Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 幹細胞応用研究, 教授
• Graduate School of Medicine, 医科学専攻 幹細胞応用研究, 教授

Professional Memberships

• American Society of Hematology
• 日本血液学会
• 日本循環器学会
• 日本内科学会

Academic Degree

• 博士（医学）(山梨医科大学)

Research History

• The University of Tokyo The Institute of Medical Science, Associate Professor

ID,URL

• J-Global ID

  200901000373133599

• External link

  http://www.cira.kyoto-u.ac.jp/eto/research/

researchmap URL

• https://researchmap.jp/read0050816

Research

Research Topics, Overview of the research

• Research Topics

  iPS細胞を用いた輸血製剤供給システムの開発と臨床試験

• Overview of the research

  多細胞生物は非対称性分裂によって多様な細胞を産生しながら発生し、個体を形成します。血液を一生にわたって供給している造血幹細胞や各種の血液系譜前駆細胞もまた非対称性分裂によって多種類の血液細胞を産生すると考えられています。幹細胞システムを維持するためには自己複製と分化が必要であり、この両方を同時に可能にするのが非対称性自己複製分裂です。こうした機構の分子機序の解明を継続することで、私たちはヒト多能性幹細胞から効率よく血小板や造血幹細胞をはじめとする各種血液細胞を誘導する技術を確立し、献血に依存しない輸血システムの実現および遺伝子治療を目指した基礎研究・技術改良を推進していきます。
  iPS細胞研究所は、再生医療の実現化を目指して様々な患者に対応できるiPS細胞の樹立を行ってバンク化する計画を推進しています。私たちは、iPS細胞に限定せず，iPS細胞をソースにした血小板や赤血球を大量かつ一定の品質で供給できるようにするためのバンクシステムの構築を目指します。そのために、従来の遺伝情報ネットワーク以外のエピゲノム情報を解析・応用し、特定の細胞系譜がヒト多能性幹細胞から生み出され維持されるための分子機構を明らかにしていきたいと考えています。

Research Interests

• 血小板
• 幹細胞
• Platelet biology
• Stem Cell

Research Areas

• Life sciences, Hematology and oncology
• Life sciences, Cardiology
• Life sciences, Cell biology

Papers

• The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte a-granule biogenesis

  Richard W. Lo; Ling Li; Fred G. Pluthero; Richard Leung; Koji Eto; Walter H.A. Kahr

  Blood, 06 Aug. 2020

  
• Stem cell-derived platelets

  Peter Karagiannis; Naoshi Sugimoto; Koji Eto

  Platelets, 01 Jan. 2019

  
• Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model.

  Sudip Kumar Paul; Motohiko Oshima; Ashwini Patil; Masamitsu Sone; Hisaya Kato; Yoshiro Maezawa; Hiyori Kaneko; Masaki Fukuyo; Bahityar Rahmutulla; Yasuo Ouchi; Kyoko Tsujimura; Mahito Nakanishi; Atsushi Kaneda; Atsushi Iwama; Koutaro Yokote; Koji Eto; Naoya Takayama

  Nature communications, 10 Jun. 2024

  
• Nardilysin determines hematopoietic stem cell fitness by regulating protein synthesis.

  Shinichiro Oshima; Rahul Sinha; Mikiko Ohno; Kiyoto Nishi; Koji Eto; Akifumi Takaori-Kondo; Eiichiro Nishi; Ryo Yamamoto

  Biochemical and biophysical research communications, 22 Jan. 2024

  
• A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility

  Si Jing Chen; Kazuya Hashimoto; Kosuke Fujio; Karin Hayashi; Sudip Kumar Paul; Akinori Yuzuriha; Wei-Yin Qiu; Emiri Nakamura; Maria Alejandra Kanashiro; Mio Kabata; Sou Nakamura; Naoshi Sugimoto; Atsushi Kaneda; Takuya Yamamoto; Hirohide Saito; Naoya Takayama; Koji Eto

  Nature Communications, 22 Mar. 2024

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• Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells.

  Charlotte Flahou; Tatsuya Morishima; Natsumi Higashi; Yoshikazu Hayashi; Huaigeng Xu; Bo Wang; Chaoqi Zhang; Atsushi Ninomiya; Wei-Yin Qiu; Akinori Yuzuriha; Daisuke Suzuki; Sou Nakamura; Markus Manz; Shin Kaneko; Akitsu Hotta; Hitoshi Takizawa; Koji Eto; Naoshi Sugimoto

  Biochemical and biophysical research communications, 20 Apr. 2023

  
• Production and nonclinical evaluation of an autologous iPSC-derived platelet product for the iPLAT1 clinical trial.

  Naoshi Sugimoto; Sou Nakamura; Shin Shimizu; Akiko Shigemasa; Junya Kanda; Nobuki Matsuyama; Mitsunobu Tanaka; Tomoya Hayashi; Akihiro Fuchizaki; Masayuki Nogawa; Naohide Watanabe; Shinichiro Okamoto; Makoto Handa; Akira Sawaguchi; Dai Momose; Ki-Ryang Koh; Yoshihiko Tani; Akifumi Takaori-Kondo; Koji Eto

  Blood advances, 23 Sep. 2022

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• iPLAT1: The first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study.

  Naoshi Sugimoto; Junya Kanda; Sou Nakamura; Toshiyuki Kitano; Masakatsu Hishizawa; Tadakazu Kondo; Shin Shimizu; Akiko Shigemasa; Hideyo Hirai; Yasuyuki Arai; Manabu Minami; Harue Tada; Dai Momose; Ki-Ryang Koh; Masayuki Nogawa; Naohide Watanabe; Shinichiro Okamoto; Makoto Handa; Akira Sawaguchi; Nobuki Matsuyama; Mitsunobu Tanaka; Tomoya Hayashi; Akihiro Fuchizaki; Yoshihiko Tani; Akifumi Takaori-Kondo; Koji Eto

  Blood, 16 Sep. 2022

  
• Three-dimensional microchannel reflecting cell size distribution for on-chip production of platelet-like particles

  Shinya Sakuma; Hiroki Kumon; Sou Nakamura; Yusuke Kasai; Koji Eto; Fumihito Arai

  Microfluidics and Nanofluidics, Apr. 2021

  
• Integrin αvβ3 is the marker and the regulator for Tissue-Specific stem cells.

  Umemoto Terumasa; Yamato Masayuki; Nishida Kohji; Eto Koji; Nakauchi Hirohitsu; Okano Teruo

  Cytometry Research, 2011

  
• Transfusion using blood platelets derived from embryonic stem cells and induced pluripotent stem cells

  ETO Koji

  Blood & Vessel, 01 Dec. 2008

  
• Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells.

  Naoki Itokawa; Motohiko Oshima; Shuhei Koide; Naoya Takayama; Wakako Kuribayashi; Yaeko Nakajima-Takagi; Kazumasa Aoyama; Satoshi Yamazaki; Kiyoshi Yamaguchi; Yoichi Furukawa; Koji Eto; Atsushi Iwama

  Nature communications, 16 May 2022

  
• Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs

  Masamitsu Sone; Sou Nakamura; Sachiko Umeda; Harumi Ginya; Motohiko Oshima; Maria Alejandra Kanashiro; Sudip Kumar Paul; Kanae Hashimoto; Emiri Nakamura; Yasuo Harada; Kyoko Tsujimura; Atsunori Saraya; Tomoyuki Yamaguchi; Naoshi Sugimoto; Akira Sawaguchi; Atsushi Iwama; Koji Eto; Naoya Takayama

  Stem Cell Reports, Dec. 2021

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• Microfluidic Bioreactor Made of Cyclo-Olefin Polymer for Observing On-Chip Platelet Production.

  Hiroki Kumon; Shinya Sakuma; Sou Nakamura; Hisataka Maruyama; Koji Eto; Fumihito Arai

  Micromachines, 15 Oct. 2021

  
• The greatest risk is standing still

  ETO Koji

  Blood & Vessel, 01 Oct. 2011

  
• Progress towards development of a platelet transfusion product employing iPS cells

  SUZUKI Daisuke; ETO Koji

  Rinsho Ketsueki, 2016

  
• Approach Toward the Study of Integrin αIIbβ3 Signaling Using Mouse Embryonic Stem Cells

  ETO Koji

  Blood & Vessel, 2007

  
• Stem cell therapy for skin regeneration using mesenchymal stem cells derived from the progeroid Werner syndrome-specific iPS cells

  Shinichiro Funayama; Hisaya Kato; Hiyori Kaneko; Kentaro Kosaka; Daisuke Sawada; Aki Takada-Watanabe; Takuya Minamizuka; Yusuke Baba; Masaya Koshizaka; Akira Shimamoto; Yasuo Ouchi; Atsushi Iwama; Yusuke Endo; Naoya Takayama; Koji Eto; Yoshiro Maezawa; Koutaro Yokote

  15 Jun. 2021

  
• Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis.

  Akinori Yuzuriha; Sou Nakamura; Naoshi Sugimoto; Shunsuke Kihara; Masato Nakagawa; Takuya Yamamoto; Kiyotoshi Sekiguchi; Koji Eto

  Stem cell research, May 2021

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• Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome.

  Hisaya Kato; Yoshiro Maezawa; Yasuo Ouchi; Naoya Takayama; Masamitsu Sone; Kanako Sone; Aki Takada-Watanabe; Kyoko Tsujimura; Masaya Koshizaka; Sayaka Nagasawa; Hisako Saitoh; Manami Ohtaka; Mahito Nakanishi; Hidetoshi Tahara; Akira Shimamoto; Atsushi Iwama; Koji Eto; Koutaro Yokote

  Stem cell research, May 2021

  
• The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation

  Masahiro Kiuchi; Atsushi Onodera; Kota Kokubo; Tomomi Ichikawa; Yuki Morimoto; Eiryo Kawakami; Naoya Takayama; Koji Eto; Haruhiko Koseki; Kiyoshi Hirahara; Toshinori Nakayama

  Journal of Experimental Medicine, 05 Apr. 2021

  
• Generation and manipulation of human iPSC-derived platelets.

  Naoshi Sugimoto; Koji Eto

  Cellular and molecular life sciences : CMLS, Apr. 2021

  
• Development of platelet replacement therapy using human induced pluripotent stem cells.

  Sou Nakamura; Naoshi Sugimoto; Koji Eto

  Development, growth & differentiation, Feb. 2021

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• 【血液疾患と血球分化】血小板産生における流体力学機序 乱流による血小板大量産生

  杉本 直志; 中村 壮; 江藤 浩之

  血液内科, Jan. 2021

  
• Ex vivo generation of platelet products from human iPS cells.

  Sou Nakamura; Naoshi Sugimoto; Koji Eto

  Inflammation and regeneration, 01 Dec. 2020

  
• 新規物理化学制御機構が1,000億個の血小板作製を可能にする

  中村 壮; 江藤 浩之

  臨床血液, Jun. 2020

  
• iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity.

  Daisuke Suzuki; Charlotte Flahou; Norihide Yoshikawa; Ieva Stirblyte; Yoshikazu Hayashi; Akira Sawaguchi; Marina Akasaka; Sou Nakamura; Natsumi Higashi; Huaigeng Xu; Takuya Matsumoto; Kosuke Fujio; Markus G Manz; Akitsu Hotta; Hitoshi Takizawa; Koji Eto; Naoshi Sugimoto

  Stem cell reports, 14 Jan. 2020, Peer-reviewed

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• [Novel physico-chemical regulation mechanism enables the production of 100 billion platelets].

