Basic Information

Email Address

• Email Address

  kinoshita.masaharu.6ikyoto-u.ac.jp

Academic Degree

• 25 Mar. 1994

  筑波大学修士（医科学）
• 23 Mar. 1998

  筑波大学博士（医学）

Profile

• Profile

  筑波大学生物学類卒
  筑波大学医学研究科卒(Ph.D.)
  生理学研究所リサーチアソシエイト（小松英彦教授）
  米Rockefeller Univ., Research associate (Prof. Charles Gilbert)
  生理学研究所特任助教（伊佐正教授）
  弘前大学大学院 医学研究科 統合機能生理学講座 准教授

  
  

  京都大学大学院医学研究科 高次脳科学講座 神経生物学分野 特定准教授

ID,URL

• ORCID ID

  0000-0001-8588-843X

• J-Global ID

  201101072176264176

• Researcher number

  60599083

researchmap URL

• https://researchmap.jp/mkino

Research

Research Interests

• 包括脳ネットワーク
• 脳プロ

Research Areas

• Life sciences, Neuroscience - general

Papers

• Phylogenetic view of the compensatory mechanisms in motor and sensory systems after neuronal injury

  Tadashi Isa; Takamichi Tohyama; Masaharu Kinoshita

  Current Research in Neurobiology, 17 Oct. 2022

  Access this paper :

  
• Dissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus

  Masaharu Kinoshita; Rikako Kato; Kaoru Isa; Kenta Kobayashi; Kazuto Kobayashi; Hirotaka Onoe; Tadashi Isa

  Nature Communications, 11 Jan. 2019, Peer-reviewed

  
• Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration.

  Hung-Ya Tu; Takehito Watanabe; Hiroshi Shirai; Suguru Yamasaki; Masaharu Kinoshita; Keizo Matsushita; Tomoyo Hashiguchi; Hirotaka Onoe; Take Matsuyama; Atsushi Kuwahara; Akiyoshi Kishino; Toru Kimura; Mototsugu Eiraku; Kiyoshi Suzuma; Takashi Kitaoka; Masayo Takahashi; Michiko Mandai

  EBioMedicine, Jan. 2019, Peer-reviewed

  
• Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys

  Takamichi Tohyama; Masaharu Kinoshita; Kenta Kobayashi; Kaoru Isa; Dai Watanabe; Kazuto Kobayashi; Meigen Liu; Tadashi Isa

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2017, Peer-reviewed

  
• Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex

  Akiya Watakabe; Masanari Ohtsuka; Masaharu Kinoshita; Masafumi Takaji; Kaoru Isa; Hiroaki Mizukami; Keiya Ozawa; Tadashi Isa; Tetsuo Yamamori

  NEUROSCIENCE RESEARCH, Apr. 2015, Peer-reviewed

  
• Potential of optogenetics for the behavior manipulation of non-human primates

  Masaharu Kinoshita; Tadashi Isa

  Optogenetics: Light-Sensing Proteins and their Applications, 01 Jan. 2015

  
• Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice

  Thongchai Sooksawate; Kaoru Isa; Ryosuke Matsui; Shigeki Kato; Masaharu Kinoshita; Kenta Kobayashi; Dai Watanabe; Kazuto Kobayashi; Tadashi Isa

  Frontiers in Neural Circuits, 11 Oct. 2013, Peer-reviewed

  
• Role of direct vs. indirect pathways from the motor cortex to spinal motoneurons in the control of hand dexterity

  Tadashi Isa; Masaharu Kinoshita; Yukio Nishimura

  FRONTIERS IN NEUROLOGY, 2013, Peer-reviewed

  
• DNA methylation and methyl-binding proteins control differential gene expression in distinct cortical areas of macaque monkey

  Katsusuke Hata; Hiroaki Mizukami; Osamu Sadakane; Akiya Watakabe; Masanari Ohtsuka; Masafumi Takaji; Masaharu Kinoshita; Tadashi Isa; Keiya Ozawa; Tetsuo Yamamori

  Journal of Neuroscience, 2013, Peer-reviewed

  
• Genetic dissection of the circuit for hand dexterity in primates

  Masaharu Kinoshita; Ryosuke Matsui; Shigeki Kato; Taku Hasegawa; Hironori Kasahara; Kaoru Isa; Akiya Watakabe; Tetsuo Yamamori; Yukio Nishimura; Bror Alstermark; Dai Watanabe; Kazuto Kobayashi; Tadashi Isa

  NATURE, Jul. 2012, Peer-reviewed

  
• Optical Imaging of Contextual Interactions in V1 of the Behaving Monkey

  Masaharu Kinoshita; Charles D. Gilbert; Aniruddha Das

  JOURNAL OF NEUROPHYSIOLOGY, Sep. 2009, Peer-reviewed

  
• Representation of surface luminance and brightness in macaque visual cortex.

