Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 感染防御生物学, 教授
• Graduate School of Medicine, 医科学専攻 感染防御生物学, 教授

Faculty

• 医学部

Professional Memberships

• From 2024, To Present

  日本サイトカイン学会
• From 2019, To Present

  日本核酸医薬学会
• From 2011, To Present

  日本RNA学会
• From 1998, To Present

  日本分子生物学会
• From 1998, To Present

  日本生化学会
• From Oct. 1998, To Present

  Japanese Society for Immunology

Academic Degree

• (Osaka University)

Research History

• From Oct. 2018, To Present

  Kyoto University, Graduate School of Medicine, 教授
• From Apr. 2012, To Sep. 2018

  Kyoto University, ウイルス・再生医科学研究所, 教授
• From 2007, To 2012

  Osaka University, Research Institute for Microbial Diseases, 准教授
• From Apr. 2004, To Mar. 2007

  Osaka University, Research Institute for Microbial Diseases, 助教
• From Apr. 2002, To Mar. 2004

  Harvard University, Post doctoral fellow

ID,URL

• J-Global ID

  201201008533281839

• External link

  https://mc.mfour.med.kyoto-u.ac.jp/

Website(s) (URL(s))

• https://mc.mfour.med.kyoto-u.ac.jp/

researchmap URL

• https://researchmap.jp/otakeuti

Research

Research Topics, Overview of the research

• Research Topics

  Identification of regulatory mechanisms of inflammation via innate immunity

• Overview of the research

  Innate immunity is critical not only for early recognition of pathogens, but also for evoking inflammation in response to various stresses. I have been analyzing molecular mechanisms regulating inflammation by focusing on (1) cytokine regulation via mRNA stability, (2) Toll-like receptor (TLR) signal transduction mechanisms and (3) regulation of gene transcription downstream of TLR using mouse models.

Research Interests

• Toll-like receptor
• シグナル伝達
• ヘリカーゼ
• 樹状細胞
• Zc3h12a
• プロテオソーム
• インターフェロン
• RNA安定性
• ウイルス
• 自己免疫疾患
• 自然免疫
• オートファジー
• 炎症
• H3K27メチル化
• 病原体センサー
• エピジェネティクス

Research Areas

• Life sciences, Medical biochemistry
• Life sciences, Immunology

Papers

• 【RNAバイオロジーの最前線】RNA認識による自然免疫応答

  植畑 拓也; 竹内 理

  生化学, Dec. 2024

  
• A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.

  Kazuko Miyazaki; Kenta Horie; Hitomi Watanabe; Reiko Hidaka; Rinako Hayashi; Norihito Hayatsu; Kentaro Fujiwara; Rei Kuwata; Takuya Uehata; Yotaro Ochi; Makoto Takenaka; Risa Karakida Kawaguchi; Koichi Ikuta; Osamu Takeuchi; Seishi Ogawa; Katsuto Hozumi; Georg A Holländer; Gen Kondoh; Taishin Akiyama; Masaki Miyazaki

  Genes & development, 04 Feb. 2025

  
• A Novel Missense Variant of <i>ZC3H12A</i> in Pulmonary Arterial Hypertension

  Ryotaro Asano; Makoto Okazawa; Tomohiko Ishibashi; Xin Ding; Keiko Ohta-Ogo; Kotaro Akaki; Saori Umeki-Mizushima; Akiko Yamagishi; Tadakatsu Inagaki; Ai Yaku; Shinya Fujisaki; Takatoyo Kiko; Kinta Hatakeyama; Osamu Takeuchi; Takeshi Ogo; Yoshikazu Nakaoka

  Circulation Reports, 31 Jan. 2025

  
• 【自然免疫の最前線】自然免疫応答のプラットホーム RNA分解酵素による自然免疫応答のフィードバック制御

  植畑 拓也; 竹内 理

  医学のあゆみ, Jun. 2018

  
• UPF1 plays critical roles in early B cell development.

  Noriki Iwai; Kotaro Akaki; Fabian Hia; Wei Li; Masanori Yoshinaga; Takashi Mino; Osamu Takeuchi

  Nature communications, 09 Jul. 2024

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• TAK1-binding protein 2 (TAB2) and TAB3 are redundantly required for TLR-induced cytokine production in macrophages

  Tanveer Ali; Huong Minh Nguyen; Naeem Abbas; Osamu Takeuchi; Shizuo Akira; Toshihiko Suzuki; Goro Matsuzaki; Giichi Takaesu

  International Immunology, 13 Aug. 2024

  
• Regulation of inflammatory diseases via the control of mRNA decay

  Masanori Yoshinaga; Osamu Takeuchi

  Inflammation and Regeneration, 15 Mar. 2024

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• RNA Metabolism Governs Immune Function and Response.

  Masanori Yoshinaga; Osamu Takeuchi

  Advances in experimental medicine and biology, 2024

  
• Receptors | Toll-like receptors

  Kumar, H.; Takeuchi, O.; Akira, S.; Schaffer, J.E.

  Encyclopedia of Biological Chemistry: Third Edition, 2021

  
• Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated control of Nfkbiz

  Takuya Uehata; Shinnosuke Yamada; Daisuke Ori; Alexis Vandenbon; Amir Giladi; Adam Jelinski; Yasuhiro Murakawa; Hitomi Watanabe; Kazuhiro Takeuchi; Kazunori Toratani; Takashi Mino; Hisanori Kiryu; Daron M. Standley; Tohru Tsujimura; Tomokatsu Ikawa; Gen Kondoh; Markus Landthaler; Hiroshi Kawamoto; Hans-Reimer Rodewald; Ido Amit; Ryo Yamamoto; Masaki Miyazaki; Osamu Takeuchi

  Blood, 18 Jan. 2024, Peer-reviewed, Last author, Corresponding author

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• Regnase-1 plays an essential role in maintaining skin immune homeostasis via regulation of chemokine expression.

  Gabsik Yang; Hye Eun Lee; Magdalena Trzeciak; Tadeusz Pawelczyk; Osamu Takeuchi; Han Chang Kang; Yong-Yeon Cho; Hye Suk Lee; Joo Young Lee

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Jun. 2023, Peer-reviewed

  
• Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins.

  Ka Man Tse; Osamu Takeuchi

  Archives of pharmacal research, Feb. 2023, Peer-reviewed, Invited, Last author, Corresponding author

  
• 免疫学 RNA分解酵素Regnase-1を標的とした炎症制御法の開発

  吉永 正憲; 竹内 理

  医学のあゆみ, Jan. 2023

  
• The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.

  Masanori Yoshinaga; Kyuho Han; David W Morgens; Takuro Horii; Ryosuke Kobayashi; Tatsuaki Tsuruyama; Fabian Hia; Shota Yasukura; Asako Kajiya; Ting Cai; Pedro H C Cruz; Alexis Vandenbon; Yutaka Suzuki; Yukio Kawahara; Izuho Hatada; Michael C Bassik; Osamu Takeuchi

  Nature communications, 28 Oct. 2022, Peer-reviewed, Last author, Corresponding author

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• DSP-crosslinking and Immunoprecipitation to Isolate Weak Protein Complex

  Kotaro Akaki; Takashi Mino; Osamu Takeuchi

  BIO-PROTOCOL, 2022, Peer-reviewed, Invited, Last author, Corresponding author

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• Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.

  Ai Yaku; Tadakatsu Inagaki; Ryotaro Asano; Makoto Okazawa; Hiroyoshi Mori; Ayuko Sato; Fabian Hia; Takeshi Masaki; Yusuke Manabe; Tomohiko Ishibashi; Alexis Vandenbon; Yoshinari Nakatsuka; Kotaro Akaki; Masanori Yoshinaga; Takuya Uehata; Takashi Mino; Satoshi Morita; Hatsue Ishibashi-Ueda; Akio Morinobu; Tohru Tsujimura; Takeshi Ogo; Yoshikazu Nakaoka; Osamu Takeuchi

  Circulation, 23 Aug. 2022, Peer-reviewed, Last author, Corresponding author

  
• Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells.

  Aki Ejima; Shinya Abe; Akihiro Shimba; Susumu Sato; Takuya Uehata; Shizue Tani-Ichi; Satoru Munakata; Guangwei Cui; Osamu Takeuchi; Toyohiro Hirai; Shigeaki Kato; Koichi Ikuta

  Journal of immunology (Baltimore, Md. : 1950), 17 Aug. 2022, Peer-reviewed

  
• Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases.

  Ka Man Tse; Alexis Vandenbon; Xiaotong Cui; Takashi Mino; Takuya Uehata; Keiko Yasuda; Ayuko Sato; Tohru Tsujimura; Fabian Hia; Masanori Yoshinaga; Makoto Kinoshita; Tatsusada Okuno; Osamu Takeuchi

  Science translational medicine, 11 May 2022, Peer-reviewed, Last author, Corresponding author

  
• Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism.

  Yee Kien Chong; Sarang Tartey; Yuki Yoshikawa; Koshi Imami; Songling Li; Masanori Yoshinaga; Ai Hirabayashi; Guohao Liu; Alexis Vandenbon; Fabian Hia; Takuya Uehata; Takashi Mino; Yutaka Suzuki; Takeshi Noda; Dominique Ferrandon; Daron M Standley; Yasushi Ishihama; Osamu Takeuchi

  Science signaling, 12 Apr. 2022, Peer-reviewed, Last author, Corresponding author

  
• Regnase-1-related endoribonucleases in health and immunological diseases.

  Takashi Mino; Osamu Takeuchi

  Immunological reviews, 12 Sep. 2021, Peer-reviewed, Invited, Last author, Corresponding author

  
• Post-transcriptional regulation of immunological responses by Regnase-1-related RNases.

  Takuya Uehata; Osamu Takeuchi

  International immunology, 28 Jul. 2021, Peer-reviewed, Invited, Last author, Corresponding author

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• Extracellular mRNA transported to the nucleus exerts translation-independent function.

  Takeshi Tomita; Masayoshi Kato; Taishi Mishima; Yuta Matsunaga; Hideki Sanjo; Ken-Ichi Ito; Kentaro Minagawa; Toshimitsu Matsui; Hiroyuki Oikawa; Satoshi Takahashi; Toshifumi Takao; Noriki Iwai; Takashi Mino; Osamu Takeuchi; Yoshiro Maru; Sachie Hiratsuka

  Nature communications, 16 Jun. 2021, Peer-reviewed

  
• PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.

  Ankur Garg; Yvette Roske; Shinnosuke Yamada; Takuya Uehata; Osamu Takeuchi; Udo Heinemann

  Nucleic acids research, 05 May 2021, Peer-reviewed

  
• Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-1.

  Yoshinari Nakatsuka; Ai Yaku; Tomohiro Handa; Alexis Vandenbon; Yuki Hikichi; Yasutaka Motomura; Ayuko Sato; Masanori Yoshinaga; Kiminobu Tanizawa; Kizuku Watanabe; Toyohiro Hirai; Kazuo Chin; Yutaka Suzuki; Takuya Uehata; Takashi Mino; Tohru Tsujimura; Kazuyo Moro; Osamu Takeuchi

  The European respiratory journal, Mar. 2021, Peer-reviewed, Last author, Corresponding author

  
• The effects of codon bias and optimality on mRNA and protein regulation.

  Fabian Hia; Osamu Takeuchi

  Cellular and molecular life sciences : CMLS, Mar. 2021, Peer-reviewed, Last author, Corresponding author

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• The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells.

  Kazuko Miyazaki; Hitomi Watanabe; Genki Yoshikawa; Kenian Chen; Reiko Hidaka; Yuki Aitani; Kai Osawa; Rie Takeda; Yotaro Ochi; Shizue Tani-Ichi; Takuya Uehata; Osamu Takeuchi; Koichi Ikuta; Seishi Ogawa; Gen Kondoh; Yin C Lin; Hiroyuki Ogata; Masaki Miyazaki

  Science immunology, 04 Sep. 2020, Peer-reviewed

  
• RNA Recognition and Immunity-Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms.

  Takuya Uehata; Osamu Takeuchi

  Cells, 16 Jul. 2020, Peer-reviewed, Invited, Last author, Corresponding author

  
• Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages

  Kenta Maruyama; Hiroyasu Kidoya; Naoki Takemura; Erika Sugisawa; Osamu Takeuchi; Takeshi Kondo; Mohammed Mansour Abbas Eid; Hiroki Tanaka; Mikaël M. Martino; Nobuyuki Takakura; Yasunori Takayama; Shizuo Akira; Alexis Vandenbon; Yutaro Kumagai

  Cell Reports, Jul. 2020, Peer-reviewed

  
• Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch

  Jingchi Gao; Yuichiro Hori; Osamu Takeuchi; Kazuya Kikuchi

  Bioconjugate Chemistry, 18 Mar. 2020, Peer-reviewed

  
• Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis

  Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M. Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa

  Nature, 09 Jan. 2020, Peer-reviewed

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• Codon bias confers stability to human mRNAs

  Fabian Hia; Sheng Fan Yang; Yuichi Shichino; Masanori Yoshinaga; Yasuhiro Murakawa; Alexis Vandenbon; Akira Fukao; Toshinobu Fujiwara; Markus Landthaler; Tohru Natsume; Shungo Adachi; Shintaro Iwasaki; Osamu Takeuchi

  EMBO Reports, 05 Nov. 2019, Peer-reviewed

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• Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs

  Takashi Mino; Noriki Iwai; Masayuki Endo; Kentaro Inoue; Kotaro Akaki; Fabian Hia; Takuya Uehata; Tomoko Emura; Kumi Hidaka; Yutaka Suzuki; Daron M. Standley; Mariko Okada-Hatakeyama; Shigeo Ohno; Hiroshi Sugiyama; Akio Yamashita; Osamu Takeuchi

  Nucleic acids research, 19 Sep. 2019, Peer-reviewed

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• NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements

  Shigeki Hirabayashi; Shruti Bhagat; Yu Matsuki; Yujiro Takegami; Takuya Uehata; Ai Kanemaru; Masayoshi Itoh; Kotaro Shirakawa; Akifumi Takaori-Kondo; Osamu Takeuchi; Piero Carninci; Shintaro Katayama; Yoshihide Hayashizaki; Juha Kere; Hideya Kawaji; Yasuhiro Murakawa

  Nature Genetics, 01 Sep. 2019, Peer-reviewed

  
• N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation

  Daichi Yamasoba; Kei Sato; Takuya Ichinose; Tomoko Imamura; Lennart Koepke; Simone Joas; Elisabeth Reith; Dominik Hotter; Naoko Misawa; Kotaro Akaki; Takuya Uehata; Takashi Mino; Sho Miyamoto; Takeshi Noda; Akio Yamashita; Daron M. Standley; Frank Kirchhoff; Daniel Sauter; Yoshio Koyanagi; Osamu Takeuchi

  Nature Microbiology, 01 Sep. 2019, Peer-reviewed

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• RNA binding proteins in the control of autoimmune diseases.

  Masanori Yoshinaga; Osamu Takeuchi

  Immunological medicine, Jun. 2019

  
• Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

  Jianwei Wang; Miho Sekai; Takeshi Matsui; Yosuke Fujii; Mitsuru Matsumoto; Osamu Takeuchi; Nagahiro Minato; Yoko Hamazaki

  International Immunology, 05 Mar. 2019, Peer-reviewed

  
• Post-transcriptional control of immune responses and its potential application.

