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Mino, Takashi

Graduate School of Medicine, Medicine Assistant Professor

Mino, Takashi
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    Last Updated :2022/09/13

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Medicine, 医学専攻 感染防御生物学, 助教
    • Graduate School of Medicine, 医科学専攻 感染防御生物学, 助教

    Faculty

    • 医学部

    Professional Memberships

    • 日本RNA学会
    • 日本免疫学会

    Academic Degree

    • Master of Engineering(Kyoto University)
    • Ph.D. in Engineering(Kyoto University)

    Research History

    • From Apr. 2019, To Present
      Kyoto University, Graduate School of Medicine, Assistant Professor
    • From Oct. 2016, To Mar. 2019
      Kyoto University, Institute for Frontier Life and Medical Sciences, Assistant Professor
    • From Jun. 2012, To Sep. 2016
      Kyoto University, Institute for Virus Research, Assistant Professor
    • From Apr. 2010, To Jun. 2012
      Osaka University, WPI Immunology Frontier Research Center, Specially Appointed Researcher
    • From Apr. 2009, To Mar. 2010
      The University of California, San Diego, School of Medicine, Postdoctoral Fellow
    • From Apr. 2007, To Mar. 2009
      Kyoto University, Graduate School of Engineering Department of Synthetic Chemistry and Biological Chemistry, JSPS Research Fellow

    ID,URL

    researchmap URL

    list
      Last Updated :2022/09/13

      Research

      Research Topics, Overview of the research

      • Research Topics

        Post-transcriptional Regulation of Innate Immune System
      • Overview of the research

        Cytokines are critical mediators of inflammation and host defense. Cytokine production is regulated during transcription and post-transcription. Post-transcriptional regulation modifies mRNA stability and translation, allowing for the rapid and flexible control of gene expression, which is important for coordinating the initiation and resolution of inflammation. We investigate mechanisms of post-transcriptional regulation that regulate inflammation.

      Research Interests

      • Cytokine
      • Translation
      • RNA degradation
      • Post-transcriptional regulation
      • Immunology

      Research Areas

      • Life sciences, Molecular biology
      • Life sciences, Medical biochemistry
      • Life sciences, Immunology

