Basic Information

Email Address

• Email Address

  motani.sayuri.6wkyoto-u.ac.jp

Professional Memberships

• From Apr. 2015

  日本生化学会

Academic Degree

• 26 Mar. 2012

  京都大学修士（医科学）
• 23 Mar. 2016

  京都大学博士（医科学）

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士後期課程医科学専攻, 修了
• 京都大学, 大学院医学研究科修士課程医科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• The University of Sydney, Bachelor of Science (Molecular Biology and Genetics), 卒業

Research History

• From Apr. 2018, To Mar. 2023

  Kyoto University, Institute for the Advanced Study of Human Biology (ASHBi), Mitinori Saitou group, Program-Specific Researcher (Specially Promoted Research)
• From Apr. 2016, To Mar. 2018

  Osaka University, WPI Immunology Frontier Research Center, Biochemistry and Immunology, Specially Appointed Researcher (Full time)
• From Apr. 2014, To Mar. 2016

  Japan Society for the Promotion of Science, Doctoral Course (DC) Research Fellowships (DC2)
• From May 2013, To Mar. 2014

  Kyoto University, Global COE programs, "Center for Frontier Medicine", Research assistant (RA)
• From Apr. 2013, To Apr. 2013

  Kyoto University, Graduate School of Medicine, Department of Medical Chemistry, Office assistant (OA)

ID,URL

• J-Global ID

  202301015807778965

• Researcher number

  30792428

researchmap URL

• https://researchmap.jp/sayuri_gyobumotani

Research

Research Areas

• Life sciences, Molecular biology
• Life sciences, Cell biology

Papers

• Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys.

  Sayuri Gyobu-Motani; Yukihiro Yabuta; Ken Mizuta; Yoshitaka Katou; Ikuhiro Okamoto; Masanori Kawasaki; Ayaka Kitamura; Tomoyuki Tsukiyama; Chizuru Iwatani; Hideaki Tsuchiya; Taro Tsujimura; Takuya Yamamoto; Tomonori Nakamura; Mitinori Saitou

  The EMBO journal, 16 Mar. 2023

  
• Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys†

  Yoshitake Sakai; Tomonori Nakamura; Ikuhiro Okamoto; Sayuri Gyobu-Motani; Hiroshi Ohta; Yukihiro Yabuta; Tomoyuki Tsukiyama; Chiduru Iwatani; Hideaki Tsuchiya; Masatsugu Ema; Asuka Morizane; Jun Takahashi; Takuya Yamamoto; Mitinori Saitou

  Biology of Reproduction, 13 Nov. 2019, Peer-reviewed

  
• Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution

  Takuma Tsuji; Jinglei Cheng; Tsuyako Tatematsu; Aoi Ebata; Hiroki Kamikawa; Akikazu Fujita; Sayuri Gyobu; Katsumori Segawa; Hiroyuki Arai; Tomohiko Taguchi; Shigekazu Nagata; Toyoshi Fujimoto

  Proceedings of the National Academy of Sciences, 19 Jun. 2019, Peer-reviewed

  
• Characterization of the scrambling domain of the TMEM16 family

  Sayuri Gyobu; Kenji Ishihara; Jun Suzuki; Katsumori Segawa; Shigekazu Nagata

  Proceedings of the National Academy of Sciences, 30 May 2017, Peer-reviewed, Lead author

  
• A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility

  Sayuri Gyobu; Haruhiko Miyata; Masahito Ikawa; Daiju Yamazaki; Hiroshi Takeshima; Jun Suzuki; Shigekazu Nagata

  Molecular and Cellular Biology, 15 Feb. 2016, Peer-reviewed, Lead author

  

Misc.

• リン脂質スクランブラーゼによる脂質非対称性の変化と生理的な役割

  茂谷 小百合; 鈴木 淳

  医学のあゆみ, Dec. 2023, Lead author

  

Presentations

• ひとつの細胞が持つべき核の数 -細胞融合による破骨細胞多核化メカニズムの解明を目指して-

  茂谷小百合

  2025京大100人論文, 04 Nov. 2025

  
• Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys

  Sayuri Motani; Yukihiro Yabuta; Ken Mizuta; Yoshitaka Katou; Ikuhiro Okamoto; Masanori Kawasaki; Ayaka Kitamura; Tomoyuki Tsukiyama; Chizuru Iwatani; Hideaki Tsuchiya; Taro Tsujimura; Takuya Yamamo; Tomonori Nakamura; Mitinori Saitou

  The 21st Takeda Science Foundation Symposium on Bioscience -- Towards Understanding Human Development and Evolution, Jan. 2023

  
• Mechanism of phospholipid scrambling by TMEM16 family

  Sayuri Gyobu; Shigekazu Nagata

  iCeMS Retreat 2017, Oct. 2017

  
• Mechanism and physiological role of phospholipid scrambling by TMEM16 family

  形部小百合; 長田重一

  The 30th IFReC Colloquium, Apr. 2017

  
• TMEM16ファミリーが有するスクランブリングドメインの機能解析

  形部小百合; 鈴木淳; 長田重一

  第89回 日本生化学大会, Sep. 2016

  
• A role of TMEM16E carrying a scrambling domain in sperm motility

  Sayuri Gyobu

  第557回 微研集談会, Apr. 2016

  
• 膜たんぱく質TMEM16Eの精子の運動性、受精能への関与

  形部小百合; 宮田治彦; 伊川正人; 長田重一

  第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会, Dec. 2015

  
• Analysis of the physiological function of TMEM16E

  Sayuri Gyobu; Jun Suzuki; Shigekazu Nagata

  KYOTO UNIVERSITY Global COE “Center for Frontier Medicine” International Symposium/Retreat 2012, Oct. 2012

  

Books and Other Publications

• Means to an end

  Shigekazu Nagata; Takeshi Imao; Sayuri Gyobu; Hiroaki Koda; Takayuki Suzuki; Satoshi Toda, Joint translation, Green, Douglas R

  Medical Science International, Jun. 2012

  Find Kyoto University's collection of books :

  

External funds: Kakenhi

• Identification of osteoclast cell fusion factor by expression cloning

  Grant-in-Aid for Scientific Research (C)

  Basic Section 44010:Cell biology-related

  Kyoto University

  茂谷 小百合

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  破骨細胞;RAW264;細胞融合;スクリーニング;発現クローニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09453/
• Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys

  Grant-in-Aid for Early-Career Scientists

  Basic Section 48040:Medical biochemistry-related

  Kyoto University

  Sayuri Motani

  From 01 Apr. 2022, To 31 Mar. 2024, Project Closed

  試験管内再構成;ES細胞;卵母細胞;減数分裂;カニクイザル;再構成卵巣;卵母細胞様細胞;第一減数分裂;試験管内誘導;生殖細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K15380/
• Reconstitution of oocyte development from cynomolgus embryonic stem cells in vitro

  Grant-in-Aid for Early-Career Scientists

  Basic Section 42030:Animal life science-related

  Kyoto University

  Sayuri Motani

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  カニクイザル;ES細胞;再構成卵巣;生殖細胞;始原生殖細胞;霊長類モデル;卵子;分化誘導

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16013/