Basic Information

Affiliated programs (koza)

• Graduate School of Pharmaceutical Sciences, 生体分子薬学, 教授

Concurrent Affiliation

• Open Innovation Institute, 研究代表者

Professional Memberships

• PROTEIN SCIENCE SOCIETY OF JAPAN
• THE JAPANESE SOCIETY FOR VIROLOGY

Academic Degree

• 修士（医科学）(九州大学)
• 博士（医学）(九州大学)

Research History

• From Apr. 2022, To Present

  Kyoto University, Institute for Frontier Life and Medical Sciences, Professor
• From Sep. 2020, To Mar. 2022

  Kyoto University, Institute for Frontier Life and Medical Sciences, Professor
• From Apr. 2016, To Aug. 2020

  Kyushu University, Department of Virology, Faculty of medicine, Associate professor
• From Apr. 2013, To Mar. 2016

  Kyushu University, Department of Virology, Faculty of medicine, Assistant professor
• From Apr. 2012, To Mar. 2013

  The Scripps Research Institute, Dept of Immunology and Microbiology, Research associate
• From Apr. 2010, To Apr. 2012

  The Scripps Research Institute, Dept of Immunology and Microbiology, Research associate
• From Apr. 2008, To Mar. 2010

  Kyushu University, Faculty of Medical Sciences, ポスドク（日本学術振興会 特別研究員(PD)）

ID,URL

• J-Global ID

  201801004259394639

researchmap URL

• https://researchmap.jp/virology_structure

Research

Research Topics, Overview of the research

• Research Topics

  1. elucidation of viral pathogenesis
  2. development of prevention and therapeutics for viral diseases

• Overview of the research

  Infectious diseases still have been a fatal threat to children, worldwide. To solve the problem, we have been studying on pediatric virology. In particular, we focus on the mechanisms of viral entry into cells and the inhibition of entry by compounds, peptides, glycans, and antibodies, using a combination of virological and structural biological approaches. Our major goals are the elucidation of viral pathogenesis and the development of preventive and therapeutic methods for viral diseases.

Research Interests

• 膜融合
• 創薬
• 抗体
• 受容体
• 糖蛋白質
• 感染症
• 構造生物学
• ウイルス学

Research Areas

• Life sciences, Virology
• Life sciences, Structural biochemistry
• Life sciences, Pharmaceuticals - chemistry and drug development, 分子設計

Papers

• Molecular and structural insights into SARS-CoV-2 evolution: from BA.2 to XBB subvariants.

  Hisano Yajima; Tomo Nomai; Kaho Okumura; Katsumi Maenaka; Jumpei Ito; Takao Hashiguchi; Kei Sato

  mBio, 16 Sep. 2024

  
• Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination.

  Hideo Fukuhara; Kohei Yumoto; Miyuki Sako; Mizuho Kajikawa; Toyoyuki Ose; Mihiro Kawamura; Mei Yoda; Surui Chen; Yuri Ito; Shin Takeda; Mwila Mwaba; Jiaqi Wang; Takao Hashiguchi; Jun Kamishikiryo; Nobuo Maita; Chihiro Kitatsuji; Makoto Takeda; Kimiko Kuroki; Katsumi Maenaka

  eLife, 24 Jul. 2024

  
• Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

  Shuhei Tsujino; Sayaka Deguchi; Tomo Nomai; Miguel Padilla-Blanco; Arnon Plianchaisuk; Lei Wang; MST Monira Begum; Keiya Uriu; Keita Mizuma; Naganori Nao; Isshu Kojima; Tomoya Tsubo; Jingshu Li; Yasufumi Matsumura; Miki Nagao; Yoshitaka Oda; Masumi Tsuda; Yuki Anraku; Shunsuke Kita; Hisano Yajima; Kaori Sasaki-Tabata; Ziyi Guo; Alfredo A. Hinay; Kumiko Yoshimatsu; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Hesham Nasser; Michael Jonathan; Olivia Putri; Yoonjin Kim; Luo Chen; Rigel Suzuki; Tomokazu Tamura; Katsumi Maenaka; Takashi Irie; Keita Matsuno; Shinya Tanaka; Jumpei Ito; Terumasa Ikeda; Kazuo Takayama; Jiri Zahradnik; Takao Hashiguchi; Takasuke Fukuhara; Kei Sato