  Komatsu, H; Kinoshita, M

  Neural Basis of Early Vision, 2003, Peer-reviewed

  
• Surface representation in the monkey primary visual cortex (VI)

  H Komatsu; M Kinoshita

  COGNITION AND EMOTION IN THE BRAIN, 2003, Peer-reviewed

  
• Neural responses in the primary visual cortex of the monkey during perceptual filling-in at the blind spot

  H Komatsu; M Kinoshita; Murakami, I

  NEUROSCIENCE RESEARCH, Nov. 2002, Peer-reviewed

  
• Neural representation of the luminance and brightness of a uniform surface in the macaque primary visual cortex

  M Kinoshita; H Komatsu

  JOURNAL OF NEUROPHYSIOLOGY, Nov. 2001, Peer-reviewed

  
• Stimulus time-locked responses of motoneurons during forelimb fictive locomotion evoked by repetitive stimulation of the lateral funiculus

  M Kinoshita; T Yamaguchi

  BRAIN RESEARCH, Jun. 2001, Peer-reviewed

  
• Neural responses in the retinotopic representation of the blind spot in the macaque V1 to stimuli for perceptual filling-in

  H Komatsu; M Kinoshita; Murakami, I

  JOURNAL OF NEUROSCIENCE, Dec. 2000, Peer-reviewed

  
• Perceptual filling-in at the scotoma following a monocular retinal lesion in the monkey

  Murakami, I; H Komatsu; M Kinoshita

  VISUAL NEUROSCIENCE, Jan. 1997, Peer-reviewed

  
• Surface representation in the visual system

  H Komatsu; Murakami, I; M Kinoshita

  BRAIN AND MIND, 1997, Peer-reviewed

  
• Surface representation in the visual system

  H Komatsu; Murakami, I; M Kinoshita

  COGNITIVE BRAIN RESEARCH, Dec. 1996, Peer-reviewed

  

Misc.

• Transplantation of human induced pluripotent stem cell-derived retinal tissue in primate models of retinal degeneration with perimetric analysis

  Hiroshi Shirai; Michiko Mandai; Masaharu Kinoshita; Hirotaka Onoe; Keizo Matsushita; Atsushi Kuwahara; Suguru Yamasaki; Hiroko Terasaki; Yoshiki Sasai; Masayo Takahashi

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Sep. 2016

  
• Selective blockade of crossed tecto-reticular pathway by double infection of viral vectors impaired orienting responses in mice; methodological considerations.

  伊佐かおる; Thongchai Sooksawate; 松井亮介; 加藤成樹; 木下正治; 小林憲太; 渡邉大; 小林和人; 伊佐正

  第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会. P1-2-244, 京都, Jun. 2013

  
• Optogenetic suppression of forelimb muscle activities in the behaving macaque monkey by introduction of microbial opsins in the primary motor cortex.

  木下正治; 笠原洋紀; 畑中伸彦; 松井亮介; 知見聡美; 伊佐かおる; 水上浩明; 小澤敬也; 南部篤; 渡邉大; 伊佐正

  第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会. P3-2-242, 京都, Jun. 2013

  
• Verified contribution of propriospinal neurons to recovery of hand dexterity after a corticospinal tract lesion in the monkey.

  當山峰道; 木下正治; 松井亮介; 加藤成樹; 長谷川拓; 笠原洋紀; 伊佐かおる; 渡邉大; 小林和人; 里宇明元; 伊佐正

  第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会. P1-1-74, 京都, Jun. 2013

  
• Optogenetics in primates

  木下 正治; 伊佐 正

  生体の科学, Jan. 2013

  
• ウイルスベクター二重感染法による選択的神経伝達遮断により明らかにした、マカクザル前肢巧緻運動における脊髄固有ニューロンの機能.

  木下正治; 松井亮介; 加藤成樹; 長谷川拓; 笠原洋紀; 伊佐かおる; 渡我部昭哉; 山森哲雄; 西村幸男; BrorAlstermark; 渡邉大; 小林和人; 伊佐正

  第59回中部日本生理学会. P19, 岡崎, Nov. 2012

  
• ウイルスベクター 2 重感染法によるマウス指向運動に関する神経経路の選択的・可逆的制御.

