Taruno, Akiyuki(Graduate School of Medicine, Medicine) | Activity Database on Education and Research, Kyoto University

Taruno, Akiyuki

Graduate School of Medicine, Medicine Professor

Last Updated :2026/03/18

Basic Information

Faculty

Faculty of Medicine

Email Address

Email Address
taruno.akiyuki.7akyoto-u.ac.jp

Professional Memberships

From 2020, To Present
Association for Chemoreception Sciences (USA)

From 2013, To Present
THE JAPANESE ASSOCIATION FOR THE STUDY OF TASTE AND SMELL

From 2008, To Present
THE JAPAN NEUROSCIENCE SOCIETY

From 2005, To Present
THE PHYSIOLOGICAL SOCIETY OF JAPAN

From 2013, To 2021
The Biophysical Society

From 2013, To 2019
日本膜学会

Academic Degree

31 Mar. 2010
京都府立医科大学博士（医学）

Academic Resume (Undergraduate School/Majors)

京都府立医科大学, 医学部医学科, 卒業

Research History

From Jan. 2026, To Present
Graduate School of Medicine, Kyoto University, Department of Cellular and Molecular Physiology, Professor

From Sep. 2018, To Present
Graduate School of Medicine, Kyoto Prefectural University of Medicine, Department of Molecular Cell Physiology, Professor

From Oct. 2018, To Mar. 2022
JST PRESTO Researcher

From Apr. 2014, To Aug. 2018
Graduate School of Medicine, Kyoto Prefectural University of Medicine, Department of Molecular Cell Physiology, Senior Assistant Professor

From Apr. 2013, To Mar. 2014
Graduate School of Medicine, Kyoto Prefectural University of Medicine, Department of Molecular Cell Physiology, Assistant Professor

From Apr. 2011, To Mar. 2013
School of Medicine, University of Pennsylvania, Department of Physiology, Postdoctoral Fellow

From Apr. 2010, To Mar. 2011
Japan Society for the Promotion of Scienceapan, Excellent Young Researcher Overseas Visit Program, Researcher

From Apr. 2010, To Mar. 2011
School of Medicine, University of Pennsylvania, Department of Physiology, Visiting researcher

From Apr. 2008, To Mar. 2011
Japan Society for the Promotion of Science, Research Fellow

ID,URL

J-Global ID
201401060551618596
External link
https://www.cmp.med.kyoto-u.ac.jp

researchmap URL

https://researchmap.jp/akitaruno

Last Updated :2026/03/18

Research

Research Interests

Physiology

chemosensory system

身体－脳相関

チャネルシナプス

taste

気道防御反射

Research Areas

Life sciences, Physiology

Life sciences, Neuroscience - general

Life sciences, Nutrition and health science

Papers

Channel synapse mediates neurotransmission of airway protective chemoreflexes.
Shogo Soma; Norihito Hayatsu; Kengo Nomura; Mark W Sherwood; Tatsuro Murakami; Yoichiro Sugiyama; Naofumi Suematsu; Takanori Aoki; Yu Yamada; Moe Asayama; Mami Kaneko; Kento Ohbayashi; Misa Arizono; Masato Ohtsuka; Shun Hamada; Ichiro Matsumoto; Yusaku Iwasaki; Nobuhiko Ohno; Yasushi Okazaki; Akiyuki Taruno
Cell, 04 Apr. 2025, Peer-reviewed, Last author, Corresponding author

Shared gustatory sensor for acids and ammonium.
Akiyuki Taruno
Trends in neurosciences, Mar. 2024, Invited, Lead author, Last author, Corresponding author

Physiological Reports celebrates its first 10 years.
Josephine C Adams; Oliver J Price; Natasha Rogers; Sharon Rounds; Akiyuki Taruno; Arianne L Theiss; Shizuka Uchida; David C Wright
Physiological reports, Dec. 2023

Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion.
Yoshito Minami; Atsushi Hoshino; Yusuke Higuchi; Masahide Hamaguchi; Yusaku Kaneko; Yuhei Kirita; Shunta Taminishi; Toshiyuki Nishiji; Akiyuki Taruno; Michiaki Fukui; Zoltan Arany; Satoaki Matoba
Nature communications, 13 Jul. 2023

Molecular and Cellular Mechanisms of Salt Taste.
Akiyuki Taruno; Michael D Gordon
Annual review of physiology, 10 Feb. 2023, Peer-reviewed, Invited, Lead author, Corresponding author

A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels.
Masahiro Matsuo; Kazuyuki Seo; Akiyuki Taruno; Yasutaka Mizoro; Yoshiaki Yamaguchi; Masao Doi; Rhyuta Nakao; Hiroshi Kori; Takaya Abe; Harunori Ohmori; Keiko Tominaga; Hitoshi Okamura
Cell reports, 24 May 2022
Access this paper :

Posttranslational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation.
Motoki Okui; Tatsuro Murakami; Hongxin Sun; Chiaki Ikeshita; Narisato Kanamura; Akiyuki Taruno
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, May 2021, Peer-reviewed, Last author, Corresponding author

Taste transduction and channel synapses in taste buds.
Akiyuki Taruno; Kengo Nomura; Tsukasa Kusakizako; Zhongming Ma; Osamu Nureki; J Kevin Foskett
Pflugers Archiv : European journal of physiology, Jan. 2021, Peer-reviewed, Invited, Lead author, Corresponding author

Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.
Kanae Demura; Tsukasa Kusakizako; Wataru Shihoya; Masahiro Hiraizumi; Kengo Nomura; Hiroto Shimada; Keitaro Yamashita; Tomohiro Nishizawa; Akiyuki Taruno; Osamu Nureki
Science advances, Jul. 2020, Peer-reviewed, Corresponding author

