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Ikeya, Makoto

Center for iPS Cell Research and Application (CiRA) Associate Professor

Ikeya, Makoto
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    Last Updated :2022/06/30

    Basic Information

    Concurrent Affiliation

    • Center for iPS Cell Research and Application (CiRA), iPS細胞研究所 臨床応用研究部門, 准教授

    Academic Degree

    • 修士(理学)(京都大学)
    • 博士(理学)(京都大学)

    Language of Instruction

    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2022/06/30

      Research

      Research Topics, Overview of the research

      • Research Topics

        Applicaton of iPSCs for rare and intractable bone and cartilage diseases
      • Overview of the research

        難治性骨軟骨疾患罹患者よりiPS細胞を樹立し、シャーレ上で病態再現を行って病態の解明を行うとともに、それに基づき新しい治療法を開発する。

      Research Interests

      • Regenerative medicine
      • Drug discovery
      • Fibrodysplasia Ossificans Progressiva
      • induced pluripotent stem cells
      • Pluripotent stem cells
      • Mesenchymal Stem Cells
      • neural crest cells

      Research Areas

      • Life sciences, Medical biochemistry
      • Life sciences, Cell biology
      • Life sciences, Orthopedics
      • Life sciences, Developmental biology

      Papers

      • Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice
        Aya Harada; Megumi Goto; Atsuya Kato; Nana Takenaka-Ninagawa; Akito Tanaka; Satoru Noguchi; Makoto Ikeya; Hidetoshi Sakurai
        Frontiers in Cell and Developmental Biology, 23 Nov. 2021
      • Species-specific oscillation periods of human and mouse segmentation clocks are due to cell autonomous differences in biochemical reaction parameters
        Mitsuhiro Matsuda; Hanako Hayashi; Jordi Garcia-Ojalvo; Kumiko Yoshioka-Kobayashi; Ryoichiro Kageyama; Yoshihiro Yamanaka; Makoto Ikeya; Junya Toguchida; Cantas Alev; Miki Ebisuya
        bioRxiv, May 2019
      • ヒトiPS細胞から作製された間葉系前駆細胞を利用した骨格筋疾患治療
        竹中 菜々; 金森 洋子; 池谷 真; 櫻井 英俊
        理学療法学Supplement, 2015
      • Collagen-VI supplementation by cell transplantation improves muscle regeneration in Ullrich congenital muscular dystrophy model mice
        Nana Takenaka-Ninagawa; Jinsol Kim; Mingming Zhao; Masae Sato; Tatsuya Jonouchi; Megumi Goto; Clémence Kiho Bourgeois Yoshioka; Rukia Ikeda; Aya Harada; Takahiko Sato; Makoto Ikeya; Akiyoshi Uezumi; Masashi Nakatani; Satoru Noguchi; Hidetoshi Sakurai
        Stem Cell Research & Therapy, Dec. 2021
      • Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture.
        Taiki Nakajima; Akihiro Nakahata; Naoki Yamada; Keiko Yoshizawa; Tomoaki M Kato; Mio Iwasaki; Chengzhu Zhao; Hiroshi Kuroki; Makoto Ikeya
        Nature communications, 18 Aug. 2021
      • Bio-3D printing iPSCs-derived human chondrocytes for articular cartilage regeneration
        Anna Nakamura; Daiki Murata; Ryota Fujimoto; Sakura Tamaki; Sanae Nagata; Makoto Ikeya; Junya Toguchida; Koichi Nakayama
        Biofabrication, 11 Aug. 2021
      • In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells.
        Masayoshi Yoshimatsu; Hiroe Ohnishi; Chengzhu Zhao; Yasuyuki Hayashi; Fumihiko Kuwata; Shinji Kaba; Hideaki Okuyama; Yoshitaka Kawai; Nao Hiwatashi; Yo Kishimoto; Tatsunori Sakamoto; Makoto Ikeya; Koichi Omori
        Stem cell research, Apr. 2021, Peer-reviewed
      • Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva.
        Francesc Ventura; Eleanor Williams; Makoto Ikeya; Alex N Bullock; Peter Ten Dijke; Marie-José Goumans; Gonzalo Sanchez-Duffhues
        Biomedicines, 19 Feb. 2021, Peer-reviewed
      • Pluripotent stem cells in developmental biology (part 2).
        Makoto Ikeya; Yayoi Toyooka; Mototsugu Eiraku
        Development, growth & differentiation, Feb. 2021
      • Pluripotent stem cells in developmental biology.
        Makoto Ikeya; Yayoi Toyooka; Mototsugu Eiraku
        Development, growth & differentiation, Jan. 2021
      • Development of pluripotent stem cell-based human tenocytes.
        Taiki Nakajima; Makoto Ikeya
        Development, growth & differentiation, Jan. 2021, Peer-reviewed, Last author, Corresponding author
      • ヒトiPS細胞由来間葉系間質細胞による6型コラーゲン補充は、ウルリッヒ型筋ジストロフィー(UCMD)モデルマウスの筋再生不全を改善する
        竹中 菜々; Kim Jin Sol; 趙 明明; 佐藤 優江; 城之内 達也; 後藤 萌; 吉岡クレモンス 紀穂; 池田 留輝愛; 池谷 真; 上住 聡芳; 佐藤 貴彦; 野口 悟; 櫻井 英俊
        日本筋学会学術集会プログラム・抄録集, Dec. 2020
      • Olfactomedin-like 3 promotes PDGF-dependent pericyte proliferation and migration during embryonic blood vessel formation.
        Beat A Imhof; Romain Ballet; Philippe Hammel; Stéphane Jemelin; Sarah Garrido-Urbani; Makoto Ikeya; Thomas Matthes; Marijana Miljkovic-Licina
        FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Nov. 2020, Peer-reviewed
      • Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
        Mitsuhiro Matsuda; Hanako Hayashi; Jordi Garcia-Ojalvo; Kumiko Yoshioka-Kobayashi; Ryoichiro Kageyama; Yoshihiro Yamanaka; Makoto Ikeya; Junya Toguchida; Cantas Alev; Miki Ebisuya
        Science (New York, N.Y.), 18 Sep. 2020, Peer-reviewed
      • Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration.
        Sadaki Mitsuzawa; Chengzhu Zhao; Ryosuke Ikeguchi; Tomoki Aoyama; Daisuke Kamiya; Maki Ando; Hisataka Takeuchi; Shizuka Akieda; Koichi Nakayama; Shuichi Matsuda; Makoto Ikeya
        Scientific reports, 21 Jul. 2020, Peer-reviewed
      • Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model.
        Mingming Zhao; Atsutoshi Tazumi; Satoru Takayama; Nana Takenaka-Ninagawa; Minas Nalbandian; Miki Nagai; Yumi Nakamura; Masanori Nakasa; Akira Watanabe; Makoto Ikeya; Akitsu Hotta; Yuta Ito; Takahiko Sato; Hidetoshi Sakurai
        Stem cell reports, 14 Jul. 2020, Peer-reviewed
      • A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells.
        Hiraku Tsujimoto; Tomoko Kasahara; Shin-Ichi Sueta; Toshikazu Araoka; Satoko Sakamoto; Chihiro Okada; Shin-Ichi Mae; Taiki Nakajima; Natsumi Okamoto; Daisuke Taura; Makoto Nasu; Tatsuya Shimizu; Makoto Ryosaka; Zhongwei Li; Masakatsu Sone; Makoto Ikeya; Akira Watanabe; Kenji Osafune
        Cell reports, 07 Apr. 2020, Peer-reviewed
      • ラット四肢移植モデルに対するヒトiPS細胞由来間葉系幹細胞の免疫抑制効果の検討
        光澤 定己; 池口 良輔; 青山 朋樹; 安藤 麻紀; 竹内 久貴; 野口 貴志; 太田 壮一; 趙 成珠; 池谷 真; 松田 秀一
        日本手外科学会雑誌, Apr. 2020
      • ヒトiPS細胞由来間葉系幹細胞から作成したBio 3D conduitを用いた末梢神経の再生
        光澤 定己; 池口 良輔; 青山 朋樹; 安藤 麻紀; 竹内 久貴; 野口 貴志; 太田 壮一; 趙 成珠; 池谷 真; 松田 秀一
        日本手外科学会雑誌, Apr. 2020
      • Recapitulating the human segmentation clock with pluripotent stem cells.
        Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Thomas L Maurissen; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Noriaki Kawakami; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev
        Nature, Apr. 2020, Peer-reviewed
      • Insights into the biology of fibrodysplasia ossificans progressiva using patient-derived induced pluripotent stem cells.
        Taiki Nakajima; Makoto Ikeya
        Regenerative therapy, Dec. 2019, Peer-reviewed
      • Induced pluripotent stem cell-derived mesenchymal stem cells prolong hind limb survival in a rat vascularized composite allotransplantation model.
        Sadaki Mitsuzawa; Ryosuke Ikeguchi; Tomoki Aoyama; Maki Ando; Hisataka Takeuchi; Hirofumi Yurie; Hiroki Oda; Takashi Noguchi; Souichi Ohta; Chengzhu Zhao; Makoto Ikeya; Shuichi Matsuda
        Microsurgery, Nov. 2019, Peer-reviewed
      • Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis.
        Souta Motoike; Mikihito Kajiya; Nao Komatsu; Susumu Horikoshi; Tomoya Ogawa; Hisakatsu Sone; Shinji Matsuda; Kazuhisa Ouhara; Tomoyuki Iwata; Noriyoshi Mizuno; Tsuyoshi Fujita; Makoto Ikeya; Hidemi Kurihara
        International journal of molecular sciences, 15 Aug. 2019, Peer-reviewed
      • In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes.
        Shunsuke Kawai; Hiroyuki Yoshitomi; Junko Sunaga; Cantas Alev; Sanae Nagata; Megumi Nishio; Masataka Hada; Yuko Koyama; Maya Uemura; Kazuya Sekiguchi; Hirotsugu Maekawa; Makoto Ikeya; Sakura Tamaki; Yonghui Jin; Yuki Harada; Kenichi Fukiage; Taiji Adachi; Shuichi Matsuda; Junya Toguchida
        Nature biomedical engineering, Jul. 2019, Peer-reviewed
      • TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing.
        Tatsuya Katsuno; Inna A Belyantseva; Alexander X Cartagena-Rivera; Keisuke Ohta; Shawn M Crump; Ronald S Petralia; Kazuya Ono; Risa Tona; Ayesha Imtiaz; Atteeq Rehman; Hiroshi Kiyonari; Mari Kaneko; Ya-Xian Wang; Takaya Abe; Makoto Ikeya; Cristina Fenollar-Ferrer; Gavin P Riordan; Elisabeth A Wilson; Tracy S Fitzgerald; Kohei Segawa; Koichi Omori; Juichi Ito; Gregory I Frolenkov; Thomas B Friedman; Shin-Ichiro Kitajiri
        JCI insight, 20 Jun. 2019, Peer-reviewed
      • In Vitro Generation of Somite Derivatives from Human Induced Pluripotent Stem Cells.
        Taiki Nakajima; Hidetoshi Sakurai; Makoto Ikeya
        Journal of visualized experiments : JoVE, 25 Apr. 2019, Peer-reviewed
      • Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells.
        Misato Iwashita; Hatsumi Ohta; Takahiro Fujisawa; Minyoung Cho; Makoto Ikeya; Satoru Kidoaki; Yoichi Kosodo
        Scientific reports, 28 Feb. 2019, Peer-reviewed
      • Modeling the Human Segmentation Clock with Pluripotent Stem Cells
        Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K. Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev
        bioRxiv, Feb. 2019
      • An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva.
        Kyosuke Hino; Chengzhu Zhao; Kazuhiko Horigome; Megumi Nishio; Yasue Okanishi; Sanae Nagata; Shingo Komura; Yasuhiro Yamada; Junya Toguchida; Akira Ohta; Makoto Ikeya
        Stem cell reports, 13 Nov. 2018, Peer-reviewed
      • Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells.
        Taiki Nakajima; Mitsuaki Shibata; Megumi Nishio; Sanae Nagata; Cantas Alev; Hidetoshi Sakurai; Junya Toguchida; Makoto Ikeya
        Development (Cambridge, England), 23 Aug. 2018, Peer-reviewed
      • Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells.
        Chengzhu Zhao; Makoto Ikeya
