Basic Information

Faculty

• Faculty of Engineering

Email Address

• Email Address

  mizuta.ryosuke.6wkyoto-u.ac.jp

Academic Degree

• 23 Mar. 2020

  京都大学修士（工学）
• 24 Mar. 2023

  京都大学博士（工学）

Academic Resume (Graduate Schools)

• 京都大学, 大学院工学研究科修士課程高分子化学専攻, 修了
• 京都大学, 大学院工学研究科博士後期課程高分子化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 工学部工業化学科, 卒業

Research History

• From Apr. 2026, To Present

  Kyoto University, Graduate School of Engineering, Department of Chemical Science and Engineering, Assistant Professor
• From Oct. 2024, To Mar. 2026

  Kyoto University, Graduate School of Engineering Department of Polymer Chemistry, Assistant Professor
• From Oct. 2023, To Aug. 2024

  Scripps Research Institute, Mia Huang lab, Postdoctoral fellow
• From Apr. 2023, To Sep. 2023

  Kyoto University, Graduate School of Engineering Department of Polymer Chemistry, Postdoctoral Researcher
• From Apr. 2021, To Mar. 2023

  日本学術振興会 特別研究員（DC2）
• From Apr. 2020, To Mar. 2021

  JST-CREST [細胞外微粒子], リサーチ・アシスタント

ID,URL

• ORCID ID

  0009-0002-7416-465X

• J-Global ID

  202401000656572502

• Researcher number

  31014219

researchmap URL

• https://researchmap.jp/rmizuta3

Research

Research Interests

• 生体膜
• Biomaterial
• Extracellular Vesicles
• Drug Delivery System

Research Areas

• Nanotechnology/Materials, Polymer materials
• Nanotechnology/Materials, Nanobioscience
• Life sciences, Biomaterials

Papers

• Proximity Proteomics Maps Candidate Cellular Uptake Pathways for Cell‐Derived Nanovesicles

  Eisuke Kanao; Ryosuke Mizuta; Saki Tarao; Yukika Hara; Yuka Li; Kazunari Akiyoshi; Yasushi Ishihama; Koshi Imami; Yoshihiro Sasaki

  Small Methods, 02 Sep. 2026

  
• Click-Crosslinked Nanogels Integrated into 3D Stem Cell Spheroids Enhance Regenerative Function for Swallowing Muscle Repair

  Hideaki Okuyama; Mika Brown; Meghana Munipalle; Sara Nejati; Ran Huo; Hibiki Sakata; Ryosuke Mizuta; Yoshihiro Sasaki; Kazunari Akiyoshi; Hiroe Ohnishi; Yo Kishimoto; Koichi Omori; Jianyu Li; Luc Mongeau; Nicole Y.K. Li-Jessen

  Biomaterials, Feb. 2026, Peer-reviewed

  Access this paper :

  
• Enhancing the stability of silver nanoparticles in biomimetic environments through biomembrane hybridization

  Tatsuhiro Yokoyama; Hiroyuki Harada; Shin-ichi Sawada; Kazunari Akiyoshi; Hikaru Takaya; Ryosuke Mizuta; Yoshihiro Sasaki

  RSC Applied Interfaces, 2026, Peer-reviewed

  Access this paper :

  
• Designing Cross-Linked Nanogel Microfibers for the Fabrication of Hybrid Cell Spheroids with Potential Biomedical Applications

  Hibiki Sakata; Shunya Hayashi; Naoya Kinoshita; Hiroyuki Harada; Ryosuke Mizuta; Shin-ichi Sawada; Kazunari Akiyoshi; Yoshihiro Sasaki

  ACS Biomaterials Science & Engineering, 12 Dec. 2025, Peer-reviewed

  
• Poly(2‐Propyl‐2‐Oxazoline)‐Induced Lipid Nanotube Formation in Phospholipid Multilayers

  Ryosuke Mizuta; Tatsuhiko Murata; Mitsuru Ando; Tomoki Nishimura; Shin‐ichi Sawada; Kazunari Akiyoshi; Yoshihiro Sasaki

  Macromolecular Rapid Communications, 19 Nov. 2025, Peer-reviewed, Lead author

  
• Fluorinated Conjugated Microporous Polymers Based on Pillar[n]arenes for Removal of Water Pollutants and Their Cation Selective Adsorption

  Yuki Togari; Shunsuke Ohtani; Eisuke Kanao; Kohei Sato; Motohiro Mizuno; Kenichi Kato; Ryosuke Mizuta; Yoshihiro Sasaki; Tomoki Ogoshi

  ACS Applied Materials & Interfaces, 09 Dec. 2024, Peer-reviewed

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• A Direct Approach for Living Biomembrane Printing on a Nanoparticle

  Ryosuke Mizuta; Eisuke Kanao; Keigo Ukyo; Shusuke Kuwada; Shin-ichi Sawada; Yasushi Ishihama; Kazunari Akiyoshi; Yoshihiro Sasaki

  Nano Letters, 08 Oct. 2024, Lead author

  
• Extracellular Vesicles Comprising Carborane Prepared by a Host Exchanging Reaction as a Boron Carrier for Boron Neutron Capture Therapy

  Riku Kawasaki; Ayano Oshige; Nanami Kono; Keita Yamana; Hidetoshi Hirano; Yamato Miura; Ryuji Yorioka; Kaori Bando; Anri Tabata; Naoki Yasukawa; Masahiro Sadakane; Yu Sanada; Minoru Suzuki; Takushi Takata; Yoshinori Sakurai; Hiroki Tanaka; Dilimulati Yimiti; Shigeru Miyaki; Nobuo Adachi; Ryosuke Mizuta; Yoshihiro Sasaki; Kazunari Akiyoshi; Yoshihide Hattori; Mitsunori Kirihata; Takeshi Nagasaki; Atsushi Ikeda

