Basic Information

Professional Memberships

• 日本がん免疫学会
• 日本内科学会
• 日本免疫学会
• 日本血液学会

Academic Degree

• 博士（医学）(京都大学)

ID,URL

• ORCID ID

  0000-0002-3519-4947

• J-Global ID

  202001008340628621

researchmap URL

• https://researchmap.jp/resmapsnagano

Research

Research Areas

• Life sciences, Immunology
• Life sciences, Hematology and oncology

Papers

• ES/iPS細胞を材料とした即納型汎用性T細胞製剤の開発 がんおよびウイルス感染症への応用

  河本 宏; 川瀬 孝和; 永野 誠治

  臨床血液, Sep. 2024

  
• [Development of off-the-shelf universal T cell therapies from ES/iPS cells: applications in cancer and viral infection].

  Hiroshi Kawamoto; Takakazu Kawase; Seiji Nagano

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2024

  
• Development of Immune Cell Therapy Using T Cells Generated from Pluripotent Stem Cells.

  Hiroshi Kawamoto; Kyoko Masuda; Seiji Nagano

  Advances in experimental medicine and biology, 2024

  
• カニクイザルの腫瘍浸潤T細胞から腫瘍殺傷能を有するTCR遺伝子を単離する

  近藤 健太; 寺田 晃士; 石垣 宏仁; 里岡 大樹; 永野 誠治; 増田 喬子; 平田 多佳子; 小笠原 一誠; 伊藤 靖; 河本 宏; 縣 保年

  日本がん免疫学会総会プログラム・抄録集, Sep. 2020

  
• 分泌型PD-L1スプライシングバリアントを介した免疫チェックポイント治療薬耐性機構の発見

  キョウ 博; 清谷 一馬; 坂田 征士; 永野 誠治; 粂原 俊; 馬場 郷子; 柳谷 典子; 西尾 誠人; 竹内 賢吾; 河本 宏; 藤田 直也; 片山 量平

  日本がん免疫学会総会プログラム・抄録集, Jul. 2019

  
• 脳室炎と類似する画像所見を呈した中枢神経原発悪性リンパ腫

  山本 司郎; 永野 誠治; 芝田 純也; 國枝 武治; 今井 幸弘; 幸原 伸夫

  臨床神経学, Oct. 2013, Peer-reviewed

  
• iPS細胞技術を用いたWT1抗原特異的再生キラーT細胞の腎細胞癌に対する抗腫瘍効果

  嘉島 相輝; 前田 卓也; 永野 誠治; 増田 喬子; 井上 高光; 安川 正貴; 小林 恭; 山崎 俊成; 小川 修; 羽渕 友則; 河本 宏

  日本がん免疫学会総会プログラム・抄録集, Jul. 2019

  
• 治療抵抗性血管免疫芽球性T細胞性リンパ腫に対するCyclosporin Aの有用性

  森 美奈子; 井上 大地; 有馬 浩史; 瀧内 曜子; 永野 誠治; 木村 隆治; 下地 園子; 永井 雄也; 田端 淑恵; 柳田 宗之; 松下 章子; 永井 謙一; 今井 幸弘; 高橋 隆幸

  臨床血液, May 2010

  
• Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.

  Koji Terada; Kenta Kondo; Hirohito Ishigaki; Ayaka Nagashima; Hiroki Satooka; Seiji Nagano; Kyoko Masuda; Teruhisa Kawamura; Takako Hirata; Kazumasa Ogasawara; Yasushi Itoh; Hiroshi Kawamoto; Yasutoshi Agata

  Molecular therapy oncolytics, 17 Mar. 2022

  
• Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology

  Hiroshi Kawamoto; Kyoko Masuda; Seiji Nagano

  International Immunology, 18 Oct. 2021

  
• Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes.

  Takuya Maeda; Seiji Nagano; Soki Kashima; Koji Terada; Yasutoshi Agata; Hiroshi Ichise; Manami Ohtaka; Mahito Nakanishi; Fumihiro Fujiki; Haruo Sugiyama; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto

  Molecular therapy. Methods & clinical development, 11 Dec. 2020

  
• Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.

  Soki Kashima; Takuya Maeda; Kyoko Masuda; Seiji Nagano; Takamitsu Inoue; Masashi Takeda; Yuka Kono; Takashi Kobayashi; Shigeyoshi Saito; Takahiro Higuchi; Hiroshi Ichise; Yuka Kobayashi; Keiko Iwaisako; Koji Terada; Yasutoshi Agata; Kazuyuki Numakura; Mitsuru Saito; Shintaro Narita; Masaki Yasukawa; Osamu Ogawa; Tomonori Habuchi; Hiroshi Kawamoto

  iScience, 24 Apr. 2020, Peer-reviewed

  Access this paper :

  
• High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells.