        Stem cells international, 2018, Peer-reviewed
      • Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.
        Kyosuke Hino; Kazuhiko Horigome; Megumi Nishio; Shingo Komura; Sanae Nagata; Chengzhu Zhao; Yonghui Jin; Koichi Kawakami; Yasuhiro Yamada; Akira Ohta; Junya Toguchida; Makoto Ikeya
        The Journal of clinical investigation, 01 Sep. 2017, Peer-reviewed
      • Enhanced mTOR signaling triggered by Activin-A in chondrogenesis of fibrodysplasia ossificans progressiva (FOP)
        Hino K; Horigome K; Nishio M; Komura S; Nagata S; Zhao C; Jin Y; Kawakami K; Yamada Y; Ohta A; Toguchida J; Ikeya M
        J Clin Invest, Jul. 2017, Peer-reviewed
      • SOX10-Nano-Lantern Reporter Human iPS Cells; A Versatile Tool for Neural Crest Research.
        Tomoko Horikiri; Hiromi Ohi; Mitsuaki Shibata; Makoto Ikeya; Morio Ueno; Chie Sotozono; Shigeru Kinoshita; Takahiko Sato
        PloS one, 2017, Peer-reviewed
      • Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair.
        Ryota Chijimatsu; Makoto Ikeya; Yukihiko Yasui; Yasutoshi Ikeda; Kosuke Ebina; Yu Moriguchi; Kazunori Shimomura; David A Hart; Yoshikawa Hideki; Nakamura Norimasa
        Stem cells international, 2017, Peer-reviewed
      • BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.
        Yohei Hayashi; Edward C Hsiao; Salma Sami; Mariselle Lancero; Christopher R Schlieve; Trieu Nguyen; Koyori Yano; Ayako Nagahashi; Makoto Ikeya; Yoshihisa Matsumoto; Ken Nishimura; Aya Fukuda; Koji Hisatake; Kiichiro Tomoda; Isao Asaka; Junya Toguchida; Bruce R Conklin; Shinya Yamanaka
        Proceedings of the National Academy of Sciences of the United States of America, 15 Nov. 2016, Peer-reviewed
      • Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives.
        Fabian Oceguera-Yanez; Shin-Il Kim; Tomoko Matsumoto; Ghee Wan Tan; Long Xiang; Takeshi Hatani; Takayuki Kondo; Makoto Ikeya; Yoshinori Yoshida; Haruhisa Inoue; Knut Woltjen
        Methods (San Diego, Calif.), 15 May 2016, Peer-reviewed
      • [Application of disease-specific iPS cells for intractable diseases-from pathomechanisms to drug discovery].
        Junya Toguchida; Kyosuke Hino; Makoto Ikeya
        Clinical calcium, Apr. 2016, Peer-reviewed
      • Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.
        Kyosuke Hino; Makoto Ikeya; Kazuhiko Horigome; Yoshihisa Matsumoto; Hayao Ebise; Megumi Nishio; Kazuya Sekiguchi; Mitsuaki Shibata; Sanae Nagata; Shuichi Matsuda; Junya Toguchida
        Proceedings of the National Academy of Sciences of the United States of America, 15 Dec. 2015, Peer-reviewed
      • Application of patients - derived iPS cells for intractable musculoskeletal diseases.
        Junya Toguchida; Koji Yokoyama; Makoto Ikeya; Toshio Heike
        Nihon rinsho. Japanese journal of clinical medicine, Jun. 2015, Peer-reviewed
      • New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva.
        Yoshihisa Matsumoto; Makoto Ikeya; Kyosuke Hino; Kazuhiko Horigome; Makoto Fukuta; Makoto Watanabe; Sanae Nagata; Takuya Yamamoto; Takanobu Otsuka; Junya Toguchida
        Stem cells (Dayton, Ohio), Jun. 2015, Peer-reviewed
      • SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier.
        Sakura Tamaki; Makoto Fukuta; Kazuya Sekiguchi; Yonghui Jin; Sanae Nagata; Kazuo Hayakawa; Sho Hineno; Takeshi Okamoto; Makoto Watanabe; Knut Woltjen; Makoto Ikeya; Tomohisa Kato Jr; Junya Toguchida
        PloS one, 2015, Peer-reviewed
      • Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.
        Yonghui Jin; Hassan Elalaf; Makoto Watanabe; Sakura Tamaki; Sho Hineno; Kazuhito Matsunaga; Knut Woltjen; Yukiko Kobayashi; Sanae Nagata; Makoto Ikeya; Tomohisa Kato Jr; Takeshi Okamoto; Shuichi Matsuda; Junya Toguchida
        PloS one, 2015, Peer-reviewed
      • Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.
        Koji Yokoyama; Makoto Ikeya; Katsutsugu Umeda; Hirotsugu Oda; Seishiro Nodomi; Akira Nasu; Yoshihisa Matsumoto; Kazushi Izawa; Kazuhiko Horigome; Toshimasa Kusaka; Takayuki Tanaka; Megumu K Saito; Takahiro Yasumi; Ryuta Nishikomori; Osamu Ohara; Naoki Nakayama; Tatsutoshi Nakahata; Toshio Heike; Junya Toguchida
        Arthritis & rheumatology (Hoboken, N.J.), Jan. 2015, Peer-reviewed
      • Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media.
        Makoto Fukuta; Yoshinori Nakai; Kosuke Kirino; Masato Nakagawa; Kazuya Sekiguchi; Sanae Nagata; Yoshihisa Matsumoto; Takuya Yamamoto; Katsutsugu Umeda; Toshio Heike; Naoki Okumura; Noriko Koizumi; Takahiko Sato; Tatsutoshi Nakahata; Megumu Saito; Takanobu Otsuka; Shigeru Kinoshita; Morio Ueno; Makoto Ikeya; Junya Toguchida
        PloS one, 2014, Peer-reviewed
      • Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
        Yoshihisa Matsumoto; Yohei Hayashi; Christopher R Schlieve; Makoto Ikeya; Hannah Kim; Trieu D Nguyen; Salma Sami; Shiro Baba; Emilie Barruet; Akira Nasu; Isao Asaka; Takanobu Otsuka; Shinya Yamanaka; Bruce R Conklin; Junya Toguchida; Edward C Hsiao
