Basic Information

Academic Degree

• (Kyoto University)

Academic Resume (Graduate Schools)

• Kyoto University, 大学院医学研究科博士課程医学専攻, 研究指導認定退学
• Kyoto University, 大学院医学研究科博士課程医学専攻, 修了

High School

• High School

  洛星高等学校

Research History

• From May 2021, To Present

  Kyoto University, Center for iPS Cell Research and Application, Program-specific senior lecturer
• From Apr. 2016, To Apr. 2021

  Kyoto University, Center for iPS Cell Research and Application, Program-specific assistant professor
• From Apr. 2010, To Mar. 2016

  Kyoto University, Center for iPS Cell Research and Application, 特定研究員

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0003-0992-1220

• J-Global ID

  201401073551763400

• Researcher number

  10587851

researchmap URL

• https://researchmap.jp/7000010478

Research

Research Topics, Overview of the research

• Research Topics

  Clinical Application of Stem Cell Therapy for Parkinson's Disease

Research Interests

• 脳卒中
• Cell transplantation therapy
• Parkinson's disease
• Pluripotent stem cells

Research Areas

• Life sciences, Neuroscience - general

Papers

• Transplantation of Human iPS Cell-derived Cerebral Cortical Neurons Promotes Fine Motor Recovery in a Female Mouse Model of Ischemic Stroke

  Hokuto Yamashita; Tetsuhiro Kikuchi; Yusaku Kodaka; Daisuke Doi; Megumi Ikeda; Jun Takahashi

  Stem Cell Reviews and Reports, 11 Oct. 2025

  
• Evaluation of the Computed Tomographic Angiography for the Diagnosis of the Ruptured Cerebral Aneurysm

  Doi Kent; KURAMOTO Yoji; Doi Daisuke; FUNAKI Takeshi; OSHIMOTO Tsuyoshi; YOSHIDA Kazumichi; NARUMI Osamu; CHIN Masaki; YAMAGATA Sen

  Surgery for cerebral stroke, Jul. 2007, Peer-reviewed

  
• Comparison Between Carotid Endarterectomy and Carotid Artery Stenting: Perioperative Outcomes in an Institution

  FUNAKI Takeshi; YOSHIDA Kazumichi; DOI Kent; KURAMOTO Yoji; DOI Daisuke; OSHIMOTO Takeshi; NARUMI Osamu; CHIN Masaki; YAMAGATA Sen; MITSUDO Kazuaki

  Surgery for cerebral stroke, Mar. 2006, Peer-reviewed

  
• 頸動脈閉塞後の自然再開通

  吉田 和道; 土井 健人; 蔵本 要二; 土井 大輔; 舟木 健史; 押本 剛; 鳴海 治; 沈 正樹; 山形 専; 井上 勝美

  脳卒中, Apr. 2005, Peer-reviewed

  
• GH補充療法を開始した2年後にMRIで増大を認めた下垂体柄腫大性病変の一例

  沈 正樹; 土井 健人; 蔵本 要二; 土井 大輔; 舟木 健史; 押本 剛; 吉田 和道; 鳴海 治; 山形 専; 西 有子; 藤原 充弘

  小児の脳神経, Apr. 2005, Peer-reviewed

  
• 急性椎骨脳底動脈閉塞症に対する血管内治療の治療成績,予後の検討

  蔵本 要二; 土井 健人; 押本 剛; 土井 大輔; 舟木 健史; 吉田 和道; 鳴海 治; 沈 正樹; 山形 専

  脳卒中, Apr. 2005, Peer-reviewed

  
• 頸動脈狭窄性病変からのA to A embolismの診断にMRIプラーク評価が有用であった3例

  土井 大輔; 土井 健人; 蔵本 要二; 舟木 健史; 押本 剛; 吉田 和道; 鳴海 治; 沈 正樹; 山形 専

  脳卒中, Apr. 2005, Peer-reviewed

  
• 全前脳胞症に伴う水頭症のシャントトラブルの原因を3D-CT脳室造影にて診断し神経内視鏡的に治療した1例

  押本 剛; 後藤 正憲; 土井 大輔; 舟木 健史; 吉田 和道; 鳴海 治; 沈 正樹; 山形 専

  小児の脳神経, Apr. 2004, Peer-reviewed

  
• Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

  Nobukatsu Sawamoto; Daisuke Doi; Etsuro Nakanishi; Masanori Sawamura; Takayuki Kikuchi; Hodaka Yamakado; Yosuke Taruno; Atsushi Shima; Yasutaka Fushimi; Tomohisa Okada; Tetsuhiro Kikuchi; Asuka Morizane; Satoe Hiramatsu; Takayuki Anazawa; Takero Shindo; Kentaro Ueno; Satoshi Morita; Yoshiki Arakawa; Yuji Nakamoto; Susumu Miyamoto; Ryosuke Takahashi; Jun Takahashi

