Hirano, Sayuki(Graduate School of Biostudies, Division of Integrated Life Science) | Activity Database on Education and Research, Kyoto University

Hirano, Sayuki

Graduate School of Biostudies, Division of Integrated Life Science Assistant Professor

Last Updated :2026/05/11

Basic Information

Faculty

Faculty of Science

Email Address

Email Address
hirano.sayuki.2kkyoto-u.ac.jp

Professional Memberships

From Apr. 2023, To Present
Japan Society for Cell Biology

From Jul. 2020, To Present
Japanese Society of Developmental Biologists

From Oct. 2018, To Present
The Molecular Biology Society of Japan

From May 2017, To Feb. 2023
The Zoological Society of Japan

Academic Degree

25 Mar. 2019
東京大学修士（学術）

24 Mar. 2022
東京大学博士（学術）

Academic Resume (Undergraduate School/Majors)

東京大学, 教養学部統合自然科学科, 卒業

Research History

From Mar. 2025, To Present
Kyoto University, Graduate School of Biostudies, Assistant Professor

From Apr. 2024, To Feb. 2025
Kyoto University, Graduate School of Biostudies, Program-Specific Researcher (JSPS-PD)

From Apr. 2023, To Mar. 2024
National Institutes of Natural Sciences, Exploratory Research Center on Life and Living Systems (ExCELLS), JSPS Postdoctoral Fellow

From Apr. 2022, To Mar. 2023
National Institute for Basic Biology, Spectrography and Bioimaging Facility, Project Research Stuff

From Apr. 2019, To Mar. 2022
Japan Society for the Promotion of Science, Research Fellow (DC1)

From Jan. 2020, To Sep. 2020
Japan Society for the Promotion of Science, JSPS-ERC Research Fellow

ID,URL

ORCID ID
0000-0001-7183-6604
J-Global ID
202101013956027371
Researcher number
50973046

researchmap URL

https://researchmap.jp/hirano-sayuki

Last Updated :2026/05/11

Research

Research Interests

Cell adhesion

cell migration

mechanical signal

planar cell polarity

Xenopus laevis

morphogenesis

Research Areas

Life sciences, Biophysics

Life sciences, Developmental biology

Life sciences, Cell biology

Papers

ZO-1 shuttles between apical junctional complexes and podosomes by riding ERK activation waves
Sayuki Hirano; Yohei Kondo; Asayuki Kitajima; Noriyuki Kinoshita; Tetsuhisa Otani; Mikio Furuse; Naoto Ueno; Kazuhiro Aoki
Nature Communications, 09 May 2026, Peer-reviewed, Lead author, Corresponding author

Wnt signaling and tissue tension reconstitute planar cell polarity in vitro
Soichi Matsuo; Minako Suzuki; Sayuki Hirano; Tetsuhisa Otani; Yusuke Mii
bioRxiv, 05 May 2026

Localized heat induces ERK activation and signal propagation in solid tumors
Farsai Taemaitree; Yuta Takano; Daisuke Yamaguchi; Kazushi Yamaguchi; Yudai Yamashita; Motosuke Tsutsumi; Chentao Wen; Kohei Otomo; Kenji Hirai; James Hutchison; Indra Zunder; Sandra Krzyzowska; Maria Bravo; Sayuki Hirano; Koutarou D. Kimura; Kazuhiro Aoki; Susana Rocha; Tomomi Nemoto; Beatrice Fortuni; Hiroshi Uji-i
Scientific Reports, 30 Apr. 2026, Peer-reviewed

Dynamic behavior of cell-cell adhesion factors in collective cell migration.
Sayuki Hirano; Kazuhiro Aoki; Naoto Ueno
Cells & development, 23 Jan. 2025, Peer-reviewed, Invited, Lead author, Corresponding author
Access this paper :

Alignment of the cell long axis by unidirectional tension acts cooperatively with Wnt signalling to establish planar cell polarity
Sayuki Hirano; Yusuke Mii; Guillaume Charras; Tatsuo Michiue
Development, 15 Jun. 2022, Peer-reviewed, Lead author

FRET-based tension measurement across actin-associated mechanotransductive structures using Lima1
Sayuki Hirano; Takayoshi Yamamoto; Tatsuo Michiue
The International Journal of Developmental Biology, 10 Oct. 2018, Peer-reviewed, Lead author

Fam46a regulates BMP-dependent pre-placodal ectoderm differentiation in Xenopus
Tomoko Watanabe; Takayoshi Yamamoto; Kohei Tsukano; Sayuki Hirano; Ayumi Horikawa; Tatsuo Michiue
Development, 01 Jan. 2018, Peer-reviewed

Presentations

Dynamic redistribution of adhesion-related molecules tunes collective cell behavior
Sayuki Hirano
International Symposium - Physical Biology of Multicellular Dynamics, 12 Mar. 2026, Invited

Spatiotemporal dynamics of ZO-1 localization in epithelial cell collectives
Sayuki Hirano
Singapore–Japan Mini-workshop on Coordination and Competition in Multicellular Systems, 20 Nov. 2025, Invited

ERK-dependent translocation of ZO-1 regulates epithelial cell invasion
Sayuki Hirano; Yohei Kondo; Naoto Ueno; Kazuhiro Aoki
The 84th Annual Meeting of the Japanese Cancer Association, 25 Sep. 2025, Invited

ERK-Driven Relocation of ZO-1 to Podosomes during Collective Cell Migration
Sayuki Hirano; Yohei Kondo; Naoto Ueno; Kazuhiro Aoki
Winter Q-Bio Conference 2025, 19 Feb. 2025

