Basic Information

Concurrent Affiliation

• Center for iPS Cell Research and Application (CiRA), iPS細胞研究所 臨床応用研究部門, 准教授

Academic Degree

• 修士（理学）(京都大学)
• 博士（理学）(京都大学)

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-3930-8032

• J-Global ID

  201401056872162317

researchmap URL

• https://researchmap.jp/7000009013

Research

Research Topics, Overview of the research

• Research Topics

  Applicaton of iPSCs for rare and intractable bone and cartilage diseases

• Overview of the research

  難治性骨軟骨疾患罹患者よりiPS細胞を樹立し、シャーレ上で病態再現を行って病態の解明を行うとともに、それに基づき新しい治療法を開発する。

Research Interests

• Regenerative medicine
• Drug discovery
• Fibrodysplasia Ossificans Progressiva
• induced pluripotent stem cells
• Pluripotent stem cells
• Mesenchymal Stem Cells
• neural crest cells

Research Areas

• Life sciences, Medical biochemistry
• Life sciences, Cell biology
• Life sciences, Orthopedics
• Life sciences, Developmental biology

Papers

• BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling

  Chengzhu Zhao; Yoshiko Inada; Souta Motoike; Daisuke Kamiya; Kyosuke Hino; Makoto Ikeya

  EMBO Molecular Medicine, 03 Dec. 2024

  
• Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice.

  Megumi Yokomizo-Goto; Nana Takenaka-Ninagawa; Chengzhu Zhao; Clémence Kiho Bourgeois Yoshioka; Mayuho Miki; Souta Motoike; Yoshiko Inada; Denise Zujur; William Theoputra; Yonghui Jin; Junya Toguchida; Makoto Ikeya; Hidetoshi Sakurai

  Stem cell research & therapy, 07 Oct. 2024

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• 神経筋疾患克服へ向けた先端ゲノム創薬 iPS細胞技術を活用した筋疾患に対する治療法開発研究

  櫻井 英俊; 趙 明明; Nalbandian Harutiun Minas; 竹中 菜々[蜷川]; 原田 文; 池谷 真; 堀田 秋津; 山本 拓也; 上住 聡芳; 野口 悟

  日本筋学会学術集会プログラム・抄録集, Aug. 2022

  
• 健常ヒトiPS細胞由来間葉系間質細胞(iMSC)による6型コラーゲン補充は、ウルリッヒ型筋ジストロフィー(UCMD)の病態を改善する

  竹中 菜々; 後藤 萌; 池田 留輝愛; 吉岡ブルジョワ クレモンス紀穂; 田中 碧; 池谷 真; 櫻井 英俊

  理学療法学, Dec. 2021

  
• Induction of Functional Mesenchymal Stem/Stromal Cells from Human iPCs Via a Neural Crest Cell Lineage Under Xeno-Free Conditions

  Daisuke Kamiya; Nana Takenaka-Ninagawa; Souta Motoike; Mikihito Kajiya; Teppei Akaboshi; Chengzhu Zhao; Mitsuaki Shibata; Sho Senda; Yayoi Toyooka; Hidetoshi Sakurai; Hidemi Kurihara; Makoto Ikeya

  SSRN Electronic Journal, 2020

  
• Development of cell therapy for muscular dystrophy by iPSC-derived muscle stem cell

  Sakurai Hidetoshi; Zhao Mingming; Takenaka Nana; Sato Masae; Takayama Satoru; Tazumi Atsutoshi; Ikeya Makoto; Hotta Akitsu; Ito Yuta; Sekiguchi Kiyotoshi

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019

  
• ヒトiPS細胞由来間葉系間質細胞(MSC)は骨格筋疾患治療に応用可能であるか

  竹中 菜々; 金森 洋子; 池谷 真; 櫻井 英俊

  日本基礎理学療法学雑誌, Jan. 2016

  
• ヒトiPS細胞から作製された間葉系前駆細胞を利用した骨格筋疾患治療

  竹中 菜々; 金森 洋子; 池谷 真; 櫻井 英俊

  理学療法学, Apr. 2015

  
• iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.

  Pan Gao; Yoshiko Inada; Akitsu Hotta; Hidetoshi Sakurai; Makoto Ikeya

  Stem cell research & therapy, 18 Mar. 2024

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• Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges.

  Pan Gao; Mikihito Kajiya; Souta Motoike; Makoto Ikeya; Jingmei Yang

  The Japanese dental science review, Dec. 2024

  
• 末梢神経損傷における再生医療 Bio 3D printerを用いた人工神経

  池口 良輔; 青山 朋樹; 野口 貴志; 安藤 麻紀; 吉元 孝一; 坂本 大地; 岩井 輝修; 西谷 江平; 宮崎 雄大; 秋枝 静香; 池谷 真; 中山 功一; 松田 秀一

  末梢神経, Dec. 2022

  
• Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells

  Keisuke Mizuno; Hiroe Ohnishi; Masayoshi Yoshimatsu; Chengzhu Zhao; Yasuyuki Hayashi; Fumihiko Kuwata; Shinji Kaba; Hideaki Okuyama; Yoshitaka Kawai; Nao Hiwatashi; Yo Kishimoto; Tatsunori Sakamoto; Makoto Ikeya; Koichi Omori

  Cell Transplantation, Jan. 2023

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• 末梢神経損傷における再生医療 Bio 3D printerを用いた人工神経

  池口 良輔; 青山 朋樹; 野口 貴志; 安藤 麻紀; 吉元 孝一; 坂本 大地; 岩井 輝修; 西谷 江平; 宮崎 雄大; 秋枝 静香; 池谷 真; 中山 功一; 松田 秀一

  末梢神経, Dec. 2022

  
• Nerve regeneration using the Bio 3D nerve conduit fabricated with spheroids.

  Ryosuke Ikeguchi; Tomoki Aoyama; Mai Tanaka; Takashi Noguchi; Maki Ando; Koichi Yoshimoto; Daichi Sakamoto; Terunobu Iwai; Yudai Miyazaki; Shizuka Akieda; Makoto Ikeya; Koichi Nakayama; Shuichi Matsuda

  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, Dec. 2022

  
• Generation of a human SOX10 knock-in reporter iPSC line for visualization of neural crest cell differentiation.

  Teruyoshi Yamashita; Daisuke Kamiya; Nami Kawaraichi; Harufu Toyokawa; Teppei Akaboshi; Makoto Ikeya; Yayoi Toyooka

  Stem cell research, Apr. 2022

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• Generation of human GAPDH knock-in reporter iPSC lines for stable expression of tdTomato in pluripotent and differentiated culture conditions.

