Basic Information

Faculty

• Faculty of Science

Email Address

• Email Address

  mizuno.misao.3wkyoto-u.ac.jp

Academic Degree

• 15 Mar. 1998

  早稲田大学修士（理学）
• 03 Feb. 2005

  早稲田大学博士（理学）

Academic Resume (Undergraduate School/Majors)

• 早稲田大学, 理工学部化学科, 卒業

Research History

• From Apr. 2023, To Present

  Kyoto University, Graduate School of Science Division of Chemistry, 准教授
• From Aug. 2007, To Mar. 2023

  Osaka University, Graduate School of Science Department of Chemistry, 助教
• From Apr. 2006, To Jul. 2007

  Osaka University, Graduate School of Science Department of Chemistry, 日本学術振興会特別研究員（PD）
• From Apr. 2005, To Mar. 2006

  Kobe University, Molecular Photoscience Research Center, 日本学術振興会特別研究員（PD）
• From Apr. 2002, To Mar. 2005

  RIKEN, 協力研究員
• From Apr. 1999, To Mar. 2002

  Institute for Molecular Science, 技官

ID,URL

• ORCID ID

  0000-0003-2206-1763

• J-Global ID

  202001017646557824

• Researcher number

  10464257

Website(s) (URL(s))

• https://sites.google.com/kyoto-u.ac.jp/kuchem-mizuno/

researchmap URL

• https://researchmap.jp/mizunomisao

Research

Papers

• Unusual Vibrational Coupling of the Schiff Base in the Retinal Chromophore of Sodium Ion-Pumping Rhodopsins

  Taiki Nakamura; Yuka Shinozaki; Akihiro Otomo; Taito Urui; Misao Mizuno; Rei Abe-Yoshizumi; Manami Hashimoto; Keiichi Kojima; Yuki Sudo; Hideki Kandori; Yasuhisa Mizutani

  The Journal of Physical Chemistry B, 01 Aug. 2024

  
• Vibrational energy flow in hemeproteins

  Yasuhisa Mizutani; Naoki Fujii; Mitsuhiro Miyamoto; Misao Mizuno; Haruto Ishikawa

  Optics InfoBase Conference Papers, 2014

  
• Chromophore–Protein Interactions Affecting the Polyene Twist and π–π* Energy Gap of the Retinal Chromophore in Schizorhodopsins

  Taito Urui; Tomomi Shionoya; Misao Mizuno; Keiichi Inoue; Hideki Kandori; Yasuhisa Mizutani

  The Journal of Physical Chemistry B, 04 Mar. 2024

  
• Cis-Trans Reisomerization Preceding Reprotonation of the Retinal Chromophore Is Common to the Schizorhodopsin Family: A Simple and Rational Mechanism for Inward Proton Pumping.

  Taito Urui; Kouhei Hayashi; Misao Mizuno; Keiichi Inoue; Hideki Kandori; Yasuhisa Mizutani

  The journal of physical chemistry. B, 25 Jan. 2024

  
• Unique Vibrational Characteristics and Structures of the Photoexcited Retinal Chromophore in Ion-Pumping Rhodopsins.

  Zixuan Li; Misao Mizuno; Tomo Ejiri; Shigehiko Hayashi; Hideki Kandori; Yasuhisa Mizutani

  The journal of physical chemistry. B, 23 Nov. 2023

  
• Heme Pocket Structure and Its Functional Implications in an Ancestral Globin Protein.

  Yu Iritani; Haruto Ishikawa; Misao Mizuno; Yasuhisa Mizutani

  Biochemistry, 19 Sep. 2023

  
• Chromophore Structure in an Inactive State of a Novel Photosensor Protein Opn5L1: Resonance Raman Evidence for the Formation of a Deprotonated Adduct at the 11th Carbon Atom.

