Basic Information

Professional Memberships

• International Cytokine and Interferon Society
• THE JAPANESE SOCIETY FOR IMMUNOLOGY

Academic Degree

• 博士（医学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程病理系専攻, 修了

ID,URL

• J-Global ID

  201501036535649880

researchmap URL

• https://researchmap.jp/7000011838

Research

Research Topics, Overview of the research

• Research Topics

  Immunological self-tolerance, Molecular basis of development and function of inflammatory T helper cells

Research Interests

• Th17 cells
• Autoimmune arthritis

Research Areas

• Life sciences, Immunology

Papers

• Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells

  Daiya Ohara; Yusuke Takeuchi; Keiji Hirota

  Cellular & Molecular Immunology, 08 Oct. 2024, Peer-reviewed, Invited

  
• Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity

  Domnica Luca; Sumin Lee; Keiji Hirota; Yasutaka Okabe; Junji Uehori; Kazushi Izawa; Anna-Lisa Lanz; Verena Schütte; Burcu Sivri; Yuta Tsukamoto; Fabian Hauck; Rayk Behrendt; Axel Roers; Takashi Fujita; Ryuta Nishikomori; Min Ae Lee-Kirsch; Hiroki Kato

  Science Advances, Mar. 2024

  
• Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice.

  Daiya Ohara; Yusuke Takeuchi; Hitomi Watanabe; Yoonha Lee; Hiroki Mukoyama; Toshiaki Ohteki; Gen Kondoh; Keiji Hirota

  The Journal of experimental medicine, 05 Feb. 2024

  Access this paper :

  
• Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition.

  By Yukiko Tokifuji; Hodaka Hayabuchi; Takashi Sasaki; Mariko Hara-Chikuma; Keiji Hirota; Hayato Takahashi; Masayuki Amagai; Akihiko Yoshimura; Shunsuke Chikuma

  iScience, 19 Jan. 2024

  
• Identification of Surface Markers and Functional Characterization of Myeloid Derived Suppressor Cell-Like Adherent Cells.

  John Clyde Co Soriano; Shiho Tsutsumi; Daiya Ohara; Keiji Hirota; Gen Kondoh; Tatsuya Niwa; Hideki Taguchi; Tetsuya Kadonosono; Shinae Kizaka-Kondoh

  Advanced biology, 20 Nov. 2023

  
• Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model

  Sumin Lee; Keiji Hirota; Verena Schuette; Takashi Fujita; Hiroki Kato

  Biochemical and Biophysical Research Communications, Nov. 2022, Peer-reviewed

  Access this paper :

  
• Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease.

  Atsushi Tanaka; Shinji Maeda; Takashi Nomura; Mara Anais Llamas-Covarrubias; Satoshi Tanaka; Lin Jin; Ee Lyn Lim; Hiromasa Morikawa; Yohko Kitagawa; Shuji Akizuki; Yoshinaga Ito; Chihiro Fujimori; Keiji Hirota; Tosei Murase; Motomu Hashimoto; Junichi Higo; Rose Zamoyska; Ryuzo Ueda; Daron M Standley; Noriko Sakaguchi; Shimon Sakaguchi

  The Journal of experimental medicine, 06 Feb. 2023

  
• Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity.

  Mirei Shirakashi; Mikako Maruya; Keiji Hirota; Tatsuaki Tsuruyama; Takashi Matsuo; Ryu Watanabe; Koichi Murata; Masao Tanaka; Hiromu Ito; Hajime Yoshifuji; Koichiro Ohmura; Dirk Elewaut; Shimon Sakaguchi; Sidonia Fagarasan; Tsuneyo Mimori; Motomu Hashimoto

  Arthritis & rheumatology (Hoboken, N.J.), Apr. 2022

  
• Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis.

  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Noriko Sakaguchi; Shimon Sakaguchi; Gen Kondoh; Akio Morinobu; Tsuneyo Mimori; Keiji Hirota

  Scientific reports, 21 Sep. 2021

  Access this paper :

  
• Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

  Ryoji Kawakami; Yohko Kitagawa; Kelvin Y. Chen; Masaya Arai; Daiya Ohara; Yamami Nakamura; Keiko Yasuda; Motonao Osaki; Norihisa Mikami; Caleb A. Lareau; Hitomi Watanabe; Gen Kondoh; Keiji Hirota; Naganari Ohkura; Shimon Sakaguchi

  Immunity, May 2021, Peer-reviewed

  
• Foxp3+ Regulatory T Cells Inhibit CCl4-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity

  Yoshinobu Ikeno; Daiya Ohara; Yusuke Takeuchi; Hitomi Watanabe; Gen Kondoh; Kojiro Taura; Shinji Uemoto; Keiji Hirota

  Frontiers in Immunology, 15 Oct. 2020, Peer-reviewed, Last author, Corresponding author

  
• Impaired T cell receptor signaling and development of T cell-mediated autoimmune arthritis.

  Yusuke Takeuchi; Keiji Hirota; Shimon Sakaguchi

  Immunological reviews, Mar. 2020, Peer-reviewed

  
• Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19.

  Masahiko Akamatsu; Norihisa Mikami; Naganari Ohkura; Ryoji Kawakami; Yohko Kitagawa; Atsushi Sugimoto; Keiji Hirota; Naoto Nakamura; Satoru Ujihara; Toshio Kurosaki; Hisao Hamaguchi; Hironori Harada; Guliang Xia; Yoshiaki Morita; Ichiro Aramori; Shuh Narumiya; Shimon Sakaguchi

  Science immunology, 25 Oct. 2019, Peer-reviewed

  
• Synovial Tissue Inflammation Mediated by Autoimmune T Cells.

  Takeuchi Y; Hirota K; Sakaguchi S

  Frontiers in immunology, Aug. 2019, Peer-reviewed

  Access this paper :

  
• Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection.

  Miki Arai Hojo; Kyoko Masuda; Hiroaki Hojo; Yosuke Nagahata; Keiko Yasuda; Daiya Ohara; Yusuke Takeuchi; Keiji Hirota; Yutaka Suzuki; Hiroshi Kawamoto; Shinpei Kawaoka

  Nature communications, 13 Jun. 2019, Peer-reviewed

  Access this paper :

  
• Correction to: The pathogenicity of Th17 cells in autoimmune diseases.

  Yasuda K; Takeuchi Y; Hirota K

  Seminars in immunopathology, May 2019, Peer-reviewed

  
• The pathogenicity of Th17 cells in autoimmune diseases.