  Daisuke Kamiya; Teruyoshi Yamashita; Teppei Akaboshi; Yoshiki Yamaguchi; Yayoi Toyooka; Makoto Ikeya

  Stem cell research, Apr. 2022

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• Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification

  Ziadoon Al-Akashi; Denise Zujur; Daisuke Kamiya; Tomohisa Kato; Toru Kondo; Makoto Ikeya

  Frontiers in Cell and Developmental Biology, 06 Feb. 2023

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• ヒト多能性幹細胞から神経堤細胞への分化誘導法の開発

  田中 寛; 中井 義典; 福田 誠; 上野 盛夫; 池谷 真; 戸口田 淳也; 木下 茂

  日本眼科学会雑誌, Mar. 2014, Peer-reviewed

  
• Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage

  Daisuke Kamiya; Nana Takenaka-Ninagawa; Souta Motoike; Mikihito Kajiya; Teppei Akaboshi; Chengzhu Zhao; Mitsuaki Shibata; Sho Senda; Yayoi Toyooka; Hidetoshi Sakurai; Hidemi Kurihara; Makoto Ikeya

  npj Regenerative Medicine, 15 Sep. 2022

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• Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice

  Aya Harada; Megumi Goto; Atsuya Kato; Nana Takenaka-Ninagawa; Akito Tanaka; Satoru Noguchi; Makoto Ikeya; Hidetoshi Sakurai

  Frontiers in Cell and Developmental Biology, 23 Nov. 2021

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• Species-specific oscillation periods of human and mouse segmentation clocks are due to cell autonomous differences in biochemical reaction parameters

  Mitsuhiro Matsuda; Hanako Hayashi; Jordi Garcia-Ojalvo; Kumiko Yoshioka-Kobayashi; Ryoichiro Kageyama; Yoshihiro Yamanaka; Makoto Ikeya; Junya Toguchida; Cantas Alev; Miki Ebisuya

  bioRxiv, May 2019

  
• ヒトiPS細胞から作製された間葉系前駆細胞を利用した骨格筋疾患治療

  竹中 菜々; 金森 洋子; 池谷 真; 櫻井 英俊

  理学療法学Supplement, 2015

  
• Collagen-VI supplementation by cell transplantation improves muscle regeneration in Ullrich congenital muscular dystrophy model mice

  Nana Takenaka-Ninagawa; Jinsol Kim; Mingming Zhao; Masae Sato; Tatsuya Jonouchi; Megumi Goto; Clémence Kiho Bourgeois Yoshioka; Rukia Ikeda; Aya Harada; Takahiko Sato; Makoto Ikeya; Akiyoshi Uezumi; Masashi Nakatani; Satoru Noguchi; Hidetoshi Sakurai

  Stem Cell Research & Therapy, Dec. 2021

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• Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture.

  Taiki Nakajima; Akihiro Nakahata; Naoki Yamada; Keiko Yoshizawa; Tomoaki M Kato; Mio Iwasaki; Chengzhu Zhao; Hiroshi Kuroki; Makoto Ikeya

  Nature communications, 18 Aug. 2021

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• Bio-3D printing iPSCs-derived human chondrocytes for articular cartilage regeneration

  Anna Nakamura; Daiki Murata; Ryota Fujimoto; Sakura Tamaki; Sanae Nagata; Makoto Ikeya; Junya Toguchida; Koichi Nakayama

  Biofabrication, 11 Aug. 2021

  
• In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells.

  Masayoshi Yoshimatsu; Hiroe Ohnishi; Chengzhu Zhao; Yasuyuki Hayashi; Fumihiko Kuwata; Shinji Kaba; Hideaki Okuyama; Yoshitaka Kawai; Nao Hiwatashi; Yo Kishimoto; Tatsunori Sakamoto; Makoto Ikeya; Koichi Omori

  Stem cell research, Apr. 2021, Peer-reviewed

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• Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva.

  Francesc Ventura; Eleanor Williams; Makoto Ikeya; Alex N Bullock; Peter Ten Dijke; Marie-José Goumans; Gonzalo Sanchez-Duffhues

  Biomedicines, 19 Feb. 2021, Peer-reviewed

  
• Pluripotent stem cells in developmental biology (part 2).

  Makoto Ikeya; Yayoi Toyooka; Mototsugu Eiraku

  Development, growth & differentiation, Feb. 2021

  
• Pluripotent stem cells in developmental biology.

  Makoto Ikeya; Yayoi Toyooka; Mototsugu Eiraku

  Development, growth & differentiation, Jan. 2021

  
• Development of pluripotent stem cell-based human tenocytes.

  Taiki Nakajima; Makoto Ikeya

  Development, growth & differentiation, Jan. 2021, Peer-reviewed, Last author, Corresponding author

  
• ヒトiPS細胞由来間葉系間質細胞による6型コラーゲン補充は、ウルリッヒ型筋ジストロフィー(UCMD)モデルマウスの筋再生不全を改善する

  竹中 菜々; Kim Jin Sol; 趙 明明; 佐藤 優江; 城之内 達也; 後藤 萌; 吉岡クレモンス 紀穂; 池田 留輝愛; 池谷 真; 上住 聡芳; 佐藤 貴彦; 野口 悟; 櫻井 英俊

  日本筋学会学術集会プログラム・抄録集, Dec. 2020

  
• Olfactomedin-like 3 promotes PDGF-dependent pericyte proliferation and migration during embryonic blood vessel formation.

  Beat A Imhof; Romain Ballet; Philippe Hammel; Stéphane Jemelin; Sarah Garrido-Urbani; Makoto Ikeya; Thomas Matthes; Marijana Miljkovic-Licina

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Nov. 2020, Peer-reviewed

  
• Species-specific segmentation clock periods are due to differential biochemical reaction speeds.

  Mitsuhiro Matsuda; Hanako Hayashi; Jordi Garcia-Ojalvo; Kumiko Yoshioka-Kobayashi; Ryoichiro Kageyama; Yoshihiro Yamanaka; Makoto Ikeya; Junya Toguchida; Cantas Alev; Miki Ebisuya

  Science (New York, N.Y.), 18 Sep. 2020, Peer-reviewed

  
• Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration.

  Sadaki Mitsuzawa; Chengzhu Zhao; Ryosuke Ikeguchi; Tomoki Aoyama; Daisuke Kamiya; Maki Ando; Hisataka Takeuchi; Shizuka Akieda; Koichi Nakayama; Shuichi Matsuda; Makoto Ikeya

  Scientific reports, 21 Jul. 2020, Peer-reviewed

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• Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model.

  Mingming Zhao; Atsutoshi Tazumi; Satoru Takayama; Nana Takenaka-Ninagawa; Minas Nalbandian; Miki Nagai; Yumi Nakamura; Masanori Nakasa; Akira Watanabe; Makoto Ikeya; Akitsu Hotta; Yuta Ito; Takahiko Sato; Hidetoshi Sakurai

  Stem cell reports, 14 Jul. 2020, Peer-reviewed

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• A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells.

  Hiraku Tsujimoto; Tomoko Kasahara; Shin-Ichi Sueta; Toshikazu Araoka; Satoko Sakamoto; Chihiro Okada; Shin-Ichi Mae; Taiki Nakajima; Natsumi Okamoto; Daisuke Taura; Makoto Nasu; Tatsuya Shimizu; Makoto Ryosaka; Zhongwei Li; Masakatsu Sone; Makoto Ikeya; Akira Watanabe; Kenji Osafune

  Cell reports, 07 Apr. 2020, Peer-reviewed

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• ラット四肢移植モデルに対するヒトiPS細胞由来間葉系幹細胞の免疫抑制効果の検討

  光澤 定己; 池口 良輔; 青山 朋樹; 安藤 麻紀; 竹内 久貴; 野口 貴志; 太田 壮一; 趙 成珠; 池谷 真; 松田 秀一

  日本手外科学会雑誌, Apr. 2020

  
• ヒトiPS細胞由来間葉系幹細胞から作成したBio 3D conduitを用いた末梢神経の再生

  光澤 定己; 池口 良輔; 青山 朋樹; 安藤 麻紀; 竹内 久貴; 野口 貴志; 太田 壮一; 趙 成珠; 池谷 真; 松田 秀一

  日本手外科学会雑誌, Apr. 2020

  
• Recapitulating the human segmentation clock with pluripotent stem cells.

  Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Thomas L Maurissen; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Noriaki Kawakami; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev

  Nature, Apr. 2020, Peer-reviewed

  
• Insights into the biology of fibrodysplasia ossificans progressiva using patient-derived induced pluripotent stem cells.

  Taiki Nakajima; Makoto Ikeya

  Regenerative therapy, Dec. 2019, Peer-reviewed

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• Induced pluripotent stem cell-derived mesenchymal stem cells prolong hind limb survival in a rat vascularized composite allotransplantation model.

  Sadaki Mitsuzawa; Ryosuke Ikeguchi; Tomoki Aoyama; Maki Ando; Hisataka Takeuchi; Hirofumi Yurie; Hiroki Oda; Takashi Noguchi; Souichi Ohta; Chengzhu Zhao; Makoto Ikeya; Shuichi Matsuda

  Microsurgery, Nov. 2019, Peer-reviewed

  
• Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis.

  Souta Motoike; Mikihito Kajiya; Nao Komatsu; Susumu Horikoshi; Tomoya Ogawa; Hisakatsu Sone; Shinji Matsuda; Kazuhisa Ouhara; Tomoyuki Iwata; Noriyoshi Mizuno; Tsuyoshi Fujita; Makoto Ikeya; Hidemi Kurihara

  International journal of molecular sciences, 15 Aug. 2019, Peer-reviewed

  
• In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes.

  Shunsuke Kawai; Hiroyuki Yoshitomi; Junko Sunaga; Cantas Alev; Sanae Nagata; Megumi Nishio; Masataka Hada; Yuko Koyama; Maya Uemura; Kazuya Sekiguchi; Hirotsugu Maekawa; Makoto Ikeya; Sakura Tamaki; Yonghui Jin; Yuki Harada; Kenichi Fukiage; Taiji Adachi; Shuichi Matsuda; Junya Toguchida

  Nature biomedical engineering, Jul. 2019, Peer-reviewed

  
• TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing.

  Tatsuya Katsuno; Inna A Belyantseva; Alexander X Cartagena-Rivera; Keisuke Ohta; Shawn M Crump; Ronald S Petralia; Kazuya Ono; Risa Tona; Ayesha Imtiaz; Atteeq Rehman; Hiroshi Kiyonari; Mari Kaneko; Ya-Xian Wang; Takaya Abe; Makoto Ikeya; Cristina Fenollar-Ferrer; Gavin P Riordan; Elisabeth A Wilson; Tracy S Fitzgerald; Kohei Segawa; Koichi Omori; Juichi Ito; Gregory I Frolenkov; Thomas B Friedman; Shin-Ichiro Kitajiri

  JCI insight, 20 Jun. 2019, Peer-reviewed

  
• In Vitro Generation of Somite Derivatives from Human Induced Pluripotent Stem Cells.

  Taiki Nakajima; Hidetoshi Sakurai; Makoto Ikeya

  Journal of visualized experiments : JoVE, 25 Apr. 2019, Peer-reviewed

  
• Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells.

  Misato Iwashita; Hatsumi Ohta; Takahiro Fujisawa; Minyoung Cho; Makoto Ikeya; Satoru Kidoaki; Yoichi Kosodo

  Scientific reports, 28 Feb. 2019, Peer-reviewed

  
• Modeling the Human Segmentation Clock with Pluripotent Stem Cells

  Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K. Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev

  bioRxiv, Feb. 2019

  
• An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva.

  Kyosuke Hino; Chengzhu Zhao; Kazuhiko Horigome; Megumi Nishio; Yasue Okanishi; Sanae Nagata; Shingo Komura; Yasuhiro Yamada; Junya Toguchida; Akira Ohta; Makoto Ikeya

  Stem cell reports, 13 Nov. 2018, Peer-reviewed

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• Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells.

  Taiki Nakajima; Mitsuaki Shibata; Megumi Nishio; Sanae Nagata; Cantas Alev; Hidetoshi Sakurai; Junya Toguchida; Makoto Ikeya

  Development (Cambridge, England), 23 Aug. 2018, Peer-reviewed

  
• Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells.

  Chengzhu Zhao; Makoto Ikeya

  Stem cells international, 2018, Peer-reviewed

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• Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.

  Kyosuke Hino; Kazuhiko Horigome; Megumi Nishio; Shingo Komura; Sanae Nagata; Chengzhu Zhao; Yonghui Jin; Koichi Kawakami; Yasuhiro Yamada; Akira Ohta; Junya Toguchida; Makoto Ikeya

  The Journal of clinical investigation, 01 Sep. 2017, Peer-reviewed

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• Enhanced mTOR signaling triggered by Activin-A in chondrogenesis of fibrodysplasia ossificans progressiva (FOP)

  Hino K; Horigome K; Nishio M; Komura S; Nagata S; Zhao C; Jin Y; Kawakami K; Yamada Y; Ohta A; Toguchida J; Ikeya M

  J Clin Invest, Jul. 2017, Peer-reviewed

  
• SOX10-Nano-Lantern Reporter Human iPS Cells; A Versatile Tool for Neural Crest Research.

  Tomoko Horikiri; Hiromi Ohi; Mitsuaki Shibata; Makoto Ikeya; Morio Ueno; Chie Sotozono; Shigeru Kinoshita; Takahiko Sato

  PloS one, 2017, Peer-reviewed

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• Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair.

  Ryota Chijimatsu; Makoto Ikeya; Yukihiko Yasui; Yasutoshi Ikeda; Kosuke Ebina; Yu Moriguchi; Kazunori Shimomura; David A Hart; Yoshikawa Hideki; Nakamura Norimasa

  Stem cells international, 2017, Peer-reviewed

  
• BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.

  Yohei Hayashi; Edward C Hsiao; Salma Sami; Mariselle Lancero; Christopher R Schlieve; Trieu Nguyen; Koyori Yano; Ayako Nagahashi; Makoto Ikeya; Yoshihisa Matsumoto; Ken Nishimura; Aya Fukuda; Koji Hisatake; Kiichiro Tomoda; Isao Asaka; Junya Toguchida; Bruce R Conklin; Shinya Yamanaka

  Proceedings of the National Academy of Sciences of the United States of America, 15 Nov. 2016, Peer-reviewed

  
• Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives.

  Fabian Oceguera-Yanez; Shin-Il Kim; Tomoko Matsumoto; Ghee Wan Tan; Long Xiang; Takeshi Hatani; Takayuki Kondo; Makoto Ikeya; Yoshinori Yoshida; Haruhisa Inoue; Knut Woltjen

  Methods (San Diego, Calif.), 15 May 2016, Peer-reviewed

  
• [Application of disease-specific iPS cells for intractable diseases-from pathomechanisms to drug discovery].

  Junya Toguchida; Kyosuke Hino; Makoto Ikeya

  Clinical calcium, Apr. 2016, Peer-reviewed

  
• Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

  Kyosuke Hino; Makoto Ikeya; Kazuhiko Horigome; Yoshihisa Matsumoto; Hayao Ebise; Megumi Nishio; Kazuya Sekiguchi; Mitsuaki Shibata; Sanae Nagata; Shuichi Matsuda; Junya Toguchida

  Proceedings of the National Academy of Sciences of the United States of America, 15 Dec. 2015, Peer-reviewed

  
• Application of patients - derived iPS cells for intractable musculoskeletal diseases.

