Basic Information

Faculty

• 医学部

Academic Degree

• 農学修士(東京大学)
• 農学博士(東京大学)

Academic Resume (Graduate Schools)

• 東京大学, 大学院農学系研究科農芸化学専攻博士課程, 修了
• 東京大学, 大学院農学系研究科農芸化学専攻修士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 農学部農芸化学科, 卒業

ID,URL

• J-Global ID

  201401016215845895

researchmap URL

• https://researchmap.jp/7000008761

Research

Research Topics, Overview of the research

• Research Topics

  膜受容体の構造機能研究、膜輸送体の構造機能研究、膜蛋白質結晶構造解析のための技術開発

Research Areas

• Life sciences, Molecular biology

Papers

• Time-resolved small-angle X-ray scattering system development for the biological macromolecules at SACLA: A pilot study

  Nobutaka Shimizu; Fangjia Luo; Tomoyuki Tanaka; Kensuke Tono; Keiko Yatabe; So Iwata; Eriko Nango

  Biophysics and Physicobiology, 27 Mar. 2025

  
• 心脈管疾患の予防と治療の新戦略 立体構造から探るグレリン受容体の分子認識機構と活性化機構

  椎村 祐樹; 林 到げん; 谷猪 遼介; 浅田 秀基; 木瀬 亮二; 松井 一真; 佐藤 貴弘; 岩田 想; 増保 生郎; 児島 将康

  血管, Jan. 2025

  
• Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure

  Kano Suzuki; Yoshiyuki Goto; Akihiro Otomo; Kouki Shimizu; Shohei Abe; Katsuhiko Moriyama; Satoshi Yasuda; Yusuke Hashimoto; Jun Kurushima; Sho Mikuriya; Fabiana L. Imai; Naruhiko Adachi; Masato Kawasaki; Yumi Sato; Satoshi Ogasawara; So Iwata; Toshiya Senda; Mitsunori Ikeguchi; Haruyoshi Tomita; Ryota Iino; Toshio Moriya; Takeshi Murata

  Nature Structural & Molecular Biology, 21 Nov. 2024

  
• Discovering Key Activation Hotspots in the M2 Muscarinic Receptor.

  Yuya Sugiura; Tatsuya Ikuta; Yuji Sumii; Hirokazu Tsujimoto; Kohei Suzuki; Ryoji Suno; Putri Nur Arina Binti Mohd Ariff; So Iwata; Norio Shibata; Asuka Inoue; Takuya Kobayashi; Hideki Kandori; Kota Katayama

  Journal of the American Chemical Society, 14 Mar. 2025

  
• Recent progress in membrane protein dynamics revealed by X-ray free electron lasers: Molecular movies of microbial rhodopsins.

  Eriko Nango; So Iwata

  Current opinion in structural biology, Aug. 2023

  
• Structural effects of high laser power densities on an early bacteriorhodopsin photocycle intermediate.

  Quentin Bertrand; Przemyslaw Nogly; Eriko Nango; Demet Kekilli; Georgii Khusainov; Antonia Furrer; Daniel James; Florian Dworkowski; Petr Skopintsev; Sandra Mous; Isabelle Martiel; Per Börjesson; Giorgia Ortolani; Chia-Ying Huang; Michal Kepa; Dmitry Ozerov; Steffen Brünle; Valerie Panneels; Tomoyuki Tanaka; Rie Tanaka; Kensuke Tono; Shigeki Owada; Philip J M Johnson; Karol Nass; Gregor Knopp; Claudio Cirelli; Christopher Milne; Gebhard Schertler; So Iwata; Richard Neutze; Tobias Weinert; Jörg Standfuss

  Nature communications, 27 Nov. 2024

  
• 構造情報に立脚したグレリン受容体アゴニストの薬理プロファイル解析

  椎村 祐樹; イム・ドヒョン; 谷猪 遼介; 浅田 秀基; 松井 一真; 岩田 想; 増保 生郎; 児島 将康

  日本内分泌学会雑誌, Jun. 2024

  
• 構造情報を基づいたグレリン受容体アゴニストのシグナル活性の比較

  椎村 祐樹; イム・ドヒョン; 谷猪 遼介; 木瀬 亮次; 松井 一真; 浅田 秀基; 岩田 想; 児島 将康; 増保 生郎

  日本内分泌学会雑誌, Apr. 2024

  
• 肥満における5G(GLP-1、GIP、Glucagon、Ghrelin、Gut hormone) 基礎研究と臨床研究 グレリン受容体の構造的洞察(The 5Gs in Obesity(GLP-1, GIP, Glucagon, Ghrelin and Gut hormone): Basic and Clinical Research Structural Insights into Ghrelin Receptor)

  椎村 祐樹; Im Dohyun; Tany Ryosuke; Asada Hidetsugu; Matsui Kazuma; Masuho Ikuo; Iwata So; Kojima Masayasu

  肥満研究, Nov. 2023

  
• The structure and function of the ghrelin receptor coding for drug actions.

  Yuki Shiimura; Dohyun Im; Ryosuke Tany; Hidetsugu Asada; Ryoji Kise; Eon Kurumiya; Hideko Wakasugi-Masuho; Satoshi Yasuda; Kazuma Matsui; Jun-Ichi Kishikawa; Takayuki Kato; Takeshi Murata; Masayasu Kojima; So Iwata; Ikuo Masuho

  Nature structural & molecular biology, 20 Jan. 2025

  
• Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

  Chiyo Suno-Ikeda; Ryo Nishikawa; Riko Suzuki; Seiya Iwata; Tomoyo Takai; Takaya Ogura; Mika Hirose; Akitoshi Inoue; Eri Asai; Ryoji Kise; Yukihiko Sugita; Takayuki Kato; Hiroshi Nagase; Tsuyoshi Saitoh; Kota Katayama; Asuka Inoue; Hideki Kandori; Takuya Kobayashi; Ryoji Suno

  Apr. 2024

  
• Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution.

  Yugo Miyata; Katsuya Takahashi; Yongchan Lee; Cheryl S Sultan; Risa Kuribayashi; Masatomo Takahashi; Kosuke Hata; Takeshi Bamba; Yoshihiro Izumi; Kehong Liu; Tomoko Uemura; Norimichi Nomura; So Iwata; Shigekazu Nagata; Tomohiro Nishizawa; Katsumori Segawa

  Nature structural & molecular biology, 18 Oct. 2024

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• ヒスタミンH1受容体の結晶構造解析

  白石 充典; 島村 達郎; 辻本 浩一; 浅田 秀基; 小林 貴美[万木]; 小林 拓也; 岩田 想

  生化学, Oct. 2012

  
• GPCRの構造研究に向けた安定化改変体の作製・評価系の確立

  白石 充典; 島村 達郎; 辻本 浩一; 浅田 秀基; 小林 貴美[万木]; 小林 拓也; 岩田 想

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• アンジオテンシンタイプ2受容体の発現・精製から結晶構造解析へ向けて

  浅田 秀基; 小林 貴美; 白石 充典; 島村 達郎; 植村 智子; 辻本 浩一; 中根 崇智; 岩田 想; 小林 拓也

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• アンジオテンシンタイプ2受容体の発現と精製、および構造生物学のための構造認識抗体の作成(Expression and purification of Angiotensin receptor type 2 and production of structure recognition antibody for structural biology)

  浅田 秀基; 小林 貴美; 白石 充典; 島村 達郎; 植村 智子; 辻本 浩一; 飛田 直美; 中根 崇智; 岩成 宏子; 新井 修; 穐本 智; 中川 清; 浜窪 隆雄; 岩田 想; 小林 拓也

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• Neurotransmitter recognition by human vesicular monoamine transporter 2.

  Dohyun Im; Mika Jormakka; Narinobu Juge; Jun-Ichi Kishikawa; Takayuki Kato; Yukihiko Sugita; Takeshi Noda; Tomoko Uemura; Yuki Shiimura; Takaaki Miyaji; Hidetsugu Asada; So Iwata

  Nature communications, 16 Sep. 2024

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• Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography

  Basudev Maity; Mitsuo Shoji; Fangjia Luo; Takanori Nakane; Satoshi Abe; Shigeki Owada; Jungmin Kang; Kensuke Tono; Rie Tanaka; Thuc Toan Pham; Mariko Kojima; Yuki Hishikawa; Junko Tanaka; Jiaxin Tian; Misaki Nagama; Taiga Suzuki; Hiroki Noya; Yuto Nakasuji; Asuka Asanuma; Xinchen Yao; So Iwata; Yasuteru Shigeta; Eriko Nango; Takafumi Ueno

  Nature Communications, 29 Jun. 2024, Peer-reviewed

  
• 構造情報を基づいたグレリン受容体アゴニストのシグナル活性の比較

  椎村 祐樹; イム・ドヒョン; 谷猪 遼介; 木瀬 亮次; 松井 一真; 浅田 秀基; 岩田 想; 児島 将康; 増保 生郎

  日本内分泌学会雑誌, Apr. 2024

  
• In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A2A Receptor Antagonist/Inverse Agonist.

  Yutaro Ohno; Michihiko Suzuki; Hidetsugu Asada; Tomoyuki Kanda; Mayumi Saki; Hikaru Miyagi; Mai Yasunaga; Chiyo Suno; So Iwata; Jun-Ichi Saito; Shinichi Uchida

  Molecular pharmacology, Jun. 2023

  
• アゴニストと結合したグレリン受容体の構造に関する洞察(Insights into the Structure of the Agonist-bound Ghrelin Receptor)

  椎村 祐樹; イム・ドヒョン; 谷猪 遼介; 木瀬 亮次; 浅田 秀基; 岩田 想; 増保 生郎; 児島 将康

  日本内分泌学会雑誌, May 2023

  
• アゴニストと結合したグレリン受容体の立体構造

  椎村 祐樹; イム・ドヒョン; 浅田 秀基; 岩田 想; 児島 将康

  日本内分泌学会雑誌, Mar. 2023

  
• グレリン受容体の立体構造解析

  椎村 祐樹; 浅田 秀基; 岩田 想; 児島 将康

  日本内分泌学会雑誌, Mar. 2022

  
• スフィンゴシン-1-リン酸受容体におけるバイアスドアゴニズム機構

  前田 信太郎; 椎村 祐樹; 浅田 秀基; 平田 邦生; Luo Fangjia; 南後 恵理子; 井上 飛鳥; 青木 淳賢; 岩田 想; 萩原 正敏

  日本生化学会大会プログラム・講演要旨集, Nov. 2021

  
• 生理活性物質アンジオテンシンIIの結合によるアンジオテンシンII受容体活性化機構の構造基盤

  浅田 秀基; 井上 飛鳥; Francois Kadji M.N.; 平田 邦生; 椎村 祐樹; Dohyun Im; 青木 淳賢; 岩田 想

  日本生化学会大会プログラム・講演要旨集, Sep. 2019

  
• 中分子創薬研究のフロンティア 内分泌ペプチド創薬の新時代を切り拓く X線結晶構造解析を基盤とした活性型グレリン認識機構の解明

  椎村 祐樹; 堀田 彰一朗; 浅田 秀基; 平田 邦夫; 小林 拓也; 岩田 想; 児島 将康

  日本薬学会年会要旨集, Mar. 2019

  
• ヒトアンジオテンシンIIタイプ2受容体(AT2R)の立体構造解析へ向けた検討

  浅田 秀基; 平田 邦生; 白石 充典; 岩成 宏子; 浜窪 隆雄; 小林 拓也; 岩田 想

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• The Intervening Removable Affinity Tag (iRAT) System for the Production of Recombinant Antibody Fragments

  Norimichi Nomura; Yayoi Nomura; Yumi Sato; So Iwata

  Methods in Molecular Biology, 2021

  
• Crystallographic approaches to study the interaction modes of PD-1- and CTLA-4-blocking antibodies

  Norimichi Nomura; Yayoi Nomura; Yumi Sato; So Iwata

  Methods in Enzymology, 01 Jan. 2019

  
• Structural basis of hepatitis B virus receptor binding.

  Jinta Asami; Jae-Hyun Park; Yayoi Nomura; Chisa Kobayashi; Junki Mifune; Naito Ishimoto; Tomoko Uemura; Kehong Liu; Yumi Sato; Zhikuan Zhang; Masamichi Muramatsu; Takaji Wakita; David Drew; So Iwata; Toshiyuki Shimizu; Koichi Watashi; Sam-Yong Park; Norimichi Nomura; Umeharu Ohto

  Nature structural & molecular biology, Mar. 2024

  
• Oxygen-evolving photosystem II structures during S1–S2–S3 transitions

  Hongjie Li; Yoshiki Nakajima; Eriko Nango; Shigeki Owada; Daichi Yamada; Kana Hashimoto; Fangjia Luo; Rie Tanaka; Fusamichi Akita; Koji Kato; Jungmin Kang; Yasunori Saitoh; Shunpei Kishi; Huaxin Yu; Naoki Matsubara; Hajime Fujii; Michihiro Sugahara; Mamoru Suzuki; Tetsuya Masuda; Tetsunari Kimura; Tran Nguyen Thao; Shinichiro Yonekura; Long-Jiang Yu; Takehiko Tosha; Kensuke Tono; Yasumasa Joti; Takaki Hatsui; Makina Yabashi; Minoru Kubo; So Iwata; Hiroshi Isobe; Kizashi Yamaguchi; Michihiro Suga; Jian-Ren Shen

  Nature, 31 Jan. 2024, Peer-reviewed

  
• Molecular Movies using X-ray Free Electron Lasers: Recent Advances and Future Prospects

  NANGO Eriko; FUJIWARA Takaaki; FANGJIA Luo; IWATA So

  Nihon Kessho Gakkaishi, 15 Dec. 2022

  
• Time Resolved Crystallography Using X-ray Free Electron Laser on Photoreactive Membrane Proteins

  IWATA So; NANGO Eriko

  Seibutsu Butsuri, 2018

  
• Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor.

  Tsuyoshi Araya; Yuya Matsuba; Harufumi Suzuki; Tomohiro Doura; Nipawan Nuemket; Eriko Nango; Masaki Yamamoto; Dohyun Im; Hidetsugu Asada; Shigeki Kiyonaka; So Iwata

  Biochemical and biophysical research communications, 05 Feb. 2024

  
• Visualizing the DNA repair process by a photolyase at atomic resolution.

  Manuel Maestre-Reyna; Po-Hsun Wang; Eriko Nango; Yuhei Hosokawa; Martin Saft; Antonia Furrer; Cheng-Han Yang; Eka Putra Gusti Ngurah Putu; Wen-Jin Wu; Hans-Joachim Emmerich; Nicolas Caramello; Sophie Franz-Badur; Chao Yang; Sylvain Engilberge; Maximilian Wranik; Hannah Louise Glover; Tobias Weinert; Hsiang-Yi Wu; Cheng-Chung Lee; Wei-Cheng Huang; Kai-Fa Huang; Yao-Kai Chang; Jiahn-Haur Liao; Jui-Hung Weng; Wael Gad; Chiung-Wen Chang; Allan H Pang; Kai-Chun Yang; Wei-Ting Lin; Yu-Chen Chang; Dardan Gashi; Emma Beale; Dmitry Ozerov; Karol Nass; Gregor Knopp; Philip J M Johnson; Claudio Cirelli; Chris Milne; Camila Bacellar; Michihiro Sugahara; Shigeki Owada; Yasumasa Joti; Ayumi Yamashita; Rie Tanaka; Tomoyuki Tanaka; Fangjia Luo; Kensuke Tono; Wiktoria Zarzycka; Pavel Müller; Maisa Alkheder Alahmad; Filipp Bezold; Valerie Fuchs; Petra Gnau; Stephan Kiontke; Lukas Korf; Viktoria Reithofer; Christian Joshua Rosner; Elisa Marie Seiler; Mohamed Watad; Laura Werel; Roberta Spadaccini; Junpei Yamamoto; So Iwata; Dongping Zhong; Jörg Standfuss; Antoine Royant; Yoshitaka Bessho; Lars-Oliver Essen; Ming-Daw Tsai

  Science (New York, N.Y.), Dec. 2023

  
• Optical control of ultrafast structural dynamics in a fluorescent protein.

  Christopher D M Hutchison; James M Baxter; Ann Fitzpatrick; Gabriel Dorlhiac; Alisia Fadini; Samuel Perrett; Karim Maghlaoui; Salomé Bodet Lefèvre; Violeta Cordon-Preciado; Josie L Ferreira; Volha U Chukhutsina; Douglas Garratt; Jonathan Barnard; Gediminas Galinis; Flo Glencross; Rhodri M Morgan; Sian Stockton; Ben Taylor; Letong Yuan; Matthew G Romei; Chi-Yun Lin; Jon P Marangos; Marius Schmidt; Viktoria Chatrchyan; Tiago Buckup; Dmitry Morozov; Jaehyun Park; Sehan Park; Intae Eom; Minseok Kim; Dogeun Jang; Hyeongi Choi; HyoJung Hyun; Gisu Park; Eriko Nango; Rie Tanaka; Shigeki Owada; Kensuke Tono; Daniel P DePonte; Sergio Carbajo; Matt Seaberg; Andrew Aquila; Sebastien Boutet; Anton Barty; So Iwata; Steven G Boxer; Gerrit Groenhof; Jasper J van Thor

  Nature chemistry, Nov. 2023

  
• Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy

  Kayo Imamura; Ken-Ichi Akagi; Yohei Miyanoiri; Hirokazu Tsujimoto; Takatsugu Hirokawa; Hideo Ashida; Kaori Murakami; Asuka Inoue; Ryoji Suno; Takahisa Ikegami; Naotaka Sekiyama; So Iwata; Takuya Kobayashi; Hidehito Tochio

  Structure, Jan. 2024

  
• Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase.

  Cecilia Safari; Swagatha Ghosh; Rebecka Andersson; Jonatan Johannesson; Petra Båth; Owens Uwangue; Peter Dahl; Doris Zoric; Emil Sandelin; Adams Vallejos; Eriko Nango; Rie Tanaka; Robert Bosman; Per Börjesson; Elin Dunevall; Greger Hammarin; Giorgia Ortolani; Matthijs Panman; Tomoyuki Tanaka; Ayumi Yamashita; Toshi Arima; Michihiro Sugahara; Mamoru Suzuki; Tetsuya Masuda; Hanae Takeda; Raika Yamagiwa; Kazumasa Oda; Masahiro Fukuda; Takehiko Tosha; Hisashi Naitow; Shigeki Owada; Kensuke Tono; Osamu Nureki; So Iwata; Richard Neutze; Gisela Brändén

  Science advances, 08 Dec. 2023

  
• A versatile approach to high-density microcrystals in lipidic cubic phase for room-temperature serial crystallography.

  James Birch; Tristan O C Kwan; Peter J Judge; Danny Axford; Pierre Aller; Agata Butryn; Rosana I Reis; Juan F Bada Juarez; Javier Vinals; Robin L Owen; Eriko Nango; Rie Tanaka; Kensuke Tono; Yasumasa Joti; Tomoyuki Tanaka; Shigeki Owada; Michihiro Sugahara; So Iwata; Allen M Orville; Anthony Watts; Isabel Moraes

  Journal of applied crystallography, 01 Oct. 2023

  
• Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor.

  Dohyun Im; Jun-Ichi Kishikawa; Yuki Shiimura; Hiromi Hisano; Akane Ito; Yoko Fujita-Fujiharu; Yukihiko Sugita; Takeshi Noda; Takayuki Kato; Hidetsugu Asada; So Iwata

  Nature communications, 20 Oct. 2023

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• Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography

  Alexander M. Wolff; Eriko Nango; Iris D. Young; Aaron S. Brewster; Minoru Kubo; Takashi Nomura; Michihiro Sugahara; Shigeki Owada; Benjamin A. Barad; Kazutaka Ito; Asmit Bhowmick; Sergio Carbajo; Tomoya Hino; James M. Holton; Dohyun Im; Lee J. O’Riordan; Tomoyuki Tanaka; Rie Tanaka; Raymond G. Sierra; Fumiaki Yumoto; Kensuke Tono; So Iwata; Nicholas K. Sauter; James S. Fraser; Michael C. Thompson

  Nature Chemistry, 18 Sep. 2023

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• Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn2+ uptake into the Golgi apparatus.