  Yasuda K; Takeuchi Y; Hirota K

  Seminars in immunopathology, May 2019, Peer-reviewed

  
• Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.

  Yasuda K; Kitagawa Y; Kawakami R; Isaka Y; Watanabe H; Kondoh G; Kohwi-Shigematsu T; Sakaguchi S; Hirota K

  Nature communications, Feb. 2019, Peer-reviewed

  
• Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

  Keiji Hirota; Motomu Hashimoto; Yoshinaga Ito; Mayumi Matsuura; Hiromu Ito; Masao Tanaka; Hitomi Watanabe; Gen Kondoh; Atsushi Tanaka; Keiko Yasuda; Manfred Kopf; Alexandre J Potocnik; Brigitta Stockinger; Noriko Sakaguchi; Shimon Sakaguchi

  Immunity, 19 Jun. 2018, Peer-reviewed

  
• Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment (vol 18, pg 173, 2017)

  Yohko Kitagawa; Naganari Ohkura; Yujiro Kidani; Alexis Vandenbon; Keiji Hirota; Ryoji Kawakami; Keiko Yasuda; Daisuke Motooka; Shota Nakamura; Motonari Kondo; Ichiro Taniuchi; Terumi Kohwi-Shigematsu; Shimon Sakaguchi

  NATURE IMMUNOLOGY, Nov. 2017, Peer-reviewed

  
• Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor

  Marta Miralles; Herena Eixarch; Marcos Tejero; Carme Costa; Keiji Hirota; A. Raul Castano; Meritxell Puig; Gitta Stockinger; Xavier Montalban; Assumpcio Bosch; Carmen Espejo; Miguel Chillon

  NEUROTHERAPEUTICS, Oct. 2017, Peer-reviewed

  
• Lipid raft dynamics linked to sperm competency for fertilization in mice

  Hitomi Watanabe; Rie Takeda; Keiji Hirota; Gen Kondoh

  GENES TO CELLS, May 2017, Peer-reviewed

  
• Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

  Yohko Kitagawa; Naganari Ohkura; Yujiro Kidani; Alexis Vandenbon; Keiji Hirota; Ryoji Kawakami; Keiko Yasuda; Daisuke Motooka; Shota Nakamura; Motonari Kondo; Ichiro Taniuchi; Terumi Kohwi-Shigematsu; Shimon Sakaguchi

  Nature immunology, 22 Mar. 2017

  
• Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

  Yohko Kitagawa; Naganari Ohkura; Yujiro Kidani; Alexis Vandenbon; Keiji Hirota; Ryoji Kawakami; Keiko Yasuda; Daisuke Motooka; Shota Nakamura; Motonari Kondo; Ichiro Taniuchi; Terumi Kohwi-Shigematsu; Shimon Sakaguchi

  NATURE IMMUNOLOGY, Feb. 2017, Peer-reviewed

  
• Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

  Yuichi Maeda; Takashi Kurakawa; Eiji Umemoto; Daisuke Motooka; Yoshinaga Ito; Kazuyoshi Gotoh; Keiji Hirota; Masato Matsushita; Yoki Furuta; Masashi Narazaki; Noriko Sakaguchi; Hisako Kayama; Shota Nakamura; Tetsuya Iida; Yukihiko Saeki; Atsushi Kumanogoh; Shimon Sakaguchi; Kiyoshi Takeda

  ARTHRITIS & RHEUMATOLOGY, Nov. 2016, Peer-reviewed

  
• Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease

  Yoshinaga Ito; Motomu Hashimoto; Keiji Hirota; Naganari Ohkura; Hiromasa Morikawa; Hiroyoshi Nishikawa; Atsushi Tanaka; Moritoshi Furu; Hiromu Ito; Takao Fujii; Takashi Nomura; Sayuri Yamazaki; Akimichi Morita; Dario A. A. Vignali; John W. Kappler; Shuichi Matsuda; Tsuneyo Mimori; Noriko Sakaguchi; Shimon Sakaguchi

  SCIENCE, Oct. 2014, Peer-reviewed

  
• Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions

  Paola Di Meglio; Joao H. Duarte; Helena Ahlfors; Nick D. L. Owens; Ying Li; Federica Villanova; Isabella Tosi; Keiji Hirota; Frank O. Nestle; Ulrich Mrowietz; Michael J. Gilchrist; Brigitta Stockinger

  IMMUNITY, Jun. 2014, Peer-reviewed

  
• Differential Influences of the Aryl Hydrocarbon Receptor on Th17 Mediated Responses in vitro and in vivo

  Joao H. Duarte; Paola Di Meglio; Keiji Hirota; Helena Ahlfors; Brigitta Stockinger

  PLOS ONE, Nov. 2013, Peer-reviewed

  
• T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis.

  Hirota K; Hashimoto M; Yoshitomi H; Tanaka S; Nomura T; Yamaguchi T; Iwakura Y; Sakaguchi N; Sakaguchi S

  J Exp Med. 2007 Jan 22;204(1):41-7., 18 Jul. 2013, Peer-reviewed

  
• Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.

  Hirota K; Yoshitomi H; Hashimoto M; Maeda S; Teradaira S; Sugimoto N; Yamaguchi T; Nomura T; Ito H; Nakamura T; Sakaguchi N; Sakaguchi S

  J Exp Med. 2007 Nov 26;204(12):2803-12., 16 Jul. 2013, Peer-reviewed

  
• Plasticity of TH 17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses

  Keiji Hirota; Jan-Eric Turner; Matteo Villa; João H. Duarte; Jocelyne Demengeot; Oliver M. Steinmetz; Brigitta Stockinger

  Nature Immunology, Apr. 2013, Peer-reviewed

  
• Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3(+)CD25(+)CD4(+) regulatory T cells (vol 202, pg 885, 2005)

  Kuibeom Ko; Sayuri Yamazaki; Kyoko Nakamura; Tomohisa Nishioka; Keiji Hirota; Tomoyuki Yamaguchi; Jun Shimizu; Takashi Nomura; Tsutomu Chiba; Shimon Sakaguchi

  JOURNAL OF EXPERIMENTAL MEDICINE, Feb. 2012, Peer-reviewed

  
• Regulation and function of innate and adaptive interleukin-17-producing cells

  Keiji Hirota; Helena Ahlfors; Joao H. Duarte; Brigitta Stockinger

  EMBO REPORTS, Jan. 2012, Peer-reviewed

  
• An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

  Christoph Wilhelm; Keiji Hirota; Benjamin Stieglitz; Jacques Van Snick; Mauro Tolaini; Katharina Lahl; Tim Sparwasser; Helena Helmby; Brigitta Stockinger