  Junya Toguchida; Koji Yokoyama; Makoto Ikeya; Toshio Heike

  Nihon rinsho. Japanese journal of clinical medicine, Jun. 2015, Peer-reviewed

  
• New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva.

  Yoshihisa Matsumoto; Makoto Ikeya; Kyosuke Hino; Kazuhiko Horigome; Makoto Fukuta; Makoto Watanabe; Sanae Nagata; Takuya Yamamoto; Takanobu Otsuka; Junya Toguchida

  Stem cells (Dayton, Ohio), Jun. 2015, Peer-reviewed

  
• SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier.

  Sakura Tamaki; Makoto Fukuta; Kazuya Sekiguchi; Yonghui Jin; Sanae Nagata; Kazuo Hayakawa; Sho Hineno; Takeshi Okamoto; Makoto Watanabe; Knut Woltjen; Makoto Ikeya; Tomohisa Kato Jr; Junya Toguchida

  PloS one, 2015, Peer-reviewed

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• Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.

  Yonghui Jin; Hassan Elalaf; Makoto Watanabe; Sakura Tamaki; Sho Hineno; Kazuhito Matsunaga; Knut Woltjen; Yukiko Kobayashi; Sanae Nagata; Makoto Ikeya; Tomohisa Kato Jr; Takeshi Okamoto; Shuichi Matsuda; Junya Toguchida

  PloS one, 2015, Peer-reviewed

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• Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.

  Koji Yokoyama; Makoto Ikeya; Katsutsugu Umeda; Hirotsugu Oda; Seishiro Nodomi; Akira Nasu; Yoshihisa Matsumoto; Kazushi Izawa; Kazuhiko Horigome; Toshimasa Kusaka; Takayuki Tanaka; Megumu K Saito; Takahiro Yasumi; Ryuta Nishikomori; Osamu Ohara; Naoki Nakayama; Tatsutoshi Nakahata; Toshio Heike; Junya Toguchida

  Arthritis & rheumatology (Hoboken, N.J.), Jan. 2015, Peer-reviewed

  
• Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media.

  Makoto Fukuta; Yoshinori Nakai; Kosuke Kirino; Masato Nakagawa; Kazuya Sekiguchi; Sanae Nagata; Yoshihisa Matsumoto; Takuya Yamamoto; Katsutsugu Umeda; Toshio Heike; Naoki Okumura; Noriko Koizumi; Takahiko Sato; Tatsutoshi Nakahata; Megumu Saito; Takanobu Otsuka; Shigeru Kinoshita; Morio Ueno; Makoto Ikeya; Junya Toguchida

  PloS one, 2014, Peer-reviewed

  
• Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.

  Yoshihisa Matsumoto; Yohei Hayashi; Christopher R Schlieve; Makoto Ikeya; Hannah Kim; Trieu D Nguyen; Salma Sami; Shiro Baba; Emilie Barruet; Akira Nasu; Isao Asaka; Takanobu Otsuka; Shinya Yamanaka; Bruce R Conklin; Junya Toguchida; Edward C Hsiao

  Orphanet journal of rare diseases, 09 Dec. 2013, Peer-reviewed

  
• iPS細胞技術を用いた滑膜肉腫起源の同定への試み

  福田 誠; 早川 和男; 玉置 さくら; 佐藤 信吾; 池谷 真; 大塚 隆信; Woltjen Knut; 戸口田 淳也

  日本整形外科学会雑誌, Aug. 2013

  
• 骨・軟部腫瘍の発生機構 多能性幹細胞を用いた融合癌蛋白標的遺伝子の同定

  早川 和男; 池谷 真; 福田 誠; ウォルテン・クヌート; 玉置 さくら; 高原 直子; 松本 佳久; 佐藤 信吾; 大塚 隆信; 戸口田 淳也

  日本整形外科学会雑誌, Jun. 2013

  
• Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells.

  Kazuo Hayakawa; Makoto Ikeya; Makoto Fukuta; Knut Woltjen; Sakura Tamaki; Naoko Takahara; Tomohisa Kato Jr; Shingo Sato; Takanobu Otsuka; Junya Toguchida

  Biochemical and biophysical research communications, 22 Mar. 2013, Peer-reviewed

  
• Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin.

  Akira Nasu; Makoto Ikeya; Takuya Yamamoto; Akira Watanabe; Yonghui Jin; Yoshihisa Matsumoto; Kazuo Hayakawa; Naoki Amano; Shingo Sato; Kenji Osafune; Tomoki Aoyama; Takashi Nakamura; Tomohisa Kato; Junya Toguchida

  PloS one, 2013, Peer-reviewed

  
• Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro.

  Akihito Tanaka; Knut Woltjen; Katsuya Miyake; Akitsu Hotta; Makoto Ikeya; Takuya Yamamoto; Tokiko Nishino; Emi Shoji; Atsuko Sehara-Fujisawa; Yasuko Manabe; Nobuharu Fujii; Kazunori Hanaoka; Takumi Era; Satoshi Yamashita; Ken-Ichi Isobe; En Kimura; Hidetoshi Sakurai

  PloS one, 2013, Peer-reviewed

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• Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.

  Makoto Ikeya; Kumi Fukushima; Masako Kawada; Sachiko Onishi; Yasuhide Furuta; Shigenobu Yonemura; Toshio Kitamura; Tetsuya Nosaka; Yoshiki Sasai

  Developmental biology, 15 Jan. 2010, Peer-reviewed

  
• Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice

  Makoto Ikeya; Tetsuya Nosaka; Kumi Fukushima; Masako Kawada; Yasuhide Furuta; Toshio Kitamura; Yoshilzi Sasai

  MECHANISMS OF DEVELOPMENT, Sep. 2008, Peer-reviewed

  
• The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo.

  Akiko Arakawa; Mami Matsuo-Takasaki; Akira Takai; Hidehiko Inomata; Michiru Matsumura; Makoto Ikeya; Kenzo Takahashi; Yoshiki Miyachi; Noriaki Sasai; Yoshiki Sasai

  Developmental biology, 01 Jun. 2007, Peer-reviewed

  
• Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.

  Makoto Ikeya; Masako Kawada; Hiroshi Kiyonari; Noriaki Sasai; Kazuki Nakao; Yasuhide Furuta; Yoshiki Sasai

  Development (Cambridge, England), Nov. 2006, Peer-reviewed

  
• Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors.

  Makoto Sakuragi; Noriaki Sasai; Makoto Ikeya; Masako Kawada; Takayuki Onai; Tatsuya Katahira; Harukazu Nakamura; Yoshiki Sasai

  Mechanisms of development, Feb. 2006, Peer-reviewed

  
• Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations.

  Makoto Ikeya; Masako Kawada; Yoko Nakazawa; Makoto Sakuragi; Noriaki Sasai; Morio Ueno; Hiroshi Kiyonari; Kazuki Nakao; Yoshiki Sasai

  The International journal of developmental biology, 2005, Peer-reviewed

  
• Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord.

  Yuko Muroyama; Motoyuki Fujihara; Makoto Ikeya; Hisato Kondoh; Shinji Takada

  Genes & development, 01 Mar. 2002, Peer-reviewed

  
• Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.