  Seiji Nagano; Takuya Maeda; Hiroshi Ichise; Soki Kashima; Manami Ohtaka; Mahito Nakanishi; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto

  Molecular therapy. Methods & clinical development, 13 Mar. 2020, Peer-reviewed

  
• [Mass-Production of Tumor Antigen-Specific Cytotoxic T Lymphocytes Using the iPS Cell Technology-Development of "Off-the-Shelf T Cells"for the Use in Allogeneic Transfusion Settings].

  Hiroshi Kawamoto; Seiji Nagano

  Gan to kagaku ryoho. Cancer & chemotherapy, Nov. 2019, Peer-reviewed

  
• Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.

  Bo Gong; Kazuma Kiyotani; Seiji Sakata; Seiji Nagano; Shun Kumehara; Satoko Baba; Benjamin Besse; Noriko Yanagitani; Luc Friboulet; Makoto Nishio; Kengo Takeuchi; Hiroshi Kawamoto; Naoya Fujita; Ryohei Katayama

  The Journal of experimental medicine, 01 Apr. 2019, Peer-reviewed

  
• Cloning and expansion of antigen-specific T cells using iPS cell technology: development of "off-the-shelf" T cells for the use in allogeneic transfusion settings.

  Hiroshi Kawamoto; Kyoko Masuda; Seiji Nagano; Takuya Maeda

  International journal of hematology, Mar. 2018, Peer-reviewed

  
• NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs.

  Hiroshi Ichise; Seiji Nagano; Takuya Maeda; Masaki Miyazaki; Yuki Miyazaki; Hiroto Kojima; Nobuyo Yawata; Makoto Yawata; Hidenori Tanaka; Hiroh Saji; Kyoko Masuda; Hiroshi Kawamoto

  Stem cell reports, 12 Sep. 2017, Peer-reviewed

  Access this paper :

  
• Regeneration of CD8αβ T Cells from T-cell-Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity.

  Takuya Maeda; Seiji Nagano; Hiroshi Ichise; Keisuke Kataoka; Daisuke Yamada; Seishi Ogawa; Haruhiko Koseki; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto

  Cancer research, 01 Dec. 2016, Peer-reviewed

  
• Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.

  Keisuke Kataoka; Yuichi Shiraishi; Yohei Takeda; Seiji Sakata; Misako Matsumoto; Seiji Nagano; Takuya Maeda; Yasunobu Nagata; Akira Kitanaka; Seiya Mizuno; Hiroko Tanaka; Kenichi Chiba; Satoshi Ito; Yosaku Watatani; Nobuyuki Kakiuchi; Hiromichi Suzuki; Tetsuichi Yoshizato; Kenichi Yoshida; Masashi Sanada; Hidehiro Itonaga; Yoshitaka Imaizumi; Yasushi Totoki; Wataru Munakata; Hiromi Nakamura; Natsuko Hama; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Takuro Kameda; Kyoko Masuda; Nagahiro Minato; Koichi Kashiwase; Koji Izutsu; Akifumi Takaori-Kondo; Yasushi Miyazaki; Satoru Takahashi; Tatsuhiro Shibata; Hiroshi Kawamoto; Yoshiki Akatsuka; Kazuya Shimoda; Kengo Takeuchi; Tsukasa Seya; Satoru Miyano; Seishi Ogawa

  Nature, 16 Jun. 2016, Peer-reviewed

  
• Preeclampsia as a Manifestation of New-Onset Systemic Lupus Erythematosus during Pregnancy: A Case-Based Literature Review.

  Taito Miyamoto; Tatsuji Hoshino; Nobutaka Hayashi; Ruriko Oyama; Asuka Okunomiya; Sachiko Kitamura; Noriko Ohtake; Mami Suga; Kazunao Miyamoto; Aki Takaoka; Takuya Aoki; Yuko Imamura; Seiji Nagano; Masato Kita

  AJP reports, Mar. 2016, Peer-reviewed

  
• IP-10/CXCL10 and MIG/CXCL9 as novel markers for the diagnosis of lymphoma-associated hemophagocytic syndrome.

  Hayato Maruoka; Daichi Inoue; Yoko Takiuchi; Seiji Nagano; Hiroshi Arima; Sumie Tabata; Akiko Matsushita; Takayuki Ishikawa; Tatsuo Oita; Takayuki Takahashi

  Annals of hematology, Mar. 2014, Peer-reviewed

  
• Therapeutic effects of lenalidomide on hemorrhagic intestinal myeloma-associated AL amyloidosis.

