Basic Information

Faculty

• Faculty of Medicine

Email Address

• Email Address

  matsui.shigeyuki.5ykyoto-u.ac.jp

Academic Degree

• 20 Mar. 1993

  東京理科大学修士（工学）
• 20 Mar. 1999

  東京理科大学博士（工学）

Academic Resume (Graduate Schools)

• 東京理科大学, 大学院工学研究科後期博士課程経営工学専攻, 修了
• 東京理科大学, 大学院工学研究科博士後期課程経営工学専攻, 研究指導認定退学
• 東京理科大学, 大学院工学研究科修士課程経営工学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 東京理科大学, 工学部第１部経営工学科, 卒業

ID,URL

• ORCID ID

  0000-0003-2983-1919

• J-Global ID

  200901090119171846

• Researcher number

  80305854

researchmap URL

• https://researchmap.jp/read0095894

Research

Research Areas

• Natural sciences, Applied mathematics and statistics

Papers

• Rhythm-specific association of epinephrine with outcomes in non-shockable cardiac arrest: a nationwide propensity-matched study.

  Ryo Emoto; Mitsuaki Nishikimi; Kazuya Kikutani; Junki Ishii; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime; Taku Iwami

  Resuscitation, 30 Apr. 2026

  Access this paper :

  
• Consciousness Disturbances Reported With Clindamycin Versus Cefazolin in Surgical Patients: A Global Pharmacovigilance Analysis Using VigiBase.

  Kazuki Nishida; Basile Chrétien; Hiroshi Morioka; Daigo Tamakoshi; Keita Hiraga; Tomoyuki Nakamura; Shigeyuki Matsui; Masahisa Katsuno; Yoshitaka Hara

  Clinical and translational science, Apr. 2026

  
• Impact of post-decannulation high fever on mortality in patients with severe ARDS treated with veno-venous ECMO: a multicenter retrospective study.

  Kenji Fujizuka; Mitsuaki Nishikimi; Kazuya Kikutani; Ryo Emoto; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime; Hiroyuki Suzuki

  Journal of intensive care, 11 Feb. 2026

  
• Positive ascites cytology in interval debulking surgery predicts poor outcomes of advanced epithelial ovarian cancer achieving complete tumor resection

  Marina Yoshikawa; Masato Yoshihara; Ryo Emoto; Shigeyuki Matsui; Hiroaki Kajiyama

  Scientific Reports, 10 Feb. 2026

  
• Subphenotype-Specific Risk of Intracranial Hemorrhage During Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome.

  Mitsuaki Nishikimi; Shinichiro Ohshimo; Wataru Fukumoto; Ryo Emoto; Kazuo Awai; Shigeyuki Matsui; Nobuaki Shime

  ASAIO journal (American Society for Artificial Internal Organs : 1992), 13 Jan. 2026

  
• Neurological outcomes with hypothermia versus normothermia in patients with moderate initial illness severity following resuscitation from out-of-hospital cardiac arrest: protocol for a multicentre randomised controlled trial (R-CAST OHCA).

  Hiromichi Naito; Mitsuaki Nishikimi; Yohei Okada; Hiroki Maeyama; Takeyuki Kiguchi; Takashi Yorifuji; Kazuki Nishida; Shigeyuki Matsui; Yasuhiro Kuroda; Kei Nishiyama; Taku Iwami; Atsunori Nakao

  BMJ open, 22 Aug. 2025

  
• Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer: a multicenter retrospective cohort study.

  Hiroki Fujimoto; Masato Yoshihara; Carmela Ricciardelli; Sho Tano; Shohei Iyoshi; Emiri Miyamoto; Kazumasa Mogi; Maia Hayashi; Sae Hayakawa; Satoshi Nomura; Kazuhisa Kitami; Kaname Uno; Nobuhisa Yoshikawa; Ryo Emoto; Shigeyuki Matsui; Hiroaki Kajiyama

  Scientific reports, 09 Oct. 2024

  
• Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery.

  Kazumasa Mogi; Masato Yoshihara; Ryo Emoto; Emiri Miyamoto; Hiroki Fujimoto; Kaname Uno; Sho Tano; Shohei Iyoshi; Kazuhisa Kitami; Nobuhisa Yoshikawa; Shigeyuki Matsui; Hiroaki Kajiyama

  PloS one, 2024

  
• Development and Validation of Predictive Risk Scores for Ovarian Clear Cell Carcinoma: A Penalized Regression Model.

  Shohei Iyoshi; Ryo Emoto; Nobuhisa Yoshikawa; Kosuke Yoshida; Masato Yoshihara; Satoshi Tamauchi; Akira Yokoi; Yusuke Shimizu; Yoshiki Ikeda; Kaoru Niimi; Michiyasu Kawai; Shigeyuki Matsui; Hiroaki Kajiyama

  Cancer medicine, Aug. 2025

  
• Detailed analysis of the histology-specific impact of ascites volume on the outcome of epithelial ovarian cancer: a multi-institutional retrospective cohort study.

  Shohei Iyoshi; Mariko Kimura; Masato Yoshihara; Atsushi Kunishima; Emiri Miyamoto; Hiroki Fujimoto; Kazuhisa Kitami; Kazumasa Mogi; Kaname Uno; Sho Tano; Nobuhisa Yoshikawa; Ryo Emoto; Shigeyuki Matsui; Hiroaki Kajiyama

  BMC cancer, 29 Nov. 2024

  
• Long-term prognostic significance of ascites cytology in ovarian cancer cases in which R0 resection was achieved in the initial surgery: a multi-institutional retrospective cohort study.

  Shohei Iyoshi; Mayuko Sunohara; Masato Yoshihara; Atsushi Kunishima; Emiri Miyamoto; Hiroki Fujimoto; Kazuhisa Kitami; Kazumasa Mogi; Kaname Uno; Kosuke Yoshida; Satoshi Tamauchi; Akira Yokoi; Kaoru Niimi; Nobuhisa Yoshikawa; Ryo Emoto; Shigeyuki Matsui; Hiroaki Kajiyama

  Japanese journal of clinical oncology, 20 Mar. 2025

  
• Evaluating treatment effect modifiers using data from randomized two-sequence, two-period crossover clinical trials: application to a diabetes study

  Ryo Emoto; Masataka Igeta; Kota Matsui; Kiyoaki Ishii; Toshinari Takamura; Shigeyuki Matsui

  Journal of the Royal Statistical Society Series C: Applied Statistics, 06 Feb. 2025

  
• Effect Size of Targeted Temperature Management in Pediatric Patients with Post-Cardiac Arrest Syndrome According to the Severity.

  Takeshi Namba; Mitsuaki Nishikimi; Ryo Emoto; Kazuya Kikutani; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime

  Life (Basel, Switzerland), 30 Dec. 2024

  
• Development of a machine learning-based risk model for postoperative complications of lung cancer surgery.

  Yuka Kadomatsu; Ryo Emoto; Yoko Kubo; Keita Nakanishi; Harushi Ueno; Taketo Kato; Shota Nakamura; Tetsuya Mizuno; Shigeyuki Matsui; Toyofumi Fengshi Chen-Yoshikawa

  Surgery today, Dec. 2024

  
• Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study.

  Kazuya Kikutani; Mitsuaki Nishikimi; Ryo Emoto; Shigeyuki Matsui; Hiroyuki Ohbe; Takayuki Ogura; Satoru Hashimoto; Shigeki Kushimoto; Shinhiro Takeda; Shinichiro Ohshimo; Nobuaki Shime

  Journal of intensive care, 05 Nov. 2024

  
• Identifying Subgroups with Differential Responses to Amiodarone among Cardiac Arrest Patients with a Shockable Rhythm at Hospital Arrival using the Machine Learning Approach.

  Ryo Emoto; Mitsuaki Nishikimi; Kazuya Kikutani; Junki Ishii; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime

  Reviews in cardiovascular medicine, Jul. 2024

  
• 完全腫瘍切除された上皮性卵巣がん患者での組織型毎の予後検討

  茂木 一将; 吉原 雅人; 江本 遼; 宮本 絵美里; 藤本 裕基; 宇野 枢; 伊吉 祥平; 玉内 学志; 清水 裕介; 横井 暁; 池田 芳樹; 芳川 修久; 新美 薫; 松井 茂之; 梶山 広明

  日本癌治療学会学術集会抄録集, Oct. 2023

  
• 完全腫瘍切除された上皮性卵巣がん患者での組織型毎の予後検討

  茂木 一将; 吉原 雅人; 江本 遼; 宮本 絵美里; 藤本 裕基; 宇野 枢; 伊吉 祥平; 玉内 学志; 清水 裕介; 横井 暁; 池田 芳樹; 芳川 修久; 新美 薫; 松井 茂之; 梶山 広明

  日本癌治療学会学術集会抄録集, Oct. 2023

  
• Prognostic impact of highly solid component in early-stage solid lung adenocarcinoma

  Taketo Kato; Shingo Iwano; Yuki Hanamatsu; Masato Nakaguro; Ryo Emoto; Shoji Okado; Keiyu Sato; Osamu Noritake; Keita Nakanishi; Yuka Kadomatsu; Harushi Ueno; Naoki Ozeki; Shota Nakamura; Koichi Fukumoto; Tamotsu Takeuchi; Kennosuke Karube; Shigeyuki Matsui; Toyofumi Fengshi Chen-Yoshikawa

  Quantitative Imaging in Medicine and Surgery, 01 Sep. 2023

  
• Factors associated with adverse drug reactions or death in very elderly hospitalized patients with pulmonary tuberculosis.

  Mitsuaki Yagi; Yuichiro Shindo; Yoshikazu Mutoh; Masahiro Sano; Toshihiro Sakakibara; Hironori Kobayashi; Akinobu Matsuura; Ryo Emoto; Shigeyuki Matsui; Taku Nakagawa; Kenji Ogawa

  Scientific reports, 26 Apr. 2023

  
• Efficacy of Endoscopic Ultrasound-guided Celiac Plexus Neurolysis for Abdominal Pain in Patients With Unresectable Pancreatic Cancer: Network Meta-analysis of Randomized Controlled Trials.

  Okita M; Otani K; Matsui S

  Journal of clinical gastroenterology, 11 Oct. 2022

  
• Who are the long-term survivors of recurrent ovarian carcinoma?: a retrospective analysis of a multicenter study.

  Masato Yoshihara; Kazumasa Mogi; Kazuhisa Kitami; Kaname Uno; Shohei Iyoshi; Sho Tano; Hiroki Fujimoto; Emiri Miyamoto; Nobuhisa Yoshikawa; Ryo Emoto; Shigeyuki Matsui; Hiroaki Kajiyama

  International journal of clinical oncology, Oct. 2022

  
• Blinded sample size re-estimation for comparing over-dispersed count data incorporating follow-up lengths

  Masataka Igeta; Shigeyuki Matsui

  STATISTICS IN MEDICINE, 23 Sep. 2022

  
• Extended-spectrum antibiotics for community-acquired pneumonia with a low risk for drug-resistant pathogens.

  Hironori Kobayashi; Yuichiro Shindo; Daisuke Kobayashi; Toshihiro Sakakibara; Yasushi Murakami; Mitsuaki Yagi; Akinobu Matsuura; Kenta Sato; Kota Matsui; Ryo Emoto; Tetsuya Yagi; Hideo Saka; Shigeyuki Matsui; Yoshinori Hasegawa

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 16 Sep. 2022

  
• Bias correction based on weighted likelihood for conditional estimation of subgroup effects in randomized clinical trials

  Toyoizumi Kiichiro; Matsui Shigeyuki

  STATISTICS IN MEDICINE, 02 Sep. 2022

  
• 糖尿病、肥満、がんとの関係を臨床・疫学・メカニズムから紐解く 卵巣癌腹膜播種の形成における肥満の影響と脱分化脂肪細胞の役割(Impact of obesity and the role of dedifferentiated adipocytes upon peritoneal metastasis of ovarian cancer)

  伊吉 祥平; 吉原 雅人; 中村 香江; 角 朝美; 杉山 麻衣; 小屋 美博; 宮本 絵美里; 藤本 裕基; 茂木 一将; 宇野 枢; 北見 和久; 江本 遼; 松井 茂之; 那波 明宏; 梶山 広明

  日本癌学会総会記事, Sep. 2022

  
• 院外心停止例での体温管理療法に関する無作為化比較試験

  内藤 宏道; 錦見 満暁; 岡田 遥平; 前山 博輝; 木口 雄之; 西田 一貴; 松井 茂之; 黒田 泰弘; 西山 慶; 石見 拓; 中尾 篤典

  日本脳低温療法・体温管理学会誌, Sep. 2022

  
• 院外心停止例での体温管理療法に関する無作為化比較試験

  内藤 宏道; 錦見 満暁; 岡田 遥平; 前山 博輝; 木口 雄之; 西田 一貴; 松井 茂之; 黒田 泰弘; 西山 慶; 石見 拓; 中尾 篤典

  日本脳低温療法・体温管理学会誌, Sep. 2022

  
• Systematic review and meta-analysis of celiac plexus neurolysis for abdominal pain associated with unresectable pancreatic cancer

  Okita Muneyori; Otani Kazuki; Gibo Noriaki; Matsui Shigeyuki

  PAIN PRACTICE, Sep. 2022

  
• Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia

  Yasushi Murakami; Yuichiro Shindo; Masahiro Sano; Junya Okumura; Hironori Kobayashi; Toshihiro Sakakibara; Mitsutaka Iguchi; Kunihiko Takahashi; Tetsuya Yagi; Shigeyuki Matsui; Yoshinori Hasegawa

  Scientific Reports, 26 Aug. 2022

  
• The finger-to-nose test improved diagnosis of cerebrovascular events in patients presenting with isolated dizziness in the emergency department.

