Basic Information

Professional Memberships

• To Present

  日本動脈硬化学会
• To Present

  日本循環器学会
• To Present

  日本内科学会

Academic Degree

• 博士（医学）(京都大学)

Research History

• From Sep. 2019, To Present

  Kyoto University, Hospital, 特定講師
• From Jul. 2016, To Aug. 2019

  Washington University School of Medicine in St. Louis, Department of Pathology and Immunology, Postdoctoral Associate
• From Apr. 2015, To Jun. 2016

  Kyoto University, Hospital, 医員
• From Apr. 2014, To Mar. 2015

  Kyoto University, Faculty of Medicine, 研修員
• From Apr. 2006, To Mar. 2010

  市立岸和田市民病院, 循環器内科, 医師
• From Jun. 2004, To Mar. 2006

  市立岸和田市民病院, 内科, 研修医
• From May 2003, To May 2004

  Kyoto University, Hospital, 研修医

ID,URL

• J-Global ID

  201901015496425696

• Researcher number

  30758446

researchmap URL

• https://researchmap.jp/o.baba

Research

Research Interests

• ケモカイン受容体
• マクロファージ
• PET
• 動脈硬化

Research Areas

• Life sciences, Cardiology

Papers

• Serum HDL Cholesterol Decreases in Microrna-33b Knock-in Mice for an Intron of Sterol Regulatory Element-binding Factor 1 (Srebf1)

  Hone Takahiro; Nishino Tomohiro; Baba Osamu; Kuwabara Yasuhide; Nakao Tetsushi; Nishiga Masataka; Usami Shunsuke; Izuhara Masayasu; Nakazeki Fumiko; Ide Yuya; Koyama Satoshi; Sowa Naoya; Nakashima Yasuhiro; Hakuno Daihiko; Kimura Takeshi; Ono Koh

  CIRCULATION, 10 Nov. 2015, Peer-reviewed

  
• Serum HDL-C Decreases in MicroRNA-33b Knock-in Mice for an Intron of Sterol Regulatory Element-binding Factor 1 (Srebf1)

  Horie Takahiro; Nishino Tomohiro; Kuwabara Yasuhide; Baba Osamu; Kimura Takeshi; Ono Koh

  CIRCULATION RESEARCH, 17 Jul. 2015, Peer-reviewed

  
• Microrna-33, Located Within Srebf2 Intron, Regulate Fatty Acid Synthesis via Targeting SREBP-1 in vivo

  Nishino Tomohiro; Hone Takahiro; Baba Osamu; Kuwabara Yasuhide; Nakao Tetsushi; Nishiga Masataka; Usami Shunsuke; Izuhara Masayasu; Ide Yuya; Nakazeki Fumiko; Koyama Satoshi; Yokode Masayuki; Kita Toru; Kimura Takeshi; Ono Koh

  CIRCULATION, 25 Nov. 2014, Peer-reviewed

  
• LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Ventricular Cardiomyocytes

  Kuwabara Yasuhide; Izuhara Masayasu; Horie Takahiro; Watanabe Shin; Baba Osamu; Usami Shunsuke; Nakao Tetsushi; Nishiga Masataka; Nishino Tomohiro; Kita Toru; Kimura Takeshi; Ono Koh

  CIRCULATION, 26 Nov. 2013, Peer-reviewed

  
• Human iPSC-Derived Myocyte Mmodel of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting From Enhanced Protein Degradation

  Hayano Mamoru; Makiyama Takeru; Kamakura Tsukasa; Watanabe Hiroshi; Sasaki Kenichi; Funakoshi Shunsuke; Wuriyanghai Yimin; Nishiuchi Suguru; Harita Takeshi; Yamamoto Yuta; Kohjitani Hirohiko; Hirose Sayako; Yokoi Fumika; Chen Jiarong; Baba Osamu; Horie Takahiro; Chonabayashi Kazuhisa; Ohno Seiko; Toyoda Futoshi; Yoshida Yoshinori; Ono Koh; Horie Minoru; Kimura Takeshi

  CIRCULATION, 14 Nov. 2017, Peer-reviewed

  
• Auxiliary roles of nardilysin in the early diagnosis of acute coronary syndrome: a prospective cohort study, the Nardi-ACS study.