  NATURE IMMUNOLOGY, Nov. 2011, Peer-reviewed

  
• External influences on the immune system via activation of the aryl hydrocarbon receptor

  Brigitta Stockinger; Keiji Hirota; Joao Duarte; Marc Veldhoen

  SEMINARS IN IMMUNOLOGY, Apr. 2011, Peer-reviewed

  
• Fate mapping of IL-17-producing T cells in inflammatory responses

  Keiji Hirota; Joao H. Duarte; Marc Veldhoen; Eve Hornsby; Ying Li; Daniel J. Cua; Helena Ahlfors; Christoph Wilhelm; Mauro Tolaini; Ursula Menzel; Anna Garefalaki; Alexandre J. Potocnik; Brigitta Stockinger

  NATURE IMMUNOLOGY, Mar. 2011, Peer-reviewed

  
• Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function

  Satoshi Tanaka; Shinji Maeda; Motomu Hashimoto; Chihiro Fujimori; Yoshinaga Ito; Shin Teradaira; Keiji Hirota; Hiroyuki Yoshitomi; Tomoya Katakai; Akira Shimizu; Takashi Nomura; Noriko Sakaguchi; Shimon Sakaguchi

  JOURNAL OF IMMUNOLOGY, Aug. 2010, Peer-reviewed

  
• Complement drives Th17 cell differentiation and triggers autoimmune arthritis

  Motomu Hashimoto; Keiji Hirota; Hiroyuki Yoshitomi; Shinji Maeda; Shin Teradaira; Shuji Akizuki; Paz Prieto-Martin; Takashi Nomura; Noriko Sakaguchi; Joerg Koehl; Birgitta Heyman; Minoru Takahashi; Teizo Fujita; Tsuneyo Mimori; Shimon Sakaguchi

  JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 2010, Peer-reviewed

  
• Development, regulation and functional capacities of Th17 cells

  Keiji Hirota; Bruno Martin; Marc Veldhoen

  SEMINARS IN IMMUNOPATHOLOGY, Mar. 2010, Peer-reviewed

  
• Interleukin-17-Producing gamma delta T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

  Bruno Martin; Keiji Hirota; Daniel J. Cua; Brigitta Stockinger; Marc Veldhoen

  IMMUNITY, Aug. 2009, Peer-reviewed

  
• Modulation of Th17 development and function by activation of the aryl hydrocarbon receptor - the role of endogenous ligands

  Brigitta Stockinger; Marc Veldhoen; Keiji Hirota

  EUROPEAN JOURNAL OF IMMUNOLOGY, Mar. 2009, Peer-reviewed

  
• Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

  Marc Veldhoen; Keiji Hirota; Jillian Christensen; Anne O'Garra; Brigitta Stockinger

  JOURNAL OF EXPERIMENTAL MEDICINE, Jan. 2009, Peer-reviewed

  
• Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis

  Chiaki Wakasa-Morimoto; Tomoko Toyosaki-Maeda; Takaji Matsutani; Ryu Yoshida; Shino Nakamura-Kikuoka; Miki Maeda-Tanimura; Hiroyuki Yoshitomi; Keiji Hirota; Motomu Hashimoto; Hideyuki Masaki; Yoshiki Fujii; Tsuneaki Sakata; Yuji Tsuruta; Ryuji Suzuki; Noriko Sakaguchi; Shimon Sakaguchi

  INTERNATIONAL IMMUNOLOGY, Oct. 2008, Peer-reviewed

  
• The aryl hydrocarbon receptor links T(H)17-cell-mediated autoimmunity to environmental toxins

  Marc Veldhoen; Keiji Hirota; Astrid M. Westendorf; Jan Buer; Laure Dumoutier; Jean-Christophe Renauld; Brigitta Stockinger

  NATURE, May 2008, Peer-reviewed

  
• Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.

  Keiji Hirota; Hiroyuki Yoshitomi; Motomu Hashimoto; Shinji Maeda; Shin Teradaira; Naoshi Sugimoto; Tomoyuki Yamaguchi; Takashi Nomura; Hiromu Ito; Takashi Nakamura; Noriko Sakaguchi; Shimon Sakaguchi

  The Journal of experimental medicine, 26 Nov. 2007, Peer-reviewed

  
• Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor

  Tomoyuki Yamaguchi; Keiji Hirota; Kanji Nagahama; Katsuya Ohkawa; Takeshi Takahashi; Takeshi Nomura; Shimon Sakaguchi

  IMMUNITY, Jul. 2007, Peer-reviewed

  
• T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17(+) Th cells that cause autoimmune arthritis

  Keiji Hirota; Motomu Hashimoto; Hiroyuki Yoshitomi; Satoshi Tanaka; Takashi Nomura; Tomoyuki Yamaguchi; Yoichiro Iwakura; Noriko Sakaguchi; Shimon Sakaguchi

  JOURNAL OF EXPERIMENTAL MEDICINE, Jan. 2007, Peer-reviewed

  
• Foxp3-dependent and -independent molecules specific for CD25(+)CD4(+) natural regulatory T cells revealed by DNA microarray analysis

  Naoshi Sugimoto; Takatoku Oida; Keiji Hirota; Kyoko Nakamura; Takashi Nomura; Takashi Uchiyama; Shimon Sakaguchi

  INTERNATIONAL IMMUNOLOGY, Aug. 2006, Peer-reviewed

  
• SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T cells.

  Sakaguchi S; Takahashi T; Hata H; Yoshitomi H; Tanaka S; Hirota K; Nomura T; Sakaguchi N

  In The hereditary Basis of Rheumatic Diseases, Progress in Inflammation Research. Edited by Rikard Holmdahl, Birkhaeuser Verlag, Basel, p147－159, 2006., 2006, Peer-reviewed

  
• Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3(+)CD25(+)CD4(+) regulatory T cells

  K Ko; S Yamazaki; K Nakamura; T Nishioka; K Hirota; T Yamaguchi; J Shimizu; T Nomura; T Chiba; S Sakaguchi

  JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 2005, Peer-reviewed

  
• A role for fungal beta-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

  H Yoshitomi; N Sakaguchi; K Kobayashi; GD Brown; T Tagami; T Sakihama; K Hirota; S Tanaka; T Nomura; Miki, I; S Gordon; S Akira; T Nakamura; S Sakaguchi

  JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 2005, Peer-reviewed

  
• Generation of autoaggresive CD4＋ T cells due to a ZAP-70 point mutation in SKG mice that spontaneous develop autoimmune arthritis.