  Nature, 22 May 2025

  Access this paper :

  
• Cell transplantation therapy using induced pluripotent stem cell-derived dopaminergic progenitors for parkinson’s disease

  Daisuke Doi; Jun Takahashi

  Drug Delivery System, 2020

  
• Viral delivery of L1CAM promotes axonal extensions by embryonic cerebral grafts in mouse brain.

  Ryosuke Tsuchimochi; Keitaro Yamagami; Naoko Kubo; Naoya Amimoto; Fabian Raudzus; Bumpei Samata; Tetsuhiro Kikuchi; Daisuke Doi; Koji Yoshimoto; Aya Mihara; Jun Takahashi

  Stem cell reports, 11 Apr. 2023

  Access this paper :

  
• Cryopreservation of Induced Pluripotent Stem Cell-Derived Dopaminergic Neurospheres for Clinical Application

  Satoe Hiramatsu; Asuka Morizane; Tetsuhiro Kikuchi; Daisuke Doi; Kenji Yoshida; Jun Takahashi

  Journal of Parkinson's Disease, 05 Apr. 2022

  Access this paper :

  
• Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson's disease.

  Daisuke Doi; Hiroaki Magotani; Tetsuhiro Kikuchi; Megumi Ikeda; Satoe Hiramatsu; Kenji Yoshida; Naoki Amano; Masaki Nomura; Masafumi Umekage; Asuka Morizane; Jun Takahashi

  Nature communications, 06 Jul. 2020, Peer-reviewed

  Access this paper :

  
• Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains.

  Tetsuhiro Kikuchi; Asuka Morizane; Daisuke Doi; Keisuke Okita; Masato Nakagawa; Hodaka Yamakado; Haruhisa Inoue; Ryosuke Takahashi; Jun Takahashi

  Journal of neuroscience research, Sep. 2017, Peer-reviewed

  
• MHC matching improves engraftment of iPSC-derived neurons in non-human primates.

  Asuka Morizane; Tetsuhiro Kikuchi; Takuya Hayashi; Hiroshi Mizuma; Sayuki Takara; Hisashi Doi; Aya Mawatari; Matthew F Glasser; Takashi Shiina; Hirohito Ishigaki; Yasushi Itoh; Keisuke Okita; Emi Yamasaki; Daisuke Doi; Hirotaka Onoe; Kazumasa Ogasawara; Shinya Yamanaka; Jun Takahashi

  Nature communications, 30 Aug. 2017, Peer-reviewed

  Access this paper :

  
• Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.

  Tetsuhiro Kikuchi; Asuka Morizane; Daisuke Doi; Hiroaki Magotani; Hirotaka Onoe; Takuya Hayashi; Hiroshi Mizuma; Sayuki Takara; Ryosuke Takahashi; Haruhisa Inoue; Satoshi Morita; Michio Yamamoto; Keisuke Okita; Masato Nakagawa; Malin Parmar; Jun Takahashi

  Nature, 30 Aug. 2017, Peer-reviewed

  
• Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1.

  Bumpei Samata; Daisuke Doi; Kaneyasu Nishimura; Tetsuhiro Kikuchi; Akira Watanabe; Yoshimasa Sakamoto; Jungo Kakuta; Yuichi Ono; Jun Takahashi

  Nature communications, 14 Oct. 2016, Peer-reviewed

  Access this paper :

  
• Fail-Safe Therapy by Gamma-Ray Irradiation Against Tumor Formation by Human-Induced Pluripotent Stem Cell-Derived Neural Progenitors.

  Mitsuko Katsukawa; Yusuke Nakajima; Akiko Fukumoto; Daisuke Doi; Jun Takahashi

  Stem cells and development, 01 Jun. 2016, Peer-reviewed

  
• Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1.