  Mikiko Ohno; Hiroki Shiomi; Osamu Baba; Mariko Yano; Takanori Aizawa; Yukiko Nakano-Matsumura; Shintaro Yamagami; Masashi Kato; Masanobu Ohya; Po-Min Chen; Kazuya Nagao; Kenji Ando; Takafumi Yokomatsu; Kazushige Kadota; Ichiro Kouchi; Tsukasa Inada; Cindy Valentine; Takahiro Kitagawa; Masato Kurokawa; Shigeru Ohtsuru; Takeshi Morimoto; Takeshi Kimura; Eiichiro Nishi

  Internal and emergency medicine, Apr. 2024, Peer-reviewed

  
• KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels

  Shuhei Tsuji; Chiharu Otani; Takahiro Horie; Shin Watanabe; Osamu Baba; Naoya Sowa; Yuya Ide; Asami Kashiwa; Takeru Makiyama; Hirohiko Imai; Yasuhiro Nakashima; Tomohiro Yamasaki; Sijia Xu; Kazuki Matsushita; Keita Suzuki; Fuquan Zou; Eitaro Kume; Koji Hasegawa; Takeshi Kimura; Akira Kakizuka; Koh Ono

  Biomedicine & Pharmacotherapy, Jan. 2024, Peer-reviewed

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• CRISPR-Cas9-guided amplification-free genomic diagnosis for familial hypercholesterolemia using nanopore sequencing.

  Sijia Xu; Hiroki Shiomi; Yugo Yamashita; Satoshi Koyama; Takahiro Horie; Osamu Baba; Masahiro Kimura; Yasuhiro Nakashima; Naoya Sowa; Koji Hasegawa; Ayako Suzuki; Yutaka Suzuki; Takeshi Kimura; Koh Ono

  PloS one, 2024, Peer-reviewed

  
• Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis.

  Sawa Miyagawa; Takahiro Horie; Tomohiro Nishino; Satoshi Koyama; Toshimitsu Watanabe; Osamu Baba; Tomohiro Yamasaki; Naoya Sowa; Chiharu Otani; Kazuki Matsushita; Hidenori Kojima; Masahiro Kimura; Yasuhiro Nakashima; Satoshi Obika; Yuuya Kasahara; Jun Kotera; Kozo Oka; Ryo Fujita; Takashi Sasaki; Akihiro Takemiya; Koji Hasegawa; Takeshi Kimura; Koh Ono

  Life science alliance, Aug. 2023, Peer-reviewed

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• is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.

  Fumiko Nakazeki; Itaru Tsuge; Takahiro Horie; Keiko Imamura; Kayoko Tsukita; Akitsu Hotta; Osamu Baba; Yasuhide Kuwabara; Tomohiro Nishino; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Shuhei Tsuji; Motoko Naitoh; Shigehiko Suzuki; Yuishin Izumi; Toshitaka Kawarai; Ryuji Kaji; Takeshi Kimura; Haruhisa Inoue; Koh Ono

  Clinical Science, 22 Feb. 2019, Peer-reviewed

  
• Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways

  Tomohiro Yamasaki; Takahiro Horie; Satoshi Koyama; Tetsushi Nakao; Osamu Baba; Masahiro Kimura; Naoya Sowa; Kazuhisa Sakamoto; Kazuhiro Yamazaki; Satoshi Obika; Yuuya Kasahara; Jun Kotera; Kozo Oka; Ryo Fujita; Takashi Sasaki; Akihiro Takemiya; Koji Hasegawa; Kenji Minatoya; Takeshi Kimura; Koh Ono

  Scientific Reports, Dec. 2022, Peer-reviewed

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• Overview of the 84th Annual Scientific Meeting of the Japanese Circulation Society - Change Practice!

