Basic Information

Email Address

• Email Address

  okamoto.yusuke.7ckyoto-u.ac.jp

Professional Memberships

• From Jul. 2026, To Present

  日本補体学会
• From May 2026, To Present

  日本組織適合性学会
• From Oct. 2025, To Present

  日本エイズ学会
• From Aug. 2012, To Present

  日本造血・免疫細胞療法学会
• From Aug. 2025, To Present

  日本骨髄腫学会
• From Jun. 2025, To Present

  日本血栓止血学会
• From Nov. 2012, To Present

  日本臨床腫瘍学会
• From Jun. 2009, To Present

  日本内科学会
• From Apr. 2013, To Present

  日本輸血・細胞治療学会
• From May 2011, To Present

  日本血液学会

Academic Degree

• 25 Mar. 2019

  博士（医学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学大学院, 医学研究科, 医学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

Research History

• From Apr. 2025, To Present

  京都大学医学部附属病院, 血液内科, 特定病院助教
• From Oct. 2024, To Mar. 2025

  京都大学医学部附属病院 血液内科, 医員
• From Oct. 2019, To Sep. 2024

  Lunenfeld-Tanenbaum Research Institute, post-doctoral fellow
• From Apr. 2019, To Aug. 2019

  Kyoto University, 特定研究員

ID,URL

• ORCID ID

  0000-0002-9515-8139

• J-Global ID

  202501002224581837

researchmap URL

• https://researchmap.jp/yusuke.okamoto

Research

Research Interests

• 溶血性貧血
• 輸血免疫
• AA/PNH
• 先天性骨髄不全症候群
• MPN

Research Areas

• Life sciences, Hematology and oncology

Papers

• Pomalidomide successfully treated transfusion-dependent epistaxis in hereditary hemorrhagic telangiectasia: a case report

  Yusuke Okamoto; Takashi Sakamoto; Tomohiro Taya; Masaki Komiyama

  Annals of Hematology, 13 Oct. 2026

  
• Replication Stress Tolerance in Adult T-Cell Leukemia

  Yusuke Okamoto; Masayuki Kobayashi; Takashi Sakamoto; Kotaro Shirakawa; Akifumi Takaori-Kondo

  Biomolecules, 09 Sep. 2026

  
• T-cell large granular lymphocyte leukaemia with pure red cell aplasia harbouring a somatic STAT3 P715L mutation

  Yusuke Okamoto; Kenichi Ishiyama; Kazuhisa Chonabayashi; Junya Kanda; Munenori Kawai; Akihisa Fukuda; Yasuhito Nannya; Seishi Ogawa; Kouhei Yamashita; Akifumi Takaori

  BMJ Case Reports, Jun. 2026

  
• A diagnostic pitfall in cold agglutinin disease: KMT2D-mutated CAD-associated lymphoproliferative disorder with a CLL-like immunophenotype

  Yusuke Okamoto; Hiroshi Arima; Kenichi Ishiyama; Kazuhisa Chonabayashi; Junya Kanda; Kouhei Yamashita; Masakazu Fujimoto; Hironori Haga; Yasuhito Nannya; Seishi Ogawa; Akifumi Takaori-Kondo

  Oxford Medical Case Reports, 09 May 2026

  
• Acute diplopia caused by extramedullary multiple myeloma

  Yusuke Okamoto; Sho Koyasu; Akifumi Takaori-Kondo

  International Journal of Hematology, Apr. 2026

  
• Hemostatic rescue with rFVIIa in Bernard–Soulier syndrome refractory to HLA-matched platelet transfusion

  Yusuke Okamoto; Chisaki Mizumoto; Kouhei Yamashita; Seita Inoue; Susumu Saito; Naoki Morimoto; Akifumi Takaori-Kondo

  Annals of Hematology, 26 Feb. 2026

  
• Parvovirus B19 infection induces pure red cell aplasia after lung transplantation

  Yusuke Okamoto; Kenichi Ishiyama; Akira Matsumoto; Yusuke Tsuda; Miki Nagao; Masahiro Hirata; Masakazu Fujimoto; Hironori Haga; Yojiro Yutaka; Akifumi Takaori-Kondo

  Journal of Infection and Chemotherapy, Jan. 2026

  
• The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway

  Anfeng Mu; Yusuke Okamoto; Yoko Katsuki; Minoru Takata

  DNA Repair, Sep. 2024, Peer-reviewed

  
• [SLFN11 inhibition rescues the Fanconi anemia phenotype by stabilizing stalled replication forks].