  Han Ba Bui; Satoshi Watanabe; Norimichi Nomura; Kehong Liu; Tomoko Uemura; Michio Inoue; Akihisa Tsutsumi; Hiroyuki Fujita; Kengo Kinoshita; Yukinari Kato; So Iwata; Masahide Kikkawa; Kenji Inaba

  Nature communications, 08 Aug. 2023

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• 創薬ターゲット膜蛋白質の立体構造解析

  島村 達郎; 小笠原 諭; 岩田 想

  内分泌・糖尿病・代謝内科, 2012

  
• Serial Femtosecond Crystallography Reveals that Photoactivation in a Fluorescent Protein Proceeds via the Hula Twist Mechanism

  Alisia Fadini; Christopher D.M. Hutchison; Dmitry Morozov; Jeffrey Chang; Karim Maghlaoui; Samuel Perrett; Fangjia Luo; Jeslyn C.X. Kho; Matthew G. Romei; R. Marc L. Morgan; Christian M. Orr; Violeta Cordon-Preciado; Takaaki Fujiwara; Nipawan Nuemket; Takehiko Tosha; Rie Tanaka; Shigeki Owada; Kensuke Tono; So Iwata; Steven G. Boxer; Gerrit Groenhof; Eriko Nango; Jasper J. van Thor

  Journal of the American Chemical Society, 07 Jul. 2023, Peer-reviewed

  
• クライオ電子顕微鏡によるヒト由来メラトニン受容体シグナル伝達複合体の立体構造解析(Cryo-EM structure of the human MT1-Gi signaling complex)

  Okamoto Hiroyuki; Miyauchi Hirotake; Inoue Asuka; Raimondi Francesco; Tsujimoto Hirokazu; Kusakizako Tsukasa; Shihoya Wataru; Yamashita Keitaro; Suno Ryoji; Nomura Norimichi; Kobayashi Takuya; Iwata So; Nishizawa Tomohiro; Nureki Osamu

  生物物理, Aug. 2022

  
• Ultrafast structural changes direct the first molecular events of vision

  Thomas Gruhl; Tobias Weinert; Matthew J. Rodrigues; Christopher J. Milne; Giorgia Ortolani; Karol Nass; Eriko Nango; Saumik Sen; Philip J. M. Johnson; Claudio Cirelli; Antonia Furrer; Sandra Mous; Petr Skopintsev; Daniel James; Florian Dworkowski; Petra Båth; Demet Kekilli; Dmitry Ozerov; Rie Tanaka; Hannah Glover; Camila Bacellar; Steffen Brünle; Cecilia M. Casadei; Azeglio D. Diethelm; Dardan Gashi; Guillaume Gotthard; Ramon Guixà-González; Yasumasa Joti; Victoria Kabanova; Gregor Knopp; Elena Lesca; Pikyee Ma; Isabelle Martiel; Jonas Mühle; Shigeki Owada; Filip Pamula; Daniel Sarabi; Oliver Tejero; Ching-Ju Tsai; Niranjan Varma; Anna Wach; Sébastien Boutet; Kensuke Tono; Przemyslaw Nogly; Xavier Deupi; So Iwata; Richard Neutze; Jörg Standfuss; Gebhard Schertler; Valerie Panneels

  Nature, 22 Mar. 2023, Peer-reviewed

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• Lipidic cubic phase serial femtosecond crystallography structure of a photosynthetic reaction centre

  Petra Båth; Analia Banacore; Per Börjesson; Robert Bosman; Cecilia Wickstrand; Cecilia Safari; Robert Dods; Swagatha Ghosh; Peter Dahl; Giorgia Ortolani; Tinna Björg Ulfarsdottir; Greger Hammarin; María-José García Bonete; Adams Vallejos; Lucija Ostojić; Petra Edlund; Johanna-Barbara Linse; Rebecka Andersson; Eriko Nango; Shigeki Owada; Rie Tanaka; Kensuke Tono; Yasumasa Joti; Osamu Nureki; Fangjia Luo; Daniel James; Karol Nass; Philip J. M. Johnson; Gregor Knopp; Dmitry Ozerov; Claudio Cirelli; Christopher Milne; So Iwata; Gisela Brändén; Richard Neutze

  Acta Crystallographica Section D Structural Biology, 25 May 2022, Peer-reviewed

  
• Ambient temperature structure of phosphoketolase from Bifidobacterium longum determined by serial femtosecond X-ray crystallography

  Kunio Nakata; Tatsuki Kashiwagi; Naoki Kunishima; Hisashi Naitow; Yoshinori Matsuura; Hiroshi Miyano; Toshimi Mizukoshi; Kensuke Tono; Makina Yabashi; Eriko Nango; So Iwata

  Acta Crystallographica Section D Structural Biology, 28 Mar. 2023, Peer-reviewed

  
• Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota

  Titouan Jaunet-Lahary; Tatsuro Shimamura; Masahiro Hayashi; Norimichi Nomura; Kouta Hirasawa; Tetsuya Shimizu; Masao Yamashita; Naotaka Tsutsumi; Yuta Suehiro; Keiichi Kojima; Yuki Sudo; Takashi Tamura; Hiroko Iwanari; Takao Hamakubo; So Iwata; Kei-ichi Okazaki; Teruhisa Hirai; Atsuko Yamashita

  Nature Communications, 03 Apr. 2023, Peer-reviewed

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• Data processing pipeline for serial femtosecond crystallography at SACLA.

  Takanori Nakane; Yasumasa Joti; Kensuke Tono; Makina Yabashi; Eriko Nango; So Iwata; Ryuichiro Ishitani; Osamu Nureki

  Journal of applied crystallography, 01 Jun. 2016

  
• Expression, purification and characterization of isoforms of peripheral stalk subunits of human V-ATPase

  Suhaila Rahman; Yoshiko Ishizuka-Katsura; Satoshi Arai; Shinya Saijo; Ichiro Yamato; Mitsutoshi Toyama; Noboru Ohsawa; Mio Inoue; Keiko Honda; Takaho Terada; Mikako Shirouzu; Shigeyuki Yokoyama; So Iwata; Takeshi Murata

  Protein Expression and Purification, Aug. 2011, Peer-reviewed

  
• Serial femtosecond X-ray crystallography of an anaerobically formed catalytic intermediate of copper amine oxidase.

  Takeshi Murakawa; Mamoru Suzuki; Kenji Fukui; Tetsuya Masuda; Michihiro Sugahara; Kensuke Tono; Tomoyuki Tanaka; So Iwata; Eriko Nango; Takato Yano; Katsuyuki Tanizawa; Toshihide Okajima

  Acta crystallographica. Section D, Structural biology, 01 Dec. 2022, Peer-reviewed

  
• Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

  Muna Al-Habsi; Kenji Chamoto; Ken Matsumoto; Norimichi Nomura; Baihao Zhang; Yuki Sugiura; Kazuhiro Sonomura; Aprilia Maharani; Yuka Nakajima; Yibo Wu; Yayoi Nomura; Rosemary Menzies; Masaki Tajima; Koji Kitaoka; Yasuharu Haku; Sara Delghandi; Keiko Yurimoto; Fumihiko Matsuda; So Iwata; Toshihiko Ogura; Sidonia Fagarasan; Tasuku Honjo

  Science, 28 Oct. 2022, Peer-reviewed

  
• Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser.

  Xiaohong Liu; Pengcheng Liu; Hongjie Li; Zhen Xu; Lu Jia; Yan Xia; Minling Yu; Wenqin Tang; Xiaolei Zhu; Chao Chen; Yuanlin Zhang; Eriko Nango; Rie Tanaka; Fangjia Luo; Koji Kato; Yoshiki Nakajima; Shunpei Kishi; Huaxin Yu; Naoki Matsubara; Shigeki Owada; Kensuke Tono; So Iwata; Long-Jiang Yu; Jian-Ren Shen; Jiangyun Wang

  Nature chemistry, Sep. 2022, Peer-reviewed

  
• Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.

  Hidetsugu Asada; Dohyun Im; Yunhon Hotta; Satoshi Yasuda; Takeshi Murata; Ryoji Suno; So Iwata

  Structure (London, England : 1993), 01 Dec. 2022, Peer-reviewed

  
• Time-resolved serial femtosecond crystallography studies at an X-ray free electron laser reveals structural changes in bacteriorhodopsin

  Richard Neutze; Eriko Nango; Tomoyuki Tanaka; Takanori Nakane; So Iwata; Antoine Royant; Jörg St; fuss; Przemyslaw Nogly; Cecilia Wickstr

  Biochimica et Biophysica Acta (BBA) - Bioenergetics, Sep. 2018, Peer-reviewed

  
• Luciferin-regenerating enzyme solved by SIRAS using XFEL (refined against Hg derivative data)

  Yamashita K; Pan D; Okuda T; Sugahara M; Kodan A; Yamaguchi T; Murai T; Gomi K; Kajiyama N; Mizohata E; Suzuki M; Nango E; Tono K; Joti Y; Kameshima T; Park J; Song C; Hatsui T; Yabashi M; Iwata S; Kato H; Ago H; Yamamoto M; Nakatsu T

  Worldwide Protein Data Bank, 2015, Peer-reviewed

  
• Luciferin-regenerating enzyme solved by SAD using synchrotron radiation at room temperature

  Yamashita K; Pan D; Okuda T; Sugahara M; Kodan A; Yamaguchi T; Murai T; Gomi K; Kajiyama N; Mizohata E; Suzuki M; Nango E; Tono K; Joti Y; Kameshima T; Park J; Song C; Hatsui T; Yabashi M; Iwata S; Kato H; Ago H; Yamamoto M; Nakatsu T

  Worldwide Protein Data Bank, 2015, Peer-reviewed

  
• Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex

  Ryoji Suno; Yukihiko Sugita; Kazushi Morimoto; Hiroko Takazaki; Hirokazu Tsujimoto; Mika Hirose; Chiyo Suno-Ikeda; Norimichi Nomura; Tomoya Hino; Asuka Inoue; Kenji Iwasaki; Takayuki Kato; So Iwata; Takuya Kobayashi

  Cell Reports, Sep. 2022, Peer-reviewed

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• Structure of SARS-CoV-2 membrane protein essential for virus assembly.

  Zhikuan Zhang; Norimichi Nomura; Yukiko Muramoto; Toru Ekimoto; Tomoko Uemura; Kehong Liu; Moeko Yui; Nozomu Kono; Junken Aoki; Mitsunori Ikeguchi; Takeshi Noda; So Iwata; Umeharu Ohto; Toshiyuki Shimizu

  Nature communications, 05 Aug. 2022, Peer-reviewed

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• Structure of the bile acid transporter and HBV receptor NTCP.

  Jinta Asami; Kanako Terakado Kimura; Yoko Fujita-Fujiharu; Hanako Ishida; Zhikuan Zhang; Yayoi Nomura; Kehong Liu; Tomoko Uemura; Yumi Sato; Masatsugu Ono; Masaki Yamamoto; Takeshi Noda; Hideki Shigematsu; David Drew; So Iwata; Toshiyuki Shimizu; Norimichi Nomura; Umeharu Ohto

  Nature, Jun. 2022, Peer-reviewed

  
• Structure of Cytochrome c Oxidase from Paracoccus denitrificans at 2.8@90 Resolution

  IWATA So

  X-RAYS, 28 Feb. 1996

  
• High-throughput Crystallography of Drug-target Membrane Proteins

  IWATA So

  tits, 2012

  
• 新規競合阻害剤および混合型阻害剤との共結晶構造解析による酵母Type II NADH脱水素酵素Ndi1におけるユビキノン結合部位の同定

  山下 哲生; 稲岡 健ダニエル; 志波 智生; 大橋 拓未; 岩田 想; 矢木 隆雄; 小坂 博昭; 三芳 秀人; 原田 繁春; 北 潔; 平野 勝也

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• Introduction : Basic Biology

  IWATA So

  X-RAYS, 28 Feb. 2010

  
• 中分子創薬研究のフロンティア 内分泌ペプチド創薬の新時代を切り拓く X線結晶構造解析を基盤とした活性型グレリン認識機構の解明

  椎村 祐樹; 堀田 彰一朗; 浅田 秀基; 平田 邦夫; 小林 拓也; 岩田 想; 児島 将康

  日本薬学会年会要旨集, Mar. 2019, Peer-reviewed

  
• Author Correction: Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion.

  Kazuaki Matoba; Tetsuya Kotani; Akihisa Tsutsumi; Takuma Tsuji; Takaharu Mori; Daisuke Noshiro; Yuji Sugita; Norimichi Nomura; So Iwata; Yoshinori Ohsumi; Toyoshi Fujimoto; Hitoshi Nakatogawa; Masahide Kikkawa; Nobuo N Noda

  Nature structural & molecular biology, Dec. 2020

  
• 1SI-05 X-ray FEL and membrane protein crystallography(1SI Biophysics to be explored using the fourth-generation light sources, x-ray free electron lasers,The 49th Annual Meeting of the Biophysical Society of Japan)

  Iwata So

  Seibutsu Butsuri, 2011

  
• Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme

  Manuel Maestre-Reyna; Cheng-Han Yang; Eriko Nango; Wei-Cheng Huang; Eka Putra Gusti Ngurah Putu; Wen-Jin Wu; Po-Hsun Wang; Sophie Franz-Badur; Martin Saft; Hans-Joachim Emmerich; Hsiang-Yi Wu; Cheng-Chung Lee; Kai-Fa Huang; Yao-Kai Chang; Jiahn-Haur Liao; Jui-Hung Weng; Wael Gad; Chiung-Wen Chang; Allan H. Pang; Michihiro Sugahara; Shigeki Owada; Yuhei Hosokawa; Yasumasa Joti; Ayumi Yamashita; Rie Tanaka; Tomoyuki Tanaka; Fangjia Luo; Kensuke Tono; Kai-Cheng Hsu; Stephan Kiontke; Igor Schapiro; Roberta Spadaccini; Antoine Royant; Junpei Yamamoto; So Iwata; Lars-Oliver Essen; Yoshitaka Bessho; Ming-Daw Tsai

  NATURE CHEMISTRY, Apr. 2022, Peer-reviewed

  
• Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers.

  Toshiaki Hosaka; Takashi Nomura; Minoru Kubo; Takanori Nakane; Luo Fangjia; Shun-Ichi Sekine; Takuhiro Ito; Kazutaka Murayama; Kentaro Ihara; Haruhiko Ehara; Kazuhiro Kashiwagi; Kazushige Katsura; Ryogo Akasaka; Tamao Hisano; Tomoyuki Tanaka; Rie Tanaka; Toshi Arima; Ayumi Yamashita; Michihiro Sugahara; Hisashi Naitow; Yoshinori Matsuura; Susumu Yoshizawa; Kensuke Tono; Shigeki Owada; Osamu Nureki; Tomomi Kimura-Someya; So Iwata; Eriko Nango; Mikako Shirouzu

  Proceedings of the National Academy of Sciences of the United States of America, 01 Mar. 2022, Peer-reviewed

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• 3S5-5 Antibody Production for Membrane Protein Crystallization(3S5 Development of Protein Production and Structural Analysis technologies in the Targeted Proteins Research Program,The 46th Annual Meeting of the Biophysical Society of Japan)

  Iwata So

  Seibutsu Butsuri, 2008

  
• Structural insights into the HBV receptor and bile acid transporter NTCP.

  Jae-Hyun Park; Masashi Iwamoto; Ji-Hye Yun; Tomomi Uchikubo-Kamo; Donghwan Son; Zeyu Jin; Hisashi Yoshida; Mio Ohki; Naito Ishimoto; Kenji Mizutani; Mizuki Oshima; Masamichi Muramatsu; Takaji Wakita; Mikako Shirouzu; Kehong Liu; Tomoko Uemura; Norimichi Nomura; So Iwata; Koichi Watashi; Jeremy R H Tame; Tomohiro Nishizawa; Weontae Lee; Sam-Yong Park

  Nature, 17 May 2022, Peer-reviewed

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• Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2

  Rei Matsuoka; Roman Fudim; Sukkyeong Jung; Chenou Zhang; Andre Bazzone; Yurie Chatzikyriakidou; Carol V. Robinson; Norimichi Nomura; So Iwata; Michael Landreh; Laura Orellana; Oliver Beckstein; David Drew

  Nature Structural & Molecular Biology, Feb. 2022, Peer-reviewed

  
• Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R).

  Kota Katayama; Kohei Suzuki; Ryoji Suno; Ryoji Kise; Hirokazu Tsujimoto; So Iwata; Asuka Inoue; Takuya Kobayashi; Hideki Kandori

  Communications biology, 23 Nov. 2021, Peer-reviewed

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• The three-dimensional structure of Drosophila melanogaster (6-4) photolyase at room temperature.

  Andrea Cellini; Weixiao Yuan Wahlgren; Léocadie Henry; Suraj Pandey; Swagatha Ghosh; Leticia Castillon; Elin Claesson; Heikki Takala; Joachim Kübel; Amke Nimmrich; Valentyna Kuznetsova; Eriko Nango; So Iwata; Shigeki Owada; Emina A Stojković; Marius Schmidt; Janne A Ihalainen; Sebastian Westenhoff

  Acta crystallographica. Section D, Structural biology, 01 Aug. 2021, Peer-reviewed

  
• Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX

  Dongqing Pan; Ryo Oyama; Tomomi Sato; Takanori Nakane; Ryo Mizunuma; Keita Matsuoka; Yasumasa Joti; Kensuke Tono; Eriko Nango; So Iwata; Toru Nakatsu; Hiroaki Kato

  IUCrJ, 01 Jan. 2022, Peer-reviewed

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• Serial Femtosecond Crystallography at SACLA: Current Situation and Future Prospects

  NANGO Eriko; NAKANE Takanori; IWATA So

  Nihon Kessho Gakkaishi, 2017

  
• Molecular Basis of Alternating Access Membrane Transport by the Sodium-hydantoin Transporter Mhp1

  SHIMAMURA Tatsuro; IWATA So

  Seibutsu Butsuri, 2011

  
• Crystallization of Membrane Proteins

  Iwata So

  Journal of the Japanese Association for Crystal Growth, 2017

  
• Native sulfur/chlorine SAD phasing for serial femtosecond crystallography.

  Nakane T; Song C; Suzuki M; Nango E; Kobayashi J; Masuda T; Inoue S; Mizohata E; Nakatsu T; Tanaka T; Tanaka R; Shimamura T; Tono K; Joti Y; Kameshima T; Hatsui T; Yabashi M; Nureki O; Iwata S; Sugahara M

  Acta crystallographica. Section D, Biological crystallography, Dec. 2015, Peer-reviewed

  
• Structure determination of an integral membrane protein at room temperature from crystals in situ

  Danny Axford; James Foadi; Nien-Jen Hu; Hassanul Ghani Choudhury; So Iwata; Konstantinos Beis; Gwyndaf Evans; Yilmaz Alguel

  Acta Crystallographica Section D: Biological Crystallography, 01 Jun. 2015, Peer-reviewed

  
• Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase

  Takeshi Murakawa; Mamoru Suzuki; Toshi Arima; Michihiro Sugahara; Tomoyuki Tanaka; Rie Tanaka; So Iwata; Eriko Nango; Kensuke Tono; Hideyuki Hayashi; Kenji Fukui; Takato Yano; Katsuyuki Tanizawa; Toshihide Okajima

  Acta Crystallographica Section F Structural Biology Communications, 01 Oct. 2021, Peer-reviewed

  
• Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides

  Dmitry Ghilarov; Satomi Inaba-Inoue; Piotr Stepien; Feng Qu; Elizabeth Michalczyk; Zuzanna Pakosz; Norimichi Nomura; Satoshi Ogasawara; Graham Charles Walker; Sylvie Rebuffat; So Iwata; Jonathan Gardiner Heddle; Konstantinos Beis

  Science Advances, 10 Sep. 2021, Peer-reviewed

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• Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

  Koichiro E. Kishi; Yoon Seok Kim; Masahiro Fukuda; Tsukasa Kusakizako; Elina Thadhani; Eamon F.X. Byrne; Joseph M. Paggi; Charu Ramakrishnan; Toshiki E. Matsui; Keitaro Yamashita; Takashi Nagata; Masae Konno; Peter Y. Wang; Masatoshi Inoue; Tyler Benster; Tomoko Uemura; Kehong Liu; Mikihiro Shibata; Norimichi Nomura; So Iwata; Osamu Nureki; Ron O. Dror; Keiichi Inoue; Karl Deisseroth; Hideaki E. Kato

  15 Aug. 2021, Peer-reviewed

  
• Cryo-EM structure of the human MT1–Gi signaling complex

  Hiroyuki H. Okamoto; Hirotake Miyauchi; Asuka Inoue; Francesco Raimondi; Hirokazu Tsujimoto; Tsukasa Kusakizako; Wataru Shihoya; Keitaro Yamashita; Ryoji Suno; Norimichi Nomura; Takuya Kobayashi; So Iwata; Tomohiro Nishizawa; Osamu Nureki

  Nature Structural & Molecular Biology, 05 Aug. 2021, Peer-reviewed

  
• The structural basis of bacterial manganese import

  Stephanie L. Neville; Jennie Sjöhamn; Jacinta A. Watts; Hugo MacDermott-Opeskin; Stephen J. Fairweather; Katherine Ganio; Alex Carey Hulyer; Aaron P. McGrath; Andrew J. Hayes; Tess R. Malcolm; Mark R. Davies; Norimichi Nomura; So Iwata; Megan L. O’Mara; Megan J. Maher; Christopher A. McDevitt

  Science Advances, Aug. 2021, Peer-reviewed

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• High-resolution crystal structures of transient intermediates in the phytochrome photocycle

