Basic Information

Affiliated programs (koza)

• Graduate School of Biostudies, 統合生命科学専攻　神経発生学, 特定拠点助教

Email Address

• Email Address

  toma.kenichi.5hkyoto-u.ac.jp

Professional Memberships

• From Jan. 2024, To Present

  The Association for Research in Vision and Ophthalmology (ARVO)

Academic Degree

• 23 Mar. 2010

  大阪大学修士（理学）
• 25 Sep. 2014

  神戸大学博士（理学）

Academic Resume (Undergraduate School/Majors)

• 島根大学, 生物資源科学部生命工学科, 卒業

Profile

• Profile

  2014年に神戸大学理学研究科/理研CDB大脳皮質発生研究チーム(花嶋かりなTL)で博士号取得後、研究員として同研究室に勤務。その後、2017年よりカリフォルニア大学サンフランシスコ校(UCSF)の眼科学(Ophthalmology)のXin Duan研究室に留学し、2024年7月より京都大学高等研究院 物質-細胞統合システム拠点(iCeMS)に所属。

  
  

  現在まで神経発生に興味を持ち、特に多様な神経細胞が生み出される仕組み、それらが他の細胞と連携して機能的な組織構造を生み出す仕組みに焦点を当てて研究を進めている。またそれらの知見を用い、様々な眼科疾患モデルにおいてどのようにして組織の機能を保護または再建するのかについて発展させていきたいと考えている。

ID,URL

• J-Global ID

  201101096780381390

researchmap URL

• https://researchmap.jp/tomak

Research

Research Areas

• Life sciences, Neuroscience - general

Papers

• PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain

  Naotaka Nakazawa; Gianluca Grenci; Yoshitaka Kameo; Noriko Takeda; Tsuyoshi Sawada; Junko Kurisu; Zhejing Zhang; Kenichi Toma; Taiji Adachi; Keiko Nonomura; Mineko Kengaku

  Cell Reports, Mar. 2025, Peer-reviewed

  Access this paper :

  
• Endogenous opioid signalling regulates spinal ependymal cell proliferation

  Wendy W. S. Yue; Kouki K. Touhara; Kenichi Toma; Xin Duan; David Julius

  Nature, 18 Sep. 2024, Peer-reviewed

  
• Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.

  Kenichi Toma; Mengya Zhao; Shaobo Zhang; Fei Wang; Hannah K Graham; Jun Zou; Shweta Modgil; Wenhao H Shang; Nicole Y Tsai; Zhishun Cai; Liping Liu; Guiying Hong; Arnold R Kriegstein; Yang Hu; Jakob Körbelin; Ruobing Zhang; Yaping Joyce Liao; Tyson N Kim; Xin Ye; Xin Duan

  Cell, 23 May 2024, Peer-reviewed, Lead author

  
• Cadherin-13 Maintains Retinotectal Synapses via Transneuronal Interactions.

  Angela C Matcham; Kenichi Toma; Nicole Y Tsai; Christina J Sze; Pin-Yeh Lin; Ilaria F Stewart; Xin Duan

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 Jan. 2024, Peer-reviewed

  
• Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy.

  Mengya Zhao; Kenichi Toma; Benyam Kinde; Liang Li; Amit K Patel; Kong-Yan Wu; Matthew R Lum; Chengxi Tan; Jody E Hooper; Arnold R Kriegstein; Anna La Torre; Yaping Joyce Liao; Derek S Welsbie; Yang Hu; Ying Han; Xin Duan

  Cell reports, 26 Sep. 2023, Peer-reviewed, Lead author

  
• Endogenous Opioid Signaling Regulates Proliferation of Spinal Cord Ependymal Cells.

  Wendy W S Yue; Kouki K Touhara; Kenichi Toma; Xin Duan; David Julius

  bioRxiv : the preprint server for biology, 08 Sep. 2023

  
• Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.