  ACS Applied Materials & Interfaces, 11 Sep. 2024

  
• Enveloped Viral Replica Equipped with Spike Protein Derived from SARS-CoV-2

  Hiroto Furukawa; Sosuke Nakamura; Ryosuke Mizuta; Kentarou Sakamoto; Hiroshi Inaba; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi; Kazunori Matsuura

  ACS Synthetic Biology, 19 Jul. 2024

  
• Rapid and Highly Efficient Purification of Extracellular Vesicles Enabled by a TiO₂ Hybridized Spongy-like Polymer

  Eisuke Kanao; Koki Ishida; Ryosuke Mizuta; Yuka Li; Koshi Imami; Tetsuya Tanigawa; Yoshihiro Sasaki; Kazunari Akiyoshi; Jun Adachi; Koji Otsuka; Yasushi Ishihama; Takuya Kubo

  Analytical Chemistry, 26 Sep. 2023

  
• Efficient Selective Adsorption of SARS-CoV-2 via the Recognition of Spike Proteins Using an Affinity Spongy Monolith

  Takuya Kubo; Eisuke Kanao; Koki Ishida; Shohei Minami; Tetsuya Tanigawa; Ryosuke Mizuta; Yoshihiro Sasaki; Koji Otsuka; Takeshi Kobayashi

  Analytical Chemistry, 05 Sep. 2023

  
• A Facile Method to Coat Nanoparticles with Lipid Bilayer Membrane: Hybrid Silica Nanoparticles Disguised as Biomembrane Vesicles by Particle Penetration of Concentrated Lipid Layers

  Ryosuke Mizuta; Fumihito Inoue; Yoshihiro Sasaki; Shin‐ichi Sawada; Kazunari Akiyoshi

  Small, Mar. 2023, Lead author

  
• Reversible conjugation of biomembrane vesicles with magnetic nanoparticles using a self-assembled nanogel interface: single particle analysis using imaging flow cytometry

  Ryosuke Mizuta; Yoshihiro Sasaki; Kiyofumi Katagiri; Shin-ichi Sawada; Kazunari Akiyoshi

  Nanoscale Advances, 2022, Lead author

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• Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering

  Shin-ichi Sawada; Yuko T. Sato; Riku Kawasaki; Jun-ichi Yasuoka; Ryosuke Mizuta; Yoshihiro Sasaki; Kazunari Akiyoshi

  Biomaterials Science, 2020

  
• Magnetically Navigated Intracellular Delivery of Extracellular Vesicles Using Amphiphilic Nanogels

  Ryosuke Mizuta; Yoshihiro Sasaki; Riku Kawasaki; Kiyofumi Katagiri; Shin-ichi Sawada; Sada-atsu Mukai; Kazunari Akiyoshi

  Bioconjugate Chemistry, 21 Aug. 2019, Lead author

  

Misc.

• Extracellular vesicle hybrid engineering for DDS and medical application

  Ryosuke Mizuta; Kazunari Akiyoshi

  Drug Delivery System, 25 Mar. 2021

  

Presentations

• 細胞外界インターフェースを理解しデザインするための生体膜ナノ粒子工学

  水田涼介

  第2回マルチモダルECM若手の会2026, 15 Jan. 2026

  
• 近接依存性ラベリング技術を用いた細胞由来小胞の取り込み経路の解析

  水田 涼介; 金尾 英佑; 石濱 泰; 秋吉 一成; 佐々木 善浩

  第12回日本細胞外小胞学会学術集会, 14 Oct. 2025

  
• 細胞取り込み経路解析に向けた近接依存性ビオチン化酵素搭載細胞由来小胞の構築

  水田 涼介; 金尾 英佑; 石濱 泰; 秋吉 一成; 佐々木 善浩

  第35回バイオ・高分子シンポジウム, 31 Jul. 2025

  
• 細胞内動態解析のための近接依存性ビオチン化酵素を搭載した細胞由来小胞の構築

  水田 涼介; 金尾 英佑; 石濱 泰; 秋吉 一成; 佐々木 善浩

  日本ケミカルバイオロジー学会 第19回年会, 06 Jun. 2025

  
• 生体膜小胞を模倣したハイブリッドナノ粒子の構築と機能評価

  水田 涼介; 金尾 英佑; 澤田 晋一; 石濱 泰; 秋吉 一成; 佐々木 善浩

  第74回高分子学会年次大会, 21 May 2025

  

Books and Other Publications

• 分散・凝集技術ハンドブック = Handbook of dispersion and flocculation technology

  武田, 真一; 足立, 泰久; 大島, 広行; 川﨑, 英也; 小林, 功; 小林, 敏勝; 中村, 浩; 秋吉, 一成

  NTS, Apr. 2025

  Find Kyoto University's collection of books :

  
• 高分子材料の事典

  高分子学会; 中條, 善樹; 大山, 俊幸; 古賀, 毅; 佐藤, 尚弘; 原口, 和敏; 和田, 健彦; 青島, 貞人, 1-47 ナノゲル

  朝倉書店, Nov. 2022

  Find Kyoto University's collection of books :

  

External funds: Kakenhi

• 生体膜分子コードに基づく標的応答制御型ナノキャリアの創出

  Grant-in-Aid for Early-Career Scientists

  Basic Section 90120:Biomaterials-related

  Kyoto University

  水田 涼介

  From 01 Apr. 2026, To 31 Mar. 2029, Granted

  細胞外小胞;細胞由来小胞;生体膜;ドラッグデリバリーシステム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K21644/

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Polymer Synthesis

  H649, Spring, Graduate School of Engineering, 1.5