All-Electrical Ca2+-Independent Signal Transduction Mediates Attractive Sodium Taste in Taste Buds.
Kengo Nomura; Miho Nakanishi; Fumiyoshi Ishidate; Kazumi Iwata; Akiyuki Taruno
Neuron, 25 Mar. 2020, Peer-reviewed, Lead author, Last author, Corresponding author

CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.
Makiko Kashio; Gao Wei-Qi; Yasuyoshi Ohsaki; Mizuho A Kido; Akiyuki Taruno
Scientific reports, 25 Feb. 2019, Peer-reviewed, Last author, Corresponding author

AAV-Mediated Gene Delivery to Taste Cells of the Tongue.
Akiyuki Taruno; Makiko Kashio
Methods in molecular biology (Clifton, N.J.), 2019, Peer-reviewed, Lead author, Corresponding author

CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes.
Zhongming Ma; Akiyuki Taruno; Makoto Ohmoto; Masafumi Jyotaki; Jason C Lim; Hiroaki Miyazaki; Naomi Niisato; Yoshinori Marunaka; Robert J Lee; Henry Hoff; Riley Payne; Angelo Demuro; Ian Parker; Claire H Mitchell; Jorge Henao-Mejia; Jessica E Tanis; Ichiro Matsumoto; Michael G Tordoff; J Kevin Foskett
Neuron, 02 May 2018, Peer-reviewed, Lead author

ATP Release Channels.
Akiyuki Taruno
International journal of molecular sciences, 11 Mar. 2018, Peer-reviewed, Lead author, Last author, Corresponding author

The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.
Misaki Matsumoto; Jia Zhang; Xueqing Zhang; Junjie Liu; Joy X Jiang; Kanji Yamaguchi; Akiyuki Taruno; Masato Katsuyama; Kazumi Iwata; Masakazu Ibi; Wenhao Cui; Kuniharu Matsuno; Yoshinori Marunaka; Yoshito Itoh; Natalie J Torok; Chihiro Yabe-Nishimura
Free radical biology & medicine, 01 Feb. 2018, Peer-reviewed

Quercetin is a Useful Medicinal Compound Showing Various Actions Including Control of Blood Pressure, Neurite Elongation and Epithelial Ion Transport.
Yoshinori Marunaka; Naomi Niisato; Hiroaki Miyazaki; Ken-Ichi Nakajima; Akiyuki Taruno; Hongxin Sun; Rie Marunaka; Motoki Okui; Toshiro Yamamoto; Narisato Kanamura; Haruka Kogiso; Yukiko Ikeuchi; Makiko Kashio; Shigekuni Hosogi; Takashi Nakahari
Current medicinal chemistry, 2018, Peer-reviewed

Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model.
Rie Marunaka; Akiyuki Taruno; Toshiro Yamamoto; Narisato Kanamura; Yoshinori Marunaka
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Peer-reviewed, Lead author

Innate and acquired tolerance to bitter stimuli in mice.
Emi Mura; Akiyuki Taruno; Minako Yagi; Kohei Yokota; Yukako Hayashi
PloS one, 2018, Peer-reviewed, Lead author

Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel.
Akiyuki Taruno; Hongxin Sun; Koichi Nakajo; Tatsuro Murakami; Yasuyoshi Ohsaki; Mizuho A Kido; Fumihito Ono; Yoshinori Marunaka
The Journal of physiology, 15 Sep. 2017, Peer-reviewed, Lead author, Corresponding author

Current-direction/amplitude-dependent single channel gating kinetics of mouse pannexin 1 channel: a new concept for gating kinetics.
Takeshi Nomura; Akiyuki Taruno; Makoto Shiraishi; Takashi Nakahari; Toshio Inui; Masahiro Sokabe; Douglas C Eaton; Yoshinori Marunaka
Scientific reports, 05 Sep. 2017, Peer-reviewed, Lead author

Hypotonicity activates a voltage-dependent membrane conductance in N2a neuroblastoma cells.
Akiyuki Taruno; Yoshinori Marunaka
Biochemical and biophysical research communications, 04 Mar. 2017, Peer-reviewed, Lead author, Corresponding author

Actions of Quercetin, a Polyphenol, on Blood Pressure.
Yoshinori Marunaka; Rie Marunaka; Hongxin Sun; Toshiro Yamamoto; Narisato Kanamura; Toshio Inui; Akiyuki Taruno
Molecules (Basel, Switzerland), 29 Jan. 2017, Peer-reviewed, Last author

Adeno-Associated Virus-Mediated Gene Transfer into Taste Cells In Vivo.
Akiyuki Taruno; Makiko Kashio; Hongxin Sun; Kenta Kobayashi; Hiromi Sano; Atsushi Nambu; Yoshinori Marunaka
Chemical senses, Jan. 2017, Peer-reviewed, Lead author, Corresponding author

Analysis of Aprotinin, a Protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model.
Kouhei Sasamoto; Rie Marunaka; Naomi Niisato; Hongxin Sun; Akiyuki Taruno; Giuseppe Pezzotti; Toshiro Yamamoto; Narisato Kanamura; Wenliang Zhu; Kyosuke Nishio; Toshio Inui; Douglas C Eaton; Yoshinori Marunaka
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Peer-reviewed, Lead author

Na+ homeostasis by epithelial Na+ channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax.
Yoshinori Marunaka; Rie Marunaka; Hongxin Sun; Toshiro Yamamoto; Narisato Kanamura; Akiyuki Taruno
Annals of translational medicine, Oct. 2016, Peer-reviewed

Calcium homeostasis modulator (CALHM) ion channels.
Zhongming Ma; Jessica E Tanis; Akiyuki Taruno; J Kevin Foskett
Pflugers Archiv : European journal of physiology, Mar. 2016, Peer-reviewed