  M Nomi; I Oishi; S Kani; H Suzuki; T Matsuda; A Yoda; M Kitamura; K Itoh; S Takeuchi; K Takeda; S Akira; M Ikeya; S Takada; Y Minami

  Molecular and cellular biology, Dec. 2001, Peer-reviewed

  
• Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal.

  T Kawauchi; M Ikeya; S Takada; K Ueda; M Shirai; Y Takihara; N Kioka; T Amachi

  Mechanisms of development, Aug. 2001, Peer-reviewed

  
• Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.

  T Matsuda; M Nomi; M Ikeya; S Kani; I Oishi; T Terashima; S Takada; Y Minami

  Mechanisms of development, Jul. 2001, Peer-reviewed

  
• Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression.

  M Ikeya; S Takada

  Mechanisms of development, May 2001, Peer-reviewed

  
• Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation.

  S Takeuchi; K Takeda; I Oishi; M Nomi; M Ikeya; K Itoh; S Tamura; T Ueda; T Hatta; H Otani; T Terashima; S Takada; H Yamamura; S Akira; Y Minami

  Genes to cells : devoted to molecular & cellular mechanisms, Jan. 2000, Peer-reviewed

  
• [Roles of Wnt signals secreted from the developing neural tube].

  S Takada; M Ikeya

  Seikagaku. The Journal of Japanese Biochemical Society, Oct. 1999, Peer-reviewed

  
• The roles of Wnt signaling in the developing dorsal neural tube

  M Ikeya; SMK Lee; AP McMahon; S Takada

  NEURAL DEVELOPMENT-BOOK, 1999, Peer-reviewed

  
• Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.

  M Ikeya; S Takada

  Development (Cambridge, England), Dec. 1998, Peer-reviewed

  
• Wnt signalling required for expansion of neural crest and CNS progenitors.

  M Ikeya; S M Lee; J E Johnson; A P McMahon; S Takada

  Nature, 30 Oct. 1997, Peer-reviewed

  

Misc.

• 新規mTOR signaling modulatorはFOPにおける異所性骨化を抑制する

  日野恭介; 日野恭介; 趙成珠; 堀込一彦; 堀込一彦; 西尾恵; 岡西泰永; 永田早苗; 河村真吾; 河村真吾; 山田泰広; 戸口田淳也; 戸口田淳也; 戸口田淳也; 戸口田淳也; 太田章; 池谷真

  日本再生医療学会総会(Web), 2019

  
• Peripheral nerve regeneration using Bio 3D printer.

  池口良輔; 池口良輔; 青山朋樹; 野口貴志; 安藤麻紀; 吉元孝一; 坂本大地; 宮崎雄大; 秋枝静香; 池谷真; 中山功一; 松田秀一; 松田秀一

  末梢神経, 2022

  
• 「iPS創薬×ドラッグリポジショニング」による進行性骨化性線維異形成症の治療薬開発

  中島 大輝; 池谷 真

  ファルマシア, Mar. 2019

  
• 患者由来iPS細胞を用いた進行性骨化性線維異形成症(FOP)の病態解明

  日野 恭介; 堀込 一彦; 池田 篤史; 海老瀬 速雄; 池谷 真; 戸口田 淳也

  住友化学 : 技術誌, 2017

  
• 脊椎動物の原腸形成期におけるWntシグナルの役割 (特集 Wntシグナルと形態形成)

  池谷 真; 高田 慎治

  細胞工学, Nov. 2000

  
• 罹患者由来iPS細胞を用いたCINCA症候群における関節病態の解明

  横山 宏司; 西小森 隆太; 納富 誠司郎; 田中 孝之; 斎藤 潤; 梅田 雄嗣; 池谷 真; 中畑 龍俊; 戸口田 淳也; 平家 俊男

  日本小児科学会雑誌, Feb. 2014

  
• 罹患者由来iPS細胞を用いたCINCA症候群における関節病態の解明

  横山 宏司; 池谷 真; 那須 輝; 田中 孝之; 斎藤 潤; 梅田 勝嗣; 西小森 隆太; 中畑 龍俊; 平家 俊男; 戸口田 淳也

  日本整形外科学会雑誌, Aug. 2013

  
• Application of iPS cells for rare and intractable bone and cartilage diseases

  松本 佳久; 池谷 真; 横山 宏司

  日本整形外科学会雑誌, Dec. 2015

  
• Application of patients-derived iPS cells for in vitro recapitulation of pathologic condition : Bone and cartilage diseases

  戸口田 淳也; 池谷 真

  医学のあゆみ, 21 Mar. 2015

  
• Recent Advances in the Field of Mesenchymal Stem Cells

  戸口田 淳也; 福田 誠; 池谷 真

  細胞工学, 2014

  
• ヒトiPS細胞由来間葉系間質細胞による6型コラーゲン補充は,ウルリッヒ型筋ジストロフィー(UCMD)モデルマウスの筋再生不全を改善する

  竹中菜々; KIM Jin Sol; 趙明明; 佐藤優江; 城之内達也; 後藤萌; 吉岡クレモンス紀穂; 池田留輝愛; 池谷真; 上住聡芳; 佐藤貴彦; 野口悟; 櫻井英俊

  日本筋学会学術集会プログラム・抄録集, 2020

  
• iPS細胞由来間葉系幹細胞から構築した三次元神経導管による末梢神経再生

  趙成珠; 光澤定己; 淘江宏文; 加治屋幹人; 山田尚基; 田中麻衣; 秋枝静香; 中山功一; 栗原英見; 松田秀一; 青山朋樹; 池口良輔; 池谷真

  日本再生医療学会総会(Web), 2019

  
• Peripheral nerve regeneration in a rat crushed sciatic nerve model: Using a Bio 3D sheets generated from human iPSC-derived mesenchymal stromal cells

  Naoki Yamada; Chengzhu Zhao; Akira Ito; Tianshu Wang; Akihiro Nakahata; Nan Liang; Taiki Nakajima; Mai Tanaka; Shizuka Akieda; Koichi Nakayama; Masahiro Abo; Tomoki Aoyama; Makoto Ikeya