        Orphanet journal of rare diseases, 09 Dec. 2013, Peer-reviewed
      • iPS細胞技術を用いた滑膜肉腫起源の同定への試み
        福田 誠; 早川 和男; 玉置 さくら; 佐藤 信吾; 池谷 真; 大塚 隆信; Woltjen Knut; 戸口田 淳也
        日本整形外科学会雑誌, Aug. 2013
      • 骨・軟部腫瘍の発生機構 多能性幹細胞を用いた融合癌蛋白標的遺伝子の同定
        早川 和男; 池谷 真; 福田 誠; ウォルテン・クヌート; 玉置 さくら; 高原 直子; 松本 佳久; 佐藤 信吾; 大塚 隆信; 戸口田 淳也
        日本整形外科学会雑誌, Jun. 2013
      • Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells.
        Kazuo Hayakawa; Makoto Ikeya; Makoto Fukuta; Knut Woltjen; Sakura Tamaki; Naoko Takahara; Tomohisa Kato Jr; Shingo Sato; Takanobu Otsuka; Junya Toguchida
        Biochemical and biophysical research communications, 22 Mar. 2013, Peer-reviewed
      • Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin.
        Akira Nasu; Makoto Ikeya; Takuya Yamamoto; Akira Watanabe; Yonghui Jin; Yoshihisa Matsumoto; Kazuo Hayakawa; Naoki Amano; Shingo Sato; Kenji Osafune; Tomoki Aoyama; Takashi Nakamura; Tomohisa Kato; Junya Toguchida
        PloS one, 2013, Peer-reviewed
      • Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro.
        Akihito Tanaka; Knut Woltjen; Katsuya Miyake; Akitsu Hotta; Makoto Ikeya; Takuya Yamamoto; Tokiko Nishino; Emi Shoji; Atsuko Sehara-Fujisawa; Yasuko Manabe; Nobuharu Fujii; Kazunori Hanaoka; Takumi Era; Satoshi Yamashita; Ken-Ichi Isobe; En Kimura; Hidetoshi Sakurai
        PloS one, 2013, Peer-reviewed
      • Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.
        Makoto Ikeya; Kumi Fukushima; Masako Kawada; Sachiko Onishi; Yasuhide Furuta; Shigenobu Yonemura; Toshio Kitamura; Tetsuya Nosaka; Yoshiki Sasai
        Developmental biology, 15 Jan. 2010, Peer-reviewed
      • Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice
        Makoto Ikeya; Tetsuya Nosaka; Kumi Fukushima; Masako Kawada; Yasuhide Furuta; Toshio Kitamura; Yoshilzi Sasai
        MECHANISMS OF DEVELOPMENT, Sep. 2008, Peer-reviewed
      • The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo.
        Akiko Arakawa; Mami Matsuo-Takasaki; Akira Takai; Hidehiko Inomata; Michiru Matsumura; Makoto Ikeya; Kenzo Takahashi; Yoshiki Miyachi; Noriaki Sasai; Yoshiki Sasai
        Developmental biology, 01 Jun. 2007, Peer-reviewed
      • Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
        Makoto Ikeya; Masako Kawada; Hiroshi Kiyonari; Noriaki Sasai; Kazuki Nakao; Yasuhide Furuta; Yoshiki Sasai
        Development (Cambridge, England), Nov. 2006, Peer-reviewed
      • Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors.
        Makoto Sakuragi; Noriaki Sasai; Makoto Ikeya; Masako Kawada; Takayuki Onai; Tatsuya Katahira; Harukazu Nakamura; Yoshiki Sasai
        Mechanisms of development, Feb. 2006, Peer-reviewed
      • Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations.
        Makoto Ikeya; Masako Kawada; Yoko Nakazawa; Makoto Sakuragi; Noriaki Sasai; Morio Ueno; Hiroshi Kiyonari; Kazuki Nakao; Yoshiki Sasai
        The International journal of developmental biology, 2005, Peer-reviewed
      • Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord.
        Yuko Muroyama; Motoyuki Fujihara; Makoto Ikeya; Hisato Kondoh; Shinji Takada
        Genes & development, 01 Mar. 2002, Peer-reviewed
      • Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.
        M Nomi; I Oishi; S Kani; H Suzuki; T Matsuda; A Yoda; M Kitamura; K Itoh; S Takeuchi; K Takeda; S Akira; M Ikeya; S Takada; Y Minami
        Molecular and cellular biology, Dec. 2001, Peer-reviewed
      • Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal.
        T Kawauchi; M Ikeya; S Takada; K Ueda; M Shirai; Y Takihara; N Kioka; T Amachi
        Mechanisms of development, Aug. 2001, Peer-reviewed
      • Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.
        T Matsuda; M Nomi; M Ikeya; S Kani; I Oishi; T Terashima; S Takada; Y Minami
        Mechanisms of development, Jul. 2001, Peer-reviewed
      • Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression.
        M Ikeya; S Takada
        Mechanisms of development, May 2001, Peer-reviewed
      • Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.
        S Takeuchi; K Takeda; I Oishi; M Nomi; M Ikeya; K Itoh; S Tamura; T Ueda; T Hatta; H Otani; T Terashima; S Takada; H Yamamura; S Akira; Y Minami
        Genes to cells : devoted to molecular & cellular mechanisms, Jan. 2000, Peer-reviewed
      • [Roles of Wnt signals secreted from the developing neural tube].
        S Takada; M Ikeya
        Seikagaku. The Journal of Japanese Biochemical Society, Oct. 1999, Peer-reviewed
      • The roles of Wnt signaling in the developing dorsal neural tube
        M Ikeya; SMK Lee; AP McMahon; S Takada
        NEURAL DEVELOPMENT-BOOK, 1999, Peer-reviewed
      • Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.
        M Ikeya; S Takada
        Development (Cambridge, England), Dec. 1998, Peer-reviewed
      • Wnt signalling required for expansion of neural crest and CNS progenitors.
        M Ikeya; S M Lee; J E Johnson; A P McMahon; S Takada
        Nature, 30 Oct. 1997, Peer-reviewed

