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Chuma, Shinichiro

Institute for Life and Medical Sciences (LiMe) Associate Professor

Chuma, Shinichiro
list
    Last Updated :2025/05/27

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Medicine, 医学専攻 発生分化研究, 准教授
    • Graduate School of Medicine, 医科学専攻 発生分化研究, 准教授

    Academic Degree

    • 博士（理学）(総合研究大学院大学)

    Academic Resume (Graduate Schools)

    • 総合研究大学院大学, 生命科学研究科博士後期課程遺伝学専攻, 修了

    Language of Instruction

    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/27

      Research

      Research Topics, Overview of the research

      • Research Topics

        生殖系列サイクルの遺伝的安定性の発生制御メカニズム

      • Overview of the research

        生物の遺伝情報は常に損傷と修復を繰り返して変化する。多細胞生物では受精を起点に個々の細胞の遺伝情報は変異を蓄積して癌や老化等の原因になるものと考えられる。しかし各細胞系譜の遺伝的安定性は均一ではなく、幹細胞システムは分化細胞と比べて遺伝情報をより安定に維持する事で生体恒常性を保ち、また生殖系列サイクルは特に遺伝情報の安定性が高いものと考えられる。しかし、遺伝的安定性がどの様に発生プログラムと連携して機能調節を受けるのか、また何故生殖系列サイクルの遺伝的安定性は特に高いのか、その制御基盤の理解は殆ど進んでいない。我々は哺乳類の初期発生過程と生殖系列サイクルの遺伝的安定性の発生制御メカニズムの解明とその理解に基づいた再構成を目的として、マウス多能性幹細胞と生殖幹細胞の in vitro 増殖分化モデルおよび in vivo 初期胚や生殖細胞を用いた実証研究により、(1)初期発生と生殖系列サイクルの遺伝的安定性の発生制御の全体像、(2)遺伝的安定性の制御遺伝子群の発現調節機構、(3)遺伝的安定性の人為制御が細胞・個体に与える影響、の解明を目指している。遺伝的安定性の発生制御は生物学上の重要課題であると共にその操作技術は幹細胞リソースの応用等にも広く重要である。

      Research Interests

      • developmental biology
      • genetics
      • epigenome
      • germline
      • genome
      • stem cell

      Research Areas

      • Life sciences, Molecular biology
      • Life sciences, Genetics
      • Life sciences, Developmental biology