Simulation of Cl(-) Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl(-) Transporter.
Kouhei Sasamoto; Naomi Niisato; Akiyuki Taruno; Yoshinori Marunaka
Frontiers in physiology, 2015, Peer-reviewed, Lead author

How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel.
Akiyuki Taruno; Ichiro Matsumoto; Zhongming Ma; Philippe Marambaud; J Kevin Foskett
BioEssays : news and reviews in molecular, cellular and developmental biology, Dec. 2013, Peer-reviewed, Lead author, Corresponding author

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes.
Akiyuki Taruno; Valérie Vingtdeux; Makoto Ohmoto; Zhongming Ma; Gennady Dvoryanchikov; Ang Li; Leslie Adrien; Haitian Zhao; Sze Leung; Maria Abernethy; Jeremy Koppel; Peter Davies; Mortimer M Civan; Nirupa Chaudhari; Ichiro Matsumoto; Göran Hellekant; Michael G Tordoff; Philippe Marambaud; J Kevin Foskett
Nature, 14 Mar. 2013, Peer-reviewed, Lead author

What is the role of interstitial pH in diabetes mellitus? Improving action of propolis on type II diabetes mellitus via pH regulation
Yoshinori Marunaka; Wataru Aoi; Shigekuni Hosogi; Naomi Niisato; Noriko Yokoyama; Hiroki Hayata; Hiroaki Miyazaki; Katsuyuki Kusuzaki; Akiyuki Taruno; Takeshi Nomura
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, Peer-reviewed

Inhibition of presynaptic Na(+)/K(+)-ATPase reduces readily releasable pool size at the avian end-bulb of Held synapse.
Akiyuki Taruno; Harunori Ohmori; Hiroshi Kuba
Neuroscience research, Feb. 2012, Peer-reviewed, Lead author

Regulation of epithelial sodium transport via epithelial Na+ channel.
Yoshinori Marunaka; Naomi Niisato; Akiyuki Taruno; Mariko Ohta; Hiroaki Miyazaki; Shigekuni Hosogi; Ken-Ichi Nakajima; Katsuyuki Kusuzaki; Eishi Ashihara; Kyosuke Nishio; Yoshinobu Iwasaki; Takashi Nakahari; Takahiro Kubota
Journal of biomedicine & biotechnology, 2011, Peer-reviewed

Analysis of blocker-labeled channels reveals the dependence of recycling rates of ENaC on the total amount of recycled channels.
Akiyuki Taruno; Yoshinori Marunaka
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Peer-reviewed, Lead author

Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure.
Shinsaku Tokuda; Naomi Niisato; Toshiki Nagai; Akiyuki Taruno; Ken-Ichi Nakajima; Hiroaki Miyazaki; Toshiki Yamada; Shigekuni Hosogi; Mariko Ohta; Kyosuke Nishio; Yoshinobu Iwasaki; Yoshinori Marunaka
Cell biology international, Sep. 2009, Peer-reviewed

Intracellular calcium plays a role as the second messenger of hypotonic stress in gene regulation of SGK1 and ENaC in renal epithelial A6 cells
Akiyuki Taruno; Naomi Niisato; Yoshinori Marunaka
American Journal of Physiology - Renal Physiology, Jan. 2008, Peer-reviewed

Aldosterone-induced modification of osmoregulated ENaC trafficking.
Naomi Niisato; Akiyuki Taruno; Yoshinori Marunaka
Biochemical and biophysical research communications, 14 Sep. 2007, Peer-reviewed, Lead author

Involvement of p38 MAPK in hypotonic stress-induced stimulation of beta- and gamma-ENaC expression in renal epithelium.
Naomi Niisato; Akiyuki Taruno; Yoshinori Marunaka
Biochemical and biophysical research communications, 06 Jul. 2007, Peer-reviewed

Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases
Akiyuki Taruno; Naomi Niisato; Yoshinori Marunaka
American Journal of Physiology - Renal Physiology, Jul. 2007, Peer-reviewed, Lead author

Action of neltenexine on anion secretion in human airway epithelia.
Naomi Niisato; Isao Hasegawa; Shinsaku Tokuda; Akiyuki Taruno; Ken-ichi Nakajima; Hiroaki Miyazaki; Yoshinobu Iwasaki; Yoshinori Marunaka
Biochemical and biophysical research communications, 18 May 2007, Peer-reviewed

Misc.

チャネルシナプスの発見とその生命機能
樽野陽幸
生体の科学, 2025, Invited, Lead author, Last author, Corresponding author

味覚の分子メカニズム
樽野陽幸
日本内科学雑誌, 2025, Invited, Lead author, Last author, Corresponding author

アンモニウムの味：酸味と共有するセンサー
樽野陽幸
実験医学, Jul. 2024, Invited, Lead author, Last author, Corresponding author

ENaCによるナトリウム味の分子細胞機構
樽野陽幸
腎と透析, Nov. 2023, Invited, Lead author, Last author, Corresponding author

味覚受容をつかさどる細胞分子機構
樽野陽幸
医学の歩み, 2022, Invited, Lead author, Last author, Corresponding author

味覚のしくみと味を認知する脳のはたらき
樽野陽幸
Milsil, 2021, Invited, Lead author, Last author, Corresponding author

味覚を担う第２の化学シナプス「チャネルシナプス」
樽野陽幸
Clinical Neuroscience, 2021, Invited, Lead author, Last author, Corresponding author

味覚受容の分子メカニズム
樽野陽幸
Clinical Neuroscience, 2021, Invited, Lead author, Last author, Corresponding author

味覚系特殊イオンチャネルシナプス
樽野陽幸
京都府立医科大学雑誌, 2019, Invited, Lead author, Last author, Corresponding author