  Misao Mizuno; Keita Sato; Takahiro Yamashita; Kazumi Sakai; Yasushi Imamoto; Yumiko Yamano; Akimori Wada; Hideyo Ohuchi; Yoshinori Shichida; Yasuhisa Mizutani

  The journal of physical chemistry. B, 16 Mar. 2023, Peer-reviewed

  
• Protein dynamics of a light-driven Na⁺ pump rhodopsin probed using a tryptophan residue near the retinal chromophore

  Akihiro Otomo; Misao Mizuno; Keiichi Inoue; Hideki Kandori; Yasuhisa Mizutani

  Biophysics and Physicobiology, 2023, Peer-reviewed

  
• Time-resolved Spectroscopic Mapping of Vibrational Energy Flow in Proteins: Understanding Thermal Diffusion at the Nanoscale

  Yasuhisa Mizutani; Misao Mizuno

  The Journal of Chemical Physics, 18 Oct. 2022, Peer-reviewed, Invited, Corresponding author

  
• Contact-Mediated Retinal–Opsin Coupling Enables Proton Pumping in Gloeobacter Rhodopsin

  Tomomi Shionoya; Misao Mizuno; Hideki Kandori; Yasuhisa Mizutani

  The Journal of Physical Chemistry B, 13 Oct. 2022, Peer-reviewed

  
• Origin of a Double-Band Feature in the Ethylenic C=C Stretching Modes of the Retinal Chromophore in Heliorhodopsins

  Taito Urui; Ishita Das; Misao Mizuno; Mordechai Sheves; Yasuhisa Mizutani

  JOURNAL OF PHYSICAL CHEMISTRY B, Oct. 2022, Peer-reviewed

  
• Cis – Trans Reisomerization Precedes Reprotonation of the Retinal Chromophore in the Photocycle of Schizorhodopsin 4

  Kouhei Hayashi; Misao Mizuno; Hideki Kandori; Yasuhisa Mizutani

  Angewandte Chemie International Edition, 15 Aug. 2022, Peer-reviewed

  
• Dependence of Vibrational Energy Transfer on Distance in a Four-Helix Bundle Protein: Equidistant Increments with the Periodicity of α Helices

  Satoshi Yamashita; Misao Mizuno; Kazuhiro Takemura; Akio Kitao; Yasuhisa Mizutani

  The Journal of Physical Chemistry B, 05 May 2022, Peer-reviewed

  
• High suitability of tryptophan residues as a spectroscopic thermometer for local temperature in proteins under nonequilibrium conditions

  Satoshi Yamashita; Misao Mizuno; Yasuhisa Mizutani

  The Journal of Chemical Physics, 21 Feb. 2022, Peer-reviewed

  
• Strongly Hydrogen-Bonded Schiff Base and Adjoining Polyene Twisting in the Retinal Chromophore of Schizorhodopsins

  Tomomi Shionoya; Manish Singh; Misao Mizuno; Hideki Kandori; Yasuhisa Mizutani

  Biochemistry, 19 Oct. 2021, Peer-reviewed

  
• Resonance Raman Determination of Chromophore Structures of Heliorhodopsin Photointermediates

  Taito Urui; Misao Mizuno; Akihiro Otomo; Hideki Kandori; Yasuhisa Mizutani

  The Journal of Physical Chemistry B, 08 Jul. 2021, Peer-reviewed

  
• Regulatory Switching by Concerted Motions on the Microsecond Time Scale of the Oxygen Sensor Protein FixL

  Takeo Yamawaki; Misao Mizuno; Haruto Ishikawa; Kazuhiro Takemura; Akio Kitao; Yoshitsugu Shiro; Yasuhisa Mizutani

  The Journal of Physical Chemistry B, 01 Jul. 2021, Invited

  
• Nonbonded Atomic Contacts Drive Ultrafast Helix Motions in Myoglobin

  Shinya Tahara; Misao Mizuno; Yasuhisa Mizutani

  The Journal of Physical Chemistry B, 02 Jul. 2020, Peer-reviewed

  
• Role of atomic contacts in vibrational energy transfer in myoglobin

  Misao Mizuno; Yasuhisa Mizutani

  Biophysical Reviews, 23 Mar. 2020, Peer-reviewed

  
• Allosteric Communication with the Retinal Chromophore upon Ion Binding in a Light-Driven Sodium Ion-Pumping Rhodopsin