  Melissa Carrillo; Suraj Pandey; Juan Sanchez; Moraima Noda; Ishwor Poudyal; Luis Aldama; Tek Narsingh Malla; Elin Claesson; Weixiao Yuan Wahlgren; Denisse Feliz; Vukica Šrajer; Michał Maj; Leticia Castillon; So Iwata; Eriko Nango; Rie Tanaka; Tomoyuki Tanaka; Luo Fangjia; Kensuke Tono; Shigeki Owada; Sebastian Westenhoff; Emina A. Stojković; Marius Schmidt

  Structure, Jul. 2021, Peer-reviewed

  
• Endogenous agonist–bound S1PR3 structure reveals determinants of G protein–subtype bias

  Shintaro Maeda; Yuki Shiimura; Hidetsugu Asada; Kunio Hirata; Fangjia Luo; Eriko Nango; Nobuo Tanaka; Masayasu Toyomoto; Asuka Inoue; Junken Aoki; So Iwata; Masatoshi Hagiwara

  Science Advances, Jun. 2021, Peer-reviewed

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• Capturing structural changes of the S1 to S2 transition of photosystem II using time-resolved serial femtosecond crystallography

  Hongjie Li; Yoshiki Nakajima; Takashi Nomura; Michihiro Sugahara; Shinichiro Yonekura; Siu Kit Chan; Takanori Nakane; Takahiro Yamane; Yasufumi Umena; Mamoru Suzuki; Tetsuya Masuda; Taiki Motomura; Hisashi Naitow; Yoshinori Matsuura; Tetsunari Kimura; Kensuke Tono; Shigeki Owada; Yasumasa Joti; Rie Tanaka; Eriko Nango; Fusamichi Akita; Minoru Kubo; So Iwata; Jian-Ren Shen; Michihiro Suga

  IUCrJ, 01 May 2021, Peer-reviewed

  
• The structure of MgtE in the absence of magnesium provides new insights into channel gating

  Fei Jin; Minxuan Sun; Takashi Fujii; Yurika Yamada; Jin Wang; Andrés D. Maturana; Miki Wada; Shichen Su; Jinbiao Ma; Hironori Takeda; Tsukasa Kusakizako; Atsuhiro Tomita; Yoshiko Nakada-Nakura; Kehong Liu; Tomoko Uemura; Yayoi Nomura; Norimichi Nomura; Koichi Ito; Osamu Nureki; Keiichi Namba; So Iwata; Ye Yu; Motoyuki Hattori

  PLOS Biology, 27 Apr. 2021, Peer-reviewed

  
• Vibrational analysis of acetylcholine binding to the M-2 receptor

  Kohei Suzuki; Kota Katayama; Yuji Sumii; Tomoya Nakagita; Ryoji Suno; Hirokazu Tsujimoto; So Iwata; Takuya Kobayashi; Norio Shibata; Hideki Kandori

  RSC ADVANCES, Apr. 2021, Peer-reviewed

  
• Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin

  Kazumasa Oda; Takashi Nomura; Takanori Nakane; Keitaro Yamashita; Keiichi Inoue; Shota Ito; Johannes Vierock; Kunio Hirata; Andrés D Maturana; Kota Katayama; Tatsuya Ikuta; Itsuki Ishigami; Tamaki Izume; Rie Umeda; Ryuun Eguma; Satomi Oishi; Go Kasuya; Takafumi Kato; Tsukasa Kusakizako; Wataru Shihoya; Hiroto Shimada; Tomoyuki Takatsuji; Mizuki Takemoto; Reiya Taniguchi; Atsuhiro Tomita; Ryoki Nakamura; Masahiro Fukuda; Hirotake Miyauchi; Yongchan Lee; Eriko Nango; Rie Tanaka; Tomoyuki Tanaka; Michihiro Sugahara; Tetsunari Kimura; Tatsuro Shimamura; Takaaki Fujiwara; Yasuaki Yamanaka; Shigeki Owada; Yasumasa Joti; Kensuke Tono; Ryuichiro Ishitani; Shigehiko Hayashi; Hideki Kandori; Peter Hegemann; So Iwata; Minoru Kubo; Tomohiro Nishizawa; Osamu Nureki

  eLife, 23 Mar. 2021, Peer-reviewed

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• Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

  Shingo Nojima; Yoko Fujita; Kanako Terakado Kimura; Norimichi Nomura; Ryoji Suno; Kazushi Morimoto; Masaki Yamamoto; Takeshi Noda; So Iwata; Hideki Shigematsu; Takuya Kobayashi

  Structure, Mar. 2021, Peer-reviewed

  
• S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

  Masayasu Toyomoto; Asuka Inoue; Kei Iida; Masatsugu Denawa; Isao Kii; Francois Marie Ngako Kadji; Takayuki Kishi; Dohyun Im; Tatsuro Shimamura; Hiroshi Onogi; Suguru Yoshida; So Iwata; Junken Aoki; Takamitsu Hosoya; Masatoshi Hagiwara

  Cell Chemical Biology, Feb. 2021, Peer-reviewed

  
• Isolation and thermal stabilization of mouse ferroportin

  Chandrika N. Deshpande; Corbin R. Azucenas; Bo Qiao; Norimichi Nomura; Vicky Xin; Josep Font; So Iwata; Tomas Ganz; Elizabeta Nemeth; Bryan Mackenzie; Mika Jormakka

  FEBS Open Bio, Jan. 2021, Peer-reviewed

  
• Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone

  Dohyun Im; Asuka Inoue; Takaaki Fujiwara; Takanori Nakane; Yasuaki Yamanaka; Tomoko Uemura; Chihiro Mori; Yuki Shiimura; Kanako Terakado Kimura; Hidetsugu Asada; Norimichi Nomura; Tomoyuki Tanaka; Ayumi Yamashita; Eriko Nango; Kensuke Tono; Francois Marie Ngako Kadji; Junken Aoki; So Iwata; Tatsuro Shimamura

  Nature Communications, Dec. 2020, Peer-reviewed

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• Isoprenoid-chained lipid EROCOC17+4: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography

  Kentaro Ihara; Masakatsu Hato; Takanori Nakane; Keitaro Yamashita; Tomomi Kimura-Someya; Toshiaki Hosaka; Yoshiko Ishizuka-Katsura; Rie Tanaka; Tomoyuki Tanaka; Michihiro Sugahara; Kunio Hirata; Masaki Yamamoto; Osamu Nureki; Kensuke Tono; Eriko Nango; So Iwata; Mikako Shirouzu

  Scientific Reports, Dec. 2020, Peer-reviewed

  
• Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode

  Yuki Shiimura; Shoichiro Horita; Akie Hamamoto; Hidetsugu Asada; Kunio Hirata; Misuzu Tanaka; Kenji Mori; Tomoko Uemura; Takuya Kobayashi; So Iwata; Masayasu Kojima

  Nature Communications, Dec. 2020, Peer-reviewed

  
• The discovery of a new antibody for BRIL-fused GPCR structure determination.

  Hikaru Miyagi; Hidetsugu Asada; Michihiko Suzuki; Yuichi Takahashi; Mai Yasunaga; Chiyo Suno; So Iwata; Jun-Ichi Saito

  Scientific reports, 15 Jul. 2020, Peer-reviewed

  
• The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser

  Elin Claesson; Weixiao Yuan Wahlgren; Heikki Takala; Suraj Pandey; Leticia Castillon; Valentyna Kuznetsova; Léocadie Henry; Matthijs Panman; Melissa Carrillo; Joachim Kübel; Rahul Nanekar; Linnéa Isaksson; Amke Nimmrich; Andrea Cellini; Dmitry Morozov; Michał Maj; Moona Kurttila; Robert Bosman; Eriko Nango; Rie Tanaka; Tomoyuki Tanaka; Luo Fangjia; So Iwata; Shigeki Owada; Keith Moffat; Gerrit Groenhof; Emina A Stojković; Janne A Ihalainen; Marius Schmidt; Sebastian Westenhoff

  eLife, 31 Mar. 2020, Peer-reviewed

  
• Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

  Alexander M. Wolff; Iris D. Young; Raymond G. Sierra; Aaron S. Brewster; Michael W. Martynowycz; Eriko Nango; Michihiro Sugahara; Takanori Nakane; Kazutaka Ito; Andrew Aquila; Asmit Bhowmick; Justin T. Biel; Sergio Carbajo; Aina E. Cohen; Saul Cortez; Ana Gonzalez; Tomoya Hino; Dohyun Im; Jake D. Koralek; Minoru Kubo; Tomas S. Lazarou; Takashi Nomura; Shigeki Owada; Avi J. Samelson; Tomoyuki Tanaka; Rie Tanaka; Erin M. Thompson; Henry van den Bedem; Rahel A. Woldeyes; Fumiaki Yumoto; Wei Zhao; Kensuke Tono; Sebastien Boutet; So Iwata; Tamir Gonen; Nicholas K. Sauter; James S. Fraser; Michael C. Thompson

  IUCrJ, 01 Mar. 2020, Peer-reviewed

  
• Structural insights into tetraspanin CD9 function

  Rie Umeda; Yuhkoh Satouh; Mizuki Takemoto; Yoshiko Nakada-Nakura; Kehong Liu; Takeshi Yokoyama; Mikako Shirouzu; So Iwata; Norimichi Nomura; Ken Sato; Masahito Ikawa; Tomohiro Nishizawa; Osamu Nureki

  Nature Communications, Mar. 2020, Peer-reviewed

  
• Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

  Matoba K; Kotani T; Tsutsumi A; Tsuji T; Mori T; Noshiro D; Sugita Y; Nomura N; Iwata S; Ohsumi Y; Fujimoto T; Nakatogawa H; Kikkawa M; Noda NN

  Nat Struct Mol Biol., 2020, Peer-reviewed

  
• The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone

  Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Kunio Hirata; Yuki Shiimura; Dohyun Im; Tatsuro Shimamura; Norimichi Nomura; Hiroko Iwanari; Takao Hamakubo; Osamu Kusano-Arai; Hiromi Hisano; Tomoko Uemura; Chiyo Suno; Junken Aoki; So Iwata

  Structure, Dec. 2019, Peer-reviewed

  
• Ligand Binding-Induced Structural Changes in the M2 Muscarinic Acetylcholine Receptor Revealed by Vibrational Spectroscopy.

  Kota Katayama; Kohei Suzuki; Ryoji Suno; Hirokazu Tsujimoto; So Iwata; Takuya Kobayashi; Hideki Kandori

  The journal of physical chemistry letters, 21 Nov. 2019, Peer-reviewed

  
• Structures of the 5-HT 2A receptor in complex with the antipsychotics risperidone and zotepine

  Kanako Terakado Kimura; Hidetsugu Asada; Asuka Inoue; Francois Marie Ngako Kadji; Dohyun Im; Chihiro Mori; Takatoshi Arakawa; Kunio Hirata; Yayoi Nomura; Norimichi Nomura; Junken Aoki; So Iwata; Tatsuro Shimamura

  Nature Structural and Molecular Biology, 01 Feb. 2019, Peer-reviewed

  
• Bacteriorhodopsin: Structural Insights Revealed Using X-Ray Lasers and Synchrotron Radiation.

  Wickstrand C; Nogly P; Nango E; Iwata S; Standfuss J; Neutze R

  Annu Rev Biochem., 2019, Peer-reviewed

  
• Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.

  Yosuke Toyoda; Kazushi Morimoto; Ryoji Suno; Shoichiro Horita; Keitaro Yamashita; Kunio Hirata; Yusuke Sekiguchi; Satoshi Yasuda; Mitsunori Shiroishi; Tomoko Shimizu; Yuji Urushibata; Yuta Kajiwara; Tomoaki Inazumi; Yunhon Hotta; Hidetsugu Asada; Takanori Nakane; Yuki Shiimura; Tomoya Nakagita; Kyoshiro Tsuge; Suguru Yoshida; Tomoko Kuribara; Takamitsu Hosoya; Yukihiko Sugimoto; Norimichi Nomura; Miwa Sato; Takatsugu Hirokawa; Masahiro Kinoshita; Takeshi Murata; Kiyoshi Takayama; Masaki Yamamoto; Shuh Narumiya; So Iwata; Takuya Kobayashi

  Nature chemical biology, Jan. 2019, Peer-reviewed

  
• Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.

  Kazushi Morimoto; Ryoji Suno; Yunhong Hotta; Keitaro Yamashita; Kunio Hirata; Masaki Yamamoto; Shuh Narumiya; So Iwata; Takuya Kobayashi

  Nature chemical biology, Jan. 2019, Peer-reviewed

  
• Toward G protein-coupled receptor structure-based drug design using X-ray lasers

  Ishchenko A; Stauch B; Han GW; Batyuk A; Shiriaeva A; Li C; Zatsepin N; Weierstall U; Liu W; Nango E; Nakane T; Tanaka R; Tono K; Joti Y; Iwata S; Moraes I; Gati C; Cherezov V

  IUCrJ., 2019, Peer-reviewed

  
• High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure

  Shimazu Y; Tono K; Tanaka T; Yamanaka Y; Nakane T; Mori C; Terakado Kimura K; Fujiwara T; Sugahara M; Tanaka R; Doak RB; Shimamura T; Iwata S; Nango E; Yabashi M

  J. Appl. Cryst., 2019, Peer-reviewed

  
• Improvement of Production and Isolation of Human Neuraminidase-1 in Cellulo Crystals

  Koiwai K; Tsukimoto J; Higashi T; Mafune F; Miyajima K; Nakane T; Matsugaki N; Kato R; Sirigu S; Jakobi A; Wilmanns M; Sugahara M; Tanaka T; Tono K; Joti Y; Yabashi M; Nureki O; Mizohata E; Nakatsu T; Nango E; Iwata S; Chavas LMG; Senda T; Itoh K; Yumoto F

  ACS Appl. Bio Mater., 2019, Peer-reviewed

  
• High-resolution crystal structures of a myxobacterial phytochrome at cryo and room temperatures.

  Sanchez JC; Carrillo M; Pandey S; Noda M; Aldama L; Feliz D; Claesson E; Wahlgren WY; Tracy G; Duong P; Nugent AC; Field A; Šrajer V; Kupitz C; Iwata S; Nango E; Tanaka R; Tanaka T; Fangjia L; Tono K; Owada S; Westenhoff S; Schmidt M; Stojković EA

  Struct Dyn., 2019, Peer-reviewed

  
• FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics.

  Kinjo T; Terai K; Horita S; Nomura N; Sumiyama K; Togashi K; Iwata S; Matsuda M

  Nat Methods., 2019, Peer-reviewed

  
• Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor.

  Ryoji Suno; Sangbae Lee; Shoji Maeda; Satoshi Yasuda; Keitaro Yamashita; Kunio Hirata; Shoichiro Horita; Maki S Tawaramoto; Hirokazu Tsujimoto; Takeshi Murata; Masahiro Kinoshita; Masaki Yamamoto; Brian K Kobilka; Nagarajan Vaidehi; So Iwata; Takuya Kobayashi

  Nature chemical biology, Dec. 2018, Peer-reviewed

  
• Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab

  Masatsugu Ono; Shoichiro Horita; Yumi Sato; Yayoi Nomura; So Iwata; Norimichi Nomura

  Protein Science, 01 Jun. 2018, Peer-reviewed

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• An efficient screening method for purifying and crystallizing membrane proteins using modified clear-native PAGE.

  Nanao Suzuki; Yuuki Takamuku; Tomohiro Asakawa; Makoto Inai; Tomoya Hino; So Iwata; Toshiyuki Kan; Takeshi Murata

  Analytical biochemistry, 01 May 2018, Peer-reviewed

  
• Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.

  Ryoji Suno; Kanako Terakado Kimura; Takanori Nakane; Keitaro Yamashita; Junmei Wang; Takaaki Fujiwara; Yasuaki Yamanaka; Dohyun Im; Shoichiro Horita; Hirokazu Tsujimoto; Maki S Tawaramoto; Takatsugu Hirokawa; Eriko Nango; Kensuke Tono; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Makina Yabashi; Keiko Shimamoto; Masaki Yamamoto; Daniel M Rosenbaum; So Iwata; Tatsuro Shimamura; Takuya Kobayashi

  Structure (London, England : 1993), 02 Jan. 2018, Peer-reviewed

  
• Crystallization of Human Erythrocyte Band 3, the anion exchanger, at the International Space Station "KIBO″.

  Hatae H; Inaka K; Okamura R; Furubayashi N; Kamo M; Kobayashi T; Abe Y; Iwata S; Hamasaki N

  Anal Biochem., 2018, Peer-reviewed

  
• Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog

  Asada H; Horita S; Hirata K; Shiroishi M; Shiimura Y; Iwanari H; Hamakubo T; Shimamura T; Nomura N; Kusano-Arai O; Uemura T; Suno C; Kobayashi T; Iwata S

  NSMB, 2018, Peer-reviewed

  
• Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser

  Nogly P; Weinert T; James D; Carbajo S; Ozerov D; Furrer A; Gashi D; Borin V; Skopintsev P; Jaeger K; Nass K; Båth P; Bosman R; Koglin J; Seaberg M; Lane T; Kekilli D; Brünle S; Tanaka T; Wu W; Milne C; White T; Barty A; Weierstall U; Panneels V; Nango E; Iwata S; Hunter M; Schapiro I; Schertler G; Neutze R; Standfuss J

  Science, 2018, Peer-reviewed

  
• Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors.

  Yamashita, T; Inaoka, DK; Shiba, T; Oohashi, T; Iwata, S; Yagi, T; Kosaka, H; Miyoshi, H; Harada, S; Kita, K; Hirano, K

  Sci Rep., 2018, Peer-reviewed

  
• Generation of Conformation-Specific Antibody Fragments for Crystallization of the Multidrug Resistance Transporter MdfA

  Frank Jaenecke; Yoshiko Nakada-Nakura; Kumar Nagarathinam; Satoshi Ogasawara; Kehong Liu; Yunhon Hotta; So Iwata; Norimichi Nomura; Mikio Tanabe

  Methods in Molecular Biology, 2018, Peer-reviewed

  
• Outward open conformation of a Major Facilitator Superfamily multidrug/H+antiporter provides insights into switching mechanism.