  Kaneyasu Nishimura; Daisuke Doi; Bumpei Samata; Shigeo Murayama; Tsuyoshi Tahara; Hirotaka Onoe; Jun Takahashi

  Stem cell reports, 12 Apr. 2016, Peer-reviewed

  Access this paper :

  
• 霊長類モデルへのヒトiPS細胞由来ドパミン神経前駆細胞移植

  菊地哲広; 森実飛鳥; 土井大輔; 井上治久; 高橋良輔; 沖田圭介; 中川誠人; 高良沙幸; 水間広; 尾上浩隆; 林拓也; 高橋淳

  再生医療, 01 Feb. 2016

  
• パーキンソン病患者由来iPSCからのドパミン神経誘導

  菊地哲広; 森実飛鳥; 土井大輔; 井上治久; 高橋良輔; 沖田圭介; 中川誠人; 高橋淳

  再生医療, 01 Feb. 2015

  
• iPS細胞にとっての組織適合性 iPS細胞を用いた脳内細胞移植治療における免疫原性の検討

  森実 飛鳥; 土井 大輔; 菊地 哲広; 沖田 圭介; 水間 広; 尾上 浩隆; 林 拓也; 椎名 隆; 小笠原 一誠; 山中 伸弥; 高橋 淳

  MHC: Major Histocompatibility Complex, Apr. 2014

  
• Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation.

  Daisuke Doi; Bumpei Samata; Mitsuko Katsukawa; Tetsuhiro Kikuchi; Asuka Morizane; Yuichi Ono; Kiyotoshi Sekiguchi; Masato Nakagawa; Malin Parmar; Jun Takahashi

  Stem cell reports, 11 Mar. 2014, Peer-reviewed

  
• A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells.

  Masato Nakagawa; Yukimasa Taniguchi; Sho Senda; Nanako Takizawa; Tomoko Ichisaka; Kanako Asano; Asuka Morizane; Daisuke Doi; Jun Takahashi; Masatoshi Nishizawa; Yoshinori Yoshida; Taro Toyoda; Kenji Osafune; Kiyotoshi Sekiguchi; Shinya Yamanaka

  Scientific reports, 08 Jan. 2014, Peer-reviewed

  Access this paper :

  
• Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primate.

  Asuka Morizane; Daisuke Doi; Tetsuhiro Kikuchi; Keisuke Okita; Akitsu Hotta; Toshiyuki Kawasaki; Takuya Hayashi; Hirotaka Onoe; Takashi Shiina; Shinya Yamanaka; Jun Takahashi

  Stem cell reports, 2013, Peer-reviewed

  
• Neural induction with a dopaminergic phenotype from human pluripotent stem cells through a feeder-free floating aggregation culture.

  Asuka Morizane; Daisuke Doi; Jun Takahashi

  Methods in molecular biology (Clifton, N.J.), 2013, Peer-reviewed

  
• Functional recovery of the murine brain ischemia model using human induced pluripotent stem cell-derived telencephalic progenitors.

  Masanori Gomi; Yasushi Takagi; Asuka Morizane; Daisuke Doi; Masaki Nishimura; Susumu Miyamoto; Jun Takahashi

  Brain research, 12 Jun. 2012, Peer-reviewed

  
• Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's disease.

  Daisuke Doi; Asuka Morizane; Tetsuhiro Kikuchi; Hirotaka Onoe; Takuya Hayashi; Toshiyuki Kawasaki; Makoto Motono; Yoshiki Sasai; Hidemoto Saiki; Masanori Gomi; Tatsuya Yoshikawa; Hideki Hayashi; Mizuya Shinoyama; Mohamed M Refaat; Hirofumi Suemori; Susumu Miyamoto; Jun Takahashi

  Stem cells (Dayton, Ohio), May 2012, Peer-reviewed

  
• Cytotoxic T lymphocyte antigen 4 immunogloblin promotes neuronal differentiation in the grafts of embryonic stem cell-derived neural precursor cells

  M. Shinoyama; M. Ideguchi; H. Hayashi; D. Doi; N. Hashimoto; M. Suzuki; J. Takahashi

  Neuroscience, 27 Jan. 2012, Peer-reviewed

  
• 神経再生の最前線 パーキンソン病に対するES、iPS細胞移植治療の開発

  高橋 淳; 土井 大輔; 森実 飛鳥; 尾上 浩隆; 林 拓也; 川崎 俊之

  神経組織の成長・再生・移植研究会学術集会プログラム・予稿集, Jun. 2011, Peer-reviewed

  
• Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells.