  Koh Ono; Satoshi Shizuta; Erika Yamamoto; Naritatsu Saito; Neiko Ozasa; Takao Kato; Eri Kato; Takahiro Horie; Junichi Tazaki; Hiroki Shiomi; Shin Watanabe; Hirotoshi Watanabe; Yugo Yamashita; Yusuke Yoshikawa; Hideyuki Kinoshita; Takeru Makiyama; Yoshinori Yoshida; Noboru Ashida; Yasuaki Nakagawa; Yasuhiro Nakashima; Osamu Baba; Hirohiko Kohjitani; Masahiro Kimura; Hideaki Inazumi; Takashi Yoshizawa; Akihiro Komasa; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 25 Feb. 2021

  
• microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.

  Takahiro Horie; Tetsushi Nakao; Yui Miyasaka; Tomohiro Nishino; Shigenobu Matsumura; Fumiko Nakazeki; Yuya Ide; Masahiro Kimura; Shuhei Tsuji; Randolph Ruiz Rodriguez; Toshimitsu Watanabe; Tomohiro Yamasaki; Sijia Xu; Chiharu Otani; Sawa Miyagawa; Kazuki Matsushita; Naoya Sowa; Aoi Omori; Jin Tanaka; Chika Nishimura; Masataka Nishiga; Yasuhide Kuwabara; Osamu Baba; Shin Watanabe; Hitoo Nishi; Yasuhiro Nakashima; Marina R Picciotto; Haruhisa Inoue; Dai Watanabe; Kazuhiro Nakamura; Tsutomu Sasaki; Takeshi Kimura; Koh Ono

  Nature communications, 16 Feb. 2021, Peer-reviewed

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• CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis.

  Osamu Baba; Li-Hao Huang; Andrew Elvington; Martyna Szpakowska; Deborah Sultan; Gyu Seong Heo; Xiaohui Zhang; Hannah Luehmann; Lisa Detering; Andy Chevigne; Yongjian Liu; Gwendalyn J Randolph

  Arteriosclerosis, thrombosis, and vascular biology, Feb. 2021, Peer-reviewed, Lead author

  
• Functional non-coding RNAs in vascular diseases.

  Koh Ono; Takahiro Horie; Osamu Baba; Masahiro Kimura; Shuhei Tsuji; Randolph Ruiz Rodriguez; Sawa Miyagawa; Takeshi Kimura

  The FEBS journal, 19 Dec. 2020, Peer-reviewed

  
• Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload.

  Yasuhide Kuwabara; Shuhei Tsuji; Masataka Nishiga; Masayasu Izuhara; Shinji Ito; Kazuya Nagao; Takahiro Horie; Shin Watanabe; Satoshi Koyama; Hisanori Kiryu; Yasuhiro Nakashima; Osamu Baba; Tetsushi Nakao; Tomohiro Nishino; Naoya Sowa; Yui Miyasaka; Takeshi Hatani; Yuya Ide; Fumiko Nakazeki; Masahiro Kimura; Yoshinori Yoshida; Tsukasa Inada; Takeshi Kimura; Koh Ono

  Communications biology, 13 Aug. 2020, Peer-reviewed

  
• Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity.

  Masahiro Kimura; Takahiro Horie; Osamu Baba; Yuya Ide; Shuhei Tsuji; Randolph Ruiz Rodriguez; Toshimitsu Watanabe; Tomohiro Yamasaki; Chiharu Otani; Sijia Xu; Yui Miyasaka; Yasuhiro Nakashima; Takeshi Kimura; Koh Ono

  EMBO reports, 03 Apr. 2020, Peer-reviewed

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• Identification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice.

  Satoshi Koyama; Takahiro Horie; Tomohiro Nishino; Osamu Baba; Naoya Sowa; Yui Miyasaka; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Fumiko Nakazeki; Yuya Ide; Masahiro Kimura; Shuhei Tsuji; Randolph Ruiz Rodriguez; Sijia Xu; Tomohiro Yamasaki; Chiharu Otani; Toshimitsu Watanabe; Tomoyuki Nakamura; Koji Hasegawa; Takeshi Kimura; Koh Ono

  Journal of the American Heart Association, 02 Jul. 2019, Peer-reviewed

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• MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.