  Nagarathinam K; Nakada-Nakura Y; Parthier C; Terada T; Juge N; Jaenecke F; Liu K; Hotta Y; Miyaji T; Omote H; Iwata S; Nomura N; Stubbs MT; Tanabe M

  Nat Commun., 2018, Peer-reviewed

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• Two-colour serial femtosecond crystallography dataset from gadoteridol-derivatized lysozyme for MAD phasing

  Alexander Gorel; Koji Motomura; Hironobu Fukuzawa; R. Bruce Doak; Marie Luise Gruenbein; Mario Hilpert; Ichiro Inoue; Marco Kloos; Gabriela Nass Kovacs; Eriko Nango; Karol Nass; Christopher M. Roome; Robert L. Shoeman; Rie Tanaka; Kensuke Tono; Lutz Foucar; Yasumasa Joti; Makina Yabashi; So Iwata; Kiyoshi Ueda; Thomas R. M. Barends; Ilme Schlichting

  SCIENTIFIC DATA, Dec. 2017, Peer-reviewed

  
• XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction

  Jessica L. Thomaston; Rahel A. Woldeyes; Takanori Nakane; Ayumi Yamashita; Tomoyuki Tanaka; Kotaro Koiwai; Aaron S. Brewster; Benjamin A. Barad; Yujie Chen; Thomas Lemmin; Monarin Uervirojnangkoorn; Toshi Arima; Jun Kobayashi; Tetsuya Masuda; Mamoru Suzuki; Michihiro Sugahara; Nicholas K. Sauter; Rie Tanaka; Osamu Nureki; Kensuke Tono; Yasumasa Joti; Eriko Nango; So Iwata; Fumiaki Yumoto; James S. Fraser; William F. DeGrado

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2017, Peer-reviewed

  
• Coincidence timing of femtosecond optical pulses in an X-ray free electron laser

  Alvaro Sanchez-Gonzalez; Allan S. Johnson; Ann Fitzpatrick; Christopher D. M. Hutchison; Clyde Fare; Violeta Cordon-Preciado; Gabriel Dorlhiac; Josie L. Ferreira; Rhodri M. Morgan; Jon P. Marangos; Shigeki Owada; Takanori Nakane; Rie Tanaka; Kensuke Tono; So Iwata; Jasper J. van Thor

  JOURNAL OF APPLIED PHYSICS, Nov. 2017, Peer-reviewed

  
• Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate

  Takehiko Tosha; Takashi Nomura; Takuma Nishida; Naoya Saeki; Kouta Okubayashi; Raika Yamagiwa; Michihiro Sugahara; Takanori Nakane; Keitaro Yamashita; Kunio Hirata; Go Ueno; Tetsunari Kimura; Tamao Hisano; Kazumasa Muramoto; Hitomi Sawai; Hanae Takeda; Eiichi Mizohata; Ayumi Yamashita; Yusuke Kanematsu; Yu Takano; Eriko Nango; Rie Tanaka; Osamu Nureki; Osami Shoji; Yuka Ikemoto; Hironori Murakami; Shigeki Owada; Kensuke Tono; Makina Yabashi; Masaki Yamamoto; Hideo Ago; So Iwata; Hiroshi Sugimoto; Yoshitsugu Shiro; Minoru Kubo

  NATURE COMMUNICATIONS, Nov. 2017, Peer-reviewed

  
• Multi-wavelength anomalous diffraction de novo phasing using a two-colour X-ray free-electron laser with wide tunability

  Alexander Gorel; Koji Motomura; Hironobu Fukuzawa; R. Bruce Doak; Marie Luise Gruenbein; Mario Hilpert; Ichiro Inoue; Marco Kloos; Gabriela Kovacsova; Eriko Nango; Karol Nass; Christopher M. Roome; Robert L. Shoeman; Rie Tanaka; Kensuke Tono; Yasumasa Joti; Makina Yabashi; So Iwata; Lutz Foucar; Kiyoshi Ueda; Thomas R. M. Barends; Ilme Schlichting

  NATURE COMMUNICATIONS, Oct. 2017, Peer-reviewed

  
• X-ray Free Electron Laser Determination of Crystal Structures of Dark and Light States of a Reversibly Photoswitching Fluorescent Protein at Room Temperature

  Christopher D. M. Hutchison; Violeta Cordon-Preciado; Rhodri M. L. Morgan; Takanori Nakane; Josie Ferreira; Gabriel Dorlhiac; Alvaro Sanchez-Gonzalez; Allan S. Johnson; Ann Fitzpatrick; Clyde Fare; Jon P. Marangos; Chun Hong Yoon; Mark S. Hunter; Daniel P. DePonte; Sebastien Boutet; Shigeki Owada; Rie Tanaka; Kensuke Tono; So Iwata; Jasper J. van Thor

  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Sep. 2017, Peer-reviewed

  
• Nanosecond pump-probe device for time-resolved serial femtosecond crystallography developed at SACLA

  Minoru Kubo; Eriko Nango; Kensuke Tono; Tetsunari Kimura; Shigeki Owada; Changyong Song; Fumitaka Mafune; Ken Miyajima; Yoshihiro Takeda; Jun-ya Kohno; Naoya Miyauchi; Takanori Nakane; Tomoyuki Tanaka; Takashi Nomura; Jan Davidsson; Rie Tanaka; Michio Murata; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Richard Neutze; Makina Yabashi; So Iwata

  JOURNAL OF SYNCHROTRON RADIATION, Sep. 2017, Peer-reviewed

  
• Experimental phase determination with selenomethionine or mercury-derivatization in serial femtosecond crystallography

  Keitaro Yamashita; Naoyuki Kuwabara; Takanori Nakane; Tomohiro Murai; Eiichi Mizohata; Michihiro Sugahara; Dongqing Pan; Tetsuya Masuda; Mamoru Suzuki; Tomomi Sato; Atsushi Kodan; Tomohiro Yamaguchi; Eriko Nango; Tomoyuki Tanaka; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Hiroshi Manya; Tamao Endo; Ryuichi Kato; Toshiya Senda; Hiroaki Kato; So Iwata; Hideo Ago; Masaki Yamamoto; Fumiaki Yumoto; Toru Nakatsu

  IUCRJ, Sep. 2017, Peer-reviewed

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• Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation

  Hisashi Naitow; Yoshinori Matsuura; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Rie Tanaka; Tomoyuki Tanaka; Michihiro Sugahara; Jun Kobayashi; Eriko Nango; So Iwata; Naoki Kunishima

  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, Aug. 2017, Peer-reviewed

  
• Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature

  Rebecka Andersson; Cecilia Safari; Robert Dods; Eriko Nango; Rie Tanaka; Ayumi Yamashita; Takanori Nakane; Kensuke Tono; Yasumasa Joti; Petra Bath; Elin Dunevall; Robert Bosman; Osamu Nureki; So Iwata; Richard Neutze; Gisela Branden

  SCIENTIFIC REPORTS, Jul. 2017, Peer-reviewed

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• Hot-Spot Residues to be Mutated Common in G Protein-Coupled Receptors of Class A: Identification of Thermostabilizing Mutations Followed by Determination of Three-Dimensional Structures for Two Example Receptors

  Satoshi Yasuda; Yuta Kajiwara; Yosuke Toyoda; Kazushi Morimoto; Ryoji Suno; So Iwata; Takuya Kobayashi; Takeshi Murata; Masahiro Kinoshita

  JOURNAL OF PHYSICAL CHEMISTRY B, Jul. 2017, Peer-reviewed

  
• Hydroxyethyl cellulose matrix applied to serial crystallography

  Michihiro Sugahara; Takanori Nakane; Tetsuya Masuda; Mamoru Suzuki; Shigeyuki Inoue; Changyong Song; Rie Tanaka; Toru Nakatsu; Eiichi Mizohata; Fumiaki Yumoto; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Osamu Nureki; Keiji Numata; Eriko Nango; So Iwata

  SCIENTIFIC REPORTS, Apr. 2017, Peer-reviewed

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• Atomic resolution structure of serine protease proteinase K at ambient temperature

  Tetsuya Masuda; Mamoru Suzuki; Shigeyuki Inoue; Changyong Song; Takanori Nakane; Eriko Nango; Rie Tanaka; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Bunzo Mikami; Osamu Nureki; Keiji Numata; So Iwata; Michihiro Sugahara

  SCIENTIFIC REPORTS, Mar. 2017, Peer-reviewed

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• Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL

  Michihiro Suga; Fusamichi Akita; Michihiro Sugahara; Minoru Kubo; Yoshiki Nakajima; Takanori Nakane; Keitaro Yamashita; Yasufumi Umena; Makoto Nakabayashi; Takahiro Yamane; Takamitsu Nakano; Mamoru Suzuki; Tetsuya Masuda; Shigeyuki Inoue; Tetsunari Kimura; Takashi Nomura; Shinichiro Yonekura; Long-Jiang Yu; Tomohiro Sakamoto; Taiki Motomura; Jing-Hua Chen; Yuki Kato; Takumi Noguchi; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Eriko Nango; Rie Tanaka; Hisashi Naitow; Yoshinori Matsuura; Ayumi Yamashita; Masaki Yamamoto; Osamu Nureki; Makina Yabashi; Tetsuya Ishikawa; So Iwata; Jian-Ren Shen

  NATURE, Mar. 2017, Peer-reviewed

  
• A three-dimensional movie of structural changes in bacteriorhodopsin

  Eriko Nango; Antoine Royant; Minoru Kubo; Takanori Nakane; Cecilia Wickstrand; Tetsunari Kimura; Tomoyuki Tanaka; Kensuke Tono; Changyong Song; Rie Tanaka; Toshi Arima; Ayumi Yamashita; Jun Kobayashi; Toshiaki Hosaka; Eiichi Mizohata; Przemyslaw Nogly; Michihiro Sugahara; Daewoong Nam; Takashi Nomura; Tatsuro Shimamura; Dohyun Im; Takaaki Fujiwara; Yasuaki Yamanaka; Byeonghyun Jeon; Tomohiro Nishizawa; Kazumasa Oda; Masahiro Fukuda; Rebecka Andersson; Petra Bath; Robert Dods; Jan Davidsson; Shigeru Matsuoka; Satoshi Kawatake; Michio Murata; Osamu Nureki; Shigeki Owada; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Gebhard Schertler; Makina Yabashi; Ana-Nicoleta Bondar; Jorg Standfuss; Richard Neutze; So Iwata

  SCIENCE, Dec. 2016, Peer-reviewed

  
• Crystal structures of the TRIC trimeric intracellular cation channel orthologues

  Go Kasuya; Masahiro Hiraizumi; Andres D. Maturana; Kaoru Kumazaki; Yuichiro Fujiwara; Keihong Liu; Yoshiko Nakada-Nakura; So Iwata; Keisuke Tsukada; Tomotaka Komori; Sotaro Uemura; Yuhei Goto; Takanori Nakane; Mizuki Takemoto; Hideaki E. Kato; Keitaro Yamashita; Miki Wada; Koichi Ito; Ryuichiro Ishitani; Motoyuki Hattori; Osamu Nureki

  CELL RESEARCH, Dec. 2016, Peer-reviewed

  
• METHODS AND APPLICATIONS The intervening removable affinity tag (iRAT) production system facilitates Fv antibody fragment-mediated crystallography

  Yayoi Nomura; Yumi Sato; Ryoji Suno; Shoichiro Horita; So Iwata; Norimichi Nomura

  PROTEIN SCIENCE, Dec. 2016, Peer-reviewed

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• Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent

  Takanori Nakane; Shinya Hanashima; Mamoru Suzuki; Haruka Saiki; Taichi Hayashi; Keisuke Kakinouchi; Shigeru Sugiyama; Satoshi Kawatake; Shigeru Matsuoka; Nobuaki Matsumori; Eriko Nango; Jun Kobayashi; Tatsuro Shimamura; Kanako Kimura; Chihiro Mori; Naoki Kunishima; Michihiro Sugahara; Yoko Takakyu; Shigeyuki Inoue; Tetsuya Masuda; Toshiaki Hosaka; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Tsuyoshi Inoue; Osamu Nureki; So Iwata; Michio Murata; Eiichi Mizohata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2016, Peer-reviewed

  
• High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1

  Shoichiro Horita; Yayoi Nomura; Yumi Sato; Tatsuro Shimamura; So Iwata; Norimichi Nomura

  SCIENTIFIC REPORTS, Oct. 2016, Peer-reviewed

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• Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography

  Przemyslaw Nogly; Valerie Panneels; Garrett Nelson; Cornelius Gati; Tetsunari Kimura; Christopher Milne; Despina Milathianaki; Minoru Kubo; Wenting Wu; Chelsie Conrad; Jesse Coe; Richard Bean; Yun Zhao; Petra Bath; Robert Dods; Rajiv Harimoorthy; Kenneth R. Beyerlein; Jan Rheinberger; Daniel James; Daniel DePonte; Chufeng Li; Leonardo Sala; Garth J. Williams; Mark S. Hunter; Jason E. Koglin; Peter Berntsen; Eriko Nango; So Iwata; Henry N. Chapman; Petra Fromme; Matthias Frank; Rafael Abela; Sebastien Boutet; Anton Barty; Thomas A. White; Uwe Weierstall; John Spence; Richard Neutze; Gebhard Schertler; Jorg Standfuss

  NATURE COMMUNICATIONS, Aug. 2016, Peer-reviewed

  
• Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context

  Reinhart A. F. Reithmeier; Joseph R. Casey; Antreas C. Kalli; Mark S. P. Sansom; Yilmaz Alguel; So Iwata

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jul. 2016, Peer-reviewed

  
• Data processing pipeline for serial femtosecond crystallography at SACLA

  Takanori Nakane; Yasumasa Joti; Kensuke Tono; Makina Yabashi; Eriko Nango; So Iwata; Ryuichiro Ishitani; Osamu Nureki

  JOURNAL OF APPLIED CRYSTALLOGRAPHY, Jun. 2016, Peer-reviewed

  
• Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography

  Yohta Fukuda; Ka Man Tse; Mamoru Suzuki; Kay Diederichs; Kunio Hirata; Takanori Nakane; Michihiro Sugahara; Eriko Nango; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Changyong Song; Takaki Hatsui; Makina Yabashi; Osamu Nureki; Hiroyoshi Matsumura; Tsuyoshi Inoue; So Iwata; Eiichi Mizohata

  JOURNAL OF BIOCHEMISTRY, May 2016, Peer-reviewed

  
• Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity

  Yilmaz Alguel; Sotiris Amillis; James Leung; George Lambrinidis; Stefano Capaldi; Nicola J. Scull; Gregory Craven; So Iwata; Alan Armstrong; Emmanuel Mikros; George Diallinas; Alexander D. Cameron; Bernadette Byrne

  NATURE COMMUNICATIONS, Apr. 2016, Peer-reviewed

  
• Oil-free hyaluronic acid matrix for serial femtosecond crystallography

  Michihiro Sugahara; Changyong Song; Mamoru Suzuki; Tetsuya Masuda; Shigeyuki Inoue; Takanori Nakane; Fumiaki Yumoto; Eriko Nango; Rie Tanaka; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Osamu Nureki; Keiji Numata; So Iwata

  SCIENTIFIC REPORTS, Apr. 2016, Peer-reviewed

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• Microcrystal delivery by pulsed liquid droplet for serial femtosecond crystallography

  Fumitaka Mafune; Ken Miyajima; Kensuke Tono; Yoshihiro Takeda; Jun-ya Kohno; Naoya Miyauchi; Jun Kobayashi; Yasumasa Joti; Eriko Nango; So Iwata; Makina Yabashi

  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, Apr. 2016, Peer-reviewed

  
• Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

  Yasuaki Kabe; Takanori Nakane; Ikko Koike; Tatsuya Yamamoto; Yuki Sugiura; Erisa Harada; Kenji Sugase; Tatsuro Shimamura; Mitsuyo Ohmura; Kazumi Muraoka; Ayumi Yamamoto; Takeshi Uchida; So Iwata; Yuki Yamaguchi; Elena Krayukhina; Masanori Noda; Hiroshi Handa; Koichiro Ishimori; Susumu Uchiyama; Takuya Kobayashi; Makoto Suematsu

  NATURE COMMUNICATIONS, Mar. 2016, Peer-reviewed

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• Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography

  Yohta Fukuda; Ka Man Tsea; Takanori Nakane; Toru Nakatsu; Mamoru Suzuki; Michihiro Sugahara; Shigeyuki Inoue; Tetsuya Masuda; Fumiaki Yumoto; Naohiro Matsugaki; Eriko Nango; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Changyong Song; Takaki Hatsui; Makina Yabashi; Osamu Nureki; Michael E. P. Murphy; Tsuyoshi Inoue; So Iwata; Eiichi Mizohata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2016, Peer-reviewed

  
• Native sulfur/chlorine SAD phasing for serial femtosecond crystallography

  Takanori Nakane; Changyong Song; Mamoru Suzuki; Eriko Nango; Jun Kobayashi; Tetsuya Masuda; Shigeyuki Inoue; Eiichi Mizohata; Toru Nakatsu; Tomoyuki Tanaka; Rie Tanaka; Tatsuro Shimamura; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Takaki Hatsui; Makina Yabashi; Osamu Nureki; So Iwata; Michihiro Sugahara

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Dec. 2015, Peer-reviewed

  
• Crystal structure of the anion exchanger domain of human erythrocyte band 3

  Takatoshi Arakawa; Takami Kobayashi-Yurugi; Yilmaz Alguel; Hiroko Iwanari; Hinako Hatae; Momi Iwata; Yoshito Abe; Tomoya Hino; Chiyo Ikeda-Suno; Hiroyuki Kuma; Dongchon Kang; Takeshi Murata; Takao Hamakubo; Alexander D. Cameron; Takuya Kobayashi; Naotaka Hamasaki; So Iwata

  SCIENCE, Nov. 2015, Peer-reviewed

  
• Structure and mechanism of the mammalian fructose transporter GLUT5

  Norimichi Nomura; Gregory Verdon; Hae Joo Kang; Tatsuro Shimamura; Yayoi Nomura; Yo Sonoda; Saba Abdul Hussien; Aziz Abdul Qureshi; Mathieu Coincon; Yumi Sato; Hitomi Abe; Yoshiko Nakada-Nakura; Tomoya Hino; Takatoshi Arakawa; Osamu Kusano-Arai; Hiroko Iwanari; Takeshi Murata; Takuya Kobayashi; Takao Hamakubo; Michihiro Kasahara; So Iwata; David Drew

  NATURE, Oct. 2015, Peer-reviewed

  
• An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography

  Keitaro Yamashita; Dongqing Pan; Tomohiko Okuda; Michihiro Sugahara; Atsushi Kodan; Tomohiro Yamaguchi; Tomohiro Murai; Keiko Gomi; Naoki Kajiyama; Eiichi Mizohata; Mamoru Suzuki; Eriko Nango; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Jaehyun Park; Changyong Song; Takaki Hatsui; Makina Yabashi; So Iwata; Hiroaki Kato; Hideo Ago; Masaki Yamamoto; Toru Nakatsu

  SCIENTIFIC REPORTS, Sep. 2015, Peer-reviewed

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• Structure determination of an integral membrane protein at room temperature from crystals in situ

  Danny Axford; James Foadi; Nien-Jen Hu; Hassanul Ghani Choudhury; So Iwata; Konstantinos Beis; Gwyndaf Evans; Yilmaz Alguel

  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, Jun. 2015, Peer-reviewed

  
• Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser

  Kensuke Tono; Eriko Nango; Michihiro Sugahara; Changyong Song; Jaehyun Park; Tomoyuki Tanaka; Rie Tanaka; Yasumasa Joti; Takashi Kameshima; Shun Ono; Takaki Hatsui; Eiichi Mizohata; Mamoru Suzuki; Tatsuro Shimamura; Yoshiki Tanaka; So Iwata; Makina Yabashi

  JOURNAL OF SYNCHROTRON RADIATION, May 2015, Peer-reviewed

  
• Crystal structures of the human adiponectin receptors

  Hiroaki Tanabe; Yoshifumi Fujii; Miki Okada-Iwabu; Masato Iwabu; Yoshihiro Nakamura; Toshiaki Hosaka; Kanna Motoyama; Mariko Ikeda; Motoaki Wakiyama; Takaho Terada; Noboru Ohsawa; Masakatsu Hato; Satoshi Ogasawara; Tomoya Hino; Takeshi Murata; So Iwata; Kunio Hirata; Yoshiaki Kawano; Masaki Yamamoto; Tomomi Kimura-Someya; Mikako Shirouzu; Toshimasa Yamauchi; Takashi Kadowaki; Shigeyuki Yokoyama

  NATURE, Apr. 2015, Peer-reviewed

  
• Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2

  Hiroaki Tanabe; Kanna Motoyama; Mariko Ikeda; Motoaki Wakiyama; Takaho Terada; Noboru Ohsawa; Toshiaki Hosaka; Masakatsu Hato; Yoshifumi Fujii; Yoshihiro Nakamura; Satoshi Ogasawara; Tomoya Hino; Takeshi Murata; So Iwata; Miki Okada-Iwabu; Masato Iwabu; Kunio Hirata; Yoshiaki Kawano; Masaki Yamamoto; Tomomi Kimura-Someya; Mikako Shirouzu; Toshimasa Yamauchi; Takashi Kadowaki; Shigeyuki Yokoyama

  Journal of Structural and Functional Genomics, Mar. 2015, Peer-reviewed

  
• GFP-Based Expression Screening of Membrane Proteins in Insect Cells Using the Baculovirus System

  Hu, N-Jen; Rada, H; Rahman, N; Nettleship, J.E; Bird, L; Iwata, S; Drew, D; Cameron, A.D; Owens, R.J

  Springer, 2015, Peer-reviewed

  
• Grease matrix as a versatile carrier of proteins for serial crystallography

  Michihiro Sugahara; Eiichi Mizohata; Eriko Nango; Mamoru Suzuki; Tomoyuki Tanaka; Tetsuya Masudala; Rie Tanaka; Tatsuro Shimamura; Yoshiki Tanaka; Chiyo Suno; Kentaro Ihara; Dongqing Pan; Keisuke Kakinouchi; Shigeru Sugiyama; Michio Murata; Tsuyoshi Inoue; Kensuke Tono; Changyong Song; Jaehyun Park; Takashi Kameshima; Takaki Hatsui; Yasumasa Joti; Makina Yabashi; So Iwata

  NATURE METHODS, Jan. 2015, Peer-reviewed

  
• Proteoliposome-based Selection of a Recombinant Antibody Fragment Against the Human M2 Muscarinic Acetylcholine Receptor

  Suharni; Yayoi Nomura; Takatoshi Arakawa; Tomoya Hino; Hitomi Abe; Yoshiko Nakada-Nakura; Yumi Sato; Hiroko Iwanari; Mitsunori Shiroishi; Hidetsugu Asada; Tatsuro Shimamura; Takeshi Murata; Takuya Kobayashi; Takao Hamakubo; So Iwata; Norimichi Nomura

  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Dec. 2014, Peer-reviewed

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• Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights

  Chiara Lee; Shoko Yashiro; David L. Dotson; Povilas Uzdavinys; So Iwata; Mark S. P. Sansom; Christoph von Ballmoos; Oliver Beckstein; David Drew; Alexander D. Cameron

  JOURNAL OF GENERAL PHYSIOLOGY, Dec. 2014, Peer-reviewed

  
• In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology?