  Kazuki Nishida; Takuya Usami; Nana Matsumoto; Mitsuaki Nishikimi; Kunihiko Takahashi; Shigeyuki Matsui

  Nagoya journal of medical science, Aug. 2022

  
• Obesity contributes to the stealth peritoneal dissemination of ovarian cancer: a multi-institutional retrospective cohort study

  Iyoshi Shohei; Sumi Asami; Yoshihara Masato; Kitami Kazuhisa; Mogi Kazumasa; Uno Kaname; Fujimoto Hiroki; Miyamoto Emiri; Tano Sho; Yoshikawa Nobuhisa; Emoto Ryo; Matsui Shigeyuki; Kajiyama Hiroaki

  OBESITY, Aug. 2022

  
• Effect of omega-3 fatty acids on cardiovascular events in high-risk patients with hypertriglyceridemia in Japan: a 3-year post-marketing surveillance study (OCEAN3 survey).

  Tamio Teramoto; Hisao Ogawa; Hirotsugu Ueshima; Yasushi Okada; Kazuo Haze; Shigeyuki Matsui; Keita Fujikawa; Takamasa Hashimoto; Sho Sakui; Kunihiko Nishimura; Mika Kajita; Atsushi Horimoto; Jovelle Fernandez

  Expert opinion on drug safety, 10 Jul. 2022

  
• Machine learning prediction models for postpartum depression: A multicenter study in Japan.

  Seiko Matsuo; Takafumi Ushida; Ryo Emoto; Yoshinori Moriyama; Yukako Iitani; Noriyuki Nakamura; Kenji Imai; Tomoko Nakano-Kobayashi; Shigeru Yoshida; Mamoru Yamashita; Shigeyuki Matsui; Hiroaki Kajiyama; Tomomi Kotani

  The journal of obstetrics and gynaecology research, Jul. 2022

  
• Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out-of-Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry.

  Ryo Emoto; Mitsuaki Nishikimi; Muhammad Shoaib; Kei Hayashida; Kazuki Nishida; Kazuya Kikutani; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime; Taku Iwami

  Journal of the American Heart Association, 21 Jun. 2022

  
• Epicardial adipose tissue volume is associated with abdominal aortic aneurysm expansion.

  Kawai Y; Banno H; Sato T; Ikeda S; Tsuruoka T; Sugimoto M; Niimi K; Kodama A; Matsui K; Matsui S; Komori K

  Journal of vascular surgery, 01 Jun. 2022

  
• Dynamic Risk Prediction via a Joint Frailty-Copula Model and IPD Meta-Analysis: Building Web Applications

  Emura Takeshi; Michimae Hirofumi; Matsui Shigeyuki

  ENTROPY, May 2022

  
• Broad-Spectrum Antibiotics and Mortality in Community-Acquired Pneumonia Patients with Low-Risk for Drug-Resistant Pathogens

  Kobayasi H; Shindo Y; Kobayashi D; Sakakibara T; Murakami Y; Yagi M; Matsuura A; Sato K; Goto Y; Matsui S; Yagi T; Saka H; Hasegawa Y

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 01 May 2022

  
• Risk factors for antibiotic resistance in hospital-acquired and ventilator-associated pneumonia

  Masahiro Sano; Yuichiro Shindo; Kunihiko Takahashi; Junya Okumura; Toshihiro Sakakibara; Yasushi Murakami; Mitsutaka Iguchi; Tetsuya Yagi; Shigeyuki Matsui; Yoshinori Hasegawa

  Journal of Infection and Chemotherapy, Feb. 2022, Peer-reviewed

  
• A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study

  Toshihiro Sakakibara; Yuichiro Shindo; Daisuke Kobayashi; Masahiro Sano; Junya Okumura; Yasushi Murakami; Kunihiko Takahashi; Shigeyuki Matsui; Tetsuya Yagi; Hideo Saka; Yoshinori Hasegawa

  BMC Pulmonary Medicine, Jan. 2022, Peer-reviewed

  
• 初期粘液性卵巣癌における系統的リンパ節郭清の意義 プロペンシティスコア解析

  茂木 一将; 吉原 雅人; 玉内 学志; 伊吉 祥平; 横井 暁; 河井 通泰; 長坂 徹郎; 高橋 邦彦; 松井 茂之; 梶山 広明

  日本癌治療学会学術集会抄録集, Oct. 2021

  
• Postoperative stroke and neurological outcomes in the early phase after revascularization surgeries for moyamoya disease: an age-stratified comparative analysis.

  Yoshio Araki; Kinya Yokoyama; Kenji Uda; Fumiaki Kanamori; Michihiro Kurimoto; Yoshiki Shiba; Takashi Mamiya; Masahiro Nishihori; Takashi Izumi; Masaki Sumitomo; Sho Okamoto; Kota Matsui; Ryo Emoto; Toshihiko Wakabayashi; Shigeyuki Matsui; Atsushi Natsume

  Neurosurgical review, Oct. 2021

  
• Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery.

  Toshihiko Nishi; Masato Mutsuga; Toshiaki Akita; Yuji Narita; Kazuro Fujimoto; Yoshiyuki Tokuda; Kazuki Nishida; Shigeyuki Matsui; Kimitoshi Nishiwaki; Akihiko Usui

  General thoracic and cardiovascular surgery, Oct. 2021

  
• The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry.

  Yuma Yasuda; Mitsuaki Nishikimi; Kota Matsui; Atsushi Numaguchi; Kazuki Nishida; Ryo Emoto; Shigeyuki Matsui; Naoyuki Matsuda

  Resuscitation, 30 Sep. 2021

  
• Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock.

  Hiroaki Hiraiwa; Daisuke Kasugai; Masayuki Ozaki; Yukari Goto; Naruhiro Jingushi; Michiko Higashi; Kazuki Nishida; Toru Kondo; Kenji Furusawa; Ryota Morimoto; Takahiro Okumura; Naoyuki Matsuda; Shigeyuki Matsui; Toyoaki Murohara

  Scientific reports, 22 Sep. 2021

  
• Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry.

  Mitsuaki Nishikimi; Takayuki Ogura; Kazuki Nishida; Kei Hayashida; Ryo Emoto; Shigeyuki Matsui; Naoyuki Matsuda; Taku Iwami

  Critical care medicine, Aug. 2021

  
• A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer.

  Masato Yoshihara; Ryo Emoto; Kazuhisa Kitami; Shohei Iyoshi; Kaname Uno; Kazumasa Mogi; Sho Tano; Nobuhisa Yoshikawa; Shigeyuki Matsui; Hiroaki Kajiyama

  Scientific reports, 26 Jul. 2021

  
• Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis

  Daisuke Kasugai; Masayuki Ozaki; Kazuki Nishida; Yukari Goto; Kunihiko Takahashi; Shigeyuki Matsui; Naoyuki Matsuda

  Scientific Reports, 07 Jul. 2021

  
• The interplay between bystander cardiopulmonary resuscitation and ambient temperature on neurological outcome after cardiac arrest: A nationwide observational cohort study.

  Kei Hayashida; Ryosuke Takegawa; Mitsuaki Nishikimi; Tomoaki Aoki; Ryo Emoto; Koichiro Shinozaki; Santiago J Miyara; Daniel M Rolston; Timmy Li; Muhammad Shoaib; Tatsuma Fukuda; Ernesto P Molmenti; Masaru Suzuki; Junichi Sasaki; Shigeyuki Matsui; Lance B Becker

  Resuscitation, Jul. 2021

  
• Semi-parametric empirical Bayes factor for genome-wide association studies

  Junji Morisawa; Takahiro Otani; Jo Nishino; Ryo Emoto; Kunihiko Takahashi; Shigeyuki Matsui

  European Journal of Human Genetics, May 2021

  
• Statistical Models in Clinical Studies

  Matsui Shigeyuki; Le-Rademacher Jennifer; Mandrekar Sumithra J

  JOURNAL OF THORACIC ONCOLOGY, May 2021

  
• Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality.

  Mitsuaki Nishikimi; Kazuki Nishida; Yuichiro Shindo; Muhammad Shoaib; Daisuke Kasugai; Yuma Yasuda; Michiko Higashi; Atsushi Numaguchi; Takanori Yamamoto; Shigeyuki Matsui; Naoyuki Matsuda

  PloS one, 30 Apr. 2021

  
• Blinded Sample Size Re-Estimation in Comparative Clinical Trials With Overdispersed Count Data: Incorporation of Misspecification of the Variance Function

  Masataka Igeta; Shigeyuki Matsui

  STATISTICS IN BIOPHARMACEUTICAL RESEARCH, 03 Apr. 2021

  
• Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial).

  Hideki Ueno; Megumi Ishiguro; Eiji Nakatani; Toshiaki Ishikawa; Hiroyuki Uetake; Kenta Murotani; Shigeyuki Matsui; Satoshi Teramukai; Tamotsu Sugai; Yoichi Ajioka; Hirotoshi Maruo; Masahito Kotaka; Masaki Tsujie; Yoshinori Munemoto; Takashi Yamaguchi; Hisashi Kuroda; Mutsumi Fukunaga; Naohiro Tomita; Kenichi Sugihara

  British journal of cancer, 16 Mar. 2021

  
• Does complete-staging lymphadenectomy improve survival outcomes in stage I endometrioid epithelial ovarian carcinoma? A multi-institutional retrospective study with propensity score-weighted analysis.

  Masato Yoshihara; Satoshi Tamauchi; Shohei Iyoshi; Kazuhisa Kitami; Kaname Uno; Sho Tano; Shigeyuki Matsui; Hiroaki Kajiyama

  Japanese journal of clinical oncology, Mar. 2021

  
• Effect-Size Estimation Using Semiparametric Hierarchical Mixture Models in Disease-Association Studies with Neuroimaging Data

  Ryo Emoto; Atsushi Kawaguchi; Kunihiko Takahashi; Shigeyuki Matsui

  Computational and Mathematical Methods in Medicine, 09 Dec. 2020

  
• Relationship Between Bone Mineral Density and Risk of Vertebral Fractures with Denosumab Treatment in Japanese Postmenopausal Women and Men with Osteoporosis

  Okubo Naoki; Matsui Shigeyuki; Matsumoto Toshio; Sugimoto Toshitsugu; Hosoi Takayuki; Osakabe Taisuke; Watanabe Ko; Takami Hideo; Shiraki Masataka; Nakamura Toshitaka

  CALCIFIED TISSUE INTERNATIONAL, Dec. 2020

  
• Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer: Prospective Validation in a Randomized Controlled Study (SACURA Trial).

  Hideki Ueno; Megumi Ishiguro; Eiji Nakatani; Toshiaki Ishikawa; Hiroyuki Uetake; Shigeyuki Matsui; Satoshi Teramukai; Kenta Murotani; Yoichi Ajioka; Hideyuki Shimazaki; Atsuyuki Maeda; Kunio Takuma; Takefumi Yoshida; Takeshi Kambara; Keiji Matsuda; Akinori Takagane; Naohiro Tomita; Kenichi Sugihara

  The American journal of surgical pathology, Dec. 2020

  
• The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.