ZO-1 shuttles between tight junctions and podosomes riding on ERK activation waves and facilitates cell invasion
Sayuki Hirano; Yohei Kondo; Naoto Ueno; Kazuhiro Aoki
The 47th Annual Meeting of the Molecular Biology Society of Japan, 28 Nov. 2024

Apical-to-basal translocation of ZO-1 and its contribution to cell invasion
Sayuki Hirano; Yohei Kondo; Naoto Ueno; Kazuhiro Aoki
The 97th Annual Meeting of the Japanese Biochemical Society, 07 Nov. 2024, Invited

ERK-driven translocation of ZO1 to cell-ECM adhesion structure exerts traction force for promoting collective cell migration and invasion
Sayuki hirano; Yohei kondo; Naoto ueno; Kazuhiro aoki
The 52nd Naito Conference, Frontiers of Physical and Mechanical Biology, 03 Oct. 2024

ERK-mediated ZO1 transition to cell-ECM adhesion structure exerts traction force to promote cell migration and invasion
Sayuki Hirano; Yohei Kondo; Naoto Ueno; Kazuhiro Aoki
The 76th Annual Meeting of the Japan Society for Cell Biology, 17 Jul. 2024

Subcellular Shuttling of ZO-1 Coordinates Collective Cell Migration
Sayuki Hirano; Kazuhiro Aoki; Naoto Ueno
The 61st Annual Meeting of the Biophysical Society of Japan, 14 Nov. 2023, Invited

Unidirectional tension acts cooperatively with Wnt to establish PCP
Sayuki Hirano; Yusuke Mii; Guillaume Charras; Tatsuo Michiue
The 56th annual meeting of the Japanese Society of the developmental biologists, 23 Jul. 2023, Invited

Regulation of Collectice Cell Migration by ZO-1 Dynamics
Sayuki Hirano; Kazuhiro Aoki; Naoto Ueno
The 75th Annual Meeting of the Japan Society for Cell Biology, 28 Jun. 2023

Subcellular Shuttling of ZO-1 Facilitates Collective Cell Migration
Sayuki Hirano; Kazuhiro Aoki; Naoto Ueno
Tight Junction Symposium 2023, 05 Jun. 2023

Dynamics of phase-separated ZO-1 condensates and their effects on cell migration
Sayuki Hirano
The 3rd NINS-Princeton Joint Symposium, 22 Mar. 2023

Regulation of Cell Migration via Liquid-Liquid Phase Separation of ZO-1
Sayuki Hirano; Noriyuki Kinoshita; Kazuhiro Aoki; Naoto Ueno
The 45th Annual Meeting of the Molecular Biology Society of Japan, 01 Dec. 2022

Regulation of Planar Cell Polarity by Unidirectional Tissue Stretch
Sayuki Hirano; Guillaume Charras; Tatsuo Michiue
The 43th Annual Meeting of the Molecular Biology Society of Japan, Dec. 2020

Regulation of Planar Cell Polarity by Mechanical Stimulus
Sayuki Hirano; Tatsuo Michiue
The 42th Annual Meeting of the Molecular Biology Society of Japan, Dec. 2019

Development of FRET-based Tension Sensor Using Actin-Binding Protein Lima1
Sayuki Hirano; Takayoshi Yamamoto; Tatsuo Michiue
The 41th Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018

Observation of Tension on Xenopus Neural Plate using FRET-based Tension Sensor
Sayuki Hirano; Tatsuo Michiue
The 89th Annual Meeting of the Zoological Society of Japan, Sep. 2018

Analysis of Mechanical Stimuli on Xenopus Neural Plate during Establishment of Planar Cell Polarity
Sayuki Hirano; Tatsuo Michiue
The 12th Japan Xenopus Conference, Sep. 2018

Development of Cell Tension Sensor using FRET
Sayuki Hirano; Tatsuo Michiue
The 11th Japan Xenopus Conference, Sep. 2017

Development of FRET-based Tension Sensor LimaTS and Observation of Tissue Tension in Xenopus Embryo
Sayuki Hirano; Tatsuo Michiue
The 88th Annual Meeting of the Zoological Society of Japan, Sep. 2017

Development of Cell Tension Sensor using FRET module
Sayuki Hirano; Tatsuo Michiue
The 69th Kanto-Area Meeting of the Zoological Society of Japan, Mar. 2017

External funds: Kakenhi

癌細胞排除時の細胞間接着リモデリング機構の解析
Grant-in-Aid for Early-Career Scientists
Basic Section 44010:Cell biology-related
Kyoto University
平野咲雪
From 01 Apr. 2025, To 31 Mar. 2027, Granted
細胞間接着
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K18460/

細胞バリア機能の動的制御を介した管腔構造の自律的成長機構の解析
Grant-in-Aid for Transformative Research Areas (A)
Transformative Research Areas, Section (III)
Kyoto University
平野咲雪
From 01 Apr. 2025, To 31 Mar. 2027, Granted
管腔形成
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25H01780/

Last Updated :2026/05/11

Education

Teaching subject(s)

From 01 Apr. 2025, To 31 Mar. 2026
Special Study CourseII(Biological Sciences) 21
8724, Year-long, Faculty of Science, 12

From 01 Apr. 2025, To 31 Mar. 2026
Seminars in Biological Science B
4732, Fall, Faculty of Science, 2

From 01 Apr. 2025, To 31 Mar. 2026
Laboratory work in Biological Science E
3766, Fall, Faculty of Science, 2

From 01 Apr. 2025, To 31 Mar. 2026
Fundamental Experiments of Cellular and Molecular Biology
2729, Fall, Faculty of Science, 4

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