  Sou Nakamura; Koji Eto

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2020

  
• αIIbβ3 changes gears in MKs and platelets.

  Naoshi Sugimoto; Koji Eto

  Blood, 18 Apr. 2019, Peer-reviewed

  
• iPS細胞由来巨核球系前駆細胞株を用いたアナグレリドによる血小板産生抑制機構の解明

  高石 浩司; 武内 正博; 塚本 祥吉; 高山 直也; 大島 基彦; 中村 壮; 江藤 浩之; 岩間 厚志; 横手 幸太郎; 中世古 知昭; 堺田 惠美子

  日本臨床分子医学会学術総会プログラム・抄録集, Apr. 2019

  
• [Reconstitution of the hematopoietic system and clinical applications of iPS cells].

  Naoshi Sugimoto; Koji Eto

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2019, Peer-reviewed

  
• A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production.

  Hideya Seo; Si Jing Chen; Kazuya Hashimoto; Hiroshi Endo; Yohei Nishi; Akira Ohta; Takuya Yamamoto; Akitsu Hotta; Akira Sawaguchi; Hideki Hayashi; Noritaka Koseki; George J Murphy; Kazuhiko Fukuda; Naoshi Sugimoto; Koji Eto

  Blood advances, 11 Sep. 2018, Peer-reviewed

  
• De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.

  Tsutomu Toki; Kenichi Yoshida; RuNan Wang; Sou Nakamura; Takanobu Maekawa; Kumiko Goi; Megumi C Katoh; Seiya Mizuno; Fumihiro Sugiyama; Rika Kanezaki; Tamayo Uechi; Yukari Nakajima; Yusuke Sato; Yusuke Okuno; Aiko Sato-Otsubo; Yusuke Shiozawa; Keisuke Kataoka; Yuichi Shiraishi; Masashi Sanada; Kenichi Chiba; Hiroko Tanaka; Kiminori Terui; Tomohiko Sato; Takuya Kamio; Hirotoshi Sakaguchi; Shouichi Ohga; Madoka Kuramitsu; Isao Hamaguchi; Akira Ohara; Hitoshi Kanno; Satoru Miyano; Seiji Kojima; Akira Ishiguro; Kanji Sugita; Naoya Kenmochi; Satoru Takahashi; Koji Eto; Seishi Ogawa; Etsuro Ito

  American journal of human genetics, 06 Sep. 2018

  
• 新規の物理化学調節機構が1011個の血小板製造を可能にする(Novel physico-chemical regulation mechanism enables to manufacture 1011 order platelets)

  中村 壮; 伊東 幸敬; 杉本 直志; 加藤 好一; 佐久間 臣耶; 伊藤 啓太郎; 公文 広樹; 大野 美紀子; 西 英一郎; 新井 史人; 西村 智; 江藤 浩之

  臨床血液, Sep. 2018

  
• HLAクラスI欠失ヒトiPS細胞由来血小板の抗HLA抗体およびNK細胞に対する免疫逃避(HLA class-I depleted human iPSC-derived platelets evade anti-HLA and NK cell immunity)

  杉本 直志; 鈴木 大助; シャオミン・フェング; 吉川 典秀; 赤坂 まりな; 中村 壮; 遠藤 大; 堀田 秋津; 滝澤 仁; 江藤 浩之

  臨床血液, Sep. 2018, Peer-reviewed

  
• Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.

  Yukitaka Ito; Sou Nakamura; Naoshi Sugimoto; Tomohiro Shigemori; Yoshikazu Kato; Mikiko Ohno; Shinya Sakuma; Keitaro Ito; Hiroki Kumon; Hidenori Hirose; Haruki Okamoto; Masayuki Nogawa; Mio Iwasaki; Shunsuke Kihara; Kosuke Fujio; Takuya Matsumoto; Natsumi Higashi; Kazuya Hashimoto; Akira Sawaguchi; Ken-Ichi Harimoto; Masato Nakagawa; Takuya Yamamoto; Makoto Handa; Naohide Watanabe; Eiichiro Nishi; Fumihito Arai; Satoshi Nishimura; Koji Eto

  Cell, 26 Jul. 2018, Peer-reviewed

  
• Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations

  Hiraku Takei; Yoko Edahiro; Shuichi Mano; Nami Masubuchi; Yoshihisa Mizukami; Misa Imai; Soji Morishita; Kyohei Misawa; Tomonori Ochiai; Satoshi Tsuneda; Hiroshi Endo; Sou Nakamura; Koji Eto; Akimichi Ohsaka; Marito Araki; Norio Komatsu

  British Journal of Haematology, 01 Jun. 2018, Peer-reviewed

  
• Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

  Yuko Tadokoro; Takayuki Hoshii; Satoshi Yamazaki; Koji Eto; Hideo Ema; Masahiko Kobayashi; Masaya Ueno; Kumiko Ohta; Yuriko Arai; Eiji Hara; Kenichi Harada; Masanobu Oshima; Hiroko Oshima; Fumio Arai; Akihiko Yoshimura; Hiromitsu Nakauchi; Atsushi Hirao

  Cell Stem Cell, 03 May 2018, Peer-reviewed

  
• On-chip platelet production using three dimensional microchannel

  H. Kumon; S. Sakuma; S. Nakamura; K. Eto; F. Arai

  Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 24 Apr. 2018, Peer-reviewed

  
• Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.

  Keitaro Kanda; Jiro Sakamoto; Yoshihide Matsumoto; Kozo Ikuta; Norihiro Goto; Yusuke Morita; Mikiko Ohno; Kiyoto Nishi; Koji Eto; Yuto Kimura; Yuki Nakanishi; Kanako Ikegami; Takaaki Yoshikawa; Akihisa Fukuda; Kenji Kawada; Yoshiharu Sakai; Akihiro Ito; Minoru Yoshida; Takeshi Kimura; Tsutomu Chiba; Eiichiro Nishi; Hiroshi Seno

  JCI insight, 19 Apr. 2018, Peer-reviewed

  
• iPS血小板とiPS赤血球 iPS細胞由来血小板の品質評価(献血由来血小板との違い)

  渕崎 晶弘; 森 純平; 越智 洋輔; 林 智也; 田中 光信; 寺田 周弘; 寺田 あかね; 木村 貴文; 谷 慶彦; 下垣 一成; 高橋 順子; 杉本 直志; 中村 壮; 清水 伸; 江藤 浩之

  日本輸血細胞治療学会誌, Apr. 2018

  
• Ex vivo platelet production from induced pluripotent stem cells

  SUGIMOTO Naoshi; ETO Koji

  Rinsho Ketsueki, 2018, Peer-reviewed

  
• Generation of universal donor cell source for adoptive T cell therapy using iPSC technology

  Bo Wang; Shoichi Iriguchi; Tatsuki Ueda; Norihiro Ueda; Atsutaka Minagawa; Shuichi Kitayama; Yasushi Uemura; Tetsuya Nakatsura; Koji Eto; Akitsu Hotta; Shin Kaneko

  CANCER SCIENCE, Jan. 2018, Peer-reviewed

  
• カルレチキュリン変異を有する血球前駆細胞は巨核球への分化偏向性を有する

  竹井 拓; 眞野 修一; 増渕 菜弥; 水上 喜久; 今井 美沙; 森下 総司; 枝廣 陽子; 弘中 由美; ぬで島 麻衣; 常田 聡; 遠藤 大; 中村 壮; 江藤 浩之; 大坂 顯通; 荒木 真理人; 小松 則夫

  生命科学系学会合同年次大会, Dec. 2017

  
• iPS細胞技術を用いたT細胞治療療法のためのユニバーサルドナー細胞の作製

  王 博; 入口 翔一; 上田 樹; 上田 格弘; 南川 淳隆; 喜多山 秀一; 植村 靖史; 中面 哲也; 江藤 浩之; 堀田 秋津; 金子 新

  日本癌学会総会記事, Sep. 2017, Peer-reviewed

  
• Platelet production from induced pluripotent stem cells

  N. Sugimoto; K. Eto

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Sep. 2017, Peer-reviewed

  
• Refined methods to evaluate the in vivo hemostatic function and viability of transfused human platelets in rabbit models

  Naohide Watanabe; Masayuki Nogawa; Mariko Ishiguro; Hitomi Maruyama; Masayuki Shiba; Masahiro Satake; Koji Eto; Makoto Handa

  Transfusion, 01 Aug. 2017, Peer-reviewed

  
• iPS血小板は、献血PC製剤とは別物か?

  江藤 浩之; 中村 壮; 清水 伸; 杉本 直志; 広瀬 秀徳; 重盛 智大; 伊東 幸敬; 西河 芳樹; 下垣 一成; 高橋 順子; 木村 貴文; 谷 慶彦; 寺田 周弘; 渡邊 直英; 半田 誠; 野川 誠之

  日本輸血細胞治療学会誌, Jun. 2017

  
• Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ib alpha Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets

  Shinji Hirata; Takahiko Murata; Daisuke Suzuki; Sou Nakamura; Ryoko Jono-Ohnishi; Hidenori Hirose; Akira Sawaguchi; Satoshi Nishimura; Naoshi Sugimoto; Koji Eto

  STEM CELLS TRANSLATIONAL MEDICINE, Mar. 2017, Peer-reviewed

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• Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells.

  Ayako Aihara; Tomo Koike; Natsuki Abe; Sou Nakamura; Akira Sawaguchi; Takanori Nakamura; Naoshi Sugimoto; Hiromitsu Nakauchi; Taito Nishino; Koji Eto

  Blood advances, 28 Feb. 2017, Peer-reviewed

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• A design strategy of a bioreactor for platelet generation

  KUMON Hiroki; SAKUMA Shinya; ITO Keitaro; NAKAMURA Sou; ETO Koji; FUKUDA Toshio; ARAI Fumihito

  The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec), 2017

  
• Generating blood from iPS cells

  Peter Karagiannis; Hiroshi Endo; Koji Eto

  Molecular and Cellular Biology of Platelet Formation: Implications in Health and Disease, 01 Jan. 2017, Peer-reviewed

  
• Development of iPS cell-derived blood products and production guidelines

  SUGIMOTO Naoshi; ETO Koji

  Rinsho Ketsueki, 2017, Peer-reviewed

  
• Innovation of Transfusion Medicine with iPS Cells

  Sugimoto Naoshi; Eto Koji

  Nihon Naika Gakkai Zasshi, 2017, Peer-reviewed

  
• 【血球の増加と減少】iPS細胞からの血小板分化と臨床応用

  中村 壮; 江藤 浩之

  小児内科, Jul. 2016

  
• On-chipmonitoring of megakaryocytes in shear flow environment

  Kazuya Tashiro; Shinya Sakuma; Keitaro Ito; Sou Nakamura; Koji Eto; Toshio Fukuda; Fumihito Arai

  2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015, 21 Mar. 2016, Peer-reviewed

  
• 新規低分子TPO受容体アゴニストTA-316を用いたiPS細胞由来不死化巨核球株(imMKCLs)からの血小板産生

  相原 彩子[大谷]; 小池 朋; 安部 菜月; 中村 隆典; 中村 壮; 西野 泰斗; 中内 啓光; 江藤 浩之

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

  Toshihiro Fujii; Asuka Sakata; Satoshi Nishimura; Koji Eto; Shigekazu Nagata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2015, Peer-reviewed

  
• iPS細胞研究最前線 疾患モデルから臓器再生まで(Vol.19) ヒトiPS細胞を用いた血小板・赤血球製剤の開発

  中村 壮; 江藤 浩之

  医学のあゆみ, Mar. 2015

  
• IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs

  Satoshi Nishimura; Mika Nagasaki; Shinji Kunishima; Akira Sawaguchi; Asuka Sakata; Hiroyasu Sakaguchi; Tsukasa Ohmori; Ichiro Manabe; Joseph E. Italiano; Tomiko Ryu; Naoya Takayama; Issei Komuro; Takashi Kadowaki; Koji Eto; Ryozo Nagai

  Journal of Cell Biology, 2015, Peer-reviewed

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• Characterization of mesenchymal progenitor cells in the crown and root pulp of primary teeth

  Taku Toriumi; Naoya Takayama; Miyako Murakami; Momoko Sato; Maki Yuguchi; Yosuke Yamazaki; Koji Eto; Makoto Otsu; Hiromitsu Nakauchi; Tetsuo Shirakawa; Keitaro Isokawa; Masaki J. Honda

  Biomedical Research (Japan), 2015, Peer-reviewed

  
• Hyaline cartilage formation and tumorigenesis of implanted tissues derived from human induced pluripotent stem cells.