味蕾における味覚受容メカニズム
樽野陽幸
嚥下医学, 2019, Invited, Lead author, Last author, Corresponding author

塩味の受容とそのメカニズムについて
樽野陽幸
日本味と匂学会誌, 2018, Invited, Lead author, Last author, Corresponding author

電位依存性のATPチャネルCALHM1-CALHM3複合体によるGタンパク質共役受容体に依存性の味覚の神経伝達
樽野陽幸; Zhongming Ma; Foskett JK
ライフサイエンス新着論文レビュー, 2018, Invited, Lead author, Corresponding author

甘味受容の仕組みと人工甘味料
樽野陽幸
食と医療, 2017, Invited, Lead author, Last author, Corresponding author

Adeno-Associated Virus-Mediated Gene Transfer into Taste Cells In Vivo (vol 42, pg 69, 2017)
Akiyuki Taruno; Yoshinori Marunaka
CHEMICAL SENSES, Jan. 2017, Peer-reviewed

Regulation of CALHM1 channel by protein S-palmitoylation
Akiyuki Taruno; Hongxin Sun; Makiko Kashio; Yoshinori Marunaka
CHEMICAL SENSES, Nov. 2016, Peer-reviewed

Adeno-associated virus-mediated gene transduction of taste cells in vivo
Makiko Kashio; Akiyuki Taruno; Hongxin Sun; Kenta Kobayashi; Hiromi Sano; Atsushi Nambu; Yoshinori Marunaka
CHEMICAL SENSES, Nov. 2016, Peer-reviewed

Simulation of Cl- secretion in epithelial tissues
Yoshinori Marunaka; Kouhei Sasamoto; Naomi Niisato; Akiyuki Taruno
FASEB JOURNAL, Apr. 2016, Peer-reviewed

N-Linked Glycosylation Regulates CALHM1 Channel Function and Subcellular Localization
Akiyuki Taruno; Hongxin Sun; Makiko Kashio; Yoshinori Marunaka
BIOPHYSICAL JOURNAL, Feb. 2016, Peer-reviewed

分子レベルで明らかになってきた舌で甘さを感じるしくみ
樽野陽幸, 丸中良典
砂糖類・でん粉情報（農畜産業振興機構）, 2015, Invited, Lead author, Corresponding author

味覚神経伝達を担う新規形質膜ATP放出イオンチャネルCALHM1の同定と上皮細胞イオンチャネルの膜局在の数理モデル解析
樽野陽幸
膜, 2015, Lead author, Last author, Corresponding author

明らかになってきたCALHMチャネルの構造と機能
樽野陽幸; Foskett JK; 丸中良典
実験医学, 2014, Invited, Lead author, Corresponding author

Calcium Homeostasis Modulator (CALHM) Ion Channels: Structure, Functions and Physiological Roles
FOSKETT J.KEVIN; MA ZHONGMING; SIEBERT ADAM P; LAMITINA TODD; MARAMBAUD PHILIPPE; TANIS JESSICA E; TARUNO AKIYUKI
膜, 01 Jan. 2014

Calcium homeostasis modulator (CALHM) ion channels: structure, function and physiological roles
FOSKETT J. KEVIN; MA ZHONGMING; SIEBERT ADAM; MARAMBAUD PHILIPPE; TANIS JESSICA; LAMITINA TODD; TARUNO AKIYUKI
膜シンポジウム, 25 Oct. 2013

CALHM1による味蕾における甘味・苦味・うま味のプリン作動性神経伝達
樽野陽幸; Ma Z; Foskett JK
細胞工学, 2013, Invited, Lead author, Corresponding author

ATP透過性イオンチャネルCALHM1は味蕾における甘味, 苦味, うま味の受容に必須である
樽野陽幸; Foskett JK
ライフサイエンス新着論文レビュー, 2013, Invited, Lead author, Corresponding author

CALHM1 ion channel mediates purinergic neurotransmission in the taste bud during sweet, bitter and umami perception
Akiyuki Taruno; Valerie Vingtdeux; Ang Li; Ma Zhongming; Makoto Ohmoto; Ichiro Matsumoto; Sze Leung; Maria Abernethy; Gennady Dvoryanchikov; Mortimer M. Civan; Nirupa Chaudhari; Goran Hellekant; Michael G. Tordoff; Philippe Marambaud; J. Kevin Foskett
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013

CALHM1 is an Extracellular Ca2+- and Voltage-Gated ATP Permeable Ion Channel
Zhongming Ma; Akiyuki Taruno; Adam P. Siebert; Ang Li; Mortimer M. Civan; J. Kevin Foskett
BIOPHYSICAL JOURNAL, Jan. 2013, Peer-reviewed

Membrane Trafficking of Epithelial Sodium Channel
TARUNO Akiyuki; NIISATO Naomi; MARUNAKA Yoshinori
MEMBRANE, 01 Nov. 2011

Presentations

Discovery of the channel synapse and its biological functions
Taruno A.
The 5th International Symposium on Frontiers in Molecular Science, KYOTO, JAPAN, 29 Aug. 2025, Invited

Channel synapse mediate upper airway protective chemoreflexes
Taruno A.
The 28th Annual Meeting of the Korean Society for Brain and Neural Sciences (in conjunction with the 3rd CJK Neuroscience Meeting), INCHEON, SOUTH KOREA, 25 Aug. 2025, Invited

Epithelial tuft cells initiate upper airway protective chemoreflexes
Taruno A.
第48回日本神経科学大会, 新潟, 26 Jul. 2025, Invited

チャネルシナプスの発見とその構造・機能に基づく生命機能の探求
Taruno A.
第77回日本細胞生物学会・第58回日本発声生物学会合同大会（EVIDENTランチョンセミナー）, 名古屋, 15 Jul. 2025, Invited

