Basic Information

Faculty

• Faculty of Agriculture

Email Address

• Email Address

  uno.kinuko.8skyoto-u.ac.jp

Professional Memberships

• From 2024, To Present

  関西実験動物研究会
• 日本畜産学会
• 日本免疫毒性学会
• 日本毒性病理学会
• 日本毒性学会

Academic Degree

• 20 Mar. 2022

  東京農業大学博士（食品栄養学）
• 20 Mar. 2019

  東京農業大学修士（食品栄養学）

Academic Resume (Undergraduate School/Majors)

• 東京農業大学, 短期大学部栄養学科, 卒業
• 東京農業大学, 応用生物科学部栄養科学科食品栄養学専攻（３年次編入）, 卒業

ID,URL

• J-Global ID

  202301019344479411

• Researcher number

  80980838

researchmap URL

• https://researchmap.jp/yt821tu1212ku81

Research

Research Interests

• モデル動物
• 非アルコール性脂肪性肝炎
• 糖尿病
• CD44

Research Areas

• Life sciences, Gastroenterology

Papers

• High-fat/high-sucrose diet-induced renal changes in obese diabetic mice: a comparison with <i>db/db </i>and KK-Ay mice

  Chika OKI; Kinuko UNO; Tomohiko SASASE; Takahiro TSUTSUI; Keita SEKIGUCHI; Ayane YAMAGUCHI; Kouhei MANDAI; Masami SHINOHARA; Miki SUGIMOTO; Tatsuya MAEKAWA; Katsuhiro MIYAJIMA; Takeshi OHTA

  Journal of Veterinary Medical Science, Dec. 2024, Peer-reviewed

  
• Urinary liver-type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone.

  Keiichi Ohata; Takeshi Sugaya; Hanh Nhung Nguyen; Yuri Hatanaka; Kinuko Uno; Marika Tohma; Tsuyoshi Oikawa; Hiroshi Nagabukuro; Kanako Kuniyeda; Atsuko Kamijo-Ikemori; Noriko Suzuki-Kemuriyama; Dai Nakae; Eisei Noiri; Katsuhiro Miyajima

  Nephrology (Carlton, Vic.), Jun. 2023, Peer-reviewed

  
• Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet. (Lipids in Health and Disease, (2020), 19, 1, (251), 10.1186/s12944-020-01423-3)

  Noriko Suzuki-Kemuriyama; Akari Abe; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae

  Lipids in Health and Disease, Dec. 2022

  
• Pathophysiological Features of Rat Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

  YASUKA SAIGO; KINUKO UNO; TATSUYA ISHIGURE; TATSUMI ODAKE; TAKESHI OHTA

  In Vivo, 30 Apr. 2024, Peer-reviewed

  
• Granulomatous Myocarditis Caused by Candida Spp Infection in a Spontaneously Diabetic Torii Rat

  Kinuko Uno; Soon Teoh; Keita Sekiguchi; Noriko Kemuriyama; Takeshi Ohta; Katsuhiro Miyajima

  Medical Archives, 2024, Peer-reviewed, Lead author

  
• Effects of salt supplementation in uninephrectomized KK-Ay mice: Examining the potential of a diabetic kidney disease model

  Ryuhei Sano; Kanjiro Ryu; Tomohiko Sasase; Yuichi Shinozaki; Soon Hui Teoh; Ayane Yamaguchi; Kinuko Uno; Tatsuya Maekawa; Takeshi Ohta; Katsuhiro Miyajima

  The Journal of Toxicological Sciences, 2023, Peer-reviewed

  
• Urinary liver‐type fatty acid binding protein is a biomarker reflecting renal damage and the ameliorative effect of drugs at an early stage of histone‐induced acute kidney injury

  Keiichi Ohata; Takeshi Sugaya; Hanh Nhung Nguyen; Karin Arai; Yuri Hatanaka; Kinuko Uno; Marika Tohma; Teppei Uechi; Keita Sekiguchi; Tsuyoshi Oikawa; Hiroshi Nagabukuro; Kanako Kuniyeda; Atsuko Kamijo‐Ikemori; Noriko Suzuki‐Kemuriyama; Dai Nakae; Eisei Noiri; Katsuhiro Miyajima