  Fumiko Nakazeki; Itaru Tsuge; Takahiro Horie; Keiko Imamura; Kayoko Tsukita; Akitsu Hotta; Osamu Baba; Yasuhide Kuwabara; Tomohiro Nishino; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Shuhei Tsuji; Motoko Naitoh; Shigehiko Suzuki; Yuishin Izumi; Toshitaka Kawarai; Ryuji Kaji; Takeshi Kimura; Haruhisa Inoue; Koh Ono

  Clinical science (London, England : 1979), 28 Feb. 2019, Peer-reviewed

  
• Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.

  Li-Hao Huang; Bernd H Zinselmeyer; Chih-Hao Chang; Brian T Saunders; Andrew Elvington; Osamu Baba; Thomas J Broekelmann; Lina Qi; Joseph S Rueve; Melody A Swartz; Brian S Kim; Robert P Mecham; Helge Wiig; Michael J Thomas; Mary G Sorci-Thomas; Gwendalyn J Randolph

  Cell metabolism, 05 Feb. 2019, Peer-reviewed

  
• Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction.

  Daihiko Hakuno; Masahiro Kimura; Shinji Ito; Junko Satoh; Yasuhiro Nakashima; Takahiro Horie; Yasuhide Kuwabara; Masataka Nishiga; Yuya Ide; Osamu Baba; Hitoo Nishi; Tetsushi Nakao; Tomohiro Nishino; Fumiko Nakazeki; Satoshi Koyama; Ritsuko Hanada; Ruiz R Randolph; Jin Endo; Takeshi Kimura; Koh Ono

  Scientific reports, 13 Nov. 2018, Peer-reviewed

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• SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo.

  Tomohiro Nishino; Takahiro Horie; Osamu Baba; Naoya Sowa; Ritsuko Hanada; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Manabu Nagata; Kazumichi Yoshida; Yasushi Takagi; Tomoyuki Nakamura; Koji Hasegawa; Susumu Miyamoto; Takeshi Kimura; Koh Ono

  Arteriosclerosis, thrombosis, and vascular biology, Oct. 2018, Peer-reviewed

  
• MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6Chigh Monocytes through Dual Pathways.

  Osamu Baba; Takahiro Horie; Tetsushi Nakao; Daihiko Hakuno; Yasuhiro Nakashima; Hitoo Nishi; Yasuhide Kuwabara; Masataka Nishiga; Tomohiro Nishino; Yuya Ide; Fumiko Nakazeki; Satoshi Koyama; Masahiro Kimura; Ritsuko Hanada; Masahiro Kawahara; Takeshi Kimura; Koh Ono

  Molecular and cellular biology, 15 Jul. 2018, Peer-reviewed, Lead author

  
• Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo.

  Fumiko Nakazeki; Masataka Nishiga; Takahiro Horie; Hitoo Nishi; Yasuhiro Nakashima; Osamu Baba; Yasuhide Kuwabara; Tomohiro Nishino; Tetsushi Nakao; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Shuhei Tsuji; Naoya Sowa; Shigeo Yoshida; Simon J Conway; Motoko Yanagita; Takeshi Kimura; Koh Ono

  Scientific reports, 04 Jun. 2018, Peer-reviewed

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• Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy.

  Mamoru Hayano; Takeru Makiyama; Tsukasa Kamakura; Hiroshi Watanabe; Kenichi Sasaki; Shunsuke Funakoshi; Yimin Wuriyanghai; Suguru Nishiuchi; Takeshi Harita; Yuta Yamamoto; Hirohiko Kohjitani; Sayako Hirose; Fumika Yokoi; Jiarong Chen; Osamu Baba; Takahiro Horie; Kazuhisa Chonabayashi; Seiko Ohno; Futoshi Toyoda; Yoshinori Yoshida; Koh Ono; Minoru Horie; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 24 Nov. 2017, Peer-reviewed

  
• Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways.