  2019, Peer-reviewed

  
• ヒトiPS細胞由来骨格筋幹細胞を用いた筋ジストロフィーに対する細胞移植治療

  櫻井英俊; 田積充年; 田積充年; 高山了; 高山了; 竹中菜々; 趙明明; 佐藤優江; 池谷真; 堀田秋津; 佐藤貴彦; 伊東佑太; 関口清俊

  日本筋学会学術集会プログラム・抄録集, Aug. 2018

  
• 運動器疾患の病態理解から治療法へ〜iPS細胞技術を中心に〜 ヒトiPS細胞由来骨格筋幹細胞を用いた筋ジストロフィーに対する細胞移植治療

  櫻井 英俊; 田積 充年; 高山 了; 竹中 菜々; 趙 明明; 佐藤 優江; 池谷 真; 堀田 秋津; 佐藤 貴彦; 伊東 佑太; 関口 清俊

  日本筋学会学術集会プログラム・抄録集, Aug. 2018

  
• ヒトiPS細胞由来間葉系間質細胞を用いたウルリッヒ型筋ジストロフィー症に対する細胞移植治療研究

  竹中菜々; KIM Jinsol; 池谷真; 堀田秋津; 上住聡芳; 佐藤貴彦; 野口悟; 櫻井英俊

  日本再生医療学会総会(Web), 2018

  
• iPS細胞を用いた筋ジストロフィーに対する細胞移植治療法の開発

  櫻井英俊; 趙明明; 高山了; 竹中菜々; 田積充年; 佐藤優江; 池谷真; 堀田秋津; 佐藤貴彦; 伊東佑太; 関口清俊

  日本再生医療学会総会(Web), 2018

  
• 筋生物学の統合的理解にむけた新たな潮流 iPS細胞からの骨格筋幹細胞誘導と、筋ジストロフィーに対する再生医療への応用

  櫻井 英俊; 高山 了; 田積 充年; 竹中 菜々[蜷川]; 趙 明明; 池谷 真; 堀田 秋津; 佐藤 貴彦; 伊東 佑太

  生命科学系学会合同年次大会, Dec. 2017

  
• ヒトiPS細胞由来間葉系前駆細胞(iMSC)を用いたウルリッヒ型筋ジストロフィー症に対する細胞治療法の開発

  竹中菜々; KIM Jin Sol; 伊東佑太; 上住聡芳; 池谷真; 野口悟; 櫻井英俊

  日本筋学会学術集会プログラム・抄録集, 03 Jul. 2017

  
• iPS細胞を用いた筋ジストロフィーに対する細胞移植治療法の開発

  櫻井英俊; 高山了; 竹中菜々; 竹中菜々; 趙明明; 田積充年; 田積充年; 池谷真; 堀田秋津; 伊東佑太; 佐藤貴彦

  再生医療, 01 Feb. 2017

  
• ヒトiPS細胞由来間葉系間質細胞(MSC)は骨格筋疾患治療に応用可能であるか

  竹中菜々; 竹中菜々; 池谷真; 櫻井英俊; 野口悟; 上住聡芳

  再生医療, 2017

  
• 家族性OPLL患者由来のiPS細胞を用いたOPLL遺伝的要素の検討

  川井 俊介; 羽田 匡孝; 小山 優子; 池谷 真; Alev Cantas; 堀田 秋津; 池川 志郎; 中村 雅也; 松本 守雄; 吉富 啓之; 松田 秀一; 戸口田 淳也

  日本整形外科学会雑誌, Aug. 2016

  
• iPS細胞を用いた運動器疾患治療への挑戦 疾患特異的iPS細胞を活用した骨格系疾患の病態解明・創薬

  戸口田 淳也; 日野 恭介; 池谷 真; 関口 和也; 金 永輝; 岡本 健; 吉富 啓之; 松田 秀一

  日本整形外科学会雑誌, Aug. 2016

  
• 運動器再生医療の最前線 iPS細胞からの骨細胞系譜への誘導と応用

  戸口田 淳也; 川井 俊介; 日野 恭介; 池谷 真; アレブ・ジャンタッシュ; 吉富 啓之; 松田 秀一

  日本骨代謝学会学術集会プログラム抄録集, Jul. 2016

  
• Modeling Charcot-Marie-Tooth disease using patient-induced pluripotent stem cells

  Morii F; Imamura K; Ohara R; Shibata M; Sekiguchi K; Ikeya M; Toguchida J; Mizuno T; Nakagawa M; Inoue H

  57th Annual Meeting of the Japanese Society of Neurology, Kobe., 18 May 2016

  
• Pathology analysis of fibrodysplasia ossificans progressiva utilizing iPS cells

  松本 佳久; 日野 恭介; 池谷 真; 戸口田 淳也

  バイオサイエンスとインダストリー, 2016

  
• Application of patients-derived iPS cells for intractable musculoskeletal diseases

  戸口田 淳也; 横山 宏司; 池谷 真; 平家 俊男; 西小森 隆太

  臨床免疫・アレルギー科, Aug. 2015

  
• 【再生医療-新たな医療を求めて-】 臨床応用を目指した基礎研究 疾患モデル細胞、iPS細胞を用いた毒性評価と創薬研究 疾患特異的iPS細胞を活用した筋骨格系難病研究

  戸口田 淳也; 横山 宏司; 池谷 真; 平家 俊男; 西小森 隆太

  日本臨床, Jun. 2015

  
• 【病理医を誘うiPS細胞を使った疾患研究】 疾患特異的iPS細胞を活用した骨軟骨疾患研究

  戸口田 淳也; 池谷 真; 西小森 隆太

  病理と臨床, Jun. 2015

  
• Modeling for hereditary neuropathy using patient-induced pluripotent stem cells

  Morii F; Ohara R; Imamura K; Shibata M; Sekiguchi K; Ikeya M; Toguchida J; Mizuno T; Nakagawa M; Inoue H

  56th Annual Meeting of the Japanese Society of Neurology, Niigata., 23 May 2015

  
• 骨系統疾患の現状と展望(研究、診断、そして治療) 疾患特異的iPS細胞を活用した難治性骨軟骨疾患の病態解明

  戸口田 淳也; 松本 佳久; 横山 宏司; 松田 秀一; 西小森 隆太; 池谷 真

  日本整形外科学会雑誌, Mar. 2015

  
• 【再生医療2015 幹細胞と疾患iPS細胞の研究最前線】 (第3章)疾患iPS細胞 疾患特異的iPS細胞を用いた難治性骨軟骨疾患の病態解析・創薬

  戸口田 淳也; 池谷 真; 西小森 隆太; 松本 佳久; 横山 宏司

  実験医学, Feb. 2015

  
• 疾患特異的iPS細胞を用いたCINCA症候群における成長軟骨病態の解析

  戸口田淳也; 横山宏司; 玉置さくら; 小山優子; 池谷真; 田中孝之; 斎藤潤; 梅田雄嗣; 中畑龍俊; 平家俊男; 西小森隆太

  再生医療, 01 Feb. 2015

  
• ヒト免疫とリウマチ性疾患 自己炎症性疾患とリウマチ疾患のcrossroad CINCA症候群/NOMIDの骨幹端過形成をとりあげて

  西小森 隆太; 横山 宏司; 梅田 雄嗣; 池谷 真; 中川 権史; 納富 誠司郎; 八角 高裕; 田中 孝之; 齋藤 潤; 小田 紘嗣; 小原 收; 中山 直樹; 戸口田 淳也; 平家 俊男

  日本リウマチ学会総会・学術集会プログラム・抄録集, Mar. 2014

  
• 骨・軟部腫瘍 希少疾患に光明をもたらす夢の実現へ 新規治療戦略の開発をめざした肉腫起源細胞の探索

  戸口田 淳也; 玉置 さくら; 福田 誠; 池谷 真; 加藤 友久; 岡本 健; 大塚 隆信; 松田 秀一

  日本整形外科学会雑誌, Mar. 2014

  
• Identification of Gene Sets Dysregulated by Mutant ACVR1 Gene Causing A Rare Intractable Disease, Fibrodysplasia Ossificance Progressiva.