塩味の分子細胞メカニズム
Taruno A.
第70回日本透析医学会学術集会・総会, 大阪, 28 Jun. 2025, Invited

Epithelial tuft cells trigger upper airway protective chemoreflexes
Taruno A.
日本薬学会第145年会, 福岡, 27 Mar. 2025

Pou2f3+ chemosensory cells trigger upper airway protective chemoreflexes
Taruno A.
第130回日本解剖学会・第102回日本生理学会・第98回日本薬理学会合同大会, 千葉, 17 Mar. 2025

Channel synapse mediate protective upper airway chemoreflexes
Taruno A.
The 21st International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, OKAYAMA, JAPAN, 01 Mar. 2025, Invited

侵害刺激に対する気道防御反射を担う感覚細胞の同定
Taruno A.
第10回ケモビ研究会（Chemosensation and Behavior Workshop 2025）, 千葉, 15 Feb. 2025

塩味の分子細胞メカニズム
Taruno A.
第318回東京歯科大学学会シンポジウム, 東京, 19 Oct. 2024, Invited

味わいのサイエンスとその医学的展開
Taruno A.
世界脳週間2024, 京都（東山高等学校）, 20 Jul. 2024, Invited

Epithelial chemosensation of the larynx that triggers airway protective reflexes
Taruno A.
The 19th International Symposium on Olfaction and Taste, ICELAND, 24 Jun. 2024

味覚のサイエンスとその医学的展開
Taruno A.
日本内科学会生涯教育講演会, 大阪, 12 May 2024, Invited

A chemical synapse that lacks vesicles—channel synapse—
Taruno A.
University of British Columbia. Neuroscience Research Colloquium, VANCOUVER, CANADA, 19 Apr. 2024, Invited

味覚のサイエンス－研究の動向と最近の知見－
Taruno A.
京都口腔外科臨床研究会, 京都, 20 Jan. 2024, Invited

味覚を司る分子細胞メカニズム
Taruno A.
第14回岐阜薬科大学機能性健康食品研究講演会, 岐阜, 03 Dec. 2023, Invited

Molecular and cellular mechanisms of sodium taste
Taruno A.
The 10th Federation of the Asian and Oceanian Physiological Societies Congress, SOUTH KOREA, 01 Nov. 2023, Invited

The channel synapse mediates neurotransmission of taste and beyond
Taruno A.
Korean Society for Chemical Senses and Ingestive Behavior (KoSCI) Fall Annual Symposium, SOUTH KOREA, 31 Oct. 2023, Invited

The channel synapse mediates airway protective chemoreflexes
Taruno A.
生理学研究所シナプス研究会, 鹿児島, 20 Oct. 2023, Invited

チャネルシナプスシナプス小胞に依存しない化学神経伝達機構
Taruno A.
ソフィオンバイオサイエンス教育講演, 高崎, 19 Oct. 2023, Invited

味覚サイエンスの最新知見—減塩に向けて—
Taruno A.
第67回広島高血圧・生活習慣病研究会, 広島, 11 Oct. 2023, Invited

塩味の起源と分子細胞メカニズム
Taruno A.
第45回日本高血圧学会総会, 大阪, 16 Sep. 2023, Invited

Single-cell transcriptomics uncovers taste cells responsible for sodium taste
Taruno A.
日本味と匂学会第57回大会, 東京, 13 Sep. 2023

シナプス小胞に依存しない化学神経伝達—チャネルシナプス—
Taruno A.
第６回和光－精神神経懇話会, 東京, 26 Aug. 2023, Invited

構造と機能からみえてきた神経伝達の新様式—チャネルシナプス—
Taruno A.
第46回日本神経科学大会（Evidentランチョンセミナー）, 仙台, 03 Aug. 2023, Invited

味覚の科学 up-to-date—減塩に向けて—
Taruno A.
第23回日本抗加齢医学会総会, 東京, 11 Jun. 2023, Invited

Cellular and molecular mechanisms underlying airway protective reflexes
Taruno A
第100回日本生理学会大会, 京都, 14 Mar. 2023

塩のおいしさを生み出す味覚のしくみ
Taruno A.
北九州市保健福祉局健康推進課栄養改善事業研修, 北九州, 06 Mar. 2023, Invited

新たな神経伝達様式であるチャネルシナプスの構造と機能
Taruno A.
生理学研究所研究会細胞の局所コミュニティ研究会（生理学研究所研究会）, 岡崎, 19 Dec. 2022, Invited

塩のおいしさを司るナトリウム味受容の細胞分子機構
Taruno A
第43回日本臨床薬理学会学術総会, 横浜, 01 Dec. 2022

チャネルシナプス―生体内外の化学感覚を担う上皮性シナプス―
Taruno A.
第96回日本薬理学会年会, 横浜, 30 Nov. 2022

塩味におけるナトリウムの役割
Taruno A.
感覚研究コンソーシアム第２回味覚ワーキンググループ, オンライン, 12 Sep. 2022

チャネルシナプス― 味覚と化学嚥下反射を担う特殊化学シナプス―
Taruno A.
第 39 回耳鼻咽喉科ニューロサイエンス研究会, 京都, 20 Aug. 2022, Invited

チャネルシナプス:シナプス小胞に依存しない新たな化学神経伝達機構
Taruno A.
千里ライフサイエンスセミナーT2, 大阪, 28 Jul. 2022, Invited

Channel synapse: a chemical synapse where transmitter release is mediated by ion channel pores
Taruno A.
第45回日本神経科学大会, 沖縄, 30 Jun. 2022

Channel synapse: a chemical synapse where transmitter release is mediated by ion channel pores
Taruno A.
Ion Channel Modulation Symposium 2022, UK, 22 Jun. 2022, Invited