  Tetsushi Nakao; Takahiro Horie; Osamu Baba; Masataka Nishiga; Tomohiro Nishino; Masayasu Izuhara; Yasuhide Kuwabara; Hitoo Nishi; Shunsuke Usami; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Naoya Sowa; Satoko Ohno; Hiroki Aoki; Koji Hasegawa; Kazuhisa Sakamoto; Kenji Minatoya; Takeshi Kimura; Koh Ono

  Arteriosclerosis, thrombosis, and vascular biology, Nov. 2017, Peer-reviewed

  
• Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood.

  Jesse W Williams; Andrew Elvington; Stoyan Ivanov; Skyler Kessler; Hannah Luehmann; Osamu Baba; Brian T Saunders; Ki-Wook Kim; Michael W Johnson; Clarissa S Craft; Jae-Hoon Choi; Mary G Sorci-Thomas; Bernd H Zinselmeyer; Jonathan R Brestoff; Yongjian Liu; Gwendalyn J Randolph

  Circulation research, 01 Sep. 2017, Peer-reviewed

  
• Dynamic changes of serum microRNA-122-5p through therapeutic courses indicates amelioration of acute liver injury accompanied by acute cardiac decompensation.

  Satoshi Koyama; Takashi Kuragaichi; Yukihito Sato; Yasuhide Kuwabara; Shunsuke Usami; Takahiro Horie; Osamu Baba; Daihiko Hakuno; Yasuhiro Nakashima; Tomohiro Nishino; Masataka Nishiga; Tetsushi Nakao; Hidenori Arai; Takeshi Kimura; Koh Ono

  ESC heart failure, May 2017, Peer-reviewed

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• MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.

  Masataka Nishiga; Takahiro Horie; Yasuhide Kuwabara; Kazuya Nagao; Osamu Baba; Tetsushi Nakao; Tomohiro Nishino; Daihiko Hakuno; Yasuhiro Nakashima; Hitoo Nishi; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Ritsuko Hanada; Tomoyuki Nakamura; Tsukasa Inada; Koji Hasegawa; Simon J Conway; Toru Kita; Takeshi Kimura; Koh Ono

  Circulation research, 03 Mar. 2017, Peer-reviewed

  
• Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model.

  Masayasu Izuhara; Yasuhide Kuwabara; Naritatsu Saito; Erika Yamamoto; Daihiko Hakuno; Yasuhiro Nakashima; Takahiro Horie; Osamu Baba; Masataka Nishiga; Tetsushi Nakao; Tomohiro Nishino; Fumiko Nakazeki; Yuya Ide; Masahiro Kimura; Takeshi Kimura; Koh Ono

  PloS one, 2017, Peer-reviewed

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• Defensin-chemokine heteromeric complexes derived from heterocellular activation-a possible target to inhibit CCL5 in cardiovascular settings.

  Osamu Baba; Yongjian Liu; Gwendalyn J Randolph

  Annals of translational medicine, Dec. 2016, Peer-reviewed, Lead author

  
• High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.

  Masayasu Izuhara; Koh Ono; Hiroki Shiomi; Takeshi Morimoto; Yutaka Furukawa; Yoshihisa Nakagawa; Satoshi Shizuta; Tomohisa Tada; Junichi Tazaki; Takahiro Horie; Yasuhide Kuwabara; Osamu Baba; Tomohiro Nishino; Toru Kita; Takeshi Kimura

  Atherosclerosis, Oct. 2015, Peer-reviewed

  
• MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.

  Yasuhide Kuwabara; Takahiro Horie; Osamu Baba; Shin Watanabe; Masataka Nishiga; Shunsuke Usami; Masayasu Izuhara; Tetsushi Nakao; Tomohiro Nishino; Kinya Otsu; Toru Kita; Takeshi Kimura; Koh Ono

  Circulation research, 16 Jan. 2015, Peer-reviewed

  
• MicroRNA-33a/b in lipid metabolism – novel “thrifty” models.

  Koh Ono; Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Masayuki Yokode; Toru Kita; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 2015, Peer-reviewed

  
• MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism.