  Taku Saito; Fumiko Yano; Daisuke Mori; Manabu Kawata; Kazuto Hoshi; Tsuyoshi Takato; Hideki Masaki; Makoto Otsu; Koji Eto; Hiromitsu Nakauchi; Ung-il Chung; Sakae Tanaka

  Biomedical research (Tokyo, Japan), 2015, Peer-reviewed

  
• ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity

  Satoshi Nishimura; Mika Nagasaki; Shinichi Okudaira; Junken Aoki; Tsukasa Ohmori; Ryunosuke Ohkawa; Kazuhiro Nakamura; Koji Igarashi; Hiroshi Yamashita; Koji Eto; Kansei Uno; Naoto Hayashi; Takashi Kadowaki; Issei Komuro; Yutaka Yatomi; Ryozo Nagai

  Diabetes, 01 Dec. 2014, Peer-reviewed

  
• 【血小板研究の最近の進歩】ヒトES/iPS細胞を用いた不死化巨核球細胞株の作製

  中村 壮; 江藤 浩之

  医学のあゆみ, Oct. 2014

  
• Generation of induced pluripotent stem cells derived from primary and secondary myelofibrosis patient samples

  Masataka Hosoi; Keiki Kumano; Kazuki Taoka; Shunya Arai; Keisuke Kataoka; Koki Ueda; Yasuhiko Kamikubo; Naoya Takayama; Makoto Otsu; Koji Eto; Hiromitsu Nakauchi; Mineo Kurokawa

  EXPERIMENTAL HEMATOLOGY, Sep. 2014, Peer-reviewed

  
• Multicolor Staining of Globin Subtypes Reveals Impaired Globin Switching During Erythropoiesis in Human Pluripotent Stem Cells

  Kiyosumi Ochi; Naoya Takayama; Shoichi Hirose; Tatsutoshi Nakahata; Hiromitsu Nakauchi; Koji Eto

  STEM CELLS TRANSLATIONAL MEDICINE, Jul. 2014, Peer-reviewed

  
• The generation of induced pluripotent stem cells (iPSCs) from patients with infantile and late-onset types of Pompe disease and the effects of treatment with acid-alpha-glucosidase in Pompe's iPSCs

  Takashi Higuchi; Shiho Kawagoe; Makoto Otsu; Yohta Shimada; Hiroshi Kobayashi; Reimi Hirayama; Koji Eto; Hiroyuki Ida; Toya Ohashi; Hiromitsu Nakauchi; Yoshikatsu Eto

  MOLECULAR GENETICS AND METABOLISM, May 2014, Peer-reviewed

  
• Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells

  Sou Nakamura; Naoya Takayama; Shinji Hirata; Hideya Seo; Hiroshi Endo; Kiyosumi Ochi; Ken-ichi Fujita; Tomo Koike; Ken-ichi Harimoto; Takeaki Dohda; Akira Watanabe; Keisuke Okita; Nobuyasu Takahashi; Akira Sawaguchi; Shinya Yamanaka; Hiromitsu Nakauchi; Satoshi Nishimura; Koji Eto

  CELL STEM CELL, Apr. 2014, Peer-reviewed

  
• Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin alpha v beta 3

  Jun Ishihara; Terumasa Umemoto; Masayuki Yamato; Yoshiko Shiratsuchi; Satoshi Takaki; Brian G. Petrich; Hiromitsu Nakauchi; Koji Eto; Toshio Kitamura; Teruo Okano

  INTERNATIONAL JOURNAL OF HEMATOLOGY, Apr. 2014, Peer-reviewed

  
• ヒト巨核球の自己複製と成熟スイッチの制御機構

  江藤 浩之; 中村 壮

  日本血栓止血学会誌, Apr. 2014

  
• A Chemical Probe that Labels Human Pluripotent Stem Cells

  Nao Hirata; Masato Nakagawa; Yuto Fujibayashi; Kaori Yamauchi; Asako Murata; Itsunari Minami; Maiko Tomioka; Takayuki Kondo; Ting-Fang Kuo; Hiroshi Endo; Haruhisa Inoue; Shin-ichi Sato; Shin Ando; Yoshinori Kawazoe; Kazuhiro Aiba; Koh Nagata; Eihachiro Kawase; Young-Tae Chang; Hirofumi Suemori; Koji Eto; Hiromitsu Nakauchi; Shinya Yamanaka; Norio Nakatsuji; Kazumitsu Ueda; Motonari Uesugi

  CELL REPORTS, Mar. 2014, Peer-reviewed

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• Adipose Tissue Remodeling, Chronic Inflammation and T-cell-macrophage Interactions in Obesity Visualized by in vivo Molecular Imaging Method

  Satoshi Nishimura; Mika Nagasaki; Ichiro Manabe; Koji Eto; Takashi Kadowaki; Ryozo Nagai

  Inflammation Research, 2014, Peer-reviewed

  
• Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells

  Sho-Ichi Hirose; Naoya Takayama; Sou Nakamura; Kazumichi Nagasawa; Kiyosumi Ochi; Shinji Hirata; Satoshi Yamazaki; Tomoyuki Yamaguchi; Makoto Otsu; Shinya Sano; Nobuyasu Takahashi; Akira Sawaguchi; Mamoru Ito; Takashi Kato; Hiromitsu Nakauchi; Koji Eto

  Stem Cell Reports, 17 Dec. 2013, Peer-reviewed

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• Adipose natural regulatory B cells negatively control adipose tissue inflammation

  Satoshi Nishimura; Ichiro Manabe; Satoshi Takaki; Mika Nagasaki; Makoto Otsu; Hiroshi Yamashita; Junichi Sugita; Kotaro Yoshimura; Koji Eto; Issei Komuro; Takashi Kadowaki; Ryozo Nagai

  Cell Metabolism, 05 Nov. 2013, Peer-reviewed

  
• Clinical application strategy by iPS cells

  ETO Koji

  Rinsho Ketsueki, 30 Oct. 2013

  
• Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling

  Shinji Hirata; Naoya Takayama; Ryoko Jono-Ohnishi; Hiroshi Endo; Sou Nakamura; Takeaki Dohda; Masanori Nishi; Yuhei Hamazaki; Ei-Ichi Ishii; Shin Kaneko; Makoto Otsu; Hiromitsu Nakauchi; Shinji Kunishima; Koji Eto

  Journal of Clinical Investigation, 03 Sep. 2013, Peer-reviewed

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• Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation

  Taku Saito; Fumiko Yano; Daisuke Mori; Shinsuke Ohba; Hironori Hojo; Makoto Otsu; Koji Eto; Hiromitsu Nakauchi; Sakae Tanaka; Ung-il Chung; Hiroshi Kawaguchi

  PLOS ONE, Sep. 2013, Peer-reviewed

  
• Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes

  Yosuke Nakagawa; Sou Nakamura; Masahiro Nakajima; Hiroshi Endo; Takeaki Dohda; Naoya Takayama; Hiromitsu Nakauchi; Fumihito Arai; Toshio Fukuda; Koji Eto

  EXPERIMENTAL HEMATOLOGY, Aug. 2013, Peer-reviewed

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• WASPs and WAVEs: From molecular function to physiology in hematopoietic cells

  Atsushi Oda; Koji Eto

  SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, Apr. 2013, Peer-reviewed

  
• ヒト多能性幹細胞を用いた血小板産生技術の開発

  中村 壮; 江藤 浩之

  日本血栓止血学会誌, Apr. 2013

  
• Role of SOX17 in hematopoietic development from human embryonic stem cells

  Yaeko Nakajima-Takagi; Mitsujiro Osawa; Motohiko Oshima; Haruna Takagi; Satoru Miyagi; Mitsuhiro Endoh; Takaho A. Endo; Naoya Takayama; Koji Eto; Tetsuro Toyoda; Haruhiko Koseki; Hiromitsu Nakauchi; Atsushi Iwama

  Blood, 17 Jan. 2013, Peer-reviewed

  
• Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.

  Toshinobu Nishimura; Shin Kaneko; Ai Kawana-Tachikawa; Yoko Tajima; Haruo Goto; Dayong Zhu; Kaori Nakayama-Hosoya; Shoichi Iriguchi; Yasushi Uemura; Takafumi Shimizu; Naoya Takayama; Daisuke Yamada; Ken Nishimura; Manami Ohtaka; Nobukazu Watanabe; Satoshi Takahashi; Aikichi Iwamoto; Haruhiko Koseki; Mahito Nakanishi; Koji Eto; Hiromitsu Nakauchi

  Cell stem cell, 03 Jan. 2013, Peer-reviewed

  
• Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application

  Naoya Takayama; Koji Eto

  CELLULAR AND MOLECULAR LIFE SCIENCES, Oct. 2012, Peer-reviewed

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• Identification of Hic-5 as a novel regulatory factor for integrin aIIb ss 3 activation and platelet aggregation in mice

  J. -R. Kim-Kaneyama; A. Miyauchi; X. -F. Lei; S. Arita; T. Mino; N. Takeda; K. Kou; K. Eto; T. Yoshida; T. Miyazaki; S. Shioda; A. Miyazaki

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Sep. 2012, Peer-reviewed

  
• Guest editorial: The contribution of pluripotent stem cells to blood cells

  Koji Eto

  INTERNATIONAL JOURNAL OF HEMATOLOGY, Jun. 2012, Peer-reviewed

  
• Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

  Keiki Kumano; Shunya Arai; Masataka Hosoi; Kazuki Taoka; Naoya Takayama; Makoto Otsu; Genta Nagae; Koki Ueda; Kumi Nakazaki; Yasuhiko Kamikubo; Koji Eto; Hiroyuki Aburatani; Hiromitsu Nakauchi; Mineo Kurokawa

  BLOOD, Jun. 2012, Peer-reviewed

  
• PKA/CREB Signaling Triggers Initiation of Endothelial and Hematopoietic Cell Differentiation via Etv2 Induction

  Kohei Yamamizu; Taichi Matsunaga; Shiori Katayama; Hiroshi Kataoka; Naoya Takayama; Koji Eto; Shin-Ichi Nishikawa; Jun K. Yamashita