  Shogo Kumagai; Yosuke Togashi; Takahiro Kamada; Eri Sugiyama; Hitomi Nishinakamura; Yoshiko Takeuchi; Kochin Vitaly; Kota Itahashi; Yuka Maeda; Shigeyuki Matsui; Takuma Shibahara; Yasuho Yamashita; Takuma Irie; Ayaka Tsuge; Shota Fukuoka; Akihito Kawazoe; Hibiki Udagawa; Keisuke Kirita; Keiju Aokage; Genichiro Ishii; Takeshi Kuwata; Kenta Nakama; Masahito Kawazu; Toshihide Ueno; Naoya Yamazaki; Koichi Goto; Masahiro Tsuboi; Hiroyuki Mano; Toshihiko Doi; Kohei Shitara; Hiroyoshi Nishikawa

  Nature immunology, Nov. 2020

  
• Desmoid with biweekly methotrexate and vinblastine shows similar effects to weekly administration: A phase II clinical trial

  Nishida Yoshihiro; Hamada Shunsuke; Urakawa Hiroshi; Ikuta Kunihiro; Sakai Tomohisa; Koike Hiroshi; Ito Kan; Emoto Ryo; Ando Yuichi; Matsui Shigeyuki

  CANCER SCIENCE, Nov. 2020

  
• Impact of uterus‐preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi‐institutional study with propensity score‐weighted analysis

  Masato Yoshihara; Hiroaki Kajiyama; Satoshi Tamauchi; Shohei Iyoshi; Akira Yokoi; Shiro Suzuki; Michiyasu Kawai; Tetsuro Nagasaka; Kunihiko Takahashi; Shigeyuki Matsui; Fumitaka Kikkawa

  International Journal of Gynecology & Obstetrics, Aug. 2020

  
• High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study.

  Norihito Omote; Naoyuki Matsuda; Naozumi Hashimoto; Kazuki Nishida; Koji Sakamoto; Akira Ando; Yoshio Nakahara; Mitsuaki Nishikimi; Michiko Higashi; Shigeyuki Matsui; Yoshinori Hasegawa

  Nagoya journal of medical science, May 2020

  
• A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial

  Fujii Tasuku; Shibata Yasuyuki; Ban Yasutaka; Shitaokoshi Akira; Takahashi Kunihiko; Matsui Shigeyuki; Nishiwaki Kimitoshi

  JOURNAL OF ANESTHESIA, Feb. 2020

  
• More Powerful Selective Kernel Tests for Feature Selection.

  Jen Ning Lim; Makoto Yamada; Wittawat Jitkrittum; Yoshikazu Terada; Shigeyuki Matsui; Hidetoshi Shimodaira

  The 23rd International Conference on Artificial Intelligence and Statistics(AISTATS), 2020

  
• Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis

  Yoshihara M; Kajiyama H; Tamauchi S; Iyoshi S; Yokoi A; Suzuki S; Kawai M; Nagasaka T; Takahashi K; Matsui S; Kikkawa F

  Japanese Journal of Clinical Oncology, 2020, Peer-reviewed

  
• Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion

  Takagi H; Hagiwara D; Handa T; Sugiyama M; Onoue T; Tsunekawa T; Ito Y; Iwama S; Goto M; Suga H; Banno R; Takahashi K; Matsui S; Arima H

  Endocrine Journal, 2020, Peer-reviewed

  
• Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial

  Yasuda Y; Nishikimi M; Nishida K; Takahashi K; Numaguchi A; Higashi M; Matsui S; Matsuda N

  Critical Care Explorations, 2020, Peer-reviewed

  
• Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis.

  Masato Yoshihara; Hiroaki Kajiyama; Satoshi Tamauchi; Shiro Suzuki; Kunihiko Takahashi; Shigeyuki Matsui; Fumitaka Kikkawa

  Journal of gynecologic oncology, Nov. 2019

  
• Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial.

  Hideki Ueno; Megumi Ishiguro; Eiji Nakatani; Toshiaki Ishikawa; Hiroyuki Uetake; Chu Matsuda; Yoshihiko Nakamoto; Masanori Kotake; Kiyotaka Kurachi; Tomohisa Egawa; Keigo Yasumasa; Kohei Murata; Osamu Ikawa; Seiichi Shinji; Kenta Murotani; Shigeyuki Matsui; Satoshi Teramukai; Naohiro Tomita; Kenichi Sugihara

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 01 Aug. 2019, Peer-reviewed

  
• Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials.

  Takahiro Nonaka; Masataka Igeta; Shigeyuki Matsui

  Pharmaceutical statistics, Jul. 2019

  
• Novel multi-gene classifier for prediction of relapse-free survival after FU-based adjuvant chemotherapy for stage III colon cancer: A biomarker study of the ACTS-C trial, a randomized controlled study

  Ishikawa Toshiaki; Murotani Kenta; Ishiguro Megumi; Nakatani Eiji; Uetake Hiroyuki; Matsui Shigeyuki; Sugihara Kenichi

  CANCER RESEARCH, Jul. 2019

  
• External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management.

  Nishikimi M; Ogura T; Nishida K; Takahashi K; Nakamura M; Matsui S; Matsuda N; Iwami T

  Resuscitation, 30 May 2019

  Access this paper :

  
• Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study

  Kasugai Daisuke; Nishikimi Mitsuaki; Nishida Kazuki; Higashi Michiko; Yamamoto Takanori; Numaguchi Atsushi; Takahashi Kunihiko; Matsui Shigeyuki; Matsuda Naoyuki

  JOURNAL OF INTENSIVE CARE, 05 Apr. 2019

  
• Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells

  Yoshio Sakai; Masao Honda; Shigeyuki Matsui; Osamu Komori; Toshinori Murayama; Tadami Fujiwara; Masaaki Mizuno; Yasuhito Imai; Kenichi Yoshimura; Alessandro Nasti; Takashi Wada; Noriho Iida; Masaaki Kitahara; Rika Horii; Tamai Toshikatsu; Masashi Nishikawa; Hirofumi Okafuji; Eishiro Mizukoshi; Tatsuya Yamashita; Taro Yamashita; Kuniaki Arai; Kazuya Kitamura; Kazunori Kawaguchi; Hajime Takatori; Tetsuro Shimakami; Takeshi Terashima; Tomoyuki Hayashi; Kouki Nio; Shuichi Kaneko

  Cancer Science, Apr. 2019

  
• [Na+] Increases in body fluids sensed by central Nax induce sympathetically mediated blood pressure elevations via H+-dependent activation of ASIC1a

  Nomura K; Hiyama TY; Sakuta H; Matsuda T; Lin CH; Kobayashi K; Kobayashi K; Kuwaki T; Takahashi K; Matsui S; Noda M

  Neuron, 02 Jan. 2019, Peer-reviewed

  
• More Powerful Selective Kernel Tests for Feature Selection.

  Jen Ning Lim; Makoto Yamada; Wittawat Jitkrittum; Yoshikazu Terada; Shigeyuki Matsui; Hidetoshi Shimodaira

  CoRR, 2019, Peer-reviewed

  
• Rule-Based Designs Considering Toxicity Alone

  Daimon Takashi; Hirakawa Akihiro; Matsui Shigeyuki

  DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE, 2019

  
• Model-Based Designs Considering Toxicity Alone

  Daimon Takashi; Hirakawa Akihiro; Matsui Shigeyuki

  DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE, 2019

  
• Model-Assisted Designs Considering Toxicity Alone

  Daimon Takashi; Hirakawa Akihiro; Matsui Shigeyuki

  DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE, 2019

  
• Early-Phase Cancer Clinical Trials

  Daimon Takashi; Hirakawa Akihiro; Matsui Shigeyuki

  DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE, 2019

  
• Dose-Finding Designs for Early-Phase Cancer Clinical Trials A Brief Guidebook to Theory and Practice Preface

  Daimon Takashi; Hirakawa Akihiro; Matsui Shigeyuki

  DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE, 2019

  
• Designs for Early-Phase Immunotherapeutic Agent Trials

  Daimon Takashi; Hirakawa Akihiro; Matsui Shigeyuki

  DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE, 2019

  
• Designs Considering Toxicity and Efficacy

  Daimon Takashi; Hirakawa Akihiro; Matsui Shigeyuki

  DOSE-FINDING DESIGNS FOR EARLY-PHASE CANCER CLINICAL TRIALS: A BRIEF GUIDEBOOK TO THEORY AND PRACTICE, 2019

  
• Application of the Multi-Dimensional Hierarchical Mixture Model to Cross-Disorder Genome-Wide Association Studies

  Otani Takahiro; Nishino Jo; Emoto Ryo; Matsui Shigeyuki

  16TH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY-NEW GENERATIONS (ITNG 2019), 2019

  
• A New Scoring System for Predicting Adverse Events in Hospitalized Patients with Community-Onset Pneumonia

  Sakakibara T; Shindo Y; Takahashi K; Kobayashi D; Okumura J; Sano M; Murakami Y; Thabet N; Kobayashi H; Yagi T; Matsui S; Saka H; Hasegawa Y

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019

  
• A Model-Based Framework for Voxel and Region Level Inferences in Neuroimaging Disease-Association Studies

  Emoto Ryo; Kawaguchi Atsushi; Otani Takahiro; Matsui Shigeyuki

  16TH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY-NEW GENERATIONS (ITNG 2019), 2019

  
• Exploring predictive biomarkers from clinical genome-wide association studies via multidimensional hierarchical mixture models.

  Otani T; Noma H; Sugasawa S; Kuchiba A; Goto A; Yamaji T; Kochi Y; Iwasaki M; Matsui S; Tsunoda T

  European Journal of Human Genetics, Jan. 2019, Peer-reviewed

  
• compound.Cox: univariate feature selection and compound covariate for predicting survival.

  Emura T; Matsui S; Chen HY

  Computer Methods and Programs in Biomedicine, Jan. 2019, Peer-reviewed

  
• Clinical frailty scale score before ICU admission is associated with mobility disability in septic patients receiving early rehebilitation

  Nakajima H; Nishikimi M; Shimizu M; Hayashi K; Inoue T; Nishida K; Takahashi K; Matsui S; Nishida Y; Matsuda N

  Critical Care Explorations, 2019, Peer-reviewed

  
• A randomised controlled trial of pectoralis nerves-2 (PECS 2) block versus serratus plane block for chronic pain after mastectomy

  Fujii T; Shibata Y; Akane A; Aoki W; Sekiguchi A; Takahashi K; Matsui S; Nishiwaki K

  Anaesthesia, 2019, Peer-reviewed

  
• Steeper macular curvature in eyes with non-highly myopic retinitis pigmentosa

  Komori S; Ueno S; Ito Y; Sayo A; Meinert M; Kominami T; Inooka D; Kitagawa M; Nishida K; Takahashi K; Matsui S; Terasaki H

  Investigative Ophthalmology & Visual Science, 2019, Peer-reviewed

  
• Maximum norepinephrine dosage within 24 hours as an indicator of refractory septic shock: a retrospective study

  Kasugai D; Hirakawa A; Ozaki M; Nishida K; Ikeda T; Takahashi K; Matsui S; Uenishi N

  Journal of Intensive Care Medicine, 2019, Peer-reviewed

  
• Two-stage analysis for selecting fixed numbers of features in omics association studies

  Kawabata T; Emoto R; Nishino J; Takahashi K; Matsui S

  Statistics in Medicine, 2019, Peer-reviewed

  
• The authors reply

  Mitsuaki Nishikimi; Atsushi Numaguchi; Kunihiko Takahashi; Shigeyuki Matsui; Naoyuki Matsuda

  Critical Care Medicine, Dec. 2018

  
• Comprehensive Search for Prognostic Biomarkers using PCAWG Data

  Mamoru Kato; Momoko Nagai; Takanori Hasegawa; Seiya Imoto; Shigeyuki Matsui; Tatsuhiko Tsunoda; Tatsuhiro Shibata

  CANCER SCIENCE, Dec. 2018

  
• Sleep, the Missing Link? Reply

  Nishikimi Mitsuaki; Numaguchi Atsushi; Takahashi Kunihiko; Matsui Shigeyuki; Matsuda Naoyuki

  CRITICAL CARE MEDICINE, Dec. 2018

  
• Two-stage approach based on zone and dose findings for two-agent combination Phase I/II trials

  Shimamura Fumiya; Hamada Chikuma; Matsui Shigeyuki; Hirakawa Akihiro

  JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 02 Nov. 2018

  
• Prognostic impact of MSI and 18qLOH in stage II colon cancer: A prospective biomarker study in the SACURA trial

  Ishikawa T; Ishiguro M; Nakatani E; Ueno H; Uetake H; Murotani K; Matsui S; Tomita N; Shimada Y; Takahashi K; Kotake K; Watanabe M; Mochizuki H; Teramukai S; Sugihara K

  ANNALS OF ONCOLOGY, Oct. 2018

  
• Early Administration of Ramelteon in the ICU: Effects Deserve Further Study Reply

  Nishikimi Mitsuaki; Numaguchi Atsushi; Takahashi Kunihiko; Matsui Shigeyuki; Matsuda Naoyuki

  CRITICAL CARE MEDICINE, Oct. 2018

  
• Personalized dynamic prediction of death according to tumour progression and high-dimensional genetic factors: Meta-analysis with a joint model.