      Papers

      • Ca2+-evoked sperm cessation determines embryo number in mammals
        Hitomi Watanabe; Daiya Ohara; Shinichiro Chuma; Yusuke Takeuchi; Tomoatsu Takano; Ami Katanaya; Satohiro Nakao; Akihisa Kaneko; Takatoku Oida; Tatsuya Katsuno; Takuya Uehata; Toru Takeo; Munehiro Okamoto; Keiji Hirota; Gen Kondoh
        16 Sep. 2024, Lead author
      • Mitosis Detection from Partial Annotation by Dataset Generation via Frame-Order Flipping
        Kazuya Nishimura; Ami Katanaya; Shinichiro Chuma; Ryoma Bise
        Medical Image Computing and Computer Assisted Intervention MICCAI 2023 Conference paper, 01 Oct. 2023
      • Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.
        Naoko Shiba; Xiao Yang; Mitsuto Sato; Shin Kadota; Yota Suzuki; Masahiro Agata; Kohei Nagamine; Masaki Izumi; Yusuke Honda; Tomoya Koganehira; Hideki Kobayashi; Hajime Ichimura; Shinichiro Chuma; Junichi Nakai; Shugo Tohyama; Keiichi Fukuda; Daigo Miyazaki; Akinori Nakamura; Yuji Shiba
        Molecular therapy. Nucleic acids, 12 Dec. 2023
      • Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.
        Yuki Tanaka; Shin Kadota; Jian Zhao; Hideki Kobayashi; Satomi Okano; Masaki Izumi; Yusuke Honda; Hajime Ichimura; Naoko Shiba; Takeshi Uemura; Yuko Wada; Shinichiro Chuma; Tsutomu Nakada; Shugo Tohyama; Keiichi Fukuda; Mitsuhiko Yamada; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba
        Stem cell research & therapy, 07 Sep. 2023
      • Genomic stability of mouse spermatogonial stem cells in vitro
        Shinichiro Chuma; Mito Kanatsu-Shinohara; Ami Katanaya; Mihoko Hosokawa; Takashi Shinohara
        Scientific Reports, Dec. 2021, Peer-reviewed, Lead author
        Access this paper :
      • Genome-Wide Analysis of Differentially Expressed miRNAs and Their Associated Regulatory Networks in Lenses Deficient for the Congenital Cataract-Linked Tudor Domain Containing Protein TDRD7
        Deepti Anand; Salma Al Saai; Sanjaya K. Shrestha; Carrie E. Barnum; Shinichiro Chuma; Salil A. Lachke
        Frontiers in Cell and Developmental Biology, 16 Feb. 2021
      • The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
        Carrie E Barnum; Salma Al Saai; Shaili D Patel; Catherine Cheng; Deepti Anand; Xiaolu Xu; Soma Dash; Archana D Siddam; Lisa Glazewski; Emily Paglione; Shawn W Polson; Shinichiro Chuma; Robert W Mason; Shuo Wei; Mona Batish; Velia M Fowler; Salil A Lachke
        Human molecular genetics, 29 Jul. 2020
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      • Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
        Hajime Ichimura; Shin Kadota; Toshihide Kashihara; Mitsuhiko Yamada; Kuniaki Ito; Hideki Kobayashi; Yuki Tanaka; Naoko Shiba; Shinichiro Chuma; Shugo Tohyama; Tatsuichiro Seto; Kenji Okada; Koichiro Kuwahara; Yuji Shiba
        Scientific reports, 17 Jul. 2020
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      • Overexpression of Nuclear Receptor 5A1 Induces and Maintains an Intermediate State of Conversion between Primed and Naive Pluripotency.
        Kaori Yamauchi; Tatsuhiko Ikeda; Mihoko Hosokawa; Norio Nakatsuji; Eihachiro Kawase; Shinichiro Chuma; Kouichi Hasegawa; Hirofumi Suemori
        Stem cell reports, 10 Mar. 2020
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      • MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells.
        Kei-Ichiro Ishiguro; Kumi Matsuura; Naoki Tani; Naoki Takeda; Shingo Usuki; Mariko Yamane; Michihiko Sugimoto; Sayoko Fujimura; Mihoko Hosokawa; Shinichiro Chuma; Minoru S H Ko; Kimi Araki; Hitoshi Niwa
        Developmental cell, 24 Feb. 2020
      • GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice†.
        Yusuke Shiromoto; Satomi Kuramochi-Miyagawa; Ippei Nagamori; Shinichiro Chuma; Tatsuhiko Arakawa; Toru Nishimura; Hidetoshi Hasuwa; Taro Tachibana; Masahito Ikawa; Toru Nakano
        Biology of reproduction, 01 Jul. 2019
      • Mouse GTSF1 is an essential factor for secondary piRNA biogenesis.
        Takuji Yoshimura; Toshiaki Watanabe; Satomi Kuramochi-Miyagawa; Noriaki Takemoto; Yusuke Shiromoto; Akihiko Kudo; Masami Kanai-Azuma; Fumi Tashiro; Satsuki Miyazaki; Ami Katanaya; Shinichiro Chuma; Jun-Ichi Miyazaki