  Seiji Nagano; Minako Mori; Aiko Kato; Yuichiro Ono; Kazunari Aoki; Hiroshi Arima; Yoko Takiuchi; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Takayuki Ishikawa; Hiroyuki Imai; Takayuki Takahashi

  Internal medicine (Tokyo, Japan), 2013, Peer-reviewed

  
• [Primary central nervous system lymphoma mimicking ventriculitis].

  Shiro Yamamoto; Seiji Nagano; Sumiya Shibata; Takeharu Kunieda; Yukihiro Imai; Nobuo Kohara

  Rinsho shinkeigaku = Clinical neurology, 2013, Peer-reviewed

  
• [Fatal hepatic failure due to AL amyloidosis in a patient with multiple myeloma].

  Sumie Tabata; Masayuki Kurata; June Takeda; Yuuki Funayama; Nobuhiko Yamauchi; Kazunari Aoki; Aiko Kato; Yuichirou Ono; Hiroshi Arima; Yoko Takiuchi; Seiji Nagano; Akiko Matsushita; Yukihiro Imai; Takayuki Ishikawa; Takayuki Takahashi

  [Rinsho ketsueki] The Japanese journal of clinical hematology, Nov. 2012, Peer-reviewed

  
• Successful treatment of γ-heavy-chain disease with rituximab and fludarabine.

  Daichi Inoue; Akiko Matsushita; Mineyo Kiuchi; Yoko Takiuchi; Seiji Nagano; Hiroshi Arima; Minako Mori; Sumie Tabata; Akiko Yamashiro; Hayato Maruoka; Tatsuo Oita; Yukihiro Imai; Takayuki Takahashi

  Acta haematologica, 2012, Peer-reviewed

  
• Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia.

  Yoko Takiuchi; Hayato Maruoka; Kazunari Aoki; Aiko Kato; Yuichiro Ono; Seiji Nagano; Hiroshi Arima; Daichi Inoue; Minako Mori; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Mari Nishio; Yukihiro Imai; Yukihiro Imai; Kiminari Ito; Haruyuki Fujita; Norimitsu Kadowaki; Takayuki Ishikawa; Takayuki Takahashi

  Journal of clinical and experimental hematopathology : JCEH, 2012, Peer-reviewed

  
• Blastic plasmacytoid dendritic cell neoplasm expressing the CD13 myeloid antigen.

  Daichi Inoue; Kyoko Maruyama; Kazunari Aoki; Seiji Nagano; Hayato Maruoka; Yukihiro Imai; Kiminari Ito; Takayuki Ishikawa; Takayuki Takahashi

  Acta haematologica, 2011, Peer-reviewed

  
• Enteropathy-associated T-cell lymphoma type II complicated by autoimmune hemolytic anemia.

  Aiko Kato; Yoko Takiuchi; Kazunari Aoki; Yuichiro Ono; Hiroshi Arima; Seiji Nagano; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Hayato Maruoka; Masaya Wada; Yukihiro Imai; Takayuki Ishikawa; Takayuki Takahashi

  Journal of clinical and experimental hematopathology : JCEH, 2011, Peer-reviewed

  
• Systemic follicular lymphoma with massive intestinal involvement with leukemic manifestation.

  Yuichiro Ono; Kazunari Aoki; Aiko Kato; Hiroshi Arima; Yohko Takiuchi; Seiji Nagano; Sumie Tabata; Sohshi Yanagita; Akiko Matsushita; Hayato Maruoka; Yukihiro Imai; Takayuki Ishikawa; Takayuki Takahashi

  Journal of clinical and experimental hematopathology : JCEH, 2011, Peer-reviewed

  
• Excellent therapeutic effect of tocilizumab on intestinal amyloid a deposition secondary to active rheumatoid arthritis.

  Daichi Inoue; Hiroshi Arima; Chiharu Kawanami; Yoko Takiuchi; Seiji Nagano; Takaharu Kimura; Sonoko Shimoji; Minako Mori; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Kenichi Nagai; Yukihiro Imai; Takayuki Takahashi

  Clinical rheumatology, Oct. 2010, Peer-reviewed

  
• Histiocytic sarcoma and underlying chronic myelomonocytic leukemia: a proposal for the developmental classification of histiocytic sarcoma.