  Nicole Y Tsai; Fei Wang; Kenichi Toma; Chen Yin; Jun Takatoh; Emily L Pai; Kongyan Wu; Angela C Matcham; Luping Yin; Eric J Dang; Denise K Marciano; John L Rubenstein; Fan Wang; Erik M Ullian; Xin Duan

  Nature neuroscience, May 2022, Peer-reviewed

  
• Oestrogen engages brain MC4R signalling to drive physical activity in female mice.

  William C Krause; Ruben Rodriguez; Bruno Gegenhuber; Navneet Matharu; Andreas N Rodriguez; Adriana M Padilla-Roger; Kenichi Toma; Candice B Herber; Stephanie M Correa; Xin Duan; Nadav Ahituv; Jessica Tollkuhn; Holly A Ingraham

  Nature, Nov. 2021, Peer-reviewed

  
• Cadherin Combinations Recruit Dendrites of Distinct Retinal Neurons to a Shared Interneuronal Scaffold.

  Xin Duan; Arjun Krishnaswamy; Mallory A Laboulaye; Jinyue Liu; Yi-Rong Peng; Masahito Yamagata; Kenichi Toma; Joshua R Sanes

  Neuron, 19 Sep. 2018, Peer-reviewed

  
• Encoding and decoding time in neural development.

  Kenichi Toma; Tien-Cheng Wang; Carina Hanashima

  Development, growth & differentiation, Jan. 2016, Peer-reviewed, Lead author

  
• Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex.

  Kenichi Toma; Carina Hanashima

  Frontiers in neuroscience, 2015, Peer-reviewed, Lead author

  
• The timing of upper-layer neurogenesis is conferred by sequential derepression and negative feedback from deep-layer neurons.

  Kenichi Toma; Takuma Kumamoto; Carina Hanashima

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 Sep. 2014, Peer-reviewed, Lead author

  
• Importin alpha subtypes determine differential transcription factor localization in embryonic stem cells maintenance.

  Noriko Yasuhara; Ryosuke Yamagishi; Yoshiyuki Arai; Rashid Mehmood; Chihiro Kimoto; Toshiharu Fujita; Kenichi Touma; Azumi Kaneko; Yasunao Kamikawa; Tetsuji Moriyama; Toshio Yanagida; Hiroki Kaneko; Yoshihiro Yoneda

  Developmental cell, 29 Jul. 2013, Peer-reviewed

  
• Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression.

  Takuma Kumamoto; Ken-ichi Toma; Gunadi; William L McKenna; Takeya Kasukawa; Sol Katzman; Bin Chen; Carina Hanashima

  Cell reports, 28 Mar. 2013, Peer-reviewed

  
• Identification of sam4 as a rad24 Allele in Schizosaccharomyces pombe

  Yasuo Oowatari; Kenichi Toma; Fumiyo Ozoe; Makoto Kawamukai

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2009, Peer-reviewed

  

Presentations

• Perivascular Neurons Instruct Three-Dimensional Vascular Lattice Formation via Piezo2-mediated Contact.

  Toma, K.; Zhao, M.; Zhang, S.; Modgli, S.; Shang, WH; Liao, YJ; Kim, TN; Duan, X.

  ISDN 2024, 25th Biennial Meeting of the International Society for Developmental Neuroscience, 24 Sep. 2024

  
• 血管周囲ニューロンによるPiezo2依存的接触を介した3D血管パターニング機構

  當麻憲一

  立命館大学 システム視覚科学研究センターセミナー, 13 Sep. 2024, Invited

  
• Perivascular Neurons Instruct Three-Dimensional Retinal Vascular Lattice Formation via Direct Neurovascular Contact.

  Toma, K; Zhao, M; Zhang, S; Wang, F; Modgli, S; Shang, WH; Liao, YJ; Kim, TN; Duan, X

  ARVO 2024 Annual Meeting, 08 May 2024

  
• Perivascular neurons instruct 3D vascular lattice formation via Piezo2-mediated contact.

  Toma ,K; Zhao, M; Zhang, S; Graham, H; Tsai, N; Wang, F; Korbelin, J; Zhang, R; Kriegstein, A; Kim, T; Ye, X; Duan, X

  The 56th Annual Meeting of the Japanese Society of Developmental Biologists, 25 Jul. 2023

  
• Perivascular neurons direct 3D vascular scaffold formation via Piezo2-mediated contact.