  Asuka Morizane; Daisuke Doi; Tetsuhiro Kikuchi; Kaneyasu Nishimura; Jun Takahashi

  Journal of neuroscience research, Feb. 2011, Peer-reviewed

  
• Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease.

  Tetsuhiro Kikuchi; Asuka Morizane; Daisuke Doi; Hirotaka Onoe; Takuya Hayashi; Toshiyuki Kawasaki; Hidemoto Saiki; Susumu Miyamoto; Jun Takahashi

  Journal of Parkinson's disease, 2011, Peer-reviewed

  
• Differences in neural differentiation propensity among cell lines of human \npluripotent stem cells

  Morizane A; Doi D; Kikuchi T; Takahashi J

  Neuroscience 2010（2010.11.14, San Diego, California）, 14 Nov. 2010, Peer-reviewed

  
• Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors

  Masaomi Koyanagi; Jun Takahashi; Yoshiki Arakawa; Daisuke Doi; Hitoshi Fukuda; Hideki Hayashi; Shuh Narumiya; Nobuo Hashimoto

  Journal of Neuroscience Research, 01 Feb. 2008, Peer-reviewed

  
• Brain metastasis of hepatocellular carcinoma after living-donor liver transplantation: A case report

  Daisuke Doi; Ken-Ichiro Kikuta; Hiroto Egawa; Shinji Uemoto; Nobuo Hashimoto

  Japanese Journal of Neurosurgery, 2006, Peer-reviewed

  
• Surgical clipping of a recurrent small saccular aneurysm after repeated coil embolization: Case report

  Kazumichi Yoshida; Takafumi Wataya; Masato Hojo; Daisuke Doi; Sen Yamagata

  Neurologia Medico-Chirurgica, Jul. 2005, Peer-reviewed

  

Misc.

• Assessment of Tissue Viability by Apparent Diffusion Coefficient in Acute Human Stroke

  FUNAKI Takeshi; KURAMOTO Youji; GOTO Masanori; OSHIMOTO Takeshi; DOI Daisuke; YOSHIDA Kazumichi; NARUMI Osamu; CHIN Masaki; YAMAGATA Sen; Takeshi FUNAKI; Youji KURAMOTO; Masanori GOTO; Takeshi OSHIMOTO; Daisuke DOI; Kazumichi YOSHIDA; Osamu NARUMI; Masaki CHIN; Sen YAMAGATA; Dapartment of Neurosurgery Kurashiki Central Hospital; Dapartment of Neurosurgery Kurashiki Central Hospital; Dapartment of Neurosurgery Kurashiki Central Hospital; Dapartment of Neurosurgery Kurashiki Central Hospital; Dapartment of Neurosurgery Kurashiki Central Hospital; Dapartment of Neurosurgery Kurashiki Central Hospital; Dapartment of Neurosurgery Kurashiki Central Hospital; Dapartment of Neurosurgery Kurashiki Central Hospital; Dapartment of Neurosurgery Kurashiki Central Hospital

  脳卒中の外科 = Surgery for cerebral stroke, 31 Jan. 2005

  
• Regenerative medicine for Parkinson's disease: the present and the future perspectives

  土井 大輔; 高橋 淳

  総合リハビリテ-ション, Jan. 2011

  
• iPSC-derived cell therapy for Parkinson's disease

  土井 大輔; 高橋 淳

  生体の科学, Jul. 2016

  
• 霊長類モデルを用いたパーキンソン病に対する細胞移植治療の非臨床試験

  菊地哲広; 森実飛鳥; 土井大輔; 孫谷弘明; 高橋良輔; 井上治久; 井上治久; 沖田圭介; 中川誠人; 高橋淳

  日本再生医療学会総会(Web), 2018

  
• 霊長類パーキンソン病モデルへのヒトiPS細胞由来ドパミン神経前駆細胞移植

  菊地哲広; 森實飛鳥; 土井大輔; 井上治久; 高橋良輔; 沖田圭介; 中川誠人; 高橋淳

  再生医療, 01 Feb. 2017

  
• 神経難病と再生医療 (特集 難病対策)