        EMBO reports, Apr. 2018
      • PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice.
        Ayako L Mochizuki; Ami Katanaya; Eri Hayashi; Mihoko Hosokawa; Emiko Moribe; Akira Motegi; Masamichi Ishiai; Minoru Takata; Gen Kondoh; Hitomi Watanabe; Norio Nakatsuji; Shinichiro Chuma
        Molecular and cellular biology, 01 Dec. 2017
      • Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes.
        Yuka Kabayama; Hidehiro Toh; Ami Katanaya; Takayuki Sakurai; Shinichiro Chuma; Satomi Kuramochi-Miyagawa; Yumiko Saga; Toru Nakano; Hiroyuki Sasaki
        Nucleic acids research, 19 May 2017
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      • Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells.
        Hiroki Inoue; Narumi Ogonuki; Michiko Hirose; Yuki Hatanaka; Shogo Matoba; Shinichiro Chuma; Kimio Kobayashi; Shigeharu Wakana; Junko Noguchi; Kimiko Inoue; Kentaro Tanemura; Atsuo Ogura
        Biochemical and biophysical research communications, 16 Sep. 2016
      • HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse.
        Tomoko Ichiyanagi; Kenji Ichiyanagi; Ayako Ogawa; Satomi Kuramochi-Miyagawa; Toru Nakano; Shinichiro Chuma; Hiroyuki Sasaki; Heiichiro Udono
        Nucleic acids research, 29 Oct. 2014
      • LINE-1 of evidence for fetal oocyte attrition by retrotransposon.
        Shinichiro Chuma
        Developmental cell, 09 Jun. 2014
      • Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
        Radha Raman Pandey; Yoshimi Tokuzawa; Zhaolin Yang; Eri Hayashi; Tomoko Ichisaka; Shimpei Kajita; Yuka Asano; Tetsuo Kunieda; Ravi Sachidanandam; Shinichiro Chuma; Shinya Yamanaka; Ramesh S Pillai
        Proceedings of the National Academy of Sciences of the United States of America, 08 Oct. 2013
      • The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles.
        Ai Khim Lim; Chanchao Lorthongpanich; Ting Gang Chew; Chin Wee Godwin Tan; Yan Ting Shue; Sathish Balu; Natalia Gounko; Satomi Kuramochi-Miyagawa; Martin M Matzuk; Shinichiro Chuma; Daniel M Messerschmidt; Davor Solter; Barbara B Knowles
        Development (Cambridge, England), Sep. 2013
      • GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells.
        Yusuke Shiromoto; Satomi Kuramochi-Miyagawa; Akito Daiba; Shinichiro Chuma; Ami Katanaya; Akiko Katsumata; Ken Nishimura; Manami Ohtaka; Mahito Nakanishi; Toshinobu Nakamura; Koichi Yoshinaga; Noriko Asada; Shota Nakamura; Teruo Yasunaga; Kanako Kojima-Kita; Daisuke Itou; Tohru Kimura; Toru Nakano
        RNA (New York, N.Y.), Jun. 2013
      • piRNA and spermatogenesis in mice.
        Shinichiro Chuma; Toru Nakano
        Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 05 Jan. 2013
      • A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing.
        Jordi Xiol; Elisa Cora; Rubina Koglgruber; Shinichiro Chuma; Sailakshmi Subramanian; Mihoko Hosokawa; Michael Reuter; Zhaolin Yang; Philipp Berninger; Andres Palencia; Vladimir Benes; Josef Penninger; Ravi Sachidanandam; Ramesh S Pillai
        Molecular cell, 28 Sep. 2012
      • Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing.
        Yuichi Morozumi; Ryohei Ino; Motoki Takaku; Mihoko Hosokawa; Shinichiro Chuma; Hitoshi Kurumizaka
        Nucleic acids research, Apr. 2012
      • piRNAs and their involvement in male germline development in mice.
        Ramesh S Pillai; Shinichiro Chuma
        Development, growth & differentiation, Jan. 2012
      • Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.
        Michael Reuter; Philipp Berninger; Shinichiro Chuma; Hardik Shah; Mihoko Hosokawa; Charlotta Funaya; Claude Antony; Ravi Sachidanandam; Ramesh S Pillai
        Nature, 27 Nov. 2011
      • Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.
        Takashi Tanaka; Mihoko Hosokawa; Vasily V Vagin; Michael Reuter; Eri Hayashi; Ayako L Mochizuki; Kouichi Kitamura; Hidenori Yamanaka; Gen Kondoh; Katsuya Okawa; Satomi Kuramochi-Miyagawa; Toru Nakano; Ravi Sachidanandam; Gregory J Hannon; Ramesh S Pillai; Norio Nakatsuji; Shinichiro Chuma