  Masanori Yoshinaga; Osamu Takeuchi

  Clinical & translational immunology, 2019

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• インターフェロンのインパクト MALT1によるN4BP1の分解は潜伏感染HIV-1の再活性化を促進する

  山岨 大智; 佐藤 佳; 小柳 義夫; 竹内 理

  日本エイズ学会誌, Nov. 2018

  
• Translation of hepatitis A virus IRES is upregulated by a hepatic cell-specific factor

  Akitoshi Sadahiro; Akira Fukao; Mio Kosaka; Yoshinori Funakami; Naoki Takizawa; Osamu Takeuchi; Kent E. Duncan; Toshinobu Fujiwara

  Frontiers in Genetics, 10 Aug. 2018, Peer-reviewed

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• Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia article

  Yoshinari Nakatsuka; Alexis Vandenbon; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Xiaotong Cui; Ayuko Sato; Tohru Tsujimura; Yutaka Suzuki; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Teiji Sawa; Toyohiro Hirai; Osamu Takeuchi

  Mucosal Immunology, 01 Jul. 2018, Peer-reviewed

  
• 【がんは免疫系をいかに抑制するのか 免疫チェックポイント阻害剤の真の標的を求めて】TAM・MDSCによる免疫抑制機構

  吉永 正憲; 竹内 理

  実験医学, Jun. 2018, Peer-reviewed

  
• 生化学・分子生物学 RNA分解酵素Regnase-1による鉄代謝制御

  吉永 正憲; 竹内 理

  医学のあゆみ, Apr. 2018, Peer-reviewed

  
• RNA-mediated mechanisms to regulate viral infection and gene expression in the innate immune system

  Takuya Uehata; Osamu Takeuchi

  Seikagaku, 2018, Peer-reviewed

  
• Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond

  Osamu Takeuchi

  Wiley Interdisciplinary Reviews: RNA, 2018, Peer-reviewed

  
• Post-transcriptional regulation of immune responses by RNA binding proteins

  Takashi Mino; Osamu Takeuchi

  Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 2018, Peer-reviewed

  
• Regnase-1 and roquin nonredundantly regulate Th1 differentiation causing cardiac inflammation and fibrosis

  Xiaotong Cui; Takashi Mino; Masanori Yoshinaga; Yoshinari Nakatsuka; Fabian Hia; Daichi Yamasoba; Tohru Tsujimura; Keizo Tomonaga; Yutaka Suzuki; Takuya Uehata; Osamu Takeuchi

  Journal of Immunology, 15 Dec. 2017, Peer-reviewed

  
• NSD3 keeps IRF3 active

  Takashi Mino; Osamu Takeuchi

  Journal of Experimental Medicine, 01 Dec. 2017, Peer-reviewed

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• Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs

  Masanori Yoshinaga; Yoshinari Nakatsuka; Alexis Vandenbon; Daisuke Ori; Takuya Uehata; Tohru Tsujimura; Yutaka Suzuki; Takashi Mino; Osamu Takeuchi

  Cell Reports, 23 May 2017, Peer-reviewed

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• Regnase-1 is an endoribonuclease essential for the maintenance of immune homeostasis

  Takuya Uehata; Osamu Takeuchi

  Journal of Interferon and Cytokine Research, May 2017, Peer-reviewed

  
• Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response

  Tatsuya Kozaki; Jun Komano; Daiki Kanbayashi; Michihiro Takahama; Takuma Misawa; Takashi Satoh; Osamu Takeuchi; Taro Kawai; Shigeomi Shimizu; Yoshiharu Matsuura; Shizuo Akira; Tatsuya Saitoh

  Proceedings of the National Academy of Sciences of the United States of America, 07 Mar. 2017, Peer-reviewed

  
• Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

  Sarang Tartey; Osamu Takeuchi

  International Reviews of Immunology, 04 Mar. 2017, Peer-reviewed

  
• Translational control of mRNAs by 3'-Untranslated region binding proteins

  Akio Yamashita; Osamu Takeuchi

  BMB Reports, 2017, Peer-reviewed

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• 【慢性炎症性疾患の新たな展開】慢性炎症のメカニズム 慢性炎症における炎症性サイトカインの新たな制御機構

  吉永 正憲; 竹内 理

  最新医学, Nov. 2016, Peer-reviewed

  
• 【マクロファージのすべて】基礎 炎症性サイトカインIL-6とその転写後調節

  吉永 正憲; 竹内 理

  医学のあゆみ, Oct. 2016, Peer-reviewed

  
• Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

  Katsuaki Hoshino; Osamu Takeuchi; Taro Kawai; Hideki Sanjo; Tomohiko Ogawa; Yoshifumi Takeda; Kiyoshi Takeda; Shizuo Akira

  JOURNAL OF IMMUNOLOGY, Oct. 2016, Peer-reviewed

  
• Cutting Edge: Toll-like receptor 4 (TLR4)-Deficient Mice Are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product

  Katsuaki Hoshino; Osamu Takeuchi; Taro Kawai; Hideki Sanjo; Tomohiko Ogawa; Yoshifumi Takeda; Kiyoshi Takeda; Shizuo Akira

  Journal of Immunology, 01 Oct. 2016, Peer-reviewed

  
• Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

  Ayako Ishikita; Tetsuya Matoba; Gentaro Ikeda; Jun Ichiro Koga; Yajing Mao; Kaku Nakano; Osamu Takeuchi; Junichi Sadoshima; Kensuke Egashira

  Journal of the American Heart Association, 22 Jul. 2016, Peer-reviewed

  
• Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA

  Masuda, K; Ripley, B; Nyati, K; Dubey, P; Zaman, M; Hanieh, H; Hoga, M; Yamashita, K; Standley, D; Mashima, T; Katahira, M; Okamoto, T; Matsuura, Y; Takeuchi, O; Kishimoto, T

  The Journal of experimental medicine, 04 Apr. 2016, Peer-reviewed

  
• Arid5a regulates naive CD4⁺ T cell fate through selective stabilization of Stat3 mRNA

  Kazuya Masuda; Barry Ripley; Kishan Kumar Nyati; Praveen Kumar Dubey; Mohammad Mahabub Uz Zaman; Hamza Hanieh; Mitsuru Higa; Kazuo Yamashita; Daron M. Standley; Tsukasa Mashima; Masato Katahira; Toru Okamoto; Yoshiharu Matsuura; Osamu Takeuchi; Tadamitsu Kishimoto

  Journal of Experimental Medicine, Apr. 2016, Peer-reviewed

  
• Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

  Mikaël M. Martino; Kenta Maruyama; Gisela A. Kuhn; Takashi Satoh; Osamu Takeuchi; Ralph Müller; Shizuo Akira

  Nature Communications, 22 Mar. 2016, Peer-reviewed

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• Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions

  Mariko Yokogawa; Takashi Tsushima; Nobuo N. Noda; Hiroyuki Kumeta; Yoshiaki Enokizono; Kazuo Yamashita; Daron M. Standley; Osamu Takeuchi; Shizuo Akira; Fuyuhiko Inagaki

  Scientific Reports, 01 Mar. 2016, Peer-reviewed

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• Akirin2-mediated transcriptional control by recruiting SWI/SNF complex in B cells

  Sarang Tartey; Osamu Takeuchi

  Critical Reviews in Immunology, 2016, Peer-reviewed

  
• Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin

  Takashi Mino; Osamu Takeuchi

  Folia Pharmacologica Japonica, 2016, Peer-reviewed

  
• 炎症制御の分子機構

  吉永 正憲; 竹内 理

  臨床免疫・アレルギー科, Oct. 2015, Peer-reviewed

  
• Chromatin remodeling and transcriptional control in innate immunity: Emergence of Akirin2 as a novel player

  Sarang Tartey; Osamu Takeuchi

  Biomolecules, 22 Jul. 2015, Peer-reviewed

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• Essential function for the nuclear protein akirin2 in B cell activation and humoral immune responses

  Sarang Tartey; Kazufumi Matsushita; Tomoko Imamura; Atsuko Wakabayashi; Daisuke Ori; Takashi Mino; Osamu Takeuchi

  Journal of Immunology, 15 Jul. 2015, Peer-reviewed

  
• Regnase-1 and roquin regulate a common element in inflammatory mRNAs by spatiotemporally distinct mechanisms

  Takashi Mino; Yasuhiro Murakawa; Akira Fukao; Alexis Vandenbon; Hans Hermann Wessels; Daisuke Ori; Takuya Uehata; Sarang Tartey; Shizuo Akira; Yutaka Suzuki; Carola G. Vinuesa; Uwe Ohler; Daron M. Standley; Markus Landthaler; Toshinobu Fujiwara; Osamu Takeuchi

  Cell, 30 May 2015, Peer-reviewed

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• A lipopolysaccharide from pantoea agglomerans is a promising adjuvant for sublingual vaccines to induce systemic and mucosal immune responses in Mice via TLR4 pathway

  Masahiro Fukasaka; Daisuke Asari; Eiji Kiyotoh; Arimichi Okazaki; Yasuyuki Gomi; Takeshi Tanimoto; Osamu Takeuchi; Shizuo Akira; Mitsuhiko Hori

  PLoS ONE, 15 May 2015, Peer-reviewed

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• HuR keeps interferon-β mRNA stable

  Osamu Takeuchi

  European Journal of Immunology, 01 May 2015, Peer-reviewed

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• 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival

  Kenta Maruyama; Masahiro Fukasaka; Satoshi Uematsu; Osamu Takeuchi; Takeshi Kondo; Tatsuya Saitoh; Mikaël M. Martino; Shizuo Akira

  Journal of Biological Chemistry, Apr. 2015, Peer-reviewed

  
• Nickel ions selectively inhibit lipopolysaccharide-inducedinterleukin-6 production by decreasing its mRNA stability

  Sanki Asakawa; Yu Kishimoto; Takayuki Takano; Kiyuki Okita; Shiho Takakuwa; Taiki Sato; Masahiro Hiratsuka; Osamu Takeuchi; Noriyasu Hirasawa

  PLoS ONE, 05 Mar. 2015, Peer-reviewed

  
• Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

  Meghana N. Patel; William G. Bernard; Nikolay B. Milev; William P. Cawthorn; Nichola Figg; Dan Hart; Xavier Prieur; Sam Virtue; Krisztina Hegyi; Stephanie Bonnafous; Beatrice Bailly-Maitre; Yajing Chuf; Julian L. Griffinf; Ziad Mallat; Robert V. Considineh; Albert Tranc; Philippe Gual; Osamu Takeuchi; Shizuo Akira; Antonio Vidal-Pui; Martin R. Bennett; Jaswinder K. Sethi

  Proceedings of the National Academy of Sciences of the United States of America, 13 Jan. 2015, Peer-reviewed

  
• Regnase-1 and Roquin regulate inflammatory mRNAs

  Takashi Mino; Osamu Takeuchi

  Oncotarget, 2015, Peer-reviewed

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• Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by arf-like protein 5B

  Yuichi Kitai; Osamu Takeuchi; Takumi Kawasaki; Daisuke Ori; Takuya Sueyoshi; Motoya Murase; Shizuo Akira; Taro Kawai

  Journal of Biological Chemistry, 01 Jan. 2015, Peer-reviewed

  
• Posttranscriptional control of inflammation by an RNase regnase-1

  Osamu Takeuchi

  Folia Pharmacologica Japonica, 2015, Peer-reviewed

  
• Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex

  Sarang Tartey; Kazufumi Matsushita; Alexis Vandenbon; Daisuke Ori; Tomoko Imamura; Takashi Mino; Daron M. Standley; Jules A. Hoffmann; Jean Marc Reichhart; Shizuo Akira; Osamu Takeuchi

  EMBO Journal, 16 Oct. 2014, Peer-reviewed

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• Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

  François Bonnay; Xuan Hung Nguyen; Eva Cohen-Berros; Laurent Troxler; Eric Batsche; Jacques Camonis; Osamu Takeuchi; Jean Marc Reichhart; Nicolas Matt

  EMBO Journal, 16 Oct. 2014, Peer-reviewed

  
• [Innate immunity]

  Osamu Takeuchi

  [Rinshō ketsueki] The Japanese journal of clinical hematology, 01 Oct. 2014, Peer-reviewed

  
• Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity

  Kanako Kuniyoshi; Osamu Takeuchi; Surya Pandey; Takashi Satoh; Hidenori Iwasaki; Shizuo Akira; Taro Kawai

  Proceedings of the National Academy of Sciences of the United States of America, Apr. 2014, Peer-reviewed

  
• Toll-Like Receptors: Role in Inflammation and Cancer

  Sarang Tartey; Osamu Takeuchi

  Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects, 31 Mar. 2014, Peer-reviewed

  
• Nucleic acid sensing by T cells initiates Th2 cell differentiation

  Takayuki Imanishi; Chitose Ishihara; Mohamed E.l.Sherif G.adelhaq Badr; Akiko Hashimoto-Tane; Yayoi Kimura; Taro Kawai; Osamu Takeuchi; Ken J. Ishii; Shun'ichiro Taniguchi; Tetsuo Noda; Hisashi Hirano; Frank Brombacher; Glen N. Barber; Shizuo Akira; Takashi Saito

  Nature communications, 2014, Peer-reviewed

  
• Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation

  Alexis Vandenbon; Shunsuke Teraguchi; Osamu Takeuchi; Yutaka Suzuki; Daron M. Standley

  BMC Genomics, 2014, Peer-reviewed

  
• Bases for time-resolved probing of transient carrier dynamics by optical pump-probe scanning tunneling microscopy.

  Munenori Yokota; Shoji Yoshida; Yutaka Mera; Osamu Takeuchi; Haruhiro Oigawa; Hidemi Shigekawa

  Nanoscale, 07 Oct. 2013, Peer-reviewed

  
• The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation

  Jianhui Ma; Bo Ram Bang; Jiawei Lu; So Young Eun; Motoyuki Otsuka; Michael Croft; Peter Tobias; Jiahuai Han; Osamu Takeuchi; Shizuo Akira; Michael Karin; Hideo Yagita; Young Jun Kang

  Science Signaling, 01 Oct. 2013, Peer-reviewed

  
• Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.

  Lee H; Komano J; Saitoh Y; Yamaoka S; Kozaki T; Misawa T; Takahama M; Satoh T; Takeuchi O; Yamamoto N; Matsuura Y; Saitoh T; Akira S

  Proc Natl Acad Sci U S A, Jul. 2013

  
• Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β

  Tadaomi Kawashima; Akemi Kosaka; Huimin Yan; Zijin Guo; Ryosuke Uchiyama; Ryutaro Fukui; Daisuke Kaneko; Yutaro Kumagai; Dong Ju You; Joaquim Carreras; Satoshi Uematsu; Myoung Ho Jang; Osamu Takeuchi; Tsuneyasu Kaisho; Shizuo Akira; Kensuke Miyake; Hiroko Tsutsui; Takashi Saito; Ikuko Nishimura; Noriko M. Tsuji

  Immunity, 27 Jun. 2013, Peer-reviewed

  
• Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation

  Masahiro Fukasaka; Daisuke Ori; Tatsukata Kawagoe; Satoshi Uematsu; Kenta Maruyama; Toshihiko Okazaki; Tatsuya Kozaki; Tomoko Imamura; Sarang Tartey; Takashi Mino; Takashi Satoh; Shizuo Akira; Osamu Takeuchi

  Journal of Immunology, 01 Jun. 2013, Peer-reviewed

  
• XMalt1-induced cleavage of regnase-1 in CD4⁺ helper T cells regulates immune activation

  Takuya Uehata; Hidenori Iwasaki; Alexis Vandenbon; Kazufumi Matsushita; Eduardo Hernandez-Cuellar; Kanako Kuniyoshi; Takashi Satoh; Takashi Mino; Yutaka Suzuki; Daron M. Standley; Tohru Tsujimura; Hiromi Rakugi; Yoshitaka Isaka; Osamu Takeuchi; Shizuo Akira

  Cell, 23 May 2013, Peer-reviewed

  
• IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation

  Hilary Sandig; Catherine E. Jobbings; Nestor Gonzalez Roldan; Jayde K. Whittingham-Dowd; Zane Orinska; Osamu Takeuchi; Shizuo Akira; Silvia Bulfone-Paus

  European Journal of Immunology, Apr. 2013, Peer-reviewed

  
• Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs

  Daisuke Ori; Hiroki Kato; Hideki Sanjo; Sarang Tartey; Takashi Mino; Shizuo Akira; Osamu Takeuchi

  Journal of Immunology, Apr. 2013, Peer-reviewed

  
• Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

  Takashi Satoh; Hiroyasu Kidoya; Hisamichi Naito; Masahiro Yamamoto; Naoki Takemura; Katsuhiro Nakagawa; Yoshichika Yoshioka; Eiichi Morii; Nobuyuki Takakura; Osamu Takeuchi; Shizuo Akira

  Nature, 28 Mar. 2013, Peer-reviewed

  
• Toll-Like Receptors

  H. Kumar; O. Takeuchi; S. Akira

  Encyclopedia of Biological Chemistry: Second Edition, 15 Feb. 2013, Peer-reviewed

  
• Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP

  Kenta Maruyama; Satoshi Uematsu; Takeshi Kondo; Osamu Takeuchi; Mikaël M. Martino; Takumi Kawasaki; Shizuo Akira

  Journal of Experimental Medicine, 2013, Peer-reviewed

  
• Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation

  Takashi Mino; Osamu Takeuchi

  Biotechnology and Genetic Engineering Reviews, 2013, Peer-reviewed

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• The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation

  Kenta Maruyama; Masahiro Fukasaka; Alexis Vandenbon; Tatsuya Saitoh; Takumi Kawasaki; Takeshi Kondo; Kazunari K. Yokoyama; Hiroyasu Kidoya; Nobuyuki Takakura; Daron Standley; Osamu Takeuchi; Shizuo Akira

  Immunity, 14 Dec. 2012, Peer-reviewed

  
• Post-transcriptional regulation controls the initiation and resolution of innate immune response

  三野享史; 竹内理

  医学のあゆみ, 06 Oct. 2012, Peer-reviewed

  
• TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation

  Kenta Maruyama; Tatsukata Kawagoe; Takeshi Kondo; Shizuo Akira; Osamu Takeuchi

  Journal of Biological Chemistry, 17 Aug. 2012, Peer-reviewed

  
• IRF3: A molecular switch in pathogen responses

  Osamu Takeuchi

  Nature Immunology, Jul. 2012, Peer-reviewed

  
• CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan

  Takayuki Abe; Takasuke Fukuhara; Xiauyu Wen; Akinori Ninomiya; Kohji Moriishi; Yoshihiko Maehara; Osamu Takeuchi; Taro Kawai; Shizuo Akira; Yoshiharu Matsuura

  Journal of Virology, Jun. 2012, Peer-reviewed

  
• West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

  Andrea Schuessler; Anneke Funk; Helen M. Lazear; Daphne A. Cooper; Shessy Torres; Stephane Daffis; Babal Kant Jha; Yutaro Kumagai; Osamu Takeuchi; Paul Hertzog; Robert Silverman; Shizuo Akira; David J. Barton; Michael S. Diamond; Alexander A. Khromykh

  Journal of Virology, May 2012, Peer-reviewed

  
• NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA

  Sachin D. Deshmukh; Sabrina Müller; Katrin Hese; Katharina S. Rauch; Julia Wennekamp; Osamu Takeuchi; Shizuo Akira; Douglas T. Golenbock; Philipp Henneke

  Journal of Immunology, 15 Jan. 2012, Peer-reviewed

  
• Contribution of LGP2 to Viral Recognition Pathways

  Takeuchi, O.; Akira, S.