  Keiji Hirota; Hiroyuki Yoshitomi; Satoshi Tanaka; Takashi Nomura; Noriko Sakaguchi; Shimon Sakaguchi

  Keystone Symposia Cellular Senescence and Cell Death（2005 3. 3－8. Colorado, USA）, 2005, Peer-reviewed

  
• Tumor Immunotherapy with anti GITR monoclonal antibody in mice.

  Keiji Hirota; Kwibeom Ko; Sayuri Yamazaki; Jun Shimizu; Kyoko Nakamura; Tomoyuki Yamaguchi; Takashi Nomura; Shimon Sakaguchi

  Keystone Symposia Regulatory/Suppressor T Cells（2004.3.10－15. Banff Canada）, 2004, Peer-reviewed

  

Misc.

• 腸管IL-23産生細胞の不均一性と機能制御機構

  廣田 圭司

  臨床免疫・アレルギー科, Jun. 2024

  
• 自己免疫疾患に関わるT細胞の制御因子

  小原 乃也; 廣田 圭司

  創薬研究者・アカデミア研究者が知っておくべき最新の免疫学とその応用技術, 31 Aug. 2021

  
• 臨床医が知っておくべき免疫学のいま：PathogenicヘルパーT細胞と組織炎症

  廣田 圭司

  別冊・医学のあゆみ, 25 Aug. 2021

  
• 炎症性Th17細胞による組織炎症の形成

  廣田 圭司

  炎症と免疫, 20 Aug. 2021

  
• PathogenicヘルパーT細胞と組織炎症

  廣田 圭司

  医学のあゆみ, Sep. 2020

  
• Th17細胞による関節炎惹起と慢性炎症の維持機構

  廣田 圭司

  リウマチ科、科学評論社, 28 Jun. 2020

  
• 自己免疫性関節炎の発症・慢性化の原因となる炎症ネットワークメカニズムの解明

  廣田 圭司

  医学のあゆみ、医歯薬出版株式会社, May 2019

  
• 新しい解析技術と今後のリウマチ学の発展 関節炎モデルSKGマウスを用いた免疫学的解析

  廣田 圭司

  日本リウマチ学会総会・学術集会プログラム・抄録集, Mar. 2019

  
• 【リンパ球研究の新展開】 自己免疫性関節炎を惹起するTh17細胞を起点とした炎症カスケード

  廣田 圭司

  臨床免疫・アレルギー科, Jan. 2019

  
• Th17細胞の転写制御機構の解明

  廣田 圭司

  上原記念生命科学財団研究報告集, 15 Dec. 2018

  
• マウス精子受精能とラフト局在変化の相関性

  渡邊仁美; 竹田理恵; 廣田圭司; 近藤玄

  日本実験動物学会総会講演要旨集, 27 Apr. 2018

  
• 慢性肝傷害・肝線維化における制御性T細胞の肝保護効果

  池野嘉信; 廣田圭司; 田浦康二朗; 祝迫惠子; 上本裕介; 吉野健史; 山本玄; 瀬尾智; 海道利実; 上本伸二

  肝臓, Apr. 2018

  
• マウス精子成熟における遺伝的背景の影響について

  渡邊仁美; 渡邊仁美; 竹田理恵; 竹田理恵; 廣田圭司; 廣田圭司; 近藤玄; 近藤玄

  日本IVF学会雑誌, 10 Sep. 2017

  
• 学会印象記(No.117)第45回 日本免疫学会学術集会

  廣田 圭司

  アレルギー・免疫, Jul. 2017

  
• 慢性炎症疾患の新たな展開 慢性炎症と疾患 自己免疫性関節炎を惹起するヘルパーTサブセットと認識自己抗原

  廣田圭司

  最新医学, 25 Nov. 2016

  
• マウス精子成熟における遺伝的背景の影響について

  渡邊仁美; 竹田理恵; 廣田圭司; 近藤玄

  日本IVF学会雑誌, 16 Sep. 2016

  
• Inflammatory circuit of Th17 cells, fibroblast-like synoviocytes, and ILCs in the development of autoimmune arthritis

  K. Hirota; Y. Ito; M. Hashimoto; H. Watanabe; G. Kondoh; A. Tanaka; K. Yasuda; M. Kopf; A. J. Potocnik; B. Stockinger; N. Sakaguchi; S. Sakaguchi

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016

  
• ゲノムオーガナイザーSatb1は制御性T細胞特異的なsuper-enhancerを構築し分化を成立させる

  北川 瑶子; 大倉 永也; 廣田 圭司; 安田 圭子; 近藤 元就; 谷内 一郎; Kohwi-Shigematsu Terumi; 坂口 志文

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• 関節リウマチの病態形成に関与するT細胞クローンの同定と新規自己抗原RPL23A

  廣田圭司; 橋本求; 坂口志文

  感染・炎症・免疫, 15 Oct. 2015

  
• 自然リンパ球の機能と腫瘍形成

  廣田 圭司

  がん免疫療法のメカニズム解明と臨床への展開；がんと免疫、南山堂, Oct. 2015

  
• 自己免疫と免疫寛容にかかわる免疫学の基本 2.Th17細胞の機能制御と自己免疫疾患

  廣田圭司

  実験医学, 01 Aug. 2015

  
• 腸管パイエル板におけるIgA産生に関与するT細胞

  廣田 圭司

  臨床免疫・アレルギー科, 25 Jun. 2014

  
• Th17と炎症:最新の知見 Th17細胞のPlasticity(可塑性)

  廣田圭司

  炎症と免疫, 20 Feb. 2013

  
• Plasticity of interleukin 17-producing T cells in inflammatory responses

  Keiji Hirota

  IMMUNOLOGY, Jun. 2012

  
• ヘルパーT細胞の分化とサイトカイン 6.ダイオキシン受容体によるTh17細胞の機能制御

  廣田圭司

  実験医学, 01 Aug. 2010

  
• Role of aryl hydrocarbon receptor in Th17 function

  廣田 圭司

  Clinical immunology & allergology, Mar. 2010

  
• 正常ZAP‐70の発現量操作による自己免疫性関節炎の誘導

  前田伸治; 田中聡; 廣田圭司; 藤森千尋; 野村尚史; 秋月修治; 橋本求; 伊藤能永; 坂口教子; 坂口志文

  日本免疫学会総会・学術集会記録, Nov. 2009

  
• 補体によるTh‐17依存性自己免疫性関節炎の制御

  橋本求; 廣田圭司; 吉富啓之; 前田伸治; 寺平晋; 秋月修二; PRIETO‐MARTIN Paz; 野村尚史; 坂口教子; 高橋実; 藤田禎三; 三森経世; 坂口志文