  Yoshihisa Matsumoto; Makoto Ikeya; Takanobu Otsuka; Junya Toguchida

  JOURNAL OF BONE AND MINERAL RESEARCH, Feb. 2014

  
• 自己炎症性疾患における診療研究の新展開 "炎症"と小児発熱性疾患 疾患特異的iPS細胞を用いたCINCA/NOMIDにおける骨幹端過形成の機序解明

  西小森 隆太; 横山 宏司; 梅田 雄嗣; 池谷 真; 中川 権史; 納富 誠司郎; 八角 高裕; 田中 孝之; 斉藤 潤; 小田 紘嗣; 小原 収; 中山 直樹; 戸口田 淳也; 平家 俊男

  日本小児科学会雑誌, Feb. 2014

  
• 日本人の軟骨腫瘍におけるIDH遺伝子の突然変異スペクトラム(Mutation spectrum of IDH genes in Japanese cartilaginous tumors)

  金 永輝; Elalaf Hassan; 加藤 友久; 池谷 真; 永田 早苗; 仲俣 岳晴; 岡本 健; 松田 秀一; 戸口田 淳也

  日本癌学会総会記事, Oct. 2013

  
• iPS細胞の基礎と応用(第3回)iPS細胞を使う : 骨の研究へ

  松本 佳久; 福田 誠; 池谷 真

  整形外科 = Orthopedic surgery, Aug. 2013

  
• Induced pluripotent stem cells : present state and future perspectives for clinical applications

  池谷 真; 松本 佳久; 横山 宏司

  整形・災害外科, Apr. 2013

  
• Application of iPS cell technology \nfor the analysis of origin-unknown sarcoma characterized by a specific fusion gene．

  Hayakawa K; Fukuta M; TamaiS; Kato T; Ikeya M; Otsuka T; Woltjen K; Toguchida J

  第17 回CTOS （2012.11.16．Prague）, 16 Nov. 2012, Peer-reviewed

  
• BMP-SMAD-ID signaling axis supports reprogramming to pluripotency

  Y. Hayashi; E. C. Hsiao; S. Sami; M. Lancero; C. R. Schlieve; T. Nguyen; K. Yano; A. Nagahashi; M. Ikeya; Y. Matsumoto; I. Asaka; J. Toguchida; B. R. Conklin; S. Yamanaka

  MOLECULAR BIOLOGY OF THE CELL, 2012

  
• Proteomic analysis-based identification of proteins related \nto differentiation of human iPS cells into cartilage cells．

  Watanabe M; Nasu A; Kato T; Ikeya M; Toguchida J; Sato T

  第10 回ISSCR（2012.6.15．横浜）, 2012, Peer-reviewed

  
• Genetically matched human iPS cells revealed that the propensity for iPS cells to differentiate into cartilage lineage cells differs with clones, but not cell type of origin

  Nasu A; Kato T; Yamamoto T; Ikeya M; Toguchida J

  第10 回ISSCR（2012.6.15．横浜）, 2012, Peer-reviewed

  
• Understanding the pathology of the arthropathy in chronic infantile neurological cutaneous and articular \nsyndrome by using iPS cells technology

  Yokoyama K; Ikeya M; Nasu A; Tanaka T; Saito M; Umeda K; Nishikomori R; Nakahata T; Heike T; Toguchida J

  第10 回ISSCR（2012.6.15．横浜）, 2012, Peer-reviewed

  
• Establishment and functional \nanalysis of iPS cells with drug-inducible SYT-SSX fusion gene．

  Fukuta M; Hayakawa K; Tamaki S; Sato S; Ikeya M; Otsuka Y; Woltjen K; Toguchida J

  第10 回ISSCR（2012.6.14．横浜）, 2012, Peer-reviewed

  
• BMP-SMAD-ID axis promotes reprogramming to pluripotency．

  Hayashi Y; Hsiao E; Sami S; Lancero M; Schlieve C; Yano K; Nagahashi A; Ikeya M; Matsumoto Y; Asaka I; JToguchida J; Conckin B; Yamanaka S

  第10 回ISSCR（2012.6.14．横浜）, 2012, Peer-reviewed

  
• PS 細胞を用いた肉腫研究：滑膜肉腫の起源細胞の解明をめざして

  福田誠; 早川和男; 玉置さくら; 沖田圭介; 池谷真; Knut Woltjen; 大塚隆信; 戸口田淳也

  第27 回日本整形外科学会基礎学術集会（2012.10.26． 名古屋）, 2012, Peer-reviewed

  
• 人工多能性幹細胞を用いた希少難治性骨疾患への取り組み

  松本佳久; 池谷真; Edward Hsiao; 那須輝; 浅香勲; 大塚隆信; 戸口田淳也

  第27 回日本整形外科学会基礎学術集会（2012.10.26．名古屋）, 2012, Peer-reviewed

  
• 罹患者由来iPS 細部を用いたCINCA 症候群における関節病態の分子機構の解明

  横山宏司; 池谷真; 那須輝; 田中孝之; 斎藤潤; 梅田雄嗣; 西小森隆太; 中畑龍俊; 平家俊男; 戸口田淳也

  第27 回日本整形外科学会基礎学術集会（2012.10.26．名古屋）, 2012, Peer-reviewed

  
• イヌ体細胞由来人工多能性幹細胞の樹立

  早川和男; 加藤友久; 那須輝; 池谷真; 堀田秋津; 大塚隆信; 戸口田淳也

  第27 回日本整形外科学会基礎学術集会（2012.10.26．名古屋）, 2012, Peer-reviewed

  
• 肉腫の病態解明への幹細胞研究 の応用

  戸口田淳也; 玉置さくら; 早川和男; 福田誠; 高原直子; 池谷真; 加藤友久

  第71 回日本癌学会総会（2012.9.21．札幌）, 2012, Peer-reviewed

  
• 薬剤誘導型発現ベクターを用いたSYT-SSX 融合遺伝子導入iPS 細胞の樹立

  早川和男; 福田誠; 玉置さくら; 佐藤信吾; 池谷真; 大塚隆信; Knut Woltjen; 戸口田淳也

  第45 回日本整形外科学会骨軟部腫瘍学術 集会（2012.7.15．東京）, 2012, Peer-reviewed

  
• 同一ドナーの異なる組織より樹立したiPS 細胞の比較検討

  那須輝; 加藤友久; 山本拓也; 中村孝志; 池谷真; 戸口田淳也

  第11 回日本再生医療学会（2012.6.13．横浜）, 2012, Peer-reviewed

  
• iPS 細胞を用いたCINCA 症候群の関節病変の解析

  横山宏司; 池谷真; 那須輝; 田中孝之; 斎藤潤; 梅田雄嗣; 西小森隆太; 中畑龍俊; 平家俊男; 戸口田淳也

  第11 回日本再生医療学会（2012.6.13．横浜）, 2012, Peer-reviewed

  
• J．Generation of canine iPS cells and their \ncharcteristics

  Hayakawa K; Kato T; Nasu A; Ikeya M; Otsuka T; Toguchida J

  第9 回ISSCR（2011.6.17 Toronto）, 2011, Peer-reviewed

  
• iPS 細胞を用いた難治性骨疾患への取り組み

  松本佳久; 那須輝; 池谷真; 戸口田淳也

  京都大学再生医科学研究所学術講演会（2010.12.13 京都）, 2010, Peer-reviewed

  
• Essential pro-BMP roles of Crossveinless2 in mouse organogenesis

  Makoto Ikeya; Masako Kawada; Hiroshi Kiyonari; Noriaki Sasai; Kazuki Nakao; Yasuhide Furuta; Sasai

  DEVELOPMENTAL BIOLOGY, Jun. 2007

  