  STEM CELLS, Apr. 2012, Peer-reviewed

  
• ヒト多能性幹細胞を用いた血小板再生

  中村 壮; 高山 直也; 江藤 浩之

  人工血液, Apr. 2012

  
• In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

  Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Shigeru Kakuta; Yoichiro Iwakura; Naoya Takayama; Jun Ooehara; Makoto Otsu; Akihide Kamiya; Brian G. Petrich; Tetsumei Urano; Takafumi Kadono; Shinichi Sato; Atsu Aiba; Hiroshi Yamashita; Seiryo Sugiura; Takashi Kadowaki; Hiromitsu Nakauchi; Koji Eto; Ryozo Nagai

  BLOOD, Feb. 2012, Peer-reviewed

  
• Novel therapeutic strategy for hematological diseases using iPS cell-banking

  Eto K

  Rinsho Ketsueki 53(7):658-663, 2012, Peer-reviewed

  
• Integrin-alpha v beta 3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells

  Terumasa Umemoto; Masayuki Yamato; Jun Ishihara; Yoshiko Shiratsuchi; Mika Utsumi; Yohei Morita; Hiroko Tsukui; Masao Terasawa; Takehiko Shibata; Kohji Nishida; Yoshiro Kobayashi; Brian G. Petrich; Hiromitsu Nakauchi; Koji Eto; Teruo Okano

  BLOOD, Jan. 2012, Peer-reviewed

  
• In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells

  Naoya Takayama; Koji Eto

  Methods in Molecular Biology, 2012, Peer-reviewed

  
• Modeling Congenital Amegakaryocytic Thrombocytopenia Using Patient-Specific Induced Pluripotent Stem Cells

  Takayama Naoya; Hirata Shinji; Jono-Ohnishi Ryoko; Nakamura Sou; Hirose Sho-ichi; Endo Hiroshi; Nishi Masanori; Hamazaki Yuhei; Kaneko Shin; Ishii Eiichi; Nakauchi Hiromitsu; Kunishima Shinji; Eto Koji

  BLOOD, 18 Nov. 2011, Peer-reviewed

  
• In Vitro Generation of Mature T Lymphocytes From Human Ips Cells and Genetic Analysis of TCR Gene Rearrangements

  Nishimura Toshinobu; Kaneko Shin; Tajima Yoko; Takayama Naoya; Tachikawa-Kawana Ai; Eto Koji; Nakauchi Hiromitsu

  BLOOD, 18 Nov. 2011, Peer-reviewed

  
• Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells

  N. Takayama; S. Nishimura; S. Nakamura; T. Shimizu; R. Ohnishi; H. Endo; T. Yamaguchi; M. Otsu; K. Nishimura; M. Nakanishi; A. Sawaguchi; R. Nagai; K. Takahashi; S. Yamanaka; H. Nakauchi; K. Eto

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Jul. 2011, Peer-reviewed

  
• Heterozygous ITGA2B R995W mutation inducing constitutive activation of the alpha IIb beta 3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

  Shinji Kunishima; Hirokazu Kashiwagi; Makoto Otsu; Naoya Takayama; Koji Eto; Masafumi Onodera; Yuji Miyajima; Yasushi Takamatsu; Junji Suzumiya; Kousaku Matsubara; Yoshiaki Tomiyama; Hidehiko Saito

  BLOOD, May 2011, Peer-reviewed

  
• [Potential usefulness of human iPS cells on the generation of platelets].

  N. Takayama; K. Eto; H. Nakauchi

  Nihon rinsho. Japanese journal of clinical medicine, 2011, Peer-reviewed

  
• Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells

  Naoya Takayama; Satoshi Nishimura; Sou Nakamura; Takafumi Shimizu; Ryoko Ohnishi; Hiroshi Endo; Tomoyuki Yamaguchi; Makoto Otsu; Ken Nishimura; Mahito Nakanishi; Akira Sawaguchi; Ryozo Nagai; Kazutoshi Takahashi; Shinya Yamanaka; Hiromitsu Nakauchi; Koji Eto

  JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 2010, Peer-reviewed

  
• Generation of Monoclonal TCR-Expressing Human T-Lineage Lymphocytes From Induced Pluripotent Stem Cells of Single Peripheral T-Lymphocyte Origin

  Nishimura Toshinobu; Kaneko Shin; Gotoh Haruo; Takayama Naoya; Shimizu Takafumi; Iriguchi Shoichi; Tajima Yoko; Yasui Yutaka; Watanabe Nobukazu; Takahashi Satoshi; Eto Koji; Nakauchi Hiromitsu

  BLOOD, 19 Nov. 2010, Peer-reviewed

  
• Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder- and Serum-Free Defined Conditions

  Yohei Hayashi; Techuan Chan; Masaki Warashina; Masakazu Fukuda; Takashi Ariizumi; Koji Okabayashi; Naoya Takayama; Makoto Otsu; Koji Eto; Miho Kusuda Furue; Tatsuo Michiue; Kiyoshi Ohnuma; Hiromitsu Nakauchi; Makoto Asashima

  PLOS ONE, Nov. 2010, Peer-reviewed

  
• Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2 EMBRYONIC/NEONATAL LETHALITY OF CLEC-2-DEFICIENT MICE BY BLOOD/LYMPHATIC MISCONNECTIONS AND IMPAIRED THROMBUS FORMATION OF CLEC-2-DEFICIENT PLATELETS

  Katsue Suzuki-Inoue; Osamu Inoue; Guo Ding; Satoshi Nishimura; Kazuya Hokamura; Koji Eto; Hirokazu Kashiwagi; Yoshiaki Tomiyama; Yutaka Yatomi; Kazuo Umemura; Yonchol Shin; Masanori Hirashima; Yukio Ozaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2010, Peer-reviewed

  
• 体性幹細胞とiPS細胞 ヒトiPS細胞からの血液細胞誘導(医療応用への可能性)

  高山 直也; 西村 智; 中村 壮; 清水 崇史; 大西 椋子; 遠藤 大; 大津 真; 高橋 和利; 山中 伸弥; 江藤 浩之; 中内 啓光

  Cytometry Research, Jun. 2010

  
• iPS・幹細胞研究によってわかってきた血栓・血管医学の最前線 ヒトES細胞・iPS細胞をソースとするin vitro血小板産生モデル

  江藤 浩之; 高山 直也; 大西 椋子; 中村 壮; 西村 智; 國島 伸治; 大津 真; 中内 啓光

  日本血栓止血学会誌, Apr. 2010

  
• Lnk regulates integrin alpha IIb beta 3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

  Hitoshi Takizawa; Satoshi Nishimura; Naoya Takayama; Atsushi Oda; Hidekazu Nishikii; Yohei Morita; Sei Kakinuma; Satoshi Yamazaki; Satoshi Okamura; Noriko Tamura; Shinya Goto; Akira Sawaguchi; Ichiro Manabe; Kiyoshi Takatsu; Hiromitsu Nakauchi; Satoshi Takaki; Koji Eto

  JOURNAL OF CLINICAL INVESTIGATION, Jan. 2010, Peer-reviewed

  
• Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.

  Hitoshi Takizawa; Satoshi Nishimura; Naoya Takayama; Atsushi Oda; Hidekazu Nishikii; Yohei Morita; Sei Kakinuma; Satoshi Yamazaki; Satoshi Okamura; Noriko Tamura; Shinya Goto; Akira Sawaguchi; Ichiro Manabe; Kiyoshi Takatsu; Hiromitsu Nakauchi; Satoshi Takaki; Koji Eto

  The Journal of clinical investigation, Jan. 2010, Peer-reviewed

  
• Evidence That Integrin alpha IIb beta 3-dependent Interaction of Mast Cells with Fibrinogen Exacerbates Chronic Inflammation

  Toshihiko Oki; Koji Eto; Kumi Izawa; Yoshinori Yamanishi; Naoki Inagaki; Jon Frampton; Toshio Kitamura; Jiro Kitaura

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2009, Peer-reviewed

  
• c-MYC再活性化に伴うヒトiPS細胞からの効率の良い巨核球/血小板産生法の確立

  高山 直也; 中村 壮; 大西 椋子; 澤口 朗; 高橋 和利; 山中 伸弥; 江藤 浩之; 中内 啓光

  臨床血液, Sep. 2009

  
• Definitive proof for direct reprogramming of hematopoietic cells to pluripotency

  Motohito Okabe; Makoto Otsu; Dong Hyuck Ahn; Toshihiro Kobayashi; Yohei Morita; Yukiko Wakiyama; Masafumi Onodera; Koji Eto; Hideo Ema; Hiromitsu Nakauchi

  BLOOD, Aug. 2009, Peer-reviewed

  
• CD8(+) effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

  Satoshi Nishimura; Ichiro Manabe; Mika Nagasaki; Koji Eto; Hiroshi Yamashita; Mitsuru Ohsugi; Makoto Otsu; Kazuo Hara; Kohjiro Ueki; Seiryo Sugiura; Kotaro Yoshimura; Takashi Kadowaki; Ryozo Nagai

  NATURE MEDICINE, Aug. 2009, Peer-reviewed

  
• Stepwise Development of Hematopoietic Stem Cells from Embryonic Stem Cells

  Kenji Matsumoto; Takayuki Isagawa; Toshinobu Nishimura; Takunori Ogaeri; Koji Eto; Satsuki Miyazaki; Jun-ichi Miyazaki; Hiroyuki Aburatani; Hiromitsu Nakauchi; Hideo Ema

  PLOS ONE, Mar. 2009, Peer-reviewed

  
• TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation

  Satoshi Yamazaki; Atsushi Iwama; Shin-ichiro Takayanagi; Koji Eto; Hideo Ema; Hiromitsu Nakauchi

  BLOOD, Feb. 2009, Peer-reviewed

  
• The Actin Polymerization Regulator WAVE2 Is Required for Early Bone Marrow Repopulation by Hematopoietic Stem Cells

  Takunori Ogaeri; Koji Eto; Makoto Otsu; Hideo Ema; Hiromitsu Nakauchi

  STEM CELLS, 2009, Peer-reviewed

  
• ヒトES細胞/iPS細胞をソースとする血液分化誘導法の樹立 ES(iPS)-Sac法の可能性

  高山 直也; 中村 壮; 大西 椋子; 三木 敬三郎; 澤口 朗; 江藤 浩之; 中内 啓光

  臨床血液, Sep. 2008

  
• ES細胞/iPS細胞から産生した血小板が有用であるための戦略

  錦井 秀和; 中村 壮; 高山 直也; 江藤 浩之; 中内 啓光

  臨床血液, Sep. 2008

  
• Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells

  Hidekazu Nishikii; Koji Eto; Noriko Tamura; Koichi Hattori; Beate Heissig; Taisuke Kanaji; Akira Sawaguchi; Shinya Goto; Jerry Ware; Hiromitsu Nakauchi

  JOURNAL OF EXPERIMENTAL MEDICINE, Aug. 2008, Peer-reviewed

  
• Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals

  Hitoshi Takizawa; Koji Eto; Atsuko Yoshikawa; Hiromitsu Nakauchi; Kiyoshi Takatsu; Satoshi Takaki

  EXPERIMENTAL HEMATOLOGY, Jul. 2008, Peer-reviewed

  
• Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors

  Naoya Takayama; Hidekazu Nishikii; Joichi Usui; Hiroko Tsukui; Akira Sawaguchi; Takashi Hiroyama; Koji Eto; Hirornitsu Nakauchi