  Koh Ono; Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Takeshi Kimura

  International heart journal, 2015, Peer-reviewed

  
• Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery.

  Shoichi Miyamoto; Shunsuke Usami; Yasuhide Kuwabara; Takahiro Horie; Osamu Baba; Daihiko Hakuno; Yasuhiro Nakashima; Masataka Nishiga; Masayasu Izuhara; Tetsushi Nakao; Tomohiro Nishino; Yuya Ide; Fumiko Nakazeki; Jun Wang; Koji Ueyama; Takeshi Kimura; Koh Ono

  PloS one, 2015, Peer-reviewed

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• MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.

  Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Shunsuke Usami; Masayasu Izuhara; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Naoya Sowa; Naoya Yahagi; Hitoshi Shimano; Tomoyuki Nakamura; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  Scientific reports, 16 Jun. 2014, Peer-reviewed

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• MicroRNAs and Lipoprotein Metabolism.

  Takahiro Horie; Osamu Baba; Yasuhide Kuwabara; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  Journal of atherosclerosis and thrombosis, 2014, Peer-reviewed

  
• Cardiac-specific inhibition of kinase activity in calcium/calmodulin-dependent protein kinase kinase-β leads to accelerated left ventricular remodeling and heart failure after transverse aortic constriction in mice.

  Shin Watanabe; Takahiro Horie; Kazuya Nagao; Yasuhide Kuwabara; Osamu Baba; Hitoo Nishi; Naoya Sowa; Michiko Narazaki; Tetsuya Matsuda; Genzou Takemura; Hiromichi Wada; Koji Hasegawa; Takeshi Kimura; Koh Ono

  PloS one, 2014, Peer-reviewed

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• MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.

  Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Shunsuke Usami; Masayasu Izuhara; Naoya Sowa; Naoya Yahagi; Hitoshi Shimano; Shigenobu Matsumura; Kazuo Inoue; Hiroyuki Marusawa; Tomoyuki Nakamura; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  Nature communications, 2013, Peer-reviewed

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• MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.

  Takahiro Horie; Osamu Baba; Yasuhide Kuwabara; Yoshimasa Chujo; Shin Watanabe; Minako Kinoshita; Masahito Horiguchi; Tomoyuki Nakamura; Kazuhisa Chonabayashi; Masakatsu Hishizawa; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  Journal of the American Heart Association, Dec. 2012, Peer-reviewed, Lead author

  
• MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene.

  Naoya Sowa; Takahiro Horie; Yasuhide Kuwabara; Osamu Baba; Shin Watanabe; Hitoo Nishi; Minako Kinoshita; Rieko Takanabe-Mori; Hiromichi Wada; Akira Shimatsu; Koji Hasegawa; Takeshi Kimura; Koh Ono

  Journal of cellular biochemistry, Nov. 2012, Peer-reviewed

  
• マイクロRNA‐33は動脈硬化形成を制御する

  堀江貴裕; 馬場理; 尾野亘; 渡辺真; 西仁勇; 木下美菜子; 桑原康秀; 中條克真; 横出正之; 木村剛

  日本内科学会雑誌, 20 Feb. 2012

  
• ポストシークエンス時代の心脈管ゲノミクス 1 Non‐coding RNAと心血管疾患

  尾野亘; 堀江貴裕; 西仁勇; 木下美菜子; 桑原康秀; 馬場理; 木村剛

  血管, 11 Oct. 2011

  
• Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage.

  Yasuhide Kuwabara; Koh Ono; Takahiro Horie; Hitoo Nishi; Kazuya Nagao; Minako Kinoshita; Shin Watanabe; Osamu Baba; Yoji Kojima; Satoshi Shizuta; Masao Imai; Toshihiro Tamura; Toru Kita; Takeshi Kimura

  Circulation. Cardiovascular genetics, 01 Aug. 2011, Peer-reviewed

  
• The association between post-load low insulin level and high mortality rates in patients with no previous diagnosis of diabetes mellitus.

  Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito

  International journal of cardiology, 01 Apr. 2011, Peer-reviewed

  
• A case of marked ST depression and myocardial injury as a result of disulfiram-ethanol reaction.

  Keisuke Shioji; Masayasu Izuhara; Shin Kadota; Osamu Baba; Hirokazu Mitsuoka; Takashi Uegaito; Mitsuo Matsuda

  Journal of cardiology cases, Jun. 2010, Peer-reviewed

  
• A case of right atrial angiosarcoma: The utility of PET and CT fusion imaging in detecting a malignant cardiac tumor.

  Shin Kadota; Mitsuo Matsuda; Nao Umei; Masayasu Izuhara; Osamu Baba; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Takuma Satsu; Masahiko Onoe; Eiji Kadota

  Journal of cardiology cases, Apr. 2010, Peer-reviewed

  
• Determinant factors of plasma B-type natriuretic peptide levels in patients with persistent nonvalvular atrial fibrillation and preserved left ventricular systolic function.

  Osamu Baba; Masayasu Izuhara; Shin Kadota; Hirokazu Mitsuoka; Keisuke Shioji; Takashi Uegaito; Satoru Mutsuo; Mitsuo Matsuda

  Journal of cardiology, Dec. 2009, Peer-reviewed, Lead author

  
• Relationship of cardio-ankle vascular index (CAVI) to carotid and coronary arteriosclerosis.

  Masayasu Izuhara; Keisuke Shioji; Shin Kadota; Osamu Baba; Yuzo Takeuchi; Takashi Uegaito; Satoru Mutsuo; Mitsuo Matsuda

  Circulation journal : official journal of the Japanese Circulation Society, Nov. 2008, Peer-reviewed

  
• The importance of serial cardiac troponin measurement for evaluating the response to immunosuppressive therapy for myocarditis.

  Shin Kadota; Yuzo Takeuchi; Masayasu Izuhara; Osamu Baba; Keisuke Shioji; Takashi Uegaito; Eiji Kadota; Mitsuo Matsuda

  Journal of cardiology, Oct. 2008, Peer-reviewed

  
• Long-term effects of early statin therapy for patients with acute myocardial infarction treated with stent implantation.

  Shin Kadota; Mitsuo Matsuda; Masayasu Izuhara; Osamu Baba; Soji Moriwaki; Keisuke Shioji; Yuzo Takeuchi; Takashi Uegaito

  Journal of cardiology, Jun. 2008, Peer-reviewed

  
• Cardiac tamponade due to a ruptured solitary mediastinal varix: a case report.

  Toshio Kaneda; Masahiko Onoe; Soji Moriwaki; Shin Kadota; Osamu Baba; Mitsuo Matsuda; Eiji Kadota; Toshihiko Saga

  The heart surgery forum, 2007, Peer-reviewed

  

Misc.

• microRNA-33bの特異的抑制は炎症反応経路を介して腹部大動脈瘤形成を抑制する

  山崎智弘; 堀江貴裕; 小山智史; 中尾哲史; 馬場理; 曽和尚也; 小比賀聡; 小比賀聡; 笠原勇矢; 笠原勇矢; 小寺淳; 岡幸蔵; 藤田領; 佐々木隆史; 竹宮明広; 木村剛; 尾野亘

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 2022

  
• microRNA-33bの特異的抑制による腹部大動脈瘤形成抑制効果の検討

  山崎智弘; 堀江貴裕; 小山智; 中尾哲史; 馬場理; 曽和尚也; 小比賀聡; 小比賀聡; 笠原勇矢; 小寺淳; 岡幸蔵; 藤田領; 佐々木隆史; 竹宮明広; 木村剛; 尾野亘

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 2021

  
• セントルイス留学体験記

  馬場理

  The Lipid, 2020, Invited

  
• 海外文献紹介 -レビューと考察- 『血管内皮細胞におけるSR-B1はDOCK4との結合を介して、LDLコレステロールの血管壁への取り込みに寄与し、動脈硬化を促進する』