  Emura T; Nakatochi M; Matsui S; Michimae H; Rondeau V

  Statistical Methods in Medical Research, Sep. 2018, Peer-reviewed

  
• Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice.

  Satomi Funahashi; Yasumasa Okazaki; Takahiro Nishiyama; Hidekazu Ohyoshi; Hiroyuki Yasui; Kazuki Nishida; Shigeyuki Matsui; Shinya Toyokuni

  Free radical research, Sep. 2018, Peer-reviewed

  
• Preoperative six-minute walk distance is associated with postoperative cognitive dysfunction.

  Hayashi K; Oshima H; Shimizu M; Kobayashi K; Matsui S; Nishida Y; Usui A

  Annals of Thoracic Surgery, Aug. 2018, Peer-reviewed

  
• Re-assessment of multiple testing strategies for more efficient genome-wide association studies.

  Otani T; Noma H; Nishino J; Matsui S

  European Journal of Human Genetics, Jul. 2018, Peer-reviewed

  
• Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial

  Nishikimi Mitsuaki; Numaguchi Atsushi; Takahashi Kunihiko; Miyagawa Yasuhiro; Matsui Kota; Higashi Michiko; Makishi Go; Matsui Shigeyuki; Matsuda Naoyuki

  CRITICAL CARE MEDICINE, Jul. 2018

  
• Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome

  Nishikimi Mitsuaki; Ogura Takayuki; Nishida Kazuki; Takahashi Kunihiko; Fukaya Kenji; Liu Keibun; Nakamura Mitsunobu; Matsui Shigeyuki; Matsuda Naoyuki

  RESUSCITATION, Jul. 2018

  
• Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder.

  Jo Nishino; Hidenori Ochi; Yuta Kochi; Tatsuhiko Tsunoda; Shigeyuki Matsui

  Frontiers in genetics, 28 Jun. 2018

  
• The current state of therapeutic development for rare cancers in Japan, and proposals for improvement.

  Kawai A; Goto T; Shibata T; Tani K; Mizutani S; Nishikawa A; Shibata T; Matsumoto S; Nagata K; Narukawa M; Matsui S; Ando M; Toguchida J; Monden M; Heike T; Kimura S; Ueda R

  Cancer Science, May 2018, Peer-reviewed

  
• Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department

  Nishikimi Mitsuaki; Ogura Takayuki; Matsui Kota; Takahashi Kunihiko; Fukaya Kenji; Liu Keibun; Morita Hideo; Nakamura Mitsunobu; Matsui Shigeyuki; Matsuda Naoyuki

  JOURNAL OF INTENSIVE CARE, 25 Apr. 2018

  
• Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures.

  Nishino J; Kochi Y; Shigemizu D; Kato M; Ikari K; Ochi H; Noma H; Matsui K; Morizono T; Boroevich K; Tsunoda T; Matsui S

  Frontiers in Genetics, 24 Apr. 2018, Peer-reviewed

  
• Biomarker-Stratified Phase III Clinical Trials: Enhancement with a Subgroup-Focused Sequential Design

  Matsui Shigeyuki; Crowley John

  CLINICAL CANCER RESEARCH, 01 Mar. 2018

  
• Multi-subgroup gene screening using semi-parametric hierarchical mixture models and the optimal discovery procedure: application to a randomized clinical trial in multiple myeloma

  Matsui, S; Noma, H; Qu, P; Sakai, Y; Matsui, K; Heuck, C; Crowley, J

  Biometrics, Mar. 2018, Peer-reviewed

  
• Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents Preface

  Hirakawa Akihiro; Sato Hiroyuki; Daimon Takashi; Matsui Shigeyuki

  MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS, 2018

  
• Dose Finding in Phase I Cancer Trials

  Hirakawa Akihiro; Sato Hiroyuki; Daimon Takashi; Matsui Shigeyuki

  MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS, 2018

  
• Dose Finding for Molecularly Targeted Agents (MTAs)

  Hirakawa Akihiro; Sato Hiroyuki; Daimon Takashi; Matsui Shigeyuki

  MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS, 2018

  
• Dose Finding for Joint Assessment of Both Efficacy and Toxicity

  Hirakawa Akihiro; Sato Hiroyuki; Daimon Takashi; Matsui Shigeyuki

  MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS, 2018

  
• Dose Finding for a Combination of Two Agents

  Hirakawa Akihiro; Sato Hiroyuki; Daimon Takashi; Matsui Shigeyuki

  MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS, 2018

  
• Advanced Topics on Dose-Finding Designs

  Hirakawa Akihiro; Sato Hiroyuki; Daimon Takashi; Matsui Shigeyuki

  MODERN DOSE-FINDING DESIGNS FOR CANCER PHASE I TRIALS: DRUG COMBINATIONS AND MOLECULARLY TARGETED AGENTS, 2018

  
• Immune condition of colorectal cancer patients featured by serum chemokines and gene expressions of CD4+ cells in blood.

  Komura T; Yano M; Miyake A; Takabatake H; Miyazawa M; Ogawa N; Seki A; Honda M; Wada T; Matsui S; Kaneko S; Sakai Y

  Canadian Journal of Gastroenterology and Hepatology, 2018, Peer-reviewed

  
• Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of β-lactam plus macrolide combination therapy

  Okumura J; Shindo Y; Takahashi K; Sano M; Sugino Y; Yagi T; Taniguchi H; Saka H; Matsui S; Hasegawa Y

  Respirology, 2018, Peer-reviewed

  
• Treatment of patients with sepsis in a closed Intensive Care Unit is associated with improved survival: A nationwide observational study in Japan

  Ogura T; Nakamura Y; Takahashi K; Nishida K; Kobashi D; Matsui S

  Journal of Intensive Care, 2018, Peer-reviewed

  
• Power and sample size calculation incorporating misspecifications of the variance function in comparative clinical trials with over-dispersed count data

  Igeta M; Takahashi K; Matsui S

  Biometrics, 2018, Peer-reviewed

  
• A dose-response meta-analysis of coffee consumption and colorectal cancer risk in the Japanese population: application of a cubic-spline model

  Horisaki K; Takahashi K; Ito H; Matsui S

  Journal of Epidemiology, 2018, Peer-reviewed

  
• High-Flow Nasal Cannula Therapy for Acute Respiratory Failure in Patients with Interstitial Pneumonia: A Retrospective Observational Study

  Omote N; Hashimoto N; Matsuda N; Nishida K; Sakamoto K; Ando A; Nakahara Y; Nishikimi M; Higashi M; Matsui S; Hasegawa Y

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018

  
• IMPLICATION OF beta-LACTAM PLUS MACROLIDE COMBINATION THERAPY ON MORTALITY IN PATIENTS WITH COMMUNITY-ONSET PNEUMONIA AT LOW RISK FOR DRUG-RESISTANT PATHOGENS

  Okumura Junya; Shindo Yuichiro; Sano Masahiro; Sakakibara Toshihiro; Matsuda Toshiaki; Takahashi Kunihiko; Saka Hideo; Matsui Shigeyuki; Hasegawa Yoshinori

  RESPIROLOGY, Nov. 2017

  
• Risk Factors For Severe Adverse Outcomes In Patients With Hospital-Acquired Pneumonia

  Sano M; Shindo Y; Okumura J; Sakakibara T; Matsuda T; Yagi T; Matsui K; Takahashi K; Matsui S; Hasegawa Y

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017

  
• Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow.

  Iwase T; Yamamoto K; Ra E; Murotani K; Matsui S; Terasaki H

  Medicine (Baltimore)., 2015, Peer-reviewed

  
• Idiopathic sudden sensorineural hearing loss in Japan.

  Nakashima T; Sato H; Gyo K; Hato N; Yoshida T; Shimono M; Teranishi M; Sone M; Fukunaga Y; Kobashi G; Takahashi K; Matsui S; Ogawa K

  Acta oto-laryngologica, Nov. 2014, Peer-reviewed

  
• Dose-finding methods for two-agent combination phase i trials

  Akihiro Hirakawa; Shigeyuki Matsui

  Developments in Statistical Evaluation of Clinical Trials, 01 Apr. 2014, Peer-reviewed

  
• Endoscopic evaluation of low-dose aspirin-induced gastric and duodenal ulcers during prophylaxis with lansoprazole.

  Nobuhiro Sakaki; Kiyoshi Ashida; Yuji Mizokami; Tsutomu Chiba; Shigeyuki Matsui; Tatsuya Kanto; Naomi Uemura; Naoki Hiramatsu; Kentaro Sugano

  Hepato-gastroenterology, Jun. 2013, Peer-reviewed

  
• Bayesian Ranking and Selection Methods in Microarray Studies

  Hisashi Noma; Shigeyuki Matsui

  Statistical Diagnostics for Cancer: Analyzing High-Dimensional Data, 08 Apr. 2013

  
• PP-816 SNPアレイを用いた転移性前立腺癌の生存期間に関与する癌関連遺伝子の探索(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

  土谷 順彦; 成田 伸太郎; 井上 高光; 鶴田 大; 沼倉 一幸; 堀川 洋平; 畠山 真吾; 大山 力; 荒井 陽一; 小川 修; 斎藤 誠一; 松井 茂之; 羽渕 友則

  日本泌尿器科学会雑誌, 2011

  
• Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling

  Noriomi Matsumura; Masaki Mandai; Takako Okamoto; Ken Yamaguchi; Shogo Yamamura; Tomonori Oura; Tsukasa Baba; Junzo Hamanishi; Hyun S. Kang; Shigeyuki Matsui; Seiichi Mori; Susan K. Murphy; Ikuo Konishi

  CANCER SCIENCE, Dec. 2010, Peer-reviewed

  
• Statistical Analysis of Microarray Data : How to Avoid Pitfalls

  MATSUI Shigeyuki

  KAGAKU TO SEIBUTSU, 01 Nov. 2008

  
• Comments on Points to Consider on Missing Data

  MATSUI Shigeyuki

  Japanese Journal of Biometrics, 30 Sep. 2006

  
• Lessons from gefitinib-induced interstitial lung disease in Japan: Problems in approval, pharmacovigilance, and regulatory decision-making procedures

  Tsutomu Nishimura; Harue Tada; Masatsugu Nakagawa; Satoshi Teramukai; Shigeyuki Matsui; Masanori Fukushima

  Pharmacy Practice, 2006

  
• Summary

  Matsui Shigeyuki

  Japanese Journal of Biometrics, 2006

  

Misc.

• Prediction of survival in patients with metastatic prostate cancer by single nucleotide polymorphisms of cancer-associated genes.

  Takamitsu Inoue; Norihiko Tsuchiya; Shigeyuki Matsui; Tomomi Kamba; Koji Mitsuzuka; Shingo Hatakeyama; Yohei Horikawa; Chikara Ohyama; Seiichi Saito; Yoichi Arai; Osamu Ogawa; Tomonori Habuchi

  JOURNAL OF CLINICAL ONCOLOGY, Feb. 2012

  
• 初期粘液性卵巣癌における系統的リンパ節郭清の意義 プロペンシティスコア解析

  茂木 一将; 吉原 雅人; 玉内 学志; 伊吉 祥平; 横井 暁; 河井 通泰; 長坂 徹郎; 高橋 邦彦; 松井 茂之; 梶山 広明

  日本癌治療学会学術集会抄録集, Oct. 2021

  
• Stage II結腸癌における18qCIN(Chromosomal Instability)と予後の検討 SACURA試験バイオマーカー研究

  石川 敏昭; 中谷 英仁; 石黒 めぐみ; 上野 秀樹; 室谷 健太; 松井 茂之; 手良向 聡; 植竹 宏之; 冨田 尚裕; 杉原 健一; SACURA Study Group

  日本大腸肛門病学会雑誌, May 2019

  
• Stage II結腸癌における18qCIN(Chromosomal Instability)と予後の検討 SACURA試験バイオマーカー研究

  石川 敏昭; 中谷 英仁; 石黒 めぐみ; 上野 秀樹; 室谷 健太; 松井 茂之; 手良向 聡; 植竹 宏之; 冨田 尚裕; 杉原 健一; SACURA Study Group

  日本大腸肛門病学会雑誌, May 2019

  
• Stage II結腸癌における18qCIN(Chromosomal Instability)と予後の検討~SACURA試験バイオマーカー研究

  石川敏昭; 中谷英仁; 石黒めぐみ; 上野秀樹; 室谷健太; 松井茂之; 手良向聡; 植竹宏之; 冨田尚裕; 杉原健一

  日本大腸肛門病学会雑誌(Web), 2019

  
• The authors reply

  Mitsuaki Nishikimi; Atsushi Numaguchi; Kunihiko Takahashi; Shigeyuki Matsui; Naoyuki Matsuda