      Misc.

      • Application of iPS cells for rare and intractable bone and cartilage diseases
        松本 佳久; 池谷 真; 横山 宏司
        日本整形外科学会雑誌, Dec. 2015
      • Application of patients-derived iPS cells for in vitro recapitulation of pathologic condition : Bone and cartilage diseases
        戸口田 淳也; 池谷 真
        医学のあゆみ, 21 Mar. 2015
      • Recent Advances in the Field of Mesenchymal Stem Cells
        戸口田 淳也; 福田 誠; 池谷 真
        細胞工学, 2014
      • ヒトiPS細胞由来間葉系間質細胞による6型コラーゲン補充は,ウルリッヒ型筋ジストロフィー(UCMD)モデルマウスの筋再生不全を改善する
        竹中菜々; KIM Jin Sol; 趙明明; 佐藤優江; 城之内達也; 後藤萌; 吉岡クレモンス紀穂; 池田留輝愛; 池谷真; 上住聡芳; 佐藤貴彦; 野口悟; 櫻井英俊
        日本筋学会学術集会プログラム・抄録集, 2020
      • iPS細胞由来間葉系幹細胞から構築した三次元神経導管による末梢神経再生
        趙成珠; 光澤定己; 淘江宏文; 加治屋幹人; 山田尚基; 田中麻衣; 秋枝静香; 中山功一; 栗原英見; 松田秀一; 青山朋樹; 池口良輔; 池谷真
        日本再生医療学会総会(Web), 2019
      • Peripheral nerve regeneration in a rat crushed sciatic nerve model: Using a Bio 3D sheets generated from human iPSC-derived mesenchymal stromal cells
        Naoki Yamada; Chengzhu Zhao; Akira Ito; Tianshu Wang; Akihiro Nakahata; Nan Liang; Taiki Nakajima; Mai Tanaka; Shizuka Akieda; Koichi Nakayama; Masahiro Abo; Tomoki Aoyama; Makoto Ikeya
        2019, Peer-reviewed
      • ヒトiPS細胞由来骨格筋幹細胞を用いた筋ジストロフィーに対する細胞移植治療
        櫻井英俊; 田積充年; 田積充年; 高山了; 高山了; 竹中菜々; 趙明明; 佐藤優江; 池谷真; 堀田秋津; 佐藤貴彦; 伊東佑太; 関口清俊
        日本筋学会学術集会プログラム・抄録集, Aug. 2018
      • 運動器疾患の病態理解から治療法へ〜iPS細胞技術を中心に〜 ヒトiPS細胞由来骨格筋幹細胞を用いた筋ジストロフィーに対する細胞移植治療
        櫻井 英俊; 田積 充年; 高山 了; 竹中 菜々; 趙 明明; 佐藤 優江; 池谷 真; 堀田 秋津; 佐藤 貴彦; 伊東 佑太; 関口 清俊
        日本筋学会学術集会プログラム・抄録集, Aug. 2018
      • ヒトiPS細胞由来間葉系間質細胞を用いたウルリッヒ型筋ジストロフィー症に対する細胞移植治療研究
        竹中菜々; KIM Jinsol; 池谷真; 堀田秋津; 上住聡芳; 佐藤貴彦; 野口悟; 櫻井英俊
        日本再生医療学会総会(Web), 2018
      • iPS細胞を用いた筋ジストロフィーに対する細胞移植治療法の開発
        櫻井英俊; 趙明明; 高山了; 竹中菜々; 田積充年; 佐藤優江; 池谷真; 堀田秋津; 佐藤貴彦; 伊東佑太; 関口清俊
        日本再生医療学会総会(Web), 2018
      • 筋生物学の統合的理解にむけた新たな潮流 iPS細胞からの骨格筋幹細胞誘導と、筋ジストロフィーに対する再生医療への応用
        櫻井 英俊; 高山 了; 田積 充年; 竹中 菜々[蜷川]; 趙 明明; 池谷 真; 堀田 秋津; 佐藤 貴彦; 伊東 佑太
        生命科学系学会合同年次大会, Dec. 2017
      • ヒトiPS細胞由来間葉系前駆細胞(iMSC)を用いたウルリッヒ型筋ジストロフィー症に対する細胞治療法の開発
        竹中菜々; KIM Jin Sol; 伊東佑太; 上住聡芳; 池谷真; 野口悟; 櫻井英俊
        日本筋学会学術集会プログラム・抄録集, 03 Jul. 2017
      • iPS細胞を用いた筋ジストロフィーに対する細胞移植治療法の開発
        櫻井英俊; 高山了; 竹中菜々; 竹中菜々; 趙明明; 田積充年; 田積充年; 池谷真; 堀田秋津; 伊東佑太; 佐藤貴彦
        再生医療, 01 Feb. 2017
      • ヒトiPS細胞由来間葉系間質細胞(MSC)は骨格筋疾患治療に応用可能であるか
        竹中菜々; 竹中菜々; 池谷真; 櫻井英俊; 野口悟; 上住聡芳
        再生医療, 2017
      • 家族性OPLL患者由来のiPS細胞を用いたOPLL遺伝的要素の検討
        川井 俊介; 羽田 匡孝; 小山 優子; 池谷 真; Alev Cantas; 堀田 秋津; 池川 志郎; 中村 雅也; 松本 守雄; 吉富 啓之; 松田 秀一; 戸口田 淳也
        日本整形外科学会雑誌, Aug. 2016
      • iPS細胞を用いた運動器疾患治療への挑戦 疾患特異的iPS細胞を活用した骨格系疾患の病態解明・創薬
        戸口田 淳也; 日野 恭介; 池谷 真; 関口 和也; 金 永輝; 岡本 健; 吉富 啓之; 松田 秀一
        日本整形外科学会雑誌, Aug. 2016
      • 運動器再生医療の最前線 iPS細胞からの骨細胞系譜への誘導と応用
        戸口田 淳也; 川井 俊介; 日野 恭介; 池谷 真; アレブ・ジャンタッシュ; 吉富 啓之; 松田 秀一
        日本骨代謝学会学術集会プログラム抄録集, Jul. 2016
      • Modeling Charcot-Marie-Tooth disease using patient-induced pluripotent stem cells
        Morii F; Imamura K; Ohara R; Shibata M; Sekiguchi K; Ikeya M; Toguchida J; Mizuno T; Nakagawa M; Inoue H
        57th Annual Meeting of the Japanese Society of Neurology, Kobe., 18 May 2016