  Microbiology and Immunology, 2024

  
• A triggering structure of SARS-CoV-2 BA.2.86 spike upon ACE2 binding for receptor-binding domain up

  Takao Hashiguchi; Hisano Yajima; Yuki Anraku; Yu Kaku; Kanako Kimura; Arnon Plianchaisuk; Kaho Okumura; Yoshiko Nakada-Nakura; Shunsuke Kita; Jiei Sasaki; Hiromi Sumita; Jumpei Ito; Katsumi Maenaka; Kei Sato

  22 Mar. 2024

  
• Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice.

  Tomoyuki Homma; Noriyo Nagata; Masayuki Hashimoto; Naoko Iwata-Yoshikawa; Naomi M Seki; Nozomi Shiwa-Sudo; Akira Ainai; Keiji Dohi; Eiji Nikaido; Akiko Mukai; Yuuta Ukai; Takayuki Nakagawa; Yusuke Shimo; Hiroki Maeda; Seiki Shirai; Miwa Aoki; Takuhiro Sonoyama; Mamoru Sato; Masataka Fumoto; Morio Nagira; Fumihisa Nakata; Takao Hashiguchi; Tadaki Suzuki; Shinya Omoto; Hideki Hasegawa

  Scientific reports, 31 Jan. 2024

  
• Structural delineation of SARS-CoV-2 broadly neutralizing antibody to Omicron subvariants including BA.4/BA.5 and BA.2.75

  Saya Moriyama; Yuki Anraku; Shunta Taminishi; Yu Adachi; Daisuke Kuroda; Shunsuke Kita; Yusuke Higuchi; Ryutaro Kotaki; Keisuke Tonouchi; Kohei Yumoto; Tateki Suzuki; Taiyou Someya; Hideo Fukuhara; Yudai Kuroda; Tsukasa Yamamoto; Taishi Onodera; Shuetsu Fukushi; Ken Maeda; Fukumi Nakamura-Uchiyama; Takao Hashiguchi; Atsushi Hoshino; Katsumi Maenaka; Yoshimasa Takahashi

  21 Dec. 2022

  
• Unveiling the affinity–stability relationship in anti-measles virus antibodies: a computational approach for hotspots prediction

  Rimpa Paul; Keisuke Kasahara; Jiei Sasaki; Jorge Fernández Pérez; Ryo Matsunaga; Takao Hashiguchi; Daisuke Kuroda; Kouhei Tsumoto

  Frontiers in Molecular Biosciences, 01 Mar. 2024

  
• SARS-CoV-2始祖株とオミクロンBA.5の比較による有用ワクチン抗原設計指針の探索

  逸見 拓矢; 石川 青空; 矢島 久乃; 佐々木 慈英; 杉田 征彦; 相内 章; 野田 岳志; 鈴木 忠樹; 橋口 隆生

  臨床とウイルス, Sep. 2023

  
• Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.

  Tomokazu Tamura; Takashi Irie; Sayaka Deguchi; Hisano Yajima; Masumi Tsuda; Hesham Nasser; Keita Mizuma; Arnon Plianchaisuk; Saori Suzuki; Keiya Uriu; Mst Monira Begum; Ryo Shimizu; Michael Jonathan; Rigel Suzuki; Takashi Kondo; Hayato Ito; Akifumi Kamiyama; Kumiko Yoshimatsu; Maya Shofa; Rina Hashimoto; Yuki Anraku; Kanako Terakado Kimura; Shunsuke Kita; Jiei Sasaki; Kaori Sasaki-Tabata; Katsumi Maenaka; Naganori Nao; Lei Wang; Yoshitaka Oda; Terumasa Ikeda; Akatsuki Saito; Keita Matsuno; Jumpei Ito; Shinya Tanaka; Kei Sato; Takao Hashiguchi; Kazuo Takayama; Takasuke Fukuhara