  土井 大輔; 髙橋 淳

  公衆衛生, Jun. 2016

  
• カニクイザルiPS細胞を用いた脳内神経細胞同種移植

  森実飛鳥; 土井大輔; 菊地哲広; 沖田圭介; 高良沙幸; 水間広; 尾上浩隆; 林拓也; 椎名隆; 石垣宏仁; 小笠原一誠; 高橋淳; 高橋淳

  再生医療, 01 Feb. 2016

  
• Autologous or HLA-matched cell transplantation for Parkinson’s disease with induced pluripotent stem cells

  Morizane A; Doi D; Kikuchi T; Okita K; Mizuma H; Takara, S; Onoe H; Hayashi T; Shiina T; Ogasawara K; Yamanaka S; Takahashi J

  ISSCR Annual Meeting 2015, Jun. 2015, Peer-reviewed

  
• Induced pluripotent stem cells derived from idiopathic parkinson’s disease patients differentiate into midbrain dopaminergic neurons and improve motor function of parkinson’s disease model rats

  Keisuke OkitaKikuchi T; Morizane A; Doi D; Okita K; Nakagawa M; Inoue H; Takahashi R; Takahashi J

  ISSCR Annual Meeting 2015, Jun. 2015, Peer-reviewed

  
• カニクイザルiPS細胞由来ドパミン神経を用いた同種MHC適合移植

  MORIZANE ASUKA; DOI DAISUKE; KIKUCHI TETSUHIRO; OKITA KEISUKE; TAKARA SAYUKI; MIZUMA HIROSHI; ONOE HIROTAKA; HAYASHI TAKUYA; SHIINA TAKASHI; ISHIGAKI KOJI; OGASAWARA KAZUMASA; YAMANAKA SHIN'YA; TAKAHASHI JUN

  再生医療, 01 Feb. 2015

  
• iPS細胞モデルによるLRRK2 12020T変異パーキンソン病の研究

  小芝 泰; 森實 飛鳥; 菊地 哲弘; 山門 穂高; 陣上 直人; 土井 大輔; 西村 周泰; 皆川 栄子; 江川 斉宏; 井上 治久; 高橋 淳; 高橋 良輔

  臨床神経学, Dec. 2014

  
• パーキンソン病のVisual View パーキンソン病とiPS細胞技術

  土井 大輔; 髙橋 淳

  Frontiers in Parkinson disease, May 2014

  
• iPS細胞を用いた脳内細胞移植治療における免疫原性の検討

  MORIZANE ASUKA; DOI DAISUKE; KIKUCHI TETSUHIRO; OKITA KEISUKE; MIZUMA HIROSHI; ONOE HIROTAKA; HAYASHI TAKUYA; SHIINA TAKASHI; OGASAWARA KAZUMASA; YAMANAKA SHIN'YA; TAKAHASHI JUN

  MHC (Web), 20 Apr. 2014

  
• iPS細胞由来ドパミン神経移植の臨床応用へのストラテジー~自家移植およびHLA適合移植の可能性~

  MORIZANE ASUKA; DOI DAISUKE; KIKUCHI TETSUHIRO; OKITA KEISUKE; MIZUMA HIROSHI; ONOE HIROTAKA; HAYASHI TAKUYA; SHIINA TAKASHI; OGASAWARA KAZUMASA; YAMANAKA SHIN'YA; TAKAHASHI JUN

  再生医療, 27 Jan. 2014

  
• パーキンソン病患者由来iPSCからのドパミン神経誘導

  菊地哲広; 森実飛鳥; 土井大輔; 井上治久; 高橋良輔; 沖田圭介; 中川誠人; 高橋淳

  再生医療, 27 Jan. 2014

  
• 疾患特異的iPS細胞モデルによる遺伝性パーキンソン病の研究

  小芝 泰; 森實 飛鳥; 山門 穂高; 菊地 哲宏; 皆川 栄子; 土井 大輔; 西村 周泰; 江川 斉宏; 井上 治久; 高橋 淳; 高橋 良輔

  臨床神経学, Dec. 2013

  
• Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Neurons Causes Minimum Immune Reaction in the Brain of Non-Human Primate

