Basic Information

Professional Memberships

• From Apr. 2024, To Present

  日本生物物理学会
• From Apr. 2022, To Present

  Protein Science Society of Japan

Academic Degree

• Master (Agriculture) (The University of Tokyo)
• Ph.D. (Agriculture) (The University of Tokyo)

Academic Resume (Graduate Schools)

• The University of Tokyo, Graduate School of Agricultural and Life Science, Department of Biotechnology, Completion
• The University of Tokyo, Graduate School of Agricultural and Life Science, Department of Biotechnology, Completion

Research History

• From Aug. 2020, To Present

  Kyoto University, Graduate School of Medicine, 助教
• From Apr. 2018, To Jul. 2020

  Otsuka Pharmaceutical Co., Ltd., 創薬化学研究所, 研究員
• From Apr. 2013, To Mar. 2018

  Kyoto University, Graduate School of Medicine, 特定研究員

Language of Instruction

• English
• Japanese
• Korean

ID,URL

• J-Global ID

  201401080028873303

Research

Research Interests

• Structural Biology
• GPCR
• Dopamin receptor
• Histamine receptor
• Neurotransmitter
• Membrane protein
• SBDD

Research Areas

• Life sciences, Medical biochemistry
• Life sciences, Neuroscience - general
• Life sciences, Structural biochemistry

Papers

• Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel

  Young-Woo Nam; Dohyun Im; Ana Santa Cruz Garcia; Marios L. Tringides; Hai Minh Nguyen; Yan Liu; Razan Orfali; Alena Ramanishka; Grigore Pintilie; Chih-Chia Su; Meng Cui; Diomedes E. Logothetis; Edward W. Yu; Heike Wulff; K. George Chandy; Miao Zhang

  Nature Communications, 17 Apr. 2025

  
• The structure and function of the ghrelin receptor coding for drug actions.

  Yuki Shiimura; Dohyun Im; Ryosuke Tany; Hidetsugu Asada; Ryoji Kise; Eon Kurumiya; Hideko Wakasugi-Masuho; Satoshi Yasuda; Kazuma Matsui; Jun-Ichi Kishikawa; Takayuki Kato; Takeshi Murata; Masayasu Kojima; So Iwata; Ikuo Masuho

  Nature structural & molecular biology, 20 Jan. 2025

  
• Neurotransmitter recognition by human vesicular monoamine transporter 2.

  Dohyun Im; Mika Jormakka; Narinobu Juge; Jun-Ichi Kishikawa; Takayuki Kato; Yukihiko Sugita; Takeshi Noda; Tomoko Uemura; Yuki Shiimura; Takaaki Miyaji; Hidetsugu Asada; So Iwata

  Nature communications, 16 Sep. 2024

  Access this paper :

  
• Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor.

  Tsuyoshi Araya; Yuya Matsuba; Harufumi Suzuki; Tomohiro Doura; Nipawan Nuemket; Eriko Nango; Masaki Yamamoto; Dohyun Im; Hidetsugu Asada; Shigeki Kiyonaka; So Iwata

  Biochemical and biophysical research communications, 05 Feb. 2024, Peer-reviewed

  
• Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor.

  Dohyun Im; Jun-Ichi Kishikawa; Yuki Shiimura; Hiromi Hisano; Akane Ito; Yoko Fujita-Fujiharu; Yukihiko Sugita; Takeshi Noda; Takayuki Kato; Hidetsugu Asada; So Iwata

  Nature communications, 20 Oct. 2023, Peer-reviewed, Lead author

  Access this paper :

  
• Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography

  Alexander M. Wolff; Eriko Nango; Iris D. Young; Aaron S. Brewster; Minoru Kubo; Takashi Nomura; Michihiro Sugahara; Shigeki Owada; Benjamin A. Barad; Kazutaka Ito; Asmit Bhowmick; Sergio Carbajo; Tomoya Hino; James M. Holton; Dohyun Im; Lee J. O’Riordan; Tomoyuki Tanaka; Rie Tanaka; Raymond G. Sierra; Fumiaki Yumoto; Kensuke Tono; So Iwata; Nicholas K. Sauter; James S. Fraser; Michael C. Thompson

  Nature Chemistry, 18 Sep. 2023, Peer-reviewed

  Access this paper :

  
• Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.

