小板活性化受容体CLEC-2異常の解析

  Grant-in-Aid for Scientific Research (B)

  Basic Section 54010:Hematology and medical oncology-related

  University of Yamanashi

  井上 克枝

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ゴーハム病;リンパ管種症;血小板;CLEC-2;ポドプラニン;リンパ管;リンパ管腫症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27623/
• Ca2+オシレーションにおける巨核球成熟メカニズムの解明

  Grant-in-Aid for Scientific Research (C)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  中村 壮

  From 01 Apr. 2025, To 31 Mar. 2028, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K15893/