Basic Information

Faculty

• Faculty of Engineering

Email Address

• Email Address

  funato.yosuke.3ikyoto-u.ac.jp

Academic Degree

• 31 Mar. 2005

  東京大学修士（薬学）
• 24 Mar. 2008

  東京大学博士（機能薬学）

Academic Resume (Graduate Schools)

• 東京大学, 大学院薬学系研究科博士後期課程機能薬学専攻, 修了
• 東京大学, 大学院薬学系研究科修士課程機能薬学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 薬学部薬学科, 卒業

Research History

• From Feb. 2023, To Present

  Kyoto University, Graduate School of Engineering Department of Synthetic Chemistry and Biological Chemistry, 准教授

ID,URL

• J-Global ID

  201101032908113166

• Researcher number

  60505775

researchmap URL

• https://researchmap.jp/read0156495

Research

Research Areas

• Life sciences, Functional biochemistry
• Life sciences, Tumor biology
• Life sciences, Pathobiochemistry
• Life sciences, Medical biochemistry
• Life sciences, Cell biology

Papers

• Mg²⁺トランスポーターCNNMの生物学的重要性と治療標的としての可能性

  船戸 洋佑; 橋爪 脩; 山崎 大輔; 三木 裕明

  日本薬理学会年会要旨集, 2022

  
• がん細胞の新たな生存戦略としてのacid addictionとがん治療

  船戸 洋佑

  ファルマシア, 2021

  
• Development of a high-throughput screening system targeting the protein-protein interactions between PRL and CNNM.

  Yosuke Funato; Mai Mimura; Kazuto Nunomura; Bangzhong Lin; Shintarou Fujii; Junichi Haruta; Hiroaki Miki

  Scientific reports, 25 Oct. 2024

  Access this paper :

  
• Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure

  Yosuke Funato; Daisuke Yamazaki; Daisuke Okuzaki; Nobuhiko Yamamoto; Hiroaki Miki

  Nature Communications, Dec. 2021, Peer-reviewed, Lead author

  
• Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture

  Daisuke Yamazaki; Osamu Hashizume; Shiho Taniguchi; Yosuke Funato; Hiroaki Miki

  Scientific Reports, Dec. 2021, Peer-reviewed

  
• Intestinal Mg2+ accumulation induced by cnnm mutations decreases the body size by suppressing TORC2 signaling in Caenorhabditis elegans.

  Osamu Hashizume; Tomofumi Kawabe; Yosuke Funato; Hiroaki Miki

  Developmental biology, May 2024

  
• PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis.

  Kajung Ryu; Atsushi Yoshida; Yosuke Funato; Daisuke Yamazaki; Hiroaki Miki

  Cell structure and function, 05 Nov. 2022

  
• Phosphatase-independent role of phosphatase of regenerating liver in cancer progression.

  Yosuke Funato; Osamu Hashizume; Hiroaki Miki

  Cancer science, 26 Oct. 2022

  
• A novel role for PRL in regulating epithelial cell density by inducing apoptosis at confluence.

  Sweksha Lohani; Yosuke Funato; Yuki Akieda; Kiyohito Mizutani; Yoshimi Takai; Tohru Ishitani; Hiroaki Miki

  Journal of cell science, 15 Jan. 2022, Peer-reviewed

  
• The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters.

  Yosuke Funato; Hiroaki Miki

  Journal of pharmacological sciences, Jan. 2022, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Identification and mechanistic analysis of an inhibitor of the CorC Mg²⁺ transporter

  Yichen Huang; Kaijie Mu; Xinyu Teng; Yimeng Zhao; Yosuke Funato; Hiroaki Miki; Weiliang Zhu; Zhijian Xu; Motoyuki Hattori

  iScience, 23 Apr. 2021, Peer-reviewed

  
• Structural basis for the Mg²⁺ recognition and regulation of the CorC Mg²⁺ transporter

  Yichen Huang; Fei Jin; Yosuke Funato; Zhijian Xu; Weiliang Zhu; Jing Wang; Minxuan Sun; Yimeng Zhao; Ye Yu; Hiroaki Miki; Motoyuki Hattori