  Nucleic Acid Sensors and Antiviral Immunity, 2012, Peer-reviewed

  
• 自然免疫Update 一研究最前線( 企画)

  竹内理

  医学のあゆみ,243,2012, 2012, Peer-reviewed

  
• IkBキナーゼによるRegnase-1 の調節

  竹内理

  感染炎症免疫、42、57-59, 2012, 2012, Peer-reviewed

  
• RNA と自然免疫

  竹内理

  免疫学Update, 第3 章,2012, 2012, Peer-reviewed

  
• The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice

  Yuko Abe; Ken Fujii; Noriyo Nagata; Osamu Takeuchi; Shizuo Akira; Hiroyuki Oshiumi; Misako Matsumoto; Tsukasa Seya; Satoshi Koike

  Journal of Virology, Jan. 2012, Peer-reviewed

  
• The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1

  Hidenori Iwasaki; Osamu Takeuchi; Shunsuke Teraguchi; Kazufumi Matsushita; Takuya Uehata; Kanako Kuniyoshi; Takashi Satoh; Tatsuya Saitoh; Mutsuyoshi Matsushita; Daron M. Standley; Shizuo Akira

  Nature Immunology, Dec. 2011, Peer-reviewed

  
• Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice

  Koichiro Matsumoto; Keiko Kan-o; Miyuki Eguchi-Tsuda; Satoru Fukuyama; Yukari Asai; Takafumi Matsumoto; Atsushi Moriwaki; Yuko Matsunaga; Hiroko Tsutsui; Taro Kawai; Osamu Takeuchi; Shizuo Akira; Hideo Yagita; Miyuki Azuma; Yoichi Nakanishi; Hiromasa Inoue

  American Journal of Respiratory Cell and Molecular Biology, 01 Jul. 2011, Peer-reviewed

  
• Antiviral protein viperin promotes toll-like receptor 7- and toll-like receptor 9-mediated type i interferon production in plasmacytoid dendritic cells

  Tatsuya Saitoh; Takashi Satoh; Naoki Yamamoto; Satoshi Uematsu; Osamu Takeuchi; Taro Kawai; Shizuo Akira

  Immunity, 25 Mar. 2011, Peer-reviewed

  
• IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil

  Pui Y. Lee; Yutaro Kumagai; Yuan Xu; Yi Li; Tolga Barker; Chao Liu; Eric S. Sobel; Osamu Takeuchi; Shizuo Akira; Minoru Satoh; Westley H. Reeves

  Journal of Immunology, 01 Feb. 2011, Peer-reviewed

  
• Akt contributes to activation of the TRIF-dependent signaling pathways of TLRS by interacting with TANK-binding kinase 1

  Sun Myung Joung; Zee Yong Park; Shilpa Rani; Osamu Takeuchi; Shizuo Akira; Joo Young Lee

  Journal of Immunology, 01 Jan. 2011, Peer-reviewed

  
• BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

  Decheng Ren; Ho Chou Tu; Hyungjin Kim; Gary X. Wang; Gregory R. Bean; Osamu Takeuchi; John R. Jeffers; Gerard P. Zambetti; James J.D. Hsieh; Emily H.Y. Cheng

  Science, 03 Dec. 2010, Peer-reviewed

  
• Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling

  Shuhei Hashiguchi; Yuya Yamaguchi; Osamu Takeuchi; Shizuo Akira; Kazuhisa Sugimura

  Biochemical and Biophysical Research Communications, 05 Nov. 2010, Peer-reviewed

  
• Negative regulators in toll-like receptor responses

  Shizuo Akira; Tatsuya Saitoh; Kazufumi Matsushita; Osamu Takeuchi

  Cornea, Nov. 2010, Peer-reviewed

  
• The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

  Takashi Satoh; Osamu Takeuchi; Alexis Vandenbon; Koubun Yasuda; Yoshiaki Tanaka; Yutaro Kumagai; Tohru Miyake; Kazufumi Matsushita; Toshihiko Okazaki; Tatsuya Saitoh; Kiri Honma; Toshifumi Matsuyama; Katsuyuki Yui; Tohru Tsujimura; Daron M. Standley; Kenji Nakanishi; Kenta Nakai; Shizuo Akira

  Nature Immunology, Oct. 2010, Peer-reviewed

  
• Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity

  Oliver Schulz; Andreas Pichlmair; Jan Rehwinkel; Neil C. Rogers; Donalyn Scheuner; Hiroki Kato; Osamu Takeuchi; Shizuo Akira; Randal J. Kaufman; Caetano Reis E Sousa

  Cell Host and Microbe, 20 May 2010, Peer-reviewed

  
• Human lactoferrin activates NF-κB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

  Ken Ando; Keiichi Hasegawa; Ken Ichi Shindo; Tomoyasu Furusawa; Tomofumi Fujino; Kiyomi Kikugawa; Hiroyasu Nakano; Osamu Takeuchi; Shizuo Akira; Taishin Akiyama; Jin Gohda; Jun Ichiro Inoue; Makio Hayakawa

  FEBS Journal, May 2010, Peer-reviewed

  
• 自然免疫における臨床展望

  三宅 亨; 竹内 理; 審良 静男

  Medical Practice, May 2010

  
• Pattern Recognition Receptors and Inflammation

  Osamu Takeuchi; Shizuo Akira

  Cell, Mar. 2010, Peer-reviewed

  
• Regulation of immune responses by mRNA stability control

  Osamu Takeuchi

  Seikagaku, 2010, Peer-reviewed

  
• Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction

  Hiroyuki Oshiumi; Masanori Ikeda; Misako Matsumoto; Ayako Watanabe; Osamu Takeuchi; Shizuo Akira; Nobuyuki Kato; Kunitada Shimotohno; Tsukasa Seya

  PLoS ONE, 2010, Peer-reviewed

  
• An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

  Michael Berger; Philippe Krebs; Karine Crozat; Xiaohong Li; Ben A. Croker; Owen M. Siggs; Daniel Popkin; Xin Du; Brian R. Lawson; Argyrios N. Theofilopoulos; Yu Xia; Kevin Khovananth; Eva Marie Y. Moresco; Takashi Satoh; Osamu Takeuchi; Shizuo Akira; Bruce Beutler

  Nature Immunology, 2010, Peer-reviewed

  
• P53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

  David G. Kirsch; Philip M. Santiago; Emmanuelle Di Tomaso; Julie M. Sullivan; Wu Shiun Hou; Talya Dayton; Laura B. Jeffords; Pooja Sodha; Kim L. Mercer; Rhianna Cohen; Osamu Takeuchi; Stanley J. Korsmeyer; Roderick T. Bronson; Carla F. Kim; Kevin M. Haigis; Rakesh K. Jain; Tyler Jacks

  Science, 2010, Peer-reviewed

  
• Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

  Eri Ishikawa; Tetsuaki Ishikawa; Yasu S. Morita; Kenji Toyonaga; Hisakata Yamada; Osamu Takeuchi; Taroh Kinoshita; Shizuo Akira; Yasunobu Yoshikai; Sho Yamasaki

  Journal of Experimental Medicine, 21 Dec. 2009, Peer-reviewed

  
• Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

  Hyungjin Kim; Ho Chou Tu; Decheng Ren; Osamu Takeuchi; John R. Jeffers; Gerard P. Zambetti; James J.D. Hsieh; Emily H.Y. Cheng

  Molecular Cell, 13 Nov. 2009, Peer-reviewed

  
• Control of inflammatory responses by a novel RNase, Zc3h12a

  Osamu Takeuchi; Kazufumi Matsushita; Shizuo Akira

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Nov. 2009, Peer-reviewed

  
• Activation of MDA5 requires higher-order RNA structures generated during virus infection

  Andreas Pichlmair; Oliver Schulz; Choon Ping Tan; Jan Rehwinkel; Hiroki Kato; Osamu Takeuchi; Shizuo Akira; Michael Way; Giampietro Schiavo; Caetano Reis E Sousa

  Journal of Virology, Oct. 2009, Peer-reviewed

  
• Poly I:C-induced activation of NK cells by CD8α⁺ dendritic cells via the IPS-1 and TRIF-dependent pathways

  Tohru Miyake; Yutaro Kumagai; Hiroki Kato; Zijin Guo; Kazufumi Matsushita; Takashi Satoh; Tatsukata Kawagoe; Himanshu Kumar; Myoung Ho Jang; Taro Kawai; Tohru Tani; Osamu Takeuchi; Shizuo Akira

  Journal of Immunology, 15 Aug. 2009, Peer-reviewed

  
• Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner

  Takayuki Abe; Yuuki Kaname; Xiaoyu Wen; Hideki Tani; Kohji Moriishi; Satoshi Uematsu; Osamu Takeuchi; Ken J. Ishii; Taro Kawai; Shizuo Akira; Yoshiharu Matsuura

  Journal of Virology, Aug. 2009, Peer-reviewed

  
• Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

  Martin Schlee; Andreas Roth; Veit Hornung; Cristina Amparo Hagmann; Vera Wimmenauer; Winfried Barchet; Christoph Coch; Markus Janke; Aleksandra Mihailovic; Greg Wardle; Stefan Juranek; Hiroki Kato; Taro Kawai; Hendrik Poeck; Katherine A. Fitzgerald; Osamu Takeuchi; Shizuo Akira; Thomas Tuschl; Eicke Latz; Janos Ludwig; Gunther Hartmann

  Immunity, 17 Jul. 2009, Peer-reviewed

  
• TRAF6 establishes innate immune responses by activating NF-κB and IRF7 upon sensing cytosolic viral RNA and DNA

  Hiroyasu Konno; Takuya Yamamoto; Kohsuke Yamazaki; Jin Gohda; Taishin Akiyama; Kentaro Semba; Hideo Goto; Atsushi Kato; Toshiaki Yujiri; Takahiko Imai; Yasushi Kawaguchi; Bing Su; Osamu Takeuchi; Shizuo Akira; Yasuko Tsunetsugu-Yokota; Jun Ichiro Inoue

  PLoS ONE, 25 May 2009, Peer-reviewed

  
• Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

  Kazufumi Matsushita; Osamu Takeuchi; Daron M. Standley; Yutaro Kumagai; Tatsukata Kawagoe; Tohru Miyake; Takashi Satoh; Hiroki Kato; Tohru Tsujimura; Haruki Nakamura; Shizuo Akira

  Nature, Apr. 2009, Peer-reviewed

  
• Cutting edge: TLR-dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-α production in plasmacytoid dendritic cells

  Yutaro Kumagai; Himanshu Kumar; Shohei Koyama; Taro Kawai; Osamu Takeuchi; Shizuo Akira

  Journal of Immunology, Apr. 2009, Peer-reviewed

  
• The triacylated ATP binding cluster transporter substrate-binding lipoprotein of Staphylococcus aureus functions as a native ligand for toll-like receptor 2

  Kenji Kurokawa; Hanna Lee; Kyung Baeg Roh; Miwako Asanuma; Young Sook Kim; Hiroshi Nakayama; Akiko Shiratsuchi; Youngnim Choi; Osamu Takeuchi; Hee Jung Kang; Naoshi Dohmae; Yoshinobu Nakanishi; Shizuo Akira; Kazuhisa Sekimizu; Bok Luel Lee

  Journal of Biological Chemistry, 27 Mar. 2009, Peer-reviewed

  
• Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

  Desiree A. Steimer; Kelli Boyd; Osamu Takeuchi; Jill K. Fisher; Gerard P. Zambetti; Joseph T. Opferman

  Blood, 19 Mar. 2009, Peer-reviewed

  
• TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

  Tatsukata Kawagoe; Osamu Takeuchi; Yoshitsugu Takabatake; Hiroki Kato; Yoshitaka Isaka; Tohru Tsujimura; Shizuo Akira

  Nature Immunology, 2009, Peer-reviewed

  
• Innate immunity to virus infection

  Osamu Takeuchi; Shizuo Akira

  Immunological Reviews, Jan. 2009, Peer-reviewed

  
• TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

  Pui Y. Lee; Yutaro Kumagai; Yi Li; Osamu Takeuchi; Hideo Yoshida; Jason Weinstein; Erinn S. Kellner; Dina Nacionales; Tolga Barker; Kindra Kelly-Scumpia; Nico Van Rooijen; Himanshu Kumar; Taro Kawai; Minoru Satoh; Shizuo Akira; Westley H. Reeves

  Journal of Experimental Medicine, 22 Dec. 2008, Peer-reviewed

  
• Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

  Tatsuya Saitoh; Naonobu Fujita; Myoung Ho Jang; Satoshi Uematsu; Bo Gie Yang; Takashi Satoh; Hiroko Omori; Takeshi Noda; Naoki Yamamoto; Masaaki Komatsu; Keiji Tanaka; Taro Kawai; Tohru Tsujimura; Osamu Takeuchi; Tamotsu Yoshimori; Shizuo Akira

  Nature, 13 Nov. 2008, Peer-reviewed

  
• Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

  Hiroki Kato; Osamu Takeuchi; Eriko Mikamo-Satoh; Reiko Hirai; Tomoji Kawai; Kazufumi Matsushita; Akane Hiiragi; Terence S. Dermody; Takashi Fujita; Shizuo Akira

  Journal of Experimental Medicine, 07 Jul. 2008, Peer-reviewed

  
• A patient with adenocarcinoma of the jejunum successfully diagnosed by preoperative endoscopy for the small intestine

  Yuji Sakai; Toshio Tsuyuguchi; Tadashi Ohara; Seigo Yukisawa; Shin Tsuchiya; Harutoshi Sugiyama; Kaoru Miyakawa; Masamichi Ohbu; Kazuki Kato; Michio Kimura; Takashi Kaiho; Osamu Takeuchi; Osamu Matsuzaki; Masaru Miyazaki; Osamu Yokosuka

  HEPATO-GASTROENTEROLOGY, Jul. 2008, Peer-reviewed

  
• Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

  Tatsukata Kawagoe; Shintaro Sato; Kazufumi Matsushita; Hiroki Kato; Kosuke Matsui; Yutaro Kumagai; Tatsuya Saitoh; Taro Kawai; Osamu Takeuchi; Shizuo Akira

