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Hattori, Ayuna

Institute for Life and Medical Sciences (LiMe) Associate Professor

Hattori, Ayuna
list
    Last Updated :2025/05/27

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Pharmaceutical Sciences, 薬科学専攻 がん・幹細胞シグナル学, 准教授
    • Graduate School of Medicine, 医学専攻 がん・幹細胞シグナル, 准教授
    • Graduate School of Medicine, 医科学専攻がん・幹細胞シグナル, 准教授

    Academic Degree

    • 修士(理学)(名古屋大学)
    • 博士(理学)(名古屋大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/27

      Research

      Research Areas

      • Life sciences, Molecular biology

      Papers

      • 分岐鎖アミノ酸代謝を介した正常組織幹細胞とがん幹細胞維持機構
        服部鮎奈; 慶澤遥; 伊藤貴浩
        生体の科学, Oct. 2023, Invited, Lead author
      • The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation.
        Ruochong Wang; Futaba Kato; Rio Yasui Watson; Aaron M Beedle; Jarrod A Call; Yugo Tsunoda; Takeshi Noda; Takaho Tsuchiya; Makoto Kashima; Ayuna Hattori; Takahiro Ito
        Life science alliance, May 2024, Peer-reviewed
      • Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia
        Ayuna Hattori; Emi Takamatsu-Ichihara; Yoshiki Yamamoto; Shuhei Fujita; Kazutsune Yamagata; Takuo Katsumoto; Yukino Machida; Haruka Shinohara; Ryo Murakami; Issay Kitabayashi
        Leukemia, 25 Jul. 2023, Peer-reviewed, Lead author, Corresponding author
      • Dual targeting of EZH1 and EZH2 for the treatment of malignant rhabdoid tumors.
        Haruka Shinohara; Rie Sawado; Makoto Nakagawa; Ayuna Hattori; Kazutsune Yamagata; Kimiharu Tauchi; Jumpei Ito; Yasumichi Kuwahara; Tsukasa Okuda; Chitose Ogawa; Issay Kitabayashi
        Molecular therapy oncolytics, 15 Dec. 2022, Peer-reviewed
      • Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia.
        Koji Jimbo; Ayuna Hattori; Shuhei Koide; Takahiro Ito; Katsuhiro Sasaki; Kazuhiro Iwai; Yasuhito Nannya; Atsushi Iwama; Arinobu Tojo; Takaaki Konuma
        Leukemia, 09 Nov. 2022, Peer-reviewed
      • Clinical usefulness of 2-hydroxyglutarate as a biomarker in IDH-mutant chondrosarcoma
        Makoto Nakagawa; Masayuki Yamaguchi; Makoto Endo; Yukino Machida; Ayuna Hattori; Fumie Tanzawa; Shinji Tsutsumi; Issay Kitabayashi; Akira Kawai; Fumihiko Nakatani
        Journal of Bone Oncology, Jun. 2022, Peer-reviewed
      • 代謝からみえる幹細胞の機能制御と造血器腫瘍
        山本佳輝; 服部鮎奈; 伊藤貴浩
        血液内科, May 2022
      • Determination of intracellular 2-hydroxyglutarate enantiomers using two-dimensional liquid chromatography
        Takuma Ohtawa; Ayuna Hattori; Muneki Isokawa; Masashi Harada; Takashi Funatsu; Takahiro Ito; Makoto Tsunoda
        Journal of Chromatography Open, Nov. 2021, Peer-reviewed
      • がん組織における分岐鎖アミノ酸代謝制御
        服部 鮎奈
        May 2020, Lead author
      • Amino acid metabolism for cancer therapy.
        服部 鮎奈
        Apr. 2020, Lead author
      • BCAA代謝のリプログラミングによるがん幹細胞維持の機構
        服部 鮎奈; 伊藤 貴浩