  BLOOD, Jun. 2008, Peer-reviewed

  
• 再生医学とサイトメトリー ES・iPS細胞由来血小板製剤の産業化プロジェクト

  江藤 浩之; 高山 直也; 中内 啓光; 中村 壮; 三木 敬三郎

  Cytometry Research, Jun. 2008

  
• Calyculin A retraction of mature megakaryocytes proplatelets from embryonic stem cells

  Satoshi Tamaru; Kenji Kitajima; Tohru Nakano; Koji Eto; Akira Yazaki; Toshihiko Kobayashi; Takeshi Matsumoto; Hideo Wada; Naoyuki Katayama; Masakatsu Nishikawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2008, Peer-reviewed

  
• Transfusion therapy by blood platelets derived from embryonic stem cells or induced pluripotent stem cells

  Koji Eto; Hiromitsu Nakauchi

  Drug Delivery System, 2008, Peer-reviewed

  
• The WAVE2/Abi 1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery

  Koji Eto; Hidekazu Nishikii; Takunori Ogaeri; Shiro Suetsugu; Akihide Kamiya; Toshihiro Kobayashi; Daisuke Yamazaki; Atsushi Oda; Tadaorni Takenawa; Hirornitsu Nakauchi

  BLOOD, Nov. 2007, Peer-reviewed

  
• Cytokine signaling, lipid raft clustering, and HSC hibernation

  Satoshi Yamazaki; Atsushi Iwama; Yohei Morita; Koji Eto; Hideo Ema; Hiromitsu Nakauchi

  HEMATOPOIETIC STEM CELLS VI, 2007, Peer-reviewed

  
• Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

  Satoshi Yamazaki; Atsushi Iwama; Shin-ihiro Takayanagi; Yohei Morita; Koji Eto; Hideo Ema; Hiromitsu Nakauchi

  EMBO JOURNAL, Aug. 2006, Peer-reviewed

  
• Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain

  SI Takayanagi; T Hiroyarna; S Yamazaki; T Nakajima; Y Morita; J Usui; K Eto; T Motohashi; K Shiomi; K Keino-Masu; M Masu; Y Oike; S Mori; N Yoshida; A Iwama; H Nakauchi

  BLOOD, Jun. 2006, Peer-reviewed

  
• A role for PKC theta in outside-in alpha(IIb)beta(3) signaling

  A Soriani; B Moran; M De Virgilio; T Kawakami; A Altman; C Lowell; K Eto; SJ Shattil

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Mar. 2006, Peer-reviewed

  
• Integrin alpha(IIb)beta(3) induces the adhesion and activation of mast cells through interaction with fibrinogen

  T Oki; J Kitaura; K Eto; Y Lu; M Maeda-Yamamoto; Inagaki, I; H Nagai; Y Yamanishi; H Nakajina; H Kumagai; T Kitamura

  JOURNAL OF IMMUNOLOGY, Jan. 2006, Peer-reviewed

  
• Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development

  A Matsubara; A Iwama; S Yamazaki; C Furuta; R Hirasawa; Y Morita; M Osawa; T Motohashi; K Eto; H Ema; T Kitamura; D Vestweber; H Nakauchi

  JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 2005, Peer-reviewed

  
• 造血アダプターLnkによる血栓形成分子機構

  江藤 浩之; 錦井 秀和; 田村 典子; 小田 淳; 後藤 信哉

  日本血栓止血学会誌, Oct. 2005, Peer-reviewed

  
• Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases

  J Kitaura; K Eto; T Kinoshita; Y Kawakami; M Leitges; CA Lowell; T Kawakami

  JOURNAL OF IMMUNOLOGY, Apr. 2005, Peer-reviewed

  
• Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta

  CS Buensuceso; A Obergfell; A Soriani; K Eto; WB Kiosses; EG Arias-Salgado; T Kawakami; SJ Shattil

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2005, Peer-reviewed

  
• Talin binding to integrin beta tails: A final common step in integrin activation

  S Tadokoro; SJ Shattil; K Eto; Tai, V; RC Liddington; JM de Pereda; MH Ginsberg; DA Calderwood

  SCIENCE, Oct. 2003, Peer-reviewed

  
• Development and analysis of megakaryocytes from murine embryonic stem cells

  K Eto; AL Leavitt; T Nakano; SJ Shattil

  DIFFERENTIATION OF EMBRYONIC STEM CELLS, 2003, Peer-reviewed

  
• Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

  T Yamauchi; J Kamon; Y Minokoshi; Y Ito; H Waki; S Uchida; S Yamashita; M Noda; S Kita; K Ueki; K Eto; Y Akanuma; P Froguel; F Foufelle; P Ferre; D Carling; S Kimura; R Nagai; BB Kahn; T Kadowaki

  NATURE MEDICINE, Nov. 2002, Peer-reviewed

  
• Application of ex vivo flow chamber system for assessment of stent thrombosis

  M Sakakibara; S Goto; K Eto; N Tamura; T Isshiki; S Handa

  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Aug. 2002, Peer-reviewed

  
• Relationships between Rap1b, affinity modulation of integrin alpha(IIb)beta(3), and the actin cytoskeleton

  A Bertoni; S Tadokoro; K Eto; N Pampori; LV Parise; GC White; SJ Shattil

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2002, Peer-reviewed

  
• Functional significance of adenosine 5 '-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ib alpha induced by conditions of high shear rate

  S Goto; N Tamura; K Eto; Y Ikeda; S Handa

  CIRCULATION, May 2002, Peer-reviewed

  
• Functional classification of ADAMs based on a conserved motif for binding to integrin alpha(9)beta(1) - Implications for sperm-egg binding and other cell interactions

  K Eto; C Huet; T Tarui; S Kupriyanov; HZ Liu; W Puzon-McLaughlin; XP Zhang; D Sheppard; E Engvall; Y Takada

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2002, Peer-reviewed

  
• Coordinate interactions of Csk, Src, and Syk kinases with alpha IIb beta 3 initiate integrin signaling to the cytoskeleton

  A Obergfell; K Eto; A Mocsai; C Buensuceso; SL Moores; JS Brugge; CA Lowell; SJ Shattil

  JOURNAL OF CELL BIOLOGY, Apr. 2002, Peer-reviewed

  
• Two distinct mechanisms are involved in stent thrombosis under flow conditions

  K Eto; S Goto; T Shimazaki; M Sakakibara; M Yoshida; T Isshiki; S Handa

  PLATELETS, Jun. 2001, Peer-reviewed

  
• Platelet aggregability under shear is enhanced in patients with unstable angina pectoris who developed acute myocardial infarction

  K Eto; M Ochiai; T Isshiki; S Takeshita; M Terakura; T Sato; Y Ikeda; S Handa; S Goto

  JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, Apr. 2001, Peer-reviewed

  
• RGD-independent binding of integrin alpha(9)beta(1) to the ADAM-12 and-15 disintegrin domains mediates cell-cell interaction

  B Eto; W Puzon-McLaughlin; D Sheppard; A Sehara-Fujisawa; XP Zhang; Y Takada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2000, Peer-reviewed

  
• Serial automated three-dimensional intravascular ultrasound analysis of the self-expanding radius stent

  A Oshima; M Ochiai; S Takeshita; N Yokoyama; H Mitani; K Eto; T Isshiki; T Sato

  AMERICAN JOURNAL OF CARDIOLOGY, Feb. 2000, Peer-reviewed

  
• Serial automated three-dimensional intravascular ultrasound analysis of the self-expanding radius stent

  A Oshima; M Ochiai; S Takeshita; N Yokoyama; H Mitani; K Eto; T Isshiki; T Sato

  AMERICAN JOURNAL OF CARDIOLOGY, Feb. 2000, Peer-reviewed

  
• New long-tip guiding catheters designed for right transradial coronary intervention

  M Ochiai; Y Ikari; T Yamaguchi; T Isshiki; Y Koyama; K Eto; S Takeshita; T Tamura; T Sato

  CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Feb. 2000, Peer-reviewed

  
• Different inhibiting effects of abciximab and tirofiban on platelet thrombus formation on a collagen surface under flow conditions

  T. Shimazaki; S. Goto; M. Sakakibara; K. Eto; J. Y. Kim; N. Ichikawa; M. Yoshida; Y. Nagaoka; T. Isshiki; S. Handa

  Journal of Cardiology, 2000, Peer-reviewed

  
• Impact at cilostazol on clinical and angiographic outcome after primary stenting for acute myocardial infarction

  M Ochiai; K Eto; S Takeshita; N Yokoyama; A Oshima; K Kondo; T Sato; T Isshiki

  AMERICAN JOURNAL OF CARDIOLOGY, Nov. 1999, Peer-reviewed

  
• Efficacy of transradial primary stenting in patients with acute myocardial infarction

  M Ochiai; T Isshiki; H Toyoizumi; K Eto; N Yokoyama; Y Koyama; S Takeshita; T Sato

  AMERICAN JOURNAL OF CARDIOLOGY, Mar. 1999, Peer-reviewed

  
• Aggressive diagnostic and therapeutic approach for acute coronary syndrome

  M. Ochiai; N. Yokoyama; K. Eto; A. Oshima; Y. Koyama; S. Takeshita; T. Isshiki; T. Sato

  Journal of Cardiology, 1999, Peer-reviewed

  
• Abciximab not RGD peptide inhibits von Willebrand factor-dependent platelet activation under shear

  S. Goto; K. Eto; Y. Ikeda; S. Handa

  Lancet, 1999, Peer-reviewed

  
• Endothelium-dependent relaxation of collateral microvessels following intramuscular gene transfer of vascular endothelial growth factor in a rat model of hindlimb ischemia

  S. Takeshita; T. Isshiki; M. Ochiai; K. Eto; H. Mori; E. Tanaka; K. Umetani; T. Sato

  Journal of Cardiology, 1999, Peer-reviewed

  
• Platelet aggregation in acute coronary syndromes: use of a new aggregometer with laser light scattering to assess platelet aggregability

  K Eto; S Takeshita; M Ochiai; Y Ozaki; T Sato; T Isshiki

  CARDIOVASCULAR RESEARCH, Oct. 1998, Peer-reviewed

  
• Endothelium-dependent relaxation of collateral microvessels after intramuscular gene transfer of vascular endothelial growth factor in a rat model of hindlimb ischemia

  S Takeshita; T Isshiki; M Ochiai; K Eto; H Mori; E Tanaka; K Umetani; T Sato

  CIRCULATION, Sep. 1998, Peer-reviewed

  
• Preferential inhibition of I-Kr by MCI-154, a putative cardiotonic Ca2+ sensitizer, in guinea pig atrial cells

  K Eto; K Hashimoto; H Nakaya

  CARDIOVASCULAR RESEARCH, Jun. 1998, Peer-reviewed

  
• Significance of development of late potentials after anterior wall acute myocardial infarction despite successful primary angioplasty of the left anterior descending coronary artery

  M Ochiai; T Isshiki; K Eto; N Yokoyama; T Fusano; S Takeshita; T Sato

  AMERICAN JOURNAL OF CARDIOLOGY, May 1998, Peer-reviewed

  
• Microangiographic assessment of collateral vessel formation following direct gene transfer of vascular endothelial growth factor in rats