  Nature Immunology, Jun. 2008, Peer-reviewed

  
• Pathogen recognition by innate receptors

  Yutaro Kumagai; Osamu Takeuchi; Shizuo Akira

  Journal of Infection and Chemotherapy, Apr. 2008, Peer-reviewed

  
• TLR9 as a key receptor for the recognition of DNA

  Yutaro Kumagai; Osamu Takeuchi; Shizuo Akira

  Advanced Drug Delivery Reviews, Apr. 2008, Peer-reviewed

  
• TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

  Ken J. Ishii; Tatsukata Kawagoe; Shohei Koyama; Kosuke Matsui; Himanshu Kumar; Taro Kawai; Satoshi Uematsu; Osamu Takeuchi; Fumihiko Takeshita; Cevayir Coban; Shizuo Akira

  Nature, 07 Feb. 2008, Peer-reviewed

  
• MDA5/RIG-I and virus recognition

  Osamu Takeuchi; Shizuo Akira

  Current Opinion in Immunology, Feb. 2008, Peer-reviewed

  
• Corrigendum: Akirins are highly conserved nuclear proteins required for NF-kappa B-dependent gene expression in drosophila and mice (vol 9, pg 97, 2008)

  Akira Goto; Kazufumi Matsushita; Viola Gesellchen; Laure El Chamy; David Kuttenkeuler; Osamu Takeuchi; Jules A. Hoffmann; Shizuo Akira; Michael Boutros; Jean-Marc Reichhart

  NATURE IMMUNOLOGY, Feb. 2008, Peer-reviewed

  
• Erratum: Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice (Nature Immunology (2008) vol. 9 (97-104)

  Akira Goto; Kazufumi Matsushita; Viola Gesellchen; Laure El Chamy; David Kuttenkeuler; Osamu Takeuchi; Jules A. Hoffmann; Shizuo Akira; Michael Boutros; Jean Marc Reichhart

  Nature Immunology, Feb. 2008, Peer-reviewed

  
• Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling

  Rabindra N. Bhattacharjee; Kwon Sam Park; Xiuhao Chen; Tetsuya Iida; Takeshi Honda; Osamu Takeuchi; Shizuo Akira

  Journal of Microbiology and Biotechnology, 28 Jan. 2008, Peer-reviewed

  
• RIG-I-like antiviral protein in flies

  Osamu Takeuchi; Shizuo Akira

  Nature Immunology, 2008, Peer-reviewed

  
• Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice

  Akira Goto; Kazufumi Matsushita; Viola Gesellchen; Laure El Chamy; David Kuttenkeuler; Osamu Takeuchi; Jules A. Hoffmann; Shizuo Akira; Michael Boutros; Jean Marc Reichhart

  Nature Immunology, Jan. 2008, Peer-reviewed

  
• Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88

  Andreas Jung; Hiroki Kato; Yutaro Kumagai; Himanshu Kumar; Taro Kawai; Osamu Takeuchi; Shizuo Akira

  Journal of Virology, Jan. 2008, Peer-reviewed

  
• Recognition of virus invasion by toll-like receptors and RIG-Ilike helicases

  Hiroki Kato; Osamu Takeuchi

  Nucleic Acids in Innate Immunity, 01 Jan. 2008, Peer-reviewed

  
• Recognition of viruses by innate immunity

  Osamu Takeuchi; Shizuo Akira

  Immunological Reviews, Dec. 2007, Peer-reviewed

  
• Genetic analysis of resistance to viral infection

  Bruce Beutler; Celine Eidenschenk; Karine Crozat; Jean Luc Imler; Osamu Takeuchi; Jules A. Hoffmann; Shizuo Akira

  Nature Reviews Immunology, Oct. 2007, Peer-reviewed

  
• Enhanced TLR-mediated NF-IL6-dependent gene expression by Trib1 deficiency

  Masahiro Yamamoto; Satoshi Uematsu; Toru Okamoto; Yoshiharu Matsuura; Shintaro Sato; Himanshu Kumar; Takashi Satoh; Tatsuya Saitoh; Kiyoshi Takeda; Ken J. Ishii; Osamu Takeuchi; Taro Kawai; Shizuo Akira

  Journal of Experimental Medicine, 03 Sep. 2007, Peer-reviewed

  
• Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

  Takayuki Abe; Yuuki Kaname; Itsuki Hamamoto; Yoshimi Tsuda; Xiaoyu Wen; Shuhei Taguwa; Kohji Moriishi; Osamu Takeuchi; Taro Kawai; Tatsuya Kanto; Norio Hayashi; Shizuo Akira; Yoshiharu Matsuura

  Journal of Virology, Sep. 2007, Peer-reviewed

  
• Alveolar Macrophages Are the Primary Interferon-α Producer in Pulmonary Infection with RNA Viruses

  Yutaro Kumagai; Osamu Takeuchi; Hiroki Kato; Himanshu Kumar; Kosuke Matsui; Eiichi Morii; Katsuyuki Aozasa; Taro Kawai; Shizuo Akira

  Immunity, 24 Aug. 2007, Peer-reviewed

  
• TLR4 signaling: Negative regulation by degradation

  Osamu Takeuchi; Shizuo Akira

  Blood, 01 Aug. 2007, Peer-reviewed

  
• A spatially and temporally restricted mouse model of soft tissue sarcoma

  David G. Kirsch; Daniela M. Dinulescu; John B. Miller; Jan Grimm; Philip M. Santiago; Nathan P. Young; G. Petur Nielsen; Bradley J. Quade; Christopher J. Chaber; Christian P. Schultz; Osamu Takeuchi; Roderick T. Bronson; Denise Crowley; Stanley J. Korsmeyer; Sam S. Yoon; Francis J. Hornicek; Ralph Weissleder; Tyler Jacks

  Nature Medicine, Aug. 2007, Peer-reviewed

  
• Pathogen recognition by innate immunity

  Osamu Takeuchi; Shizuo Akira

  Arerugī = [Allergy], Jun. 2007, Peer-reviewed

  
• Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

  Tatsukata Kawagoe; Shintaro Sato; Andreas Jung; Masahiro Yamamoto; Kosuke Matsui; Hiroki Kato; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira

  Journal of Experimental Medicine, May 2007, Peer-reviewed

  
• TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

  Michaela U. Gack; Young C. Shin; Chul Hyun Joo; Tomohiko Urano; Chengyu Liang; Lijun Sun; Osamu Takeuchi; Shizuo Akira; Zhijian Chen; Satoshi Inoue; Jae U. Jung

  Nature, Apr. 2007, Peer-reviewed

  
• Signaling pathways activated by microorganisms

  Osamu Takeuchi; Shizuo Akira

  Current Opinion in Cell Biology, Apr. 2007, Peer-reviewed

  
• The Biology of Toll-Like Receptors in Mice

  Osamu Takeuchi; Shizuo Akira

  The Mouse in Biomedical Research, 2007, Peer-reviewed

  
• Pathological role of Toll-like receptor signaling in cerebral malaria

  Cevayir Coban; Satoshi Uematsu; Nobuko Arisue; Shintaro Sato; Masahiro Yamamoto; Taro Kawai; Osamu Takeuchi; Hajime Hisaeda; Toshihiro Horii; Shizuo Akira

  International Immunology, Jan. 2007, Peer-reviewed

  
• Cutting edge: Pivotal function of Ubc13 in thymocyte TCR signaling

  Masahiro Yamamoto; Shintaro Sato; Tatsuya Saitoh; Hiroaki Sakurai; Satoshi Uematsu; Taro Kawai; Ken J. Ishii; Osamu Takeuchi; Shizuo Akira

  Journal of Immunology, 01 Dec. 2006, Peer-reviewed

  
• VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-κB inhibition

  Rabindra N. Bhattacharjee; Kwon Sam Park; Yutaro Kumagai; Kazuhisa Okada; Masahiro Yamamoto; Satoshi Uematsu; Kosuke Matsui; Himanshu Kumar; Taro Kawai; Tetsuya Iida; Takeshi Honda; Osamu Takeuchi; Shizuo Akira

  Journal of Biological Chemistry, 01 Dec. 2006, Peer-reviewed

  
• Cutting edge: Role of TANK-binding kinase 1 and inducible I kappa B kinase in IFN responses against viruses in innate inunune cells

  Kosuke Matsui; Yutaro Kumagai; Hiroki Kato; Shintaro Sato; Tatsukata Kawagoe; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira

  JOURNAL OF IMMUNOLOGY, Nov. 2006, Peer-reviewed

  
• Cutting edge: Role of TANK-binding kinase 1 and inducible IκB kinase in IFN responses against viruses in innate immune cells

  Kosuke Matsui; Yutaro Kumagai; Hiroki Kato; Shintaro Sato; Tatsukata Kawagoe; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira

  Journal of Immunology, 01 Nov. 2006, Peer-reviewed

  
• TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

  Shintaro Sato; Hideki Sanjo; Tohru Tsujimura; Jun Ninomiya-Tsuji; Masahiro Yamamoto; Taro Kawai; Osamu Takeuchi; Shizuo Akira

  International Immunology, Oct. 2006, Peer-reviewed

  
• Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

  Masahiro Yamamoto; Toru Okamoto; Kiyoshi Takeda; Shintaro Sato; Hideki Sanjo; Satoshi Uematsu; Tatsuya Saitoh; Naoki Yamamoto; Hiroaki Sakurai; Ken J. Ishii; Shoji Yamaoka; Taro Kawai; Yoshiharu Matsuura; Osamu Takeuchi; Shizuo Akira

  Nature Immunology, Sep. 2006, Peer-reviewed

  
• Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c⁺ lamina propria cells

  Satoshi Uematsu; Myoung Ho Jang; Nicolas Chevrier; Zijin Guo; Yutaro Kumagai; Masahiro Yamamoto; Hiroki Kato; Nagako Sougawa; Hidenori Matsui; Hirotaka Kuwata; Hiroaki Hemmi; Cevayir Coban; Taro Kawai; Ken J. Ishii; Osamu Takeuchi; Masayuki Miyasaka; Kiyoshi Takeda; Shizuo Akira

  Nature Immunology, Aug. 2006, Peer-reviewed

  
• Essential role of IPS-1 in innate immune responses against RNA viruses

  Himanshu Kumar; Taro Kawai; Hiroki Kato; Shintaro Sato; Ken Takahashi; Cevayir Coban; Masahiro Yamamoto; Satoshi Uematsu; Ken J. Ishii; Osamu Takeuchi; Shizuo Akira

  Journal of Experimental Medicine, 10 Jul. 2006, Peer-reviewed

  
• Cell type specific involvement of RIG-I in antiviral responses

  Hiroki Kato; Osamu Takeuchi; Shizuo Akira

  Nippon rinsho. Japanese journal of clinical medicine, Jul. 2006, Peer-reviewed

  
• Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

  Hiroki Kato; Osamu Takeuchi; Shintaro Sato; Mitsutoshi Yoneyama; Masahiro Yamamoto; Kosuke Matsui; Satoshi Uematsu; Andreas Jung; Taro Kawai; Ken J. Ishii; Osamu Yamaguchi; Kinya Otsu; Tohru Tsujimura; Chang Sung Koh; Caetano Reis E Sousa; Yoshiharu Matsuura; Takashi Fujita; Shizuo Akira

  Nature, 04 May 2006, Peer-reviewed

  
• Erratum: A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA (Nature Immunology (2005) vol. 7 (40-48))

  Ken J. Ishii; Cevayir Coban; Hiroki Kato; Ken Takahashi; Yuichi Torii; Fumihiko Takeshita; Holger Ludwig; Gerd Sutter; Koichi Suzuki; Hiroaki Hemmi; Shintaro Sato; Masahiro Yamamoto; Satoshi Uematsu; Taro Kawai; Osamu Takeuchi; Shizuo Akira

  Nature Immunology, Apr. 2006, Peer-reviewed

  
• Differential inductions of TNF-α and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides

  Nicolas Lapaque; Osamu Takeuchi; Fernando Corrales; Shizuo Akira; Ignacio Moriyon; Jonathan C. Howard; Jean Pierre Gorvel

  Cellular Microbiology, Mar. 2006, Peer-reviewed

  
• Pathogen recognition and innate immunity

  Shizuo Akira; Satoshi Uematsu; Osamu Takeuchi

  Cell, 24 Feb. 2006, Peer-reviewed

  
• A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA

  Ken J. Ishii; Cevayir Coban; Hiroki Kato; Ken Takahashi; Yuichi Torii; Fumihiko Takeshita; Holger Ludwig; Gerd Sutter; Koichi Suzuki; Hiroaki Hemmi; Shintaro Sato; Masahiro Yamamoto; Satoshi Uematsu; Taro Kawai; Osamu Takeuchi; Shizuo Akira

  Nature Immunology, Jan. 2006, Peer-reviewed

  
• Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest

  Rabindra N. Bhattacharjee; Kwon Sam Park; Satoshi Uematsu; Kazuhisa Okada; Katsuaki Hoshino; Kiyoshi Takeda; Osamu Takeuchi; Shizuo Akira; Tetsuya Iida; Takeshi Honda

  FEBS Letters, 05 Dec. 2005, Peer-reviewed

  
• Viral recognition and type I interferon production by Toll-like receptor and an RNA helicase, RIG-I

  H. Kato; T. Kawai; S. Uematsu; O. Takeuchi; S. Akira

  International Congress Series, Nov. 2005, Peer-reviewed

  
• Essential function for the kinase TAK1 in innate and adaptive immune responses

  Shintaro Sato; Hideki Sanjo; Kiyoshi Takeda; Jun Ninomiya-Tsuji; Masahiro Yamamoto; Taro Kawai; Kunihiro Matsumoto; Osamu Takeuchi; Shizuo Akira

  Nature Immunology, Nov. 2005, Peer-reviewed

  
• IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

  Taro Kawai; Ken Takahashi; Shintaro Sato; Cevayir Coban; Himanshu Kumar; Hiroki Kato; Ken J. Ishii; Osamu Takeuchi; Shizuo Akira

  Nature Immunology, Oct. 2005, Peer-reviewed

  
• Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus

  Rabindra N. Bhattacharjee; Kwon Sam Park; Kazuhisa Okada; Yutaro Kumagai; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira; Tetsuya Iida; Takeshi Honda

  Biochemical and Biophysical Research Communications, 23 Sep. 2005, Peer-reviewed

  
• Involvement of Toll-like receptor 2 in experimental invasive pulmonary Aspergillosis

  Viviane Balloy; Mustapha Si-Tahar; Osamu Takeuchi; Bruno Philippe; Marie Anne Nahori; Myriam Tanguy; Michel Huerre; Shizuo Akira; Jean Paul Latgé; Michel Chignard

  Infection and Immunity, Sep. 2005, Peer-reviewed

  
• Involvement of the virulence gene products of Yersinia enterocolitica in the immune response of infected mice

  O Takeuchi; T Suzuki; Kawamura, I; N Kobayashi; A Takizawa-Hashimoto; M Mitsuyama

  FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, Aug. 2005, Peer-reviewed

  
• Cell type-specific involvement of RIG-I in antiviral response

  Hiroki Kato; Shintaro Sato; Mitsutoshi Yoneyama; Masahiro Yamamoto; Satoshi Uematsu; Kosuke Matsui; Tohru Tsujimura; Kiyoshi Takeda; Takashi Fujita; Osamu Takeuchi; Shizuo Akira

  Immunity, Jul. 2005, Peer-reviewed

  
• Role of lipoteichoic acid in the phagocyte response to group B Streptococcus

  Philipp Henneke; Siegfried Morath; Satoshi Uematsu; Stefan Weichert; Markus Pfitzenmaier; Osamu Takeuchi; Andrea Müller; Claire Poyart; Shizuo Akira; Reinhard Berner; Giuseppe Teti; Armin Geyer; Thomas Hartung; Patrick Trieu-Cuot; Dennis L. Kasper; Douglas T. Golenbock

  Journal of Immunology, 15 May 2005, Peer-reviewed

  
• Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

  Satoshi Uematsu; Shintaro Sato; Masahiro Yamamoto; Tomonori Hirotani; Hiroki Kato; Fumihiko Takeshita; Michiyuki Matsuda; Cevayir Coban; Ken J. Ishii; Taro Kawai; Osamu Takeuchi; Shizuo Akira