  Critical care medicine, 01 Oct. 2018

  
• オミクス研究における検証的解析と探索的解析：多重検定とP値を中心に

  松井 茂之

  計量生物学, 2018, Peer-reviewed

  
• Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa

  Akira Sayo; Shinji Ueno; Taro Kominami; Kazuki Nishida; Daiki Inooka; Ayami Nakanishi; Shunsuke Yasuda; Satoshi Okado; Kunihiko Takahashi; Shigeyuki Matsui; Hiroko Terasaki

  SCIENTIFIC REPORTS, Nov. 2017, Peer-reviewed

  
• Frontiers of biostatistical methods and applications in clinical oncology

  Shigeyuki Matsui; John Crowley

  Frontiers of Biostatistical Methods and Applications in Clinical Oncology, 03 Oct. 2017

  
• ハイリスクStage II大腸癌の治療戦略 Stage II結腸癌における再発リスクの層別と治療戦略の展望 SACURA trialの結果から

  石黒 めぐみ; 上野 秀樹; 石川 敏昭; 中谷 英仁; 手良向 聡; 松井 茂之; 室谷 健太; 望月 英隆; 固武 健二郎; 高橋 慶一; 渡邊 昌彦; 島田 安博; 冨田 尚裕; 植竹 宏之; 杉原 健一

  日本臨床外科学会雑誌, Oct. 2017

  
• 臨床応用を目指した消化器外科領域の基礎研究・橋渡し研究 Stage II結腸癌に対する術後補助化学療法の第III相試験(SACURA trial)におけるMSIと予後の検討

  石川 敏昭; 植竹 宏之; 石黒 めぐみ; 室谷 健太; 上野 秀樹; 松井 茂之; 中谷 英仁; 手良向 聡; 冨田 尚裕; 杉原 健一

  日本消化器外科学会総会, Jul. 2017

  
• Stage II結腸癌におけるdesmoplastic reaction分類の臨床的意義 SACURA trialにおける前向き付随研究

  上野 秀樹; 石黒 めぐみ; 石川 敏昭; 中谷 英仁; 室谷 健太; 松井 茂之; 手良向 聡; 植竹 宏之; 冨田 尚裕; 杉原 健一

  日本消化器外科学会総会, Jul. 2017

  
• 臨床応用を目指した消化器外科領域の基礎研究・橋渡し研究 Stage II結腸癌に対する術後補助化学療法の第III相試験(SACURA trial)におけるMSIと予後の検討

  石川 敏昭; 植竹 宏之; 石黒 めぐみ; 室谷 健太; 上野 秀樹; 松井 茂之; 中谷 英仁; 手良向 聡; 冨田 尚裕; 杉原 健一

  日本消化器外科学会総会, Jul. 2017

  
• Stage II結腸癌におけるdesmoplastic reaction分類の臨床的意義 SACURA trialにおける前向き付随研究

  上野 秀樹; 石黒 めぐみ; 石川 敏昭; 中谷 英仁; 室谷 健太; 松井 茂之; 手良向 聡; 植竹 宏之; 冨田 尚裕; 杉原 健一

  日本消化器外科学会総会, Jul. 2017

  
• わが国におけるStage II、III結腸癌に対する術後補助化学療法のバイオマーカー探索 SACURA trialとACTS-CC trialより

  植竹 宏之; 石川 敏昭; 石黒 めぐみ; 上野 秀樹; 松井 茂之; 室谷 健太; 中谷 英仁; 手良向 聡; 冨田 尚裕; 杉原 健一

  日本消化器外科学会総会, Jul. 2017

  
• わが国におけるStage II、III結腸癌に対する術後補助化学療法のバイオマーカー探索 SACURA trialとACTS-CC trialより

  植竹 宏之; 石川 敏昭; 石黒 めぐみ; 上野 秀樹; 松井 茂之; 室谷 健太; 中谷 英仁; 手良向 聡; 冨田 尚裕; 杉原 健一

  日本消化器外科学会総会, Jul. 2017

  
• Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus

  Maki Takagishi; Masato Sawada; Shinya Ohata; Naoya Asai; Atsushi Enomoto; Kunihiko Takahashi; Liang Weng; Kaori Ushida; Hosne Ara; Shigeyuki Matsui; Kozo Kaibuchi; Kazunobu Sawamoto; Masahide Takahashi

  CELL REPORTS, Jul. 2017, Peer-reviewed

  
• An efficient and flexible test for rare variant effects

  Shonosuke Sugasawa; Hisashi Noma; Takahiro Otani; Jo Nishino; Shigeyuki Matsui

  EUROPEAN JOURNAL OF HUMAN GENETICS, Jun. 2017, Peer-reviewed

  
• Prognostic impact of tumor budding in stage II colon cancer: A prospective study (SACURA trial).

  Hideki Ueno; Megumi Ishiguro; Eiji Nakatani; Toshiaki Ishikawa; Hiroyuki Uetake; Kenta Murotani; Shigeyuki Matsui; Naohiro Tomita; Yasuhiro Shimada; Keiichi Takahashi; Kenjiro Kotake; Masahiko Watanabe; Hidetaka Mochizuki; Satoshi Teramukai; Kenichi Sugihara

  JOURNAL OF CLINICAL ONCOLOGY, May 2017

  
• Prognostic impact of MSI in stage II colon cancers: An additional translational study of the SACURA trial.

  Toshiaki Ishikawa; Megumi Ishiguro; Eiji Nakatani; Hiroyuki Uetake; Hideki Ueno; Kenta Murotani; Shigeyuki Matsui; Naohiro Tomita; Yasuhiro Shimada; Keiichi Takahashi; Kenjiro Kotake; Masahiko Watanabe; Hidetaka Mochizuki; Satoshi Teramukai; Kenichi Sugihara

  JOURNAL OF CLINICAL ONCOLOGY, May 2017

  
• A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score

  Mitsuaki Nishikimi; Naoyuki Matsuda; Kota Matsui; Kunihiko Takahashi; Tadashi Ejima; Keibun Liu; Takayuki Ogura; Michiko Higashi; Hitoshi Umino; Go Makishi; Atsushi Numaguchi; Satoru Matsushima; Hideki Tokuyama; Mitsunobu Nakamura; Shigeyuki Matsui

  SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE, May 2017, Peer-reviewed

  
• Quantifying indirect evidence in network meta-analysis

  Hisashi Noma; Shiro Tanaka; Shigeyuki Matsui; Andrea Cipriani; Toshi A. Furukawa

  STATISTICS IN MEDICINE, Mar. 2017, Peer-reviewed

  
• Stae II結腸癌における再発リスクの層別と治療戦略の展望~SACURA trialの結果から

  石黒めぐみ; 上野秀樹; 石川敏昭; 中谷英仁; 手良向聡; 松井茂之; 室谷健太; 望月英隆; 固武健二郎; 高橋慶一; 渡邊昌彦; 島田安博; 冨田尚裕; 植竹宏之; 杉原健一; 石黒めぐみ; 上野秀樹; 石川敏昭; 中谷英仁; 手良向聡; 松井茂之; 室谷健太; 望月英隆; 固武健二郎; 高橋慶一; 渡邊昌彦; 島田安博; 冨田尚裕; 植竹宏之; 杉原健一

  日本臨床外科学会雑誌, 2017

  
• Correcting Estimation Bias in Randomized Clinical Trials With a Test of Treatment-by-Biomarker Interaction

  Kiichiro Toyoizumi; Shigeyuki Matsui

  STATISTICS IN BIOPHARMACEUTICAL RESEARCH, 2017, Peer-reviewed

  
• CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy

  Mitsuaki Nishikimi; Naoyuki Matsuda; Kota Matsui; Kunihiko Takahashi; Tadashi Ejima; Keibun Liu; Takayuki Ogura; Michiko Higashi; Hitoshi Umino; Go Makishi; Atsushi Numaguchi; Satoru Matsushima; Hideki Tokuyama; Mitsunobu Nakamura; Shigeyuki Matsui

  INTENSIVE CARE MEDICINE, Dec. 2016, Peer-reviewed

  
• 消化器外科領域における最新のトランスレーショナルリサーチ Stage III結腸癌におけるDNAコピー数変化と無再発生存期間の関連 ACTS-CC試験のバイオマーカー探索

  石川 敏昭; 植竹 宏之; 石黒 めぐみ; 室谷 健太; 中谷 英仁; 小武内 尚; 松井 茂之; 杉原 健一

  日本消化器外科学会総会, Jul. 2016

  
• 消化器外科領域における最新のトランスレーショナルリサーチ Stage III結腸癌におけるDNAコピー数変化と無再発生存期間の関連 ACTS-CC試験のバイオマーカー探索

  石川 敏昭; 植竹 宏之; 石黒 めぐみ; 室谷 健太; 中谷 英仁; 小武内 尚; 松井 茂之; 杉原 健一

  日本消化器外科学会総会, Jul. 2016

  
• Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment

  Misato Kobayashi; Takeshi Iwase; Kentaro Yamamoto; Eimei Ra; Kenta Murotani; Shigeyuki Matsui; Hiroko Terasaki

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Mar. 2016, Peer-reviewed

  
• Genome-wide DNA Copy-number Analysis in ACTS-CC Trial of Adjuvant Chemotherapy for Stage III Colonic Cancer

  Toshiaki Ishikawa; Hiroyuki Uetake; Kenta Murotani; Takashi Kobunai; Megumi Ishiguro; Shigeyuki Matsui; Kenichi Sugihara

  ANTICANCER RESEARCH, Mar. 2016, Peer-reviewed

  
• Operative wound-related complications after cranial revascularization surgeries

  Keisuke Takanari; Yoshio Araki; Sho Okamoto; Hideyoshi Sato; Shunjiro Yagi; Kazuhiro Toriyama; Kinya Yokoyama; Kenta Murotani; Shigeyuki Matsui; Toshihiko Wakabayashi; Yuzuru Kamei

  JOURNAL OF NEUROSURGERY, Nov. 2015, Peer-reviewed

  
• A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies

  Akihiro Hirakawa; Nolan A. Wages; Hiroyuki Sato; Shigeyuki Matsui

  STATISTICS IN MEDICINE, Oct. 2015, Peer-reviewed

  
• MSI, 18q LOH, and clinicopathological features in stage II sporadic colon cancers: Biomarker study in a phase III study of postoperative adjuvant chemotherapy for stage II colon cancer (SACURA trial)

  Toshiaki Ishikawa; Hiroyuki Uetake; Megumi Ishiguro; Kenta Murotani; Hideki Ueno; Shigeyuki Matsui; Kenichi Sugihara; Naohiro Tomita

  CANCER RESEARCH, Aug. 2015

  
• 大腸腫瘍と遺伝・遺伝子 Stage II結腸癌術後補助化学療法の第III相試験(SACURA試験)におけるMSI・18qLOHと臨床病理学的因子の相関

  石川 敏昭; 植竹 宏之; 石黒 めぐみ; 室谷 健太; 上野 秀樹; 松井 茂之; 杉原 健一; 冨田 尚裕

  日本消化器外科学会総会, Jul. 2015

  
• Sex-Related Differences in Ocular Blood Flow of Healthy Subjects Using Laser Speckle Flowgraphy

  Kosei Yanagida; Takeshi Iwase; Kentaro Yamamoto; Eimei Ra; Hiroki Kaneko; Kenta Murotani; Shigeyuki Matsui; Hiroko Terasaki

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Jul. 2015, Peer-reviewed

  
• Estimation of Treatment Effects in All-Comers Randomized Clinical Trials with a Predictive Marker

  Yuki Choai; Shigeyuki Matsui

  BIOMETRICS, Mar. 2015, Peer-reviewed

  
• Operating characteristics of restrictions on skipping dose level for adaptive dose-finding method in two-agent phase I trials

  Hirakawa A; Matsui S

  Japanese Journal of Biometrics 2015, 2015

  
• Idiopathic sudden sensorineural hearing loss in Japan.