  Science Advances, 10 Feb. 2021, Peer-reviewed, Lead author

  
• The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis

  Yosuke Funato; Atsushi Yoshida; Yusuke Hirata; Osamu Hashizume; Daisuke Yamazaki; Hiroaki Miki

  Developmental Cell, 23 Nov. 2020, Peer-reviewed, Lead author, Corresponding author

  
• Magnesium efflux from drosophila kenyon cells is critical for normal and diet-enhanced long-term memory

  Yanying Wu; Yosuke Funato; Eleonora Meschi; Kristijan D. Jovanoski; Hiroaki Miki; Scott Waddell

  eLife, Oct. 2020, Peer-reviewed

  
• PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth

  Guennadi Kozlov; Yosuke Funato; Yu Seby Chen; Zhidian Zhang; Katalin Illes; Hiroaki Miki; Kalle Gehring

  Journal of Biological Chemistry, 14 Aug. 2020, Peer-reviewed, Lead author

  
• Excessive Mg²⁺ Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species

  Osamu Hashizume; Yosuke Funato; Daisuke Yamazaki; Hiroaki Miki

  Antioxidants and Redox Signaling, 01 Jul. 2020, Peer-reviewed, Corresponding author

  
• Control of protein function through oxidation and reduction of persulfidated states

  Dóka; T. Ida; M. Dagnell; Y. Abiko; N. C. Luong; N. Balog; T. Takata; B. Espinosa; A. Nishimura; Q. Cheng; Y. Funato; H. Miki; J. M. Fukuto; J. R. Prigge; E. E. Schmidt; E. S.J. Arnér; Y. Kumagai; T. Akaike; P. Nagy

  Science Advances, 01 Jan. 2020, Peer-reviewed

  
• Phosphatase of regenerating liver sensitizes MET to functional activation by hepatocyte growth factor

  Takuya Kojima; Yosuke Funato; Hiroaki Miki

  Biochemical Journal, 21 May 2019, Peer-reviewed, Corresponding author

  
• Cnnm4 deficiency suppresses Ca²⁺ signaling and promotes cell proliferation in the colon epithelia

  Daisuke Yamazaki; Ayaka Hasegawa; Yosuke Funato; Ha Nam Tran; Masayuki X. Mori; Yasuo Mori; Toshiro Sato; Hiroaki Miki

  Oncogene, 16 May 2019, Peer-reviewed

  
• Molecular function and biological importance of CNNM family Mg ²⁺ transporters

  Yosuke Funato; Hiroaki Miki

  Journal of Biochemistry, 01 Mar. 2019, Peer-reviewed, Lead author

  
• The cyclic nucleotide– binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg² efflux activity

  Yu Seby Chen; Guennadi Kozlov; Rayan Fakih; Yosuke Funato; Hiroaki Miki; Kalle Gehring

  Journal of Biological Chemistry, 28 Dec. 2018, Peer-reviewed

  
• Phosphatase of regenerating liver maintains cellular magnesium homeostasis

  Atsushi Yoshida; Yosuke Funato; Hiroaki Miki

  Biochemical Journal, 30 Mar. 2018, Peer-reviewed

  
• CrossTalk proposal: CNNM proteins are Na ⁺ /Mg ²⁺ exchangers playing a central role in transepithelial Mg ²⁺ (re)absorption

  Yosuke Funato; Kazuharu Furutani; Yoshihisa Kurachi; Hiroaki Miki

  Journal of Physiology, 01 Mar. 2018, Peer-reviewed, Lead author, Corresponding author

  
• Renal function of cyclin M2 Mg²⁺ transporter maintains blood pressure

  Yosuke Funato; Daisuke Yamazaki; Hiroaki Miki

  Journal of Hypertension, 2017, Peer-reviewed, Lead author

  
• Visualization of long-term Mg²⁺ dynamics in apoptotic cells using a novel targetable fluorescent probe

  Yusuke Matsui; Yosuke Funato; Hiromi Imamura; Hiroaki Miki; Shin Mizukami; Kazuya Kikuchi

  Chemical Science, 2017, Peer-reviewed

  
• Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis

  Irina Gulerez; Yosuke Funato; Howie Wu; Meng Yang; Guennadi Kozlov; Hiroaki Miki; Kalle Gehring