        Jun. 2018, Lead author
      • Analysis of intracellular alpha-keto acids by HPLC with fluorescence detection
        Takuya Fujiwara; Ayuna Hattori; Takahiro Ito; Takashi Funatsu; Makoto Tsunoda
        ANALYTICAL METHODS, May 2020, Peer-reviewed
      • A Potent Blood–Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model
        Yukino Machida; Makoto Nakagawa; Hironori Matsunaga; Masayuki Yamaguchi; Yoko Ogawara; Yutaka Shima; Kazutsune Yamagata; Takuo Katsumoto; Ayuna Hattori; Masato Itoh; Takahiko Seki; Yumi Nishiya; Koichi Nakamura; Kanae Suzuki; Tomoki Imaoka; Daichi Baba; Makoto Suzuki; Oltea Sampetrean; Hideyuki Saya; Koichi Ichimura; Issay Kitabayashi
        Molecular Cancer Therapeutics, Feb. 2020, Peer-reviewed
      • Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma.
        Makoto Nakagawa; Fumihiko Nakatani; Hironori Matsunaga; Takahiko Seki; Makoto Endo; Yoko Ogawara; Yukino Machida; Takuo Katsumoto; Kazutsune Yamagata; Ayuna Hattori; Shuhei Fujita; Yukiko Aikawa; Takamasa Ishikawa; Tomoyoshi Soga; Akira Kawai; Hirokazu Chuman; Nobuhiko Yokoyama; Suguru Fukushima; Kenichiro Yahiro; Atsushi Kimura; Eijiro Shimada; Takeshi Hirose; Toshifumi Fujiwara; Nokitaka Setsu; Yoshihiro Matsumoto; Yukihide Iwamoto; Yasuharu Nakashima; Issay Kitabayashi
        Oncogene, Oct. 2019, Peer-reviewed
      • Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma.
        Nakagawa M; Fujita S; Katsumoto T; Yamagata K; Ogawara Y; Hattori A; Kagiyama Y; Honma D; Araki K; Inoue T; Kato A; Inaki K; Wada C; Ono Y; Yamamoto M; Miura O; Nakashima Y; Kitabayashi I
        Cancer science, Jan. 2019, Peer-reviewed
      • Continuous in vivo Metabolism by NMR.
        Judge MT; Wu Y; Tayyari F; Hattori A; Glushka J; Ito T; Arnold J; Edison AS
        Frontiers in molecular biosciences, 2019, Peer-reviewed
      • Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
        Ayuna Hattori; Makoto Tsunoda; Takaaki Konuma; Masayuki Kobayashi; Tamas Nagy; John Glushka; Fariba Tayyari; Daniel M. Cskimming; Natarajan Kannan; Arinobu Tojo; Arthur S. Edison; Takahiro Ito
        NATURE, May 2017, Peer-reviewed, Lead author
      • RNA binding protein MSI2 positively regulates FLT3 expression in myeloid leukemia
        Ayuna Hattori; Daniel McSkimming; Natarajan Kannan; Takahiro Ito
        LEUKEMIA RESEARCH, Mar. 2017, Peer-reviewed, Lead author
      • Analysis of Branched-Chain Keto Acids in Cell Extracts by HPLC-Fluorescence Detection
        Ayuna Hattori; Takahiro Ito; Makoto Tsunoda
        CHROMATOGRAPHY, 2017, Peer-reviewed, Lead author
      • Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi
        Takashi Fukuzono; Strahil Iv. Pastuhov; Okinobu Fukushima; Chun Li; Ayuna Hattori; Shun-ichiro Iemura; Tohru Natsume; Hiroshi Shibuya; Hiroshi Hanafusa; Kunihiro Matsumoto; Naoki Hisamoto
        GENES TO CELLS, Apr. 2016, Peer-reviewed