  S Takeshita; T Isshiki; H Mori; E Tanaka; A Tanaka; K Umetani; K Eto; Y Miyazawa; M Ochiai; T Sato

  CARDIOVASCULAR RESEARCH, Sep. 1997, Peer-reviewed

  
• Use of Cilostazol, a novel antiplatelet agent, in a post-Palmaz-Schatz stenting regimen

  M Ochiai; T Isshiki; S Takeshita; K Eto; H Toyoizumi; T Sato; H Miyashita

  AMERICAN JOURNAL OF CARDIOLOGY, Jun. 1997, Peer-reviewed

  
• Effects of ONO-2235, an aldose reductase inhibitor, on muscarinic receptors and contractile response of the urinary bladder in rats with streptozotocin-induced diabetes

  M Kanda; K Eto; N Tanabe; A Sugiyama; K Hashimoto; A Ueno

  JAPANESE JOURNAL OF PHARMACOLOGY, Mar. 1997, Peer-reviewed

  
• Use of synchrotron radiation microangiography to assess development of small collateral arteries in a rat model of hindlimb ischemia

  S Takeshita; T Isshiki; H Mori; E Tanaka; K Eto; Y Miyazawa; A Tanaka; Y Shinozaki; K Hyodo; M Ando; M Kubota; K Tanioka; K Umetani; M Ochiai; T Sato; H Miyashita

  CIRCULATION, Feb. 1997, Peer-reviewed

  
• Effects of dofetilide, a class III antiarrhythmic drug, on various ventricular arrhythmias in dogs

  JG Chen; YX Xue; K Eto; C Ni; K Hashimoto

  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Oct. 1996, Peer-reviewed

  
• Effects of the antihypoxic and neuroprotective drug, lubeluzole, on repolarization phase of canine heart assessed by monophasic action potential recording

  A Sugiyama; C Ni; J Arita; K Eto; YX Xue; K Hashimoto

  TOXICOLOGY AND APPLIED PHARMACOLOGY, Jul. 1996, Peer-reviewed

  
• Effects of MCI-154, a new cardiotonic Ca2+ sensitizer, on ventricular arrhythmias and membrane ionic currents

  K Eto; Y Xue; K Hashimoto

  EUROPEAN JOURNAL OF PHARMACOLOGY, Mar. 1996, Peer-reviewed

  
• Antiarrhythmic effects of optical isomers of disopyramide on canine ventricular arrhythmias

  M Nakamura; Y Xue; K Eto; K Hashimoto

  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Mar. 1996, Peer-reviewed

  
• Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models

  YX Xue; K Eto; Y Akie; K Hashimoto

  JAPANESE JOURNAL OF PHARMACOLOGY, Feb. 1996, Peer-reviewed

  
• NEGATIVE CHRONOTROPIC EFFECT OF ENDOTHELIN-1 MEDIATED THROUGH ET(A) RECEPTORS IN GUINEA-PIG ATRIA

  K ONO; K ETO; A SAKAMOTO; T MASAKI; K SHIBATA; T SADA; K HASHIMOTO; G TSUJIMOTO

  CIRCULATION RESEARCH, Feb. 1995, Peer-reviewed

  
• ENDOTHELIN-A RECEPTOR MEDIATES CARDIAC INHIBITION BY REGULATING CALCIUM AND POTASSIUM CURRENTS

  K ONO; G TSUJIMOTO; A SAKAMOTO; K ETO; T MASAKI; Y OZAKI; M SATAKE

  NATURE, Jul. 1994, Peer-reviewed

  

Misc.

• iPSC-derived MSC supports the hHSPCs’ expansion through the IFN pathway in an IFN-independent manner

  KANASHIRO Maria Alejandra; PAUL Sudip Kumar; SONE Masamitsu; YOSHINO Ikuyo; TSUJIMURA Kyoko; NAKAMURA Sou; ETO Koji; ETO Koji; TAKAYAMA Naoya

  日本血液学会学術集会抄録(Web), 2023

  
• Interferon signaling in macrophage derived from Werner syndrome-iPSCs promotes aberrant inflammation

  PAUL Sudip K.; SONE Masamitsu; KATO Hisaya; MAEZAWA Yoshiro; OSHIMA Motohiko; OUCHI Yasuo; IWAMA Atsushi; YOKOTE Koutaro; ETO Koji; ETO Koji; TAKAYAMA Naoya

  日本血液学会学術集会抄録(Web), 2021

  
• In vivo molecular imaging reveals multi-cellular kinetics and pro-inflammatory cytokine involvement in developing thrombus

  S. Nishimura; M. Nagasaki; Manabe, I; K. Eto; R. Nagai

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Jul. 2011

  
• Impact of cilostazol, a novel antiplatelet agent, on follow-up angiography after Palmaz-Schatz stent implantation

  M Ochiai; T Isshiki; S Takeshita; K Eto; H Mitani; Naoyuki Yokoyama; H Toyoizumi; T Sato

  AMERICAN JOURNAL OF CARDIOLOGY, Oct. 1997

  
• メタロプロテナーゼ活性はES細胞から誘導した血小板においてGPIbおよびインテグリンシグナルを制御する

  錦井 秀和; 江藤 浩之; 田村 典子; 後藤 信哉; 中内 啓光

  臨床血液, Sep. 2007

  
• Nov/CCN3 Enhances Long-Term Repopulating Activity of Mouse Hematopoietic Stem Cells Via Intergin beta 3 Signaling Collaborating with Thrombopoietin

  Jun Ishihara; Terumasa Umemoto; Masayuki Yamato; Yoshiko Shiratsuchi; Brian G. Petrich; Hiromitsu Nakauchi; Koji Eto; Toshio Kitamura; Teruo Okano

  BLOOD, Nov. 2011

  
• The cytokine signal inhibitor lnk promotes alpha IIb beta 3 integrin outside-in signaling through beta 3 tyrosine phosphorylation in platelets

  Koji Eto; Hitoshi Takiza; Satoshi Takaki; Hidekazu Nishikii; Atsushi Oda; Hiromitsu Nakauchi

  BLOOD, Nov. 2007

  
• Negative hematopoietic scaffold Lnk upregulates integrin outside-in signaling in platelets.

  K Eto; H Takizawa; H Nishikii; J Seita; A Oda; N Tamura; S Goto; K Takatsu; S Takaki; H Nakauchi

  BLOOD, Nov. 2005

  
• In vivo molecular imaging reveals parenchymal and interstitial cell cross-talks in chronic inflammatory diseases

  Satoshi Nishimura; Mika Nagasaki; Ichiro Manabe; Koji Eto; Ryozo Nagai

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• Hematopoietic differentiation from human pluripotent stem cells

  高山 直也; 江藤 浩之; 中内 啓光

  医学のあゆみ, 09 Jan. 2010

  
• 最新医学講座 iPS細胞(5)ヒトES細胞およびヒトiPS細胞を用いた血小板産生

  高山 直也; 江藤 浩之; 中内 啓光

  臨床検査, May 2009

  
• ヒトES細胞からの血小板など造血系細胞への分化誘導 (あゆみ ヒトES細胞研究のネクストステージ)

  江藤 浩之; 高山 直也; 松本 憲二

  医学のあゆみ, 13 Jan. 2007

  
• CD61 Integrin beta 3 Ligation Contributes to the Thrombopoietin-Mediated Niche Function of Mouse Hematopoietic Stem Cells

  Terumasa Umemoto; Masayuki Yamato; Yoshiko Shiratsuchi; Kenji Tsukada; Mika Utsumi; Yohei Morita; Masato Terasawa; Takehiko Shibata; Kohji Nishida; Yoshiro Kobayashi; Brian G. Petrich; Mark H. Ginsberg; Hiromitsu Nakauchi; Koji Eto; Teruo Okano

  BLOOD, Nov. 2009

  
• Hematopoietic study using iPS cells

  高山 直也; 江藤 浩之; 中内 啓光

  The Cell, Nov. 2010

  
• CONTROL OF SELF-RENEWAL ACTIVITY OF HEMATOPOIETIC STEM CELLS BY SPRED1

  Yuko Tadokoro; Koji Eto; Hideo Ema; Satoshi Yanzazaki; Akihiko Yoshimura; Hiromitsu Nakauchi; Atsushi Hirao

  EXPERIMENTAL HEMATOLOGY, Aug. 2014

  
• OE-202 Chronic Inflammation, Macrophage Recruitment and CD8+ T Cell Activation in Obese Adipose Tissue Visualized by in vivo Molecular Imaging(OE35,Metabolic Syndrome (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Nishimura Satoshi; Nagasaki Mika; Manabe Ichiro; Eto Koji; Yamashita Hiroshi; Sugiura Seiryou; Nagai Ryouzou

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• In vivo imaging reveals adipose tissue remodeling and chronic inflammation in obesity

  Satoshi Nishimura; Mika Nagasaki; Ichiro Manabe; Koji Eto; Ryozo Nagai

  ENDOCRINE JOURNAL, Mar. 2010

  
• Study of megakaryopoiesis and thrombopoiesis using human pluripotent stem cells

  高山 直也; 江藤 浩之

  医学のあゆみ, 31 Dec. 2011

  
• Generation of platelets with the ability of hemostasis in vivo from human induced pluripotent stem cells

  髙山 直也; 江藤 浩之

  血液内科, Sep. 2011

  
• Generation of functional platelets from human ES and iPS cells in vitro

  髙山 直也; 江藤 浩之; 中内 啓光

  血液・腫瘍科, Jan. 2009

  
• 白血病・リンパ腫 iPS細胞を使った血液製剤の開発

  杉本直志; 江藤浩之; 江藤浩之

  Medical Practice, 2020

  
• Development of large-scale production of highly functional platelets (Turbulence-driven production of iPSC-derived platelets)

  杉本直志; 江藤浩之; 江藤浩之

  実験医学, 2020

  
• Suppressive effects of anagrelide on cell cycle progression and the maturation of megakaryocyte progenitor cell lines in human induced pluripotent stem cells.