  Francois-Xavier Gallat; Naohiro Matsugaki; Nathan P. Coussens; Koichiro J. Yagi; Marion Boudes; Tetsuya Higashi; Daisuke Tsuji; Yutaka Tatano; Mamoru Suzuki; Eiichi Mizohata; Kensuke Tono; Yasumasa Joti; Takashi Kameshima; Jaehyun Park; Changyong Song; Takaki Hatsui; Makina Yabashi; Eriko Nango; Kohji Itoh; Fasseli Coulibaly; Stephen Tobe; S. Ramaswamy; Barbara Stay; So Iwata; Leonard M. G. Chavas

  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Jul. 2014, Peer-reviewed

  
• Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

  Hassanul G. Choudhury; Zhen Tong; Indran Mathavan; Yanyan Li; So Iwata; Severine Zirah; Sylvie Rebuffat; Hendrik W. van Veen; Konstantinos Beis

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2014, Peer-reviewed

  
• Molecular mechanism of ligand recognition by membrane transport protein, Mhp1

  Simmons, KJ; Jackson, SM; Brueckner, F; Patching, SG; Beckstein, O; Ivanova, E; Geng, T; Weyand, S; Drew, D; Lanigan, J; Sharples, DJ; Sansom, MS; Iwata, S; Fishwick, CW; Johnson, AP; Cameron, A.D; Henderson, PJ

  EMBO, 2014, Peer-reviewed

  
• Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

  Ioannis Manolaridis; Kiran Kulkarni; Roger B. Dodd; Satoshi Ogasawara; Ziguo Zhang; Ganka Bineva; Nicola O'Reilly; Sarah J. Hanrahan; Andrew J. Thompson; Nora Cronin; So Iwata; David Barford

  NATURE, Dec. 2013, Peer-reviewed

  
• Loose Binding of the DF Axis with the A3B3 Complex Stimulates the Initial Activity of Enterococcus hirae V1-ATPase

  Md. Jahangir Alam; Satoshi Arai; Shinya Saijo; Kano Suzuki; Kenji Mizutani; Yoshiko Ishizuka-Katsura; Noboru Ohsawa; Takaho Terada; Mikako Shirouzu; Shigeyuki Yokoyama; So Iwata; Yoshimi Kakinuma; Ichiro Yamato; Takeshi Murata

  PLoS ONE, 13 Sep. 2013, Peer-reviewed

  
• A two-domain elevator mechanism for sodium/proton antiport

  Chiara Lee; Hae Joo Kang; Christoph von Ballmoos; Simon Newstead; Povilas Uzdavinys; David L. Dotson; So Iwata; Oliver Beckstein; Alexander D. Cameron; David Drew

  NATURE, Sep. 2013, Peer-reviewed

  
• Generation of functional antibodies for mammalian membrane protein crystallography

  Tomoya Hino; So Iwata; Takeshi Murata

  CURRENT OPINION IN STRUCTURAL BIOLOGY, Aug. 2013, Peer-reviewed

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• Synthesis of photoreactive 2-phenethylamine derivatives-synthesis of adenosine derivatives enabling functional analysis of adenosine receptors by photoaffinity labeling

  Yuta Murai; Katsuyoshi Masuda; Yui Ogasawara; Lei Wang; Yasuyuki Hashidoko; Yasumaru Hatanaka; So Iwata; Takuya Kobayashi; Makoto Hashimoto

  European Journal of Organic Chemistry, Apr. 2013, Peer-reviewed

  
• Biochemical and Biophysical Properties of Interactions between Subunits of the Peripheral Stalk Region of Human V-ATPase

  Suhaila Rahman; Ichiro Yamato; Shinya Saijo; Kenji Mizutani; Yoshiko Ishizuka-Katsura; Noboru Ohsawa; Takaho Terada; Mikako Shirouzu; Shigeyuki Yokoyama; So Iwata; Takeshi Murata

  PLOS ONE, Feb. 2013, Peer-reviewed

  
• Rotation mechanism of Enterococcus hirae V-1-ATPase based on asymmetric crystal structures

  Satoshi Arai; Shinya Saijo; Kano Suzuki; Kenji Mizutani; Yoshimi Kakinuma; Yoshiko Ishizuka-Katsura; Noboru Ohsawa; Takaho Terada; Mikako Shirouzu; Shigeyuki Yokoyama; So Iwata; Ichiro Yamato; Takeshi Murata

  NATURE, Jan. 2013, Peer-reviewed

  
• Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography

  J. Foadi; P. Aller; Y. Alguel; A. Cameron; D. Axford; R.L. Owen; W. Armour; D.G. Waterman; S. Iwata; G. Evans

  Acta Crystallographica Section D: Biological Crystallography, 2013, Peer-reviewed

  
• Mutant LV476-7 AA of A-subunit of Enterococcus hirae V-1-ATPase: High affinity of A(3)B(3) complex to DF axis and low ATPase activity

  Md Jahangir Alam; Ichiro Yamato; Satoshi Arai; Shinya Saijo; Kenji Mizutani; Yoshiko Ishizuka-Katsura; Noboru Ohsawa; Takaho Terada; Mikako Shirouzu; Shigeyuki Yokoyama; So Iwata; Yoshimi Kakinuma; Takeshi Murata

  SPRINGERPLUS, 2013, Peer-reviewed

  
• The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates

  Momi Iwata; Yang Lee; Tetsuo Yamashita; Takao Yagi; So Iwata; Alexander D. Cameron; Megan J. Maher

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2012, Peer-reviewed

  
• Alternating access mechanism in the POT family of oligopeptide transporters

  Nicolae Solcan; Jane Kwok; Philip W. Fowler; Alexander D. Cameron; David Drew; So Iwata; Simon Newstead

  EMBO JOURNAL, Aug. 2012, Peer-reviewed

  
• The crystal structure of an intermediate dimer of aspergilloglutamic peptidase that mimics the enzyme-activation product complex produced upon autoproteolysis

  Hiroshi Sasaki; Keiko Kubota; Woo C. Lee; Jun Ohtsuka; Masaki Kojima; So Iwata; Atsushi Nakagawa; Kenji Takahashi; Masaru Tanokura

  JOURNAL OF BIOCHEMISTRY, Jul. 2012, Peer-reviewed

  
• Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae

  Mitsunori Shiroishi; Hirokazu Tsujimoto; Hisayoshi Makyio; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Takeshi Murata; Norimichi Nomura; Tatsuya Haga; So Iwata; Takuya Kobayashi

  MICROBIAL CELL FACTORIES, Jun. 2012, Peer-reviewed

  
• G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

  Tomoya Hino; Takatoshi Arakawa; Hiroko Iwanari; Takami Yurugi-Kobayashi; Chiyo Ikeda-Suno; Yoshiko Nakada-Nakura; Osamu Kusano-Arai; Simone Weyand; Tatsuro Shimamura; Norimichi Nomura; Alexander D. Cameron; Takuya Kobayashi; Takao Hamakubo; So Iwata; Takeshi Murata

  NATURE, Feb. 2012, Peer-reviewed

  
• [Structural biology and molecular targets].

  T. Shimamura; S. Iwata

  Nihon rinsho. Japanese journal of clinical medicine, 2012, Peer-reviewed

  
• Crystal structure of the central axis DF complex of the prokaryotic V-ATPase

  Shinya Saijo; Satoshi Arai; K. M. Mozaffor Hossain; Ichiro Yamato; Kano Suzuki; Yoshimi Kakinuma; Yoshiko Ishizuka-Katsura; Noboru Ohsawa; Takaho Terada; Mikako Shirouzu; Shigeyuki Yokoyama; So Iwata; Takeshi Murata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2011, Peer-reviewed

  
• Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H-1 Receptor

  Chris de Graaf; Albert J. Kooistra; Henry F. Vischer; Vsevolod Katritch; Martien Kuijer; Mitsunori Shiroishi; So Iwata; Tatsuro Shimamura; Raymond C. Stevens; Iwan J. P. de Esch; Rob Leurs

  JOURNAL OF MEDICINAL CHEMISTRY, Dec. 2011, Peer-reviewed

  
• Production of the stable human histamine H-1 receptor in Pichia pastoris for structural determination

  Mitsunori Shiroishi; Takuya Kobayashi; Satoshi Ogasawara; Hirokazu Tsujimoto; Chiyo Ikeda-Suno; So Iwata; Tatsuro Shimamura

  METHODS, Dec. 2011, Peer-reviewed

  
• Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT

  Nien-Jen Hu; So Iwata; Alexander D. Cameron; David Drew

  NATURE, Oct. 2011, Peer-reviewed

  
• Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium

  Natsuko Tokuda; Kiyohiko Igarashi; Tatsuro Shimamura; Takami Yurugi-Kobayashi; Mitsunori Shiroishi; Keisuke Ito; Taishi Sugawara; Hidetsugu Asada; Takeshi Murata; Norimichi Nomura; So Iwata; Takuya Kobayashi

  PROTEIN EXPRESSION AND PURIFICATION, Sep. 2011, Peer-reviewed

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• Structure of the rotor ring modified with N,N '-dicyclohexylcarbodiimide of the Na+-transporting vacuolar ATPase

  Kenji Mizutani; Misaki Yamamoto; Kano Suzuki; Ichiro Yamato; Yoshimi Kakinuma; Mikako Shirouzu; John E. Walker; Shigeyuki Yokoyama; So Iwata; Takeshi Murata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2011, Peer-reviewed

  
• Expression, purification and characterization of isoforms of peripheral stalk subunits of human V-ATPase

  Suhaila Rahman; Yoshiko Ishizuka-Katsura; Satoshi Arai; Shinya Saijo; Ichiro Yamato; Mitsutoshi Toyama; Noboru Ohsawa; Mio Inoue; Keiko Honda; Takaho Terada; Mikako Shirouzu; Shigeyuki Yokoyama; So Iwata; Takeshi Murata

  PROTEIN EXPRESSION AND PURIFICATION, Aug. 2011, Peer-reviewed

  
• Structure of the human histamine H-1 receptor complex with doxepin

  Tatsuro Shimamura; Mitsunori Shiroishi; Simone Weyand; Hirokazu Tsujimoto; Graeme Winter; Vsevolod Katritch; Ruben Abagyan; Vadim Cherezov; Wei Liu; Gye Won Han; Takuya Kobayashi; Raymond C. Stevens; So Iwata

  NATURE, Jul. 2011, Peer-reviewed

  
• High-throughput construction of expression system using yeast Pichia pastoris, and its application to membrane proteins

  Kimihiko Mizutani; Soshi Yoshioka; Yukiko Mizutani; So Iwata; Bunzo Mikami

  PROTEIN EXPRESSION AND PURIFICATION, May 2011, Peer-reviewed

  
• Perturbation of the Quinone-binding Site of Complex II Alters the Electronic Properties of the Proximal [3Fe-4S] Iron-Sulfur Cluster

  Jonathan Ruprecht; So Iwata; Richard A. Rothery; Joel H. Weiner; Elena Maklashina; Gary Cecchini

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2011, Peer-reviewed

  
• Structure and mechanism of the chalcogen-detoxifying protein TehB from Escherichia coli

  Hassanul G. Choudhury; Alexander D. Cameron; So Iwata; Konstantinos Beis

  BIOCHEMICAL JOURNAL, Apr. 2011, Peer-reviewed

  
• Overcoming barriers to membrane protein structure determination

  Roslyn M. Bill; Peter J. F. Henderson; So Iwata; Edmund R. S. Kunji; Hartmut Michel; Richard Neutze; Simon Newstead; Bert Poolman; Christopher G. Tate; Horst Vogel

  NATURE BIOTECHNOLOGY, Apr. 2011, Peer-reviewed

  
• Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis

  Hidetsugu Asada; Tomoko Uemura; Takami Yurugi-Kobayashi; Mitsunori Shiroishi; Tatsuro Shimamura; Hirokazu Tsujimoto; Keisuke Ito; Taishi Sugawara; Takanori Nakane; Norimichi Nomura; Takeshi Murata; Tatsuya Haga; So Iwata; Takuya Kobayashi

  MICROBIAL CELL FACTORIES, Apr. 2011, Peer-reviewed

  
• Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans

  Keisuke Ito; Sohei Ito; Tatsuro Shimamura; Simone Weyand; Yasuaki Kawarasaki; Takumi Misaka; Keiko Abe; Takuya Kobayashi; Alexander D. Cameron; So Iwata

  JOURNAL OF MOLECULAR BIOLOGY, Apr. 2011, Peer-reviewed

  
• The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1

  Simone Weyand; Tatsuro Shimamura; Oliver Beckstein; Mark S. P. Sansom; So Iwata; Peter J. F. Henderson; Alexander D. Cameron

  JOURNAL OF SYNCHROTRON RADIATION, Jan. 2011, Peer-reviewed

  
• Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein

  Keisuke Ito; Taishi Sugawara; Ayako Koizumi; Ken-ichiro Nakajima; Akiko Shimizu-Ibuka; Mitsunori Shiroishi; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Tomiko Asakura; Takumi Misaka; So Iwata; Takuya Kobayashi; Keiko Abe

  BIOTECHNOLOGY LETTERS, Jan. 2011, Peer-reviewed

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• Benchmarking Membrane Protein Detergent Stability for Improving Throughput of High-Resolution X-ray Structures

  Yo Sonoda; Simon Newstead; Nien-Jen Hu; Yilmaz Alguel; Emmanuel Nji; Konstantinos Beis; Shoko Yashiro; Chiara Lee; James Leung; Alexander D. Cameron; Bernadette Byrne; So Iwata; David Drew

  STRUCTURE, Jan. 2011, Peer-reviewed

  
• Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2

  Simon Newstead; David Drew; Alexander D. Cameron; Vincent L. G. Postis; Xiaobing Xia; Philip W. Fowler; Jean C. Ingram; Elisabeth P. Carpenter; Mark S. P. Sansom; Michael J. McPherson; Stephen A. Baldwin; So Iwata

  EMBO JOURNAL, Jan. 2011, Peer-reviewed

  
• Structural Basis of Biological N2O Generation by Bacterial Nitric Oxide Reductase

  Tomoya Hino; Yushi Matsumoto; Shingo Nagano; Hiroshi Sugimoto; Yoshihiro Fukumori; Takeshi Murata; So Iwata; Yoshitsugu Shiro

  SCIENCE, Dec. 2010, Peer-reviewed

  
• A purified C-terminally truncated human adenosine A(2A) receptor construct is functionally stable and degradation resistant

  Shweta Singh; Diana Hedley; Elodie Kara; Adrien Gras; So Iwata; Jonathan Ruprecht; Philip G. Strange; Bernadette Byrne

  PROTEIN EXPRESSION AND PURIFICATION, Nov. 2010, Peer-reviewed

  
• Crystallization of small proteins assisted by green fluorescent protein

  Nobuhiro Suzuki; Masahiko Hiraki; Yusuke Yamada; Naohiro Matsugaki; Noriyuki Igarashi; Ryuichi Kato; Ivan Dikic; David Drew; So Iwata; Soichi Wakatsuki; Masato Kawasaki

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Oct. 2010, Peer-reviewed

  
• Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin

  Keisuke Ito; Taishi Sugawara; Ayako Koizumi; Ken-ichiro Nakajima; Akiko Shimizu-Ibuka; Mitsunori Shiroishi; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Tomiko Asakura; Katsuyoshi Masuda; Masaji Ishiguro; Takumi Misaka; So Iwata; Takuya Kobayashi; Keiko Abe

  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Sep. 2010, Peer-reviewed

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• Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans

  Keisuke Ito; Sohei Ito; Tatsuro Shimamura; Yasuaki Kawarasaki; Keiko Abe; Takumi Misaka; Takuya Kobayashi; So Iwata

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Sep. 2010, Peer-reviewed

  
• Old Gate Gets a New Look

  Simone Weyand; So Iwata

  SCIENCE, Jul. 2010, Peer-reviewed

  
• Tricks of the trade used to accelerate high-resolution structure determination of membrane proteins

  Yo Sonoda; Alex Cameron; Simon Newstead; Hiroshi Omote; Yoshinori Moriyama; Michihiro Kasahara; So Iwata; David Drew

  FEBS LETTERS, Jun. 2010, Peer-reviewed

  
• Structure of the aliphatic sulfonate-binding protein SsuA from Escherichia coli

  John Beale; Sang Yun Lee; So Iwata; Konstantinos Beis

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Apr. 2010, Peer-reviewed

  
• Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1

  Tatsuro Shimamura; Simone Weyand; Oliver Beckstein; Nicholas G. Rutherford; Jonathan M. Hadden; David Sharples; Mark S. P. Sansom; So Iwata; Peter J. F. Henderson; Alexander D. Cameron

  SCIENCE, Apr. 2010, Peer-reviewed

  
• Reconstitution in vitro of the catalytic portion (NtpA(3)-B-3-D-G complex) of Enterococcus hirae V-type Na+-ATPase

  Satoshi Arai; Ichiro Yamato; Asuka Shiokawa; Shinya Saijo; Yoshimi Kakinuma; Yoshiko Ishizuka-Katsura; Mitsutoshi Toyama; Takaho Terada; Mikako Shirouzu; Shigeyuki Yokoyama; So Iwata; Takeshi Murata

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2009, Peer-reviewed

  
• Crystal structure of A(3)B(3) complex of V-ATPase from Thermus thermophilus

  Megan J. Maher; Satoru Akimoto; Momi Iwata; Koji Nagata; Yoshiko Hori; Masasuke Yoshida; Shigeyuki Yokoyama; So Iwata; Ken Yokoyama

  EMBO JOURNAL, Dec. 2009, Peer-reviewed

  
• Structure of Escherichia coli Succinate: Quinone Oxidoreductase with an Occupied and Empty Quinone-binding Site

  Jonathan Ruprecht; Victoria Yankovskaya; Elena Maklashina; So Iwata; Gary Cecchini

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2009, Peer-reviewed

  
• Insights into How Nucleotide-Binding Domains Power ABC Transport

  Simon Newstead; Philip W. Fowler; Paul Bilton; Elisabeth P. Carpenter; Peter J. Sadler; Dominic J. Campopiano; Mark S. P. Sansom; So Iwata

  STRUCTURE, Sep. 2009, Peer-reviewed

  
• Crystal Structure of the Acid-Induced Arginine Decarboxylase from Escherichia coli: Reversible Decamer Assembly Controls Enzyme Activity

  Juni Andrell; Matthew G. Hicks; Tracy Palmer; Elisabeth P. Carpenter; So Iwata; Megan J. Maher

  BIOCHEMISTRY, May 2009, Peer-reviewed

  
• Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae

  Taishi Sugawara; Keisuke Ito; Mitsunori Shiroishi; Natsuko Tokuda; Hidetsugu Asada; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Takumi Misaka; Norimichi Nomura; Takeshi Murata; Keiko Abe; So Iwata; Takuya Kobayashi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2009, Peer-reviewed

  
• Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris

  Takami Yurugi-Kobayashi; Hidetsugu Asada; Mitsunori Shiroishi; Tatsuro Shimamura; Saeko Funamoto; Naoko Katsuta; Keisuke Ito; Taishi Sugawara; Natsuko Tokuda; Hirokazu Tsujimoto; Takeshi Murata; Norimichi Nomura; Kazuko Haga; Tatsuya Haga; So Iwata; Takuya Kobayashi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2009, Peer-reviewed

  
• [Structural studies on G protein-coupled receptors].