        Proceedings of the National Academy of Sciences of the United States of America, 28 Jun. 2011
      • MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.
        Toshiaki Watanabe; Shinichiro Chuma; Yasuhiro Yamamoto; Satomi Kuramochi-Miyagawa; Yasushi Totoki; Atsushi Toyoda; Yuko Hoki; Asao Fujiyama; Tatsuhiro Shibata; Takashi Sado; Toshiaki Noce; Toru Nakano; Norio Nakatsuji; Haifan Lin; Hiroyuki Sasaki
        Developmental cell, 15 Mar. 2011
      • TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
        Yukihiro Yabuta; Hiroshi Ohta; Takaya Abe; Kazuki Kurimoto; Shinichiro Chuma; Mitinori Saitou
        The Journal of cell biology, 07 Mar. 2011
      • MVH in piRNA processing and gene silencing of retrotransposons.
        Satomi Kuramochi-Miyagawa; Toshiaki Watanabe; Kengo Gotoh; Kana Takamatsu; Shinichiro Chuma; Kanako Kojima-Kita; Yusuke Shiromoto; Noriko Asada; Atsushi Toyoda; Asao Fujiyama; Yasushi Totoki; Tatsuhiro Shibata; Tohru Kimura; Norio Nakatsuji; Toshiaki Noce; Hiroyuki Sasaki; Toru Nakano
        Genes & development, May 2010
      • Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3.
        Masashi Yamaji; Takashi Tanaka; Mayo Shigeta; Shinichiro Chuma; Yumiko Saga; Mitinori Saitou
        Reproduction (Cambridge, England), Feb. 2010
      • Retrotransposon silencing by piRNAs: ping-pong players mark their sub-cellular boundaries.
        Shinichiro Chuma; Ramesh S Pillai
        PLoS genetics, Dec. 2009
      • The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
        Masanobu Shoji; Takashi Tanaka; Mihoko Hosokawa; Michael Reuter; Alexander Stark; Yuzuru Kato; Gen Kondoh; Katsuya Okawa; Takeshi Chujo; Tsutomu Suzuki; Kenichiro Hata; Sandra L Martin; Toshiaki Noce; Satomi Kuramochi-Miyagawa; Toru Nakano; Hiroyuki Sasaki; Ramesh S Pillai; Norio Nakatsuji; Shinichiro Chuma
        Developmental cell, Dec. 2009
      • Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells.
        Kanako Kojima; Satomi Kuramochi-Miyagawa; Shinichiro Chuma; Takashi Tanaka; Norio Nakatsuji; Tohru Kimura; Toru Nakano
        Genes to cells : devoted to molecular & cellular mechanisms, Oct. 2009
      • Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.
        Vasily V Vagin; James Wohlschlegel; Jun Qu; Zophonias Jonsson; Xinhua Huang; Shinichiro Chuma; Angelique Girard; Ravi Sachidanandam; Gregory J Hannon; Alexei A Aravin
        Genes & development, 01 Aug. 2009
      • Ultrastructural characterization of spermatogenesis and its evolutionary conservation in the germline: germinal granules in mammals.
        Shinichiro Chuma; Mihoko Hosokawa; Takashi Tanaka; Norio Nakatsuji
        Molecular and cellular endocrinology, 10 Jul. 2009
      • Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects.
        Seiji Takashima; Masanori Takehashi; Jiyoung Lee; Shinichiro Chuma; Masaki Okano; Kenichiro Hata; Isao Suetake; Norio Nakatsuji; Hiroyuki Miyoshi; Shoji Tajima; Yoriko Tanaka; Shinya Toyokuni; Hiroyuki Sasaki; Mito Kanatsu-Shinohara; Takashi Shinohara
        Biology of reproduction, Jul. 2009
      • Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile.
        Michael Reuter; Shinichiro Chuma; Takashi Tanaka; Thomas Franz; Alexander Stark; Ramesh S Pillai
        Nature structural & molecular biology, Jun. 2009
      • Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.
        Jianquan Wang; Jonathan P Saxe; Takashi Tanaka; Shinichiro Chuma; Haifan Lin
        Current biology : CB, 28 Apr. 2009
      • In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells.
        Kaori Yamauchi; Kouichi Hasegawa; Shinichiro Chuma; Norio Nakatsuji; Hirofumi Suemori
        PloS one, 2009
      • Production of transgenic rats via lentiviral transduction and xenogeneic transplantation of spermatogonial stem cells.
        Mito Kanatsu-Shinohara; Megumi Kato; Masanori Takehashi; Hiroko Morimoto; Seiji Takashima; Shinichiro Chuma; Norio Nakatsuji; Masumi Hirabayashi; Takashi Shinohara
        Biology of reproduction, Dec. 2008
      • Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin.
        Mito Kanatsu-Shinohara; Masanori Takehashi; Seiji Takashima; Jiyoung Lee; Hiroko Morimoto; Shinichiro Chuma; Aurelia Raducanu; Norio Nakatsuji; Reinhard Fässler; Takashi Shinohara