  Akihiro Otomo; Misao Mizuno; Keiichi Inoue; Hideki Kandori; Yasuhisa Mizutani

  Biochemistry, 04 Feb. 2020, Peer-reviewed

  
• Effect of a bound anion on the structure and dynamics of halorhodopsin from Natronomonas pharaonis

  Misao Mizuno; Yumi Shimoo; Hideki Kandori; Yasuhisa Mizutani

  Struct. Dynam, Oct. 2019, Peer-reviewed

  
• Distortion and a Strong Hydrogen Bond in the Retinal Chromophore Enable Sodium-Ion Transport by the Sodium-Ion Pump KR2

  Nao Nishimura; Misao Mizuno; Hideki Kandori; Yasuhisa Mizutani

  The Journal of Physical Chemistry B, 25 Apr. 2019, Peer-reviewed

  
• Resonance Raman Investigation of the Chromophore Structure of Heliorhodopsins.

  Otomo A; Mizuno M; Singh M; Shihoya W; Inoue K; Nureki O; Béjà O; Kandori H; Mizutani Y

  The journal of physical chemistry letters, Nov. 2018, Peer-reviewed

  
• Tertiary dynamics of human adult hemoglobin fixed in R and T quaternary structures

  Chang, S.; Mizuno, M.; Ishikawa, H.; Mizutani, Y.

  Physical Chemistry Chemical Physics, 2018, Peer-reviewed

  
• Vibrational Energy Transfer from Heme through Atomic Contacts in Proteins

  Yamashita, S.; Mizuno, M.; Tran, D.P.; Dokainish, H.; Kitao, A.; Mizutani, Y.

  Journal of Physical Chemistry B, 2018, Peer-reviewed

  
• High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment

  Shionoya, T.; Mizuno, M.; Tsukamoto, T.; Ikeda, K.; Seki, H.; Kojima, K.; Shibata, M.; Kawamura, I.; Sudo, Y.; Mizutani, Y.

  Journal of Physical Chemistry B, 2018, Peer-reviewed

  
• Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor

  Sato, K.; Yamashita, T.; Ohuchi, H.; Takeuchi, A.; Gotoh, H.; Ono, K.; Mizuno, M.; Mizutani, Y.; Tomonari, S.; Sakai, K.; Imamoto, Y.; Wada, A.; Shichida, Y.

  Nature Communications, 2018, Peer-reviewed

  Access this paper :

  
• Structural Evolution of a Retinal Chromophore in the Photocycle of Halorhodopsin from Natronobacterium pharaonis

  Mizuno, M.; Nakajima, A.; Kandori, H.; Mizutani, Y.

  Journal of Physical Chemistry A, 2018, Peer-reviewed

  
• Production of a Light-Gated Proton Channel by Replacing the Retinal Chromophore with Its Synthetic Vinylene Derivative

  Takayama, R.; Kaneko, A.; Okitsu, T.; Tsunoda, S.P.; Shimono, K.; Mizuno, M.; Kojima, K.; Tsukamoto, T.; Kandori, H.; Mizutani, Y.; Wada, A.; Sudo, Y.

  Journal of Physical Chemistry Letters, 2018, Peer-reviewed

  
• Demonstration of a Light-Driven SO4^2-Transporter and Its Spectroscopic Characteristics

  Niho, A.; Yoshizawa, S.; Tsukamoto, T.; Kurihara, M.; Tahara, S.; Nakajima, Y.; Mizuno, M.; Kuramochi, H.; Tahara, T.; Mizutani, Y.; Sudo, Y.

  Journal of the American Chemical Society, 2017, Peer-reviewed

  
• Importance of Atomic Contacts in Vibrational Energy Flow in Proteins

  Kondoh, M.; Mizuno, M.; Mizutani, Y.

  Journal of Physical Chemistry Letters, 2016, Peer-reviewed

  
• A Study of the Dynamics of the Heme Pocket and C-helix in CooA upon CO Dissociation Using Time-Resolved Visible and UV Resonance Raman Spectroscopy

  Otomo, A.; Ishikawa, H.; Mizuno, M.; Kimura, T.; Kubo, M.; Shiro, Y.; Aono, S.; Mizutani, Y.