  Nakashima T; Sato H; Gyo K; Hato N; Yoshida T; Shimono M; Teranishi M; Sone M; Fukunaga Y; Kobashi G; Takahashi K; Matsui S; Ogawa K

  Acta Otolaryngol, Nov. 2014, Peer-reviewed

  
• Clinical Trials Express: Fracture Risk Reduction With Denosumab in Japanese Postmenopausal Women and Men With Osteoporosis: Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT)

  Toshitaka Nakamura; Toshio Matsumoto; Toshitsugu Sugimoto; Takayuki Hosoi; Takami Miki; Itsuo Gorai; Hideki Yoshikawa; Yoshiya Tanaka; Sakae Tanaka; Teruki Sone; Tetsuo Nakano; Masako Ito; Shigeyuki Matsui; Toshiyuki Yoneda; Hideo Takami; Ko Watanabe; Taisuke Osakabe; Masataka Shiraki; Masao Fukunaga

  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Jul. 2014

  
• Comparison of Statistical Analysis Plans in Randomize-All Phase III Trials with a Predictive Biomarker

  Shigeyuki Matsui; Yuki Choai; Takahiro Nonaka

  CLINICAL CANCER RESEARCH, Jun. 2014

  
• Response to letter to the editor by Dr Wages et al.

  Akihiro Hirakawa; Shigeyuki Matsui

  STATISTICS IN MEDICINE, May 2014

  
• Nested case control study of proteomic biomarkers for interstitial lung disease in Japanese patients with non-small-cell lung cancer treated with erlotinib: A Multicenter phase IV study (JO21661)

  Shinji Atagi; Nobuyuki Katakami; Hiroshige Yoshioka; Masahiro Fukuoka; Shoji Kudoh; Atsushi Ogiwara; Masato Imai; Masamichi Ueda; Shigeyuki Matsui

  Clinical Lung Cancer, Jul. 2013

  
• Empirical Bayes ranking and selection methods via semiparametric hierarchical mixture models in microarray studies

  Hisashi Noma; Shigeyuki Matsui

  STATISTICS IN MEDICINE, May 2013

  
• PREDICTION OF PROGRESSION-FREE SURVIVAL IN PATIENTS UNDERGOING RADICAL CYSTECTOMY FOR LOCALLY ADVANCED BLADDER CANCER USING A SNP PANEL OF CANCER-ASSOCIATED GENES

  Takamitsu Inoue; Shigeyuki Matsui; Norihiko Tsuchiya; Kazuyuki Numakura; Susumu Akihama; Mitsuru Saito; Shintaro Narita; Shigeru Satoh; Wun-Jae Kim; Tomonori Habuchi

  JOURNAL OF UROLOGY, Apr. 2013

  
• Biomarker search using gene expression databases in a phase III, controlled clinical trial (ACTS-CC) of postoperative adjuvant chemotherapy for stage III colon cancer: Results of cluster analysis

  Hiroyuki Uetake; Toshiaki Ishikawa; Megimi Ishiguro; Kenta Murotani; Shigeyuki Matsui; Kenichi Sugihara

  CANCER RESEARCH, Apr. 2013

  
• Meta-analysis of Oro-cecal Transit Time in Fasting Subjects

  Tohru Kokubo; Shigeyuki Matsui; Makio Ishiguro

  PHARMACEUTICAL RESEARCH, Feb. 2013

  
• A dose finding approach based on shrunken predictive probability for combinations of two agents in phase I trials

  Hirakawa A; Hamada C; Matsui S

  Statistics in Medicine, 2013

  
• Cancer Outlier Analysis Based on Mixture Modeling of Gene Expression Data

  Keita Mori; Tomonori Oura; Hisashi Noma; Shigeyuki Matsui

  COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2013

  
• An empirical bayes optimal discovery procedure based on semiparametric hierarchical mixture models

  Hisashi Noma; Shigeyuki Matsui

  Computational and Mathematical Methods in Medicine, 2013

  
• Genomic biomarkers for personalized medicine: Development and Validation in Clinical Studies

  Shigeyuki Matsui

  Computational and Mathematical Methods in Medicine, 2013

  
• Distinct cancer-specific survival in metastatic prostate cancer patients classified by a panel of single nucleotide polymorphisms of cancer-associated genes.

  Tsuchiya N; Matsui S; Narita S; Kamba T; Mitsuzuka K; Hatakeyama S; Horikawa Y; Inoue T; Saito S; Ohyama C; Arai Y; Ogawa O; Habuchi T

  Genes Cancer, Jan. 2013

  
• Developing and Validating Continuous Genomic Signatures in Randomized Clinical Trials for Predictive Medicine

  Shigeyuki Matsui; Richard Simon; Pingping Qu; John D. Shaughnessy; Bart Barlogie; John Crowley

  CLINICAL CANCER RESEARCH, Nov. 2012

  
• Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer

  Megumi Ishiguro; Hidetaka Mochizuki; Naohiro Tomita; Yasuhiro Shimada; Keiichi Takahashi; Kenjiro Kotake; Masahiko Watanabe; Yukihide Kanemitsu; Hideki Ueno; Toshiaki Ishikawa; Hiroyuki Uetake; Shigeyuki Matsui; Satoshi Teramukai; Kenichi Sugihara

  BMC CANCER, Jul. 2012

  
• Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm

  Hiromitsu Negoro; Akihiro Kanematsu; Masao Doi; Sylvia O. Suadicani; Masahiro Matsuo; Masaaki Imamura; Takeshi Okinami; Nobuyuki Nishikawa; Tomonori Oura; Shigeyuki Matsui; Kazuyuki Seo; Motomi Tainaka; Shoichi Urabe; Emi Kiyokage; Takeshi Todo; Hitoshi Okamura; Yasuhiko Tabata; Osamu Ogawa

  NATURE COMMUNICATIONS, May 2012

  
• Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term non-steroidal anti-inflammatory drug (NSAID) therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial

  Kentaro Sugano; Teiji Kontani; Shinichi Katsuo; Yoshinori Takei; Nobuhiro Sakaki; Kiyoshi Ashida; Yuji Mizokami; Masahiro Asaka; Shigeyuki Matsui; Tatsuya Kanto; Satoshi Soen; Tsutomu Takeuchi; Hideyuki Hiraishi; Naoki Hiramatsu

  JOURNAL OF GASTROENTEROLOGY, May 2012

  
• Endoscopic evaluation of non-steroidal anti-inflammatory drug (NSAID)-induced gastric and duodenal ulcers during prophylaxis with lansoprazole

  Sakaki N; Ashida K; Mizokami Y; Asaka M; Matsui S; Kanto T; Hiraishi H; Hiramatsu N; Sugano K

  Journal of Gastroenterology and Hepatology Research, 2012

  
• The optimal discovery procedure in multiple significance testing: an empirical Bayes approach

  Hisashi Noma; Shigeyuki Matsui

  STATISTICS IN MEDICINE, Jan. 2012

  
• Estimating Effect Sizes of Differentially Expressed Genes for Power and Sample-Size Assessments in Microarray Experiments

  Shigeyuki Matsui; Hisashi Noma

  BIOMETRICS, Dec. 2011

  
• 癌関連遺伝子SNPパネルを用いた転移性前立腺癌の予後予測(Prediction of survival in metastatic prostate cancer patients by SNP panel of cancer-associated genes)

  土谷 順彦; 松井 茂之; 成田 伸太郎; 神波 大己; 三塚 浩二; 畠山 真吾; 堀川 洋平; 井上 高光; 斎藤 誠一; 大山 力; 荒井 陽一; 小川 修; 羽渕 友則

  日本癌学会総会記事, Sep. 2011

  
• Population pharmacokinetics of pregabalin in healthy subjects and patients with post-herpetic neuralgia or diabetic peripheral neuropathy

  Satoshi Shoji; Misaki Suzuki; Yoshiro Tomono; Howard N. Bockbrader; Shigeyuki Matsui

  BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Jul. 2011

  
• Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial

  Kentaro Sugano; Yasushi Matsumoto; Tsukasa Itabashi; Sumihisa Abe; Nobuhiro Sakaki; Kiyoshi Ashida; Yuji Mizokami; Tsutomu Chiba; Shigeyuki Matsui; Tatsuya Kanto; Kazuyuki Shimada; Shinichiro Uchiyama; Naomi Uemura; Naoki Hiramatsu

  JOURNAL OF GASTROENTEROLOGY, Jun. 2011

  
• PREDICTION OF SURVIVAL IN METASTATIC PROSTATE CANCER PATIENTS BY SNP ARRAY ANALYSIS OF CANCER-ASSOCIATED GENES

  Norihiko Tsuchiya; Shigeyuki Matsui; Shintaro Narita; Takamitsu Inoue; Kazuyuki Numakura; Yohei Horikawa; Shingo Hatakeyama; Chikara Ohyama; Youichi Arai; Seiichi Saito; Osamu Ogawa; Tomonori Habuchi

  JOURNAL OF UROLOGY, Apr. 2011

  
• Estimation and selection in high-dimensional genomic studies for developing molecular diagnostics

  Shigeyuki Matsui; Hisashi Noma

  BIOSTATISTICS, Apr. 2011

  
• Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: An open-label study

  Koji Yoshimura; Toshiyuki Kamoto; Osamu Ogawa; Shigeyuki Matsui; Norihiko Tsuchiya; Harue Tada; Keiko Murata; Kenichi Yoshimura; Tomonori Habuchi; Masanori Fukushima

  INTERNATIONAL JOURNAL OF UROLOGY, Jun. 2010

  
• Bayesian ranking and selection methods using hierarchical mixture models in microarray studies

  Hisashi Noma; Shigeyuki Matsui; Takashi Omori; Tosiya Sato

  BIOSTATISTICS, Apr. 2010

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• Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling

  N. Matsumura; M. Mandai; T. Okamoto; K. Yamaguchi; T. Oura; T. Baba; S. Mori; S. Murphy; I. Konishi

  GYNECOLOGIC ONCOLOGY, Mar. 2010

  
• Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes

  K. Yamaguchi; M. Mandai; T. Oura; N. Matsumura; J. Hamanishi; T. Baba; S. Matsui; S. K. Murphy; I. Konishi

  ONCOGENE, Mar. 2010

  
• Optimality of gene ranking based on univariate P-values for detecting differentially expressed genes

  Noma H; Matsui S

  Japanese Journal of Biometrics, 2010

  
• Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts

  K. Yamaguchi; M. Mandai; N. Matsumura; T. Baba; T. Oura; S. Matsui; S. K. Murphy; A. Berchuck; S. Fujii; I. Konishi

  GYNECOLOGIC ONCOLOGY, Feb. 2009

  
• Sample sizes for a robust ranking and selection of genes in microarray experiments.

  Matsui S; Oura T

  Statistics in Medicine, 2009

  
• Sample size calculations for controlling the distribution of false discovery proportion in microarray experiments.

  Oura T; Matsui S; Kawakami K

  Biostatistics, 2009

  
• Long-Term Probucol Treatment Prevents Secondary Cardiovascular Events: a Cohort Study of Patients with Heterozygous Familial Hypercholesterolemia in Japan

  Shizuya Yamashita; Hideaki Bujo; Hidenori Arai; Mariko Harada-Shiba; Shigeyuki Matsui; Masanori Fukushima; Yasushi Saito; Toru Kita; Yuji Matsuzawa

  JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Dec. 2008

  
• Overview of the clinical application of regenerative medicine products in Japan

  Mina Tsubouchi; Shigeyuki Matsui; Yoshiro Banno; Kiyoshi Kurokawa; Koji Kawakami

  HEALTH POLICY, Oct. 2008

  
• Critical issues for effective collaboration between academia and industry in the field of regenerative medicine in Japan

  Mina Tsubouchi; Ryuichi Moishita; Yasuhiko Tabata; Sbigeyuki Matsui; Koji Kawakami

  REGENERATIVE MEDICINE, Jul. 2008

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• Efficacy, toxicity and cost analysis for non-platinum triplet (gemcitabine and vinorelbine, followed by docetaxel) vs. platinum-based chemotherapy in IIIB/IV non-small-cell lung cancer: single-institution experience

  H. Tada; S. Matsui; M. Kawahara; S. Hosoe; C. Hamada; M. Fukushima

  EUROPEAN JOURNAL OF CANCER CARE, Mar. 2008

  
• Sample size calculations based on ranking and selection in microarray experiments

  Shigeyuki Matsui; Shu Zeng; Takeharu Yamanaka; John Shaughnessy

  BIOMETRICS, Mar. 2008

  
• Clustering of significant genes in prognostic studies with microarrays: Application to a clinical study for multiple myeloma

  Shigeyuki Matsui; Takeharu Yamanaka; Bart Barlogie; John D. Shaughnessy; John Crowley

  STATISTICS IN MEDICINE, Mar. 2008

  
• P21-activated kinase 1: A new molecular marker for intravesical recurrence after transurethral resection of bladder cancer

  Masaaki Ito; Hiroyuki Nishiyama; Hiroaki Kawanishi; Shigeyuki Matsui; Parry Guilford; Anthony Reeve; Osamu Ogawa

  JOURNAL OF UROLOGY, Sep. 2007

  
• Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models

  Shigeyuki Matsui; Masaaki Ito; Hiroyuki Nishiyama; Hajime Uno; Hirokazu Kotani; Jun Watanabe; Parry Guilford; Anthony Reeve; Masanori Fukushima; Osamu Ogawa

  BIOINFORMATICS, Mar. 2007

  
• Lessons from gefitinib-induced interstitial lung disease in Japan: Problems in approval, pharmacovigilance, and regulatory decision-making procedures.