  Hidetsugu Asada; Dohyun Im; Yunhon Hotta; Satoshi Yasuda; Takeshi Murata; Ryoji Suno; So Iwata

  Structure (London, England : 1993), 01 Dec. 2022, Peer-reviewed

  
• S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.

  Masayasu Toyomoto; Asuka Inoue; Kei Iida; Masatsugu Denawa; Isao Kii; Francois Marie Ngako Kadji; Takayuki Kishi; Dohyun Im; Tatsuro Shimamura; Hiroshi Onogi; Suguru Yoshida; So Iwata; Junken Aoki; Takamitsu Hosoya; Masatoshi Hagiwara

  Cell chemical biology, 19 Aug. 2021, Peer-reviewed

  
• Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone.

  Dohyun Im; Asuka Inoue; Takaaki Fujiwara; Takanori Nakane; Yasuaki Yamanaka; Tomoko Uemura; Chihiro Mori; Yuki Shiimura; Kanako Terakado Kimura; Hidetsugu Asada; Norimichi Nomura; Tomoyuki Tanaka; Ayumi Yamashita; Eriko Nango; Kensuke Tono; Francois Marie Ngako Kadji; Junken Aoki; So Iwata; Tatsuro Shimamura

  Nature communications, 22 Dec. 2020, Peer-reviewed, Lead author

  Access this paper :

  
• The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.

  Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Kunio Hirata; Yuki Shiimura; Dohyun Im; Tatsuro Shimamura; Norimichi Nomura; Hiroko Iwanari; Takao Hamakubo; Osamu Kusano-Arai; Hiromi Hisano; Tomoko Uemura; Chiyo Suno; Junken Aoki; So Iwata

  Structure (London, England : 1993), 07 Apr. 2020, Peer-reviewed

  
• Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.

  Alexander M Wolff; Iris D Young; Raymond G Sierra; Aaron S Brewster; Michael W Martynowycz; Eriko Nango; Michihiro Sugahara; Takanori Nakane; Kazutaka Ito; Andrew Aquila; Asmit Bhowmick; Justin T Biel; Sergio Carbajo; Aina E Cohen; Saul Cortez; Ana Gonzalez; Tomoya Hino; Dohyun Im; Jake D Koralek; Minoru Kubo; Tomas S Lazarou; Takashi Nomura; Shigeki Owada; Avi J Samelson; Tomoyuki Tanaka; Rie Tanaka; Erin M Thompson; Henry van den Bedem; Rahel A Woldeyes; Fumiaki Yumoto; Wei Zhao; Kensuke Tono; Sebastien Boutet; So Iwata; Tamir Gonen; Nicholas K Sauter; James S Fraser; Michael C Thompson

  IUCrJ, 01 Mar. 2020, Peer-reviewed

  
• Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine.

  Kanako Terakado Kimura; Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Dohyun Im; Chihiro Mori; Takatoshi Arakawa; Kunio Hirata; Yayoi Nomura; Norimichi Nomura; Junken Aoki; So Iwata; Tatsuro Shimamura

  Nature structural & molecular biology, Feb. 2019, Peer-reviewed

  
• Ligand complex structures of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813 and its conformational change.

  Dohyun Im; Daisuke Matsui; Takatoshi Arakawa; Kimiyasu Isobe; Yasuhisa Asano; Shinya Fushinobu

  FEBS open bio, Mar. 2018, Peer-reviewed, Lead author

  
• Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.

  Ryoji Suno; Kanako Terakado Kimura; Takanori Nakane; Keitaro Yamashita; Junmei Wang; Takaaki Fujiwara; Yasuaki Yamanaka; Dohyun Im; Shoichiro Horita; Hirokazu Tsujimoto; Maki S Tawaramoto; Takatsugu Hirokawa; Eriko Nango; Kensuke Tono; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Makina Yabashi; Keiko Shimamoto; Masaki Yamamoto; Daniel M Rosenbaum; So Iwata; Tatsuro Shimamura; Takuya Kobayashi

  Structure (London, England : 1993), 02 Jan. 2018, Peer-reviewed

  
• A three-dimensional movie of structural changes in bacteriorhodopsin.