  Okamoto Y; Mu A; Takata M

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 01 Jan. 2024, Peer-reviewed, Lead author

  
• Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response

  Erin Alvi; Ayako L. Mochizuki; Yoko Katsuki; Minori Ogawa; Fei Qi; Yusuke Okamoto; Minoru Takata; Anfeng Mu

  Communications Biology, 13 Oct. 2023, Peer-reviewed

  Access this paper :

  
• Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage

  Anfeng Mu; Asuka Hira; Minako Mori; Yusuke Okamoto; Minoru Takata

  DNA Repair, Oct. 2023, Peer-reviewed

  Access this paper :

  
• Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers

  Tomoharu Mori; Yusuke Okamoto; Anfeng Mu; Yoshimi Ide; Akiyo Yoshimura; Noriko Senda; Yukiko Inagaki‐Kawata; Masahiro Kawashima; Hiroyuki Kitao; Eriko Tokunaga; Yasuo Miyoshi; Shozo Ohsumi; Koichiro Tsugawa; Tomohiko Ohta; Toyomasa Katagiri; Shigeru Ohtsuru; Kaoru Koike; Seishi Ogawa; Masakazu Toi; Hiroji Iwata; Seigo Nakamura; Keitaro Matsuo; Minoru Takata

  Cancer Medicine, 07 Nov. 2022, Peer-reviewed

  
• Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia–like IBMFS ADH5/ALDH2 deficiency

  Anfeng Mu; Asuka Hira; Akira Niwa; Mitsujiro Osawa; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Kazuko Inoue; Keita Kondo; Masato T. Kanemaki; Tomonari Matsuda; Etsuro Ito; Seiji Kojima; Tatsutoshi Nakahata; Seishi Ogawa; Keigo Tanaka; Keitaro Matsuo; Megumu K. Saito; Minoru Takata

  Blood, 15 Apr. 2021, Peer-reviewed

  
• SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells

  Yusuke Okamoto; Masako Abe; Anfeng Mu; Yasuko Tempaku; Colette B. Rogers; Ayako L. Mochizuki; Yoko Katsuki; Masato T. Kanemaki; Akifumi Takaori-Kondo; Alexandra Sobeck; Anja-Katrin Bielinsky; Minoru Takata

  Blood, 21 Jan. 2021, Peer-reviewed, Lead author

  
• Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

  Felix A. Dingler; Meng Wang; Anfeng Mu; Christopher L. Millington; Nina Oberbeck; Sam Watcham; Lucas B. Pontel; Ashley N. Kamimae-Lanning; Frederic Langevin; Camille Nadler; Rebecca L. Cordell; Paul S. Monks; Rui Yu; Nicola K. Wilson; Asuka Hira; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Yusuke Okuno; Hideki Muramatsu; Yuichi Shiraishi; Masayuki Kobayashi; Toshinori Moriguchi; Tomoo Osumi; Motohiro Kato; Satoru Miyano; Etsuro Ito; Seiji Kojima; Hiromasa Yabe; Miharu Yabe; Keitaro Matsuo; Seishi Ogawa; Berthold Göttgens; Michael R.G. Hodskinson; Minoru Takata; Ketan J. Patel

  Molecular Cell, Dec. 2020, Peer-reviewed

  Access this paper :

  
• Regulation of R-loops and genome instability in Fanconi anemia

  Yusuke Okamoto; James Hejna; Minoru Takata

  The Journal of Biochemistry, 01 Mar. 2019, Peer-reviewed, Invited, Lead author

  
• FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R‐loops during mild replication stress

  Yusuke Okamoto; Masako Abe; Akiko Itaya; Junya Tomida; Masamichi Ishiai; Akifumi Takaori‐Kondo; Masato Taoka; Toshiaki Isobe; Minoru Takata

  The FEBS Journal, 27 Nov. 2018, Peer-reviewed, Lead author

  
• Replication stress induces accumulation of FANCD2 at central region of large fragile genes

  Yusuke Okamoto; Watal M Iwasaki; Kazuto Kugou; Kazuki K Takahashi; Arisa Oda; Koichi Sato; Wataru Kobayashi; Hidehiko Kawai; Ryo Sakasai; Akifumi Takaori-Kondo; Takashi Yamamoto; Masato T Kanemaki; Masato Taoka; Toshiaki Isobe; Hitoshi Kurumizaka; Hideki Innan; Kunihiro Ohta; Masamichi Ishiai; Minoru Takata