  日本免疫学会総会・学術集会記録, Nov. 2009

  
• 全身性自己免疫疾患 モデル解析 正常ZAP-70の発現量操作による自己免疫性関節炎の誘導

  前田 伸治; 田中 聡; 廣田 圭司; 藤森 千尋; 野村 尚史; 秋月 修治; 橋本 求; 伊藤 能永; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2009

  
• Rescue of autoimmune arthritis in SKG mice by normalization of TCR signaling transduction

  前田伸治; 田中聡; 廣田圭司; 橋本求; 寺平晋; 秋月修治; 野村尚史; 上田龍三; 坂口教子; 坂口志文

  日本免疫学会総会・学術集会記録, Nov. 2008

  
• SKGマウスの関節炎発症におけるdectin‐1依存的,非依存的な経路の解析

  橋本求; 廣田圭司; 吉冨啓之; 前田伸治; 寺平晋; 野村尚史; 坂口教子; 岩倉洋一郎; 三森経世; 坂口志文

  日本免疫学会総会・学術集会記録, Nov. 2008

  
• 関節リウマチ 動物モデル SKGマウスの関節炎発症におけるdectin-1依存的、非依存的な経路の解析

  橋本 求; 廣田 圭司; 吉冨 啓之; 前田 伸治; 寺平 晋; 野村 尚史; 坂口 教子; 岩倉 洋一郎; 三森 経世; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2008

  
• 全身性自己免疫疾患 モデル TCRシグナル伝達の補正によるSKGマウス自己免疫性関節炎の発症抑制(第2報)

  前田 伸治; 田中 聡; 廣田 圭司; 橋本 求; 寺平 晋; 秋月 修治; 野村 尚史; 上田 龍三; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2008

  
• SKG マウスの関節炎発症におけるdectine-1 依存的，非依存的な経路の解析/Dectin-1-dependant and - independent pathway for the induction of arthritis in SKG mice

  橋本求; 廣田圭司; 吉冨啓之; 前田伸治; 寺平晋; 野村尚史; 坂口教子; 岩倉洋一郎; 三森経世; 坂口志文

  第38回日本免疫学会学術集会（2008.12.1-3． 京都）, 2008, Peer-reviewed

  
• 「免疫難病・感染症等の先進医療技術」「制御性T細胞による新しい免疫制御法の開発」TCRシグナル伝達の補正によるSKGマウス自己免疫性関節炎の発症抑制

  前田伸治; 田中聡; 廣田圭司; 橋本求; 寺平晋; 秋月修治; 野村尚史; 上田龍三; 坂口教子; 坂口志文

  免疫難病・感染症等の先進医療技術 第5回(最終)公開シンポジウム要旨集 平成20年, 2008

  
• 免疫疾患と制御 4.Th17とSKG関節炎

  廣田圭司; 坂口志文

  Annual Review 免疫, 20 Nov. 2007

  
• 自己反応性T細胞のIL‐17産生と環境要因

  橋本求; 廣田圭司; 坂口志文

  月刊臨床免疫・アレルギー科, 25 Oct. 2007

  
• TCRシグナル伝達の補正によるSKGマウス自己免疫性関節炎の発症抑制

  前田伸治; 田中聡; 廣田圭司; 寺平晋; 橋本求; 野村尚史; 上田龍三; 坂口教子; 坂口志文

  日本免疫学会総会・学術集会記録, Oct. 2007

  
• SKGマウスにおける自己反応性CD4+T細胞集団の解析

  寺平晋; 廣田圭司; 橋本求; 前田伸治; 山口智之; 野村尚史; 坂口教子; 坂口志文

  日本免疫学会総会・学術集会記録, Oct. 2007

  
• TCRシグナル伝達の補正によるSKGマウス自己免疫性関節炎の発症抑制

  前田 伸治; 田中 聡; 廣田 圭司; 寺平 晋; 橋本 求; 野村 尚史; 上田 龍三; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Oct. 2007

  
• SKGマウスにおける自己反応性CD4+T細胞集団の解析

  寺平 晋; 廣田 圭司; 橋本 求; 前田 伸治; 山口 智之; 野村 尚史; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Oct. 2007

  
• Foxp3-expressing regulatory T cells in self-tolerance and autoimmune disease

  S. Sakaguchi; N. Sugimoto; M. Ono; T. Oida; K. Hirota; T. Yamaguchi; T. Nomura

  JOURNAL OF NEUROIMMUNOLOGY, Sep. 2006

  
• 新しいマーカーFolate receptor 4を発現する抗原特異的CD4+CD25+制御性T細胞による移植免疫寛容の誘導

  長濱寛二; 山口智之; 廣田圭司; 西村英士; 高橋武司; 小川修; 坂口志文

  移植, Sep. 2006

  
• リウマチと骨関節破壊 SKGマウス ZAP-70遺伝子変異による関節リウマチモデルマウス

  坂口 教子; 野村 尚史; 畑 洋; 吉富 啓之; 田中 聡; 廣田 圭司; 坂口 志文

  日本骨代謝学会学術集会プログラム抄録集, Jul. 2006

  
• SKGマウス:ZAP‐70遺伝子変異による関節リウマチモデルマウス

  坂口教子; 野村尚史; 畑洋; 吉富啓之; 田中聡; 廣田圭司; 坂口志文

  日本骨代謝学会学術集会プログラム抄録集, 2006

  
• 自己免疫性関節炎を自然発症するSKGマウスにおけるCD4+T細胞の自己反応性

  廣田 圭司; 吉富 啓之; 橋本 求; 田中 聡; 野村 尚史; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2005

  
• 関節炎を自然発症するSKGマウスにおける抗シトルリン化蛋白抗体産生の検討

  橋本 求; 吉冨 啓之; 田中 聡; 廣田 圭司; 野村 尚史; 坂口 教子; 三森 経世; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2005

  
• CD25+CD4+制御性T細胞によるSKGマウス関節炎の治療

  田中 聡; 橋本 求; 廣田 圭司; 吉富 啓之; 野村 尚史; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2005

