Basic Information

Professional Memberships

• From Apr. 2022, To Present

  Protein Science Society of Japan

Academic Degree

• Master (Agriculture) (The University of Tokyo)
• Ph.D. (Agriculture) (The University of Tokyo)

Academic Resume (Graduate Schools)

• The University of Tokyo, Graduate School of Agricultural and Life Science, Department of Biotechnology, Completion
• The University of Tokyo, Graduate School of Agricultural and Life Science, Department of Biotechnology, Completion

Academic Resume (Undergraduate School/Majors)

• Korea University, College of Science & Technology, Department of Food and Biotechnology, Graduated

Research History

• From Aug. 2020, To Present

  Kyoto University, Graduate School of Medicine, 助教
• From Apr. 2018, To Jul. 2020

  Otsuka Pharmaceutical Co., Ltd., 創薬化学研究所, 研究員
• From Apr. 2013, To Mar. 2018

  Kyoto University, Graduate School of Medicine, 特定研究員

Language of Instruction

• English
• Japanese
• Korean

ID,URL

• J-Global ID

  201401080028873303

Research

Research Interests

• Structural Biology
• GPCR
• Dopamin receptor
• Histamine receptor
• Neurotransmitter
• Membrane protein
• SBDD

Research Areas

• Life sciences, Medical biochemistry
• Life sciences, Neuroscience - general
• Life sciences, Structural biochemistry

Papers

• Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor.

  Dohyun Im; Jun-Ichi Kishikawa; Yuki Shiimura; Hiromi Hisano; Akane Ito; Yoko Fujita-Fujiharu; Yukihiko Sugita; Takeshi Noda; Takayuki Kato; Hidetsugu Asada; So Iwata

  Nature communications, 20 Oct. 2023, Peer-reviewed, Lead author

  
• Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography

  Alexander M. Wolff; Eriko Nango; Iris D. Young; Aaron S. Brewster; Minoru Kubo; Takashi Nomura; Michihiro Sugahara; Shigeki Owada; Benjamin A. Barad; Kazutaka Ito; Asmit Bhowmick; Sergio Carbajo; Tomoya Hino; James M. Holton; Dohyun Im; Lee J. O’Riordan; Tomoyuki Tanaka; Rie Tanaka; Raymond G. Sierra; Fumiaki Yumoto; Kensuke Tono; So Iwata; Nicholas K. Sauter; James S. Fraser; Michael C. Thompson

  Nature Chemistry, 18 Sep. 2023, Peer-reviewed

  
• Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.

  Hidetsugu Asada; Dohyun Im; Yunhon Hotta; Satoshi Yasuda; Takeshi Murata; Ryoji Suno; So Iwata

  Structure (London, England : 1993), 01 Dec. 2022, Peer-reviewed

  
• S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.

  Masayasu Toyomoto; Asuka Inoue; Kei Iida; Masatsugu Denawa; Isao Kii; Francois Marie Ngako Kadji; Takayuki Kishi; Dohyun Im; Tatsuro Shimamura; Hiroshi Onogi; Suguru Yoshida; So Iwata; Junken Aoki; Takamitsu Hosoya; Masatoshi Hagiwara

  Cell chemical biology, 19 Aug. 2021, Peer-reviewed

  
• Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone.

  Dohyun Im; Asuka Inoue; Takaaki Fujiwara; Takanori Nakane; Yasuaki Yamanaka; Tomoko Uemura; Chihiro Mori; Yuki Shiimura; Kanako Terakado Kimura; Hidetsugu Asada; Norimichi Nomura; Tomoyuki Tanaka; Ayumi Yamashita; Eriko Nango; Kensuke Tono; Francois Marie Ngako Kadji; Junken Aoki; So Iwata; Tatsuro Shimamura

  Nature communications, 22 Dec. 2020, Peer-reviewed, Lead author

  
• The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.

  Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Kunio Hirata; Yuki Shiimura; Dohyun Im; Tatsuro Shimamura; Norimichi Nomura; Hiroko Iwanari; Takao Hamakubo; Osamu Kusano-Arai; Hiromi Hisano; Tomoko Uemura; Chiyo Suno; Junken Aoki; So Iwata

  Structure (London, England : 1993), 07 Apr. 2020, Peer-reviewed

  
• Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.