  Nature communications, 08 Feb. 2024

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• Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1

  Tatsuhiko Ozawa; Yoshiki Ikeda; Liuan Chen; Rigel Suzuki; Atsushi Hoshino; Akira Noguchi; Shunsuke Kita; Yuki Anraku; Emiko Igarashi; Yumiko Saga; Noriko Inasaki; Shunta Taminishi; Jiei Sasaki; Yuhei Kirita; Hideo Fukuhara; Katsumi Maenaka; Takao Hashiguchi; Takasuke Fukuhara; Kenichi Hirabayashi; Hideki Tani; Hiroyuki Kishi; Hideki Niimi

  Structure, Jan. 2024

  
• Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.

  Izumi Kimura; Daichi Yamasoba; Hesham Nasser; Hayato Ito; Jiri Zahradnik; Jiaqi Wu; Shigeru Fujita; Keiya Uriu; Jiei Sasaki; Tomokazu Tamura; Rigel Suzuki; Sayaka Deguchi; Arnon Plianchaisuk; Kumiko Yoshimatsu; Yasuhiro Kazuma; Shuya Mitoma; Gideon Schreiber; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Akifumi Takaori-Kondo; Jumpei Ito; Kotaro Shirakawa; Kazuo Takayama; Takashi Irie; Takao Hashiguchi; So Nakagawa; Takasuke Fukuhara; Akatsuki Saito; Terumasa Ikeda; Kei Sato

  Journal of virology, 05 Oct. 2023, Peer-reviewed

  
• Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells.

  Kousuke Yonemoto; Fumihiko Fujii; Ryoji Taira; Masahiro Ohgidani; Katsuhide Eguchi; Sayaka Okuzono; Yuko Ichimiya; Yuri Sonoda; Pin Fee Chong; Hironori Goto; Hikaru Kanemasa; Yoshitomo Motomura; Masataka Ishimura; Yuhki Koga; Keita Tsujimura; Takao Hashiguchi; Hiroyuki Torisu; Ryutaro Kira; Takahiro A Kato; Yasunari Sakai; Shouichi Ohga

  Clinical immunology (Orlando, Fla.), Oct. 2023

  
• Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope

  Keisuke Tonouchi; Yu Adachi; Tateki Suzuki; Daisuke Kuroda; Ayae Nishiyama; Kohei Yumoto; Haruko Takeyama; Tadaki Suzuki; Takao Hashiguchi; Yoshimasa Takahashi

  PLOS Pathogens, 09 Aug. 2023

  
• Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants.

  Saya Moriyama; Yuki Anraku; Shunta Taminishi; Yu Adachi; Daisuke Kuroda; Shunsuke Kita; Yusuke Higuchi; Yuhei Kirita; Ryutaro Kotaki; Keisuke Tonouchi; Kohei Yumoto; Tateki Suzuki; Taiyou Someya; Hideo Fukuhara; Yudai Kuroda; Tsukasa Yamamoto; Taishi Onodera; Shuetsu Fukushi; Ken Maeda; Fukumi Nakamura-Uchiyama; Takao Hashiguchi; Atsushi Hoshino; Katsumi Maenaka; Yoshimasa Takahashi

  Nature communications, 14 Jul. 2023

  
• Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants.