  Eriko Nango; Antoine Royant; Minoru Kubo; Takanori Nakane; Cecilia Wickstrand; Tetsunari Kimura; Tomoyuki Tanaka; Kensuke Tono; Changyong Song; Rie Tanaka; Toshi Arima; Ayumi Yamashita; Jun Kobayashi; Toshiaki Hosaka; Eiichi Mizohata; Przemyslaw Nogly; Michihiro Sugahara; Daewoong Nam; Takashi Nomura; Tatsuro Shimamura; Dohyun Im; Takaaki Fujiwara; Yasuaki Yamanaka; Byeonghyun Jeon; Tomohiro Nishizawa; Kazumasa Oda; Masahiro Fukuda; Rebecka Andersson; Petra Båth; Robert Dods; Jan Davidsson; Shigeru Matsuoka; Satoshi Kawatake; Michio Murata; Osamu Nureki; Shigeki Owada; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Gebhard Schertler; Makina Yabashi; Ana-Nicoleta Bondar; Jörg Standfuss; Richard Neutze; So Iwata

  Science (New York, N.Y.), 23 Dec. 2016, Peer-reviewed

  
• Mutational and crystallographic analysis of l-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813: Interconversion between oxidase and monooxygenase activities.

  Daisuke Matsui; Do-Hyun Im; Asami Sugawara; Yasuhisa Fukuta; Shinya Fushinobu; Kimiyasu Isobe; Yasuhisa Asano

  FEBS open bio, 2014, Peer-reviewed, Lead author

  
• Crystal structures of glycoside hydrolase family 51 α-L-arabinofuranosidase from Thermotoga maritima.

  Do-Hyun Im; Kei-ichi Kimura; Fumitaka Hayasaka; Tomonari Tanaka; Masato Noguchi; Atsushi Kobayashi; Shin-ichiro Shoda; Kentaro Miyazaki; Takayoshi Wakagi; Shinya Fushinobu

  Bioscience, biotechnology, and biochemistry, 2012, Peer-reviewed, Lead author

  

Misc.

• 肥満における5G(GLP-1、GIP、Glucagon、Ghrelin、Gut hormone) 基礎研究と臨床研究 グレリン受容体の構造的洞察(The 5Gs in Obesity(GLP-1, GIP, Glucagon, Ghrelin and Gut hormone): Basic and Clinical Research Structural Insights into Ghrelin Receptor)

  椎村 祐樹; Im Dohyun; Tany Ryosuke; Asada Hidetsugu; Matsui Kazuma; Masuho Ikuo; Iwata So; Kojima Masayasu

  肥満研究, Nov. 2023

  
• 生理活性物質アンジオテンシンIIの結合によるアンジオテンシンII受容体活性化機構の構造基盤

  浅田 秀基; 井上 飛鳥; Francois Kadji M.N.; 平田 邦生; 椎村 祐樹; Dohyun Im; 青木 淳賢; 岩田 想

  日本生化学会大会プログラム・講演要旨集, Sep. 2019

  
• Structural insights into ghrelin receptor

  椎村祐樹; 椎村祐樹; IM Dohyun; 浅田秀基; 松井一真; 岩田想; 児島将康

  日本薬学会年会要旨集(Web), 2024

  
• 機能性抗体を用いたアゴニスト結合型アデノシンA2a受容体の結晶構造解析

  IM Do-Hyun; IM Do-Hyun; 小笠原諭; 田中良樹; 寿野千代; 寿野千代; 日野智也; 村田武士; 岩田想; 岩田想; 島村達郎; 島村達郎

  GPCR研究会プログラム・抄録集, 2015

  

External funds: Kakenhi

• A new mechanism of drug selectivity for dopamine receptor

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48030:Pharmacology-related

  Kyoto University

  林 到ヒョン

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  GPCR;創薬;ドパミン受容体;Cryo-EM;SBDD

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06357/
• Structural Study of Human Dopamine D2 Receptor

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Dohyun Im

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  Gタンパク質共役受容体;GPCR;X線結晶構造解析;膜タンパク質;膜蛋白質;神経伝達物質・受容体;結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18376/
• 膜蛋白質のクライオ電子顕微鏡システマティック解析を可能にするアプローチ

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  岩田 想

  From 28 Jun. 2024, To 31 Mar. 2026, Granted

  クライオ電子顕微鏡;構造生物学;膜タンパク質;創薬;抗体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21945/