      Papers

      • Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.
        Ai Yaku; Tadakatsu Inagaki; Ryotaro Asano; Makoto Okazawa; Hiroyoshi Mori; Ayuko Sato; Fabian Hia; Takeshi Masaki; Yusuke Manabe; Tomohiko Ishibashi; Alexis Vandenbon; Yoshinari Nakatsuka; Kotaro Akaki; Masanori Yoshinaga; Takuya Uehata; Takashi Mino; Satoshi Morita; Hatsue Ishibashi-Ueda; Akio Morinobu; Tohru Tsujimura; Takeshi Ogo; Yoshikazu Nakaoka; Osamu Takeuchi
        Circulation, 23 Aug. 2022, Peer-reviewed
      • DSP-crosslinking and Immunoprecipitation to Isolate Weak Protein Complex
        Kotaro Akaki; Takashi Mino; Osamu Takeuchi
        BIO-PROTOCOL, Aug. 2022, Peer-reviewed
      • Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases.
        Ka Man Tse; Alexis Vandenbon; Xiaotong Cui; Takashi Mino; Takuya Uehata; Keiko Yasuda; Ayuko Sato; Tohru Tsujimura; Fabian Hia; Masanori Yoshinaga; Makoto Kinoshita; Tatsusada Okuno; Osamu Takeuchi
        Science translational medicine, 11 May 2022
      • Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism.
        Yee Kien Chong; Sarang Tartey; Yuki Yoshikawa; Koshi Imami; Songling Li; Masanori Yoshinaga; Ai Hirabayashi; Guohao Liu; Alexis Vandenbon; Fabian Hia; Takuya Uehata; Takashi Mino; Yutaka Suzuki; Takeshi Noda; Dominique Ferrandon; Daron M Standley; Yasushi Ishihama; Osamu Takeuchi
        Science signaling, 12 Apr. 2022
      • IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay
        Kotaro Akaki; Kosuke Ogata; Yuhei Yamauchi; Noriki Iwai; Ka Man Tse; Fabian Hia; Atsushi Mochizuki; Yasushi Ishihama; Takashi Mino; Osamu Takeuchi
        eLife, 12 Oct. 2021
      • Regnase-1-related endoribonucleases in health and immunological diseases.
        Takashi Mino; Osamu Takeuchi
        Immunological reviews, 12 Sep. 2021
      • Extracellular mRNA transported to the nucleus exerts translation-independent function.
        Takeshi Tomita; Masayoshi Kato; Taishi Mishima; Yuta Matsunaga; Hideki Sanjo; Ken-Ichi Ito; Kentaro Minagawa; Toshimitsu Matsui; Hiroyuki Oikawa; Satoshi Takahashi; Toshifumi Takao; Noriki Iwai; Takashi Mino; Osamu Takeuchi; Yoshiro Maru; Sachie Hiratsuka
        Nature communications, 16 Jun. 2021
      • Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1
        Yoshinari Nakatsuka; Ai Yaku; Tomohiro Handa; Alexis Vandenbon; Yuki Hikichi; Yasutaka Motomura; Ayuko Sato; Masanori Yoshinaga; Kiminobu Tanizawa; Kizuku Watanabe; Toyohiro Hirai; Kazuo Chin; Yutaka Suzuki; Takuya Uehata; Takashi Mino; Tohru Tsujimura; Kazuyo Moro; Osamu Takeuchi
        European Respiratory Journal, 25 Sep. 2020, Peer-reviewed
      • N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation
        Daichi Yamasoba; Kei Sato; Takuya Ichinose; Tomoko Imamura; Lennart Koepke; Simone Joas; Elisabeth Reith; Dominik Hotter; Naoko Misawa; Kotaro Akaki; Takuya Uehata; Takashi Mino; Sho Miyamoto; Takeshi Noda; Akio Yamashita; Daron M. Standley; Frank Kirchhoff; Daniel Sauter; Yoshio Koyanagi; Osamu Takeuchi
        Nature Microbiology, Sep. 2019, Peer-reviewed
      • Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs
        Takashi Mino; Noriki Iwai; Masayuki Endo; Kentaro Inoue; Kotaro Akaki; Fabian Hia; Takuya Uehata; Tomoko Emura; Kumi Hidaka; Yutaka Suzuki; Daron M Standley; Mariko Okada-Hatakeyama; Shigeo Ohno; Hiroshi Sugiyama; Akio Yamashita; Osamu Takeuchi
        Nucleic Acids Research, 22 Jul. 2019, Peer-reviewed, Lead author
      • Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.
        Yoshinari Nakatsuka; Alexis Vandenbon; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Xiaotong Cui; Ayuko Sato; Tohru Tsujimura; Yutaka Suzuki; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Teiji Sawa; Toyohiro Hirai; Osamu Takeuchi
        Mucosal immunology, Jul. 2018, Peer-reviewed
      • Post-transcriptional regulation of immune responses by RNA binding proteins
        Takashi Mino; Osamu Takeuchi
        Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 2018, Peer-reviewed
      • NSD3 keeps IRF3 active
        Takashi Mino; Osamu Takeuchi
        JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 2017, Peer-reviewed, Invited
      • Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis
        Xiaotong Cui; Takashi Mino; Masanori Yoshinaga; Yoshinari Nakatsuka; Fabian Hia; Daichi Yamasoba; Tohru Tsujimura; Keizo Tomonaga; Yutaka Suzuki; Takuya Uehata; Osamu Takeuchi
        JOURNAL OF IMMUNOLOGY, Dec. 2017, Peer-reviewed
      • Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase- Domain-Containing Protein 3 mRNAs
        Masanori Yoshinaga; Yoshinari Nakatsuka; Alexis Vandenbon; Daisuke Ori; Takuya Uehata; Tohru Tsujimura; Yutaka Suzuki; Takashi Mino; Osamu Takeuchi