  
• 関節炎を自然発症するSKGマウスにおける抗シトルリン化蛋白抗体産生の検討

  橋本 求; 吉冨 啓之; 田中 聡; 廣田 圭司; 野村 尚史; 坂口 教子; 三森 経世; 坂口 志文

  日本臨床免疫学会会誌, Aug. 2005

  
• CD25+CD4+制御性T細胞におけるFoxP3,CTLA-4の役割

  中村 恭子; 廣田 圭司; Fehervari Zoltan; 山口 智之; 野村 尚史; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• CD25+CD4+制御性T細胞に対するGITRLの役割と腫瘍免疫誘導

  西岡 朋尚; 廣田 圭司; 清水 淳; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• ZAP-70突然変異の結果自己免疫性関節炎を自然発症するSKGマウスの末梢CD4+T細胞動態

  廣田 圭司; 吉富 啓之; 野村 尚史; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• SKGマウスのZAP-70遺伝子突然変異による胸腺T細胞選択の偏倚と,その結果誘導される自己免疫疾患スペクトラムの変化

  田中 聡; 吉富 啓之; 廣田 圭司; 野村 尚史; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• CD25+CD4+制御性T細胞(Treg)の操作による腫瘍免疫の誘導

  高 貴範; 野村 尚史; 山崎 小百合; 清水 淳; 廣田 圭司; 中村 恭子; 千葉 勉; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• SKGマウスにおけるiNKT細胞機能解析

  廣田 圭司; Zoltan Fehervari; 吉富 啓之; 野村 尚史; 芹沢 功; 五十嵐 美徳; 若杉 尋; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2003

  

Presentations

• Heterogeneity and molecular basis of arthritogenic Th17 cells in inflamed joints

  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji; Hirota

  Keystone Symposia: T Cell Differentiation in Tissue Microenvironments, Vancouver, Canadda, 05 Feb. 2025

  
• IL-23 secretion by keratinocytes rather than antigen presenting cells play critical role in the pathogenesis of psoriasiform dermatitis

  Yoonha Lee; Daiya Ohara; Hiroki Mukoyama; Yusuke Takeuchi; Hitomi Watanabe, Gen; Kondoh; Keiji Hirota

  The 53rd Annual Meeting of the Japanese Society for Immunology, Nagasaki, Japan, 04 Dec. 2024

  
• Neutrophil-derived IL-23 p19 monomer suppresses type 17 immunity

  Daiya Ohara; Yusuke Takeuchi; Yoonha Lee; Hiroki Mukoyama; Hitomi Watanabe; Gen Kondoh; Keiji Hirota

  The 53rd Annual Meeting of the Japanese Society for Immunology, Nagasaki, Japan, 04 Dec. 2024

  
• Regnase-4 protects mice against HSV-1 infection by reinforcing type I interferon production

  Keiko Yasuda; Junichi Aoki; Kotaro Tanaka; Daiya Ohara; Keiji Hirota; Osamu Takeuchi

  The 53rd Annual Meeting of the Japanese Society for Immunology, Nagasaki, Japan, 04 Dec. 2024

  
• GM-CSF-dependent Macrophage Subpopulation Derived from Ly6Chi Monocytes Causes Development and Enhancement of Joint Inflammation in Autoimmune Arthritis

  Hiroki Mukoyama; Yusuke Takeuchi; Daiya Ohara; Yoonha Lee; Hitomi Watanabe, Gen; Kondoh; Akio Morinobu; Keiji Hirota

  The 53rd Annual Meeting of the Japanese Society for Immunology, Nagasaki, Japan, 04 Dec. 2024

  
• Expression of CD103 and CD200 define functionally distinct arthritogenic Th17 cells

  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji; Hirota

  The 53rd Annual Meeting of the Japanese Society for Immunology, Nagasaki, Japan, 04 Dec. 2024

  
• Keratinocytes rather than antigen presenting cells are critical source of IL-23 in psoriasiform dermatitis

  Yoonha Lee; Daiya Ohara; Hiroki Mukoyama; Yusuke Takeuchi; Hitomi Watanabe; Gen Kondoh; Keiji Hirota

  Cytokines 2024, 12th Annual Meeting of the International Cytokines & Interferon Society, Korea, 20 Oct. 2024

  
• Differentiation and activation of monocytes/macrophages induced by GM-CSF signaling exacerbates synovial inflammation in autoimmune arthritis

  Hiroki Mukoyama; Yusuke Takeuchi; Daiya Ohara; Yoonha Lee; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji Hirota

  Cytokines 2024, 12th Annual Meeting of the International Cytokines & Interferon Society, Korea, 20 Oct. 2024

  
• A three-stage differentiation pathway for highly arthritogenic CD103- CD200+ Th17 cells

  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji Hirota

  Cytokines 2024, 12th Annual Meeting of the International Cytokines & Interferon Society, Korea, 20 Oct. 2024

  
• Novel IL-23 reporter mice reveals the cellular and molecular regulation of IL-23 production in mucosal host defense

  Daiya Ohara; Yusuke Takeuchi; Hitomi Watanabe; Yoonha Lee; Hiroki Mukoyama; Toshiaki Ohteki; Gen Kondoh; Keiji Hirota

  Cytokines 2024, 12th Annual Meeting of the International Cytokines & Interferon Society, Korea, 20 Oct. 2024

  
• Multi-organ Inflammation Driven by Autoimmune Single TCR-bearing T Cells

  Keiji Hirota

  Immunology symposium at The Francis Crick Institute, London, UK, 11 Oct. 2024, Invited

  
• Dysregulation of Treg homeostasis by ADAR1 deficiency and chronic MDA5 signaling

  Domnica Luca; Sumin Lee; Keiji Hirota; Yasutaka Okabe; Junji Uehori; Kazushi Izawa; Anna; Lisa Lanz; Verena Schütte; Burcu Sivri; Yuta Tsukamoto; Fabian Hauck; Rayk Behrend; Axel Roers; Takashi Fujita; Ryuta Nishikomori; Min Ae Lee-Kirsch; Hiroki Kato

  The 7th TOLL Conference, Rotterdam, Netherlands, 18 Apr. 2024

  
• GM-CSF-induced differentiation and activation of CCR2+ monocytes in inflamed joints exacerbates synovial inflammation in autoimmune arthritis

  Hiroki Mukoyama; Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe, Gen; Kondoh; Akio Morinobu; Keiji Hirota

  The 52nd Annual Meeting of the Japanese Society for Immunology, Chiba, Japan, 18 Jan. 2024