Gustatory neurotransmission mediated via the channel synapse
Taruno A.
the 44th Annual Meeting of Association for Chemoreception Sciences, USA, 22 Apr. 2022, Invited

The channel synapse mediates epithelial chemosensory neurotransmission
Taruno A.
第99回日本生理学会大会, 仙台, 18 Mar. 2022

The channel synapse mediates gustatory neurotransmission
Taruno A.
日本農芸化学会大会, 京都, 16 Mar. 2022

チャネルシナプス：シナプス小胞に依存しない化学神経伝達機構
Taruno A.
生理学研究所研究会シナプス研究会「シナプスの理解深化からの神経回路動態の再考」, 岡崎, 29 Nov. 2021, Invited

Physiological roles of CALHM1/3 channels ~ Channel Synapse ~
Taruno A
The 73rd Korean Physiological Society Annual Meeting, SOUTH KOREA, 27 Oct. 2021, Invited

塩味の細胞と分子のメカニズム
Taruno A.
生理学研究所研究会上皮膜研究会「上皮膜輸送の多様性・調和機構を基盤とする異分野融合研究の創出」, 岡崎, 09 Sep. 2021, Invited

光に照らし出された塩味受容の細胞分子メカニズム
Taruno A.
第92回日本動物学会大会, 米子, 04 Sep. 2021

Taste Coding and “Channel Synapse” in the Gustatory System
Taruno A.
The 35th Joint Annual Conference of Biomedical Science, TAIWAN, 27 Jun. 2021, Invited

Salt-responsive Cells – A Unique Cell Type?
Taruno A
The 42nd Annual Meeting of the Association for Chemoreception Sciences, Apr. 2021, Invited

味覚神経伝達を担う “チャネルシナプス”の構造と機能
Taruno A
自然科学研究機構ネットワーク型研究加速事業生理研プロジェクト「機能タンパク質の構造と機能のダイナミクスと、それに基づく細胞・生体システム作動機構の研究拠点の形成」シンポジウム, Mar. 2021, Invited

Cellular and molecular mechanisms underlying sodium taste in taste buds
Taruno A
第98回日本生理学会大会, Mar. 2021, Invited

Transduction and coding of sodium taste in taste buds
Taruno A
生理学研究所研究会「イオンチャネルと生体膜のダイナミズム：構造生物学の先にあるもの」, 06 Oct. 2020, Invited

塩味受容の細胞と分子のメカニズム −チャネルシナプスの構造と生理−
Taruno A
日本味と匂学会第54回大会, Oct. 2020, Invited

All-electrical signal transduction and “channel synapses” mediate sodium taste
Taruno A.
第5回食欲・食嗜好研究会, 岡崎, 05 Sep. 2020, Invited

All-electrical signal transduction and “channel synapses” mediate sodium taste
Taruno A
第43回日本神経科学大会, Jul. 2020

All-electrical signal transduction and “channel synapses” mediate sodium taste
Taruno A
The 18th International Symposium on Olfaction and Taste, USA, Jun. 2020, Invited

Cells and transduction of sodium taste at the periphery
Taruno A
The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, Nov. 2019, Invited

味覚系特殊イオンチャネルシナプスの構造と分子機構
Taruno A
第３回感覚器研究イニシアチブ・シンポジウム「感覚と脳−基礎から臨床へ−」, Apr. 2019, Invited

Ion channel synapses of the taste bud
Taruno A.; Ma Z.; Ohmoto M.; Matsumoto I.; Kido MA; Tordoff MG; Foskett JK
The 9th Federation of the Asian and Oceanian Physiological Societies (FAOPS) Congress, KOBE, JAPAN, 2019, Invited

CALHMs: Fast-activating voltage-gated ATP channels for rapid purinergic neurotransmission
Taruno A; Ma Z; Ohmoto M; Matsumoto I; Kido MA; Tordoff MG; Foskett JK
The 49th National Institute of Physiological Sciences International Symposium “Ion channels: looking back, seeing ahead”, Dec. 2018, Invited

Ion channel synapses of the taste bud
Taruno A; Ma Z; Ohmoto M; Matsumoto I; Kido MA; Tordoff MG; Foskett JK
The 17th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, Nov. 2018, Invited

イオンチャネルから味覚へ（研究奨励賞受賞講演）
Taruno A
第52回日本味と匂学会大会, Oct. 2018, Invited

Ion channel synapses in taste buds
Taruno A; Ma Z; Ohmoto M; Matsumoto I; Tordoff MG; Foskett JK
第52回日本味と匂学会大会, Oct. 2018, Invited

Taste cells lacking synapses open a wide pore channel for rapid neurotransmission of tastes
Taruno A
第56回日本生物物理学会年会, Sep. 2018, Invited

CALHM1/3, a novel voltage-gated ATP-permeable channel, mediates action potential dependent rapid purinergic neurotransmission of tastes
Taruno A.
第41回日本神経科学大会, Jul. 2018

塩味の受容とそのメカニズムについて
Taruno A
うま味研究会公開シンポジウム, Jun. 2018, Invited

A CALHM1/CALHM3 heteromeric channel mediates purinergic neurotransmission of sweet, bitter, and umami tastes
Taruno A
第95回日本生理学会大会, Mar. 2018, Invited

CALHM channel-mediated neurotransmission of tastes
Taruno A
The 19th Scientific Meeting of the Australasian Association for ChemoSensory Science, Dec. 2017

Neurotransmission of taste mediated by calcium homeostasis modulator ion channels
Taruno A
第94回日本生理学会大会, Mar. 2017, Invited

Induction of foreign genes in taste cells in vivo
Taruno A
The 15th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, Dec. 2016, Invited

Homologous CALHM subunits assemble to form a novel voltage-gated ATP channel
Taruno A
第39回日本神経科学大会, Jul. 2016, Invited