  Journal of Experimental Medicine, 21 Mar. 2005, Peer-reviewed

  
• Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

  Tomonori Hirotani; Masahiro Yamamoto; Yutaro Kumagai; Satoshi Uematsu; Ichiro Kawase; Osamu Takeuchi; Shizuo Akira

  Biochemical and Biophysical Research Communications, 11 Mar. 2005, Peer-reviewed

  
• Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

  Cevayir Coban; Ken J. Ishii; Taro Kawai; Hiroaki Hemmi; Shintaro Sato; Satoshi Uematsu; Masahiro Yamamoto; Osamu Takeuchi; Sawako Itagaki; Nirbhay Kumar; Toshihiro Horii; Shizuo Akira

  Journal of Experimental Medicine, 03 Jan. 2005, Peer-reviewed

  
• Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart

  Pascal Knuefermann; Yasushi Sakata; J. Scott Baker; Chien Hua Huang; Kenichi Sekiguchi; Hordur S. Hardarson; Osamu Takeuchi; Shizuo Akira; Jesus G. Vallejo

  Circulation, 14 Dec. 2004, Peer-reviewed

  
• Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

  Taro Kawai; Shintaro Sato; Ken J. Ishii; Cevayir Coban; Hiroaki Hemmi; Masahiro Yamamoto; Kenta Terai; Michiyuki Matsuda; Jun Ichiro Inoue; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira

  Nature Immunology, Oct. 2004, Peer-reviewed

  
• Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis

  T Shimizu; H Niizeki; O Takeuchi; Y Yamasaki; N Inamoto; Y Kusunoki; K Kobayashi; R Abe; H Shimizu; T Nishikawa; K Hashiguchi; J Nishihira

  MEDIATORS OF INFLAMMATION, Aug. 2004, Peer-reviewed

  
• Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

  Masahiro Yamamoto; Soh Yamazaki; Satoshi Uematsu; Shintaro Sato; Hiroaki Hemmmi; Katsuaki Hoshino; Tsuneyasu Kaisho; Hirotaka Kuwata; Osamu Takeuchi; Koichiro Takeshige; Tatsuya Saitoh; Shoji Yamaoka; Naoki Yamamoto; Shunsuke Yamamoto; Tatsushi Muta; Kiyoshi Takeda; Shizuo Akira

  Nature, 08 Jul. 2004, Peer-reviewed

  
• The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

  Hiroaki Hemmi; Osamu Takeuchi; Shintaro Sato; Masahiro Yamamoto; Tsuneyasu Kaisho; Hideki Sanjo; Taro Kawai; Katsuaki Hoshino; Kiyoshi Takeda; Shizuo Akira

  Journal of Experimental Medicine, 21 Jun. 2004, Peer-reviewed

  
• Toll-like receptor 4 mediates the antitumor host response induced by a 55-Kilodalton protein isolated from Aeginetia indica L., a parasitic plant

  Masato Okamoto; Oh E. Go; Tetsuya Oshikawa; Sachiko Furuichi; Tomoyuki Tano; Sharif U. Ahmed; Sachiko Akashi; Kensuke Miyake; Osamu Takeuchi; Shizuo Akira; Kunisuke Himeno; Mitsunobu Sato; Shinya Ohkubo

  Clinical and Diagnostic Laboratory Immunology, May 2004, Peer-reviewed

  
• Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 4

  Amélie Honstettre; Eric Ghigo; Alix Moynault; Christian Capo; Rudolf Toman; Shizuo Akira; Osamu Takeuchi; Hubert Lepidi; Didier Raoult; Jean Louis Mege

  Journal of Immunology, 15 Mar. 2004, Peer-reviewed

  
• Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense

  Sylvia Knapp; Catharina W. Wieland; Cornelis Van't Veer; Osamu Takeuchi; Shizuo Akira; Sandrine Florquin; Tom Van Der Poll

  Journal of Immunology, 01 Mar. 2004, Peer-reviewed

  
• Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages

  Akiko Shiratsuchi; Ikuko Watanabe; Osamu Takeuchi; Shizuo Akira; Yoshinobu Nakanishi

  Journal of Immunology, 15 Feb. 2004, Peer-reviewed

  
• Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium

  M. Salomé Gomes; Manuela Flórido; João V. Cordeiro; C. Miguel Teixeira; Osamu Takeuchi; Shizuo Akira; Rui Appelberg

  Immunology, Feb. 2004, Peer-reviewed

  
• Roles of Toll-like receptor in host defense and the mechanism of its signal transduction

  O. Takeuchi; S. Akira

  Nippon saikingaku zasshi. Japanese journal of bacteriology, 2004, Peer-reviewed

  
• Interferon response by Toll-like receptor signaling

  Osamu Takeuchi; Hiroaki Hemmi; Shizuo Akira

  Journal of Endotoxin Research, 2004, Peer-reviewed

  
• Toll-Like Receptor-2 Modulates Ventricular Remodeling after Myocardial Infarction

  Tetsuro Shishido; Naoki Nozaki; Seiji Yamaguchi; Yoko Shibata; Joji Nitobe; Takuya Miyamoto; Hiroki Takahashi; Takanori Arimoto; Kunihiko Maeda; Mitsunori Yamakawa; Osamu Takeuchi; Shizuo Akira; Yasuchika Takeishi; Isao Kubota

  Circulation, 09 Dec. 2003, Peer-reviewed

  
• Normal Development of the Gut-Associated Lymphoid Tissue Except Peyer's Patch in MyD88-Deficient Mice

  R. Iiyama; T. Kanai; K. Uraushihara; T. Ishikura; S. Makita; T. Totsuka; M. Yamazaki; T. Nakamura; T. Miyata; H. Yoshida; O. Takeuchi; K. Hoshino; K. Takeda; H. Ishikawa; S. Akirat; M. Watanabe

  Scandinavian Journal of Immunology, Dec. 2003, Peer-reviewed

  
• TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

  Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Satoshi Uematsu; Katsuaki Hoshino; Tsuneyasu Kaisho; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira

  Nature Immunology, Nov. 2003, Peer-reviewed

  
• TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection

  Hye Seong Mun; Fumie Aosai; Kazumi Norose; Mei Chen; Lian Xun Piao; Osamu Takeuchi; Shizuo Akira; Hiroshi Ishikura; Akihiko Yano

  International Immunology, 01 Sep. 2003, Peer-reviewed

  
• CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes

  Norihito Yazawa; Manabu Fujimoto; Shinichi Sato; Kensuke Miyake; Noriko Asano; Yoshinori Nagai; Osamu Takeuchi; Kiyoshi Takeda; Hitoshi Okochi; Shizuo Akira; Thomas F. Tedder; Kunihiko Tamaki

  Blood, 15 Aug. 2003, Peer-reviewed

  
• Simultaneous blocking of human toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan

  Junji Uehori; Misako Matsumoto; Shoutaro Tsuji; Takashi Akazawa; Osamu Takeuchi; Shizuo Akira; Tsutomu Kawata; Ichiro Azuma; Kumao Toyoshima; Tsukasa Seya

  Infection and Immunity, 01 Aug. 2003, Peer-reviewed

  
• Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

  Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Katsuaki Hoshino; Tsuneyasu Kaisho; Hideki Sanjo; Osamu Takeuchi; Masanaka Sugiyama; Masaru Okabe; Kiyoshi Takeda; Shizuo Akira

  Science, 01 Aug. 2003, Peer-reviewed

  
• Candida albicans phospholipomannan is sensed through toll-like receptors

  Thierry Jouault; Stella Ibata-Ombetta; Osamu Takeuchi; Pierre André Trinel; Paola Sacchetti; Philippe Lefebvre; Shizuo Akira; Daniel Poulain

  Journal of Infectious Diseases, 01 Jul. 2003, Peer-reviewed

  
• Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-kappa B activation

  K Takeshita; Y Suzuki; K Nishio; O Takeuchi; K Toda; H Kudo; N Miyao; M Ishii; N Sato; K Naoki; T Aoki; K Suzuki; R Hiraoka; K Yamaguchi

  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Jul. 2003, Peer-reviewed

  
• Involvement of Toll-like receptor 4 signaling in interferon-γ production and antitumor effect by streptococcal agent OK-432

  Masato Okamoto; Tetsuya Oshikawa; Tomuyuki Tano; Go Ohe; Sachiko Furuichi; Hidetomo Nishikawa; Sharif Uddin Ahmed; Sachiko Akashi; Kensuke Miyake; Osamu Takeuchi; Shizuo Akira; Yoichiro Moriya; Shuzo Marsubara; Yoshiki Ryoma; Motoo Saito; Mitsunobu Sato

  Journal of the National Cancer Institute, 19 Feb. 2003, Peer-reviewed

  
• Involvement of toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432

  M Okamoto; T Oshikawa; T Tano; G Ohe; S Furuichi; H Nishikawa; SU Ahmed; S Akashi; K Miyake; O Takeuchi; S Akira; Y Moriya; S Matsubara; Y Ryoma; M Saito; M Sato

  JOURNAL OF THE NATIONAL CANCER INSTITUTE, Feb. 2003, Peer-reviewed

  
• Mycobacterial infection in TLR2 and TLR6 knockout mice

  Isamu Sugawara; Hiroyuki Yamada; Chuanyou Li; Satoru Mizuno; Osamu Takeuchi; Shizuo Akira

  Microbiology and Immunology, 2003, Peer-reviewed

  
• Synergistic effects of lipopolysaccharide and interferon-γ in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, toll-like receptor 4, MD-2 and MyD88 expression

  Riyoko Tamai; Shunji Sugawara; Osamu Takeuchi; Shizuo Akira; Haruhiko Takada

  Journal of Endotoxin Research, 2003, Peer-reviewed

  
• Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling

  Masahiro Yamamoto; Shintaro Sato; Kiyotoshi Mori; Katsuaki Hoshino; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira

  Journal of Immunology, 15 Dec. 2002, Peer-reviewed

  
• Cutting edge: A novel toll/IL-1 receptor Domain containing adapter that preferentially activates the IFN-beta promoter in the toll-like receptor signaling

  M Yamamoto; S Sato; K Mori; K Hoshino; O Takeuchi; K Takeda; S Akira

  JOURNAL OF IMMUNOLOGY, Dec. 2002, Peer-reviewed

  
• Differential recognition of structural details of bacterial lipopeptides by toll-like receptors

  Michael Morr; Osamu Takeuchi; Shizuo Akira; Markus M. Simon; Peter F. Mühlradt

  European Journal of Immunology, 01 Dec. 2002, Peer-reviewed

  
• Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

  Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Hideki Sanjo; Satoshi Uematsu; Tsuneyasu Kaisho; Katsuaki Hoshino; Osamu Takeuchi; Masaya Kobayashi; Takashi Fujita; Kiyoshi Takeda; Shizuo Akira

  Nature, 21 Nov. 2002, Peer-reviewed

  
• SOCS-1 participates in negative regulation of LPS responses

  Reiko Nakagawa; Tetsuji Naka; Hiroko Tsutsui; Minoru Fujimoto; Akihiro Kimura; Tatsuo Abe; Ekihiro Seki; Shintaro Sato; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira; Koichi Yamanishi; Ichirou Kawase; Kenji Nakanishi; Tadamitsu Kishimoto

  Immunity, 01 Nov. 2002, Peer-reviewed

  
• Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88- dependent signaling pathway

  Tomohiko Ogawa; Yasuyuki Asai; Masahito Hashimoto; Osamu Takeuchi; Tomoko Kurita; Yasunobu Yoshikai; Kensuke Miyake; Shizuo Akira

  International Immunology, 01 Nov. 2002, Peer-reviewed

  
• Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways

  Philipp Henneke; Osamu Takeuchi; Richard Malley; Egil Lien; Robin R. Ingalls; Mason W. Freeman; Tanya Mayadas; Victor Nizet; Shizuo Akira; Dennis L. Kasper; Douglas T. Golenbock

  Journal of Immunology, 01 Oct. 2002, Peer-reviewed

  
• Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice

  Ekihiro Seki; Hiroko Tsutsui; Noriko M. Tsuji; Nobuki Hayashi; Keishi Adachi; Hiroki Nakano; Shizue Futatsugi-Yumikura; Osamu Takeuchi; Katsuaki Hoshino; Shizuo Akira; Jiro Fujimoto; Kenji Nakanishi

  Journal of Immunology, 01 Oct. 2002, Peer-reviewed

  
• Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen

  Fumie Aosai; Mei Chen; Hyun Kyu Kang; Hye Seong Mun; Kazumi Norose; Lian Xun Piao; Masashi Kobayashi; Osamu Takeuchi; Shizuo Akira; Akihiko Yano

  Cell Stress and Chaperones, Oct. 2002, Peer-reviewed

  
• Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice

  M. Chen; F. Aosai; K. Norose; H. S. Mun; O. Takeuchi; S. Akira; A. Yano

  Journal of Parasitology, Oct. 2002, Peer-reviewed

  
• Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation

  K Hoshino; T Kaisho; T Iwabe; O Takeuchi; S Akira

  INTERNATIONAL IMMUNOLOGY, Oct. 2002, Peer-reviewed

  
• Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice

  Hideyuki Shimizu; Tetsuya Matsuguchi; Yoshihide Fukuda; Isao Nakano; Tetsuo Hayakawa; Osamu Takeuchi; Shizuo Akira; Masayuki Umemura; Takashi Suda; Yasunobu Yoshikai

  Gastroenterology, Oct. 2002, Peer-reviewed

  
• Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1

  T Yamao; T Noguchi; O Takeuchi; U Nishiyama; H Morita; T Hagiwara; H Akahori; T Kato; K Inagaki; H Okazawa; Y Hayashi; T Matozaki; K Takeda; S Akira; M Kasuga

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2002, Peer-reviewed

  
• Differential involvement of IFN-β in toll-like receptor-stimulated dendritic cell activation

  Katsuaki Hoshino; Tsuneyasu Kaisho; Tomio Iwabe; Osamu Takeuchi; Shizuo Akira

  International Immunology, 01 Oct. 2002, Peer-reviewed

  
• Involvement of Toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers

  Trude H. Flo; Liv Ryan; Eicke Latz; Osamu Takeuchi; Brian G. Monks; Egil Lien; Oyvind Halaas; Shizuo Akira; Gudmund Skjåk-Bræk; Douglas T. Golenbock; Terje Espevik

  Journal of Biological Chemistry, 20 Sep. 2002, Peer-reviewed

  
• Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells

  Naotake Tsuboi; Yasunobu Yoshikai; Seiichi Matsuo; Takeshi Kikuchi; Ken Ichiro Iwami; Yoshiyuki Nagai; Osamu Takeuchi; Shizuo Akira; Tetsuya Matsuguchi

  Journal of Immunology, 15 Aug. 2002, Peer-reviewed

  
• Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses

  Jenny Kim; Maria Teresa Ochoa; Stephan R. Krutzik; Osamu Takeuchi; Satoshi Uematsu; Annaliza J. Legaspi; Hans D. Brightbill; Diana Holland; William J. Cunliffe; Shizuo Akira; Peter A. Sieling; Paul J. Godowski; Robert L. Modlin

  Journal of Immunology, 01 Aug. 2002, Peer-reviewed

  
• Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

  Osamu Takeuchi; Shintaro Sato; Takao Horiuchi; Katsuaki Hoshino; Kiyoshi Takeda; Zhongyun Dong; Robert L. Modlin; Shizuo Akira

  Journal of Immunology, 01 Jul. 2002, Peer-reviewed

  
• Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation

  T Kaisho; K Hoshino; T Iwabe; O Takeuchi; T Yasui; S Akira

  INTERNATIONAL IMMUNOLOGY, Jul. 2002, Peer-reviewed

  
• Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages

  PS Coelho; A Klein; A Talvani; SF Coutinho; O Takeuchi; S Akira; JS Silva; H Canizzaro; RT Gazzinelli; MM Teixeira

  JOURNAL OF LEUKOCYTE BIOLOGY, May 2002, Peer-reviewed

  
• Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from trypanosoma cruzi Trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-γ-primed-macrophages

  Patrícia S. Coelho; André Klein; André Talvani; Sibele F. Coutinho; Osamu Takeuchi; Shizuo Akira; João S. Silva; Hélia Canizzaro; Ricardo T. Gazzinelli; Mauro M. Teixeira

  Journal of Leukocyte Biology, 01 May 2002, Peer-reviewed

  
• Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression

  R Tamai; T Sakuta; K Matsushita; M Torii; O Takeuchi; S Akira; S Akashi; T Espevik; S Sugawara; H Takada

  INFECTION AND IMMUNITY, Mar. 2002, Peer-reviewed

  
• Inhibition of growth of human hepatoma cells by dual-function antisense IL-6 oligonucleotides.