  Koji Takaishi; Masahiro Takeuchi; Shokichi Tsukamoto; Naoya Takayama; Motohiko Oshima; Kenji Kimura; Yusuke Isshiki; Kensuke Kayamori; Yutaro Hino; Nagisa Oshima-Hasegawa; Shio Mitsukawa; Yusuke Takeda; Naoya Mimura; Chikako Ohwada; Tohru Iseki; Sou Nakamura; Koji Eto; Atsushi Iwama; Koutaro Yokote; Chiaki Nakaseko; Emiko Sakaida

  Haematologica, 05 Sep. 2019

  
• iPS cell-derived platelets

  杉本 直志; 江藤 浩之

  日本内科学会雑誌, 10 Jul. 2019

  
• Environmental Cell-Matrix Adhesion Modulates Pluripotent Stem Cell Fate Toward Definitive Hemogenic Endothelium and Hematopoietic Progenitor Cells

  Akinori Yuzuriha; Sou Nakamura; Toshie Kusunoki; Takuya Matsumoto; Naoshi Sugimoto; Kiyotoshi Sekiguchi; Koji Eto

  BLOOD, Nov. 2018

  
• Development of iPSC-derived blood products

  杉本 直志; 江藤 浩之

  血液内科 = Hematology, Apr. 2018

  
• iPS細胞からの血小板製剤の作製

  杉本直志; 杉本直志; 江藤浩之; 江藤浩之

  日本輸血細胞治療学会誌, 2018

  
• Current approach of platelet transfusion for regenerative medicine

  鈴木 大助; 杉本 直志; 江藤 浩之

  腎臓内科・泌尿器科 = Nephrology & urology, Jun. 2017

  
• The Cutting-edge of Medicine : Innovation of transfusion medicine with iPS cells

  杉本 直志; 江藤 浩之

  日本内科学会雑誌, 10 Apr. 2017

  
• NK細胞から見たHLA欠失血小板の有用性と安全性の保証

  鈴木大助; 杉本直志; 吉川典秀; 中村壮; 遠藤大; 堀田秋津; 江藤浩之

  再生医療, 2017

  
• Synthetic miRNA Switch Technology Elucidates Heterogeneity in Regulation of Immortalized Megakaryocyte Cell Lines, Associated with Improvement of Platelet Generation Efficiency for Clinical Use

  Kazuya Hashimoto; Satoshi Matsuura; Yoshihiko Fujita; Karin Hayashi; Naoshi Sugimoto; Takuya Yamamoto; Hirohide Saito; Koji Eto

  BLOOD, Dec. 2016

  
• Natural Killer Cell Activities Against iPSCs-Derived HLA-Knockout Platelets and Megakaryocytes Reveal Perfect Rejection Profiles for Allotransfusion

  Daisuke Suzuki; Naoshi Sugimoto; Norihide Yoshikawa; Hiroshi Endo; Sou Nakamura; Akitsu Hotta; Koji Eto

  BLOOD, Dec. 2016

  
• High-Vorticity with Periodic Flow Enhances in Vitro Biogenesis of Healthy Platelets from iPSC-Derived-Megakaryocytes

  Yukitaka Ito; Sou Nakamura; Tomohiro Shigemori; Naoshi Sugimoto; Yoshikazu Kato; Kazuya Hashimoto; Naohide Watanabe; Masayuki Nogawa; Makoto Handa; Satoshi Nishimura; Koji Eto

  BLOOD, Dec. 2016

  
• Ten years of induced pluripotency: From basic mechanisms to therapeutic applications

  Peter Karagiannis; Koji Eto

  Development (Cambridge), 15 Jun. 2016

  
• Linkage between the mechanisms of thrombocytopenia and thrombopoiesis

  Koji Eto; Shinji Kunishima

  Blood, 10 Mar. 2016

  
• iPS細胞技術による血小板製剤の開発と臨床試験

  杉本直志; 江藤浩之

  日本臨床, 2016

  
• iPS細胞技術に基づくHLA欠失血小板の作製と実用可能性の検証

  鈴木大助; 杉本直志; 吉川典秀; 中村壮; 遠藤大; 堀田秋津; 江藤浩之

  再生医療, 2016

  
• Manipulating megakaryocytes to manufacture platelets ex vivo

  P. Karagiannis; K. Eto

  Journal of Thrombosis and Haemostasis, 01 Jun. 2015

  
• Platelet biogenesis wears silkworm cocoons

  Koji Eto

  Blood, 02 Apr. 2015

  
• A Novel Chemical Approach to Expand Platelets Using Immortalized Megakaryocyte Progenitor Cells Derived from Human Induced Pluripotent Stem Cells

  Ayako Otani; Tomo Koike; Natsuki Abe; Takanori Nakamura; Taito Nishino; Hiromitsu Nakauchi; Koji Eto

  BLOOD, Dec. 2014

  
• Thrombus development processes dependent on endothelial injuries: visualized by in vivo two-photon imaging

  S. Nishimura; R. Nagai; K. Eto

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Jun. 2014

  
• Morphological distinction unravels mechanisms of platelet biogenesis from bone marrow megakaryocytes

  S. Nishimura; K. Eto; R. Nagai

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Jun. 2014

  
• Disease-Specific Induced Pluripotent Stem Cells Recapitulate The Pathophysiology Of Familial Platelet Disorder With Predisposition To Acute Myelogenous Leukemia

  Shunya Arai; Hiromitsu Iiduka; Naoya Takayama; Miyauchi Masashi; Kazuki Taoka; Keisuke Kataoka; Masataka Hosoi; Keiki Kumano; Koji Eto; Mineo Kurokawa

  BLOOD, Nov. 2013

  
• Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells (vol 109, pg 12538, 2012)

  Masatoshi Kajiwara; Takashi Aoi; Keisuke Okita; Ryosuke Takahashi; Haruhisa Inoue; Naoya Takayama; Hiroshi Endo; Koji Eto; Junya Toguchida; Shinji Uemoto; Shinya Yamanaka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2012

  
• Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

  Masatoshi Kajiwara; Takashi Aoi; Keisuke Okita; Ryosuke Takahashi; Haruhisa Inoue; Naoya Takayama; Hiroshi Endo; Koji Eto; Junya Toguchida; Shinji Uemoto; Shinya Yamanaka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 2012, Peer-reviewed

  
• Production System of Platelet from iPS cells by Two-way Flow Bioreactor

  Yosuke Nakagawa; Seiichi Ikeda; Toshio Fukuda; Fumihito Arai; Sou Nakamura; Koji Eto

  2012 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS), 2012, Peer-reviewed

  
• Direct and Continuous Inhibition of ADAM17 Using a Novel Selective Inhibitor Restores Functional Platelet Yield From Human Pluripotent Stem Cells

  Shinji Hirata; Ryoko Jono-Ohnishi; Satoshi Nishimura; Naoya Takayama; Sou Nakamura; Hiromitsu Nakauchi; Takahiko Murata; Koji Eto

  BLOOD, Nov. 2011

  
• Platelet Production System Using An Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells

  Sou Nakamura; Naoya Takayama; Hiromitsu Nakauchi; Koji Eto

  BLOOD, Nov. 2011

  
• Platelet Production System Using An Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells

  Sou Nakamura; Naoya Takayama; Hiromitsu Nakauchi; Koji Eto

  BLOOD, Nov. 2011

  
• Stepwise Signaling and Low Oxygen Promote Hematopoietic Progenitor Emergence From Human Pluripotent Stem Cells

  Hiroshi Endo; Naoya Takayama; Tomo Koike; Hiromitsu Nakauchi; Koji Eto

  BLOOD, Nov. 2011

  
• Platelet and Regenerative Medicine

  ENDO Hiroshi; ETO Koji

  脈管学 : 日本脈管学会機関誌 : the journal of Japanese College of Angiology, 25 Sep. 2011

  
• Epigenetic Memory Enables,the Dominant Generation of Adult-Type Erythrocytes From Human Induced Pluripotent Stem Cells

  Naoya Takayama; Shiya Sano; Takafumi Shimizu; Ryoichiro Kawahata; Hiroshi Endo; Sou Nakamura; Seishi Ogawa; Hiromitsu Nakauchi; Koji Eto

  BLOOD, Nov. 2010

  
• Generation of monoclonal TCR-expressing human T-lineage cells from induced pluripotent stem cells of single peripheral T-lymphocyte origin

  S. Kaneko; T. Nishimura; H. Goto; N. Takayama; Y. Tajima; T. Shimizu; S. Iriguchi; M. Otsu; K. Eto; H. Nakauchi

  HUMAN GENE THERAPY, Oct. 2010

  
• Cancellation of c-MYC Silencing in Human Induced Pluripotent Stem Cells Contributes to the Efficient in Vitro Production of Platelets with the Ability of Hemostasis In Vivo.

  Naoya Takayama; Sou Nakamura; Satoshi Nishimura; Ryoko Ohnishi; Kazutoshi Takahashi; Shinya Yamanaka; Koji Eto; Hiromitsu Nakauchi

  BLOOD, Nov. 2009

  
• NOVEL THERAPEUTIC STRATEGY IN PATIENTS WHO REQUIRE REPEATED TRANSFUSION OF HUMAN LEUKOCYTE ANTIGEN-MATCHED PLATELETS DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS

  K. Eto; N. Takayama

  VOX SANGUINIS, Nov. 2009

  
• Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

  Jun Seita; Hideo Ema; Jun Ooehara; Satoshi Yamazaki; Yuko Tadokoro; Akiko Yamasaki; Koji Eto; Satoshi Takaki; Kiyoshi Takatsu; Hirornitsu Nakauchi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2007, Peer-reviewed

  
• ヒトES細胞株の樹立と再生医療 (特集 1.ヒトおよびサルのES細胞 2.再生医学のナノテクノロジー) -- (ヒトおよびサルのES細胞)

  高山 直也; 江藤 浩之

  再生医療, Feb. 2006

  
• Novel therapeutic target, link to produce platelet having an adequate haemostatic capacity without increasing thrombotic potential

  K Eto; H Nishikii; H Takizawa; N Tamura; J Seita; S Takaki; S Goto

  CIRCULATION, Oct. 2005

  
• Embryonic stem cell-derived platelets having the potential of normal hemostasis

  Koji Eto

  International Symposium on “Germ Cells, Epigenetics, Reprogramming and Embryonic Stem Cells” November 15-18, 2005 at Kyoto University, 2005, Peer-reviewed

  
• Expression of endomucin, a CD34-like sialomucin, marks definitive hematopoietic stem cells throughout development.

  A Maeda; A Iwama; K Eto; H Ema; T Kitamura; D Vestweber; H Nakauchi

  BLOOD, Nov. 2004

  
• Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling

  K Eto; R Murphy; SW Kerrigan; A Bertoni; H Stuhlmann; T Nakano; AD Leavitt; SJ Shattil

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2002, Peer-reviewed

  
• AJvW-2, an anti-vWF monoclonal antibody, inhibits enhanced platelet aggregation induced by high shear stress in platelet-rich plasma from patients with acute coronary syndromes

  K Eto; T Isshiki; H Yamamoto; S Takeshita; M Ochiai; N Yokoyama; R Yoshimoto; Y Ikeda; T Sato

  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Apr. 1999

  
• Impact of cilostazol on clinical and angiographic outcome after primary stenting for acute myocardial infarction.