  Kenichi Toma; Mengya Zhao; Shaobo Zhang; Hannah Graham; Nicole Tsai; Fei Wang; Jakob Korbelin; Ruobing Zhang; Tyson Kim; Xin Ye; Xin Duan

  Molecular Mechanisms of Neuronal Connectivity. CSHL Meeting, Sep. 2022

  
• Mechanisms that balance neuronal subtype production in the cerebral cortex.

  Toma, K; Hanashima, C

  The 40th Annual Meeting of the Japan Neuroscience Society, 20 Jul. 2017

  
• Mechanisms that balance neuronal subtype production in the cerebral cortex.

  Toma, K; Hanashima, C

  The 69th Annual Meeting of the Japan Society for Cell Biology, 15 Jun. 2017, Invited

  
• Mechanisms that balance neuronal subtype production in the developing neocortex.

  Kenichi Toma; Carina Hanashima

  Neuroscience 2016, SfN’s 46th annual meeting, Nov. 2016

  
• Mechanisms that balance neuronal subtype production in the cerebral cortex.

  Kenichi Toma; Carina Hanashima

  Neuroscience2016, The 39th Annual Meeting of the Japan Neuroscience Society, Jul. 2016

  
• Mechanisms that balance neuronal subtype production in the cerebral cortex.

  Kenichi Toma; Carina Hanashima

  CDB symposium 2016, Mar. 2016

  
• Mechanisms that balance neuronal subtype production in the cerebral cortex.

  Kenichi Toma; Carina Hanashima

  Neocortical Organization III, Feb. 2016

  
• A two-step regulatory mechanism determine the timing of upper-layer neurogenesis in the cerebral cortex.

  Kenichi Toma; Takuma Kumamoto; Carina Hanashima

  Neuroscience2015, The 38th Annual Meeting of the Japan Neuroscience Society, Jul. 2015

  
• Identification and Characterization of Neuron-specific RNA-binding protein Nova1 in neocortical development.

  Tieng-Cheng Wang; Ken-ichi Toma; Carina Hanashima

  Neuroscience2014, The 37th Annual Meeting of the Japan Neuroscience Society, Sep. 2014

  
• Mechanisms that determine the timing of upper-layer neurogenesis in the neocortex.

  Ken-ichi Toma; Takuma Kumamoto; Carina Hanashima

  Neuroscience2014, The 37th Annual Meeting of the Japan Neuroscience Society, Sep. 2014

  
• Mechanisms that determine the timing of upper-layer neurogenesis in the cerebral cortex.

  Toma Ken-ichi; Kumamoto Takuma; Hanashima Carina

  Cortical Development 2014, 2014

  
• Foxg1 directs the specification of upper-layer projection neurons in late neocortical progenitors.

  Ken-ichi Toma; Takuma Kumamoto; Carina Hanashima

  Neuro2013, The 36th Annual Meeting of the Japan Neuroscience Society, Jun. 2013

  
• Foxg1 directs the specification of upper-layer projection neurons in late neocortical progenitors.

  Toma, K; Kumamoto, T; Chen, B; Hanashima, C

  Neuroscience 2012, SfN’s 42nd annual meeting, 14 Oct. 2012

  
• Foxg1 is required in late mouse neocortical progenitors to direct differentiation of upper-layer projection neurons.

  Ken-ichi Toma; Takuma Kumamoto; Carina Hanashima

  ISSCR2012, The ISSCR 10th Annual Meeting, Jun. 2012

  
• Foxg1 regulates the onset of projection neuron production in the cerebral cortex.

  Takuma Kumamoto; Ken-ichi Toma; Gunadi; Will McKenna; Takeya Kasukawa; Bin Chen; Carina Hanashia

  1st International symposium: Neocortical Organization, Mar. 2012

  
• Foxg1 is required for the specification of upper-layer neurons in the neocortex.