  Kumagai N; Tsuchimoto K; Tsunematsu S; Toda K; Takeuchi O; Saito H; Morizane T; Tsuchiya M; Ishii H

  Hepatology research : the official journal of the Japan Society of Hepatology, Feb. 2002, Peer-reviewed

  
• Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells

  M Saitoh; K Taguchi; K Momose; K Suga; N Yamazaki; C Ono; T Suzuki; O Takeuchi; S Yasuda; K Miyata

  CANCER CHEMOTHERAPY AND PHARMACOLOGY, Feb. 2002, Peer-reviewed

  
• Recognition of lipopeptides by Toll-like receptors

  Kiyoshi Takeda; Osamu Takeuchi; Shizuo Akira

  Journal of Endotoxin Research, 2002, Peer-reviewed

  
• A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways

  Shintaro Sato; Osamu Takeuchi; Takashi Fujita; Hideyuki Tomizawa; Kiyoshi Takeda; Shizuo Akira

  International Immunology, 2002, Peer-reviewed

  
• Endotoxin can induce MyD88-deficient dendritic cells to support Th2 cell differentiation

  Tsuneyasu Kaisho; Katsuaki Hoshino; Tomio Iwabe; Osamu Takeuchi; Teruhito Yasui; Shizuo Akira

  International Immunology, 2002, Peer-reviewed

  
• Genetic approaches to the study of Toll-like receptor function

  Osamu Takeuchi; Shizuo Akira

  Microbes and Infection, 2002, Peer-reviewed

  
• Small-antiviral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

  Hiroaki Hemmi; Tsuneyasu Kaisho; Osamu Takeuchi; Shintaro Sato; Hideki Sanjo; Katsuaki Hoshino; Takao Horiuchi; Hideyuki Tomizawa; Kiyoshi Takeda; Shizuo Akira

  Nature Immunology, 2002, Peer-reviewed

  
• Functional analysis of Toxoplasma gondii-derived HSP70 functions as a B cell mitogen

  F Aosai; M Chen; HK Kang; HS Mun; LX Piao; K Norose; O Takeuchi; S Akira; A Yano

  PROCEEDINGS OF THE 10TH INTERNATIONAL CONGRESS OF PARASITOLOGY-ICOPA X: SYMPOSIA, WORKSHOPS AND CONTRIBUTED PAPERS, 2002, Peer-reviewed

  
• MyD88 as a bottle neck in Toll/IL-1 signaling

  Otaake Takeuchi; S. Akira

  Current Topics in Microbiology and Immunology, 2002, Peer-reviewed

  
• Human gingival CD14⁺ fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression

  Riyoko Tamai; Tetsuya Sakuta; Kenji Matsushita; Mitsuo Torii; Osamu Takeuchi; Shizuo Akira; Sachiko Akashi; Terje Espevik; Shunji Sugawara; Haruhiko Takada

  Infection and Immunity, 2002, Peer-reviewed

  
• Novel engagement of CD14 and multiple toll-like receptors by group B streptococci

  P. Henneke; O. Takeuchi; J. A. Van Strijp; H. K. Guttormsen; J. A. Smith; A. B. Schromm; T. A. Espevik; S. Akira; V. Nizet; D. L. Kasper; D. T. Golenbock

  Journal of Immunology, 15 Dec. 2001, Peer-reviewed

  
• Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism

  K. Adachi; H. Tsutsui; S. I. Kashiwamura; E. Seki; H. Nakano; O. Takeuchi; K. Takeda; K. Okumura; L. Van Kaer; H. Okamura; S. Akira; K. Nakanishi

  Journal of Immunology, 15 Nov. 2001, Peer-reviewed

  
• Lipopolysaccharide stimulates the MyaD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

  T. Kawai; O. Takeuchi; T. Fujita; J. I. Inoue; P. F. Mühlradt; S. Sato; K. Hoshino; S. Akira

  Journal of Immunology, 15 Nov. 2001, Peer-reviewed

  
• Erratum: Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions (The Journal of Immunology (2001) 166 (2610-2616))

  M. Nishiguchi; M. Matsumoto; T. Takao; M. Hoshino; Y. Shimonishi; S. Tsuji; N. A. Begum; O. Takeuchi; S. Akira; Y. Nishizawa; K. Toyoshima; T. Seya

  Journal of Immunology, 15 Sep. 2001, Peer-reviewed

  
• Activation of toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite

  M. A.S. Campos; I. C. Almeida; O. Takeuchi; S. Akira; E. P. Valente; D. O. Procópio; L. R. Travassos; J. A. Smith; D. T. Golenbock; R. T. Gazzinelli

  Journal of Immunology, 01 Jul. 2001, Peer-reviewed

  
• Endotoxin-induced maturation of MyD88-deficient dendritic cells

  T. Kaisho; O. Takeuchi; T. Kawai; K. Hoshino; S. Akira

  Journal of Immunology, 01 May 2001, Peer-reviewed

  
• Induction of direct antimicrobial activity through mammalian toll-like receptors

  S. Thoma-Uszynski; S. Stenger; O. Takeuchi; M. T. Ochoa; M. Engele; P. A. Sieling; P. F. Barnes; M. Röllinghoff; P. L. Bölcskei; M. Wagner; S. Akira; M. V. Norgard; J. T. Belisle; P. J. Godowski; B. R. Bloom; R. L. Modlin

  Science, 23 Feb. 2001, Peer-reviewed

  
• Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β

  E. Seki; H. Tsutsui; H. Nakano; N. M. Tsuji; K. Hoshino; O. Adachi; K. Adachi; S. Futatsugi; K. Kuida; O. Takeuchi; H. Okamura; J. Fujimoto; S. Akira; K. Nakanishi

  Journal of Immunology, 15 Feb. 2001, Peer-reviewed

  
• Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions

  M. Nishiguchi; M. Matsumoto; T. Takao; M. Hoshino; Y. Shimonishi; S. Tsuji; N. A. Begum; O. Takeuchi; S. Akira; K. Toyoshima; T. Seya

  Journal of Immunology, 15 Feb. 2001, Peer-reviewed

  
• Discrimination of bacterial lipoproteins by Toll-like recepttor 6

  Osamu Takeuchi; Taro Kawai; Peter F. Mühlradt; Michael Morr; Justin D. Radolf; Arturo Zychlinsky; Kiyoshi Takeda; Shizuo Akira

  International Immunology, 2001, Peer-reviewed

  
• Toll-like receptors; their physiological role and signal transduction system

  Osamu Takeuchi; Shizuo Akira

  International Immunopharmacology, 2001, Peer-reviewed

  
• Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture

  S. Yang; R. Tamai; S. Akashi; O. Takeuchi; S. Akira; S. Sugawara; H. Takada

  Infection and Immunity, 2001, Peer-reviewed

  
• Monocytic cell activation by nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2

  S. Sugawara; S. Yang; K. Iki; J. Hatakeyama; R. Tamai; O. Takeuchi; S. Akashi; T. Espevik; S. Akira; H. Takada

  Infection and Immunity, 2001, Peer-reviewed

  
• CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression

  PY Perera; TN Mayadas; O Takeuchi; S Akira; M Zaks-Zilberman; SM Goyert; SN Vogel

  JOURNAL OF IMMUNOLOGY, Jan. 2001, Peer-reviewed

  
• Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways

  S. Sato; F. Nomura; T. Kawai; O. Takeuchi; P. F. Muhlradt; K. Takeda; S. Akira

  Journal of Immunology, 15 Dec. 2000, Peer-reviewed

  
• A Toll-like receptor recognizes bacterial DNA

  Hiroaki Hemmi; Osamu Takeuchi; Taro Kawai; Tsuneyasu Kaisho; Shintaro Sato; Hideki Sanjo; Makoto Matsumoto; Katsuaki Hoshino; Hermann Wagner; Kiyoshi Takeda; Shizuo Akira

  Nature, 07 Dec. 2000, Peer-reviewed

  
• Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

  O. Takeuchi; K. Hoshino; S. Akira

  Journal of Immunology, 15 Nov. 2000, Peer-reviewed

  
• Erratum: Cutting Edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway (Journal of Immunology (2000) 164 (554-557))

  O. Takeuchi; A. Kaufmann; K. Grote; T. Kawai; K. Hoshino; M. Morr; P. F. Muhlradt; S. Akira

  Journal of Immunology, 15 Nov. 2000, Peer-reviewed

  
• Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6

  Hans Häcker; Ramunas M. Vabulas; Osamu Takeuchi; Katsuaki Hoshino; Shizuo Akira; Hermann Wagner

  Journal of Experimental Medicine, 21 Aug. 2000, Peer-reviewed

  
• Expression of toll-like receptor 2 on γδ T cells bearing invariant Vγ6/Vδ1 induced by Escherichia coli infection in mice

  Yasuji Mokuno; Tetsuya Matsuguchi; Manabu Takano; Hitoshi Nishimura; Junji Washizu; Tomohiko Ogawa; Osamu Takeuchi; Shizuo Akira; Yuji Nimura; Yasunobu Yoshikai

  Journal of Immunology, 15 Jul. 2000, Peer-reviewed

  
• Mouse proteasomal ATPases Psmc3 and Psmc4: Genomic organization and gene targeting

  Yoshimitsu Sakao; Taro Kawai; Osamu Takeuchi; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Kiyoshi Takeda; Shizuo Akira

  Genomics, 01 Jul. 2000, Peer-reviewed

  
• Cytokine-inducing macromolecular glycolipids from enterococcus hirae: Improved method for separation and analysis of its effects on cellular activation

  Masahito Hashimoto; Yoshimasa Imamura; Toshiyuki Morichika; Kazumi Arimoto; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira; Kazue Aoyama; Toshihide Tamura; Shozo Kotani; Yasuo Suda; Shoichi Kusumoto

  Biochemical and Biophysical Research Communications, 24 Jun. 2000, Peer-reviewed

  
• Cutting edge: Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

  Osamu Takeuchi; Andreas Kaufmann; Karsten Grote; Taro Kawai; Katsuaki Hoshino; Michael Morr; Peter F. Mühlradt; Shizuo Akira

  Journal of Immunology, 15 Jan. 2000, Peer-reviewed

  
• Maturation of human dendritic cells by cell wall skeleton of Mycobacterium boris bacillus Calmette-Guérin: Involvement of toll-like receptors

  Shoutaro Tsuji; Misako Matsumoto; Osamu Takeuchi; Shizuo Akira; Ichiro Azuma; Akira Hayashi; Kumao Toyoshima; Tsukasa Seya

  Infection and Immunity, 2000, Peer-reviewed

  
• Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

  Osamu Takeuchi; Kiyoshi Takeda; Katsuaki Hoshino; Osamu Adachi; Tomohiko Ogawa; Shizuo Akira

  International Immunology, 2000, Peer-reviewed

  
• Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

  Osamu Takeuchi; Katsuaki Hoshino; Taro Kawai; Hideki Sanjo; Haruhiko Takada; Tomohiko Ogawa; Kiyoshi Takeda; Shizuo Akira

  Immunity, Oct. 1999, Peer-reviewed

  
• Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product

  Katsuaki Hoshino; Osamu Takeuchi; Taro Kawai; Hideki Sanjo; Tomohiko Ogawa; Yoshifumi Takeda; Kiyoshi Takeda; Shizuo Akira

  Journal of Immunology, Apr. 1999, Peer-reviewed

  
• TLR6: A novel member of an expanding Toll-like receptor family

  O. Takeuchi; T. Kawai; H. Sanjo; N. G. Copeland; D. J. Gilbert; N. A. Jenkins; K. Takeda; S. Akira

  Gene, Apr. 1999, Peer-reviewed

  
• TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation.

  Atsuko Wakabayashi; Masanori Yoshinaga; Osamu Takeuchi

  Life science alliance, Feb. 2022, Peer-reviewed, Last author, Corresponding author

  Access this paper :

  
• Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin.

  Yuki Hikichi; Yasutaka Motomura; Osamu Takeuchi; Kazuyo Moro

  The Journal of experimental medicine, 06 Dec. 2021, Peer-reviewed

  
• IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay.

  Kotaro Akaki; Kosuke Ogata; Yuhei Yamauchi; Noriki Iwai; Ka Man Tse; Fabian Hia; Atsushi Mochizuki; Yasushi Ishihama; Takashi Mino; Osamu Takeuchi

  eLife, 12 Oct. 2021, Peer-reviewed, Last author, Corresponding author

  Access this paper :

  

Misc.

• Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability

  Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Akaki Kotaro; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Tomonori Hirano; Yasuhide Takeuchi; Hiroyuki Miyoshi; Yoshiharu Sakai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa

  CANCER RESEARCH, Aug. 2020

  
• 特発性肺線維症における2型自然リンパ球の意義に関する包括的検討

  中塚 賀也; 半田 知宏; 渡邉 創; 谷澤 公伸; 村瀬 裕子; 池上 直弥; 庭本 崇史; 中西 智子; 陳 和夫; 竹内 理; 平井 豊博

  日本呼吸器学会誌, Mar. 2019

  
• RNA分解酵素Regnase-1による鉄代謝制御機構

  竹内理; 吉永正憲

  日本鉄バイオサイエンス学会学術集会プログラム・抄録集, 2018

  
• Identification of a novel post-transcriptional regulator in erythroid differentiation

  吉永正憲; 竹内理

  日本分子生物学会年会プログラム・要旨集(Web), 2021

  
• 鉄代謝を制御する転写後調節機構の解明

  吉永正憲; 三野享史; BASSIK Michael C; 竹内理

  日本RNA学会年会要旨集, 2018

  
• Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

  吉永正憲; 三野享史; 竹内理

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

  吉永正憲; 三野享史; 竹内理

  日本生化学会大会(Web), 2017

  
• Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

  吉永正憲; 三野享史; 竹内理

  日本RNA学会年会要旨集, 2017

  
• 免疫学アトラス 自然免疫とToll-like receptor

  竹内 理; 審良 静男

  免疫, 2001

  
• Sequential control of toll-like receptor-dependent responses by IRAK1 and IRAK2

  河越 龍方; 竹内 理; 審良 静男

  Clinical immunology & allergology, Feb. 2009

  
• Generation and analysis of IKKα-deficient mice

  TAKEDA Kiyoshi; TAKEUCHI Osamu; KAWAI Taro; AKIRA Shizuo

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Cloning of a new member of Toll-like receptor family

  TAKEUCHI Osamu; SANJO Hideki; KAWAI Taro; TAKEDA Kiyoshi; AKIRA Shizuo

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Isolation of cDNAs and organization of genomic genes for mouse TBP1 and TBP7, and generation of mice lacking TBP1 and TBP7

  SAKAO Yoshimitsu; KAWAI Taro; TAKEUCHI Osamu; TAKEDA Kiyoshi; AKIRA Shizuo

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Toll-like receptorと粘膜免疫 (〔2001年10月〕第1土曜特集 粘膜免疫の分子機構とその破綻) -- (粘膜免疫と生体防御機構)

  竹内 理; 審良 静男

  医学のあゆみ, 06 Oct. 2001

  
• Special Review Toll-like receptorノックアウトマウス

  竹内 理; 審良 静男

  細胞工学, May 2000

  
• The JMJD-IRF4 axis regulates M2 macrophage polarization and host responses against helminth infection

  佐藤 荘; 竹内 理; 審良 静男

  医学のあゆみ, 25 Jun. 2011

  
• Jmjd3はIRF4を介してM2マクロファージの活性化,及び寄生虫感染に対する生体防御応答を制御している (特集 免疫学からみたアレルギー(2)アレルギー担当細胞と誘導・制御分子)

  佐藤 荘; 竹内 理; 審良 静男

  アレルギ-・免疫, Apr. 2011

  
• 寄生植物ナンバンギセル由来55kDa蛋白のToll-like receptor 4を介したシグナル伝達

  大江 剛; 岡本 正人; 押川 哲也; 古市 幸子; 西川 英知; 田野 智之; 竹内 理; 審良 静男; 赤司 祥子; 三宅 健介

  日本癌学会総会記事, Sep. 2001

  
• The molecular mechanism of M2 macrophage differentiation

  佐藤 荘; 竹内 理; 審良 静男

  臨床免疫・アレルギー科, Dec. 2011

  
• RNAウイルスに対する感染防御応答におけるZinc-finger antiviral proteinの役割

  齊藤達哉; 齊藤達哉; LEE Hanna; LEE Hanna; 児崎達哉; 児崎達哉; 三澤拓馬; 三澤拓馬; 高濱充寛; 高濱充寛; 佐藤荘; 佐藤荘; 竹内理; 斉藤愛記; 山岡昇司; 山本直樹; 松浦善治; 駒野淳; 審良静男; 審良静男