Books and Other Publications

• 連載iPS細胞の基礎と応用 第３回 iPS細胞を使うー骨の研究へ

  松本佳久; 福田誠; 池谷真; 戸口田淳也

  南江堂, 01 Aug. 2013, Not refereed

  
• iPS細胞ーその基礎と臨床応用に向けた展望ー

  池谷真; 松本佳久; 横山宏司; 戸口田淳也

  整形・災害外科 第56巻第5号、４月臨時増刊号、507-514、金原出版株式会社, 2013, Not refereed

  
• 難治性骨軟骨疾患罹患者由来iPS細胞を用いた病態再現と治療薬開発の試み

  松本佳久; 池谷 真; 戸口田淳也

  遺伝子医学MOOK 22号, 190-194, メディカルドゥ, 2012, Not refereed

  
• 最新疾患モデルと病態解明、創薬応用研究、細胞医薬創製研究の最前線

  戸口田淳也; 池谷 真

  メディカルドゥ, 2012, Not refereed

  Find Kyoto University's collection of books :

  

External funds: Kakenhi

• Establishment of induction protocols for a functional syndetome aiming to develop a novel treatment for tendon and ligament regeneration

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Kyoto University

  Makoto Ikeya

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  靭帯節細胞;靭帯再生;多能性幹細胞;再生医療;ヒトiPS細胞;靱帯節細胞;靱帯再生;靭帯;分化誘導

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03803/
• Development of periodontal tissue regenerative therapy by using neural crest-derived MSCs and cell clumps culture technique

  Grant-in-Aid for Scientific Research (B)

  Basic Section 57030:Conservative dentistry-related

  Hiroshima University

  Hidemi Kurihara

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  間葉系幹細胞集塊;C-MSCs;神経堤細胞由来間葉系幹細胞;iPS細胞;立体複合化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02977/
• Induction of tendon/ligament progenitor cells from human iPSCs

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  CANTAS ALEV

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  Tendon Progenitor Cell;iPSCs;Mesoderm Differentiation;tendon progenitor cells;mesoderm differentiation;syndetome;Tendon Progenitor Cells;iPS細胞;腱誘導;中胚葉誘導;スクレラキシス;リポーター細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15664/
• Identification of the cell-of-origin of ectopic bones using lineage tracing mice

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Makoto Ikeya

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  異所性骨化;細胞・組織;進行性骨化性線維異形成症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15662/
• Development of a xeno-free induction and maintenance protocol for MSCs from PSCs

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Makoto IKEYA

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  間葉系幹細胞;再生医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05447/
• Functional analyses of mutant NLRP3 on the growth and differentiation of growth plate chondrocytes

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Junya Toguchida

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  CINCA症候群;NLRP3;成長軟骨;iPS細胞;成長板軟骨細胞;細胞間相互作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15549/
• Investigation of functional roles of mutant IDH as specific mutations in cartilage-forming tumors and its application for the development of treatment

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Junya Toguchida

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  chondrosarcoma;IDH;iPSC;p16;IDH遺伝子;軟骨形成性腫瘍;iPS細胞;軟骨腫瘍;間葉系幹細胞;神経幹細胞;ヒストンメチル化;軟骨形成腫瘍

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04956/
• Derivation of human PSC-derived mesodermal cells

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Makoto Ikeya

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  中胚葉細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670661/
• Analysis of fibrodysplasia ossificans progressive by using iPSCs

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Makoto Ikeya

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  異所性骨化;進行性骨化性線維異形成症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293320/
• Establishment of canine iPS cells for the study of disease-model dogs

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Junya TOGUCHIDA

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  iPS細胞;イヌ;疾患モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659675/
• Investigation for the pathomechanism of cartilage-forming tumors by whole exome sequencing

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Junya TOGUCHIDA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  軟骨形成腫瘍;Maffucci症候群;iPS細胞;Ollier病;エクソーム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390353/
• Establishment of the assay system of drug screening for fibrodysplasia ossificans progressiva

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Makoto IKEYA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  進行性骨化症線維異形成症;進行性骨化性線維異形成症;異所性骨化;BMP受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791636/
• Functional analysis of BMP binding protein, Cv2, in nephorogenesis

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Makoto IKEYA

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  遺伝学;発生・分化;細胞・組織;シグナル伝達;循環器・高血圧

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770249/
• Development of periodontal tissue regenerative allograft cell therapy by using clumps of MSCs and chondrogenic induction

  Grant-in-Aid for Scientific Research (B)

  Basic Section 57040:Regenerative dentistry and dental engineering-related

  Hiroshima University

  加治屋 幹人

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  間葉系幹細胞集塊;神経堤細胞由来間葉系幹細胞;顎骨オルガノイド;歯肉オルガノイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03275/
• iPS細胞由来中胚葉系細胞を用いて新たな靭帯再建法の確立を目指す研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Saga University

  村田 大紀

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  靭帯組織体;靭帯再建;iPS細胞由来中胚葉系細胞;スキャフォールドフリー;細胞構造体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03204/
• 細胞系譜に着目したiPS細胞由来間葉系幹細胞の基盤的研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Kyoto University

  池谷 真

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  間葉系幹細胞;発生系譜

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H03028/
• 細胞系譜に着目したiPS細胞由来間葉系幹細胞の基盤的研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Kyoto University

  池谷 真

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  間葉系幹細胞;細胞系譜;発生系譜

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27719/
• Development of periodontal tissue regenerative allograft cell therapy by using clumps of MSCs and chondrogenic induction

  Grant-in-Aid for Scientific Research (B)

  Basic Section 57040:Regenerative dentistry and dental engineering-related

  Hiroshima University

  加治屋 幹人

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  間葉系幹細胞集塊;神経堤細胞由来間葉系幹細胞;顎骨オルガノイド;歯肉オルガノイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24533/
• iPS細胞由来中胚葉系細胞を用いて新たな靭帯再建法の確立を目指す研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Saga University

  村田 大紀

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  靭帯再建;iPS細胞由来中胚葉系細胞;スキャフォールドフリー;細胞構造体;靭帯組織体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24463/

External funds: others

• 機械刺激によるヒトiPS細胞からの中枢・末梢神経系への分化制御機構の解明と活用 （平成29年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2017, To 31 Mar. 2018

  池谷 真
• 機械刺激によるヒトiPS細胞からの中枢・末梢神経系への分化制御機構の解明と活用 （平成30年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2018, To 31 Mar. 2019

  池谷 真
• 再生医療用iPS 細胞ストック開発拠点

  再生医療実現拠点ネットワーク事業、再生医療実現拠点ネットワークプログラム

  From Apr. 2013, To Mar. 2023

  分担
• 疾患特異的iPS 細胞を活用した筋骨格系難病研究

  再生医療実現拠点ネットワーク事業、再生医療実現拠点ネットワークプログラム

  From Jan. 2013, To Mar. 2017

  分担
• ヒトiPS 細胞由来xeno-free 間葉系幹細胞作製技術の開発

  研究成果展開事業・研究成果最適展開支援プログラム（A-STEP）

  From Nov. 2012, To Oct. 2013

  代表

Education

Teaching subject(s)

• From 20 Jun. 2013, To 20 Jun. 2013

  医科学特論

  Spring, 医学研究科

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2026

  動物実験委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2024

  京都大学動物実験委員会 委員

Faculty management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2025

  発明委員会
• From 31 Mar. 2020, To 31 Mar. 2026

  CiRA研究インターンシップ委員会委員長、1号委員
• From 01 Apr. 2014, To 31 Mar. 2020

  組換えDNA実験安全委員会3号委員
• From 01 Apr. 2020, To 31 Mar. 2026

  共通機器管理運営委員会1号委員
• From 01 Apr. 2019, To 31 Mar. 2025

  動物実験委員会2号委員