  Tomokazu Tamura; Jumpei Ito; Keiya Uriu; Jiri Zahradnik; Izumi Kida; Yuki Anraku; Hesham Nasser; Maya Shofa; Yoshitaka Oda; Spyros Lytras; Naganori Nao; Yukari Itakura; Sayaka Deguchi; Rigel Suzuki; Lei Wang; Mst Monira Begum; Shunsuke Kita; Hisano Yajima; Jiei Sasaki; Kaori Sasaki-Tabata; Ryo Shimizu; Masumi Tsuda; Yusuke Kosugi; Shigeru Fujita; Lin Pan; Daniel Sauter; Kumiko Yoshimatsu; Saori Suzuki; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yuki Yamamoto; Tetsuharu Nagamoto; Gideon Schreiber; Katsumi Maenaka; Takao Hashiguchi; Terumasa Ikeda; Takasuke Fukuhara; Akatsuki Saito; Shinya Tanaka; Keita Matsuno; Kazuo Takayama; Kei Sato

  Nature communications, 16 May 2023

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• Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant.

  Jumpei Ito; Rigel Suzuki; Keiya Uriu; Yukari Itakura; Jiri Zahradnik; Kanako Terakado Kimura; Sayaka Deguchi; Lei Wang; Spyros Lytras; Tomokazu Tamura; Izumi Kida; Hesham Nasser; Maya Shofa; Mst Monira Begum; Masumi Tsuda; Yoshitaka Oda; Tateki Suzuki; Jiei Sasaki; Kaori Sasaki-Tabata; Shigeru Fujita; Kumiko Yoshimatsu; Hayato Ito; Naganori Nao; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yuki Yamamoto; Tetsuharu Nagamoto; Jin Kuramochi; Gideon Schreiber; Akatsuki Saito; Keita Matsuno; Kazuo Takayama; Takao Hashiguchi; Shinya Tanaka; Takasuke Fukuhara; Terumasa Ikeda; Kei Sato

  Nature communications, 11 May 2023

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• Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus.

  Satoshi Ikegame; Jillian C Carmichael; Heather Wells; Robert L Furler O'Brien; Joshua A Acklin; Hsin-Ping Chiu; Kasopefoluwa Y Oguntuyo; Robert M Cox; Aum R Patel; Shreyas Kowdle; Christian S Stevens; Miles Eckley; Shijun Zhan; Jean K Lim; Ethan C Veit; Matthew J Evans; Takao Hashiguchi; Edison Durigon; Tony Schountz; Jonathan H Epstein; Richard K Plemper; Peter Daszak; Simon J Anthony; Benhur Lee

  Nature microbiology, 04 May 2023

  
• Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein

  Ryuichi Takemoto; Yuichi Hirai; Shumpei Watanabe; Hidetaka Harada; Tateki Suzuki; Takao Hashiguchi; Yusuke Yanagi; Yuta Shirogane

  Journal of Virology, May 2023, Peer-reviewed

  
• Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants.

  Kiyomi Shitaoka; Akifumi Higashiura; Yohei Kawano; Akima Yamamoto; Yoko Mizoguchi; Takao Hashiguchi; Norihisa Nishimichi; Shiyu Huang; Ayano Ito; Shun Ohki; Miyuki Kanda; Tomohiro Taniguchi; Rin Yoshizato; Hitoshi Azuma; Yasuo Kitajima; Yasuyuki Yokosaki; Satoshi Okada; Takemasa Sakaguchi; Tomoharu Yasuda

  Communications biology, 11 Apr. 2023

  
• Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice.

  Tomoyuki Homma; Noriyo Nagata; Masayuki Hashimoto; Naoko Iwata-Yoshikawa; Naomi M Seki; Nozomi Shiwa-Sudo; Akira Ainai; Keiji Dohi; Eiji Nikaido; Akiko Mukai; Yuuta Ukai; Takayuki Nakagawa; Yusuke Shimo; Hiroki Maeda; Seiki Shirai; Miwa Aoki; Takuhiro Sonoyama; Mamoru Sato; Masataka Fumoto; Morio Nagira; Fumihisa Nakata; Takao Hashiguchi; Tadaki Suzuki; Shinya Omoto; Hideki Hasegawa

  Scientific reports, 02 Dec. 2022

  
• Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.

