Basic Information

Email Address

• Email Address

  okamoto.yusuke.7ckyoto-u.ac.jp

Professional Memberships

• From Jun. 2025, To Present

  血栓止血学会
• From Nov. 2012, To Present

  日本臨床腫瘍学会
• From Jun. 2009, To Present

  日本内科学会
• From Apr. 2013, To Present

  日本輸血・細胞治療学会
• From May 2011, To Present

  日本血液学会

Academic Degree

• 25 Mar. 2019

  博士（医学）(京都大学)

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

Research History

• From Apr. 2025, To Present

  京都大学医学部附属病院, 血液内科, 特定病院助教
• From Oct. 2024, To Mar. 2025

  京都大学医学部附属病院 血液内科, 医員
• From Oct. 2019, To Sep. 2024

  Lunenfeld-Tanenbaum Research Institute, post-doctral fellow
• From Apr. 2019, To Aug. 2019

  Kyoto University, 特定研究員

ID,URL

• ORCID ID

  0000-0002-9515-8139

• J-Global ID

  202501002224581837

researchmap URL

• https://researchmap.jp/yusuke.okamoto

Research

Research Interests

• 先天性骨髄不全症候群
• DNA修復
• 特発性造血障害

Research Areas

• Life sciences, Hematology and oncology

Papers

• The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway

  Anfeng Mu; Yusuke Okamoto; Yoko Katsuki; Minoru Takata

  DNA Repair, Sep. 2024, Peer-reviewed

  
• [SLFN11 inhibition rescues the Fanconi anemia phenotype by stabilizing stalled replication forks].

  Okamoto Y; Mu A; Takata M

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 01 Jan. 2024, Peer-reviewed, Lead author

  
• Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response

  Erin Alvi; Ayako L. Mochizuki; Yoko Katsuki; Minori Ogawa; Fei Qi; Yusuke Okamoto; Minoru Takata; Anfeng Mu

  Communications Biology, 13 Oct. 2023, Peer-reviewed

  
• Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage

  Anfeng Mu; Asuka Hira; Minako Mori; Yusuke Okamoto; Minoru Takata

  DNA Repair, Oct. 2023, Peer-reviewed

  
• Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers

  Tomoharu Mori; Yusuke Okamoto; Anfeng Mu; Yoshimi Ide; Akiyo Yoshimura; Noriko Senda; Yukiko Inagaki‐Kawata; Masahiro Kawashima; Hiroyuki Kitao; Eriko Tokunaga; Yasuo Miyoshi; Shozo Ohsumi; Koichiro Tsugawa; Tomohiko Ohta; Toyomasa Katagiri; Shigeru Ohtsuru; Kaoru Koike; Seishi Ogawa; Masakazu Toi; Hiroji Iwata; Seigo Nakamura; Keitaro Matsuo; Minoru Takata

  Cancer Medicine, 07 Nov. 2022, Peer-reviewed

  
• Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia–like IBMFS ADH5/ALDH2 deficiency

  Anfeng Mu; Asuka Hira; Akira Niwa; Mitsujiro Osawa; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Kazuko Inoue; Keita Kondo; Masato T. Kanemaki; Tomonari Matsuda; Etsuro Ito; Seiji Kojima; Tatsutoshi Nakahata; Seishi Ogawa; Keigo Tanaka; Keitaro Matsuo; Megumu K. Saito; Minoru Takata

  Blood, 15 Apr. 2021, Peer-reviewed

  
• SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells

  Yusuke Okamoto; Masako Abe; Anfeng Mu; Yasuko Tempaku; Colette B. Rogers; Ayako L. Mochizuki; Yoko Katsuki; Masato T. Kanemaki; Akifumi Takaori-Kondo; Alexandra Sobeck; Anja-Katrin Bielinsky; Minoru Takata

  Blood, 21 Jan. 2021, Peer-reviewed, Lead author

  
• Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

  Felix A. Dingler; Meng Wang; Anfeng Mu; Christopher L. Millington; Nina Oberbeck; Sam Watcham; Lucas B. Pontel; Ashley N. Kamimae-Lanning; Frederic Langevin; Camille Nadler; Rebecca L. Cordell; Paul S. Monks; Rui Yu; Nicola K. Wilson; Asuka Hira; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Yusuke Okuno; Hideki Muramatsu; Yuichi Shiraishi; Masayuki Kobayashi; Toshinori Moriguchi; Tomoo Osumi; Motohiro Kato; Satoru Miyano; Etsuro Ito; Seiji Kojima; Hiromasa Yabe; Miharu Yabe; Keitaro Matsuo; Seishi Ogawa; Berthold Göttgens; Michael R.G. Hodskinson; Minoru Takata; Ketan J. Patel

  Molecular Cell, Dec. 2020, Peer-reviewed

  
• Regulation of R-loops and genome instability in Fanconi anemia

  Yusuke Okamoto; James Hejna; Minoru Takata

  The Journal of Biochemistry, 01 Mar. 2019, Peer-reviewed, Invited, Lead author

  
• FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R‐loops during mild replication stress