  Journal of Physical Chemistry B, 2016, Peer-reviewed

  
• Chromophore Structure of Photochromic Fluorescent Protein Dronpa: Acid-Base Equilibrium of Two Cis Configurations

  Higashino, A.; Mizuno, M.; Mizutani, Y.

  Journal of Physical Chemistry B, 2016, Peer-reviewed

  
• Regulatory Implications of Structural Changes in Tyr201 of the Oxygen Sensor Protein FixL

  Yamawaki, T.; Ishikawa, H.; Mizuno, M.; Nakamura, H.; Shiro, Y.; Mizutani, Y.

  Biochemistry, 2016, Peer-reviewed

  
• Effect of the N-terminal residues on the quaternary dynamics of human adult hemoglobin

  Chang, S.; Mizuno, M.; Ishikawa, H.; Mizutani, Y.

  Chemical Physics, 2016, Peer-reviewed

  
• Vibrational Energy Flow in Hemeproteins

  Yasuhisa Mizutani; Naoki Fujii; Mitsuhiro Miyamoto; Misao Mizuno; Haruto Ishikawa

  ULTRAFAST PHENOMENA XIX, 2015, Peer-reviewed

  
• Protein Response to Chromophore Isomerization in Microbial Rhodopsins Revealed by Picosecond Time-Resolved Ultraviolet Resonance Raman Spectroscopy: A Review

  Mizuno, M.; Mizutani, Y.

  ACS Symposium Series, 2015, Peer-reviewed

  
• Direct Observation of Vibrational Energy Flow in Cytochrome c (vol 115, pg 13057, 2011)

  Naoki Fujii; Misao Mizuno; Yasuhisa Mizutani

  JOURNAL OF PHYSICAL CHEMISTRY B, May 2014, Peer-reviewed

  
• Observing vibrational energy flow in a protein with the spatial resolution of a single amino acid residue

  Fujii, N.; Mizuno, M.; Ishikawa, H.; Mizutani, Y.

  Journal of Physical Chemistry Letters, 2014, Peer-reviewed

  
• The early steps in the photocycle of a photosensor protein sensory rhodopsin i from Salinibacter ruber

  Sudo, Y.; Mizuno, M.; Wei, Z.; Takeuchi, S.; Tahara, T.; Mizutani, Y.

  Journal of Physical Chemistry B, 2014, Peer-reviewed

  
• 2P099 Protein dynamics of CooA upon CO dissociation studied by time-resolved resonance Raman spectroscopy(02. Heme proteins,Poster)

  Otomo Akihiro; Ishikawa Haruto; Mizuno Misao; Aono Shigetoshi; Mizutani Yasuhisa

  Seibutsu Butsuri, 2013

  
• Large spectral change due to amide modes of a β-sheet upon the formation of an early photointermediate of middle rhodopsin

  Furutani, Y.; Okitsu, T.; Reissig, L.; Mizuno, M.; Homma, M.; Wada, A.; Mizutani, Y.; Sudo, Y.

  Journal of Physical Chemistry B, 2013, Peer-reviewed

  
• Primary structural response in tryptophan residues of Anabaena sensory rhodopsin to photochromic reactions of the retinal chromophore

  Inada, S.; Mizuno, M.; Kato, Y.; Kawanabe, A.; Kandori, H.; Wei, Z.; Takeuchi, S.; Tahara, T.; Mizutani, Y.

  Chemical Physics, 2013, Peer-reviewed

  
• Ultraviolet resonance raman observations of the structural dynamics of rhizobial oxygen sensor FixL on ligand recognition

  Yano, S.; Ishikawa, H.; Mizuno, M.; Nakamura, H.; Shiro, Y.; Mizutani, Y.

  Journal of Physical Chemistry B, 2013, Peer-reviewed

  
• Intersubunit communication via changes in hemoglobin quaternary structures revealed by time-resolved resonance Raman spectroscopy: Direct observation of the perutz mechanism

  Yamada, K.; Ishikawa, H.; Mizuno, M.; Shibayama, N.; Mizutani, Y.

  Journal of Physical Chemistry B, 2013, Peer-reviewed

  
• Changes in the hydrogen-bond network around the chromophore of photoactive yellow protein in the ground and excited states

  Mizuno, M.; Kamikubo, H.; Kataoka, M.; Mizutani, Y.