  Akatsuki Saito; Tomokazu Tamura; Jiri Zahradnik; Sayaka Deguchi; Koshiro Tabata; Yuki Anraku; Izumi Kimura; Jumpei Ito; Daichi Yamasoba; Hesham Nasser; Mako Toyoda; Kayoko Nagata; Keiya Uriu; Yusuke Kosugi; Shigeru Fujita; Maya Shofa; Mst Monira Begum; Ryo Shimizu; Yoshitaka Oda; Rigel Suzuki; Hayato Ito; Naganori Nao; Lei Wang; Masumi Tsuda; Kumiko Yoshimatsu; Jin Kuramochi; Shunsuke Kita; Kaori Sasaki-Tabata; Hideo Fukuhara; Katsumi Maenaka; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Takamasa Ueno; Gideon Schreiber; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hirofumi Sawa; Takashi Irie; Takao Hashiguchi; Kazuo Takayama; Keita Matsuno; Shinya Tanaka; Terumasa Ikeda; Takasuke Fukuhara; Kei Sato

  Cell host & microbe, 09 Nov. 2022

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• Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5.

  Izumi Kimura; Daichi Yamasoba; Tomokazu Tamura; Naganori Nao; Tateki Suzuki; Yoshitaka Oda; Shuya Mitoma; Jumpei Ito; Hesham Nasser; Jiri Zahradnik; Keiya Uriu; Shigeru Fujita; Yusuke Kosugi; Lei Wang; Masumi Tsuda; Mai Kishimoto; Hayato Ito; Rigel Suzuki; Ryo Shimizu; Mst Monira Begum; Kumiko Yoshimatsu; Kanako Terakado Kimura; Jiei Sasaki; Kaori Sasaki-Tabata; Yuki Yamamoto; Tetsuharu Nagamoto; Jun Kanamune; Kouji Kobiyama; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Kotaro Shirakawa; Akifumi Takaori-Kondo; Jin Kuramochi; Gideon Schreiber; Ken J Ishii; Takao Hashiguchi; Terumasa Ikeda; Akatsuki Saito; Takasuke Fukuhara; Shinya Tanaka; Keita Matsuno; Kei Sato

  Cell, 13 Oct. 2022

  
• Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants.

  Tatsuhiko Ozawa; Hideki Tani; Yuki Anraku; Shunsuke Kita; Emiko Igarashi; Yumiko Saga; Noriko Inasaki; Hitoshi Kawasuji; Hiroshi Yamada; So-Ichiro Sasaki; Mayu Somekawa; Jiei Sasaki; Yoshihiro Hayakawa; Yoshihiro Yamamoto; Yoshitomo Morinaga; Nobuyuki Kurosawa; Masaharu Isobe; Hideo Fukuhara; Katsumi Maenaka; Takao Hashiguchi; Hiroyuki Kishi; Isao Kitajima; Shigeru Saito; Hideki Niimi

  mAbs, 2022

  
• Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus.

  Yuta Shirogane; Hidetaka Harada; Yuichi Hirai; Ryuichi Takemoto; Tateki Suzuki; Takao Hashiguchi; Yusuke Yanagi

  Science advances, 27 Jan. 2023

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• Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology.

  Takuya Hemmi; Akira Ainai; Takao Hashiguchi; Minoru Tobiume; Takayuki Kanno; Naoko Iwata-Yoshikawa; Shun Iida; Yuko Sato; Sho Miyamoto; Akira Ueno; Kaori Sano; Shinji Saito; Nozomi Shiwa-Sudo; Noriyo Nagata; Koji Tamura; Ryosuke Suzuki; Hideki Hasegawa; Tadaki Suzuki

  Vaccine, 26 Aug. 2022

  
• Application of Acoustic Ejection MS System to High-Throughput Screening for SARS-CoV-2 3CL Protease Inhibitors.