  EMBO Reports, 01 Dec. 2016, Peer-reviewed, Lead author

  
• Mg²⁺ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans

  Tasuku Ishii; Yosuke Funato; Osamu Hashizume; Daisuke Yamazaki; Yusuke Hirata; Kiyoji Nishiwaki; Nozomu Kono; Hiroyuki Arai; Hiroaki Miki

  PLoS Genetics, Aug. 2016, Peer-reviewed, Corresponding author

  
• Complementary role of CNNM2 in sperm motility and Ca²⁺ influx during capacitation

  Daisuke Yamazaki; Yosuke Funato; Haruhiko Miyata; Masahito Ikawa; Hiroaki Miki

  Biochemical and Biophysical Research Communications, 03 Jun. 2016, Peer-reviewed

  
• The Mg²⁺ transporter CNNM4 regulates sperm Ca²⁺ homeostasis and is essential for reproduction

  Daisuke Yamazaki; Haruhiko Miyata; Yosuke Funato; Yoshitaka Fujihara; Masahito Ikawa; Hiroaki Miki

  Journal of Cell Science, 01 May 2016, Peer-reviewed

  
• Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression

  Yosuke Funato; Daisuke Yamazaki; Shin Mizukami; Lisa Du; Kazuya Kikuchi; Hiroaki Miki

  JOURNAL OF CLINICAL INVESTIGATION, Dec. 2014, Peer-reviewed, Lead author

  
• Basolateral sorting of the Mg2+ transporter CNNM4 requires interaction with AP-1A and AP-1B

  Yusuke Hirata; Yosuke Funato; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2014, Peer-reviewed

  
• Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data

  Katsuyuki Yugi; Hiroyuki Kubota; Yu Toyoshima; Rei Noguchi; Kentaro Kawata; Yasunori Komori; Shinsuke Uda; Katsuyuki Kunida; Yoko Tomizawa; Yosuke Funato; Hiroaki Miki; Masaki Matsumoto; Keiichi I. Nakayama; Kasumi Kashikura; Keiko Endo; Kazutaka Ikeda; Tomoyoshi Soga; Shinya Kuroda

  CELL REPORTS, Aug. 2014, Peer-reviewed

  
• Mg2+ -dependent Interactions of ATP with the Cystathionine-beta-Synthase (CBS) Domains of a Magnesium Transporter

  Yusuke Hirata; Yosuke Funato; Yu Takano; Hiroaki Miki

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2014, Peer-reviewed

  
• Reversible oxidation of PRL family protein-tyrosine phosphatases

  Yosuke Funato; Hiroaki Miki

  METHODS, Jan. 2014, Peer-reviewed, Lead author

  
• Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1

  Yosuke Funato; Tatsuya Hayashi; Yasuhiro Irino; Tadaomi Takenawa; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2013, Peer-reviewed

  
• Thioredoxin-related Protein 32 (TRP32) Specifically Reduces Oxidized Phosphatase of Regenerating Liver (PRL)

  Tasuku Ishii; Yosuke Funato; Hiroaki Miki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2013, Peer-reviewed

  
• [Redox-dependent regulation of intracellular signaling via nucleoredoxin].

  Funato Y; Miki H

  Seikagaku. The Journal of Japanese Biochemical Society, Mar. 2013, Peer-reviewed

  
• Basolateral Mg2+ Extrusion via CNNM4 Mediates Transcellular Mg2+ Transport across Epithelia: A Mouse Model

  Daisuke Yamazaki; Yosuke Funato; Jiro Miura; Sunao Sato; Satoru Toyosawa; Kazuharu Furutani; Yoshihisa Kurachi; Yoshihiro Omori; Takahisa Furukawa; Tetsuya Tsuda; Susumu Kuwabata; Shin Mizukami; Kazuya Kikuchi; Hiroaki Miki

  PLoS Genetics, 2013, Peer-reviewed, Lead author

  
• Regulation of intracellular signalling through cysteine oxidation by reactive oxygen species