  Morizane, A; Doi, D; Kikuchi, T; Okita, K; Hotta, A; Kawasaki, T; Onoe, H; Shiina, T; Takahashi, J

  ISSCR 11th Annual Meeting, Jun. 2013, Peer-reviewed

  
• ｉPS細胞を用いた自家移植の有効性 ～カニクイザル脳内神経細胞移植の系を用いて～

  森実飛鳥; 土井大輔; 菊地哲広; 沖田圭介; 川崎俊之; 尾上浩隆; 田中景子; 椎名 隆; 高橋 淳

  第12回日本再生医療学会総会, Mar. 2013

  
• パーキンソン病患者由来iPSCからのドパミン神経誘導

  菊地哲広; 森実飛鳥; 土井大輔; 井上治久; 沖田圭介; 高橋淳

  再生医療, 28 Feb. 2013

  
• Differentiation from primate induced pluripotent stem cells designed for an auto-grafting model system.

  Morizane A; Okita K; Doi D; Kikuchi T; Takahashi J

  ISSCR 10th annual Meeting, Jun. 2012, Peer-reviewed

  
• サルiPS細胞による神経分化誘導:自家移植モデルを目指して

  森実飛鳥; 沖田圭介; 土井大輔; 菊地哲広; 高橋淳

  再生医療, 16 May 2012

  
• パーキンソン病患者由来iPSCからのドーパミン神経誘導

  菊地哲広; 森実飛鳥; 土井大輔; 井上治久; 沖田圭介; 高橋淳

  再生医療, 16 May 2012

  
• 霊長類パーキンソン病モデルにおけるヒトES 細胞由来神経細胞の腫瘍源性と機能

  土井大輔; 森実飛鳥; 高橋淳

  第15 回日本異種移植研究会（2012.12.8．京都）, 2012, Peer-reviewed

  
• 臨床応用のためのヒト多能性幹細胞由来のドーパミン神経細胞純化方法の検討

  土井大輔; 菊地哲広; 森実飛鳥; 高橋淳

  第11 回日本再生医療学会総会（2012.06.12．横浜）, 2012, Peer-reviewed

  
• 幹細胞から分化誘導した中脳ドーパミン神経細胞の濃縮

  佐俣文平; 土井大輔; 尾野雄一; 高橋淳

  第10 回日本再生医療学会総会（2011.3.1 東京）, 2011, Peer-reviewed

  
• ヒトES 細胞を用いたカニクイザルパーキンソ ン病モデルへの細胞移植

  森実飛鳥; 土井大輔; 菊地哲広; 吉川達也; 五味正憲; 高橋 淳

  第10 回 日本再生医療学会総会（2011.03.01 東京）, 2011, Peer-reviewed

  
• カニクイザルパーキンソン病 モデルへの ヒトES細胞由来ドーパミン神経細胞の移植 Transplantation of stem cell-derived dopaminergic neurons in primate brains