Purinergic neurotransmission of taste by CALHM channel
Taruno A.
The 17th International Symposium on Olfaction and Taste, Jun. 2016, Invited

S-パルミトイル化修飾によるCALHM1チャネル機能制御
Taruno A.
日本膜学会第38年会, 東京, May 2016

CALHM1 and CALHM3 are assembled to form a novel voltage-gated ATP channel
Taruno A.
第93回日本生理学会大会, Mar. 2016, Invited

CALHM・Connexin・Pannexin/Innexin ion channel superfamily
Taruno A
第38回日本分子生物学会・第88回日本生化学会合同大会, Dec. 2015, Invited

CAL1APの同定とCALHM1/CAL1APチャネルの機能解析
Taruno A.
第108回近畿生理学談話会, 大阪, 24 Oct. 2015

味覚神経伝達を担う新規形質膜ATP放出イオンチャネルCALHM1の同定と上皮細胞イオンチャネルの膜局在の数理モデル解析
Taruno A
日本膜学会第37年会膜学研究奨励賞受賞記念講演, 東京, 15 May 2015

Structure and Function of CALHM Ion Channels
Taruno A; Ma Z; Niisato N; Miyazaki H; Kashio M; Sun H; Marunaka Y; Foskett JK
膜シンポジウム2014, Nov. 2014

味覚神経伝達を担う新規ATP放出イオンチャネルCALHM1の同定
Taruno A.
生理学研究所研究会粘膜免疫学と膜輸送生理学の融合, 岡崎, Oct. 2014

Calcium Homeostasis Modulator (CALHM) ion channel family encoding voltage-gated ATP release ion channels involved in non-synaptic purinergic neurotransmission
Taruno A; Foskett JK; Marunaka Y
第37回日本神経科学大会, Sep. 2014, Invited

Calcium Homeostasis Modulator (CALHM): A novel ion channel family encoding voltage-gated ATP release ion channels involved in non-synaptic neurotransmission from taste cells
Taruno A; Marunaka Y; Foskett JK
第91回日本生理学会大会, Mar. 2014, Invited

CALHM1イオンチャネルを介した味蕾における甘味・苦味・旨味の神経伝達機構の解明
Taruno A.
生理学研究所研究会細胞センサーの分子機構・相互関連・ネットワーク研究会, 岡崎, Nov. 2013

CALHM1: identification of a bona fide ion channel mediator of purinergic neurotransmission of sweet, bitter and umami tastes
Taruno A
The 11th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception, Oct. 2013, Invited

CALHM1: an ion channel mediator of purinergic neurotransmission of sweet, bitter and umami tastes from taste cells
Taruno A; Foskett JK
第47回日本味と匂学会大会, Sep. 2013, Invited

CALHM1 ion channel mediates purinergic neurotransmission in the taste bud during sweet, bitter and umami perception
Taruno A; Vingtdeux V; Li A; Ma Z; Ohmoto M; Matsumoto I; Leung S; Abemethy M; Dvoryanchikov G; Civan MM; Chaudhari N; Hellekant G; Tordoff MG; Marambaud P; Foskett JK
第90回日本生理学会大会, Mar. 2013, Invited

低浸透圧刺激による上皮型Na+チャネル(ENaC)の機能制御
Taruno A.
生理学研究所研究会上皮膜機能活性化物質と上皮膜防御の最前線, 岡崎, Nov. 2007

Roles of receptor tyrosine kinases on the hyposmolality-induced Na+ reabsorption through PI3K-SGK1-independent pathway
Taruno A.
第98回近畿生理学談話会, 大津, Oct. 2005

Books and Other Publications

標準生理学第10版
Contributor, 味覚
Mar. 2025
Find Kyoto University's collection of books :

カラー図解人体の正常構造と機能 = Structure, function and materials of the human body
坂井, 建雄; 河原, 克雅, Contributor, 味覚
日本医事新報社, Jan. 2025
Find Kyoto University's collection of books :

生理学用語ハンドブック
日本生理学会用語委員会; 日本生理学会, Contributor, 味覚生理学用語
丸善出版, Mar. 2024
Find Kyoto University's collection of books :

耳鼻咽喉科頭頸部外科領域のリハビリテーション医学・医療テキスト
久保俊一; 村上信五; 日本リハビリテーション医学教育推進機構; 日本耳鼻咽喉科頭頸部外科学会; 日本言語聴覚士協会; 日本理学療法士協会; 日本リハビリテーション医学会; 土井, 勝美; 徳永, 大作, Contributor, 嗅覚・味覚の解剖と生理
日本リハビリテーション医学教育推進機構, Jun. 2022
Find Kyoto University's collection of books :

摂食と健康の科学
Contributor, 味覚の受容
朝倉書店, 2020

ガイトン生理学原著第13版
樽野陽幸, Joint translation, 第54章（味覚と嗅覚）
エルゼビア・ジャパン, Mar. 2018, Not refereed

Methods in Molecular Biology "Adeno-Associated Virus Vectors: Design and Delivery"
Taruno A; Kashio M, Joint work, AAV-Mediated Gene Deliery to Taste Cells of the Tongue.
Springer, Berlin, 2018, Not refereed