  Hiroaki Miki; Yosuke Funato

  JOURNAL OF BIOCHEMISTRY, Mar. 2012, Peer-reviewed

  
• Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis

  A. Morinaka; Y. Funato; K. Uesugi; H. Miki

  ONCOGENE, Oct. 2011, Peer-reviewed

  
• Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse

  Akifumi Morinaka; Mayumi Yamada; Rurika Itofusa; Yosuke Funato; Yuta Yoshimura; Fumio Nakamura; Takeshi Yoshimura; Kozo Kaibuchi; Yoshio Goshima; Mikio Hoshino; Hiroyuki Kamiguchi; Hiroaki Miki

  Science Signaling, 26 Apr. 2011, Peer-reviewed

  
• An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease

  Linda Müller; Yosuke Funato; Hiroaki Miki; Richard Zimmermann

  FEBS Letters, 18 Feb. 2011, Peer-reviewed

  
• Nucleoredoxin Sustains Wnt/beta-Catenin Signaling by Retaining a Pool of Inactive Dishevelled Protein

  Yosuke Funato; Takeshi Terabayashi; Reiko Sakamoto; Daisuke Okuzaki; Hirotake Ichise; Hiroshi Nojima; Nobuaki Yoshida; Hiroaki Miki

  CURRENT BIOLOGY, Nov. 2010, Peer-reviewed

  
• Nucleoredoxin Negatively Regulates Toll-like Receptor 4 Signaling via Recruitment of Flightless-I to Myeloid Differentiation Primary Response Gene (88)

  Tatsuya Hayashi; Yosuke Funato; Takeshi Terabayashi; Akifumi Morinaka; Reiko Sakamoto; Hirotake Ichise; Hiroyuki Fukuda; Nobuaki Yoshida; Hiroaki Miki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2010, Peer-reviewed

  
• Redox regulation of Wnt signalling via nucleoredoxin

  Yosuke Funato; Hiroaki Miki

  FREE RADICAL RESEARCH, Apr. 2010, Peer-reviewed

  
• Discovery of Candidate Disease Genes in ENU-Induced Mouse Mutants by Large-Scale Sequencing, Including a Splice-Site Mutation in Nucleoredoxin

  Melissa K. Boles; Bonney M. Wilkinson; Laurens G. Wilming; Bin Liu; Frank J. Probst; Jennifer Harrow; Darren Grafham; Kathryn E. Hentges; Lanette P. Woodward; Andrea Maxwell; Karen Mitchell; Michael D. Risley; Randy Johnson; Karen Hirschi; James R. Lupski; Yosuke Funato; Hiroaki Miki; Pablo Marin-Garcia; Lucy Matthews; Alison J. Coffey; Anne Parker; Tim J. Hubbard; Jane Rogers; Allan Bradley; David J. Adams; Monica J. Justice

  PLOS GENETICS, Dec. 2009, Peer-reviewed

  
• A Coated Vesicle-associated Kinase of 104 kDa (CVAK104) Induces Lysosomal Degradation of Frizzled 5 (Fzd5)

  Takeshi Terabayashi; Yosuke Funato; Mitsunori Fukuda; Hiroaki Miki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2009, Peer-reviewed

  
• Dishevelled-induced phosphorylation regulates membrane localization of Par1b

  Takeshi Terabayashi; Yosuke Funato; Hiroaki Miki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2008, Peer-reviewed

  
• Nucleoredoxin regulates the Wnt/planar cell polarity pathway in Xenopus

  Yosuke Funato; Tatsuo Michiue; Takeshi Terabayashi; Akira Yukita; Hiroki Danno; Makoto Asashima; Hiroaki Miki

  GENES TO CELLS, Sep. 2008, Peer-reviewed, Lead author

  
• Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons

  Takeshi Terabayashi; Tomohiko J. Itoh; Hideki Yamaguchi; Yuta Yoshimura; Yosuke Funato; Shigeo Ohno; Hiroaki Miki

  JOURNAL OF NEUROSCIENCE, Nov. 2007, Peer-reviewed

  
• Nucleoredoxin, a novel thioredoxin family member involved in cell growth and differentiation

  Yosuke Funato; Hiroaki Miki; Arne Holmgren; Hajime Nakamura; Lloyd Ruddock; Junichi Sadoshima

  ANTIOXIDANTS & REDOX SIGNALING, Aug. 2007, Peer-reviewed

  
• [Regulation of Wnt signal pathway via nucleoredoxin].