  Journal of Physical Chemistry B, 2011, Peer-reviewed

  
• Direct observation of the structural change of Tyr174 in the primary reaction of sensory Rhodopsin II

  Mizuno, M.; Sudo, Y.; Homma, M.; Mizutani, Y.

  Biochemistry, 2011, Peer-reviewed

  
• Direct observation of vibrational energy flow in cytochrome c

  Fujii, N.; Mizuno, M.; Mizutani, Y.

  Journal of Physical Chemistry B, 2011, Peer-reviewed

  
• Protein conformational changes of the oxidative stress sensor, SoxR, upon redox changes of the [2Fe-2S] cluster probed with ultraviolet resonance raman spectroscopy

  Kobayashi, K.; Mizuno, M.; Fujikawa, M.; Mizutani, Y.

  Biochemistry, 2011, Peer-reviewed

  
• Primary Protein Responses to Chromophore Isomerization of Photosensary Proteins

  Yasuhisa Mizutani; Misao Mizuno

  XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY, 2010, Peer-reviewed

  
• Picosecond time-resolved ultraviolet resonance raman spectroscopy of bacteriorhodopsin: Primary protein response to the photoisomerization of Retinal

  Mizuno, M.; Shibata, M.; Yamada, J.; Kandori, H.; Mizutani, Y.

  Journal of Physical Chemistry B, 2009, Peer-reviewed

  
• Picosecond protein response to the chromophore isomerization of photoactive yellow protein: Selective observation of tyrosine and tryptophan residues by time-resolved ultraviolet resonance Raman spectroscopy

  Mizuno, M.; Hamada, N.; Tokunaga, F.; Mizutani, Y.

  Journal of Physical Chemistry B, 2007, Peer-reviewed

  
• Relaxation dynamics of the hydrated electron: Femtosecond time-resolved resonance Raman and luminescence study

  Mizuno, M.; Yamaguchi, S.; Tahara, T.

  Journal of Physical Chemistry A, 2005, Peer-reviewed

  
• Temporal fluorescence rejection in Raman spectroscopy using femtosecond up-conversion with single- and multi-channel detection

  Mandal, D.; Mizuno, M.; Tahara, T.

  Journal of Molecular Structure, 2005, Peer-reviewed

  
• Femtosecond dynamics of the solvated electron in water studied by time-resolved Raman spectroscopy

  Mizuno, M.; Yamaguchi, S.; Tahara, T.

  Femtochemistry and Femtobiology: Ultrafast Events in Molecular Science, 2004, Peer-reviewed

  
• Time-resolved infrared and resonance Raman studies of benzil. Vibrational analysis and structures of the excited states

  Mizuno, M.; Iwata, K.; Takahashi, H.

  Journal of Molecular Structure, 2003, Peer-reviewed

  
• Picosecond time-resolved resonance Raman study of the solvated electron in water

  Mizuno, M.; Tahara, T.

  Journal of Physical Chemistry A, 2003, Peer-reviewed

  
• Time-resolved absorption and time-resolved Raman spectroscopies of the photochemistry of carbazole and N-ethylcarbazole

  Hiyoshi, R.; Hiura, H.; Sakamoto, Y.; Mizuno, M.; Sakai, M.; Takahashi, H.

  Journal of Molecular Structure, 2003, Peer-reviewed

  
• Observation of resonance hyper-Raman scattering of all-trans-retinal

  Mizuno, M.; Hamaguchi, H.-O.; Tahara, T.

  Journal of Physical Chemistry A, 2002, Peer-reviewed

  
• Novel resonance Raman enhancement of local structure around solvated electrons in water

  Mizuno, M.; Tahara, T.

  Journal of Physical Chemistry A, 2001, Peer-reviewed

  
• Picosecond time-resolved absorption spectroscopy of luciferin

  Cherednikova, E.Y.; Chikishev, A.Y.; Kosobokova, O.V.; Mizuno, M.; Sakai, M.; Takahashi, H.