Industrial Property Rights

特願2024-86265, 単離された喉頭Pou2f3発現細胞、及びマウスにおける咳嗽反応のモニタリング方法
樽野陽幸; 岡崎康司; 早津徳人

Awards

30 Oct. 2018
研究奨励賞（日本味と匂学会）

12 Mar. 2018
安藤百福賞「発明発見奨励賞」（安藤スポーツ・食文化振興財団食創会）

13 Oct. 2021
バイオインダストリー奨励賞（バイオインダストリー協会）

05 Jul. 2019
三島海雲学術賞（公益財団法人三島海雲記念財団）

15 May 2015
膜学研究奨励賞（日本膜学会）

20 Apr. 2022
Ajinomoto Award (Mid-career Investigator Award)

17 Mar. 2014
入澤宏・彩記念若手研究奨励賞（日本生理学会）

14 Apr. 2021
科学技術分野の文部科学大臣表彰・若手科学者賞

07 Mar. 2008
青蓮賞（京都府立医科大学学友会）

29 Mar. 2018
奨励賞（日本生理学会）

Media Coverage

ビールの「のどごし」実は防御反応か異物として飲み下しているだけ？京都府立医科大研究チーム
京都新聞, 29 May 2025, Paper

ビールの喉ごし科学で解明？
TBS, THE TIME,, 29 May 2025, Media report

咳や嚥下を引き起こす新しい感覚器官を喉で発見ビールの「のどごし」に関係か、京都府立医大など
JSTサイエンスポータル, 26 May 2025, Internet

せき起こす細胞発見京都府立医大、マウスの喉に
日本経済新聞オンライン, 14 Apr. 2025, Internet

ビールの「のどごし」は、文字通り喉で味わっている？…京都府立医科大チームが苦味を感じる感覚細胞を発見
読売新聞, 14 Apr. 2025, Paper

せきなど引き起こす新たな感覚細胞マウスの「のど」で発見
NHK, ニュース, 12 Apr. 2025, Media report

塩味を感じる細胞の情報伝達を解明おいしい減塩で目指せ健康長寿
JST, JSTnews, 15 Jun. 2020, Internet

塩味感じる仕組み府立医大教授ら解明食品開発に応用も
読売新聞, 10 May 2020, Paper

「おいしい」塩味を感じる分子メカニズムを解明
MONOist, 16 Apr. 2020, Internet

塩味をおいしく感じる舌の細胞を特定情報伝達の仕組みも明らかに
JST, サイエンスポータル, 01 Apr. 2020, Internet

塩味を感じるメカニズムを解明美味しい減塩への応用京都府立医科大ら
財経新聞, 01 Apr. 2020, Internet

京都府立医大、“おいしい”塩味は味蕾の電気仕掛けシグナル伝達で感じる
日経バイオテク, 31 Mar. 2020, Internet

「塩味」感じる仕組み解明
日刊工業新聞, 31 Mar. 2020, Paper

External funds: Kakenhi

The raison d'etre of classical synapses in taste buds
Grant-in-Aid for Scientific Research (B)
Basic Section 57010:Oral biological science-related
Okayama University
Ryusuke Yoshida
From 01 Apr. 2024, To 31 Mar. 2025, Project Closed
味覚;シナプス;酸味;細胞死;情報伝達;味蕾;SNAP25;GAD;味細胞;味神経;塩化アンモニウム;遺伝子改変マウス;伝達物質
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21484/

Comprehensive study of channel synapses
Grant-in-Aid for Scientific Research (A)
Medium-sized Section 48:Biomedical structure and function and related fields
Kyoto Prefectural University of Medicine
樽野陽幸
From 01 Apr. 2023, To 31 Mar. 2028, Granted
シナプス;CALHM;味覚;上皮;イオンチャネル;迷走神経;神経伝達;ATP
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00400/

Whole-body search of the channel synapse in mice
Grant-in-Aid for Challenging Research (Exploratory)
Medium-sized Section 48:Biomedical structure and function and related fields
Kyoto Prefectural University of Medicine
Akiyuki Taruno
From 30 Jul. 2020, To 31 Mar. 2023, Project Closed
シナプス;ATP;イオンチャネル;CALHM;ミトコンドリア
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21505/

Molecular mechanisms underlying function and formation of the mitochondria-plasma membrane communication zone
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Biological Sciences
Kyoto Prefectural University of Medicine
樽野陽幸
From 01 Apr. 2020, To 31 Mar. 2022, Granted
ミトコンドリア;神経伝達;味覚;イオンチャネル;シナプス;細胞膜
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H04908/

Elucidation of channel synapse-mediated neurotransmission of tastes
Grant-in-Aid for Scientific Research (B)
Basic Section 57010:Oral biological science-related
Kyoto Prefectural University of Medicine
Akiyuki Taruno
From 01 Apr. 2019, To 31 Mar. 2023, Project Closed
味覚;シナプス;神経伝達;ATP;イオンチャネル;CALHM;ミトコンドリア;チャネルシナプス;塩味
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03819/

Neurotransmission of sensory information through CALHM ion channels
Grant-in-Aid for Challenging Exploratory Research
Kyoto Prefectural University of Medicine
Akiyuki Taruno
From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
シナプス;イオンチャネル;CALHM;味覚;神経伝達;翻訳後修飾;生理学;感覚系
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15181/

Heteromeric CALHM1/3 in neurotransmission of taste cells
Grant-in-Aid for Young Scientists (B)
Kyoto Prefectural University of Medicine
Makiko Kashio
From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
味覚;ATP;イオンチャネル
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18974/

Sensing, processing and neurotransmission of taste in the taste buds
Grant-in-Aid for Young Scientists (A)
Kyoto Prefectural University of Medicine
Akiyuki TARUNO
From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
味覚;イオンチャネル;神経伝達;ATP;CALHM;味蕾;カルシウムイメージング;生理学;感覚系;塩味;GCaMP
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26713008/

味蕾に発現する機能未知CALHM遺伝子の機能解析
Grant-in-Aid for Research Activity Start-up
Kyoto Prefectural University of Medicine
樽野陽幸
From 30 Aug. 2013, To 31 Mar. 2015, Declined
イオンチャネル;神経伝達;ATP;味覚
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25893201/

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Taruno, Akiyuki

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External funds: Kakenhi

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