  Nephrology, 11 Nov. 2023, Peer-reviewed

  
• Renal transcriptome analysis of uninephrectomized <i>db/db</i> mice identified a mechanism for the transition to severe diabetic nephropathy

  Mariko MAEKAWA; Tatsuya MAEKAWA; Tomohiko SASASE; Takeshi WAKASHIMA; Atsuhiro UEMURA; Kinuko UNO; Takeshi OHTA; Takahisa YAMADA

  Experimental Animals, Jul. 2023, Peer-reviewed

  
• Choline-deficient Diet-induced NAFLD Animal Model Recaptures Core Human Pathophysiology With Similar gene Co-expression Networks

  Ishigure T; Sasase T; Tohma M; Uno K; Toriniwa Y; Saito T; Saigo Y; Edamura K; Miyajima K; Ohta T

  In Vivo, 2023, Peer-reviewed

  
• Influence of trans-fatty acids on non-alcoholic steatohepatitis with hepatic fibrosis induced by a choline-deficient, methionine-lowered, L-amino acid-defined diet in male Harlan Sprague Dawley rats

  Kinuko Uno; Katsuhiro Miyajima; Marika Matsumoto; Marika Toma; Noriko Suzuki-Kemuriyama; Dai Nakae

  Fundamental Toxicological Sciences, 2021, Peer-reviewed, Lead author

  
• Unilaternal nephrectomized SHR/NDmcr-cp rat shows a progressive decline of glomerular filtration with tubular interstitial lesions

  Shinozaki Y; Fukui K; Maekawa M; Toyoda K; Yoshiuchi H; Inagaki K; Uno K; Miyajima K; Ohta T

  Physiol. Res., 2023, Peer-reviewed

  
• High-cholesterol diet in combination with hydroxypropyl-β-cyclodextrin induced NASH-like disorders in the liver of rats

  Saigo Y; Sasase T; Tohma M; Uno K; Shinozaki Y; Maekawa T; Sano R; Miyajima K; Ohta T

  Physiol. Res., 2023, Peer-reviewed

  
• Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet.

  Kinuko Uno; Katsuhiro Miyajima; Shuji Ogawa; Noriko Suzuki-Kemuriyama; Dai Nakae

  Journal of toxicologic pathology, Jan. 2023, Peer-reviewed

  
• Effects of dietary phosphorus concentration and phosphate salt form on renal tubule function in unilateral nephrectomized rats.

  Kikue Mori; Shin-Ichi Katsumata; Katsuhiro Miyajima; Kinuko Uno; Hiroshi Matsuzaki

  Nutrition and health, 29 Aug. 2022, Peer-reviewed

  
• Salt loading with unilateral nephrectomy accelerates decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease.

  Yuichi Shinozaki; Yuko Katayama; Fuminari Yamaguchi; Tomohisa Suzuki; Kana Watanabe; Kinuko Uno; Takahiro Tsutsui; Miki Sugimoto; Masami Shinohara; Katsuhiro Miyajima; Takeshi Ohta

  Clinical and experimental pharmacology & physiology, Apr. 2022, Peer-reviewed

  Access this paper :

  
• CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet.

  Kinuko Uno; Katsuhiro Miyajima; Marika Toma; Noriko Suzuki-Kemuriyama; Dai Nakae

  Journal of toxicologic pathology, Apr. 2022, Peer-reviewed

  
• Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats.

  Yasuka Saigo; Tomohiko Sasase; Kinuko Uno; Yuichi Shinozaki; Tatsuya Maekawa; Ryuhei Sano; Yasufumi Toriniwa; Katsuhiro Miyajima; Takeshi Ohta

  Journal of pharmacological and toxicological methods, 2022, Peer-reviewed

  Access this paper :

  
• Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.

  Noriko Suzuki-Kemuriyama; Akari Abe; Sae Nakane; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae

  FEBS open bio, Nov. 2021, Peer-reviewed

  
• Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus.