  Yusuke Okamoto; Masako Abe; Akiko Itaya; Junya Tomida; Masamichi Ishiai; Akifumi Takaori‐Kondo; Masato Taoka; Toshiaki Isobe; Minoru Takata

  The FEBS Journal, 27 Nov. 2018, Peer-reviewed, Lead author

  
• Replication stress induces accumulation of FANCD2 at central region of large fragile genes

  Yusuke Okamoto; Watal M Iwasaki; Kazuto Kugou; Kazuki K Takahashi; Arisa Oda; Koichi Sato; Wataru Kobayashi; Hidehiko Kawai; Ryo Sakasai; Akifumi Takaori-Kondo; Takashi Yamamoto; Masato T Kanemaki; Masato Taoka; Toshiaki Isobe; Hitoshi Kurumizaka; Hideki Innan; Kunihiro Ohta; Masamichi Ishiai; Minoru Takata

  Nucleic Acids Research, 31 Jan. 2018, Peer-reviewed, Lead author

  
• Successful Treatment of Cardiac Lymphoma

  Yusuke Okamoto; Yasunori Ueda

  Internal Medicine, 2015, Lead author

  
• Multiple Myeloma Mimicking Liver Metastases

  Yusuke Okamoto; Yasunori Ueda

  Internal Medicine, 2015, Lead author

  
• Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens

  Kazuya Okada; Akane Kunitomi; Kazuya Sakai; Hiroyuki Muranushi; Yusuke Okamoto; Taku Tsukamoto; Hiroyuki Sugiura; Hiroyuki Matsui; Tomoyasu Jo; Tomoaki Ueda; Tatsuhito Onishi; Masaru Ide; Shinya Kimura; Kenji Notohara; Yasunori Ueda

  Internal Medicine, 2015

  
• Myeloid blast crisis in chronic myeloid leukemia with a unique deletion near the BCR/ABL breakpoint

  Akane Kunitomi; Shinya Kimura; Yusuke Okamoto; Kazuya Sakai; Hiroyuki Muranushi; Taku Tsukamoto; Hiroyuki Sugiura; Hiroyuki Matsui; Tomoyasu Jo; Tomoaki Ueda; Kazuya Okada; Tatsuhito Onishi; Yasunori Ueda

  International Cancer Conference Journal, 16 May 2014

  

Misc.

• SLFN11とファンコニ貧血

  岡本裕介; 牟安峰; 高田穣

  臨床血液, Nov. 2024, Peer-reviewed, Lead author

  

Presentations

• SLFN11欠損による複製フォークの安定化によってファンコニ貧血の表現型が改善する

  岡本裕介; Alvi Erin; Qi Fei; 勝木陽子; 高折(近藤)晃史; 安原崇哲; 牟安峰; 髙田穣

  第86回日本血液学会学術集会, 11 Oct. 2024

  
• SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.

  Yusuke Okamoto; Anfeng Mu; Ayako Mochizuki; Yoko Katsuki; Akifumi Takaori-Kondo; Minoru Takata

  第16回血液学若手研究者勉強会（麒麟塾）, 19 Jun. 2021, Invited

  
• Loss of SLFN11 gene expression rescues the Fanconi anemia phenotype by stabilizing stalled replication forks

  Yusuke Okamoto; Masako Abe; Mu Anfeng; Yasuko Tempaku; Colette B. Rogers; Ayako L. Mochizuki; Yoko Katsuki; Masato T. Kanemaki; Akifumi Takaori-Kondo; Alex Sobeck; Anja-Katrin Bielinsky; Minoru Takata

  32nd Fanconi Anemia Scientific Symposium, 17 Sep. 2020

  
• hnRNP U and DDX47 Are Novel FANCD2 Interactors That May Help to Resolve R-Loops during Mild Replication Stress

  Yusuke Okamoto; Masako Abe; Akiko Itaya; Junya Tomida; Akifumi Takaori-Kondo; Masato Taoka; Toshiaki Isobe; Minoru Takata

  60th Annual Meeting of American Society of Hematology, 29 Nov. 2018

  
• SUV Max Reduction Criteria of Interim Positron Emission Tomography Improves Prognostic Value in Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Review

  Yusuke Okamoto; Shinichi Ochi; Takashi Nagayama; Shogo Nabe; Kazuya Sakai; Hiroyuki Muranushi; Hiroyuki Sugiura; Kazuya Okada; Aki Sato; Takayuki Sato; Takeshi Maeda; Tatsuhito Onishi; Yasunori Ueda

  56th Annual Meeting of American Society of Hematology, 06 Dec. 2014

  

Books and Other Publications

• ファンコニ貧血の分子病態

  森美奈子岡本裕介高田穣, Joint work

  血液内科 科学評論社, Aug. 2019