  S. Iwata; M. Iwata

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2009, Peer-reviewed

  
• Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens

  Tatsuro Shimamura; Shunsuke Yajima; Shun'ichi Suzuki; Nicholas G. Rutherford; John O'Reilly; Peter J. F. Henderson; So Iwata

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Dec. 2008, Peer-reviewed

  
• Overcoming the challenges of membrane protein crystallography

  Elisabeth P. Carpenter; Konstantinos Beis; Alexander D. Cameron; So Iwata

  CURRENT OPINION IN STRUCTURAL BIOLOGY, Oct. 2008, Peer-reviewed

  
• Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter

  Simone Weyand; Tatsuro Shimamura; Shunsuke Yajima; Shun'ichi Suzuki; Osman Mirza; Kuakarun Krusong; Elisabeth P. Carpenter; Nicholas G. Rutherford; Jonathan M. Hadden; John O'Reilly; Pikyee Ma; Massoud Saidijam; Simon G. Patching; Ryan J. Hope; Halina T. Norbertczak; Peter C. J. Roach; So Iwata; Peter J. F. Henderson; Alexander D. Cameron

  SCIENCE, Oct. 2008, Peer-reviewed

  
• Molecular mechanism of energy conservation in polysulfide respiration

  Mika Jormakka; Ken Yokoyama; Takahiro Yano; Masatada Tamakoshi; Satoru Akimoto; Tatsuro Shimamura; Paul Curmi; So Iwata

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Jul. 2008, Peer-reviewed

  
• Interaction and stoichiometry of the peripheral stalk subunits NtpE and NtpF and the N-terminal hydrophilic domain of NtpI of Enterococcus hirae V-ATPase

  Misaki Yamamoto; Satoru Unzai; Shinya Saijo; Kazuki Ito; Kenji Mizutani; Chiyo Suno-Ikeda; Yukako Yabuki-Miyata; Takaho Terada; Mitsutoshi Toyama; Mikako Shirouzu; Takuya Kobayashi; Yoshimi Kakinuma; Ichiro Yamato; Shigeyuki Yokoyama; So Iwata; Takeshi Murata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2008, Peer-reviewed

  
• Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae

  Keisuke Ito; Taishi Sugawara; Mitsunori Shiroishi; Natsuko Tokuda; Azusa Kurokawa; Takumi Misaka; Hisayoshi Makyio; Takami Yurugi-Kobayashi; Tatsuro Shimamura; Norimichi Nomura; Takeshi Murata; Keiko Abe; So Iwata; Takuya Kobayashi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2008, Peer-reviewed

  
• Ion binding and selectivity of the rotor ring of the Na+-transporting V-ATPase

  Takeshi Murata; Ichiro Yamato; Yoshimi Kakinuma; Mikako Shirouzu; John E. Walker; Shigeyuki Yokoyama; So Iwata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2008, Peer-reviewed

  
• Thioredoxin A active-site mutants form mixed disulfide dimers that resemble enzyme-substrate reaction intermediates

  Thijs R. H. M. Kouwen; Jun Andrell; Rianne Schrijver; Jean-Yves F. Dubois; Megan J. Maher; So Iwata; Elisabeth P. Carpenter; Jan Maarten van Dijl

  JOURNAL OF MOLECULAR BIOLOGY, Jun. 2008, Peer-reviewed

  
• Rationalizing alpha-helical membrane protein crystallization

  Simon Newstead; Sebastien Ferrandon; So Iwata

  PROTEIN SCIENCE, Mar. 2008, Peer-reviewed

  
• GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae

  David Drew; Simon Newstead; Yo Sonoda; Hyun Kim; Gunnar von Heijne; So Iwata

  NATURE PROTOCOLS, 2008, Peer-reviewed

  
• Insights into outer membrane protein crystallization

  Simon Newstead; Jeanette Hobbs; Davina Jordan; Elisabeth P. Carpenter; So Iwata

  MOLECULAR MEMBRANE BIOLOGY, 2008, Peer-reviewed

  
• The structure of the efflux pump AcrB in complex with bile acid

  David Drew; Mirjam M. Klepsch; Simon Newstead; Ralf Flaig; Jan-Willem De Gier; So Iwata; Konstantinos Beis

  MOLECULAR MEMBRANE BIOLOGY, 2008, Peer-reviewed

  
• Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains

  Mikio Tanabe; Osman Mirza; Thomas Bertrand; Helen S. Atkins; Richard W. Titball; So Iwata; Katherine A. Brown; Bernadette Byrne

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Nov. 2007, Peer-reviewed

  
• Structural determination of wild-type lactose permease

  Lan Guan; Osman Mirza; Gillian Verner; So Iwata; H. Ronald Kaback

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2007, Peer-reviewed

  
• High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae

  Simon Newstead; Hyun Kim; Gunnar von Heijne; So Iwata; David Drew

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2007, Peer-reviewed

  
• Crystal structure of neoculin: Insights into its sweetness and taste-modifying activity

  A Shimizu-Ibuka; Y Morita; T Terada; T Asakura; K Nakajima; S Iwata; T Misaka; H Sorimachi; S Arai; K Abe

  JOURNAL OF MOLECULAR BIOLOGY, May 2006, Peer-reviewed

  
• Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY

  O Mirza; L Guan; G Verner; S Iwata; HR Kaback

  EMBO JOURNAL, Mar. 2006, Peer-reviewed

  
• Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase) - A mechanism of electron transfer and proton conduction during ubiquinone reduction

  R Horsefield; Yankovskaya, V; G Sexton; W Whittingham; K Shiomi; S Omura; B Byrne; G Cecchini; S Iwata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2006, Peer-reviewed

  
• Erratum: Structural evidence for induced fit and a mechanism for sugar/H⁺ symport in LacY (The EMBO Journal (2006) 25 (6) (1177-1183) DOI: 10.1038/sj.emboj.7601028)

  O. Mirza; L. Guan; G. Verner; S. Iwata; H.R. Kaback

  EMBO Journal, 2006, Peer-reviewed

  
• Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus

  H Makyio; R Iino; C Ikeda; H Imamura; M Tamakoshi; M Iwata; D Stock; RA Bernal; EP Carpenter; M Yoshida; K Yokoyama; S Iwata

  EMBO JOURNAL, Nov. 2005, Peer-reviewed

  
• Membrane proteins: the last frontier of structural biology

  S. Iwata

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2005, Peer-reviewed

  
• Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily

  J Abramson; HR Kaback; S Iwata

  CURRENT OPINION IN STRUCTURAL BIOLOGY, Aug. 2004, Peer-reviewed

  
• Membranes - A new era in membrane protein studies - Editorial overview

  S Iwata; HR Kaback

  CURRENT OPINION IN STRUCTURAL BIOLOGY, Aug. 2004, Peer-reviewed

  
• Structure of photosystem II and molecular architecture of the oxygen-evolving centre

  S Iwata; J Barber

  CURRENT OPINION IN STRUCTURAL BIOLOGY, Aug. 2004, Peer-reviewed

  
• Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity

  T Shimamura; A Koike-Takeshita; K Yokoyama; R Masui; N Murai; M Yoshida; H Taguchi; S Iwata

  STRUCTURE, Aug. 2004, Peer-reviewed

  
• Lactose permease as a paradigm for membrane transport proteins - (Review)

  J Abramson; S Iwata; HR Kaback

  MOLECULAR MEMBRANE BIOLOGY, Jul. 2004, Peer-reviewed

  
• Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta(2) subunit of the Kv1 K+ channel from Rattus norvegicus

  T Shimamura; O Shamotienko; S Akhtar; JO Dolly; S Iwata

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, May 2004, Peer-reviewed

  
• Complex II from a structural perspective

  R Horsefield; S Iwata; B Byrne

  CURRENT PROTEIN & PEPTIDE SCIENCE, Apr. 2004, Peer-reviewed

  
• Architecture of the photosynthetic oxygen-evolving center

  KN Ferreira; TM Iverson; K Maghlaoui; J Barber; S Iwata

  SCIENCE, Mar. 2004, Peer-reviewed

  
• Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase

  M Iwata; H Imamura; E Stambouli; C Ikeda; M Tamakoshi; K Nagata; H Makyio; B Hankamer; J Barber; M Yoshida; K Yokoyama; S Iwata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2004, Peer-reviewed

  
• Architecture of NarGH reveals a structural classification of Mo-bisMGD enzymes

  M Jormakka; D Richardson; B Byrne; S Iwata

  STRUCTURE, Jan. 2004, Peer-reviewed

  
• Structural model of the oxygen-evolving centre of photosystem II with mechanistic implications

  J Barber; K Ferreira; K Maghlaoui; S Iwata

  PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2004, Peer-reviewed

  
• Structure and function of lactose permease from Escherichia coli

  S. Iwata

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2004, Peer-reviewed

  
• The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport

  J Abramson; Smirnova, I; Kasho, V; G Verner; S Iwata; HR Kaback

  FEBS LETTERS, Nov. 2003, Peer-reviewed

  
• Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8

  T Shimamura; A Koike-Takeshita; K Yokoyama; M Yoshida; H Taguchi; S Iwata

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Sep. 2003, Peer-reviewed

  
• Structure and mechanism of the lactose permease of Escherichia coli

  J Abramson; Smirnova, I; Kasho, V; G Verner; HR Kaback; S Iwata

  SCIENCE, Aug. 2003, Peer-reviewed

  
• Formate dehydrogenase - a versatile enzyme in changing environments

  M Jormakka; B Byrne; S Iwata

  CURRENT OPINION IN STRUCTURAL BIOLOGY, Aug. 2003, Peer-reviewed

  
• Protonmotive force generation by a redox loop mechanism

  M Jormakka; B Byrne; S Iwata

  FEBS LETTERS, Jun. 2003, Peer-reviewed

  
• Variation in proton donor/acceptor pathways in succinate : quinone oxidoreductases

  G Cecchini; E Maklashina; Yankovskaya, V; TM Iverson; S Iwata

  FEBS LETTERS, Jun. 2003, Peer-reviewed

  
• Using rational screening and electron microscopy to optimize the crystallization of succinate : ubiquinone oxidoreductase from Escherichia coli

  R Horsefield; Yankovskaya, V; S Tornroth; C Luna-Chavez; E Stambouli; J Barber; B Byrne; G Cecchini; S Iwata

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Mar. 2003, Peer-reviewed

  
• Structure and function of quinone binding membrane proteins

  M Iwata; J Abramson; B Byrne; S Iwata

  MEMBRANE PROTEINS, 2003, Peer-reviewed

  
• Architecture of succinate dehydrogenase and reactive oxygen species generation

  Yankovskaya, V; R Horsefield; S Tornroth; C Luna-Chavez; H Miyoshi; C Leger; B Byrne; G Cecchini; S Iwata

  SCIENCE, Jan. 2003, Peer-reviewed

  
• Golden mean to longevity: Rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease

  M Tanaka; N Fuku; T Takeyasu; LJ Guo; R Hirose; M Kurata; HJW Borgeld; Y Yamada; W Maruyama; Y Arai; N Hirose; Y Oshida; Y Sato; N Hattori; Y Mizuno; S Iwata; K Yagi

  JOURNAL OF NEUROSCIENCE RESEARCH, Nov. 2002, Peer-reviewed

  
• The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides

  M Svensson-Ek; J Abramson; G Larsson; S Tornroth; P Brzezinski; S Iwata

  JOURNAL OF MOLECULAR BIOLOGY, Aug. 2002, Peer-reviewed

  
• Membrane protein complexes

  B Byrne; S Iwata

  CURRENT OPINION IN STRUCTURAL BIOLOGY, Apr. 2002, Peer-reviewed

  
• Molecular basis of proton motive force generation: Structure of formate dehydrogenase-N

  M Jormakka; S Tornroth; B Byrne; S Iwata

  SCIENCE, Mar. 2002, Peer-reviewed

  
• Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli

  M Jormakka; S Tornroth; J Abramson; B Byrne; S Iwata

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Jan. 2002, Peer-reviewed

  
• Purification, crystallisation and preliminary crystallographic studies of succinate : ubiquinone oxidoreductase from Escherichia coli

  S Tornroth; Yankovskaya, V; G Cecchini; S Iwata

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jan. 2002, Peer-reviewed

  
• Structures of F420H2 : NADP(+) oxidoreductase with and without its substrates bound

  E Warkentin; B Mamat; M Sordel-Klippert; M Wicke; RK Thauer; M Iwata; S Iwata; U Ermler; S Shima

  EMBO JOURNAL, Dec. 2001, Peer-reviewed

  
• Structure of cytochrome c oxidase: a comparison of the bacterial and mitochondrial enzymes

  J Abramson; M Svensson-Ek; B Byrne; S Iwata

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, Jan. 2001, Peer-reviewed

  
• The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site

  J Abramson; S Riistama; G Larsson; A Jasaitis; M Svensson-Ek; L Laakkonen; A Puustinen; S Iwata; M Wikstrom

  NATURE STRUCTURAL BIOLOGY, Oct. 2000, Peer-reviewed

  
• A missense mutation in the mitochondrial cytochrome b gene in a revisited case with histiocytoid cardiomyopathy

  AL Andreu; N Checcarelli; S Iwata; S Shanske; S DiMauro

  PEDIATRIC RESEARCH, Sep. 2000, Peer-reviewed

  
• Purification, crystallization and preliminary crystallographic studies of an integral membrane protein, cytochrome bo(3) ubiquinol oxidase from Escherichia coli

  J Abramson; G Larsson; B Byrne; A Puustinen; A Garcia-Horsman; S Iwata

  ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, Aug. 2000, Peer-reviewed

  
• Fusion protein approach to improve the crystal quality of cytochrome bo(3) ubiquinol oxidase from Escherichia coli

  B Byrne; J Abramson; M Jansson; E Holmgren; S Iwata

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Aug. 2000, Peer-reviewed

  
• Affinity partitioning of a poly(histidine)-tagged integral membrane protein, cytochrome bo(3) ubiquinol oxidase, in a detergent-polymer aqueous two-phase system containing metal-chelating polymer

  U Sivars; J Abramson; S Iwata; F Tjerneld

  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, Jun. 2000, Peer-reviewed

  
• Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA

  AL Andreu; MG Hanna; H Reichmann; C Bruno; AS Penn; K Tanji; F Pallotti; S Iwata; E Bonilla; B Lach; J Morgan-Hughes; S DiMauro

  NEW ENGLAND JOURNAL OF MEDICINE, Sep. 1999, Peer-reviewed

  
• Conformational change of the Rieske [2Fe-2S] protein in cytochrome bc(1) complex

  M Iwata; J Bjorkman; S Iwata

  JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, Jun. 1999, Peer-reviewed

  
• Structure of cytochrome bc1 complex from bovine heart mitochondria

  M. Iwata; K. Okada; S. Iwata

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1999, Peer-reviewed

  
• Complete structure of the 11-subunit bovine mitochondrial cytochrome bc(1) complex

  S Iwata; JW Lee; K Okada; JK Lee; M Iwata; B Rasmussen; TA Link; S Ramaswamy; BK Jap

  SCIENCE, Jul. 1998, Peer-reviewed

  
• Structure and function of bacterial cytochrome c oxidase

  S Iwata

  JOURNAL OF BIOCHEMISTRY, Mar. 1998, Peer-reviewed

  
• The structure of cytochrome C oxidase from paracoccus denitrifican.t and possible mechanism of action

  H. Michel; Ch. Oslermeier; S. Iwata; A. Harrenga

  FASEB Journal, 1997, Peer-reviewed

  
• Allosteric activation of L-lactate dehydrogenase analyzed by hybrid enzymes with effector-sensitive and -insensitive subunits

  S Fushinobu; K Kamata; S Iwata; H Sakai; T Ohta; H Matsuzawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1996, Peer-reviewed

  
• Cytochrome c oxidase

  C Ostermeier; S Iwata; H Michel

  CURRENT OPINION IN STRUCTURAL BIOLOGY, Aug. 1996, Peer-reviewed

  
• Functional implications of the structure of the 'Rieske' iron-sulfur protein of bovine heart mitochondrial cytochrome bc(1) complex

  TA Link; S Iwata

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jul. 1996, Peer-reviewed

  
• Channelling of dioxygen into the respiratory enzyme

  S Riistama; A Puustinen; A GarciaHorsman; S Iwata; H Michel; M Wikstrom

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Jul. 1996, Peer-reviewed

  
• Structure of a water soluble fragment of the 'Rieske' iron sulfur protein of the bovine heart mitochondrial cytochrome bc(1) complex determined by MAD phasing at 1.5 angstrom resolution

  S Iwata; M Saynovits; TA Link; H Michel

  STRUCTURE, May 1996, Peer-reviewed

  
• Isolation, characterisation and crystallisation of a water-soluble fragment of the Rieske iron-sulfur protein of bovine heart mitochondrial bc(1) complex

  TA Link; M Saynovits; C Assmann; S Iwata; T Ohnishi; G vonJagow

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Apr. 1996, Peer-reviewed

  
• Structure of cytochrome c oxidase from Paracoccus denitrificans at 2.8A resolution

  S. Iwata

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1996, Peer-reviewed

  
• F-V FRAGMENT MEDIATED CRYSTALLIZATION OF THE MEMBRANE-PROTEIN BACTERIAL CYTOCHROME-C-OXIDASE

  C OSTERMEIER; S IWATA; B LUDWIG; H MICHEL

  NATURE STRUCTURAL BIOLOGY, Oct. 1995, Peer-reviewed

  
• ELECTRON-TRANSFER FROM THE TETRAHEME CYTOCHROME TO THE SPECIAL PAIR IN THE RHODOPSEUDOMONAS-VIRIDIS REACTION-CENTER - EFFECT OF MUTATIONS OF TYROSINE L162

  B DOHSE; P MATHIS; J WACHTVEITL; E LAUSSERMAIR; S IWATA; H MICHEL; D OESTERHELT

  BIOCHEMISTRY, Sep. 1995, Peer-reviewed

  
• STRUCTURE AT 2.8-ANGSTROM RESOLUTION OF CYTOCHROME-C-OXIDASE FROM PARACOCCUS-DENITRIFICANS

  S IWATA; C OSTERMEIER; B LUDWIG; H MICHEL

  NATURE, Aug. 1995, Peer-reviewed

  
• IMMUNOELECTRON MICROSCOPY AND EPITOPE MAPPING WITH MONOCLONAL-ANTIBODIES SUGGEST THE EXISTENCE OF AN ADDITIONAL N-TERMINAL TRANSMEMBRANE HELIX IN THE CYTOCHROME-B SUBUNIT OF BACTERIAL UBIQUINOL-CYTOCHROME-C OXIDOREDUCTASES

  G KLEYMANN; S IWATA; KH WIESMULLER; B LUDWIG; W HAASE; H MICHEL

  EUROPEAN JOURNAL OF BIOCHEMISTRY, May 1995, Peer-reviewed

  
• X-ray crystallographic study of a non-pepsin-type acid proteinase, Aspergillus niger proteinase A

  H. Sasaki; M. Tanokura; T. Muramatsu; T. Nakagawa; S. Iwata; T. Hamaya; T. Takizawa; T. Kono; K. Takahashi

  Advances in Experimental Medicine and Biology, 1995, Peer-reviewed

  
• T-STATE AND R-STATE IN THE CRYSTALS OF BACTERIAL L-LACTATE DEHYDROGENASE REVEAL THE MECHANISM FOR ALLOSTERIC CONTROL

  S IWATA; K KAMATA; S YOSHIDA; T MINOWA; T OHTA

  NATURE STRUCTURAL BIOLOGY, Mar. 1994, Peer-reviewed

  
• A regular 1:1 complex of two allosteric states in the single crystal of L-lactate dehydrogenase from Bifidobacterium longum

  S. Iwata; S. Yoshida; T. Ohta

  Journal of Molecular Biology, 1994, Peer-reviewed

  
• MOLECULAR-BASIS OF ALLOSTERIC ACTIVATION OF BACTERIAL L-LACTATE DEHYDROGENASE

  S IWATA; T OHTA

  JOURNAL OF MOLECULAR BIOLOGY, Mar. 1993, Peer-reviewed

  
• CRYSTALLIZATION AND PRELIMINARY-X-RAY INVESTIGATION OF PROTEINASE-A, A NON-PEPSIN-TYPE ACID PROTEINASE FROM ASPERGILLUS-NIGER VAR MACROSPORUS

  M TANOKURA; H MATSUZAKI; S IWATA; A NAKAGAWA; T HAMAYA; T TAKIZAWA; K TAKAHASHI

  JOURNAL OF MOLECULAR BIOLOGY, Jan. 1992, Peer-reviewed

  
• MECHANISM OF ALLOSTERIC TRANSITION OF BACTERIAL L-LACTATE DEHYDROGENASE

  T OHTA; K YOKOTA; T MINOWA; S IWATA

  FARADAY DISCUSSIONS, 1992, Peer-reviewed

  
• CRYSTALLIZATION OF ALLOSTERIC L-LACTATE DEHYDROGENASE FROM THERMUS-CALDOPHILUS AND PRELIMINARY CRYSTALLOGRAPHIC DATA

  S KOIDE; S IWATA; H MATSUZAWA; T OHTA

  JOURNAL OF BIOCHEMISTRY, Jan. 1991, Peer-reviewed

  

Misc.