  Tsutomu Nishimura; Harue Tada; Masatsugu Nakagawa; Satoshi Teramukai; Shigeyuki Matsui; Masanori Fukushima

  Pharmacy practice, Oct. 2006

  
• 癌臨床試験を支援する機構のあり方 臨床研究情報センター(TRI)の役割

  松山 琴音; 永井 洋士; 稲岡 正子; 手良向 聡; 松井 茂之; 福島 雅典; 村上 雅義

  日本癌治療学会誌, Sep. 2006

  
• Predicting survival outcomes using subsets of significant genes in prognostic marker studies with microarrays

  Shigeyuki Matsui

  BMC BIOINFORMATICS, Mar. 2006

  
• Reducing false positive findings in statistical analysis of pharmacogenomic biomarker studies using high-throughput technologies

  Matsui S

  Current Drug Safety2006, 2006

  
• Erythropoietin as a retinal angiogenic factor

  P Manzoni; A Maestri; G Gomirato

  NEW ENGLAND JOURNAL OF MEDICINE, Nov. 2005

  
• Stratified analysis in randomized trials with noncompliance

  S Matsui

  BIOMETRICS, Sep. 2005

  
• Sample size calculations for comparative clinical trials with over-dispersed Poisson process data

  S Matsui

  STATISTICS IN MEDICINE, May 2005

  
• Prognostic factor analysis for plaque psoriasis

  R Sakai; S Matsui; M Fukushima; H Yasuda; H Miyauchi; Y Miyachi

  DERMATOLOGY, 2005

  
• Creutzfeldt-Jakob disease and cadaveric dura mater grafts in Japan: An updated analysis of incubation time

  S Matsui; T Sadaike; C Hamada; M Fukushima

  NEUROEPIDEMIOLOGY, 2005

  
• 何がエンドポイントか エンドポイントの臨床的・統計的論点

  小田 英世; 山中 竹春; 大門 貴志; 手良向 聡; 松井 茂之; 福島 雅典

  薬剤疫学, Nov. 2004

  
• 日本の多施設共同研究の現況と今後 臨床試験における統計家の役割-プロトコル作成から報告まで

  手良向 聡; 小田 英世; 大門 貴志; 福永 至宏; 松井 茂之

  小児がん, Nov. 2004

  
• 全国規模の肺癌外科手術例のアウトカム評価 94年と98年の病理病期別5年生存率について

  横山 奈緒美; 小野寺 理恵; 多田 春江; 中川 正嗣; 松井 茂之; 手良向 聡; 福島 雅典; 肺癌外科アウトカム評価グループ

  肺癌, Oct. 2004

  
• 【再生医療による心臓病治療の最前線 基礎と臨床】再生医療における臨床試験のあり方

  福島 雅典; 手良向 聡; 小島 伸介; 小野寺 理恵; 松井 茂之; 小田 英世

  Cardiovascular Med-Surg, Aug. 2004

  
• 日本の多施設共同研究の現況と今後 臨床試験における統計家の役割 プロトコル作成から報告まで

  手良向 聡; 小田 英世; 大門 貴志; 福永 至宏; 松井 茂之

  日本小児血液学会雑誌, Aug. 2004

  
• Analysis of times to repeated events in two-arm randomized trials with noncompliance and early withdrawal

  Matsui S

  Biometrics, 2004, Peer-reviewed

  
• Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation

  M Kanatsu-Shinohara; S Toyokuni; T Morimoto; S Matsui; T Honjo; T Shinohara

  BIOLOGY OF REPRODUCTION, May 2003

  
• 中間解析におけるベイズ流アプローチ：最近の理論的展開

  宇野一; 松井茂之; 小山暢之

  計量生物学, 2000

  
• 中間解析における頻度論的アプローチ：最近の理論的展開

  松井茂之; 宇野一; 小山暢之

  計量生物学, 2000

  
• Design of clinical trials for recurrent events with periodic monitoring

  S Matsui; H Miyagishi

  STATISTICS IN MEDICINE, Nov. 1999

  
• Analysis of recurrent events: Application to a clinical trial of colony stimulating factor with the endpoint of febrile neutropenia

  S Matsui; Y Ohashi

  STATISTICS IN MEDICINE, Sep. 1999

  

Presentations

• AI医療技術の検証に向けて：現状と課題

  松井茂之

  IBISML, 18 Jan. 2021, 電子情報通信学会, Invited

  
• 医療健康データサイエンティスト：次代の担い手の育成について

  松井茂之

  統計数理研究所医療健康データ科学研究センターシンポジウム, 05 Nov. 2020, 統計数理研究所, Invited

  
• 脳画像を用いた疾患関連解析における神経学的，機能的領域を考慮した多重検定

  江本 遼; 松井茂之

  2020年度 統計関連学会連合大会, 12 Sep. 2020, 統計関連学会連合

  
• 重み付き尤度関数を用いた治療効果のバイアス補正

  豊泉樹一郎; 松井茂之

  2020年度 統計関連学会連合大会, 12 Sep. 2020, 統計関連学会連合

  
• Incorporating follow-up lengths in sample size re-estimation to compare over-dispersed count data

  Masataka Igeta; Shigeyuki Matsui

  ISCB 2020, 25 Aug. 2020, International Society of Clinical Biostatistics

  
• Multiple Testing and Estimation of Disease Associations Based on Semi-Parametric Hierarchical Mixture Models, Possibly Incorporating Brain Areas

  Ryo Emoto; Takahiro Otani; Shigeyuki Matsui

  Eastern North American Region International Biometric Society, 2019 Meeting, 24 Mar. 2019

  
• Blinded Sample Size Re-estimation in Comparative Clinical Trials with Over-Dispersed Count Data: Incorporation of Misspecification of the Variance Function.

  Masataka Igeta; Shigeyuki Matsui

  Eastern North American Region International Biometric Society, 2019 Meeting, 24 Mar. 2019

  
• 単変量Cox回帰にもとづく遺伝子選択と複合共変量による生存期間の予測

  江村剛志; 松井 茂之; Hsuan-Yu Chen

  2018年度統計関連学会連合大会, 10 Sep. 2018

  
• 脳画像を用いた疾患関連解析における効果サイズ推定

  江本 遼; 川口 淳; 松井茂之

  2018年度統計関連学会連合大会, 10 Sep. 2018

  
• 生物・医学分野の新たな展開：データを中心とした拡がり/繋がり

  松井茂之

  2018年度統計関連学会連合大会日本計量生物学会シンポジウム, 10 Sep. 2018, 日本計量生物学会, Invited

  
• Bias-Corrected Estimation of Treatment Effects in Biomarker-Based Adaptive Subgroup Analysis: New Approach Based on Randomized Tests with Smooth Rejection Function

  Kiichiro Toyoizumi; Shigeyuki Matsui

  Joint Statistical Meeting 2019, 28 Jul. 2018

  
• Hierarchical Mixture Modeling for Multiple Testing and Effect Size Estimation in Voxel-Level Inference of Neuroimaging Data.

  Ryo Emoto; Atsushi Kawaguchi; Hisako Yoshida; Shigeyuki Matsui

  Joint Statistical Meeting 2019, 28 Jul. 2018

  
• A Transfer Learning Method for Multi-Center Prognostic Prediction Analysis.

  Kota Matsui; Kenta Kanamori; Wataru Kumagai; Mitsuaki Nishikimi; Shigeyuki Matsui

  3rd International Workshop on Biomedical Informatics with Optimization and Machine Learning in conjunction with 27th International Joint Conference on Artificial Intelligence, 13 Jul. 2018

  
• Two-Stage Analysis for Selecting Fixed Numbers of Features in Omics Association Studies

  Takanori Kawabata; Ryo Emoto; Jo Nishino; Kunihiko Takahashi; Shigeyuki Matsui

  XXIX International Biometric Conference, 12 Jul. 2018

  
• Phase III Clinical Trial Design for Targeted Therapies with Uncertain Biomarker Evidence: Controversies and Solutions (Keynote).

  Matsui S

  OHSU Cancer Biostatistics Workshop, 24 May 2018, Invited

  
• Omics 研究における検証的解析と探索的解析

  佐藤 俊哉; 三中 信宏; 松井茂之; 寒水 孝司

  2017 年度統計関連学会連合大会日本計量生物学会シンポジウム, 04 Sep. 2017, Invited

  
• セミパラメトリック階層混合モデルによる複雑疾患GWASの解析

  西野 穣; 高地 雄太; 重水 大智; 加藤 護; 猪狩 勝則; 越智 秀典; 野間 久史; 松井 孝太; 大谷隆浩; 森園 隆; 松井茂之

  第27回 日本疫学会学術総会, 25 Jan. 2017

  
• セミパラメトリック階層混合モデルによる複雑疾患の遺伝的構造の推定と集団遺伝学的考察

  西野 穣; 松井茂之

  統計数理研究所公募型共同研究重点テーマ2：次世代への健康科学共通公開研究集会, 25 Aug. 2016

  
• Stage III結腸癌におけるDNAコピー数変化と無再発生存期間の関連～ACTS-CC試験のバイオマーカー探索

  石川敏昭; 植竹宏之; 石黒めぐみ; 室谷健太; 中谷英仁; 小武内尚; 松井茂之; 杉原健

  第71回日本消化器外科学会総会, 14 Jul. 2016

  
• A comparison of multiple testing methods for effective strategies in genome-wide association studies

  Otani T; Noma H; Nishino J; Matsui K; Matsui S

  XXVIIIth International Biometric Conference, 10 Jul. 2016

  
• Cancer Outlier Analysis Based on a Nested Two-Way Clustering

  Oura T; Matsui K; Matsui S

  XXVIIIth International Biometric Conference, 10 Jul. 2016

  
• ゲノムワイド関連解析データを用いた複雑疾患の階層混合モデル解析

  西野穣; 高地雄太; 野間久史; 重水大智; 森園隆; 角田達彦; 松井茂之

  2015年度統計関連学会連合大会, 06 Sep. 2015

  
• 予測マーカーと治療の交互作用検定を用いるランダム化臨床試験における治療効果のバイアス補正

  豊泉樹一郎; 松井茂之

  2015年度統計関連学会連合大会, 06 Sep. 2015

  
• Biomarker-based all-comers phase III trials: design issues and solutions

  Matsui S

  The first Pacific Rim Cancer Biostatistics Conference, 14 Aug. 2015

  
• Bias-corrected estimation of treatment effects in biomarker-based randomized clinical trials

  Toyoizumi K; Matsui S

  Joint Statistical Meetings 2015, 11 Aug. 2015

  
• MSI, 18q LOH, and clinicopathological features in stage II sporadic colon cancers: Biomarker study in a Phase III Study of Postoperative Adjuvant Chemotherapy for Stage II Colon Cancer (SACURA trial)

  Ishikawa T; Uetake H; Ishiguro M; Murotani K; Matsui S; Ueno H; Sugihara K; Tomita N; SACURA study group

  第70回日本消化器外科学会総会, 15 Jul. 2015

  
• ACTS-CC study group. CT211 biomarker search using gene expression databases in a phase III, controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC): correlation between clinicopathological factors and gene expression level

  Uetake H; Ishikawa T; Ishiguro M; Matsui S; Sugihara K; ACTS-CC study group

  American Association for Cancer Research Annual Meeting 2015, 22 Apr. 2015

  
• MSI, 18qLOH, and clinicopathologicalfeatures in stage II sporadic colon cancers: Biomarker study in a phase III study of postoperative adjuvantchemotherapyfor stage II colon cancer (SACURA trial)

  Ishikawa T; Uetake H; Ishiguro M; Murotani K; Matsui S; Ueno H; Sugihara K; Tomita N; SACURA study group

  American Association for Cancer Research Annual Meeting 2015, 22 Apr. 2015

  
• ACTS-CC study group. CT211 biomarker search using gene expression databases in a phase III, controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (ACTS-CC): correlation between clinicopathological factors and gene exp

  Uetake H; Ishikawa T; Ishiguro M; Matsui S; Sugihara K; ACTS-CC study group

  American Association for Cancer Research Annual Meeting 2015, 22 Apr. 2015

  
• 計量生物学の更なる可能性を求めて

  松井茂之

  2014 年度日本計量生物学会賞受賞者講演, 12 Mar. 2015

  
• Statistical analysis plans in phase III all-comers clinical trials with a predictive biomarker

  Matsui S

  The XXVII International Biometric Conference, 06 Jul. 2014

  

Books and Other Publications

• 臨床試験の事典

  丹後, 俊郎; 松井, 茂之

  朝倉書店, Jan. 2023

  Find Kyoto University's collection of books :

  
• Biomarker-based phase II and III clinical trials in oncology.