  
• Sequential Notch2 and retinoic acid signals license IL-23 expression by EpCAM+ DCIR2+ CD103- cDC2 in gut-associated lymphoid tissues

  Daiya Ohara; Yusuke Takeuchi; Hitomi Watanabe; Yoonha Lee; Hiroki Mukoyama; Toshiaki Ohteki; Gen Kondoh; Keiji Hirota

  The 52nd Annual Meeting of the Japanese Society for Immunology, Chiba, Japan, 18 Jan. 2024

  
• Differential TCR affinities for self antigens between Treg and arthritogenic Th17 cells shape the functional imbalance that cause autoimmune arthritis

  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji Hirota

  The 52nd Annual Meeting of the Japanese Society for Immunology, Chiba, Japan, 18 Jan. 2024

  
• Sequential Notch2 and retinoic acid signals liceNotch2 and retinoic acid signals induce IL-23 expression by EpCAM+ DCIR2+ cDC2s in gut-associated lymphoid tissues

  Keiji Hirota

  The 52nd Annual Meeting of the Japanese Society for Immunology, Chiba, Japan, 18 Jan. 2024, Invited

  
• An IL-23 reporter strain reveals the developmental identity and functional regulations of the IL-23-producing gut cDC2s that mediate mucosal host defense against infectious pathogens

  Ohara D; Takeuchi Y; Watanabe H; Lee Y; Mukoyama H; Ohteki T; Kondoh G; Hirota K

  11th Annual Meeting of the International Cytokine & Interferon Society, Athen, Greece, 18 Oct. 2023

  
• Regulation and cell fate of CCR2 + inflammatory monocytes in the development of T cell-dependent autoimmune arthritis

  Hiroki Mukoyama; Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji Hirota

  第51回 日本免疫学会学術集会, Dec. 2022

  
• Differential TCR repertoire for joint self-antigens determines the functional balance between the regulatory T and arthritogenic T cells in T cell-mediated autoimmune arthritis

  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Gen Kondoh; Akio Morinobu; Keiji Hirota

  第51回 日本免疫学会学術集会, Dec. 2022

  
• An Il23a-Venus reporter strain reveals the spatio-temporal regulation of IL-23- producing cDC2 subset in gut-associated lymphoid tissues

  Daiya Ohara; Hitomi Watanabe; Yusuke Takeuchi; Yoonha LEE; Mukoyama Hiroki; Gen Kondoh; Keiji Hirota

  第51回 日本免疫学会学術集会, Dec. 2022

  
• Contribution of T cell receptor- and Interleukin-2- signaling to the coordination of Treg-associated enhancer landscape

  Ryoji Kawakami; Yohko Kitagawa; Kelvin Y. Chen; Masaya Arai; Daiya Ohara; Yamami Nakamura; Keiko Yasuda; Motonao Osaki; Norihisa Mikami; Caleb A. Lareau; Hitomi; Watanabe; Gen Kondoh; Keiji Hirota; Naganari Ohkura; Shimon Sakaguchi

  第50回 日本免疫学会学術集会, Dec. 2021

  
• Foxp3+ regulatory T cells suppress chronic inflammation and fibrosis in the liver by regulating tissue cellular immunity in CCl4-induced liver injury

  Ohara D; Takeuchi Y; Watanabe H; Kondoh G; Hirota K

  第50回 日本免疫学会学術集会, Dec. 2021

  
• 自己免疫性関節炎の滑膜組織炎症における炎症性細胞サブセットの役割

  廣田 圭司

  第38回日本骨代謝学会学術集会, Oct. 2020, Invited

  
• Gsdmd and Ripk3 are dispensable for the induction and chronic inflammation of SKG arthritis

  Takeuchi Y, Watanabe H, Kondoh G, Sakaguchi N, Sakaguchi S, Hirota K

  第48回 日本免疫学会学術集会, 13 Dec. 2019

  
• A crucial role of the conserved non-coding sequences Foxp3-CNS0 and -CNS3 in the lineage specification of thymic Foxp3+ regulatory T cells

  Kawakami R, Kitagawa Y, Yasuda K, Mikami N, Ohkura N, Watanabe H, Chen K, Kondoh G, Hirota K, Sakaguchi S

  第48回 日本免疫学会学術集会, 12 Dec. 2019

  
• Satb1 controls GM-CSF and PD-1 expression by pathogenic Th17 cells

  Hirota K, Yasuda K, Kitagawa Y, Kawakami R, Watanabe H, Kondoh G, Sakaguchi S

  7th Annual Meeting of the International Cytokine & Interferon Society, Oct20-23, 2019, Vienna, Austria, 21 Oct. 2019

  
• 胸腺Treg分化におけるFoxp3-CNS0/CNS3領域の重要性

  川上竜司、北川瑶子、Chen K、安田圭子、大倉永也、渡邊仁美、近藤玄、廣田圭司、坂口志文

  Kyoto T Cell Conference 第29回学術集会, 09 Jun. 2019

  
• 胸腺における負の選択に特化した機能を持つゲノミックエンハンサーの同定と機能解析

  北條未来、増田喬子、北条広朗、長畑洋佑、安田圭子、小原及也、竹内悠介、廣田圭司、鈴木穣、河本宏、河岡慎平

  Kyoto T Cell Conference 第29回学術集会, 08 Jun. 2019

  
• 関節炎モデルSKGマウスを用いた免疫学的解析

  廣田 圭司

  第63回 日本リウマチ学会学術集会, 16 Apr. 2019, Invited

  
• 関節炎惹起性T細胞の分化と慢性炎症維持機構

  廣田 圭司

  「感染・免疫・がん・炎症」シンポジウム, 27 Mar. 2019, Invited

  
• Inflammatory cascade of autoimmune arthritis by Th17 cells and GM-CSF-producing ILCs

  廣田 圭司

  Keystone symposia, 20 Feb. 2019

  
• The Genome Organizer Satb1 Regulates GM-CSF and PD-1 Expression in Encephalitogenic Th17 Cells

  Yasuda K, Kitagawa Y, Kawakami R, Isaka Y, Watanabe H, Kondoh G, Kohwi-Shigematsu T, Sakaguchi S, Hirota K

  The 8th NIF Winter School on Advanced Immunology, Singapore, 21 Jan. 2019

  
• 炎症組織の細胞社会学

  廣田 圭司

  第3回 個体の中の細胞社会学ワークショップ, 11 Jan. 2019, Invited

  
• A role of Ripk3 and Gsdmd in the development of autoimmune arthritis in SKG mice