  Alexander M Wolff; Iris D Young; Raymond G Sierra; Aaron S Brewster; Michael W Martynowycz; Eriko Nango; Michihiro Sugahara; Takanori Nakane; Kazutaka Ito; Andrew Aquila; Asmit Bhowmick; Justin T Biel; Sergio Carbajo; Aina E Cohen; Saul Cortez; Ana Gonzalez; Tomoya Hino; Dohyun Im; Jake D Koralek; Minoru Kubo; Tomas S Lazarou; Takashi Nomura; Shigeki Owada; Avi J Samelson; Tomoyuki Tanaka; Rie Tanaka; Erin M Thompson; Henry van den Bedem; Rahel A Woldeyes; Fumiaki Yumoto; Wei Zhao; Kensuke Tono; Sebastien Boutet; So Iwata; Tamir Gonen; Nicholas K Sauter; James S Fraser; Michael C Thompson

  IUCrJ, 01 Mar. 2020, Peer-reviewed

  
• Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine.

  Kanako Terakado Kimura; Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Dohyun Im; Chihiro Mori; Takatoshi Arakawa; Kunio Hirata; Yayoi Nomura; Norimichi Nomura; Junken Aoki; So Iwata; Tatsuro Shimamura

  Nature structural & molecular biology, Feb. 2019, Peer-reviewed

  
• Ligand complex structures of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813 and its conformational change.

  Dohyun Im; Daisuke Matsui; Takatoshi Arakawa; Kimiyasu Isobe; Yasuhisa Asano; Shinya Fushinobu

  FEBS open bio, Mar. 2018, Peer-reviewed, Lead author

  
• Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.

  Ryoji Suno; Kanako Terakado Kimura; Takanori Nakane; Keitaro Yamashita; Junmei Wang; Takaaki Fujiwara; Yasuaki Yamanaka; Dohyun Im; Shoichiro Horita; Hirokazu Tsujimoto; Maki S Tawaramoto; Takatsugu Hirokawa; Eriko Nango; Kensuke Tono; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Makina Yabashi; Keiko Shimamoto; Masaki Yamamoto; Daniel M Rosenbaum; So Iwata; Tatsuro Shimamura; Takuya Kobayashi

  Structure (London, England : 1993), 02 Jan. 2018, Peer-reviewed

  
• A three-dimensional movie of structural changes in bacteriorhodopsin.

  Eriko Nango; Antoine Royant; Minoru Kubo; Takanori Nakane; Cecilia Wickstrand; Tetsunari Kimura; Tomoyuki Tanaka; Kensuke Tono; Changyong Song; Rie Tanaka; Toshi Arima; Ayumi Yamashita; Jun Kobayashi; Toshiaki Hosaka; Eiichi Mizohata; Przemyslaw Nogly; Michihiro Sugahara; Daewoong Nam; Takashi Nomura; Tatsuro Shimamura; Dohyun Im; Takaaki Fujiwara; Yasuaki Yamanaka; Byeonghyun Jeon; Tomohiro Nishizawa; Kazumasa Oda; Masahiro Fukuda; Rebecka Andersson; Petra Båth; Robert Dods; Jan Davidsson; Shigeru Matsuoka; Satoshi Kawatake; Michio Murata; Osamu Nureki; Shigeki Owada; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Gebhard Schertler; Makina Yabashi; Ana-Nicoleta Bondar; Jörg Standfuss; Richard Neutze; So Iwata

  Science (New York, N.Y.), 23 Dec. 2016, Peer-reviewed

  
• Mutational and crystallographic analysis of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813: Interconversion between oxidase and monooxygenase activities.

  Daisuke Matsui; Do-Hyun Im; Asami Sugawara; Yasuhisa Fukuta; Shinya Fushinobu; Kimiyasu Isobe; Yasuhisa Asano

  FEBS open bio, 2014, Peer-reviewed, Lead author

  
• Crystal structures of glycoside hydrolase family 51 α-L-arabinofuranosidase from Thermotoga maritima.

  Do-Hyun Im; Kei-ichi Kimura; Fumitaka Hayasaka; Tomonari Tanaka; Masato Noguchi; Atsushi Kobayashi; Shin-ichiro Shoda; Kentaro Miyazaki; Takayoshi Wakagi; Shinya Fushinobu

  Bioscience, biotechnology, and biochemistry, 2012, Peer-reviewed, Lead author

  

External funds: Kakenhi

• A new mechanism of drug selectivity for dopamine receptor

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48030:Pharmacology-related

  Kyoto University

  林 到ヒョン

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  GPCR;創薬;ドパミン受容体;Cryo-EM;SBDD

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06357/
• Structural Study of Human Dopamine D2 Receptor

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Dohyun Im

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  Gタンパク質共役受容体;GPCR;X線結晶構造解析;膜タンパク質;膜蛋白質;神経伝達物質・受容体;結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18376/