        Cell stem cell, 06 Nov. 2008
      • Long-term culture of male germline stem cells from hamster testes.
        Mito Kanatsu-Shinohara; Tomomi Muneto; Jiyoung Lee; Manami Takenaka; Shinichiro Chuma; Norio Nakatsuji; Toshitaka Horiuchi; Takashi Shinohara
        Biology of reproduction, Apr. 2008
      • Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice.
        Mihoko Hosokawa; Masanobu Shoji; Kouichi Kitamura; Takashi Tanaka; Toshiaki Noce; Shinichiro Chuma; Norio Nakatsuji
        Developmental biology, 01 Jan. 2007
      • Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice.
        Shinichiro Chuma; Mihoko Hosokawa; Kouichi Kitamura; Shinya Kasai; Makio Fujioka; Masateru Hiyoshi; Kazufumi Takamune; Toshiaki Noce; Norio Nakatsuji
        Proceedings of the National Academy of Sciences of the United States of America, 24 Oct. 2006
      • Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination.
        Takashi Shinohara; Megumi Kato; Masanori Takehashi; Jiyoung Lee; Shinichiro Chuma; Norio Nakatsuji; Mito Kanatsu-Shinohara; Masumi Hirabayashi
        Proceedings of the National Academy of Sciences of the United States of America, 12 Sep. 2006
      • Testatin transgenic and knockout mice exhibit normal sex-differentiation.
        Kouichi Hasegawa; Shinichiro Chuma; Takashi Tada; Takayuki Sakurai; Masaru Tamura; Hirofumi Suemori; Norio Nakatsuji
        Biochemical and biophysical research communications, 10 Mar. 2006
      • RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.
        Jieyan Pan; Mary Goodheart; Shinichiro Chuma; Norio Nakatsuji; David C Page; P Jeremy Wang
        Development (Cambridge, England), Sep. 2005
      • RNA interference during spermatogenesis in mice.
        Masanobu Shoji; Shinichiro Chuma; Kayo Yoshida; Takashi Morita; Norio Nakatsuji
        Developmental biology, 15 Jun. 2005
      • Genomic imprinting of XX spermatogonia and XX oocytes recovered from XX<-->XY chimeric testes.
        Ayako Isotani; Tomoko Nakanishi; Shin Kobayashi; Jiyoung Lee; Shinichiro Chuma; Norio Nakatsuji; Fumitoshi Ishino; Masaru Okabe
        Proceedings of the National Academy of Sciences of the United States of America, 15 Mar. 2005
      • Spermatogenesis from epiblast and primordial germ cells following transplantation into postnatal mouse testis.
        Shinichiro Chuma; Mito Kanatsu-Shinohara; Kimiko Inoue; Narumi Ogonuki; Hiromi Miki; Shinya Toyokuni; Mihoko Hosokawa; Norio Nakatsuji; Atsuo Ogura; Takashi Shinohara
        Development (Cambridge, England), Jan. 2005
      • Haploinsufficiency of Bcl-x leads to male-specific defects in fetal germ cells: differential regulation of germ cell apoptosis between the sexes.
        Shinya Kasai; Shinichiro Chuma; Noboru Motoyama; Norio Nakatsuji
        Developmental biology, 01 Dec. 2003
      • Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid bodies/nuages in male germ cells and forms a complex with snRNPs.
        Shinichiro Chuma; Masateru Hiyoshi; Akitsugu Yamamoto; Mihoko Hosokawa; Kazufumi Takamune; Norio Nakatsuji
        Mechanisms of development, Sep. 2003
      • Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1.
        M Tamura; Y Kanno; S Chuma; T Saito; N Nakatsuji
        Mechanisms of development, Apr. 2001
      • Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling.
        S Chuma; N Nakatsuji
        Developmental biology, 15 Jan. 2001
      • Differentiation of mouse primordial germ cells into female or male germ cells.
        N Nakatsuji; S Chuma
        The International journal of developmental biology, 2001
      • In vivo transfection of testicular germ cells and transgenesis by using the mitochondrially localized jellyfish fluorescent protein gene.
        Z Huang; M Tamura; T Sakurai; S Chuma; T Saito; N Nakatsuji
        FEBS letters, 29 Dec. 2000
      • A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation.
        Y Kanno; M Tamura; S Chuma; T Sakura; T Machida; N Nakatsuji
        The International journal of developmental biology, Nov. 1999