  Takeuchi Y; Watanabe H; Kondoh G; Sakaguchi N; Sakaguchi S; Mimori T; Hirota K

  第47回 日本免疫学会学術集会, 10 Dec. 2018

  
• Satb1-mediated regulation of GM-CSF and PD-1 in effector Th17 cells in experimental autoimmune encephalomyelitis

  Yasuda K; Kitagawa Y; Kawakami R; Watanabe H; Kondoh G; Kohwi-Shigematsu T; Sakaguchi S; Hirota K

  第47回 日本免疫学会学術集会, 10 Dec. 2018

  
• Autoimmune Th17 cells instruct ILC secretion of inflammatory GM-CSF to initiate and augment autoimmune arthritis

  廣田 圭司

  第47回 日本免疫学会学術集会, 10 Dec. 2018, Invited

  
• GM-CSF-producing synovial ILCs exacerbate Th17-mediated autoimmune arthritis

  Hirota K; Hashimoto M; Ito Y; Matsuura M; Ito H; Tanaka M; Watanabe H; Kondoh G; Tanaka A; Yasuda K; Kopf M; Potocnik AJ; Stockinger B; Sakaguchi N; Sakaguchi S

  The 3rd International Conference on Innate Lymphoid Cells, 29 Nov. 2018

  
• Epigenetic landscape of FOXP3 enhancer sites during thymic FOXP3+ TREG development of CNS0- and cNS3-deficient mice

  Kawakami R; Kitagawa Y; Hirota K; Watanabe H; Kondoh G; Ohkura N; Sakaguchi S

  6th Annual Meeting of the International Cytokine & Interferon Society, 27 Oct. 2018

  
• Satb1-mediated regulation of GM-CSF and PD-1 in pathogenic Th17 cells

  Yasuda K; Kitagawa Y; Kawakami R; Isaka Y; Watanabe H; Kondoh G; Kohwi-Shigematsu T; Sakaguchi S; Hirota K

  6th Annual Meeting of the International Cytokine & Interferon Society, 27 Oct. 2018

  
• Autoimmune arthritis mediated by inflammatory Th17 cells

  廣田 圭司

  25th East Asia Joint Symposium, 25 Oct. 2018, Invited

  
• An inflammatory cellular cascade of autoimmune Th17 cells, GM-CSF-producing synovial ILCs and stromal cells in the development of autoimmune arthritis

  廣田 圭司

  Kyoto T cell Conference, 15 Jun. 2018

  
• Characterization of Innate lymphoid cells in in¬amed gingiva of mice infected with Porphyromonas gingivalis

  Ryoki Kobayashi; Yohei Watanabe; Noriko M Tsuji; Keiji Hirota; Tomoko Kurita-Ochiai

  第46回 日本免疫学会学術集会, 12 Dec. 2017

  
• Lipid raft dynamics linked to sperm competency for fertilization in mice

  Gen Kondoh; Hitomi Watanabe; Rie Takeda; Keiji Hirota

  第4回国際生殖生物学会, 27 Sep. 2017

  
• An inflammatory cellular network of autoimmune Th17 cells, GM-CSF-producing ILCs and synoviocytes in the development of autoimmune arthritis

  廣田 圭司

  Keystone symposia, Immune Regulation in Autoimmunity and Cancer, 26 Mar. 2017, Invited

  
• Th17 cells orchestrate an inflammatory circuit in the development of autoimmune arthritis

  廣田 圭司

  World Immune Regulation Meeting X, 16 Mar. 2016, Invited

  
• Generation of highly self-reactive T helper cells in SKG autoimmune arthritis

  廣田 圭司

  第１０回 研究所ネットワーク国際シンポジウム, 23 Jul. 2015, Invited

  
• T cell-dependent IgA responses by plastic Th17 cells

  廣田 圭司

  IMMUNOLOGY 2014, The American Association of Immunologists Annual Meeeting, 02 May 2014, Invited

  
• Function and regulation of autoimmune T helper cells

  廣田 圭司

  The 3rd CSI/JSI/KAI Joint Symposium on Immunology, 01 Dec. 2013, Invited

  
• Th17 plasticity in homeostasis and inflammation

  廣田 圭司

  Joint Internatioal Symposium: JSICR-MMCB, 20 May 2013, Invited

  
• Plasticity of interleukin 17-producing T cells in inflammatory responses

  廣田 圭司

  Regulatory T cell and T helper cells: Fundamental Biology and Translation Research, Mar. 2012, Invited

  
• Plasticity of interleukin 17-producing T cells in inflammatory responses

  廣田 圭司

  第40回日本免疫学会学術集会, Nov. 2011, Invited

  
• Fate mapping of Interleukin-17 producing T cells in inflammatory responses

  廣田 圭司

  European Thymus Workshop, May 2011, Invited

  
• Contribution of IL-6 to spontaneous differentiation into IL-17-producing arthritogenic T cells in SKG mice

  廣田 圭司

  EULAR Congress 2007, Jun. 2007, Invited

  
• ＳＫＧマウスの関節炎惹起性IL-17産生T細胞の分化におけるIL-6の役割

  廣田 圭司

  第51回日本リウマチ学会総会, Apr. 2007, Invited

  

Industrial Property Rights

• 特許第4730733号, 特開2006-304740, 特願2005-134279, 4型葉酸受容体の発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤

  坂口 志文; 廣田 圭司; 山口 智之

  
• 特開2006-304740, 特願2005-134279, 4型葉酸受容体の発現を指標とした制御性T細胞の検出方法、及び免疫賦活剤

  坂口 志文; 廣田 圭司; 山口 智之

  

Awards

• 15 Apr. 2015

  文部科学省, 文部科学大臣表彰 若手科学者賞
• 08 Jul. 2014

  大阪大学, 大阪大学総長奨励賞
• 12 Dec. 2013

  日本免疫学会, 日本免疫学会　第8回研究奨励賞

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Immunology I

  8014, Fall, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From Apr. 2017, To Mar. 2018

  ILAS Seminar

  Spring, 全学共通科目

Administration

Faculty management (title, position)

• From 01 Apr. 2023

  共同利用機器等委員会　委員
• From 01 Oct. 2016

  自己点検・評価委員会　委員
• From 01 Apr. 2021

  兼業・利益相反審査委員会　委員
• From 06 May 2021

  予算委員会　委員

Academic, Social Contribution

Committee Memberships

• From Jan. 2017, To Dec. 2030

  評議員, 日本免疫学会