  Matsui S; Igeta M; Toyoizumi K, Joint work

  CRC Press, 2019

  Find Kyoto University's collection of books :

  
• Survival Analysis with Correlated Endpoints: Joint Frailty-Copula Models

  Emura T; Chen YH; Matsui S; Rondeau V, Joint work

  Springer, 2019

  
• Dose-Finding Designs for Early-Phase Cancer Clinical Trials: A Brief Guidebook to Theory and Practice

  Daimon T; Hirakawa A; Matsui S, Joint work

  Springer, 2019

  
• Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combination and Molecularly Targeted Agents.

  Hirakawa A; Sato H; Daimon T; Matsui S, Joint work

  Springer, 2018, Not refereed

  Find Kyoto University's collection of books :

  
• 新版医学統計学ハンドブック

  丹後俊郎; 松井茂之, Joint work

  朝倉書店, 2018, Not refereed

  Find Kyoto University's collection of books :

  
• Frontiers of Biostatistical Methods and Applications in Clinical Oncology.

  Matsui S; Crowley J, Joint work

  Springer, 17 Oct. 2017, Not refereed

  
• Univariate analysis for gene screening: beyond the multiple testing

  Noma H; Matsui S, Joint work

  CRC, 19 Mar. 2015, Not refereed

  
• Statistical issues in clinical development and validation of genomic signatures

  Matsui S, Single work

  CRC, 19 Mar. 2015, Not refereed

  
• Phase III all-comers clinical trials with a predictive biomarker

  Matsui S; Choai Y; Nonaka T, Joint work

  CRC, 19 Mar. 2015, Not refereed

  
• Phase I dose-finding designs and their applicability to targeted therapies

  Daimon T; Hirakawa A; Matsui S, Joint work

  CRC, 19 Mar. 2015, Not refereed

  
• Clinical trials for predictive medicine: new paradigms and challenges. In Design and Analysis of Clinical Trials for Predictive Medicine

  Simon R; Matsui S; Buyse M, Joint work

  CRC, 19 Mar. 2015, Not refereed

  
• Design and Analysis of Clinical Trials for Predictive Medicine

  Matsui S; Buyse M; Simon R, Joint work

  CRC, 19 Mar. 2015, Not refereed

  
• Developments in Statistical Evaluation of Clinical Trials

  Hirakawa A; Matsui S, Joint work

  Springer, 2014, Not refereed

  
• Developments in Statistical Evaluation of Clinical Trials

  Matsui S; Nonaka T; Choai Y, Joint work

  Springer, 2014, Not refereed

  
• Handbook of Statistics in Clinical Oncology, 3rd edn. (eds JJ. Crowley and A Hoering)

  Matsui S; Noma H, Single work

  CRC Press, 2012, Not refereed

  
• Handbook of Statistics in Clinical Oncology, 2nd edn. (eds J.J. Crowley and D.P. Ankerst)

  Matsui S, Single work

  CRC Press, 2006, Not refereed

  
• 臨床試験ハンドブック

  松井茂之, Single work

  朝倉書店, 2006, Not refereed

  

Works

• がん第 I 相試験における 2 剤併用療法の用量探索法：最近の展開

  From 2014

  
• 「臨床試験結果の公開は倫理的、科学的に重要」

  From 2014

  

External funds: Kakenhi

• Statistical evaluation of rare diseases based on individual patient-level data analysis

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 60:Information science, computer engineering, and related fields

  Kyoto University

  松井 茂之

  From 01 Apr. 2026, To 31 Mar. 2030, Granted

  統計科学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26H02491/
• 統計的仮説検定への依存度を減らした仮説検証のための実験計画

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 60:Information science, computer engineering, and related fields

  Kyoto University

  松井 茂之

  From 27 Jun. 2025, To 31 Mar. 2027, Granted

  統計科学;実験的研究;統計的仮説検定

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K22798/
• Use of deep learning and development of statistical prediction result evaluation methods for the acceleration of personalized medicine

  Grant-in-Aid for Scientific Research (C)

  Basic Section 60030:Statistical science-related

  Teikyo University

  松浦 正明

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  統計学;予測問題;個別化医療;深層学習;バイオインフォマティクス;遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K11014/
• Research on statistical and machine learning methods to support adaptive clinical studies in personalized medicine

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 60:Information science, computer engineering, and related fields

  Nagoya University

  Shigeyuki Matsui

  From 05 Apr. 2021, To 31 Mar. 2025, Project Closed

  統計科学;臨床研究;因果推論;予測解析;小標本;個別化医療;機械学習;選択的推論

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04874/
• Development of statistical evaluation method for artificial intelligence and deep learning for personalized medicine

  Grant-in-Aid for Scientific Research (B)

  Basic Section 12040:Applied mathematics and statistics-related

  Teikyo University

  Masaaki Matsuura

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  統計;個別化医療;人口知能;深層学習;データ解析;データサイエンス;疫学;統計学;人工知能

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H01806/
• A new framework of discrimination analysis for high-dimensional data based on estimation of data structure

  Grant-in-Aid for Challenging Exploratory Research

  Nagoya University

  Shigeyuki Matsui

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  判別・予測解析;機械学習;疾患の異質性;統計モデリング;統計科学;構造推定;判別解析;階層混合モデル;統計的判別解析;疾患異質性;高次元データ;疾患の遺伝的異質性;数理工学;生物統計学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K12401/
• Comprehensive research on statistical methodologies and their applications for development of personalized medicine

  Grant-in-Aid for Scientific Research (S)

  Nagoya University

  Shigeyuki Matsui

  From 31 May 2016, To 31 Mar. 2021, Project Closed

  統計科学;生物統計学;機械学習;個別化医療;臨床研究;研究デザイン;データ解析;社会医学;薬剤反応性;臨床試験;統計解析;診断法開発;統計数学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06299/
• Development of statistical methods based on omics data for realizing predictive medicine

  Grant-in-Aid for Scientific Research (B)

  Teikyo University

  Masaaki Matsuura

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  統計;オミックスデータ;バイオマーカー;データ解析;不均一性;統計学;オミクスデータ;ビッグデータ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02671/
• Integration of spatial epidemiology and pharmacoepidemiology for the practical use of the adverse drug event report database with related applications

  Grant-in-Aid for Challenging Exploratory Research

  Nagoya University

  Kunihiko Takahashi

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  空間疫学;薬剤疫学;副作用;自発報告;集積性;疾病集積性;クラスタリング;シグナル検出;有害事象;集積性検出

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26540012/
• Statistical methodology for stabilizing of the genome-omics data analysis

  Grant-in-Aid for Scientific Research (B)

  The Institute of Statistical Mathematics

  Shinto Egichi

  From 01 Apr. 2013, To 31 Mar. 2018, Project Closed

  オミクス　データ;遺伝子ランキング;データ異質性;高次元・小標本;準線形モデル;表現型予測;非線形予測;準線形回帰モデル;拡散テンソル画像;一般化平均;遺伝子発現;クラスター;乳がんデータ;ベキエントロピー;ゲノムワイド探索;遺伝子発現データ;群判別問題;ガンマ・K-平均;ロバスト クラスタリング;メタラーニング;Itakura-Saitoダイバージェンス;特徴ベクトル;2群判別問題;線形判別;ブースティング法;符号和統計量;個人化治療;効果予測

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25280008/
• Design and statistical analysis in translational clinical trials

  Grant-in-Aid for Scientific Research (A)

  Nagoya University;The Institute of Statistical Mathematics

  Shigeyuki Matsui

  From 01 Apr. 2012, To 31 Mar. 2016, Project Closed

  臨床試験;統計的デザイン;データ解析;個別化医療;先端医療技術;臨床試験の計画と解析;先端医療技術の開発;診断法開発;ゲノムデータの解析;ゲノムデータ解析;統計解析;バイオマーカー;予測解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24240042/
• Design and analysis of clinical studies for personalized medicine

  Grant-in-Aid for Scientific Research (C)

  The Institute of Statistical Mathematics

  Shigeyuki MATSUI

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  医学統計;ゲノム薬理学;個別化医療;ゲノムワイド研究;分子診断法の開発;マイクロアレー;臨床研究の計画と解析;階層混合モデル;遺伝子スクリーニング;体外診断法の開発;ベイズ流階層混合モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590599/
• The research to establish the recurrence predicting system for hepatocellular carcinoma patients by use of genome-wide microarray database and to identify therapeutic molecular targets

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Seiji SATOH

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  肝細胞癌;β-カテニン;マイクロアレイ;TaqMan PCR;LOH;再発;SIAH1;PEG10;定量的RT-PCR, Hepatocellular carcinoma;β-atenin;cDNA microarray;TaqMan PCR;LOH;Recurrence;SIAH1;PEG10

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390377/
• The relationship of the consciousness and behavior towards sex and reproduction and psychosocial variable -Determinants of decrease of the unintended pregnancy and abortion-

  Grant-in-Aid for Scientific Research (C)

  KURUME UNIVERSITY;Oita University of Nursing and Health Sciences

  Masako MIZOGUCHI

  From 01 Apr. 2000, To 31 Mar. 2003, Project Closed

  望まない妊娠;中絶;心理社会的変数;未婚者(大学生);既婚者;性及び生殖に対する態度, unintended pregnancy;abortion;psychosocial variable;students;married of the reproduction age;attitudes toward sex and reproduction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12672343/
• 再起的事象を対象とした臨床試験における中間解析に関する研究

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Oita University of Nursing and Health Sciences

  松井 茂之

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  再起的事象;臨床試験;中間解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11780172/

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Methods of Data Analysis

  M348, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Biomedical Data Science

  M347, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to clinical research and clinical development

  3233, Fall, Faculty of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Practice of Clinical Biostatistics-2

  H187, Fall, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Practice of Data Analysis

  H183, Fall, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Practicum in Fundamentals of Statistical Inference

  H144, Spring, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Statistical Modeling and Applications

  H138, Fall, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Practice of Clinical Biostatistics

  H186, Spring, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Machine Learning

  H185, Spring, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Biomedical Data Science

  H184, Spring, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Survival Analysis

  H137, Fall, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Statistical Methods in Clinical Trials

  H135, Fall, Graduate School of Medicine, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Methods of Data Analysis

  H176, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Biomedical Data Science

  H174, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Clinical Research Training II

  H147, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Clinical Research Training I

  H140, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Fundamentals of Statistical Inference

  H136, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Health Policy and Academia

  H127, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Multiplicity in clinical trials

  H145, Spring, Graduate School of Medicine, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Statisticians Standard of Conducts

  H134, Spring, Graduate School of Medicine, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Health Data Processing Laboratory

  H022, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Methods of Data Analysis

  H176, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Practice of Biomedical Data Science

  H175, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Biomedical Data Science

  H174, Spring, Graduate School of Medicine, 2

Participation in PhD Defense

• Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults

  MORI YUICHIRO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2026
• Development and Validation of a Claims-Based Algorithm for Identifying Incident Colorectal Cancer and Determining Progression Phases

  AGATSUMA NOBUKAZU, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2026
• Enhancement of the left frontoparietal network through real－time functional magnetic resonance imaging functional connectivity－informed neurofeedback and its impact on working memory in schizophrenia: A pilot study

  KOBAYASHI YUKO, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2026
• Development of interpretable machine learning models to predict in‐hospital prognosis of acute heart failure patients

  TANAKA MUNEKAZU, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2026
• Joint Analysis of Two Time-to-Event Outcomes Using a Product Partition Model Accounting for Semi-competing Risks

  LEI KANG, Graduate School of Medicine, Chief Examiner

  25 Nov. 2025
• Sex-specific clinical course of young patients with Brugada syndrome

  IMAMURA TOMOHIKO, Graduate School of Medicine, Sub-chief Examiner

  25 Nov. 2025

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2026

  臨床研究審査委員会 委員
• From 01 Apr. 2024, To 31 Mar. 2026

  特定認定再生医療等委員会 委員

Faculty management (title, position)

• From 01 Apr. 2026, To 31 Mar. 2028

  学術情報システム・情報セキュリティ委員会_委員
• From 01 Apr. 2025, To 31 Mar. 2027

  医療DX教育研究センター運営委員会_委員