  Nucleic Acids Research, 31 Jan. 2018, Peer-reviewed, Lead author

  Access this paper :

  
• Successful Treatment of Cardiac Lymphoma

  Yusuke Okamoto; Yasunori Ueda

  Internal Medicine, 2015, Lead author

  
• Multiple Myeloma Mimicking Liver Metastases

  Yusuke Okamoto; Yasunori Ueda

  Internal Medicine, 2015, Lead author

  
• Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens

  Kazuya Okada; Akane Kunitomi; Kazuya Sakai; Hiroyuki Muranushi; Yusuke Okamoto; Taku Tsukamoto; Hiroyuki Sugiura; Hiroyuki Matsui; Tomoyasu Jo; Tomoaki Ueda; Tatsuhito Onishi; Masaru Ide; Shinya Kimura; Kenji Notohara; Yasunori Ueda

  Internal Medicine, 2015

  
• Myeloid blast crisis in chronic myeloid leukemia with a unique deletion near the BCR/ABL breakpoint

  Akane Kunitomi; Shinya Kimura; Yusuke Okamoto; Kazuya Sakai; Hiroyuki Muranushi; Taku Tsukamoto; Hiroyuki Sugiura; Hiroyuki Matsui; Tomoyasu Jo; Tomoaki Ueda; Kazuya Okada; Tatsuhito Onishi; Yasunori Ueda

  International Cancer Conference Journal, 16 May 2014

  

Misc.

• ロミプロスチム導入により在宅輸血依存から離脱し得た高齢重症再生不良性貧血の1例

  岡本裕介; 小西義延; 池田正俊; 武田孝平; 島津裕; 赤坂浩司

  日本輸血細胞治療学会誌, Oct. 2026, Peer-reviewed, Lead author

  
• Absolute Lymphocyte Count As an Independent Prognostic Factor of IPI and NCCN-IPI in DLBCL Patients

  Kazuya Okada; Shinichi Ochi; Takashi Nagayama; Shogo Nabe; Kazuya Sakai; Hiroyuki Muranushi; Yusuke Okamoto; Hiroyuki Sugiura; Aki Sato; Takayuki Sato; Takeshi Maeda; Tatsuhito Onishi; Yasunori Ueda

  BLOOD, Dec. 2014

  
• SUV Max Reduction Criteria of Interim Positron Emission Tomography Improves Prognostic Value in Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Review

  Yusuke Okamoto; Shinichi Ochi; Takashi Nagayama; Shogo Nabe; Kazuya Sakai; Hiroyuki Muranushi; Hiroyuki Sugiura; Kazuya Okada; Aki Sato; Takayuki Sato; Takeshi Maeda; Tatsuhito Onishi; Yasunori Ueda

  BLOOD, Dec. 2014

  
• 倉敷中央病院における後天性TTPの治療経験

  上田恭典; 上田恭典; 岡田和也; 岡田和也; 酒井和哉; 酒井和哉; 村主啓行; 村主啓行; 岡本裕介; 岡本裕介; 塚本拓; 塚本拓; 山崎尚也; 山崎尚也; 松井宏行; 松井宏行; 杉浦弘幸; 杉浦弘幸; 城友泰; 城友泰; 上田智朗; 上田智朗; 前田猛; 前田猛; 大西達人; 大西達人; 國富あかね; 國富あかね; 村田真由美; 薮田吉弘; 岩崎真子; 田坂文重

  日本血栓止血学会誌, 2014

  
• 当院における血栓性血小板減少性紫斑病の臨床的特徴と予後

  岡田 和也; 村主 啓行; 酒井 和哉; 岡本 裕介; 塚本 拓; 山崎 尚也; 杉浦 弘幸; 松井 宏行; 上田 智明; 城 友泰; 大西 達人; 國富 あかね; 薮田 吉弘; 村田 真由美; 田坂 文重; 上田 恭典

  日本アフェレシス学会雑誌, Nov. 2013

  
• Mogamulizumab治療後のCMV腸炎より致死的な経過をたどった成人T細胞性白血病リンパ腫の1例

  上田智朗; 武澤梨央; 武田千佳; 酒井和哉; 村主啓行; 岡本裕介; 塚本拓; 杉浦弘幸; 松井宏行; 城友泰; 岡田和也; 前田猛; 大西達人; 藤澤真義; 上田恭典