      Books and Other Publications

      • 減数分裂の発生制御とゲノム情報の継承、実験医学 32、853-858
        中馬新一郎
        2014
      • 哺乳類生殖細胞と生殖顆粒構造、生殖細胞の発生・エピジェネティクスと再プログラム化、蛋白質核酸酵素 52（共立出版）、 2102-2108
        中馬新一郎; 中辻憲夫
        2007
      • 多能性幹細胞と胚形成・生殖系列、 再生医学の基礎 幹細胞と臓器形成（名古屋大学出版会）、1-29
        中辻憲夫; 中馬新一郎
        2003
      • 始原生殖細胞の培養と減数分裂への移行、幹細胞クローン研究プロトコール（羊土社）、33-41
        中馬新一郎
        2001
      • 胎仔生殖系列細胞の発生と操作、遺伝子医学 4、264-268
        中馬新一郎; 中辻憲夫
        2000
      • 学会見聞記、蛋白質核酸酵素、６月、915-917
        中馬新一郎、田村勝、中辻憲夫
        1999

      Awards

      • May 2015
        日本発生生物学会, DGD Editor-in-Chief Prize
      • May 2013
        日本発生生物学会, DGD Wiley-Blackwell Prize

      External funds: Kakenhi

      • 初期発生軸に沿った幹細胞の増殖分化プログラムと遺伝的安定性の可塑性
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        中馬 新一郎
        From 30 Oct. 2020, To 31 Mar. 2022, Project Closed
        ゲノム;幹細胞;初期胚;発生;エピゲノム;初期発生;多能性幹細胞;細胞周期;遺伝;生殖;染色体
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05362/
      • Developmental regulation of genome stability in the germline stem cell cycle in mice
        Grant-in-Aid for Scientific Research (B)
        Basic Section 43060:System genome science-related
        Kyoto University
        Shinichiro Chuma
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        ゲノム;遺伝;発生;生殖;幹細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02429/
      • 生殖幹細胞の増殖分化転換と核ダイナミクス連携
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        中馬 新一郎
        From 01 Apr. 2013, To 31 Mar. 2014, Discontinued
        生殖;減数分裂;ゲノム;クロマチン;幹細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25125711/
      • Meiosis priming in the germline stem cell cycle in mice
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        SHINICHIRO CHUMA
        From 28 Jun. 2013, To 31 Mar. 2018, Project Closed
        生殖;幹細胞;ゲノム;エピゲノム;減数分裂;遺伝;発生;生殖細胞;多能性幹細胞;遺伝情報
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25112004/
      • Regulation of epigenome dynamics and regulation in germ cells
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        Takashi Shinohara
        From 28 Jun. 2013, To 31 Mar. 2018, Project Closed
        エピジェネティクス;精子形成;卵子形成;核移植;エピゲノム;生殖細胞;エピジェネティックス;発生・分化
        https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-25112001/
      • Regulatory network and chromatin dynamics of meiosis induction in the germline
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        SHINICHIRO CHUMA
        From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
        減数分裂;クロマチン;生殖細胞;生殖;ゲノム;エピゲノム;発生;シグナル伝達;組み換え
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24370089/
      • 生殖細胞の減数分裂に伴うゲノム制御転換とシグナル応答のシステム解析
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        中馬 新一郎
        From 01 Apr. 2011, To 31 Mar. 2013, Project Closed
        減数分裂;ゲノム;組み換え;生殖細胞;シグナル伝達;発生
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23114706/
      • Small RNA and epigenetic control of the tudor-piwi pathway in the germline
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Shinichiro CHUMA
        From 01 Apr. 2010, To 31 Mar. 2012, Project Closed
        生殖細胞;ゲノム;RNA;発生;トランスポゾン;トランスポ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22770210/
      • 生殖幹細胞の増殖から減数分裂移行を制御するシグナル伝達クロストーク
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        中馬 新一郎
        From 01 Apr. 2010, To 31 Mar. 2012, Project Closed
        生殖細胞;減数分裂;シグナル伝達;ゲノム;発生
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22019018/
      • Meiotic transition of germline stem cells and molecular regulation of homologous chromosome recombination
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Shinichiro CHUMA
        From 01 Apr. 2008, To 31 Mar. 2010, Project Closed
        生殖細胞;減数分裂;発生;ゲノム;相同組換え
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20770177/
      • Molecular analysis of germinal granules / nuagein the mouse germline
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        Norio NAKATSUJI
        From 01 Apr. 2008, To 31 Mar. 2013, Project Closed
        発生・分化;遺伝学;遺伝子;動物;バイオテクノロジー;発生分化
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20062004/
      • 哺乳類tudor関連遺伝子群の生殖細胞における機能の解析
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        中馬 新一郎
        From 01 Apr. 2005, To 31 Mar. 2007, Project Closed
        発生・分化;生殖細胞;オルガネラ;遺伝子;RNP
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17770191/
      • マウス生殖細胞の発生分化制御に関わる遺伝子機構の解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        中辻 憲夫
        From 01 Apr. 2003, To 31 Mar. 2008, Project Closed
        発生・分化;遺伝学;遺伝子;動物;バイオテクノロジー;生殖細胞;生殖顆粒;vasa;tudor;ES細胞;分化誘導;再プログラム化;核移植
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15080204/
      • 初期発生過程を起点とするDNA損傷の包括的データ計測と制御技術の探索
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        中馬 新一郎
        From 01 Apr. 2022, To 31 Mar. 2024, Declined
        ゲノム;変異;幹細胞;発生;遺伝;生殖
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04670/
      • genome stability for the next generation
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Kyoto University
        中馬 新一郎
        From 01 Apr. 2023, To 31 Mar. 2028, Granted
        生殖;幹細胞;ゲノム;変異;エピゲノム;精子形成;生殖細胞;次世代;霊長類
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23H04953/
      • Dynamic reproductive lifespan: Life-long changes and fluctuations in germ cell function and risk for next generation
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Institute of Physical and Chemical Research
        北島 智也
        From 01 Apr. 2023, To 31 Mar. 2028, Granted
        生殖;生殖細胞;染色体;ゲノム;遺伝
        https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-23H04947/