      • Pathology analysis of fibrodysplasia ossificans progressiva utilizing iPS cells
        松本 佳久; 日野 恭介; 池谷 真; 戸口田 淳也
        バイオサイエンスとインダストリー, 2016
      • 慢性自己炎症性疾患における成長軟骨板の病態
        戸口田 淳也; 横山 宏司; 池谷 真; 平家 俊男; 西小森 隆太
        臨床免疫・アレルギー科, Aug. 2015
      • 【再生医療-新たな医療を求めて-】 臨床応用を目指した基礎研究 疾患モデル細胞、iPS細胞を用いた毒性評価と創薬研究 疾患特異的iPS細胞を活用した筋骨格系難病研究
        戸口田 淳也; 横山 宏司; 池谷 真; 平家 俊男; 西小森 隆太
        日本臨床, Jun. 2015
      • 【病理医を誘うiPS細胞を使った疾患研究】 疾患特異的iPS細胞を活用した骨軟骨疾患研究
        戸口田 淳也; 池谷 真; 西小森 隆太
        病理と臨床, Jun. 2015
      • Modeling for hereditary neuropathy using patient-induced pluripotent stem cells
        Morii F; Ohara R; Imamura K; Shibata M; Sekiguchi K; Ikeya M; Toguchida J; Mizuno T; Nakagawa M; Inoue H
        56th Annual Meeting of the Japanese Society of Neurology, Niigata., 23 May 2015
      • 骨系統疾患の現状と展望(研究、診断、そして治療) 疾患特異的iPS細胞を活用した難治性骨軟骨疾患の病態解明
        戸口田 淳也; 松本 佳久; 横山 宏司; 松田 秀一; 西小森 隆太; 池谷 真
        日本整形外科学会雑誌, Mar. 2015
      • 【再生医療2015 幹細胞と疾患iPS細胞の研究最前線】 (第3章)疾患iPS細胞 疾患特異的iPS細胞を用いた難治性骨軟骨疾患の病態解析・創薬
        戸口田 淳也; 池谷 真; 西小森 隆太; 松本 佳久; 横山 宏司
        実験医学, Feb. 2015
      • 疾患特異的iPS細胞を用いたCINCA症候群における成長軟骨病態の解析
        戸口田淳也; 横山宏司; 玉置さくら; 小山優子; 池谷真; 田中孝之; 斎藤潤; 梅田雄嗣; 中畑龍俊; 平家俊男; 西小森隆太
        再生医療, 01 Feb. 2015
      • ヒト免疫とリウマチ性疾患 自己炎症性疾患とリウマチ疾患のcrossroad CINCA症候群/NOMIDの骨幹端過形成をとりあげて
        西小森 隆太; 横山 宏司; 梅田 雄嗣; 池谷 真; 中川 権史; 納富 誠司郎; 八角 高裕; 田中 孝之; 齋藤 潤; 小田 紘嗣; 小原 收; 中山 直樹; 戸口田 淳也; 平家 俊男
        日本リウマチ学会総会・学術集会プログラム・抄録集, Mar. 2014
      • 骨・軟部腫瘍 希少疾患に光明をもたらす夢の実現へ 新規治療戦略の開発をめざした肉腫起源細胞の探索
        戸口田 淳也; 玉置 さくら; 福田 誠; 池谷 真; 加藤 友久; 岡本 健; 大塚 隆信; 松田 秀一
        日本整形外科学会雑誌, Mar. 2014
      • Identification of Gene Sets Dysregulated by Mutant ACVR1 Gene Causing A Rare Intractable Disease, Fibrodysplasia Ossificance Progressiva.
        Yoshihisa Matsumoto; Makoto Ikeya; Takanobu Otsuka; Junya Toguchida
        JOURNAL OF BONE AND MINERAL RESEARCH, Feb. 2014
      • 自己炎症性疾患における診療研究の新展開 "炎症"と小児発熱性疾患 疾患特異的iPS細胞を用いたCINCA/NOMIDにおける骨幹端過形成の機序解明
        西小森 隆太; 横山 宏司; 梅田 雄嗣; 池谷 真; 中川 権史; 納富 誠司郎; 八角 高裕; 田中 孝之; 斉藤 潤; 小田 紘嗣; 小原 収; 中山 直樹; 戸口田 淳也; 平家 俊男
        日本小児科学会雑誌, Feb. 2014
      • 日本人の軟骨腫瘍におけるIDH遺伝子の突然変異スペクトラム(Mutation spectrum of IDH genes in Japanese cartilaginous tumors)
        金 永輝; Elalaf Hassan; 加藤 友久; 池谷 真; 永田 早苗; 仲俣 岳晴; 岡本 健; 松田 秀一; 戸口田 淳也
        日本癌学会総会記事, Oct. 2013
      • iPS細胞の基礎と応用(第3回)iPS細胞を使う : 骨の研究へ
        松本 佳久; 福田 誠; 池谷 真
        整形外科 = Orthopedic surgery, Aug. 2013
      • Induced pluripotent stem cells : present state and future perspectives for clinical applications
        池谷 真; 松本 佳久; 横山 宏司
        整形・災害外科, Apr. 2013
      • Application of iPS cell technology \nfor the analysis of origin-unknown sarcoma characterized by a specific fusion gene.
        Hayakawa K; Fukuta M; TamaiS; Kato T; Ikeya M; Otsuka T; Woltjen K; Toguchida J
        第17 回CTOS (2012.11.16.Prague), 16 Nov. 2012, Peer-reviewed
      • BMP-SMAD-ID signaling axis supports reprogramming to pluripotency
        Y. Hayashi; E. C. Hsiao; S. Sami; M. Lancero; C. R. Schlieve; T. Nguyen; K. Yano; A. Nagahashi; M. Ikeya; Y. Matsumoto; I. Asaka; J. Toguchida; B. R. Conklin; S. Yamanaka
        MOLECULAR BIOLOGY OF THE CELL, 2012