  Soon Hui Teoh; Katsuhiro Miyajima; Yuichi Shinozaki; Masami Shinohara; Keiichi Ohata; François Briand; Rika Morimoto; Yuka Nakamura; Kinuko Uno; Noriko Kemuriyama; Dai Nakae; Takeshi Ohta; Tatsuya Maekawa

  The Journal of toxicological sciences, 2021, Peer-reviewed

  
• A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.

  Noriko Suzuki-Kemuriyama; Akari Abe; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae

  Lipids in health and disease, 14 Dec. 2020, Peer-reviewed

  
• Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure.

  Hikaru Hanyu; Yuki Yokoi; Kiminori Nakamura; Tokiyoshi Ayabe; Keisuke Tanaka; Kinuko Uno; Katsuhiro Miyajima; Yuki Saito; Ken Iwatsuki; Makoto Shimizu; Miki Tadaishi; Kazuo Kobayashi-Hattori

  Toxins, 24 Sep. 2020, Peer-reviewed

  
• Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model.

  Tomoyuki Saito; Yasufumi Toriniwa; Yukihito Ishii; Atsuhiro Uemura; Katsuhiro Miyajima; Kinuko Uno; Yuki Shirai; Dai Nakae; Takeshi Ohta

  Journal of toxicologic pathology, Oct. 2018, Peer-reviewed

  
• Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model.

  Yasufumi Toriniwa; Tomoyuki Saito; Katsuhiro Miyajima; Yukihito Ishii; Kinuko Uno; Tatsuya Maekawa; Tohru Matsui; Shinichi Kume; Takahisa Yamada; Takeshi Ohta

  The Journal of veterinary medical science, 06 Jun. 2018, Peer-reviewed

  

Presentations

• ラット食餌誘発性NASHの 肝線維化病態におけるCD44の寄与

  宇野絹子; 太田毅

  関西実験動物研究会第156回研究会, 20 Dec. 2024

  
• 食餌誘発性NASHモデルラットにおける病態発現の系統差

  宇野絹子; 太田毅; 美谷島克宏

  第74回関西畜産学会大会, 25 Nov. 2024

  
• CDAA食負荷ラットにおける肝線維化とCD44発現変動の解析

  宇野絹子; 美谷島克宏; 太田毅

  日本畜産学会第132回大会, Sep. 2024

  
• CD44 -a novel therapeutic target for NASH-

  Kinuko Uno

  The 6th International Seminar on Smart Molecule of Natural Resources (ISSMART), Aug. 2024, Invited

  
• ラットにおける食餌誘発性非アルコール性脂肪性肝炎様病態の系統差

  宇野絹子; 煙山紀子; 中江大; 太田毅; 美谷島克宏

  第51回日本毒性学会学術年会, 05 Jul. 2024

  
• The histopathological effects of loading Western diets on the liver in obese type 2 diabetes model SDT fatty rats.

  小竹立珠; 宇野絹子; 杉本実紀; 笹瀬智彦; 鳥庭靖文; 山田宜永; 太田毅

  日本毒性病理学会, 23 Jan. 2024

  
• Interaction of dextran sodium sulfate-induced colitis and diet-induced NASH

  Kinuko Uno; Yuri Hatanaka; Noriko Kemuriyama; Dai Nakae; Takeshi Ohta; Katsuhiro Miyajima

  日本毒性病理学会, 23 Jan. 2024

  
• Influence of a high-protein diet on diabetic kidney disease in diabetic model rats

  Kinuko Uno; Kana Watanabe; Tomohiko Sasase; Tatsuya Maekawa; Tatsumi Odake; Masami Shinohara; Chie Shimomura; Katsuhiro Miyajima; Takeshi Ohta

  The 5th International Seminar on Smart Molecule of Natural Resources (ISSMART), Sep. 2023

  
• Pathophysiological analysis of the kidneys in obese type 2 diabetes model db/db mice fed a high-sucrose/high-fat/high-cholesterol diet

  Yushi Ishikawa; Tatsumi Odake; Tomohiko Sasase; Masaaki Handa; Yoshinobu Doi; Masami Shinohara; Kinuko Uno; Miki Sugimoto; Takeshi Ohta

  The 5th International Seminar on Smart Molecule of Natural Resources (ISSMART), Sep. 2023