  Minako Mori; Akiko Matsushita; Yohko Takiuchi; Hiroshi Arima; Seiji Nagano; Sonoko Shimoji; Takaharu Kimura; Daichi Inoue; Sumie Tabata; Sohshi Yanagita; Kenichi Nagai; Yukihiro Imai; Takayuki Takahashi

  International journal of hematology, Jul. 2010, Peer-reviewed

  
• Fulminant sepsis caused by Bacillus cereus in patients with hematologic malignancies: analysis of its prognosis and risk factors.

  Daichi Inoue; Yuya Nagai; Minako Mori; Seiji Nagano; Yoko Takiuchi; Hiroshi Arima; Takaharu Kimura; Sonoko Shimoji; Katsuhiro Togami; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Kenichi Nagai; Yukihiro Imai; Hiroshi Takegawa; Takayuki Takahashi

  Leukemia & lymphoma, May 2010, Peer-reviewed

  
• [Therapeutic efficacy of cyclosporin A for refractory angioimmunoblastic T cell lymphoma].

  Minako Mori; Daichi Inoue; Hiroshi Arima; Yohko Takiuchi; Seiji Nagano; Takaharu Kimura; Sonoko Shimoji; Yuya Nagai; Sumie Tabata; Sohshi Yanagita; Akiko Matsushita; Kenichi Nagai; Yukihiro Imai; Takayuki Takahashi

  [Rinsho ketsueki] The Japanese journal of clinical hematology, May 2010, Peer-reviewed

  
• Successful treatment of extranodal natural killer/T-cell lymphoma, nasal type, complicated by severe hemophagocytic syndrome, with dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide chemotherapy followed by autologous stem cell transplant.

  Daichi Inoue; Yuya Nagai; Yoko Takiuchi; Seiji Nagano; Hiroshi Arima; Takaharu Kimura; Sonoko Shimoji; Minako Mori; Katsuhiro Togami; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Kenichi Nagai; Hayato Maruoka; Yukihiro Imai; Ritsuro Suzuki; Takayuki Takahashi

  Leukemia & lymphoma, Apr. 2010, Peer-reviewed

  
• Successful allogeneic bone marrow transplantation for diamond-blackfan anemia complicated by severe cardiac dysfunction due to transfusion-induced hemochromatosis.

  Sumie Tabata; Minako Mori; Yuya Nagai; Hisako Hashimoto; Hiroshi Arima; Seiji Nagano; Yoko Takiuchi; Daichi Inoue; Takaharu Kimura; Sonoko Shimoji; Soshi Yanagita; Kiminari Ito; Akiko Matsushita; Kenichi Nagai; Takayuki Takahashi

  Internal medicine (Tokyo, Japan), 2010, Peer-reviewed

  

Misc.

• TCR遺伝子導入iPS細胞からCTLを再生するための新規の方法:TCRカセット法の開発

  永野誠治; 寺田晃士; 前田卓也; 嘉島相輝; 縣保年; 増田喬子; 河本宏

  日本がん免疫学会総会プログラム・抄録集, 2020

  
• iPS細胞技術を用いたがん抗原特異的T細胞の再生

  永野誠治; 永野誠治; 前田卓也; 嘉島相輝; 嘉島相輝; 増田喬子; 河本宏

  日本がん免疫学会総会プログラム・抄録集, 2019

  
• REGENERATION OF WT1 SPECIFIC CTLS UTILIZING IPSC TECHNOLOGY

  T. Maeda; S. Nagano; K. Masuda; T. Kitawaki; A. Takaori-Kondo; H. Kawamoto

  HAEMATOLOGICA, Jun. 2016

  
• Cancer immunotherapy using T cells regenerated from iPS cells-Development of universal ”off-the-shelf” T cell medicine

  河本宏; 河本宏; 増田喬子; 永野誠治; 永野誠治

  医学のあゆみ, 2022

  
• Development of universal “off-the-shelf” T cells for cancer immunotherapy.

  河本宏; 増田喬子; 永野誠治; 永野誠治

  月刊腫瘍内科, 2021

  
• iPS技術を用いたNY-ESO-1特異的細胞傷害性T細胞の再生と成人T細胞性白血病および多発性骨髄腫治療への応用

  島津 裕; 前田 卓也; 永野 誠治; 島津 弥生; 菱澤 方勝; 石田 高司; 一瀬 大志; 増田 喬子; 直川 匡晴; 高折 晃史; 河本 宏

  日本リンパ網内系学会会誌, May 2017

  
• iPS技術を用いたNY-ESO-1特異的細胞傷害性T細胞の再生と成人T細胞性白血病および多発性骨髄腫治療への応用

  島津 裕; 前田 卓也; 永野 誠治; 島津 弥生; 菱澤 方勝; 石田 高司; 一瀬 大志; 増田 喬子; 直川 匡晴; 高折 晃史; 河本 宏

  日本リンパ網内系学会会誌, May 2017

  
• 肝アミロイドーシスによる肝不全で死亡した多発性骨髄腫

  田端 淑恵; 倉田 雅之; 竹田 淳恵; 船山 由樹; 山内 寛彦; 青木 一成; 加藤 愛子; 小野 祐一郎; 有馬 浩史; 瀧内 曜子; 永野 誠治; 松下 章子; 今井 幸弘; 石川 隆之; 高橋 隆幸