  臨床血液, 2014

  
• ANALYSIS OF TUMOR LYSIS SYNDROME TREATED IN OUR HOSPITAL

  Yusuke Okamoto; Taku Tsukamoto; Hiroyuki Sugiura; Hiroyuki Matsui; Tomoaki Ueda; Kazuya Okada; Tomoyasu Jo; Tatsuhito Onishi; Takeshi Maeda; Yasunori Ueda

  ANNALS OF ONCOLOGY, Oct. 2014

  
• SLFN11とファンコニ貧血

  岡本裕介; 牟安峰; 高田穣

  臨床血液, Nov. 2024, Peer-reviewed, Lead author

  

Presentations

• ファンコニ貧血iPS細胞におけるSLFN11の造血分化抑制機能

  岡本裕介; 髙田穣; 髙折晃史; 安原崇哲; 牟安峰

  第88回日本血液学会学術集会, 10 Oct. 2026

  
• SLFN11 depletion rescues the Fanconi anemia hematopoiesis in Fanconi iPS model

  Yusuke Okamoto; Minoru Takata; Akifumi Takaori-Kondo; Takaaki Yasuhara; Mu Anfeng

  The 87th Annual Meeting of the Japanese Society of Hematology, 12 Oct. 2025

  
• SLFN11欠損による複製フォークの安定化によってファンコニ貧血の表現型が改善する

  岡本裕介; Alvi Erin; Qi Fei; 勝木陽子; 高折(近藤)晃史; 安原崇哲; 牟安峰; 髙田穣

  第86回日本血液学会学術集会, 11 Oct. 2024

  
• SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.

  Yusuke Okamoto; Anfeng Mu; Ayako Mochizuki; Yoko Katsuki; Akifumi Takaori-Kondo; Minoru Takata

  第16回血液学若手研究者勉強会（麒麟塾）, 19 Jun. 2021, Invited

  
• Loss of SLFN11 gene expression rescues the Fanconi anemia phenotype by stabilizing stalled replication forks

  Yusuke Okamoto; Masako Abe; Mu Anfeng; Yasuko Tempaku; Colette B. Rogers; Ayako L. Mochizuki; Yoko Katsuki; Masato T. Kanemaki; Akifumi Takaori-Kondo; Alex Sobeck; Anja-Katrin Bielinsky; Minoru Takata

  32nd Fanconi Anemia Scientific Symposium, 17 Sep. 2020

  
• hnRNP U and DDX47 Are Novel FANCD2 Interactors That May Help to Resolve R-Loops during Mild Replication Stress

  Yusuke Okamoto; Masako Abe; Akiko Itaya; Junya Tomida; Akifumi Takaori-Kondo; Masato Taoka; Toshiaki Isobe; Minoru Takata

  60th Annual Meeting of American Society of Hematology, 29 Nov. 2018

  
• SUV Max Reduction Criteria of Interim Positron Emission Tomography Improves Prognostic Value in Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Review

  Yusuke Okamoto; Shinichi Ochi; Takashi Nagayama; Shogo Nabe; Kazuya Sakai; Hiroyuki Muranushi; Hiroyuki Sugiura; Kazuya Okada; Aki Sato; Takayuki Sato; Takeshi Maeda; Tatsuhito Onishi; Yasunori Ueda

  56th Annual Meeting of American Society of Hematology, 06 Dec. 2014

  

Books and Other Publications

• ファンコニ貧血の分子病態

  森美奈子岡本裕介高田穣, Joint work

  血液内科 科学評論社, Aug. 2019

  

Media Coverage

• T-cell large granular lymphocyte leukaemia with pure red cell aplasia harbouring a somatic STAT3 P715L mutation

  ユサコ株式会社(https://www.usaco.co.jp/article/index.html), 国内研究者論文紹介, Jun. 2026, Internet

  
• SLFN11遺伝子はゲノム分解を促進しゲノムを不安定化させることを解明 －抗がん剤の有効性と小児血液遺伝病の病態理解へ－

  京都大学, 最新の研究成果を知る, Aug. 2020, Pr

  

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  血液学Ⅱ

  8050, Fall, 医学部, 1

Academic, Social Contribution

Committee Memberships

• From Sep. 2025

  評議員, 日本血液学会