  
• Influence of high-protein diet on diabetic nephropathy in SDT fatty rats

  Kinuko Uno; Kana Watanabe; Tomohiko Sasase; Tatsuya Maekawa; Tatsumi Odake; Masami Shinohara; Katsuhiro Miyajima; Takeshi Ohta

  IDF-WPR Congress 2023 / 15th Scientific Meeting of the AASD, 21 Jul. 2023

  
• Effects of dextran sulfate sodium- induced colitis on non-alcoholic steatohepatitis in mice

  Kinuko Uno; Karen Nagura; Yuri Hatanaka; Noriko Kemuriyama; Dai Nakae; Takeshi Ohta; Katsuhiro Miyajima

  第50回日本毒性学会, 19 Jun. 2023

  
• Participation of CD44 in Hepatic Fibrosis of Non-alcoholic Steatohepatitis in Rats

  Uno K; Miyajima K; Toma M; Kumuriyama N; Nakae D

  The 38th Annual Meeting of the Japanese Society of Toxicologic Pathology., Jan. 2022

  
• ヒト皮膚由来細胞を用いたカテキンの抗老化作用に関する検討

  宇野絹子; 美谷島克宏; グエン・ハン・ニユン; 中山勉

  第17回日本カテキン学会学術年会, 11 Dec. 2021

  
• ラットの非アルコール性脂肪性肝炎病態の肝線維化におけるCD44の関与

  宇野絹子; 美谷島克宏; 煙山紀子; 中江大

  第28回日本免疫毒性学会学術年会, 2021

  
• SDTfattyラットにおけるACE2発現の検討

  宇野絹子; 美谷島克宏; 石田ゆりか; 山口彩音; 煙山紀子; 中江大

  第48回日本毒性学会学術年会, Jul. 2021

  
• Involvement of the enterohepatic axis in non-alcoholic steatohepatitis (NASH) induced by a choline- deficient, methionine-lowered, amino acid-defined (CDAA)diet in rats

  Uno K; Miyajima K; Kumuriyama N; Nakae D

  The 37th Annual Meeting of the Japanese Society of Toxicologic Patholog, Jan. 2021

  
• CDAA食給餌により誘発したNASH病態の肝線維化亢進におけるTLRシグナルの関与

  宇野絹子; 美谷島克宏; 煙山紀子; 中江大

  第27回日本免疫毒性学会学術年会, Sep. 2020

  
• hL-FABP Tg マウスの肝障害に対する反応性の検討

  宇野絹子; 美谷島克宏; 龍完次朗; 大畑敬一; 煙山紀子; 中江大

  第47回日本毒性学会学術年会, Jun. 2020

  
• Analysis of the toxicity mechanisms on the intestinal injury induced by deoxynivalenol in mice.

  Uno K; Miyajima K; Numata D; Yato R; Kumuriyama N; Nakae D

  The 36th Annual Meeting of the Japanese Society of Toxicologic Pathology, Feb. 2020

  
• Phenotypical and genotypical strain difference on the manifestation of NASH between Hsd and F344 rats fed the CDAA diet

  Uno K; Kumuriyama N; Nakae D

  The 78st Annual Meeting of the Japanese Cancer Association, Sep. 2019

  
• デキストラン硫酸ナトリウム誘発大腸炎モデルマウスにおいてコリン欠乏メチオニン低減アミノ酸食が及ぼす影響

  宇野絹子; 美谷島克宏; 名倉かれん; 高臨風; 龍完次朗; 山口彩音; 小川秀治; 渡邊厚; 煙山紀子; 中江大

  第46回日本毒性学会学術年会, Jun. 2019

  
• Effects of Siraitia Grosvenorii Extract on NASH-like lesions in F344 rats fed a choline-deficient, methionine-lowered, L-amino acid-defined diet.