  日本分子生物学会年会プログラム・要旨集(Web), 2013

  
• 生理学・医学賞 免疫を抑制する分子"PD-1"とがん免疫療法 (2018年ノーベル賞を読み解く)

  吉永 正憲; 竹内 理

  化学 = Chemistry, Dec. 2018

  
• Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow

  Takuya Uehata; Daisuke Ori; Masaki Miyazaki; Hiroshi Kawamoto; Osamu Takeuchi

  日本免疫学会学術集会, Dec. 2018

  
• A型肝炎ウイルスIRES依存的翻訳は肝臓特異的因子により活性化される

  貞廣暁利; 深尾亜喜良; 小坂実央; 滝沢直己; 船上仁範; 竹内理; DUNCAN Kent E.; 藤原俊伸

  日本RNA学会年会要旨集, 2018

  
• +鎖型一体鎖RNAウイルスの組織特異的IRES依存的翻訳機構の解析

  貞廣暁利; 深尾亜喜良; 滝沢直己; 船上仁範; 竹内理; 藤原俊伸

  RNAフロンティアミーティング, 2018, 2018

  
• 新規RNA分解酵素によるHIV-1感染制御機構の解明

  山岨大智; 佐藤佳; 佐藤佳; 小柳義夫; 竹内理

  日本生体防御学会学術総会講演抄録集, 2018

  
• MALT1によるN4BP1の分解は潜伏感染HIV-1の再活性化を促進する

  山岨大智; 佐藤佳; 小柳義夫; 竹内理

  日本エイズ学会誌, 2018

  
• Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity

  Yoshinari Nakatsuka; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Toyohiro Hirai Hirai; Osamu Takeuchi

  CYTOKINE, Dec. 2017

  
• A型肝炎ウイルスの細胞種特異性を生み出す,IRES依存的翻訳制御機構の解析

  貞廣暁利; 小坂実央; 深尾亜喜良; 竹内理; 藤原俊伸

  日本生化学会大会(Web), 2017

  
• Poliovirusの組織特異的増殖を生み出すIRES依存的翻訳機構の解明

  貞廣暁利; 深尾亜喜良; 竹内理; 藤原俊伸

  日本生化学会大会(Web), 2017

  
• ポリオウイルスの細胞種特異的なIRES依存的翻訳の解析

  貞廣暁利; 足達俊吾; 深尾亜喜良; 船上仁範; 夏目徹; 竹内理; 藤原俊伸

  日本分子生物学会年会プログラム・要旨集(Web), 2016

  
• Arl5BによるMDA5依存的な抗ウイルス自然免疫応答の抑制機構の解明

  鍛代悠一; 織大祐; 末吉拓也; 川崎拓実; 竹内理; 松田正; 審良静男; 河合太郎

  日本薬学会年会要旨集(CD-ROM), 2016

  
• ポリオウイルスの細胞種特異的なIRES依存的翻訳の解析

  貞廣暁利; 深尾亜喜良; 滝沢直己; 竹内理; 藤原俊伸

  日本生化学会大会(Web), 2015

  
• Regnase-1は翻訳に依存して炎症関連mRNAを分解する

  三野享史; 深尾亜喜良; 藤原俊伸; 竹内理

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo

  Kazuya Masuda; Barry Ripley; Riko Nishimura; Takashi Mino; Osamu Takeuchi; Go Shioi; Hiroshi Kiyonari; Tadamitsu Kishimoto

  CYTOKINE, Sep. 2013

  
• Regulation of 4-1BBL-mediated inflammation at the late phase of TLR response

  Young Kang; Jianhui Ma; Eun-Jin Shim; Jiawei Lu; So-Young Eun; Mick Croft; Peter Tobias; Osamu Takeuchi; Shizuo Akira; Jiahuai Han; Michael Karin

  JOURNAL OF IMMUNOLOGY, May 2013

  
• B lineage-specific deletion of Bim leads to lymphoproliferative and autoimmune disease

  Jacqueline Wright; Emily Clark; Osamu Takeuchi; Sandra Zinkel; Anne Satterthwaite; Wasif Khan

  JOURNAL OF IMMUNOLOGY, May 2012

  
• Posttranscriptional control of inflammation.

  Takeuchi O

  (Session organizer), 炎症の分子生物学, 第35回日本分子生物学会年会, No. 4S8I, 福岡12 月11-14 日,2012., 2012, Peer-reviewed

  
• O. Recognition of viral infection by innate immunity.

  Takeuchi O

  Signle Topic Conference “Hepatitis C: Best Practice Based on Science", Tokyo, November 21-22, 2012 ・, 2012, Peer-reviewed

  
• 生体の巧妙な炎症制御システムを探る

  竹内 理

  第52 回生命科学夏の学校, 愛知,8 月25日,2012., 2012, Peer-reviewed

  
• 自然免疫による炎症調節の分子機構

  竹内 理

  2012 年度京都大学ウイルス研究所学術講 演会, 京都,7 月26 日,2012, 2012, Peer-reviewed

  
• RNA分解酵素Regnase-1 による自然免疫制御

  竹内 理

  日本生化学会大会, 福岡,12月16日2012, 2012, Peer-reviewed

  
• 自然免疫における炎症の転写後調節メカニズム

  竹内 理

  第9 回ウイルス学キャンプin 湯河原、7月、2012, 2012, Peer-reviewed

  
• Functional characterization of protein domains common to animal viruses and mouse

  Akira R. Kinjo; Yutaro Kumagai; Huy Dinh; Osamu Takeuchi; Daron M. Standley

  10th Int. Conference on Bioinformatics - 1st ISCB Asia Joint Conference 2011, InCoB 2011/ISCB-Asia 2011: Computational Biology - Proceedings from Asia Pacific Bioinformatics Network (APBioNet), 2011, Peer-reviewed

  
• Regulation of immune responses by mRNA stability control

  TAKEUCHI Osamu

  生化學, 25 Dec. 2010

  
• OP-047-1 Poly I: C-induced anti-tumor effect of NK cells in CD8α^+dendritic cells via the IPS-1 and TRIF-dependent pathways(免疫-3,一般口演,第110回日本外科学会定期学術集会)

  三宅 亨; 加藤 博己; 竹内 理; 審良 静男; 谷 徹

  日本外科学会雑誌, 05 Mar. 2010

  
• IPS-1とTRIF-経路によるCD8α+樹状細胞におけるNK細胞のPoly I:C誘発性抗腫瘍効果(Poly I: C-induced anti-tumor effect of NK cells in CD8α+dendritic cells via the IPS-1 and TRIF-dependent pathways)

  三宅 亨; 加藤 博己; 竹内 理; 審良 静男; 谷 徹

  日本外科学会雑誌, Mar. 2010

  
• 自然免疫と自己免疫疾患

  松下 一史; 竹内 理; 審良 静男

  炎症と免疫, Dec. 2009

  
• 自然免疫における遺伝子発現制御 新規リボヌクレアーゼによる炎症応答の調節

  竹内 理; 松下 一史; 審良 静男

  蛋白質・核酸・酵素, Nov. 2009

  
• Tank is a negative regulator of TLR signaling and critical for preventing autoimmune nephritis

  Osamu Takeuchi; Tatsukata Kawagoe; Shizuo Akira

  CYTOKINE, Oct. 2009

  
• タンパク質分解を介した新たな生理機能 オートファジー関連分子Atg16L1はエンドトキシンによるインフラマソーム活性化を制御する(Atg16L1, an autophagy protein, controls endotoxin-induced inflammasome activation)

  齊藤 達哉; 藤田 尚信; 張 明浩; 植松 智; 梁 甫伎; 佐藤 荘; 大森 弘子; 野田 健司; 山本 直樹; 小松 雅明; 田中 啓二; 河合 太郎; 辻村 亨; 竹内 理; 吉森 保; 審良 静男

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008

  
• Tlr-7-dependent and Fc gamma R-independent production of type I interferon in experimental murine lupus

  Pui Y. Lee; Yutaro Kumagai; Yi Li; Jason Weinstein; Osamu Takeuchi; Dina Nacionales; Tole Barker; Taro Kawai; Minoru Satoh; Shizuo Akira; Westley Reeves

  ARTHRITIS AND RHEUMATISM, Sep. 2008

  
• S2-01 自然免疫によるRNAウイルス認識機構(シンポジウム2 和漢薬と生体防御,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)

  竹内 理; 審良 静男

  和漢医薬学雑誌, 20 Aug. 2007

  
• PATHOGEN RECOGNITION BY INNATE IMMUNITY

  Takeuchi Osamu; Akira Shizuo

  Japanese Journal of Allergology, 30 Jun. 2007

  
• DNAワクチン免疫原性誘導に必須な自然免疫認識シグナル経路

  石井健; 小山正平; 松井孝介; 植松智; 竹内理; 武下文彦; ジェバイ アチョバン; 審良静男

  日本ワクチン学会学術集会プログラム・抄録集, 2007

  
• 自然免疫--システム生物学的アプローチの果たしうる役割 (第1土曜特集 システム生物医学) -- (疾患のシステム生物医学)

  熊谷 雄太郎; 竹内 理; 審良 静男

  医学のあゆみ, 02 Dec. 2006

  
• Nucleic acid recognition pathways in innate immune cells. (Vol 6, pg 981, 2005)

  T Kawai; K Takahashi; S Sato; C Coban; H Kumar; H Kato; KJ Ishii; O Takeuchi; S Akira

  JOURNAL OF EXPERIMENTAL MEDICINE, Feb. 2006

  
• IRAK-1はTLR7とTLR9を解するIFN-α産生に必須の役割を果たす

  植松 智; 佐藤 慎太郎; 山本 雅裕; 加藤 博己; 石井 健; 河合 太郎; 竹内 理; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2005

  
• マウスstrawberry notch homologue遺伝子の解析

  坂尾 宣充; 植松 智; 竹内 理; 安居 輝人; 竹田 潔; 改正 恒康; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2005

  
• 2本鎖RNAにより活性化されるTLR3依存性,非依存性経路の機能的相違

  改正 恒康; 邊見 弘明; 山本 雅裕; 竹内 理; 星野 克明; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• Toll様受容体を介したI型IFN産生誘導のメカニズム

  河合 太郎; 佐藤 慎太郎; 石井 健; Coban Cevayir; 辺見 弘明; 山本 雅裕; 植松 智; 竹内 理; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• Plasmacytoid DCにおけるToll-like receptor 9によるtype Iインターフェロンの誘導機構

  植松 智; 佐藤 慎太郎; 山本 雅裕; 加藤 博己; 石井 健; 河合 太郎; 竹内 理; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• RIG-I欠損マウスの作成および解析

  加藤 博己; 佐藤 慎太郎; 山本 雅裕; 松井 孝介; 植松 智; 竹田 潔; 竹内 理; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• Roles of Toll-like receptor in host defense and the mechanism of its signal transduction

  Osamu Takeuchi; Shizuo Akira

  Nippon saikingaku zasshi. Japanese journal of bacteriology, Nov. 2004, Peer-reviewed

  
• Toll-like 2 Modulates Ventricular Remodeling After Myocardial Infarction

  宍戸 哲郎; 野崎 直樹; 二藤部 丈司; 宮本 卓也; 高橋 大; 有本 貴範; 竹石 恭知; 久保田 功; 山口 清司; 竹内 理; 審良 静男

  Circulation journal : official journal of the Japanese Circulation Society, 20 Oct. 2003

  
• TLR4刺激MyD88欠損樹状細胞のTh2細胞分化支持能の解析

  改正 恒康; 星野 克明; 竹内 理; 岩部 富夫; 審良 静男

  日本免疫学会総会・学術集会記録, Oct. 2002

  
• 各種DNAによる細胞活性化におけるTLR9の役割の検討

  邊見 弘明; 改正 恒康; 竹内 理; 星野 克明; 竹田 潔; 審良 静男

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• マウス樹状細胞におけるToll-like receptorを介した遺伝子発現機構の解析

  星野 克明; 岩部 富夫; 竹内 理; 改正 恒康; 審良 静男

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• LPS刺激MyD88欠損樹状細胞はTH2細胞分化支持能を有する

  改正 恒康; 星野 克明; 竹内 理; 岩部 富夫; 竹田 潔; 審良 静男

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• 自然免疫系活性化によるListeria monocytogenesの排除機構

  石 亦宏; 筒井 ひろ子; 辻 典子; 中埜 広樹; 安達 圭志; 竹内 理; 星野 克明; 審良 静男; 岡村 春樹; 藤元 治朗

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• Induction of proinflammatory mediators in the adult heart during Staphylococcus aureus sepsis: Role of Toll-like receptor 2 (TLR2)

  JG Vallejo; P Knuefermann; O Takeuchi; S Akira; N Sivasubramanian; DL Mann

  CLINICAL INFECTIOUS DISEASES, Oct. 2001

  
• Role of Toll-like receptor 2 (TLR2) in the induction of proinflammatory mediators in the adult heart during Staphylococcus aureus sepsis

  P Knuefermann; N Nozaki; S Nemoto; N Sivasubramanian; O Takeuchi; S Akira; DL Mann; JG Vallejo

  CIRCULATION, Oct. 2001

  
• Mycoplasma fermentans lipoprotein M161Ag-Induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions (vol 166, pg 2610, 2001)

  M Nishiguchi; M Matsumoto; T Takao; M Hoshino; Y Shimonishi; S Tsuji; NA Begum; O Takeuchi; S Akira; Y Nishizawa; K Toyoshima; T Seya

  JOURNAL OF IMMUNOLOGY, Sep. 2001

  
• OK-432由来複合糖質のToll-like receptor 4を介した抗腫瘍免疫増強効果

  岡本 正人; 大江 剛; 押川 哲也; 古市 幸子; 西川 英知; 田野 智之; シャリフ・ウディン・アーメッド; 竹内 理; 審良 静男; 赤司 祥子

  日本癌学会総会記事, Sep. 2001

  
• Toll-like receptor 2 signaling is important for Fas ligand on NKT cells, may contribute to liver injury induced by Salmonella infection.