• Structural insights into ghrelin receptor

  椎村祐樹; 椎村祐樹; IM Dohyun; 浅田秀基; 松井一真; 岩田想; 児島将康

  日本薬学会年会要旨集(Web), 2024

  
• ヒトアセチルコリン受容体M2Rの活性化を制御するホットスポット残基の特定

  杉浦勇也; 生田達也; 住井裕司; 寿野良二; 岩田想; 柴田哲男; 井上飛鳥; 井上飛鳥; 小林拓也; 神取秀樹; 神取秀樹; 片山耕大; 片山耕大

  GPCR研究会プログラム・抄録集, 2024

  
• Structural analysis of the hepatitis B virus entry receptor NTCP

  浅見仁太; 木村香菜子; 藤田陽子; 藤田陽子; 藤田陽子; 石田英子; ZHANG Zhikuan; 野村弥生; LIU Kehong; 植村智子; 佐藤有美; 小野真嗣; 山本雅貴; 野田岳志; 野田岳志; 野田岳志; 重松秀樹; DREW David; 岩田想; 岩田想; 清水敏之; 野村紀通; 大戸梅治

  日本薬学会年会要旨集(Web), 2022

  
• 胆汁酸トランスポーターNTCPを介したB型肝炎ウイルスの侵入に関する構造的洞察

  木村香菜子; 浅見仁太; 藤田陽子; 石田英子; 張志寛; 野村弥生; 劉紅; 植村智子; 佐藤有美; 小野真嗣; 山本雅貴; 野田岳志; 重松秀樹; DREW David; 岩田想; 清水敏之; 野村紀通; 大戸梅治

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2022

  
• Structural basis for recognition of hepatitis B virus by the bile acid transporter NTCP

  浅見仁太; PARK Jae-Hyun; 野村弥生; 石本直偉士; 小林ちさ; 御舩淳紀; 植村智子; LIU Kehong; 佐藤有美; 村松正道; 脇田隆字; DREW David; 渡士幸一; 渡士幸一; 岩田想; 岩田想; 清水敏之; PARK Sam-Yong; 野村紀通; 大戸梅治

  日本薬学会年会要旨集(Web), 2023

  
• Spermidine directly activates fatty acid oxidation and rejuvenizes anti-tumor immunity in aged mice

  茶本健司; AL-HABSI Muna; AL-HABSI Muna; 松本健; 野村紀道; WU Yibo; ZHANG Baihao; 仲島由佳; 園村和弘; 園村和弘; MENZIES Rosemary; 杉浦悠毅; 野村弥生; 松田文彦; 岩田想; 小椋利彦; FAGARASAN Sidonia; FAGARASAN Sidonia; 本庶佑

  日本分子生物学会年会プログラム・要旨集(Web), Nov. 2021

  
• 膜蛋白質の分子機構と創薬 ヒト由来膜内在性タンパク質の構造解析と創薬への展開をめざして

  田辺 弘明; 藤井 佳史; 中村 祥浩; 森 慎滋; 篠田 雄大; 石塚 芳子; 新屋 直子; 奥田 賢一; 伊東 夏織; 田嶋; 堀 哲哉; 池田 眞理子; 脇山 素明; 寺田 貴帆; 大沢 登; 深田 吉孝; 星野 克明; 改正 恒康; 日野 智也; 小笠原 諭; 村田 武士; 岩田 想; 岡田 美紀; 部; 岩部 真人; 山内 敏正; 門脇 孝; 羽藤 正勝; 保坂 俊彰; 木村 友美; 谷; 白水 美香子; 横山 茂之

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• Strategy for the structure determination of G protein-coupled receptor

  Takuya Kobayashi; Mitsunori Shiroishi; Hidetsugu Asada; Takami Yurugi; Tatsuro Shimamura; So Iwata

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• 二液混合シリアルフェムト秒結晶構造解析による酵素反応追跡

  南後恵理子; 南後恵理子; LUO Fangjia; LUO Fangjia; 木村哲就; 菅原道泰; 中根崇智; 鈴木守; 桝田哲哉; 溝端栄一; 登野健介; 登野健介; 岩田想; 岩田想

  日本結晶学会年会講演要旨集, 2021

  
• 2Dp22 Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans

  Ito Keisuke; Ito Sohei; Iwata So; Kawarasaki Yasuaki

  日本生物工学会大会講演要旨集, 2011

  
• X線自由電子レーザーによる分子動画解析

  南後恵理子; 南後恵理子; 岩田想; 岩田想

  生体分子科学討論会講演要旨集, 2021

  
• X線自由電子レーザーによるチャネルロドプシンの時分割構造解析

  小田和正; 野村高志; 野村高志; 中根崇智; 中根崇智; 西澤知宏; 久保稔; 久保稔; 南後恵理子; 南後恵理子; 島村達郎; 石神一貴; 生田達也; 井爪珠希; 江熊龍雲; 岩田想; 岩田想; 濡木理

  日本細胞生物学会大会(Web), 2019

  
• X線自由電子レーザーによるチャネルロドプシンの時分割構造解析

  小田和正; 野村高志; 野村高志; 中根崇智; 西澤知宏; 久保稔; 久保稔; 南後恵理子; 南後恵理子; 島村達郎; 岩田想; 濡木理

  日本結晶学会年会講演要旨集, 2019

  
• 光修復酵素DNAフォトリアーゼのXFEL結晶構造解析

  別所義隆; 別所義隆; 山元淳平; 田中里枝; 田中里枝; 南後恵理子; 南後恵理子; 岩田想; 岩田想; TSAI Ming-Daw; ESSEN Lars-Oliver; MAESTRE-REYNA Manuel

  日本蛋白質科学会年会プログラム・要旨集, 2018

  
• Time Resolved Crystallography Using X-ray Free Electron Laser on Photoreactive Membrane Proteins

  岩田想; 岩田想; 南後恵理子

  生物物理(Web), 2018

  
• XFEL分子動画が捉えたタンパク質構造変化

  南後恵理子; 南後恵理子; 岩田想; 岩田想

  日本蛋白質科学会年会プログラム・要旨集, 2018

  
• X線自由電子レーザーで捉えたバクテリオロドプシンの構造変化過程

  田中智之; 田中智之; 南後恵理子; 南後恵理子; 岩田想; 岩田想

  日本結晶学会年会講演要旨集, 2018

  
• SACLA産学連携プログラム/産業利用推進プログラムを通じて

  高橋瑞稀; 南後恵理子; 国島直樹; 登野健介; 登野健介; 城地保昌; 城地保昌; 半沢宏之; 岩田想; 岩田想

  日本放射光学会年会・放射光科学合同シンポジウム(Web), 2018

  
• XFEL施設SACLAでの連続フェムト秒結晶構造解析における微結晶輸送媒体の利用

  菅原道泰; 菅原道泰; 南後恵理子; 南後恵理子; 田中智之; 田中智之; 山下鮎美; 山下鮎美; 有馬登志; 有馬登志; 田中里枝; 田中里枝; 沼田圭司; 岩田想; 岩田想

  日本結晶学会年会講演要旨集, 2017

  
• 酵素反応機構解明のためのX線自由電子レーザーを利用した時間分解結晶構造解析

  當舎武彦; 西田拓真; 西田拓真; 野村高志; 佐伯直哉; 佐伯直哉; 杉本宏; 山下恵太郎; 平田邦生; 吾郷日出夫; 山本雅貴; 中根崇智; 菅原道泰; 菅原道泰; 南後恵理子; 岩田想; 岩田想; 城宜嗣; 城宜嗣; 久保稔; 久保稔

  酸化反応討論会講演要旨集, 2017

  
• X線自由電子レーザーによるバクテリオロドプシン構造変化の分子動画

  南後恵理子; 南後恵理子; 岩田想; 岩田想

  日本蛋白質科学会年会プログラム・要旨集, 2017

  
• 微結晶輸送媒体を利用した連続フェムト秒結晶構造解析

  菅原道泰; 南後恵理子; 南後恵理子; 田中智之; 田中智之; 山本鮎美; 山本鮎美; 有馬登志; 有馬登志; 田中里枝; 田中里枝; 岩田想; 岩田想

  日本蛋白質科学会年会プログラム・要旨集, 2017

  
• X線自由電子レーザーを利用した時間分解X線結晶構造解析による酵素反応の観測

  當舎武彦; 西田拓真; 西田拓真; 野村高志; 佐伯直哉; 佐伯直哉; 杉本宏; 山下恵太郎; 平田邦生; 吾郷日出夫; 山本雅貴; 中根崇智; 菅原道泰; 菅原道泰; 南後恵理子; 岩田想; 岩田想; 城宜嗣; 城宜嗣; 久保稔; 久保稔; 久保稔

  生体分子科学討論会講演要旨集, 2017

  
• 時分割シリアルフェムト秒X線結晶構造解析によるバクテリオロドプシンの光反応中間体構造

  南後恵理子; 岩田想; 南後恵理子; 岩田想

  日本蛋白質科学会年会プログラム・要旨集, 2016

  
• SACLAにおけるシリアルフェムト秒X線結晶構造解析の技術開発

  田中智之; 菅原道泰; 中根崇智; 木村哲就; 木村哲就; 久保稔; 久保稔; 宮島謙; 宮島謙; 登野健介; 真船文隆; 真船文隆; 南後恵理子; 南後恵理子; 岩田想; 岩田想

  日本結晶学会年会講演要旨集, 2016

  
• 甘味タンパク質ソーマチンの連続フェムト秒結晶構造解析

  桝田哲哉; 桝田哲哉; 南後恵理子; 菅原道泰; 鈴木守; 鈴木守; 登野健介; 城地保昌; 亀島敬; PARK Jaehyun; SONG Changyong; 初井宇記; 矢橋牧名; 大久保喬平; 三上文三; 北畠直文; 北畠直文; 谷史人; 岩田想; 岩田想

  日本農芸化学会大会講演要旨集(Web), 2015

  
• 時分割シリアルフェムト秒X線結晶解析法によるバクテリオロドプシン光反応中間体の構造解析

  南後恵理子; NEUTZE Richard; 久保稔; 久保稔; 木村哲就; 中根崇智; ROYANT Antoine; 登野健介; 岩田想

  日本結晶学会年会講演要旨集, 2015

  
• XFEL連続フェムト秒結晶構造解析:構造生物学の新時代

  溝端栄一; 福田庸太; 鈴木守; 鈴木守; 南後恵理子; 菅原道泰; 矢橋牧名; 登野健介; 城地保昌; 島村達郎; PANG Dongqing; CHAVAS Leonard M.G.; 西澤知宏; 松村浩由; 林高史; 的場康幸; 杉山成; 村田道雄; 高木淳一; 井上豪; 岩田想

  日本蛋白質科学会年会プログラム・要旨集, 2014

  
• XFELを用いた創薬ターゲット蛋白質の迅速構造解析法の開発

  南後恵理子; 田中智之; 鈴木守; 鈴木守; 桝田哲哉; 桝田哲哉; 山下鮎美; 田中里枝; 登野健介; 城地保昌; 亀島敬; PARK Jaehyun; SONG Changyong; 初井宇記; 矢橋牧名; PAN Dongqing; 島村達郎; 溝端栄一; 北郷悠; 石谷隆一郎; 湯本史明; 岩田想; 岩田想

  日本蛋白質科学会年会プログラム・要旨集, 2014

  
• XFELを用いた迅速タンパク質構造解析システムの開発

  登野健介; 岩田想; 岩田想; 田中里枝; 南後恵理子; 鈴木守; 鈴木守; SONG Changyong; PARK Jaehyun; 亀島敬; 城地保昌; 初井宇記; 矢橋牧名

  日本放射光学会年会・放射光科学合同シンポジウム予稿集, 2014

  
• 自由電子レーザーを用いた膜蛋白質の系統的構造解析

  岩田想; 岩田想; 木村香菜子; 島村達郎; 南後恵理子; 田中智之; 西澤知宏; 濡木理; 田中里枝; 鈴木守; 鈴木守; 桝田哲哉; 桝田哲哉; 菅原道泰; 登野健介; 城地保昌; 亀島敬; SONG Changyong; 初井宇記; 矢橋牧名; 山下恵太郎; 保坂俊彰; 田辺弘明; 羽藤正勝; 有馬登志; 染谷友美; 白水美香子; 潘東青; 中津亨; 加藤博章; 溝端栄一; 北郷悠; 高木淳一; 山中保明; 藤原孝彰; 山下鮎美; 小林淳

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• The Ca²⁺-binding photoprotein aequorin stabilizes a peroxidized state

  船橋俊也; 南後恵理子; 南後恵理子; 岩田想; 岩田想; 加藤博章; 加藤博章; 中津亨; 中津亨

  日本薬学会年会要旨集(Web), 2021

  
• Intermediate structure and oxygen-evolving mechanism of photosystem II revealed by serial femtosecond crystallography

  Suga, M; Akita, F; Sugahara, M; Kubo, M; Iwata, S; Shen, J.‐R

  Journal of the Japanese Society for Synchrotron Radiation Research (in Japanese), 2017, Invited

  
• A three-dimensional movie of structural changes in bacteriorhodopsin captured by X-ray free electron lasers

  Nango, E; Kubo, M; Iwata, S

  Journal of the Japanese Society for Synchrotron Radiation Research (in Japanese), 2017, Invited

  
• ヒトプロスタグランジンE2受容体EP3-Gタンパク質複合体のクライオ電子顕微鏡単粒子解析

  寿野良二; 杉田征彦; 森本和志; 辻本浩一; 廣瀬未果; 寿野千代; 野村紀通; 岩崎憲二; 加藤貴之; 岩田想; 小林拓也

  日本蛋白質科学会年会プログラム・要旨集, 2021

  
• Microcrystal-carrier matrices for serial crystallography.

  M. Sugahara; T. Nakane; E. Nango; K. Tono; M. Yabashi; S. Iwata

  J. Biol. Macromol., 2018

  
• A molecular movie of structural changes in the light-driven proton pump bacteriorhodopsin

  E. Nango; S. Iwata

  SPring-8/SACLA Research Frontiers 2017, 2018

  
• Molecular movie of structural changes in bacteriorhodopsin

  南後 恵理子; 岩田 想

  医学のあゆみ, 29 Jul. 2017

  
• The multidrug-resistance transporter MdfA from Escherichia coli: crystallization and X-ray diffraction analysis

  Kumar Nagarathinam; Frank Jaenecke; Yoshiko Nakada-Nakura; Yunhon Hotta; Kehong Liu; So Iwata; Milton T. Stubbs; Norimichi Nomura; Mikio Tanabe

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Jul. 2017, Peer-reviewed

  Access this misc :

  
• Method of sample loading for serial femtosecond crystallography

  菅原 道泰; 登野 健介; 南後 恵理子; 岩田 想

  放射光 : 日本放射光学会誌 = Journal of the Japanese Society for Synchrotron Radiation Research, Jul. 2016

  

Presentations

• Proteins in action - 高速分子動画法

  岩田想

  新学術領域研究（研究領域提案型）「化学コミュニケーションのフロンティア」第8回公開シンポジウム（Online）, 02 Jul. 2021, Invited

  
• Making Molecular Movies

  岩田想

  3rd International Forum for Innovation in Next Generation Synchrotron Radiation, 01 Jul. 2021, Invited

  
• 抗体フラグメントを使った創薬ターゲット膜タンパク質の構造研究

  岩田想

  創薬懇話会2022（Online）, 24 Jun. 2021, Invited

  
• Making Molecular Movies

  岩田想

  第77回顕微鏡学会学術講演会（Online）, 14 Jun. 2021

  
• 高速分子動画法

  岩田想

  生化学会中部支部例会（Online）, 22 May 2021, Invited

  
• Beyond the molecular movies

  岩田想

  SACLA Users' Meeting(2021), 11 Mar. 2021, Invited

  
• Structural studies on G-protein coupled receptors using antibody fragments

  岩田想

  第93回日本生化学会大会（Web開催）, 14 Sep. 2020

  
• 膜タンパク質の細胞外ドメインを結合標的とする機能性ヒト抗体の高効率作製と構造デザイン

  岩田想

  令和元年度 創薬基盤推進研究事業 公開シンポジウム, 03 Feb. 2020

  
• 高速分子動画法

  岩田想

  第2回構造生命科学研究会, 21 Dec. 2019

  
• Making Molecular Movies

  岩田想

  RIKEN Europe Office Anniversary Symposium, 04 Dec. 2019, Invited

  
• 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援

  岩田想; 野村紀通

  BINDS公開シンポジウム2019, 19 Nov. 2019

  
• 膜タンパク質・抗体の高度生産技術を共役させた構造創薬研究

  岩田想

  第2回モダリティ創薬デザイン研究会シンポジウム, 12 Nov. 2019

  
• 「高速分子動画法」-自由電子レーザーを用いたX線結晶構造解析-

  岩田想

  2019年度iBIX-JAXA-KEK物構研-QST合同研究会, 30 Oct. 2019

  
• 実験科学の新展開を情報科学に生かすために

  岩田想

  CBI学会2019年大会, 22 Oct. 2019

  
• Making molecular movies

  岩田想

  6th International Symposium on Diffraction Structural Biology :ISDSB2019, 17 Oct. 2019, Invited

  
• 立体構造から紐解く抗ヒスタミン薬の作用

  岩田想

  フォーサム2019京都 参天製薬共催ランチョンセミナー, 05 Jul. 2019, Invited

  
• Molecular Movies of Proteins using SACLA: Current Status and Future

  岩田想

  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会 WS「タンパク質が機能する瞬間を捉える〜タンパク質ダイナミクス研究の新時代」, 25 Jun. 2019

  
• Proteins in Action

  岩田想

  The 24th Biophysics Conference, 29 May 2019, Invited

  
• Molecular movie of bacteriorhodopsin captured by a femtosecond x-ray laser

  So Iwata

  The 49th Natl Inst Physiol Sci (NIPS) International Symposium, 06 Dec. 2018

  
• 構造認識抗体の構造生物学と創薬に対する応用

  岩田 想

  第１回モダリティ創薬デザイン研究会シンポジウム, 26 Nov. 2018

  
• Membrane protein structures and Free Electron Laser

  So Iwata

  膜蛋白運輸與結構研究國際研討會, 25 Nov. 2018

  
• 自由電子レーザーSACLAを用いた分子動画撮影

  岩田 想

  日本学術会議薬学委員会化学・物理系薬学分科会と化学委員会結晶学分科会の合同のシンポジウム, 21 Nov. 2018

  
• Three-dimensional movie of chemical reactions in proteins captured by X-ray free electron

  So Iwata

  第56回日本生物物理学会年会, 16 Sep. 2018

  
• SACLA自由電子レーザーによる膜タンパク質の構造の分子動画撮影

  岩田 想

  第18回日本蛋白質科学会年会, 26 Jun. 2018

  
• GPCRの構造解析による機能の解明

  岩田 想

  第91回 日本内分泌学会学術総会, 26 Apr. 2018

  
• 抗ヒスタミン薬はどのようにして受容体の働きを抑えるのか

  岩田 想

  第122回日本眼科学会総会 参天製薬共催 モーニングセミナー, 22 Apr. 2018

  
• Membrane Protein Structural Biology: Protein Production and Functional Antibody Application

  So Iwata

  日本薬学会第138年会特別企画 AMED主催 創薬等ライフサイエンス研究支援基盤事業（BINDS）ワークショップ, 26 Mar. 2018

  
• SACLA自由電子レーザーによる膜タンパク質の構造の分子動画撮影

  岩田 想

  「物質階層の原理を探求する統合的実験研究」研究報告シンポジウム, 13 Feb. 2018

  
• SACLA自由電子レーザーによる膜タンパク質の構造の分子動画撮影

  岩田 想

  第31回日本放射光学会年会・放射光科学合同シンポジウム, 10 Jan. 2018

  
• 神経伝達物質受容体の構造と機能

  岩田 想

  「次世代脳」実行委員会企画シンポジウム「日本の神経科学～温故知新～」, 21 Dec. 2017

  
• 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援

  岩田 想

  BINDS報告会2017, 18 Dec. 2017

  
• Time-resolved Studies of Protein Structural Dynamics using X-ray Free Electron Laser

  So Iwata

  Consortium of Biological Sciences 2017, 06 Dec. 2017

  
• Membrane protein structures and Free Electron Laser

  So Iwata

  2017 International Symposium on Frontiers in Structural biology for drug development, 22 Nov. 2017

  
• 機能性抗体フラグメントをもちいたGPCR構造研究

  岩田 想

  第20回 創薬インフォマティクス研究会, 26 Sep. 2017

  
• Time-resolved x-ray crystallography at SACLA

  So Iwata

  第55回日本生物物理学会年会, 21 Sep. 2017

  
• ヒト膜タンパク質・抗体生産技術の連携による次世代型構造創薬研究の開拓

  岩田 想

  平成29年度 創薬等先端技術支援基盤プラットフォーム（BINDS）公開シンポジウム, 30 Aug. 2017

  
• Structural Dynamics of Membrane Proteins

  So Iwata

  Membrane protein structures and Free Electron Laser, 22 Aug. 2017

  
• Membrane protein structures and free electron laser

  So Iwata

  5th Asia Pacific Protein Association Conference 12th International Symposium of the Protein Society of Thailand, 13 Jul. 2017