  M Ochiai; T Isshiki; K Eto; N Yokoyama; Y Koyama; S Takeshita; T Sato

  AMERICAN JOURNAL OF CARDIOLOGY, Oct. 1998

  

External funds: Kakenhi

• Elucidating the fundamental mechanism of platelet biogenesis and its medical application

  Grant-in-Aid for Scientific Research (S)

  Broad Section I

  Kyoto University

  江藤 浩之

  From 05 Jul. 2021, To 31 Mar. 2026, Granted

  造血システム;血小板;巨核球;乱流;培養槽;バイオリアクター;脂質膜;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H05047/
• 流体刺激シグナルの解明に基づく連続血小板製造非定常培養機器の開発

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  江藤 浩之

  From 05 Apr. 2021, To 31 Mar. 2022, Discontinued

  血小板;巨核球;リアクター;乱流;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04957/
• Development of bone adhesive treatment with functionally modified platelets

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields

  Chiba University

  Koji Eto

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  人工血小板;iPS細胞;骨癒合;骨折治療;血小板;HLA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22675/
• Mechanism of turbulence mediated platelet biogenesis and application to ex vivo manufacturing of platelets

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  KOJI ETO

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  血小板;巨核球;iPS細胞;乱流;せん断ずり応力;バイオリアクター;ずり応力;乱流エネルギー;細胞膜;エンドペプチダーゼ;turbulence;shear stress

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H04164/
• Detection of human hematopoietic stem cells using microRNA switch technology

  Grant-in-Aid for Challenging Research (Exploratory)

  Kyoto University

  KOJI ETO

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  造血幹細胞;miRNA;mRNA;純化;発現レベル;マイクロRNA;メッセンジャーRNA;細胞純化;テクノロジー;再生医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19904/
• Elucidation of mechanism of platelet biogenesis using human iPS cells

  Grant-in-Aid for JSPS Fellows

  Kyoto University

  江藤 浩之

  From 26 Apr. 2017, To 31 Mar. 2019, Project Closed

  血小板;巨核球;スクリーニング;蛍光色素;成熟;細胞不均一;Venusレポーター;arylhydrocarbon receptor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17F17122/
• Research on cancer evolution and heterogeneity using large-scale sequencing

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  SEISHI OGAWA

  From 29 Jun. 2015, To 31 Mar. 2020, Project Closed

  RNAシーケンス;総合生物;ゲノム科学;システムゲノム科学;腫瘍学;DNAシーケンス

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-15H05909/
• Development of platelet generation system through waved miRNA regulation

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  KOJI ETO

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  血小板;バイオリアクター;ずり応力;大量培養;iPS細胞;巨核球;miRNA;ずり応用

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H03005/
• Development of 3D cultivation system that enables to control "epigenetic change" of the cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Koji ETO

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  エピゲノム;３D培養系;ずり応用;iPS細胞;造血幹細胞;巨核球;赤芽球;血小板;多能性幹細胞;細胞培養;細胞環境;3D環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24300160/
• Analysis of pathogenesis of juvenile myelomonocytic leukemia and establishment of its treatment using disease-specific iPS cells

  Grant-in-Aid for Challenging Exploratory Research

  The University of Tokyo

  Yasuhiro EBIHARA

  From 01 Apr. 2011, To 31 Mar. 2012, Project Closed

  若年性骨髄単球性白血病;iPS細胞;1型神経線維腫症;NF1;1型神経繊維腫症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659514/
• Novel drug delivery system using human iPS cell technology for recognition of cancer-related antigen

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Koji ETO

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  iPS 細胞;腫瘍がん抗原;血小板;T リンパ球;iPS細胞;Tリンパ球;癌治療;薬物運搬方法;巨核球

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650622/
• Development of high-speed closed system for analysis and isolation of rare cell populations within the blood

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  The University of Tokyo

  hiromitsu nakauchi

  From 01 Apr. 2011, To 31 Mar. 2016, Project Closed

  微小細胞;デバイス;がん;閉鎖系;医工学融合;閉鎖系高速細胞解析分離装置;末梢循環がん細胞;赤芽球;血小板;ガン

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23106004/
• Research Management

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Osaka University

  Tatsuo Arai

  From 01 Apr. 2011, To 31 Mar. 2016, Project Closed

  マイクロロボティクス;バイオアセンブラ;マイクロナノロボティクス;メカトロニクス;再生医療;幹細胞生物学;マイクロナノロボテックス

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-23106001/
• 乳児白血病細胞由来iPS細胞を用いた白血病発症メカニズムの解析

  Grant-in-Aid for Challenging Exploratory Research

  The University of Tokyo

  海老原 康博

  From 01 Apr. 2010, To 31 Mar. 2011, Project Closed

  乳児白血病;iPS細胞;MLL遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659192/
• Analysis of pathogenesis of congenital bone marrow failure syndrome and establishment of its treatment using human iPS cells

  Grant-in-Aid for Scientific Research (B)

  The University of Tokyo

  Yasuhiro EBIHARA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  iPS細胞;先天性骨髄不全症候群;重症先天性好中球減少症;ダウン症候群;RUNX1;WNT3a;好中球;巨核球;赤血球;Fanconi貧血;Kostmann症候群;Down症候群

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390321/
• New Strategy of Platelet Transfusion Independent of Donor Blood

  Grant-in-Aid for Scientific Research (B)

  Kyoto University;The University of Tokyo

  Koji ETO

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  再生医工学;人工臓器工学;iPS細胞;巨核球;血小板;c-MYC;細胞株;輸血;細胞老化;メタロプロテアーゼ;遺伝子;デバイス;MEMS;不死化細胞株

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300160/
• 造血幹細胞ニッチ、巨核球ニッチを支配するβ3インテグリン制御機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  江藤 浩之

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  造血幹細胞;β3インテグリン;outside-inシグナル;細胞周期;ニッチ;トロンボポエチン;Qutside-inシグナル;細胞分裂

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20057006/
• 血小板をヒトES細胞から誘導、高効率産生させる3次元培養技術の確立

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  The University of Tokyo

  江藤 浩之

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  ES細胞;巨核球;血小板;細胞培養;shear stress;血流;iPS細胞;培養法;scaftold

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20034014/
• Studying molecular mechanisms of megakaryocyte maturation andplatelet production derived from human embryonic stem cells

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Eto KOJI

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  ES 細胞;巨核球;血小板;細胞骨格;再生医療;輸血;ES細胞;iPS細胞;アクチン重合;造血;幹細胞;細胞環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591096/
• Elucidation of the mechanisms whereby integrin mediates platelet activation.

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Koji ETO

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  血小板;細胞骨格;インテグリン;動脈血;ES細胞;シグナル;動脈血栓;αIIbβ3;アダプター分子;Lnk, Platelet;Actin cytoskeleton;Integrin;Arterial thrombosis;ES cell;Signal transduction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17590708/
• Molecular basis of asymmetric division and lineage commitment in hematopoietic stem cells

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  Hiromitsu NAKAUCHI

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  造血幹細胞;非対称性分裂;DNAメチル化;自己複製;コミットメント;DNAメチル化酵素;Dnmt3a;Dnmt3b, hematopoietic stem cells;asymmetric division;DNA methylation;self-renewal;commitment

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17209036/
• 骨髄幹細胞の可塑性とそのメカニズム

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  中内 啓光

  From 01 Apr. 2002, To 31 Mar. 2007, Project Closed

  造血幹細胞;自己複製;bcrp-1;Lnk;サイトカイン;Endomucin;STAT5;TMTSP;myeloproliferative disorder;ポリコーム群タンパク;Bmi-1;精子幹細胞;自己複製能;Repopulation Unit;Competitive Repopulation Unit;ポリコーム遺伝子群;非対称性分裂;対娘細胞解析;blastcyst;可塑性;SP細胞;活性型STAT

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14081202/
• 骨癒合促進特化型ユニバーサルiPS血小板製剤の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Chiba University

  大鳥 精司

  From 01 Apr. 2022, To 31 Mar. 2027, Granted

  iPS細胞;血小板;巨核球;骨癒合;骨再生;iPS細胞由来血小板;サイトカイン;骨形成促進;AI

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03193/
• Development of anti-aging intervention by understanding of immune-biased megakaryocyte

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields

  Kyoto University

  江藤 浩之

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  巨核球;血小板;自然免疫;細胞老化;インターフェロン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18299/
• 骨癒合促進特化型ユニバーサルiPS血小板製剤の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Chiba University

  大鳥 精司

  From 01 Apr. 2022, To 31 Mar. 2027, Granted

  血小板;多血小板血漿;PRP;骨;iPS細胞;巨核球;骨癒合;骨再生;iPS細胞由来血小板;サイトカイン;骨形成促進;AI

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24452/

External funds: others

• 再生医療分野（iPS細胞、血小板等） （平成27年度分）

  厚生労働省 医薬品等審査迅速化事業費補助金

  From 01 Apr. 2015, To 31 Mar. 2016

  江藤　浩之
• 再生医療分野（iPS細胞、血小板等） （平成28年度分）

  医薬品等審査迅速化事業費補助金

  From 01 Apr. 2016, To 31 Mar. 2017

  江藤　浩之

Education

Participation in PhD Defense

• Platelet function of whole blood after short-term cold storage: A prospective in vitro observational study

  MATSUMI ERIKO, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart

  KASAMOTO MANABU, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi

  SUGIOKA SAYAKA, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2024
• Novel calmodulin variant p.E46K associated with severe CPVT produces robust arrhythmogenicity in human iPSC-derived cardiomyocytes

  Jingshan Gao, Graduate School of Medicine, Sub-chief Examiner

  25 Sep. 2023
• Low left atrial volume is an independent predictor of persistent hypotension after carotid artery stenting

  MAEKAWA　KOTA, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2024
• A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture

  Wen-Jin, Ho, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells

  ASAHI TAKUMA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Disrupted Cav1.2 Selectivity Causes Overlapping Long QT and Brugada Syndrome Phenotypes in CACNA1C-E1115K iPS Cell Model

  KASHIWA ASAMI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Establishment of a predictive model for GVHD-free, relapse-free survival after allogeneic HSCT using ensemble learning

  IWASAKI MAKOTO, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2023
• Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia

  TAKEDA JUNE, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes

  KOHJITANI HIROHIKO, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• APOBEC3B is preferentially expressed at the G2/M phase of cell cycle.

  HIRABAYASHI SHIGEKI, Graduate School of Medicine, Sub-chief Examiner

  24 May 2021
• Rocuronium Has a Suppressive Effect on Platelet Function via the P2Y12 Receptor Pathway In Vitro That Is Not Reversed by Sugammadex

  MURATA YUTAKA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification

  MATSUO SHIORI, Graduate School of Medicine, Sub-chief Examiner

  24 Sep. 2021
• MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains

  AKIFUJI CHIAKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Generation of monkey iPS cell-derived cartilage lacking MHC class I molecules on the cell surface

  OKUTANI YUKI, Graduate School of Medicine, Sub-chief Examiner

  24 Jan. 2022
• Identification of the Minimum Requirements for Successful Haematopoietic Stem Cell Transplantation

  NISHI KATSUYUKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency

  MU ANFENG, Graduate School of Medicine, Sub-chief Examiner

  24 May 2021
• Azacitidine is a potential therapeutic drug for pyridoxine-refractory female X-linked sideroblastic anemia

  OMUNE　YUKI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived　erythropoietin-producing cells

  KATAGIRI NAOKO, Graduate School of Medicine, Sub-chief Examiner

  24 Sep. 2021
• Identification of CXCL12-abundant reticular cells in human adult bone marrow

  AOKI KAZUNARI, Graduate School of Medicine, Sub-chief Examiner

  24 Sep. 2021
• A portable platform for stepwise hematopoiesis from human pluripotent stem cells within PET-reinforced collagen sponges

  SUGIMINE YOSHINORI, Graduate School of Medicine, Sub-chief Examiner

  24 Jan. 2022

Administration

Faculty management (title, position)

• From 01 Apr. 2024

  iPS細胞研究所 副所長
• From 01 Apr. 2024

  教員業績評価委員会
• 管理運営委員会2号委員
• From 01 Apr. 2022

  自己点検・評価委員会
• From 01 Apr. 2016, To 31 Mar. 2018

  副所長
• 共通機器管理運営委員会1号委員
• From 01 Apr. 2015, To 31 Mar. 2016

  発明委員会1号委員、委員長
• 利益相反審査委員会2号委員
• 教員表彰選考委員会2号委員
• From 01 Apr. 2020, To 31 Mar. 2024

  発明委員会1号委員
• From 01 Apr. 2020, To 31 Mar. 2022

  情報管理室長
• From 01 Apr. 2020, To 31 Mar. 2024

  情報管理委員会2.3号委員
• From 01 Apr. 2018

  ERES/CSV委員会6号委員