  伊佐かおる; ThongchaiSooksawate; 木下正治; 松井亮介; 加藤成樹; 渡辺大; 小林和人; 伊佐正

  第3回名古屋大学・生理学研究所合同シンポジウム, 岡崎, Sep. 2012

  
• Genetic dissection of the spinal circuit for hand dexterity in macaque monkeys.

  Masaharu Kinoshita; Ryosuke Matsui; Shigeki Kato; Taku Hasegawa; Hironori Kasahara; Kaoru Isa; Akiya Watakabe; Tetsuo Yamamori; Yukio Nishimura; Bror Alstermark; Dai Watanabe; Kazuto Kobayashi; Tadashi Isa

  8th FENS Forum of Neuroscience. 155.04, Barcelona, Spain, Jul. 2012

  
• Disturbance of reaching-grasping induced by the pathway-specific blockade of the signal transmission through the mid-cervical propriospinal neurons in macaque monkeys.

  Masaharu Kinoshita; Ryosuke Matsui; Shigeki Kato; Hironori Kasahara; Kaoru Isa; Yukio Nishimura; Dai Watanabe; Kazuto Kobayashi; Tadashi Isa

  第34回日本神経科学大会. O4-H-1-2, 横浜, Nov. 2011

  
• Expression of halorhodopsin for suppression of neuronal transmission in the central nervous system of the mouse and monkey with viral vectors.

  Masaharu Kinoshita; Katsuyuki Kaneda; Hironori Kasahara; Nobuhiko Hatanaka; Ryosuke Matsui; Satomi Chiken; Kaoru Isa; Hiroaki Mizukami; Keiya Ozawa; Dai Watanabe; Atsushi Nambu; Tadashi Isa

  第16回日本遺伝子治療学会. PO-104, 宇都宮, Jul. 2010

  
• Optogenetically induced suppression of neural activity in the macaque motor cortex

  Kinoshita, Masaharu; Kaneda, Katsuyuki; Kasahara, Hironori; Hatanaka, Nobuhiko; Matsui, Ryosuke; Chiken, Satomi; Isa, Kaoru; Mizukami, Hiroaki; Ozawa, Keiya; Watanabe, Dai; Nambu, Atsushi; Isa, Tadashi

  NEUROSCIENCE RESEARCH, 2010

  

Awards

• 23 Jan. 2013

  第２回自然科学研究機構若手研究者賞

External funds: Kakenhi

• 光遺伝学を非ヒト霊長類に応用して経路選択的な神経伝達の操作を実現する

  Grant-in-Aid for Scientific Research (C)

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  木下 正治

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  光遺伝学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09654/
• Blockade of specific neural pathway in non human primates brain by using optogenetic method.

  Grant-in-Aid for Scientific Research (C)

  Basic Section 46010:Neuroscience-general-related

  Hirosaki University

  MASAHARU KINOSHITA

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  ウイルスベクター;マカクザル;光遺伝学;optogenetics

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06880/
• A new artificial scotoma model by optogenetics and neural mechanisms of perceptual filling in

  Grant-in-Aid for Scientific Research (C)

  Hirosaki University

  Masaharu Kinoshita

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  ウイルスベクター;マカクザル;視覚情報処理;gene introduction;macaque monkey;neural pathway;光遺伝学;知覚的充填;神経科学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K06983/
• 光遺伝学を用いた霊長類の視覚－運動変換系の神経経路選択的な伝達遮断法の確立

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Hirosaki University

  木下 正治

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  経路選択的神経伝達遮断;霊長類;ウイルスベクター;盲視;神経科学;視覚情報処理;マカクザル;光遺伝学

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01411/
• Identification of functional role of neural networks between basal ganglia and cerebral cortex by optogenetics

  Grant-in-Aid for Challenging Exploratory Research

  Hirosaki University

  Kiyoshi Kurata

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  basal ganglia;cerebellum;motor control;reaching;neuronal activity;optogenetics;オプトジェネティクス;大脳基底核連関;随意運動;ニューロン活動;光遺伝学;ニホンザル;大脳基底核;大脳皮質;運動制御;行動選択

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26640001/
• Study about the superior colliculus related neural pathway for blindsight by using new genetic method

  Grant-in-Aid for Scientific Research (C)

  Hirosaki University

  Masaharu Kinoshita

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  盲視;視床枕;上丘;マカクザル;遺伝子導入;サッケード;ウイルスベクター;神経経路

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25430023/