  H Shimizu; Y Fukuda; Nakano, I; Y Katano; K Nagano; S Yokozaki; M Takeuchi; T Hayakawa; O Takeuchi; S Akira; T Matsuguchi; Y Yoshikai

  GASTROENTEROLOGY, Apr. 2001

  
• A Toll-like receptor recognizes bacterial DNA (vol 408, pg 740, 2000)

  H Hemmi; O Takeuchi; T Kawai; T Kaisho; S Sato; H Sanjo; M Matsumoto; K Hoshino; H Wagner; K Takeda; S Akira

  NATURE, Feb. 2001

  
• バクテリア由来非メチル化DNAによる免疫応答に必須なToll-like receptorの同定

  邊見 弘明; 竹内 理; 河合 太郎; 改正 恒康; 佐藤 慎太郎; 山条 秀樹; 星野 克明; 竹田 潔; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• MyD88欠損樹状細胞はエンドトキシン刺激により機能的に成熟する

  改正 恒康; 竹内 理; 河合 太郎; 星野 克明; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• MyD88を介さない新たなLPSシグナル伝達機構

  佐藤 慎太郎; 河合 太郎; 星野 克明; 竹内 理; 審良 静男

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• Interaction of CD14, CD11b/CD18, and TLR4 is required for full LPS- and Taxol-inducible gene expression

  PY Perera; TN Mayadas; O Takeuchi; S Akira; M Zaks-Zilberman; SM Goyert; SN Vogel

  JOURNAL OF LEUKOCYTE BIOLOGY, 2000

  
• MyD88は様々な細菌菌体成分に対する反応に必須である

  竹内 理; 星野 克明; 足達 治; 小川 知彦; 竹田 潔; 審良 静男

  日本免疫学会総会・学術集会記録, Oct. 1999

  
• TLR4(Toll like receptor 4)欠損マウスの作成と解析

  星野 克明; 竹内 理; 河合 太郎; 山条 秀樹; 小川 知彦; 竹田 潔; 審良 静男

  日本免疫学会総会・学術集会記録, Oct. 1999

  
• Limb and skin abnormalities in mice lacking IKKα

  Takeda K; Takeuchi O; Tsujimura T; Itami S; Adachi O; Kawai T; Sanjo H; Yoshikawa K; Terada N; Akira S

  Science, 1999

  
• 免疫細胞を制御するRNA結合タンパク質の機能解析

  植畑拓也; 山田信之輔; 織大祐; 今見考志; 宮崎正輝; 石濱泰; 河本宏; 竹内理

  日本分子生物学会年会プログラム・要旨集(Web), 2019

  
• Translational Control by 3' UTR Binding Protein

  山下 暁朗; 竹内 理

  細胞工学, 2015

  
• 自然免疫と炎症制御の分子機構 (特集 最新の免疫学 : 自然免疫・獲得免疫)

  織 大祐; 竹内 理

  医薬ジャーナル, Feb. 2013

  

Presentations

• Antiviral innate immunity targeting RNA

  Osamu Takeuchi

  6th European Congress of Immunology, 01 Sep. 2021, Invited

  
• Post-transcriptional control of inflammation-induced immune cell differentiation

  Osamu Takeuchi

  第73回日本細胞生物学会大会, 29 Jun. 2021, Invited

  
• Post-transcriptional regulation of innate immunity by Regnase-1

  Osamu Takeuchi

  The 27th International Symposium on Molecular Cell Biology of Macrophages (MMCB2020), 15 Jun. 2021, Invited

  
• RNA分解による免疫応答の制御機構

  竹内理

  2020年度東京大学医科学研究所国際共同利用・共同研究拠点成果報告会, 10 Mar. 2021, Invited

  
• Regnase-1による免疫調節機構

  竹内理

  第7回免疫セミナー, 05 Feb. 2021, Invited

  
• Immune regulation by translation-dependent mRNA decay

  竹内理

  日本分子生物学会年会, 02 Dec. 2020

  
• Manipulation of Regnase-1 mRNA stability alleviates inflammatory responses in diseased models

  Tse, K.M; Cui, X; Uehata, T; Takeuchi, O

  日本分子生物学会年会, Invited

  
• RNA代謝による自然免疫応答の惹起と制御

  竹内理

  日本臨床免疫学会総会, 15 Oct. 2020, Invited

  
• Regulatory mechanisms of innate immune responses

  Osamu Takeuchi

  FIMSA Immunology course-2020, 08 Oct. 2020, Invited

  

Industrial Property Rights

• 特許7258362号, 特願2020-507894, INFLAMMATION-SUPPRESSING COMPOSITION

  Osamu Takeuchi

  
• 特願2022-088931, がんを処置するための組成物

  竹内理; 植畑拓也

  
• 特願2021-187370, 肺高血圧症の検査方法、肺動脈性肺高血圧症の病態モデル動物、及び肺高血圧症の予防又は治療薬

  竹内理; 夜久愛; 中岡良和

  
• 特許第5650780号, 特開2017-114898, 特願2017-033269, ワクチン組成物

  深坂 昌弘; 岡崎 有道; 浅利 大介; 堀 光彦; 審良 静男; 竹内 理

  
• 特開2012-019768, 特願2010-162295, Jmjd3遺伝子改変非ヒト哺乳動物、Jmjd3遺伝子改変骨髄キメラ非ヒト哺乳動物、及びその利用

  審良 静男; 竹内 理; 佐藤 荘

  
• 特許第4236692号, 特開2008-173129, 特願2008-038054, マイコプラズマ由来リポタンパク/リポペプチド不応答性モデル非ヒト動物

  審良 静男; 竹内 理

  
• 特許第4197580号, WO2000-041561, 特願2000-593182, 細菌菌体成分不応答性モデルマウス

  審良 静男; 竹内 理; 竹田 潔

  

Awards

• 19 Apr. 2023

  令和５年度 科学技術分野の文部科学大臣表彰 科学技術賞(研究部門)
• 03 Dec. 2008

  Japanese Society for Immunology, 日本免疫学会研究奨励賞
• 24 Feb. 2016

  JSPS, JSPS Prize
• 24 Feb. 2016

  Japan Academy, Japan Academy Medal

External funds: Kakenhi

• コドンに隠された暗号の解明：ヒトコドン最適化制御による治療戦略

  Grant-in-Aid for JSPS Fellows

  Basic Section 48040:Medical biochemistry-related

  Kyoto University

  竹内 理

  From 24 Apr. 2020, To 31 Mar. 2022, Project Closed

  コドンバイアス;mRNA安定性;ｍRNA分解

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20F20115/
• Analysis of immune regulatory mechanisms mediated by mRNA metabolism

  Grant-in-Aid for Scientific Research (S)

  Broad Section H

  Kyoto University

  Osamu Takeuchi

  From 11 Jun. 2018, To 31 Mar. 2023, Project Closed

  炎症性疾患;mRNA分解;核酸医薬;免疫細胞分化;mRNA修飾;自然免疫応答;mRNA制御;ｍRNA分解;免疫応答;サイトカイン;免疫制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H05278/
• Control of immune responses via spatiotemporal regulation of mRNA decay

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  竹内 理

  From 01 Apr. 2018, To 31 Mar. 2019, Discontinued

  免疫応答;mRNA分解;転写後制御;自然免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H04027/
• The pathogenic role of Arid5a in infection and autoimmunity.

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  Kazuya MASUDA

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  自己免疫疾患;T細胞過剰活性化;RNA安定性制御;RNA結合タンパク質;転写後調節;IL-6 mRNA;STAT分子;Th17細胞;Arid5a;Regnase-1;インフルエンザ;感染・炎症;サイトカインストーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860328/
• Analysis of the mechanisms of an RNase, Zc3h12a-mediated immune regulation.

  Grant-in-Aid for Young Scientists (A)

  Kyoto University;Osaka University

  Osamu TAKEUCHI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  炎症;サイトカイン;mRNA安定性;自然免疫;シグナル伝達;RNA安定性;IkBキナーゼ;Zc3h12a;ユビキチン化;プロテオソーム;Toll-like receptor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22689016/
• Comprehensive study of innate immunity

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  Osaka University

  Shizuo AKIRA

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  自然免疫;炎症性疾患;感染症;サイトカイン;インターフェロン;生活習慣病;炎症;マクロファージ;好中球;パターン認識受容体;シグナル伝達;蛋白質分解;遺伝子発現;Toll-like receptor;エピジェネティクス;H3K27メチル化;ユビキチン化;病原体センサー;オートファジー;自己免疫疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20002008/
• 自然免疫系によるウイルス特異的分子パターン認識機構の解析

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  竹内 理

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  インターフェロン;ヘリカーゼ;シグナル伝達;ウイルス;樹状細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17790320/
• 抗腫瘍T細胞応答を調節する転写後制御機構の解析

  Grant-in-Aid for JSPS Fellows

  Basic Section 49070:Immunology-related

  Kyoto University

  From 16 Nov. 2022, To 31 Mar. 2024, Granted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22F22412/
• mRNA結合タンパク質による免疫制御機構の解明

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  竹内 理

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  免疫応答;mRNA分解;サイトカイン;コドン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00402/
• 抗腫瘍T細胞応答を調節する転写後制御機構の解析

  Grant-in-Aid for JSPS Fellows

  Basic Section 49070:Immunology-related

  Kyoto University

  竹内 理

  From 08 Mar. 2023, To 31 Mar. 2024, Granted

  RNA分解酵素;細胞傷害性T細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KF0226/
• 抗腫瘍T細胞応答を調節する転写後制御機構の解析

  Grant-in-Aid for JSPS Fellows

  Basic Section 49070:Immunology-related

  Kyoto University

  竹内 理

  From 23 Apr. 2024, To 31 Mar. 2025, Declined

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24KF0042/

External funds: others

• 日独免疫ワークショップ (2021年度分)

  Japan Society for the Promotion of Science (JSPS), 二国間交流事業共同研究・セミナー

  From 01 Apr. 2021, To 31 Mar. 2022

  代表者
• 日本学術振興会 最先端研究開発支援プログラム

  From 2010, To 2013

  竹内　理
• 免疫ダイナミズムの統合的理解と免疫制御法の確立

  日本学術振興会・最先端・次世代研究開発支援プログラム(平成24年度研究費)

  From 2012, To 2012
• 自然免疫における転写後調節を介した慢性炎症抑制メカニズムの解析

  JST, CREST

  From 01 Oct. 2012, To 31 Mar. 2018

  竹内　理
• RNA結合蛋白質のヒト炎症性疾患への関連性解明とその制御法開発

  革新的先端研究開発支援事業

  From 01 Apr. 2019, To 31 Mar. 2021

  竹内　理

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Immunology, Allergy and Infection (Practice for Master Program)

  E039, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Immunology, Allergy and Infection (Practice)

  P006, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Biochemistry

  M027, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Immunology I

  8014, Fall, Faculty of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Biochemistry

  B002, Spring, Faculty of Medicine, 2.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Immunology, Allergy and Infection (Seminar)

  P005, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Immunology, Allergy and Infection (Seminar for Master Program)

  E038, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Biochemistry

  M027, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Immunology I

  8014, Fall, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Biochemistry

  B002, Spring, Faculty of Medicine, 2.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Biochemistry

  B002, Spring, Faculty of Medicine, 2.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Immunology I

  8014, Fall, Faculty of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Biochemistry

  M027, Spring, Graduate School of Medicine, 2
• From Apr. 2013, To Mar. 2014

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2013, To Mar. 2014

  The Front Line of Life Science Research II

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  The Front Line of Life Science Research II

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  The Front Line of Life Science Research II

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Advanced Course in Immunology and Human Disorders

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Frontier in Life Sciences

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Basic Introduction in Medical Science

  Spring, 医学研究科
• From Apr. 2016, To Mar. 2017

  Interdisciplinary Sciences

  Fall, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2017, To Mar. 2018

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Interdisciplinary Sciences

  Fall, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Immunology I

  Fall, 医学部（人間健康科学科）
• From Apr. 2018, To Mar. 2019

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2018, To Mar. 2019

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Immunology I

  Fall, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Biochemistry

  Spring, 医学研究科
• From Apr. 2021, To Mar. 2022

  Immunology I

  Fall, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Biochemistry

  Spring, 医学研究科

Participation in PhD Defense

• Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules

  KOMATSU SHODAI, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection

  YI RENXING, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Deep generative design of RNA family sequences

  SUMI SHUNSUKE, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Synthetic circular RNA switches and circuits that control protein expression in mammalian cells

  KAMEDA SHIGETOSHI, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFκΒ pathway inhibition

  ISHIMURA TAKUYA, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2024
• Positive and negative regulation of the Fcγ receptor-stimulatory activity of RNA-containing immune complexes by RNase

  NAITO RYOTA, Graduate School of Medicine, Chief Examiner

  23 Jan. 2024
• Evolutional transition of HBV genome during the persistent infection determined by single-molecule real-time sequencing

  ARASAWA SOICHI, Graduate School of Medicine, Sub-chief Examiner

  24 Jul. 2023
• Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction

  KONEGAWA YASUSHI, Graduate School of Medicine, Chief Examiner

  24 Jul. 2023
• Knee alignment correction by high tibial osteotomy reduces symptoms and synovial inflammation in knee osteoarthritis accompanied by macrophage phenotypic change from M1 to M2

  YOSHIDA SHIGEO, Graduate School of Medicine, Sub-chief Examiner

  24 Jul. 2023
• Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation

  SAKAMOTO YUSUKE, Graduate School of Medicine, Chief Examiner

  23 May 2023
• Neutrophil Extracellular Traps Promote Metastases of Colorectal Cancers through Activation of ERK Signaling by Releasing Neutrophil Elastase

  OKAMOTO MICHIO, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Fetal macrophages assist in the repair of ruptured amnion through the induction of epithelial-mesenchymal transition

  KAWAMURA YOSUKE, Graduate School of Medicine, Chief Examiner

  23 May 2023
• Conserved Double Translation Initiation Site for Δ160p53 Protein Hints at Isoform’s Key Role in Mammalian Physiology

  MARIA JOSE LOPEZ INIESTA, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2023
• RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia

  KUBOTA HIROHITO, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• A Novel CD135+ Subset of Mouse Monocytes with a Distinct Differentiation Pathway and Antigen-Presenting Properties

  KAMIO NAOKA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

  Muna Mohamed Ahmed Al-Habsi, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase

  IIBUSHI JUNPEI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• 3D epigenome dynamics in normal and stalled development

  HU BO, Graduate School of Medicine, Sub-chief Examiner

  26 Sep. 2022
• Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis

  KUNO SOTA, Graduate School of Medicine, Chief Examiner

  25 Jul. 2022
• Activation of the β-adrenergic receptor exacerbates lipopolysaccharide-induced wasting of skeletal muscle cells by increasing interleukin-6 production

  MATSUKAWA SHINO, Graduate School of Medicine, Chief Examiner

  24 Sep. 2021
• B7-H3 suppresses anti-tumor immunity via the CCL2-CCR2-M2 macrophage axis and contributes to ovarian cancer progression

  MIYAMOTO TAITO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan

  YAMADA AKIHIRO, Graduate School of Medicine, Sub-chief Examiner

  24 Jan. 2022
• The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy

  INOUE YUTAKA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Generation of macrophages with altered viral sensitivity from genome-edited rhesus macaque iPSCs to model human disease

  IWAMOTO YOSHIHIRO, Graduate School of Medicine, Chief Examiner

  26 Jul. 2021
• IL4Rα and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype

  SUNADOME HIRONOBU, Graduate School of Medicine, Sub-chief Examiner

  24 May 2021
• CCL2-CCR2 signaling in the skin drives surfactant-induced irritant contact dermatitis via IL-1β-mediated neutrophil accumulation

  SHIBUYA RINTARO, Graduate School of Medicine, Chief Examiner

  24 Nov. 2021

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  国際高等教育院 企画評価専門委員会 化学部会
• From 01 Oct. 2012, To 30 Sep. 2014

  動物実験委員会 委員
• From 01 Oct. 2016, To 30 Sep. 2018

  京都大学動物実験委員会 副委員長
• 医学図書館運営委員会　委員
• From 21 Dec. 2017, To 31 Mar. 2019

  国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員
• From 01 Apr. 2020, To 30 Sep. 2020

  組換えＤＮＡ実験安全委員会 委員

Faculty management (title, position)

• From 01 Jan. 2024, To 31 Dec. 2025

  京都大学医学部教育研究支援基金委員会_委員
• From 01 Oct. 2022, To 30 Sep. 2024

  京都大学医学研究科・医学部動物実験委員会
• From 01 Oct. 2022, To 30 Sep. 2024

  管理体制委員会委員
• From 01 Apr. 2013, To 31 Mar. 2014

  予算委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2015

  予算委員会　委員長
• From 01 Apr. 2013, To 31 Mar. 2014

  広報委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2015

  広報委員会　委員長
• From 01 Apr. 2014, To 31 Mar. 2015

  職員等配置検討委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2017

  兼業審査委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2018

  動物実験委員会　委員
• From 01 Apr. 2015, To 31 Mar. 2017

  霊長類委員会　委員
• From 01 Apr. 2015, To 31 Mar. 2017

  自己点検・評価委員会　委員
• From 01 Apr. 2016, To 31 Mar. 2018

  予算委員会
• From 01 Oct. 2016

  動物実験委員会　委員
• From 01 Oct. 2016

  ウイルス動物実験専門委員会　委員
• From 01 Oct. 2016

  霊長類動物実験専門委員会　委員
• From 01 Oct. 2016

  兼業・利益相反審査員会　委員
• From 01 Oct. 2016

  （旧ウイルス研）予算委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2021

  将来計画検討委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  医学図書館運営委員会 委員
• To 30 Sep. 2020

  医学研究科運営委員会 委員
• M.D.－Ph.D.コース運営委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  入学者選抜方法検討員　委員
• From 01 Apr. 2020, To 31 Mar. 2022

  動物実験施設管理委員会
• From 01 Jan. 2020, To 31 Dec. 2021

  教育研究支援基金委員会
• From 01 Oct. 2020, To 30 Sep. 2022

  動物実験委員会委員
• From 01 Apr. 2021, To 31 Mar. 2023

  入学者選抜方法検討委員会委員