Basic Information

Affiliated programs (koza)

• Graduate School of Pharmaceutical Sciences, 創発医薬科学専攻 創発医薬科学講座, 助教
• Graduate School of Medicine, 医学専攻 ケミカルバイオロジー, 助教

Academic Degree

• 修士（薬学）(東京大学)
• 博士（薬学）(東京大学)

ID,URL

• J-Global ID

  201801012721171988

researchmap URL

• https://researchmap.jp/7000024617

Research

Research Areas

• Life sciences, Bioorganic chemistry

Papers

• Covalent Plant Natural Product that Potentiates Antitumor Immunity

  Misao Takemoto; Sara Delghandi; Masahiro Abo; Keiko Yurimoto; Minami Odagi; Vaibhav Pal Singh; Jun Wang; Reiko Nakagawa; Shin-ichi Sato; Yasushi Takemoto; Asmaa M. A. S. Farrag; Yoshimasa Kawaguchi; Kazuo Nagasawa; Tasuku Honjo; Kenji Chamoto; Motonari Uesugi

  Journal of the American Chemical Society, 10 Jan. 2025

  
• 3P-321 Rational development of a fluorescence probe specific for hydroperoxides and its biological application(The 46th Annual Meeting of the Biophysical Society of Japan)

  Abo Masahiro; Urano Yasuteru; Nagano Tetsuo

  Seibutsu Butsuri, 2008

  
• Small-Molecule Drug Repurposing for Counteracting Phototoxic A2E Aggregation.

  Amelie Perron; Sathi Mandal; Thiago Negrão Chuba; Di Mao; Vaibhav Pal Singh; Naotaka Noda; Russell Tan; Hue Thi Vu; Masahiro Abo; Motonari Uesugi

  ACS chemical biology, 14 Sep. 2023

  
• Chemoproteomic Identification of Blue-Light-Damaged Proteins.

  Kohei Toh; Kosuke Nishio; Reiko Nakagawa; Syusuke Egoshi; Masahiro Abo; Amelie Perron; Shin-Ichi Sato; Naoki Okumura; Noriko Koizumi; Kosuke Dodo; Mikiko Sodeoka; Motonari Uesugi

  Journal of the American Chemical Society, 09 Nov. 2022

  
• Magnetic Control of Cells by Chemical Fabrication of Melanin.

  Kosuke Nishio; Kohei Toh; Amelie Perron; Masato Goto; Masahiro Abo; Yuichi Shimakawa; Motonari Uesugi

  Journal of the American Chemical Society, 21 Sep. 2022

  
• Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe.

  Yejin Jung; Naotaka Noda; Junichiro Takaya; Masahiro Abo; Kohei Toh; Ken Tajiri; Changyi Cui; Lu Zhou; Shin-Ichi Sato; Motonari Uesugi

  ACS chemical biology, 18 Feb. 2022

  
• Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis

  Yasushi Takemoto; Shin Kadota; Itsunari Minami; Shinya Otsuka; Satoshi Okuda; Masahiro Abo; Louvy Lynn Punzalan; Yan Shen; Yuji Shiba; Motonari Uesugi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 2021

  
• Identifying cysteine residues susceptible to oxidation by photoactivatable atomic oxygen precursors using a proteome-wide analysis.

  Ankita Isor; Benjamin V Chartier; Masahiro Abo; Emily R Currens; Eranthie Weerapana; Ryan D McCulla

  RSC chemical biology, 01 Apr. 2021

  
• Generation of Recombinant Mammalian Selenoproteins through Genetic Code Expansion with Photocaged Selenocysteine.

  Jennifer C Peeler; Julia A Falco; Rachel E Kelemen; Masahiro Abo; Benjamin V Chartier; Laura C Edinger; Jingjia Chen; Abhishek Chatterjee; Eranthie Weerapana

  ACS chemical biology, 19 Jun. 2020

  
• Isotopically-Labeled Iodoacetamide-Alkyne Probes for Quantitative Cysteine-Reactivity Profiling.

  Abo M; Li C; Weerapana E

  Molecular pharmaceutics, Mar. 2018, Peer-reviewed

  
• Chemical Probes for Redox Signaling and Oxidative Stress

  Masahiro Abo; Eranthie Weerapana

  ANTIOXIDANTS & REDOX SIGNALING, Dec. 2017, Peer-reviewed

  
• Optimization of Caged Electrophiles for Improved Monitoring of Cysteine Reactivity in Living Cells

  Masahiro Abo; Daniel W. Bak; Eranthie Weerapana

  CHEMBIOCHEM, Jan. 2017, Peer-reviewed

  
• A Caged Electrophilic Probe for Global Analysis of Cysteine Reactivity in Living Cells

  Masahiro Abo; Eranthie Weerapana

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2015, Peer-reviewed

  
• Visualization of Phagosomal Hydrogen Peroxide Production by a Novel Fluorescent Probe That Is Localized via SNAP-tag Labeling

  Masahiro Abo; Reiko Minakami; Kei Miyano; Mako Kamiya; Tetsuo Nagano; Yasuteru Urano; Hideki Sumimoto

  ANALYTICAL CHEMISTRY, Jun. 2014, Peer-reviewed

  
• A reversible near-infrared fluorescence probe for reactive oxygen species based on Te-rhodamine

  Yuichiro Koide; Mitsuyasu Kawaguchi; Yasuteru Urano; Kenjiro Hanaoka; Toru Komatsu; Masahiro Abo; Takuya Teraia; Tetsuo Nagano

  CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed

  
• Development of a Highly Sensitive Fluorescence Probe for Hydrogen Peroxide

  Masahiro Abo; Yasuteru Urano; Kenjiro Hanaoka; Takuya Terai; Toru Komatsu; Tetsuo Nagano

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2011, Peer-reviewed

  

Misc.

• Development of A Caged Cysteine-Reactive Probe for Characterizing Physiological Reactivity of Cysteine

  Masahiro Abo; Eranthie Weerapana

  FASEB JOURNAL, Apr. 2015

  
• Development of a Fluorescence Probe for Hydrogen Peroxide

  Masahiro Abo; Yasuteru Urano; Tetsuo Nagano

  FREE RADICAL BIOLOGY AND MEDICINE, 2010

  

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Organic Chemistry of Life

  N324, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Organic Chemistry of Life (Flipped Class)

  C019, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Organic Chemistry of Life

  N324, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Organic Chemistry of Life (Flipped Class)

  C019, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Organic Chemistry of Life (Flipped Class)

  C019, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Organic Chemistry of Life

  N324, Spring, Institute for Liberal Arts and Sciences, 2
• From Apr. 2019, To Mar. 2020

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Organic Chemistry of Life (Flipped Class)

  Fall, 薬学部

Part-time lecturer

• From 01 Oct. 2022, To 31 Mar. 2023

  生命有機化学演習

  大学院薬学研究科