      • Proteomic analysis-based identification of proteins related \nto differentiation of human iPS cells into cartilage cells.
        Watanabe M; Nasu A; Kato T; Ikeya M; Toguchida J; Sato T
        第10 回ISSCR(2012.6.15.横浜), 2012, Peer-reviewed
      • Genetically matched human iPS cells revealed that the propensity for iPS cells to differentiate into cartilage lineage cells differs with clones, but not cell type of origin
        Nasu A; Kato T; Yamamoto T; Ikeya M; Toguchida J
        第10 回ISSCR(2012.6.15.横浜), 2012, Peer-reviewed
      • Understanding the pathology of the arthropathy in chronic infantile neurological cutaneous and articular \nsyndrome by using iPS cells technology
        Yokoyama K; Ikeya M; Nasu A; Tanaka T; Saito M; Umeda K; Nishikomori R; Nakahata T; Heike T; Toguchida J
        第10 回ISSCR(2012.6.15.横浜), 2012, Peer-reviewed
      • Establishment and functional \nanalysis of iPS cells with drug-inducible SYT-SSX fusion gene.
        Fukuta M; Hayakawa K; Tamaki S; Sato S; Ikeya M; Otsuka Y; Woltjen K; Toguchida J
        第10 回ISSCR(2012.6.14.横浜), 2012, Peer-reviewed
      • BMP-SMAD-ID axis promotes reprogramming to pluripotency.
        Hayashi Y; Hsiao E; Sami S; Lancero M; Schlieve C; Yano K; Nagahashi A; Ikeya M; Matsumoto Y; Asaka I; JToguchida J; Conckin B; Yamanaka S
        第10 回ISSCR(2012.6.14.横浜), 2012, Peer-reviewed
      • PS 細胞を用いた肉腫研究:滑膜肉腫の起源細胞の解明をめざして
        福田誠; 早川和男; 玉置さくら; 沖田圭介; 池谷真; Knut Woltjen; 大塚隆信; 戸口田淳也
        第27 回日本整形外科学会基礎学術集会(2012.10.26. 名古屋), 2012, Peer-reviewed
      • 人工多能性幹細胞を用いた希少難治性骨疾患への取り組み
        松本佳久; 池谷真; Edward Hsiao; 那須輝; 浅香勲; 大塚隆信; 戸口田淳也
        第27 回日本整形外科学会基礎学術集会(2012.10.26.名古屋), 2012, Peer-reviewed
      • 罹患者由来iPS 細部を用いたCINCA 症候群における関節病態の分子機構の解明
        横山宏司; 池谷真; 那須輝; 田中孝之; 斎藤潤; 梅田雄嗣; 西小森隆太; 中畑龍俊; 平家俊男; 戸口田淳也
        第27 回日本整形外科学会基礎学術集会(2012.10.26.名古屋), 2012, Peer-reviewed
      • イヌ体細胞由来人工多能性幹細胞の樹立
        早川和男; 加藤友久; 那須輝; 池谷真; 堀田秋津; 大塚隆信; 戸口田淳也
        第27 回日本整形外科学会基礎学術集会(2012.10.26.名古屋), 2012, Peer-reviewed
      • 肉腫の病態解明への幹細胞研究 の応用
        戸口田淳也; 玉置さくら; 早川和男; 福田誠; 高原直子; 池谷真; 加藤友久
        第71 回日本癌学会総会(2012.9.21.札幌), 2012, Peer-reviewed
      • 薬剤誘導型発現ベクターを用いたSYT-SSX 融合遺伝子導入iPS 細胞の樹立
        早川和男; 福田誠; 玉置さくら; 佐藤信吾; 池谷真; 大塚隆信; Knut Woltjen; 戸口田淳也
        第45 回日本整形外科学会骨軟部腫瘍学術 集会(2012.7.15.東京), 2012, Peer-reviewed
      • 同一ドナーの異なる組織より樹立したiPS 細胞の比較検討
        那須輝; 加藤友久; 山本拓也; 中村孝志; 池谷真; 戸口田淳也
        第11 回日本再生医療学会(2012.6.13.横浜), 2012, Peer-reviewed
      • iPS 細胞を用いたCINCA 症候群の関節病変の解析
        横山宏司; 池谷真; 那須輝; 田中孝之; 斎藤潤; 梅田雄嗣; 西小森隆太; 中畑龍俊; 平家俊男; 戸口田淳也
        第11 回日本再生医療学会(2012.6.13.横浜), 2012, Peer-reviewed
      • J.Generation of canine iPS cells and their \ncharcteristics
        Hayakawa K; Kato T; Nasu A; Ikeya M; Otsuka T; Toguchida J
        第9 回ISSCR(2011.6.17 Toronto), 2011, Peer-reviewed
      • iPS 細胞を用いた難治性骨疾患への取り組み
        松本佳久; 那須輝; 池谷真; 戸口田淳也
        京都大学再生医科学研究所学術講演会(2010.12.13 京都), 2010, Peer-reviewed
      • Essential pro-BMP roles of Crossveinless2 in mouse organogenesis
        Makoto Ikeya; Masako Kawada; Hiroshi Kiyonari; Noriaki Sasai; Kazuki Nakao; Yasuhide Furuta; Sasai
        DEVELOPMENTAL BIOLOGY, Jun. 2007