  
• AMED創薬等ライフサイエンス研究支援基盤事業

  岩田 想

  次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援, 03 Jul. 2017

  
• 自由電子レーザーによるバクテリオロドプシンの構造変化の動き-光によって水素イオンを輸送する仕組みの解明

  岩田 想

  分子研研究会, 14 Jun. 2017

  
• 機能性抗体を用いたGPCRの構造研究

  岩田 想

  第9回シグナルネットワーク研究会, 09 Jun. 2017

  
• デスロラタジンのヒスタミンH1受容体に対する結合様式

  岩田 想

  第8回小文式研究会, 03 Jun. 2017

  
• Time-resolved studies of protein structural dynamics at SACLA

  So Iwata

  日本顕微鏡学会第73回学術講演会, 30 May 2017

  
• GPCRの構造解析による機能の解明

  岩田 想

  第91回 日本内分泌学会学術総会, 26 Apr. 2017

  
• 膜タンパク質構造生物学と機能性抗体

  So Iwata

  第71回染色体工学研究センターセミナー, 10 Feb. 2017

  
• Challenging proteins & molecular movie

  So Iwata

  International workshop on frontiers of XFEL science, 08 Dec. 2016

  
• SACLAを用いた膜タンパク質の構造ダイナミクス研究

  So Iwata

  The 39th Annual Meeting of the Molecular Biology Society of Japan, 02 Dec. 2016

  
• 自由電子レーザーSACLAを用いた構造生物学

  岩田 想

  情報計算化学生物学会2016大会, 27 Oct. 2016, Invited

  
• Membrane protein structures and free electron laser

  So Iwata

  第42回内藤カンファレンス, 05 Oct. 2016

  
• Structural studies on mammalian fructose transporters using antibody fragment

  So Iwata

  The 89th Annual Meeting of the Japnese Biochemical Society, 27 Sep. 2016

  
• 創薬ターゲット膜タンパク質のＸ線結晶構造解析

  岩田 想

  平成28年度日本農芸化学会, 09 Jul. 2016, Invited

  
• Membrane protein crystallography and drug discovery

  岩田 想

  R & D Day, 22 Jun. 2016, Invited

  
• GPCRの構造と機能

  岩田 想

  第13回GPCR研究会, 13 May 2016, Invited

  
• SACLAを用いたタンパク質結晶時間分割構造解析

  岩田 想

  大阪大学蛋白質研究所セミナー, 12 May 2016, Invited

  
• 膜タンパク質の構造解析と創薬

  岩田 想

  理研シンポジウム第3回創薬ワークショップ, 03 Mar. 2016, Invited

  
• New Frontier in Structural Biology: Free Electron Laser

  So Iwata

  2016 Senri Life Science International Symposium on Frontiers in Structural Biology・・・・X-ray Free Electron Laser and Drug Discovery, 22 Jan. 2016

  
• 膜タンパク質の構造生物学

  岩田 想

  酵素学ウィンタースクール（第六回酵素学講習会）, 18 Jan. 2016, Invited

  
• 創薬関連膜蛋白質の構造生物学と自由電子レーザーSACLAを用いた構造解析の現状

  岩田 想

  第6回神経科学と構造生物学の融合研究会, 26 Nov. 2015, Invited

  
• 膜タンパク質の構造解析技術：抗体を用いた結晶化と自由電子レーザーによるデータ測定

  岩田 想

  JST(CREST)構造生命科学, 21 Nov. 2015

  
• 膜タンパク質の構造解析とSACLAのインパクト

  岩田 想

  物構研談話会, 13 Nov. 2015, Invited

  
• Structural biology on membrane proteins and X-ray free electron laser

  So Iwata

  The second RIKEN CLST-Karolinska Institutet-SciLife Lab Joint Symposium -Structural Biology for Drug Discovery-, 12 Nov. 2015, Invited

  
• Crystallization of membrane proteins

  So Iwata

  Quality Protein Crystallization Technology, 26 Oct. 2015, Invited

  
• 自由電子レーザーSACLAを用いた膜蛋白質の構造解析

  岩田 想

  第54回玉城嘉十郎教授記念公開学術講演会, 20 Oct. 2015

  
• SACLAを用いたタンパク質構造の迅速・動的解析

  岩田 想

  日本結晶学会平成２７年度年会シンポジウム, 18 Oct. 2015, Invited

  
• Structures and functions of mammalian membrane transporters

  So Iwata

  Protein Structure, Function and Malfunction meeting, 07 May 2015

  
• Serial femtosecond crystallography at SACLA

  So Iwata

  Canadian Light Source Workshop, 04 May 2015

  
• ライフサイエンスにおける自由電子レーザーの可能性

  岩田 想

  日本医学会総会, 28 Mar. 2015

  
• ヒスタミンH1受容体の立体構造と抗ヒスタミン薬選択性の分子機構

  岩田 想

  花粉症全国講演会, 31 Jan. 2015

  
• 膜タンパク質の構造生物学とその創薬への応用

  岩田 想

  第43回日本免疫学会学術集会, 10 Dec. 2014

  
• SACLAにおけるタンパク質立体構造解析の現状

  岩田 想

  SPring-8/SACLAコンファレンス2014, 01 Dec. 2014

  
• 自由電子レーザーを用いた膜蛋白質の系統的構造解析

  So Iwata

  第37回日本分子生物学会年会シンポジウム, 25 Nov. 2014

  
• 膜タンパク質の構造生物学とその医学・創薬への応用

  岩田 想

  臨床検査学会, 24 Nov. 2014

  
• 加速する創薬ターゲット膜タンパク質構造解析

  岩田 想

  第41回例会野依フォーラム, 21 Nov. 2014

  
• Pipeline for mammalian membrane-protein structures

  So Iwata

  23rd Annual Buffalo-Hamilton-Toronto Symposium, 06 Nov. 2014

  
• Crystallization of membrane proteins using antibody fragments

  So Iwata

  第52回日本生物物理学会年会, 25 Sep. 2014

  
• Structure studies on G-protein coupled receptors

  So Iwata

  6th International Society for Neurochemistry Special Conference, 20 Sep. 2014

  
• Serial Femtosecond crystallography at SACLA

  So Iwata

  8th Asia Oceania Forum for Synchrotron Radiation Research, 15 Sep. 2014

  
• Molecular basis of antihistamine specificity against Human Histamine H1 receptor

  So Iwata

  REGPEP2014, 07 Sep. 2014

  
• ヒスタミンH1受容体の立体構造に基づいた各種抗ヒスタミン薬作用機構の理解

  岩田 想

  第一回 GSK皮膚免疫カンファレンス, 19 Jul. 2014

  
• ヒスタミンH1受容体結晶構造に基づく抗ヒスタミン薬選択性の分子機構

  岩田 想

  アレロック全国講演会, 28 Jun. 2014

  
• Membrane Protein Structures and Drug Discovery

  So Iwata

  日本ケミカルバイオロジー学会 第９回年会, 11 Jun. 2014

  
• ヒスタミンH1受容体の構造と抗ヒスタミン薬選択性の分子機構

  So Iwata

  The 113th Annual Meeting of the Japanese Dermatological Association, 01 Jun. 2014

  
• ヒスタミンH１受容体結晶構造に基づく抗ヒスタミン薬選択性の分子機構

  So Iwata

  The 26th Spring Meeting of Japanese Society of Allergology, 11 May 2014

  
• Structural studies on drug-target membrane proteins

  So Iwata

  第87回日本薬理学会年会, 19 Mar. 2014

  
• 加速・深化する創薬ターゲット膜タンパク質構造生物学

  岩田 想

  第8回 炎症・脂質代謝・メタボリサーチフォーラム, 22 Feb. 2014

  
• Membrane Protein Structures and Drug Discovery

  So Iwata

  第36回日本分子生物学会年会, 03 Dec. 2013

  
• ヒスタミンH1受容体の構造に基づく抗ヒスタミン薬選択性の分子機構

  岩田 想

  第17回日本ヒスタミン学会, 22 Nov. 2013

  
• Structural Studies on G-protein coupled receptors: state of the art and future

  So Iwata

  第31回メディシナルケミストリーシンポジウム, 20 Nov. 2013

  
• Structural studies on human anion exchanger 1

  So Iwata

  BBTS Red Cell Meeting, 16 Oct. 2013

  
• Protein Crystallography

  So Iwata

  第7回 放射光科学アジアオセアニアフォーラム, 30 Sep. 2013

  
• Recent progress in structural biology at SACLA

  So Iwata

  平成25年度化学系学協会東北大会及び日本化学会東北支部70周年記念国際会議, 28 Sep. 2013

  
• 創薬応用へ向けての膜タンパク質構造解析加速・深化技術

  岩田 想

  創薬等支援基盤プラットフォーム公開シンポジウム, 24 Sep. 2013

  
• G蛋白質共役型受容体の機能と構造

  So Iwata

  The 86th Annual Meeting of the Japanese Biochemical Society, 11 Sep. 2013

  
• Pipeline for Mammalian Membrane-Protein Structures

  So Iwata

  7th International Conference on Structural Genomics, 29 Jul. 2013

  
• Structural studies on G-protein coupled receptors

  So Iwata

  The 2nd NRPB international symposium and workshop for Membrane Proteins: Function, Structures, and Diseases, 22 May 2013

  
• 創薬ターゲット膜タンパク質に対する構造ベース創薬の可能性

  岩田 想

  国際バイオテクノロジーシンポジウム, 09 May 2013

  
• Production, Crystallization and Structure Determination of Mammalian Membrane Proteins

  So Iwata

  CBR industry-academia minisymposium, 24 Apr. 2013, Invited

  
• Gタンパク質共益受容体の構造と機能

  岩田 想

  第90回日本生理学会大会, 27 Mar. 2013

  
• Structures and Mechanism of G-protein Coupled Receptors

  So Iwata

  The 37th Lorne Conference on Protein in Australia, 14 Feb. 2013

  
• Crystallization of mammalian membrane proteins using antibody fragments

  So Iwata

  Protein Structure and Function 2013, 10 Feb. 2013

  
• Crystallization of Mammalian Membrane Proteins using Antibody Fragments

  So Iwata

  The 4th NIH Roadmap Meeting on "Membrane Protein Technologies", 28 Nov. 2012

  

Books and Other Publications

• 糖尿病学2016

  岩田 想

  診断と治療社, May 2016, Not refereed

  
• Structural Biology of Membrane Proteins

  So Iwata, Editor

  化学同人, Oct. 2013, Not refereed

  

Awards

• 20 Feb. 2024

  島津賞
• 1998

  Swedish Society for Biochemistry and Molecular Biology, Svedberg Award
• 1999

  Royal Swedish Academy of Sciences, Lindbom Prize
• Mar. 2007

  Japan Society for the Promotion of Science, JSPS Prize
• Mar. 2007

  The Japan Academy, Japan Academy Medal
• Mar. 2010

  Royal Swedish Academy of Sciences, Gregori Aminoff Prize
• 2012

  Minister of Education, Culture, Sports, Science and Technology, Prizes for Science and Technology

External funds: Kakenhi

• Development and clinical application of peptide-based therapeutic agents for dry eye syndrome

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields

  Hoshi University

  Seiji Shioda

  From 29 Jun. 2018, To 31 Mar. 2023, Project Closed

  PACAP;ドライアイ;角膜上皮;角膜内皮;細胞再生;細胞新生;再生;新生;PAC1;細胞の再生・新生;結晶化;スーパーアゴニスト;涙液分泌;角膜上皮再生・新生;PAC1R;涙腺;点眼薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K20392/
• Non-equilibrium-state molecular movies and their applications

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  From 28 Jun. 2019, To 31 Mar. 2024

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-8101/
• Time-resolved XFEL crystallography and rational engineering of light-driven proteins

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  岩田 想

  From 28 Jun. 2019, To 31 Mar. 2024, Granted

  X線自由電子レーザー;構造ダイナミクス;光遺伝学;フォトクロミックタンパク質;X線結晶構造解析;膜タンパク質;時分割X線結晶構造解析;チャネルロドプシン

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19H05777/
• Non-equilibrium-state molecular movies and their applications

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  岩田 想

  From 28 Jun. 2019, To 31 Mar. 2024, Granted

  総括班;高速分子動画;分子動画;X線自由電子レーザー;生体高分子;分子制御;タンパク質;構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-19H05776/
• ヒト膜タンパク質を標的とした中分子構造創薬研究の基盤構築

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  岩田 想

  From 01 Apr. 2019, To 31 Mar. 2024, Granted

  膜タンパク質;中分子;クライオ電子顕微鏡;創薬;B型肝炎ウイルス;創薬ターゲット;中分子ペプチド;クライオ電子顕微鏡単粒子解析;ウイルス感染受容体;抗ウイルス薬;抗体;ファージディスプレイ;X線結晶構造解析;構造生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H00923/
• Crystallographic study of the mammalian bile acid transporter NTCP in complex with its conformation-specific antibodies

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Norimichi Nomura

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  膜タンパク質;抗体;X線結晶構造解析;創薬ターゲット;高脂血症;胆汁酸;トランスポーター;コレステロール;膜蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06968/
• Search for the endogenous ligad based on the orphan receptor structure

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Takuya KOBAYASHI

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  モノクローナル抗体;GPCR;X線結晶構造解析;オーファン受容体;抗体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659132/
• Structure determination of histamine H1 receptor

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuro SHIMAMURA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  アレルギー;花粉症;GPCR;結晶構造解析;ヒスタミン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24370044/
• Development of antibody stabilizing active or inactive state of GPCRs.

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Takuya KOBAYASHI

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  モノクローナル抗体;GPCR;X線結晶構造解析;立体構造認識抗体;アデノシンA2a受容体;結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659059/
• Technologicaldevelopment for construction of synthetic proteins that facilitate membrane protein crystallization

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Norimichi NOMURA

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  膜蛋白質;X線結晶構造解析;結晶化リガンド;抗体フラグメント;ファージディスプレイ;膜輸送体;プァージディスプレイ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22570114/
• X-ray Crystallographic analysis of membrane-bound AAA+ protease FtsH

  Grant-in-Aid for Young Scientists (B)

  Kyoto Sangyo University;Tokyo Institute of Technology

  Ryoji SUNO

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  X線結晶構造解析;AAA+タンパク質;ATP依存性プロテアーゼ;超分子複合体;酵素;プロテアーゼ;タンパク質;AAA+ファミリータンパク質;酵素反応;構造解析;X線構造解析;ATP加水分解;品質管理

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770106/
• Structural Study on Human Red Cell Band 3 Protein, AE1.

  Grant-in-Aid for Scientific Research (C)

  Nagasaki International University

  Naotaka HAMASAKI

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  生体分子医学;バンド3タンパク質;膜貫通領域;膜タンパク質;結晶化;X線構造解析;電子線構造解析;AE1;陰イオン透過

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590322/
• Crystal structure of human Band3 (anion exchanger)

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Takuya KOBAYASHI

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  X線結晶解析;赤血球;アニオントランスポーター;バンド3;結晶構造解析;抗体;共結晶

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20370035/
• 膜蛋白質のクライオ電子顕微鏡システマティック解析を可能にするアプローチ

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  岩田 想

  From 28 Jun. 2024, To 31 Mar. 2026, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21945/
• 膜蛋白質のクライオ電子顕微鏡システマティック解析を可能にするアプローチ

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  岩田 想

  From 28 Jun. 2024, To 31 Mar. 2026, Granted

  クライオ電子顕微鏡;構造生物学;膜タンパク質;創薬;抗体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21945/

External funds: others

• 抗体を用いた膜タンパク質構造研究支援 (2023年度分)

  文部科学省, 医療研究開発推進事業費補助金

  From 01 Apr. 2023, To 31 Mar. 2024

  分担
• 抗体を用いた膜タンパク質構造研究支援 (2022年度分)

  文部科学省, 医療研究開発推進事業費補助金

  From 01 Apr. 2022, To 31 Mar. 2023

  代表
• 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援 (2021年度分)

  文部科学省, 医療研究開発推進事業費補助金

  From 01 Apr. 2021, To 31 Mar. 2022

  代表
• 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援 （平成29年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2017, To 31 Mar. 2018

  岩田 想
• 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援 （平成30年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2018, To 31 Mar. 2019

  岩田 想
• 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援 （2019年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2019, To 31 Mar. 2020

  岩田　想
• 次世代構造創薬研究を先導するヒト膜タンパク質・抗体の生産技術支援 （2020年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2020, To 31 Mar. 2021

  岩田　想

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Biochemistry

  B003, Spring, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Biochemistry

  B003, Spring, Faculty of Medicine, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Cell Biology

  L070, Spring, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Biochemistry

  B003, Spring, Faculty of Medicine, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Cell Biology

  L070, Fall, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Molecular Cell Biology

  L080, Spring, Faculty of Medicine, 0
• From Apr. 2013, To Mar. 2014

  Basic Medical Biology

  Year-long, 医学部
• From Apr. 2013, To Mar. 2014

  Molecular Cell Biology

  Spring, 医学部
• From Apr. 2014, To Mar. 2015

  Basic Medical Biology

  Year-long, 医学部
• From Apr. 2014, To Mar. 2015

  Molecular Cell Biology

  Fall, 医学部
• From Apr. 2014, To Mar. 2015

  Laboratory Course in Molecular Cell Biology

  Spring, 医学部
• From Apr. 2014, To Mar. 2015

  Laboratory visit

  Spring, 医学研究科
• From Apr. 2015, To Mar. 2016

  Molecular Cell Biology

  Spring, 医学部
• From Apr. 2015, To Mar. 2016

  Molecular Cell Biology

  Fall, 医学部
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Molecular Cell Biology

  Spring, 医学部
• From Apr. 2015, To Mar. 2016

  Molecular Cell Biology

  Fall, 医学研究科
• From Apr. 2016, To Mar. 2017

  Molecular Cell Biology

  Spring, 医学部
• From Apr. 2016, To Mar. 2017

  Molecular Cell Biology

  Fall, 医学部
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Molecular Cell Biology

  Spring, 医学部
• From Apr. 2016, To Mar. 2017

  Molecular Cell Biology

  Fall, 医学研究科
• From Apr. 2017, To Mar. 2018

  Molecular Cell Biology

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Molecular Cell Biology

  Fall, 医学部
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Molecular Cell Biology

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Biochemistry

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Biochemistry

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Frontier in Life Sciences

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Biochemistry

  Spring, 医学研究科
• From Apr. 2018, To Mar. 2019

  Molecular Cell Biology

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Molecular Cell Biology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Molecular Cell Biology

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Biochemistry

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Biochemistry

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Biochemistry

  Spring, 医学研究科
• From Apr. 2019, To Mar. 2020

  Molecular Cell Biology

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Molecular Cell Biology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Molecular Cell Biology

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Biochemistry

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Biochemistry

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Biochemistry

  Spring, 医学研究科
• From Apr. 2020, To Mar. 2021

  Molecular Cell Biology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Molecular Cell Biology

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Molecular Cell Biology

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Biochemistry

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Biochemistry

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Molecular Cell Biology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Molecular Cell Biology

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Molecular Cell Biology

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Biochemistry

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Biochemistry

  Spring, 医学部

Participation in PhD Defense

• Chemoproteomic Identification of Blue-Light-Damaged Proteins

  TOH KOHEI, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Discovery of lipid profiles in plasma-derived extracellular vesicles as biomarkers for breast cancer diagnosis

  LIU LIN, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2024
• Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin

  FURUYA　FUTOSHI, Graduate School of Medicine, Chief Examiner

  23 May 2023
• Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase

  MIZUNO RIN, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice

  YAMAMOTO ETSUKO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Magnetic Control of Cells by Chemical Fabrication of Melanin

  NISHIO KOSUKE, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Discovery of a Phase-Separating Small Molecule That Selectively Sequesters Tubulin in Cells

  GENYIR ADO, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2023
• Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe

  JUNG YEJIN, Graduate School of Medicine, Sub-chief Examiner

  23 May 2022
• Glucose as a Protein-Condensing Cellular Solute

  NODA NAOTAKA, Graduate School of Medicine, Chief Examiner

  23 May 2022
• Perampanel Inhibits α-Synuclein Transmission in Parkinson’s Disease Models

  UEDA JUN, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes

  CRISTIANE LUMI HIRATA, Graduate School of Medicine, Chief Examiner

  24 May 2021
• Dynamic Meso-Scale Anchorage of GPI-Anchored Receptors in the Plasma Membrane: Prion Protein vs. Thy1

  NEMOTO YURI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• Hydroxypropyl Cyclodextrin Improves Amiodarone-Induced Aberrant Lipid Homeostasis of Alveolar Cells

  KANAGAKI SHUHEI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022

Administration

School management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2024

  国際高等教育院 企画評価専門委員会 化学部会 委員
• From 01 Jan. 2023, To 31 Dec. 2023

  オープンキャンパス委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2023

  国際高等教育院 企画評価専門委員会 化学部会 委員
• From 01 Apr. 2009, To 31 Mar. 2011

  学生部委員会 委員
• 基礎医学生物学（WG責任者）
• From 01 Apr. 2013, To 31 Mar. 2014

  京都大学施設整備委員会 委員
• From 01 Apr. 2013, To 30 Sep. 2014

  京都大学施設整備委員会 委員
• From 05 Jul. 2013, To 31 Mar. 2019

  国際高等教育院 企画評価専門委員会 化学部会 委員
• From 01 Apr. 2019, To 31 Mar. 2020

  国際高等教育院 企画評価専門委員会 化学部会 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  国際高等教育院 企画評価専門委員会 化学部会 委員
• From 01 Apr. 2021, To 31 Mar. 2022

  国際高等教育院 企画評価専門委員会 化学部会 委員

Faculty management (title, position)

• From 01 Apr. 2017, To 31 Mar. 2019

  医学図書館運営委員会
• To 30 Sep. 2018

  医学研究科運営委員会
• From 01 Apr. 2018, To 31 Mar. 2020

  学務委員会