  馬場 理

  The Lipid, 2020, Invited, Corresponding author

  
• マイクロRNA‐33を介した新たな脂質代謝制御機構の解明

  堀江貴裕; 西野共達; 馬場理; 桑原康秀; 木村剛; 尾野亘

  血管, 31 Jan. 2016

  

Presentations

• A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells

  Osamu Baba

  ESC Congress 2024, 31 Aug. 2024

  
• A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells

  Osamu Baba

  第56回日本動脈硬化学会総会・学術集会, 07 Jul. 2024

  
• ケモカイン受容体特異的PETイメージングで見る動脈硬化プラーク

  馬場 理

  第56回日本動脈硬化学会総会・学術集会, 07 Jul. 2024, Invited

  
• Chemokine Receptor Targeting PET Imaging of Atherosclerosis

  Osamu Baba

  16th Asian Pacific Society of Atherosclerosis and Vascular Disease Congress 2023 (APSAVD2023), 08 Sep. 2023, Invited

  
• The CCR2 targeting peptide-based PET tracer, 64Cu-DOTA-ECL1i can non-invasively visualize monocytes and inflammatory macrophages in atherosclerotic plaque

  馬場理

  Cardiovascular And Metabolic Week 2021（CVMW2021）, 11 Dec. 2021, Invited

  
• The CCR2 targeting peptide-based PET tracer, 64Cu-DOTA-ECL1i can non-invasively visualize monocytes and inflammatory macrophages in atherosclerotic plaque

  馬場理

  The 19th International Symposium on Atherosclerosis（ISA2021）, 24 Oct. 2021

  
• The CCR2 targeting peptide-based PET tracer, 64Cu-DOTA-ECL1i can non-invasively visualize monocytes and inflammatory macrophages in atherosclerotic plaque

  馬場理

  第84回日本循環器学会学術集会, 07 Jul. 2020

  
• CXCR4 on Atherosclerotic Plaque Endothelium Predicts the Magnitude of Monocyte Recruitment and is Readily Targeted by PET Tracers

  馬場理

  第84回日本循環器学会学術集会, 07 Jul. 2020

  
• CXCR4 on aortic endothelium can be a novel marker of atherosclerosis activity detected by 64Cu-DOTA-vMIP-II PET tracer

  馬場理

  第51回日本動脈硬化学会総会・学術集会, 11 Jul. 2019, Invited

  
• Monocyte and macrophage dynamics in atherosclerotic plaques analyzed by PET imaging

  Osamu Baba

  Gordon Research Conference, Jun. 2017

  

External funds: Kakenhi

• Elucidating pathology of atherosclerosis by a novel CCR2-specific PET tracer and its clinical application

  Grant-in-Aid for Early-Career Scientists

  Basic Section 53020:Cardiology-related

  Kyoto University

  Osamu Baba

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  動脈硬化;PET;CCR2;マクロファージ;ケモカイン受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K17115/
• Analysis of the effect of microRNA-33 on bone marrow function and chronic inflammation

  Grant-in-Aid for Research Activity Start-up

  Kyoto University

  Osamu Baba

  From 28 Aug. 2015, To 31 Mar. 2017, Project Closed

  マイクロRNA;単球;HDLコレステロール;ABCA1;HMGA2;マイクロRNA-33;炎症性単球;造血幹細胞;循環器;免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H06335/
• CXCR7の動脈硬化における機能解明とPETによる臨床応用に向けて

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53020:Cardiology-related

  Kyoto University

  馬場 理

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  動脈硬化;非定型ケモカイン受容体;CXCR7;PET

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08154/
• Elucidation of the pathophysiology of aortic aneurysms and development of novel therapeutic agents to inhibit their progression and promote their regression

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53020:Cardiology-related

  Kyoto University

  尾野 亘

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  大動脈瘤;マイクロRNA;シングルセル解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02904/
• Elucidation of the pathophysiology of aortic aneurysms and development of novel therapeutic agents to inhibit their progression and promote their regression

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53020:Cardiology-related

  Kyoto University

  尾野 亘

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  大動脈瘤;マイクロRNA;シングルセル解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27595/