  Chemical Physics Letters, 1999, Peer-reviewed

  
• Picosecond-Nanosecond Time-Resolved Resonance Raman Study of the Structure and Dynamics of the Excited States of 5-Dibenzosuberene Derivatives

  Sakai, M.; Mizuno, M.; Takahashi, H.

  Journal of Raman Spectroscopy, 1998, Peer-reviewed

  
• Transient resonance Raman and ab initio MO calculation studies of the structures and vibrational assignments of the T1state and the anion radical of coumarin and its isotopically substituted analogues

  Uesugi, Y.; Mizuno, M.; Shimojima, A.; Takahashi, H.

  Journal of Physical Chemistry A, 1997, Peer-reviewed

  

Misc.

• Progress of Laser Technology and Observation of Ultrafast Protein Dynamics

  MIZUNO Misao; MIZUTANI Yasuhisa

  Seibutsu Butsuri, 2015

  
• Structural changes in the heme and heme pocket upon CO dissociation of CooA observed by time-resolved resonance Raman spectroscopy

  A. Otomo; H. Ishikawa; M. Mizuno; Y. Mizutani; S. Aono

  JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, Mar. 2014

  
• Dissipation Processes of "Heat" Energy in Protein Molecules

  水野 操; 水谷 泰久

  熱測定 = Calorimetry and thermal analysis, Oct. 2013

  
• Protein Response to Photoreaction Probed by Picosecond Time-resolved Ultraviolet Resonance Raman Spectroscopy

  MIZUTANI Yasuhisa; MIZUNO Misao

  Seibutsu Butsuri, 25 Jan. 2011

  
• Development of Time-Resolved Resonance Raman Spectrometer for Observation of Protein Dynamics

  MIZUNO Misao; MIZUTANI Yasuhisa

  The Review of Laser Engineering, 15 Oct. 2009

  
• Site-specific Observation of Dynamics in Biological Molecules Utilizing Resonance Effect

  MIZUNO Misao; MIZUTANI Yasuhisa

  Journal of the Spectroscopical Society of Japan, 15 Aug. 2008

  

Awards

• 24 May 2001

  Outstanding Poster Award
• 02 Sep. 2019

  2019年分子科学研究奨励森野基金受給者

External funds: Kakenhi

• Elucidation of intramolecular heat transfer mechanism for construction of highly effective photothermal protein heaters

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Osaka University

  Misao Mizuno

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  タンパク質ヒーター;光熱エネルギー変換;振動エネルギー移動;アンチストークスラマン散乱;時間分解共鳴ラマン分光法;ヘムタンパク質;アンチストークス散乱;分光学的温度計

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05756/
• Next generation non-invasive deep biological manipulation by combining biomolecular engineering and low physical energy logistics

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  The University of Tokyo

  Inoue Keiichi

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  深部生体操作;光熱変換;超音波;磁場;低物理エネルギーロジスティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-20H05755/
• Fine observations of the hydrogen-bond network driving ion transport using ultrafast spectroscopy

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Osaka University

  水野 操

  From 01 Apr. 2020, To 31 Mar. 2021, Discontinued

  時間分解共鳴ラマン分光法;水素結合ネットワーク;イオンポンプロドプシン

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05443/
• Visualizing protein motions using molecular photoswitching

  Grant-in-Aid for Scientific Research (B)

  Basic Section 32010:Fundamental physical chemistry-related

  Kyoto University;Osaka University

  水野 操

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  分子光スイッチング;時間分解共鳴ラマン分光法;タンパク質ダイナミクス;時間分解共鳴ラマン分光計測;時間分解紫外共鳴ラマン分光法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H02695/
• Development of observation of protein dynamics in nanometer region around an active center using molecular near-field vibrational spectroscopy

  Grant-in-Aid for Challenging Exploratory Research

  Osaka University

  Misao Mizuno

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  分子近接場振動分光法;共鳴ハイパーラマン散乱;分子の対称性;ヘム;ヘムタンパク質;対称中心;対称性;局所構造観測;ナノメートル構造;ダイナミクス観測

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K13933/
• タンパク質分子認識過程を活写する時間分解ラマン計測の光スイッチングによる超高速化

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Osaka University

  水野 操

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  分子認識;時間分解共鳴ラマン分光法;天然変性タンパク質;光スイッチング