  森実飛鳥; 土井大輔; 菊地哲広; 吉川達也; 尾上浩隆; 林 拓也; 川崎俊之; 高橋 淳

  第70 回日本脳神経外科学会総会（2011.10.12 横浜）, 2011, Peer-reviewed

  
• 分子化合物を用いたヒト多能性幹細胞からの神経誘導

  森実飛鳥; 土井大輔; 菊地哲広; 高橋淳

  第9 回日本再 生医療学会総会（2010.3.18 広島）, 2010, Peer-reviewed

  
• ヒトES 細胞由来の神経細胞移植における霊長類パーキンソン病モデルでの腫瘍形成

  土井大輔; 菊地哲広; 森実飛鳥; 高橋淳

  第4 回パーキンソン病・運動障害疾患コングレス（2010.10.8 京都）, 2010, Peer-reviewed

  
• 霊長類パーキンソン病モデルに対するヒトES 細胞由来移 植片の腫瘍源性

  土井大輔; 菊地哲広; 森実飛鳥; 斎木英資; 高橋淳

  第9 回日本再生医療学会総会（2010.3.18－19 広島）, 2010, Peer-reviewed

  
• サルiPS 細胞からのドーパミン神経分化誘導

  森実飛鳥; 菊地哲広; 吉川達也; 土井大輔; 高橋淳

  神経組織の成長・再生・移植研究会第25 回学術集会（2010.5.22 大阪）, 2010, Peer-reviewed

  
• パーキンソン病モデルサルに対するヒトiPS 細胞由来ドーパミン神経移植

  菊地哲広; 森実飛鳥; 土井大輔; 尾上浩隆; 林拓也; 川崎俊之; 宮本享; 高橋淳

  社団法人日本脳神経外科学会第69 回学術総会 （2010.10.27－29．福岡）, 2010, Peer-reviewed

  
• Optimization of the protocol and cell line selection are important for generation of dopamine neurons from human induced pluripotent stem（iPS）cells.

  Morizane A; Doi D; Kikuchi T; Takahashi J

  NeuroStemcell Workshop （2010.9.25 Mallorca, Spain）, 2010, Peer-reviewed

  
• Tumor formation in cell replacement therapy using human ES cells

  Jun Takahashi; Daisuke Doi; Asuka Morizane

  NEUROSCIENCE RESEARCH, 2009

  
• 浮遊培養法によるヒトiPS細胞からの神経分化誘導

  菊地哲広; 森実飛鳥; 土井大輔; 宮本享; 高橋淳

  日本脳神経外科学会第68 回学術総会（2009.10.14－16．東京）, 2009, Peer-reviewed

  
• ヒトES 細胞由来の神経細胞移植における腫瘍形成とその回避

  土井大輔; 菊地哲広; 林英樹; 森実飛鳥; 宮本享; 高橋淳

  日本脳神経外科学会（2009.10.14．東京）, 2009, Peer-reviewed

  
• ヒト多能性幹細胞からの神経誘導におけるNodal/BMP抑制の役割

  森実飛鳥; 土井大輔; 菊地哲広; 宮本享; 高橋淳

  第68回日本脳神経外科学会学術総会（2009.10.14－17．東京）, 2009, Peer-reviewed

  
• Wnt シグナルを利用したES 細胞からの神経誘導法の開発

  林英樹; 土井大輔; 高橋淳

  第67回日本脳神経 外科学会（2008.10.1-3．盛岡）, 2008, Peer-reviewed

  

External funds: Kakenhi

• iPS細胞由来大脳皮質オルガノイド移植とリハビリテーションの相乗効果の検討

  Grant-in-Aid for Scientific Research (C)

  Basic Section 59010:Rehabilitation science-related

  Kyoto University

  土井 大輔

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  大脳皮質神経細胞製剤;脳梗塞;細胞移植治療;リハビリテーション;大脳皮質細胞製剤;脳血管障害

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K11416/
• Rewiring the brain: remote-controlled axon guidance by magnetic nanoparticles to improve Parkinson's therapies

  Grant-in-Aid for Scientific Research (C)

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  Raudzus Fabian

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  Parkinson's Disease;Magnetic Nanoparticle;Cell Replacment;Stem Cells;Dopaminergic Neurons;Dopaminergic neurons;Stem cells (iPSCs);Magnetic nanoparticles;Halbach magnet;Axon guidance;CNS regeneration;Parkinson's disease;Nanotechnology;Cell Replacement Therapy;Magnetic Nanoparticles;Pluripotent Stem Cells;Neuronal Regeneration

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06430/
• Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56010:Neurosurgery-related

  Kyoto University

  荒川 芳輝

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  グリオーマ;正常脳;IDH変異型クローン;先制医療;3次元的網羅的ゲノム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03186/
• Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56010:Neurosurgery-related

  Kyoto University

  荒川 芳輝

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  グリオーマ;正常脳;IDH変異型クローン;先制医療;3次元的網羅的ゲノム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24445/
• 脳梗塞に対するiPS細胞由来大脳オルガノイド移植とProgranulin遺伝子治療の相乗効果

  Grant-in-Aid for Scientific Research (C)

  Basic Section 56010:Neurosurgery-related

  Kyoto University

  土井 大輔

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  脳オルガノイド;脳梗塞;細胞移植治療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K12385/

Administration

Faculty management (title, position)

• From 01 Apr. 2020, To 31 Mar. 2026

  動物実験委員会
• From 01 Apr. 2021, To 31 Mar. 2027

  化学物質管理委員会