  Ken-ichi Toma; Takuma Kumamoto; Carina Hanashima

  MBSJ2011, The 34th Annual Meeting of the Molecular Biology Society of Japan, Dec. 2011

  
• Molecular mechanisms of upper-layer neuron specification in the developing neocortex.

  Ken-ichi Toma; Takuma Kumamoto; Carina Hanashima

  The exciting biology meeting on “Cellular development: Biology at the interface”, Oct. 2011

  
• Molecular mechanisms of upper-layer neuron specification in mouse neocortex.

  Ken-ichi Toma; Yuko Gonda; Ken-ichi Mizutani; Carina Hanashima

  Neuroscience2011, The 34th Annual Meeting of the Japan Neuroscience Society, Sep. 2011

  
• Foxg1 coordinates the timing of projection neuron production in the cerebral cortex.

  Carina Hanashima; Takuma Kumamoto; Ken-ichi Toma

  Neuroscience2011, The 34th Annual Meeting of the Japan Neuroscience Society, Sep. 2011

  
• Foxg1 regulates the onset of projection neuron production in the neocortex.

  Takuma Kumamoto; Ken-ichi Toma; Ken-ichi Mizutani; Carina Hanashima

  44th Annual Meeting of the Japanese Society of Developmental Biologists, May 2011

  
• Molecular identity of temporal neuronal precursors in the mouse neocortex.

  Ken-ichi Toma; Ken-ichi Mizutani; Yuko Gonda; Carina Hanashima

  BMB2010, Biochemistry and Molecular Biology, Dec. 2010

  
• Molecular identity of temporal neuronal precursors in the mouse neocortex.

  Ken-ichi Toma; Ken-ichi Mizutani; Yuko Gonda; Carina Hanashima

  Neuro2010, the 33rd Annual Meeting of the Japan Neuroscience Society, Sep. 2010

  
• Complementarity among importin-subtypes.

  Sakiko Ando; Noriko Yasuhara; Yasunao Kamikawa; Kenichi Toma; Yoneda Yoshihiro

  Annual Meeting of Japan Society for Cell Biology, Jun. 2009

  
• 分裂酵母の有性生殖過程を昂進させるsam変異株の解析

  當麻憲一; 吉本 光平; 大渡康夫; 中川強; 川向誠

  第25回イーストワークショップ, 17 Nov. 2007

  
• 分裂酵母の有性生殖過程を昂進させるsam変異株の解析

  當麻憲一; 吉本 光平; 大渡康夫; 片山諭; 川向誠

  日本農芸化学会 中四国・西日本支部合同大会 （第19回講演会）, 15 Sep. 2007

  

Books and Other Publications

• 血管周囲ニューロンはPiezo2依存的に血管に接触することによって三次元血管パターニングを制御している -実験医学 Vol.42 No.19

  當麻憲一

  羊土社, Dec. 2024

  

Awards

• 18 Aug. 2016

  JNS-SfN Exchange Travel Award（The Japan Neuroscience Society）
• 25 May 2023

  Best Poster Award（University of California San Francisco）
• 08 Oct. 2013

  Young Investigator’s Award（RIKEN CDB Retreat 2013）
• 17 Nov. 2007

  ベストポスター賞（第25回イーストワークショップ）
• 02 Nov. 2011

  Young Investigator’s Award（RIKEN CDB Retreat 2011）
• 18 Sep. 2012

  Biology / Medical Science Prize（RIKEN Noyori Summer School 2012）

External funds: Kakenhi

• Mechanisms that balance neuronal subtype production in the developing neocortex

  Grant-in-Aid for Young Scientists (B)

  Institute of Physical and Chemical Research

  Kenichi Toma

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  細胞分化;細胞間シグナル;大脳皮質;神経幹細胞;上層ニューロン;核輸送;細胞接触

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18548/
• 血管周囲ニューロンによる細胞接触を介した三次元血管パターニング機構の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 48010:Anatomy-related

  Kyoto University

  當麻 憲一

  From 01 Apr. 2025, To 31 Mar. 2029, Granted

  血管周囲ニューロン;Piezo2;網膜神経節細胞;三次元血管網;虚血性視神経症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K02433/