  Funato Y; Miki H

  Seikagaku. The Journal of Japanese Biochemical Society, Aug. 2007, Peer-reviewed

  
• The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled

  Y Funato; T Michiue; M Asashima; H Miki

  NATURE CELL BIOLOGY, May 2006, Peer-reviewed, Lead author

  
• IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness

  Y Funato; T Terabayashi; N Suenaga; M Seiki; T Takenawa; H Miki

  CANCER RESEARCH, Aug. 2004, Peer-reviewed, Lead author

  

Misc.

• Rebuttal from Yosuke Funato, Kazuharu Furutani, Yoshihisa Kurachi and Hiroaki Miki

  Yosuke Funato; Kazuharu Furutani; Yoshihisa Kurachi; Hiroaki Miki

  Journal of Physiology, 01 Mar. 2018

  

Presentations

• マグネシウムへの「応答」を介した血圧制御

  船戸洋佑; 橋爪脩; 三木裕明

  第67回日本腎臓学会学術総会, 28 Jun. 2024, Invited

  
• pHが織りなすがん生物学

  船戸洋佑; 橋爪脩; 三木裕明

  日本生理学会第100回記念大会, 15 Mar. 2023, Invited

  
• pH/CO2 がもたらした有機物創成と生命の pH 適応戦略

  高橋重成; 船戸洋佑

  pH/CO2が支える地球上の生命, 02 Oct. 2022, Invited

  
• マグネシウム輸送体を介した腎臓からの血圧日周変動制御の機構解明

  船戸洋佑、三木裕明

  ソルト・サイエンス研究財団 第34回助成研究発表会, Jul. 2022, Invited

  
• 上皮膜上のMg2+排出分子CNNMの阻害を介した腫瘍内酸性環境への適応機構

  船戸洋佑、橋爪脩、三木裕明

  2022年度生理研研究会「上皮膜輸送と細胞極性形成機構の統合的理解を目指して」, Jul. 2022, Invited

  
• 演題名：生命がマグネシウムに応答する仕組みの解明

  船戸洋佑

  JST創発的研究支援事業「融合の場」第１回公開シンポジウム, Jun. 2022, Invited

  
• Maintenance of magnesium homeostasis by CNNM and various diseases caused by its disruption

  Yosuke Funato, Osamu Hashizume, Daisuke Yamazaki, Hiroaki Miki

  第99回日本生理学会大会, Mar. 2022, Invited

  
• Mg2+トランスポーターCNNMの生物学的重要性と治療標的としての可能性

  船戸洋佑、橋爪脩、山崎大輔、三木裕明

  第95回日本薬理学会年会, Mar. 2022, Invited

  
• がん細胞の酸性環境適応機構「acid addiction」の分子メカニズム解析

  船戸洋佑、本田茉子、山崎大輔、三木裕明

  第94回日本生化学会大会, Nov. 2021, Invited

  

Awards

• 14 Jul. 2015

  第4回大阪大学総長奨励賞（研究部門）
• 02 Aug. 2013

  第2回大阪大学総長奨励賞（研究部門）

External funds: Kakenhi

• Acid adaptation of cells via lysosomal exocytosis

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48040:Medical biochemistry-related

  Kyoto University;Osaka University

  Yosuke Funato

  From 01 Apr. 2020, To 31 Mar. 2024, Project Closed

  PRL;がん悪性化;酸性環境適応;lysosomal exocytosis;酸性適応;リソソーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07312/
• The general importance of lysosomal exocytosis in acid adaptation

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University;Osaka University

  Yosuke Funato

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  酸性環境適応;lysosomal exocytosis;PRL;リソソーム;酸性適応;pH応答生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05789/
• Establishment of pH Biology

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  Nobuaki Takakahashi

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  pH;pHストレス適応;シグナル伝達;がん;発生;海洋酸性化;pH適応;転写因子

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-20H05787/
• リソソームを介した生命金属動態制御とシグナル伝達