  臨床血液, Nov. 2012

  
• 高リスクMDSに対するAzacitidineの治療効果

  田端 淑恵; 竹田 淳恵; 船山 由樹; 山内 寛彦; 青木 一成; 加藤 愛子; 小野 祐一郎; 有馬 浩史; 瀧内 曜子; 永野 誠治; 松下 章子; 石川 隆之

  臨床血液, Sep. 2012

  
• Triple Hit lymphomaの1例

  竹田 淳恵; 永野 誠治; 小野 祐一郎; 船山 由樹; 山内 寛彦; 青木 一成; 加藤 愛子; 田端 淑恵; 松下 章子; 石川 隆之; 丸岡 隼人

  日本リンパ網内系学会会誌, May 2012

  
• 6カラーフローサイトメトリーによる造血器腫瘍のイムノフェノタイピング

  丸岡 隼人; 江藤 正明; 那須 浩二; 老田 達雄; 岸本 健治; 宇佐美 郁哉; 青木 一成; 小野 祐一郎; 加藤 愛子; 有馬 浩史; 瀧内 曜子; 永野 誠治; 田端 淑恵; 柳田 宗之; 松下 章子; 高橋 隆幸; 石川 隆之

  神戸市立病院紀要, Mar. 2012

  
• Double Ph cloneが確認されたCMLに対しダサチニブを使用した1例

  永野 誠治; 竹田 淳恵; 船山 由樹; 山内 寛彦; 青木 一成; 小野 祐一郎; 加藤 愛子; 有馬 浩史; 瀧内 曜子; 田端 淑恵; 松下 章子; 石川 隆之

  臨床血液, Jan. 2012

  
• 大顆粒リンパ球性白血病に合併した赤芽球癆によるヘモクロマトーシスに行った鉄キレート療法

  永野 誠治; 青木 一成; 小野 祐一郎; 加藤 愛子; 有馬 浩史; 瀧内 曜子; 田端 淑恵; 柳田 宗之; 松下 章子; 石川 隆之

  臨床血液, Aug. 2011

  
• Identification of secreted PD-L1 variants as a decoy of PD-L1 blockade antibody mediating the therapeutic resistance

  Bo Gong; Kazuma Kiyotani; Seiji Sakata; Ken Takahashi; Seiji Nagano; Shun Kumehara; Satoko Baba; Benjamin Besse; Noriko Yanagitani; Luc Friboulet; Makoto Nishio; Kengo Takeuchi; Hiroshi Kawamoto; Naoya Fujita; Ryohei Katayama

  MOLECULAR CANCER THERAPEUTICS, Dec. 2019

  
• iPS細胞技術を用いたがん抗原特異的CTLの量産 他家移植用再生T細胞製剤の開発

  河本 宏; 永野誠治

  癌と化学療法, 2019

  
• iPS細胞技術のがん免疫療法への応用の可能性

  永野誠治; 河本 宏

  炎症と免疫, 2018

  

External funds: Kakenhi

• Regeneration of T cells specific for cancer antigen using iPSC and genome editing technology

  Grant-in-Aid for Early-Career Scientists

  Basic Section 54010:Hematology and medical oncology-related

  Kyoto University

  Seiji Nagano

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  再生T細胞;がん免疫細胞療法;CTL;TCR遺伝子;iPS細胞;ゲノム編集技術;再生医療;RMCE;再生CTL;がん抗原特異的TCR遺伝子;T細胞療法;免疫学;がん;がん免疫療法;T細胞輸注;iPS細胞からT細胞への再生

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16113/
• 他家iPS細胞から再生させた材料T細胞を土台にしたTCR/CAR-T細胞の作製

  Grant-in-Aid for Scientific Research (C)

  Basic Section 54010:Hematology and medical oncology-related

  Kyoto University

  永野 誠治

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  他家再生T細胞;iPS/ES細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08503/

Administration

Faculty management (title, position)

• From 01 Apr. 2023

  化学物質管理委員会　委員