      Books and Other Publications

      • 連載iPS細胞の基礎と応用 第3回 iPS細胞を使うー骨の研究へ
        松本佳久; 福田誠; 池谷真; 戸口田淳也
        南江堂, 01 Aug. 2013, Not refereed
      • iPS細胞ーその基礎と臨床応用に向けた展望ー
        池谷真; 松本佳久; 横山宏司; 戸口田淳也
        整形・災害外科 第56巻第5号、4月臨時増刊号、507-514、金原出版株式会社, 2013, Not refereed
      • 難治性骨軟骨疾患罹患者由来iPS細胞を用いた病態再現と治療薬開発の試み
        松本佳久; 池谷 真; 戸口田淳也
        遺伝子医学MOOK 22号, 190-194, メディカルドゥ, 2012, Not refereed
      • 最新疾患モデルと病態解明、創薬応用研究、細胞医薬創製研究の最前線
        戸口田淳也; 池谷 真
        メディカルドゥ, 2012, Not refereed

      External funds: Kakenhi

      • 新規腱靭帯再生医療に向けた高機能靭帯節細胞誘導法の開発
        Grant-in-Aid for Scientific Research (B)
        Basic Section 56020:Orthopedics-related
        Kyoto University
        池谷 真
        From 01 Apr. 2020, To 31 Mar. 2023, Granted
        靱帯節細胞;靱帯再生;多能性幹細胞;再生医療;靭帯節細胞;靭帯再生
      • Development of periodontal tissue regenerative therapy by using neural crest-derived MSCs and cell clumps culture technique
        Grant-in-Aid for Scientific Research (B)
        Basic Section 57030:Conservative dentistry-related
        Hiroshima University
        Hidemi Kurihara
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        間葉系幹細胞集塊;C-MSCs;神経堤細胞由来間葉系幹細胞;iPS細胞;立体複合化
      • Induction of tendon/ligament progenitor cells from human iPSCs
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        CANTAS ALEV
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        Tendon Progenitor Cell;iPSCs;Mesoderm Differentiation;tendon progenitor cells;mesoderm differentiation;syndetome;Tendon Progenitor Cells;iPS細胞;腱誘導;中胚葉誘導;スクレラキシス;リポーター細胞
      • Identification of the cell-of-origin of ectopic bones using lineage tracing mice
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Makoto Ikeya
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        異所性骨化;細胞・組織;進行性骨化性線維異形成症
      • Development of a xeno-free induction and maintenance protocol for MSCs from PSCs
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Makoto IKEYA
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        間葉系幹細胞;再生医療
      • Functional analyses of mutant NLRP3 on the growth and differentiation of growth plate chondrocytes
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Junya Toguchida
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        CINCA症候群;NLRP3;成長軟骨;iPS細胞;成長板軟骨細胞;細胞間相互作用
      • Investigation of functional roles of mutant IDH as specific mutations in cartilage-forming tumors and its application for the development of treatment
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Junya Toguchida
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        chondrosarcoma;IDH;iPSC;p16;IDH遺伝子;軟骨形成性腫瘍;iPS細胞;軟骨腫瘍;間葉系幹細胞;神経幹細胞;ヒストンメチル化;軟骨形成腫瘍
      • Derivation of human PSC-derived mesodermal cells
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Makoto Ikeya
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        中胚葉細胞
      • Analysis of fibrodysplasia ossificans progressive by using iPSCs
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Makoto Ikeya
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        異所性骨化;進行性骨化性線維異形成症
      • Establishment of canine iPS cells for the study of disease-model dogs
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Junya TOGUCHIDA
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        iPS細胞;イヌ;疾患モデル
      • Investigation for the pathomechanism of cartilage-forming tumors by whole exome sequencing
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Junya TOGUCHIDA
        From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
        軟骨形成腫瘍;Maffucci症候群;iPS細胞;Ollier病;エクソーム解析
      • Establishment of the assay system of drug screening for fibrodysplasia ossificans progressiva
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Makoto IKEYA
        From 28 Apr. 2011, To 31 Mar. 2013, Project Closed
        進行性骨化症線維異形成症;進行性骨化性線維異形成症;異所性骨化;BMP受容体
      • Functional analysis of BMP binding protein, Cv2, in nephorogenesis
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Makoto IKEYA
        Project Closed
        遺伝学;発生・分化;細胞・組織;シグナル伝達;循環器・高血圧

      External funds: others

      • 機械刺激によるヒトiPS細胞からの中枢・末梢神経系への分化制御機構の解明と活用 (平成29年度分)
        二国間交流事業共同研究・セミナー
        From 01 Apr. 2017, To 31 Mar. 2018
        池谷 真
      • 機械刺激によるヒトiPS細胞からの中枢・末梢神経系への分化制御機構の解明と活用 (平成30年度分)
        二国間交流事業共同研究・セミナー
        From 01 Apr. 2018, To 31 Mar. 2019
        池谷 真
      • 再生医療用iPS 細胞ストック開発拠点
        再生医療実現拠点ネットワーク事業、再生医療実現拠点ネットワークプログラム
        From Apr. 2013, To Mar. 2023
        分担
      • 疾患特異的iPS 細胞を活用した筋骨格系難病研究
        再生医療実現拠点ネットワーク事業、再生医療実現拠点ネットワークプログラム
        From Jan. 2013, To Mar. 2017
        分担
      • ヒトiPS 細胞由来xeno-free 間葉系幹細胞作製技術の開発
        研究成果展開事業・研究成果最適展開支援プログラム(A-STEP)
        From Nov. 2012, To Oct. 2013
        代表
      list
        Last Updated :2022/06/30

        Education

        Teaching subject(s)

        • From 20 Jun. 2013, To 20 Jun. 2013
          医科学特論
          Spring, 医学研究科
        list
          Last Updated :2022/06/30

          Administration

          School management (title, position)

          • From 01 Apr. 2022, To 31 Mar. 2024
            京都大学動物実験委員会 委員

          Faculty management (title, position)

          • From 31 Mar. 2020, To 31 Mar. 2022
            CiRA研究インターンシップ委員会委員長、1号委員
          • From 01 Apr. 2014, To 31 Mar. 2020
            組換えDNA実験安全委員会3号委員
          • From 01 Apr. 2020, To 31 Mar. 2022
            共通機器管理運営委員会1号委員
          • From 01 Apr. 2019, To 31 Mar. 2023
            動物実験委員会2号委員

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