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Osaka University

  船戸 洋佑

  From 01 Apr. 2020, To 31 Mar. 2021, Discontinued

  酸性適応;リソソーム;亜鉛;PRL

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05508/
• Cysteine phosphorylation: elucidating the mechanism and significance of a novel post-translational modification

  Grant-in-Aid for Challenging Research (Exploratory)

  Osaka University

  Funato Yosuke

  From 30 Jun. 2017, To 31 Mar. 2021, Project Closed

  Cysリン酸化;システイン;リン酸化;PRL;翻訳後修飾;lysosomal exocytosis;pH応答;細胞密度;CNNM;酸性適応;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19396/
• Regulation of glucose metabolism pathway by nucleoredoxin

  Grant-in-Aid for Scientific Research (C)

  Osaka University

  Yosuke Funato

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  nucleoredoxin;代謝;グルコース;グルコース代謝;NRX;活性酸素;PFK;レドックス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460364/
• Molecular mechanism regulating intracellular and organismal magnesium levels

  Grant-in-Aid for Scientific Research (B)

  Osaka University

  Hiroaki MIKI

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  マグネシウム;ストレス;癌;循環器・高血圧

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26291042/
• Magnesium absorption by MagEx

  Grant-in-Aid for Challenging Exploratory Research

  Osaka University

  Yosuke FUNATO

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  膜輸送と輸送タンパク質;マグネシウム;恒常性;トランスポーター;局在制御;MagEx

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24657090/
• ＰＲＬ／ＭａｇＥｘ複合体による酸化ストレス応答

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Osaka University

  船戸 洋佑

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  PRL;酸化修飾;TRP32;マグネシウム;がん転移

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23117710/
• Characterization of PRL as a redox-sensing molecule

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  Yosuke FUNATO

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  細胞内情報伝達;PRL;マグネシウム;がん転移;MEP50;PSMC6

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22770195/
• Nucleoredoxinファミリーによる活性酸素応答機構

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Osaka University

  船戸 洋佑

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  nucleoredoxin;Wnt;Dishevelled;NRX;Fli-I;TRX

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21117510/
• nucleoredoxin(NRX)とその類似分子の機能解析

  Grant-in-Aid for Young Scientists (Start-up)

  Osaka University

  船戸 洋佑

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  nucleoredoxin(NRX);ノックアウトマウス;Wnt;Dishevelled(Dvl);骨芽細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20870026/
• Lysosomal exocytosisを基軸としたがん細胞の酸性環境適応機構の全容解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 48040:Medical biochemistry-related

  Kyoto University

  船戸 洋佑

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  リソソーム;がん悪性化;プロトン;lysosomal exocytosis;酸性環境適応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02225/
• pH signal via extracellular proton field formation

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  船戸 洋佑

  From 01 Apr. 2025, To 31 Mar. 2030, Granted

  プロトン;シグナル伝達;がん;発生

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25H01335/
• pH応答生物学の確立

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Institute of Physical and Chemical Research

  荻沼 政之

  From 01 Apr. 2025, To 31 Mar. 2030, Granted

  pH;ストレス;シグナル;海洋酸性化;光遺伝学

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-25H01330/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Biochemistry I (Advanced Chemistry)

  7416, Spring, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Biochemistry II

  7064, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Biorecognics

  H815, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Biochemistry I (Advanced Chemistry)

  7416, Spring, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Biochemistry II

  7064, Fall, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Biochemistry I (Advanced Chemistry)

  7416, Spring, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3

Academic, Social Contribution

Academic Contribution

• 第９５回日本薬理学会年会シンポジウム「創薬に向けたカチオントランスポーター研究の新たな展開」

  Panel moderator

  第９５回日本薬理学会年会, From Mar. 2022, To Mar. 2022

  
• 第９４回日本生化学会大会シンポジウム「学際的研究から切り拓くpH生物学のフロンティア」

  Panel moderator

  第９４回日本生化学会大会, From Nov. 2021, To Nov. 2021

  
• 第９３回日本生化学会大会シンポジウム「酸応答・適応機構の先駆的研究」

  Panel moderator

  日本生化学会, From Sep. 2020