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01639/
• Time-resolved Observation and Elucidation of Functionally-important Molecular Flexibility

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Osaka University

  Yasuhisa Mizutani

  From 28 Jun. 2013, To 31 Mar. 2018, Project Closed

  ラマン分光学;アロステリー;時間分解分光学;時間分解分光法

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25104006/
• Experimental elucidation of dynamic behaviors to facilitate protein functions

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  Misao MIZUNO

  From 28 Apr. 2011, To 31 Mar. 2015, Project Closed

  共鳴ラマン分光法;時間分解分光法;微生物型ロドプシン;タンパク質ダイナミクス;光異性化;イオン輸送;光センサー;古細菌型ロドプシン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23750015/
• Technical development of selective observation of proteins inliving cells by using ultraviolet resonance Raman spectroscopy

  Grant-in-Aid for Challenging Exploratory Research

  Osaka University

  Yasuhisa MIZUTANI

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  共鳴ラマン分光法;in-vivo測定;タンパク質構造

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23655012/
• センサータンパク質の信号伝達における共通立体構造の役割

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Osaka University

  水野 操

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  時間分解共鳴ラマン分光法;光受容タンパク質;古細菌型ロドプシン;光異性化;タンパク質応答;光センサータンパク質;BASドメイン構造;イエロープロテイン;変異体;水素結合;チロシン残基

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20038037/
• Elucidation of structural basis of dynamically-driven protein allostery by time-resolved resonance Raman spectroscopy

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Osaka University

  Yasuhisa MIZUTANI

  From 01 Apr. 2007, To 31 Mar. 2012, Project Closed

  ラマン分光法;生物物理学;時間分解分光学;共鳴ラマン分光法;時間分解分光法;アロステリックタンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19056013/
• Dynamic control of the interactive coupling between chemical reactions and structural changes in proteins

  Grant-in-Aid for Scientific Research (B)

  Basic Section 32010:Fundamental physical chemistry-related

  Kyoto University

  水野 操

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  電子移動反応;時間分解ラマン分光法;青色光受容タンパク質;構造ダイナミクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01436/
• 改変タンパク質が生成する新機能の時分割分光計測

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (II)

  University of Hyogo

  久保 稔

  From 01 Apr. 2024, To 31 Mar. 2029, Granted

  時分割赤外分光;時分割共鳴ラマン分光;X線小角散乱;タンパク質;動的構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24H02263/
• 光熱エネルギー変換タンパク質ヒーターによる細胞操作技術開発

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  水野 操

  From 28 Jun. 2024, To 31 Mar. 2026, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21930/
• Development of cell manupulation using photothermal protein heaters

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  水野 操

  From 28 Jun. 2024, To 31 Mar. 2026, Granted

  タンパク質ヒーター;光熱変換;細胞操作;ヘムタンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21930/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Fundamental Chemical Experiments

  N308, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Theoretical Chemistry IB

  7141, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Theoretical Chemistry IA

  7140, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Theoretical Chemistry ID

  7039, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Theoretical Chemistry ID

  7143, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Theoretical Chemistry IC

  7142, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Theoretical Chemistry IC

  7038, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Theoretical Chemistry IB

  7037, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Theoretical Chemistry IA

  7036, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Special study course II (Chemistry) 3

  5630, Year-long, Faculty of Science, 12
• From 01 Apr. 2024, To 31 Mar. 2025

  Exercises in Physical Chemistry A

  2625, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Chemical Laboratory B

  8635, Fall, Faculty of Science, 8
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Theoretical Chemistry IA

  7036, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Theoretical Chemistry ID

  7143, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Theoretical Chemistry ID

  7039, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Theoretical Chemistry IC

  7038, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Theoretical Chemistry IB

  7037, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Theoretical Chemistry IC

  7142, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Theoretical Chemistry IB

  7141, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Theoretical Chemistry IA

  7140, Spring, Graduate School of Science, 1

Part-time lecturer

• From 01 Apr. 2024, To 30 Sep. 2024

  東京工業大学
• From 01 Apr. 2024, To 31 Mar. 2025

  学習院大学, 理学部

Administration

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  理学研究科相談室運営委員会委員