        CELL REPORTS, May 2017, Peer-reviewed
      • Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin
        Takashi Mino; Osamu Takeuchi
        Folia Pharmacologica Japonica, 2016, Peer-reviewed
      • Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses
        Sarang Tartey; Kazufumi Matsushita; Tomoko Imamura; Atsuko Wakabayashi; Daisuke Ori; Takashi Mino; Osamu Takeuchi
        JOURNAL OF IMMUNOLOGY, Jul. 2015, Peer-reviewed
      • Regnase-1 and Roquin regulate inflammatory mRNAs
        Takashi Mino; Osamu Takeuchi
        ONCOTARGET, Jul. 2015, Peer-reviewed, Invited
      • Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms
        Takashi Mino; Yasuhiro Murakawa; Akira Fukao; Alexis Vandenbon; Hans-Hermann Wessels; Daisuke Ori; Takuya Uehata; Sarang Tartey; Shizuo Akira; Yutaka Suzuki; Carola G. Vinuesa; Uwe Ohler; Daron M. Standley; Markus Landthaler; Toshinobu Fujiwara; Osamu Takeuchi
        CELL, May 2015, Peer-reviewed
      • Akirin2 is critical for inducing inflammatory genes by bridging I kappa B-zeta and the SWI/SNF complex
        Sarang Tartey; Kazufumi Matsushita; Alexis Vandenbon; Daisuke Ori; Tomoko Imamura; Takashi Mino; Daron M. Standley; Jules A. Hoffmann; Jean-Marc Reichhart; Shizuo Akira; Osamu Takeuchi
        EMBO JOURNAL, Oct. 2014, Peer-reviewed
      • Inhibition of DNA Replication of Human Papillomavirus by Using Zinc Finger-Single-Chain FokI Dimer Hybrid
        Takashi Mino; Tomoaki Mori; Yasuhiro Aoyama; Takashi Sera
        MOLECULAR BIOTECHNOLOGY, Aug. 2014, Peer-reviewed
      • Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo
        Kazuya Masuda; Barry Ripley; Riko Nishimura; Takashi Mino; Osamu Takeuchi; Go Shioi; Hiroshi Kiyonari; Tadamitsu Kishimoto
        Proceedings of the National Academy of Sciences of the United States of America, 04 Jun. 2013, Peer-reviewed
      • Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation
        Masahiro Fukasaka; Daisuke Ori; Tatsukata Kawagoe; Satoshi Uematsu; Kenta Maruyama; Toshihiko Okazaki; Tatsuya Kozaki; Tomoko Imamura; Sarang Tartey; Takashi Mino; Takashi Satoh; Shizuo Akira; Osamu Takeuchi
        JOURNAL OF IMMUNOLOGY, Jun. 2013, Peer-reviewed
      • Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.
        Takuya Uehata; Hidenori Iwasaki; Alexis Vandenbon; Kazufumi Matsushita; Eduardo Hernandez-Cuellar; Kanako Kuniyoshi; Takashi Satoh; Takashi Mino; Yutaka Suzuki; Daron M Standley; Tohru Tsujimura; Hiromi Rakugi; Yoshitaka Isaka; Osamu Takeuchi; Shizuo Akira
        Cell, 23 May 2013, Peer-reviewed
      • Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs
        Daisuke Ori; Hiroki Kato; Hideki Sanjo; Sarang Tartey; Takashi Mino; Shizuo Akira; Osamu Takeuchi
        JOURNAL OF IMMUNOLOGY, Apr. 2013, Peer-reviewed
      • Gene- and Protein-Delivered Zinc Finger-Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus
        Takashi Mino; Tomoaki Mori; Yasuhiro Aoyama; Takashi Sera
        PLOS ONE, Feb. 2013, Peer-reviewed
      • Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation
        Takashi Mino; Osamu Takeuchi
        BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 2013, Peer-reviewed
      • Post-transcriptional regulation controls the initiation and resolution of innate immune response
        三野享史; 竹内理
        医学のあゆみ, 06 Oct. 2012, Peer-reviewed
      • Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
        Ping-Hui Tseng; Atsushi Matsuzawa; Weizhou Zhang; Takashi Mino; Dario A. A. Vignali; Michael Karin
        NATURE IMMUNOLOGY, Jan. 2010, Peer-reviewed
      • Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer
        Takashi Mino; Yasuhiro Aoyama; Takashi Sera
        JOURNAL OF BIOTECHNOLOGY, Mar. 2009, Peer-reviewed
      • Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses
        Takashi Mino; Tomoaki Mori; Yasuhiro Aoyama; Takashi Sera
        ARCHIVES OF VIROLOGY, Jul. 2008, Peer-reviewed
      • Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases.
        T. Mino; T. Mori; Y. Aoyama; T. Sera
        Nucleic acids symposium series, 2008, Peer-reviewed
      • Development of protein-based antiviral drugs for human papillomaviruses.
        T. Mino; T. Mori; Y. Aoyama; T. Sera
        Nucleic acids symposium series, 2007, Peer-reviewed
      • Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins
        T Mino; T Hatono; N Matsumoto; T Mori; Y Mineta; Y Aoyama; T Sera
        JOURNAL OF VIROLOGY, Jun. 2006, Peer-reviewed
      • Application of artificial zinc-finger proteins to inhibition of DNA replication of human papillomavirus.
        Mino T; Mori T; Matsumoto N; Mineta Y; Okamoto T; Aoyama Y; Sera T
        Nucleic Acids Symposium Series, 2006, Peer-reviewed