  Uno K; Miyajima K; Suzuki K; Kikuchi K; Nakai A; Nagayoshi T; Teoh Soon Hui; Kumuriyama N; Koyanagi M; Hayashi S; Ogawa S; Watanabe A; Nakae D

  The 35th Annual Meeting of the Japanese Society of Toxicologic Pathology, Jan. 2019

  
• SD系及びF344系ラットにおけるCDAA食誘発性NASH様病態の系統差

  宇野絹子; 美谷島克宏; 鈴木佳奈恵; 煙山紀子; 中江大

  第34回発癌病理研究会, 2019

  
• SD系及びF344系ラットにおけるＣＤＡＡ食誘発性NASH様病態の系統差と当該病態にトランス脂肪酸が及ぼす影響

  宇野絹子; 美谷島克宏; 煙山紀子; 中江大

  第28回日本健康医学会学術年会, Nov. 2018

  
• Strain difference on the influence of trans fatty acids on NASH induced by the CDAA diet between Hsd and F344 ratas

  Uno K; Kumuriyama N; Nakae D

  The 77st Annual Meeting of the Japanese Cancer Association, Sep. 2018

  
• Zucker fatty/ lean ラットにおけるウェスタンダイエットによる非アルコール性脂肪性肝炎（NASH）様病態の誘発

  宇野絹子; 美谷島克宏; 太田毅; 斎藤友幸; 鳥庭靖文; 張舜恵; 白井雄大; 小川秀治; 渡邊厚; 煙山紀子; 中江大

  第45回日本毒性学会学術年会, Jul. 2018

  
• Zucker fatty ラットにおいてウェスタンダイエットが非アルコール性脂肪性肝炎（NASH）様病態の誘発に及ぼす影響

  宇野絹子; 美谷島克宏; 太田毅; 斎藤友幸; 鳥庭靖文; 張舜恵; 白井雄大; 小川秀治; 渡邊厚; 煙山紀子; 中江大

  第24回日本食品化学学会学術年会, May 2018

  
• Influence of strain difference of trans fatty acids on NASH-like lesions between Hsd rats and F344 rats fed with a choline-deficient, methionine-lowered, amino acid-defined diet.

  Uno K; Miyajima K; Teoh Soon Hui; Kumuriyama N; Ogawa S; Watanabe A; Nakae D

  The 34th Annual Meeting of the Japanese Society of Toxicologic Pathology., Jan. 2018

  
• SD系及びF344系ラットにおけるCDAA食誘発性NASH様病態の系統差と、当該病態にトランス脂肪酸が及ぼす影響

  宇野絹子; 美谷島克宏; 張舜恵; 高臨風; 龍完次朗; 煙山紀子; 中江大

  第33回発癌病理研究会, 2018

  
• ラットにおけるコリン欠乏メチオニン低減アミノ酸食による非アルコール性脂肪性肝炎様病態に対してトランス脂肪酸が及ぼす影響

  宇野絹子; 美谷島克宏; 松本茉里香; 張舜恵; 煙山紀子; 小川秀治; 渡邊厚; 中江大

  第44回日本毒性学会学術年会, Jul. 2017

  

Awards

• 10 Nov. 2018

  湖歩会藤原賞（日本健康医学会）
• 14 Feb. 2020

  食品安全優秀発表賞（San-Ei Gen F.F.I Award）（日本毒性病理学会）

External funds: Kakenhi

• サルコペニア及び糖尿病におけるCD44の病態への寄与の解析

  Grant-in-Aid for Research Activity Start-up

  0909:Sports sciences, physical education, health sciences, and related fields

  Kyoto University

  宇野 絹子

  From 31 Aug. 2023, To 31 Mar. 2025, Granted

  サルコペニア;糖尿病;モデル動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K19923/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Animal Physiology and Anatomy

  DF15, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Animal Physiology and Anatomy

  DF15, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Animal Science I

  5361, Spring, Faculty of Agriculture, 6
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Animal Science II

  5363, Fall, Faculty of Agriculture, 6
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Animal Physiology and Anatomy

  DG15, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Animal Physiology and Anatomy

  DG15, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Animal Pathophysiology

  DA56, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Practical Course in Applied Animal Science II

  1046, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Animal Science

  5699, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Animal Physiology and Anatomy1

  DB34, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Animal Physiology and Anatomy2

  DB35, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Animal Physiology and Anatomy1

  DC34, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Animal Physiology and Anatomy2

  DC35, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Practical Course in Applied Animal Science II

  1046, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Animal Science

  5699, Spring, Faculty of Agriculture, 2