      External funds: others

      • 再生医療等の産業化に向けた評価基盤技術開発事業：ヒト多能性幹細胞由来の再生医療製品製造システムの開発
        AMED
        From Apr. 2014, To Mar. 2019
        中辻憲夫
      list
        Last Updated :2025/05/27

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          ILAS Seminar
          Z001, Spring, Institute for Liberal Arts and Sciences, 2
        • From Apr. 2015, To Mar. 2016
          Seminar on Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Introduction to Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        • From Apr. 2020, To Mar. 2021
          ILAS Seminar :Seminar on Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        list
          Last Updated :2025/05/27

          Administration

          School management (title, position)

          • From 01 Apr. 2013, To 31 Mar. 2015
            京都大学組み換えDNA実験安全委員会 委員
          • From 01 Apr. 2015, To 31 Mar. 2017
            組換えDNA実験安全委員会 1号委員
          • From 01 Apr. 2017, To 31 Mar. 2019
            組換えDNA実験安全委員会 1号委員
          • From 01 Apr. 2019, To 31 Mar. 2021
            組換えＤＮＡ実験安全委員会 委員
          • From 01 Apr. 2021, To 31 Mar. 2023
            組換えＤＮＡ実験安全委員会 委員
          • From 01 Apr. 2023, To 31 Mar. 2025
            組換えＤＮＡ実験安全委員会 委員

          Faculty management (title, position)

          • From 01 Apr. 2023, To 31 Mar. 2024
            広報委員会　委員
          • From 01 Apr. 2023
            共同利用機器等委員会　委員
          • From 01 Jul. 2021
            再生実験動物施設飼育室施設運営委員会 委員
          • From 01 Oct. 2016
            ヒトES細胞株樹立・分配事業検討委員会　委員
          • 20210701
          • From 01 Oct. 2016
            化学物質管理委員会　委員
          • From 01 Oct. 2018, To 31 Mar. 2021
            兼業・利益相反審査委員会
          • 安全衛生委員会　委員
          • From 01 Oct. 2016, To 30 Jun. 2021
            再生医科学動物実験専門委員会　委員

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