      Misc.

      • Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity
        Yoshinari Nakatsuka; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Toyohiro Hirai Hirai; Osamu Takeuchi
        CYTOKINE, Dec. 2017
      • Regnase-1は翻訳に依存して炎症関連mRNAを分解する
        三野享史; 深尾亜喜良; 藤原俊伸; 竹内理
        日本分子生物学会年会プログラム・要旨集(Web), 2014
      • Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo
        Kazuya Masuda; Barry Ripley; Riko Nishimura; Takashi Mino; Osamu Takeuchi; Go Shioi; Hiroshi Kiyonari; Tadamitsu Kishimoto
        CYTOKINE, Sep. 2013

      Industrial Property Rights

      • 特開2019-073466, 特願2017-199591, IMMUNOSTIMULANTS
        竹内 理; 三野 享史; 山下 暁朗

      External funds: Kakenhi

      • Study of mRNA translation in immune system
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49070:Immunology-related
        Kyoto University
        三野 享史
        From 01 Apr. 2019, To 31 Mar. 2022, Granted
        免疫;翻訳;mRNA分解;Regnase-1;UPF1;自然免疫;サイトカイン;転写後制御;リボソーム;mRNA
      • Analysis of immune regulatory mechanisms mediated by mRNA metabolism
        Grant-in-Aid for Scientific Research (S)
        Broad Section H
        Kyoto University
        竹内 理
        From 11 Jun. 2018, To 31 Mar. 2023, Granted
        免疫応答;mRNA分解;mRNA修飾;サイトカイン;自然免疫応答;mRNA制御;mRNA分解;免疫制御
      • Study of UPF1-mediated mRNA regulation in immune system
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Takashi MINO
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        自然免疫;サイトカイン;転写後制御;mRNA分解;UPF1;Regnase-1;TTP;翻訳;mRNA安定性制御
      • Analysis of posttranscriptional mechanisms of Regnase-1-mediated mRNA decay in innate immune system
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Takashi MINO
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        自然免疫;炎症;サイトカイン;転写後調節;RNA安定性制御;Regnase-1;Ribosome;UPF1
      list
        Last Updated :2022/09/13

        Education

        Teaching subject(s)

        • From Apr. 2016, To Mar. 2017
          ILAS Seminar
          Spring, 全学共通科目
        list
          Last Updated :2022/09/13

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2014, To 31 Mar. 2017
            共同利用機器等委員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2017
            化学物質管理委員会 委員
          • From 01 Oct. 2016
            (旧ウイルス研)共同利用機器等委員会 委員
          • From 01 Oct. 2016
            化学物質管理委員会 委員
          • From 01 Apr. 2018
            共同利用機器等委員会

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