      External funds: Kakenhi

      • タンパク質切断による新しい幹細胞機能制御の解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 54010:Hematology and medical oncology-related
        Kyoto University
        服部 鮎奈
        From 01 Apr. 2022, To 31 Mar. 2026, Granted
        がん幹細胞;RNA結合因子
      • Regulation of cancer stem cell by RNA binding protein
        Grant-in-Aid for Early-Career Scientists
        Basic Section 54010:Hematology and medical oncology-related
        Kyoto University;National Cancer Center Japan
        Ayuna Hattori
        From 01 Apr. 2020, To 31 Mar. 2023, Discontinued
        がん幹細胞;細胞運命決定;白血病;転写後制御
      • The possibility of cancer therapy targeting to cellular iron metabolism
        Grant-in-Aid for Scientific Research (C)
        Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
        Tokai University
        Masaki Miyazawa
        From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
        がん;鉄代謝;抗がん剤;シスプラチン;IRP2
      • Understanding metabolic impacts by IDH mutations and validating the efficacy of therapeutic targeting of BCAT1
        Grant-in-Aid for Research Activity Start-up
        0904:Internal medicine of the bio-information integration and related fields
        National Cancer Center Japan
        Ayuna Hattori
        From 24 Aug. 2018, To 31 Mar. 2020, Project Closed
        がん代謝;白血病;アミノ酸;IDH
      • 鉄代謝因子阻害薬による革新的がん治療法の開発
        Grant-in-Aid for Scientific Research (C)
        Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
        Tokai University
        宮沢 正樹
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        鉄代謝;がん;IRP;IRE;創薬
      • タンパク質切断による新しい幹細胞機能制御の解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 54010:Hematology and medical oncology-related
        Kyoto University
        服部 鮎奈
        From 01 Apr. 2022, To 31 Mar. 2026, Granted
        がん幹細胞;RNA結合因子
      • 腸内糖鎖資化性細菌由来低分子代謝物による他臓器、腫瘍幹細胞の機能制御解明
        Grant-in-Aid for Transformative Research Areas (B)
        Transformative Research Areas, Section (III)
        Kyoto University
        服部 鮎奈
        From 01 Apr. 2025, To 31 Mar. 2028, Adopted

      External funds: others

      • アミノ酸代謝制御を介した慢性炎症による発がん機構の解明 (2023年度分)
        国立研究開発法人日本医療研究開発機構, 研究者育成支援研究奨励事業助成金
        From 01 Apr. 2023, To 31 Mar. 2024
        代表
      list
        Last Updated :2025/05/27

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          Research Proposal Writing Practice B
          8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Research Proposal Writing Practice A
          8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Pharmaceutical Laboratory Coaching Practice A
          8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Medicinal Frontier Science Research B
          8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2024, To 31 Mar. 2025
          Medicinal Frontier Science Research A
          8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2024, To 31 Mar. 2025
          Pharmaceutical Laboratory IV : Biochemistry and Microbiology
          C906, Fall, Faculty of Pharmaceutical Sciences, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          Medicinal Frontier Science Research C
          8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2024, To 31 Mar. 2025
          Seminar on Critical Reading of Scientific Papers B
          8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Seminar on Critical Reading of Scientific Papers A
          8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Research Proposal Writing Practice A
          8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Pharmaceutical Laboratory Coaching Practice A
          8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Research Proposal Writing Practice B
          8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Pharmaceutical Laboratory IV : Biochemistry and Microbiology
          C906, Fall, Faculty of Pharmaceutical Sciences, 3
        • From 01 Apr. 2023, To 31 Mar. 2024
          Medicinal Frontier Science Research B
          8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2023, To 31 Mar. 2024
          Medicinal Frontier Science Research A
          8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2023, To 31 Mar. 2024
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          A906, Fall, Faculty of Pharmaceutical Sciences, 4
        • From 01 Apr. 2023, To 31 Mar. 2024
          Seminar on Critical Reading of Scientific Papers B
          8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Seminar on Critical Reading of Scientific Papers A
          8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Medical Frontier Science Research A
          8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          ILAS Seminar
          Z001, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutical Laboratory 4 : Biochemistry and Microbiology
          A906, Fall, Faculty of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar on Critical Reading of Scientific Papers A
          8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutical Laboratory IV : Biochemistry and Microbiology
          C906, Fall, Faculty of Pharmaceutical Sciences, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutical Laboratory Coaching Practice A
          8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research Proposal Writing Practice A
          8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
        list
          Last Updated :2025/05/27

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2024
            共同利用機器等委員会 委員
          • From 01 Apr. 2023
            男女共同参画推進委員会 委員

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