Basic Information

Email Address

• Email Address

  liu.pinwu.7akyoto-u.ac.jp

Professional Memberships

• Society for Neuroscienc
• The Japan Neuroscience Society

Academic Degree

• 13 Jun. 2015

  国立台湾大学修士（理学）
• 23 Mar. 2021

  京都大学博士（医科学）

Academic Resume (Undergraduate School/Majors)

• 国立中央大学, 理学部生命科学科, 卒業

Research History

• From Oct. 2023, To Sep. 2024

  Nagoya University, Research Institute of Environmental Medicine, Researcher
• From Oct. 2023, To Present

  Kyoto University, Graduate School of Medicine, Researcher
• From Apr. 2023, To Sep. 2023

  Kyoto University, Graduate School of Medicine, JSPS Postdoctoral Fellowships for Research in Japan
• From Sep. 2022, To Sep. 2023

  Nagoya University, Research Institute of Environmental Medicine, Research Collaborator
• From Oct. 2021, To Mar. 2023

  Nagoya University, Graduate School of Science, JSPS Postdoctoral Fellowships for Research in Japan
• From Apr. 2021, To Sep. 2021

  Kyoto University, Graduate School of Medicine, Researcher
• From May 2020, To Mar. 2021

  Kyoto University, Graduate School of Medicine, Research/Teaching assistant
• From Apr. 2016, To Mar. 2017

  RIKEN, Brain Science Institute, Junior Research Associate

ID,URL

• ORCID ID

  0000-0001-8053-2098

• J-Global ID

  202201018846781592

• Researcher number

  60886563

researchmap URL

• https://researchmap.jp/pinwu-liu

Research

Research Interests

• Synaptic Plasticity
• Learning and Memory

Research Areas

• Life sciences, Neuroscience - general

Papers

• A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments

  Miao Pan; Pin-Wu Liu; Yukihiro Ozawa; Fumiko Arima-Yoshida; Geyao Dong; Masahito Sawahata; Daisuke Mori; Masashi Nagase; Hajime Fujii; Shuhei Ueda; Yurie Yabuuchi; Xinzi Liu; Hajime Narita; Ayumu Konno; Hirokazu Hirai; Norio Ozaki; Kiyofumi Yamada; Hiroyuki Kidokoro; Haruhiko Bito; Hiroyuki Mizoguchi; Ayako M. Watabe; Shin-ichiro Horigane; Sayaka Takemoto-Kimura

  Translational Psychiatry, 26 Mar. 2025, Peer-reviewed

  
• Molecular Mechanisms Underlying Synaptic Tagging and Consolidation

  Yasunori Hayashi; Miquel Bosch; Pin-Wu Liu; Tomohisa Hosokawa; Takeo Saneyoshi

  Synaptic Tagging and Capture, 26 Apr. 2024, Peer-reviewed, Invited

  
• Molecular diversity and functional dynamics in the central amygdala

  Li-Feng Yeh; Shuzhen Zuo; Pin-Wu Liu

  Frontiers in Molecular Neuroscience, 14 Feb. 2024, Peer-reviewed, Invited, Corresponding author

  
• Regulation of the Stability and Localization of Post-synaptic Membrane Proteins by Liquid-Liquid Phase Separation.

  Tomohisa Hosokawa; Pin-Wu Liu

  Frontiers in physiology, Dec. 2021, Peer-reviewed, Invited

  
• Regulation of synaptic nanodomain by liquid-liquid phase separation: A novel mechanism of synaptic plasticity.

  Pin-Wu Liu; Tomohisa Hosokawa; Yasunori Hayashi

  Current opinion in neurobiology, Aug. 2021, Peer-reviewed, Lead author

  
• CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation.

  Tomohisa Hosokawa; Pin-Wu Liu; Qixu Cai; Joana S Ferreira; Florian Levet; Corey Butler; Jean-Baptiste Sibarita; Daniel Choquet; Laurent Groc; Eric Hosy; Mingjie Zhang; Yasunori Hayashi

  Nature neuroscience, Jun. 2021, Peer-reviewed, Lead author

  

Misc.

• CaMKIIの新しいシナプス可塑性機構

  林 康紀; 細川 智永; 劉 品吾; 實吉 岳郎

  生化学, Apr. 2021

  

Awards

• 20 Jun. 2023

  令和５年度花王科学奨励賞（花王芸術・科学財団）
• 03 Feb. 2023

  第３９回井上研究奨励賞（井上科学振興財団）
• 29 Jul. 2021

  第６回時実利彦記念神経科学優秀博士研究賞（公益信託時実利彦記念脳研究助成基金）

External funds: Kakenhi

• 液-液相分離を介したシナプス恒常的可塑性の新規機構

  Grant-in-Aid for Early-Career Scientists

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  劉 品吾

  From 01 Apr. 2021, To 31 Mar. 2022, Discontinued

  memory formation;synaptic plasticity;PSD;CaMKII;LLPS;Phase separation;Synapse;Homeostatic plasticity;Memory

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15188/
• Super-resolution imaging for synapse reveals structure-function correlation between sub-synaptic protein localization and synaptic plasticity

  Grant-in-Aid for Research Activity Start-up

  0704:Neuroscience, brain sciences, and related fields

  Kyoto University

  Pin-Wu Liu

  From 11 Sep. 2020, To 31 Mar. 2022, Project Closed

  Memory formation;Synaptic plasiticity;Super-resolution imaging;STORM;liquid phase separation;synaptic plasticity;memory formation;AMPAR;PSD;super-resolution imaging;Synapse;Synaptic plasticity;Memory;Super resolution;Postsynaptic Density

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K22685/
• 記憶の強化・阻害を目指したシナプス液-液相分離の形成・離散の光操作

  Grant-in-Aid for Research Activity Start-up

  0704:Neuroscience, brain sciences, and related fields

  Kyoto University

  劉 品吾

  From 31 Jul. 2024, To 31 Mar. 2026, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K23243/
• Optogenetic Control of Synaptic Liquid-Liquid Phase Separation: Mechanisms of Memory Enhancement and Inhibition

  Grant-in-Aid for Research Activity Start-up

  0704:Neuroscience, brain sciences, and related fields

  Kyoto University

  劉 品吾

  From 31 Jul. 2024, To 31 Mar. 2026, Granted

  CaMKII;AMPAR;NMDAR;GluSnFR;super-resolution imaging

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K23243/