  Tsukasa Hasegawa; Riyo M Imamura; Tateki Suzuki; Takao Hashiguchi; Takao Nomura; Satoko Otsuguro; Katsumi Maenaka; Michihito Sasaki; Yasuko Orba; Hirofumi Sawa; Akihiko Sato; Takayoshi Okabe; Tetsuo Nagano; Hirotatsu Kojima

  Chemical & pharmaceutical bulletin, 01 Mar. 2022

  
• Preparation of glycopolymers having sialyl α2 → 3 lactose moieties as the potent inhibitors for mumps virus.

  Koji Matsuoka; Takayuki Kaneshima; Ryota Adachi; Jiei Sasaki; Takao Hashiguchi; Tetsuo Koyama; Takahiko Matsushita; Ken Hatano

  Bioorganic & medicinal chemistry letters, 15 Nov. 2021

  
• Unique Tropism and Entry Mechanism of Mumps Virus.

  Marie Kubota; Takao Hashiguchi

  Viruses, 01 Sep. 2021

  
• Characterization of Natural and Synthetic Sialoglycans Targeting the Hemagglutinin-Neuraminidase of Mumps Virus.

  Rosa Ester Forgione; Cristina Di Carluccio; Francesco Milanesi; Marie Kubota; Ferran Fabregat Nieto; Antonio Molinaro; Takao Hashiguchi; Oscar Francesconi; Roberta Marchetti; Alba Silipo

  Frontiers in chemistry, 2021

  
• 【ウイルス感染症に取り組む生物物理学】ウイルス生物物理学 創薬モダリティへの貢献

  前仲 勝実; 福原 秀雄; 橋口 隆生; Caaveiro Jose M.M.; 長門石 曉; 黒田 大祐; 津本 浩平

  生物物理, Mar. 2021

  
• Short-Stalk Isoforms of CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Interacting with the Viral Hemagglutinin

  Ryuichi Takemoto; Tateki Suzuki; Takao Hashiguchi; Yusuke Yanagi; Yuta Shirogane

  Journal of Virology, 09 Feb. 2022

  
• A SARS-CoV-2 Antibody Broadly Neutralizes SARS-related Coronaviruses and Variants by Coordinated Recognition of a Virus Vulnerable Site

  Taishi Onodera; Shunsuke Kita; Yu Adachi; Saya Moriyama; Akihiko Sato; Takao Nomura; Shuhei Sakakibara; Takeshi Inoue; Takashi Tadokoro; Yuki Anraku; Kohei Yumoto; Cong Tian; Hideo Fukuhara; Michihito Sasaki; Yasuko Orba; Nozomi Shiwa; Naoko Iwata; Noriyo Nagata; Tateki Suzuki; Jiei Sasaki; Tsuyoshi Sekizuka; Keisuke Tonouchi; Lin Sun; Shuetsu Fukushi; Hiroyuki Satofuka; Yasuhiro Kazuki; Mitsuo Oshimura; Tomohiro Kurosaki; Makoto Kuroda; Yoshiharu Matsuura; Tadaki Suzuki; Hirofumi Sawa; Takao Hashiguchi; Katsumi Maenaka; Yoshimasa Takahashi

  Immunity, Aug. 2021

  
• Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19.

  Yu Kaku; Takeo Kuwata; Hasan Md Zahid; Takao Hashiguchi; Takeshi Noda; Noriko Kuramoto; Shashwata Biswas; Kaho Matsumoto; Mikiko Shimizu; Yoko Kawanami; Kazuya Shimura; Chiho Onishi; Yukiko Muramoto; Tateki Suzuki; Jiei Sasaki; Yoji Nagasaki; Rumi Minami; Chihiro Motozono; Mako Toyoda; Hiroshi Takahashi; Hiroto Kishi; Kazuhiko Fujii; Tsuneyuki Tatsuke; Terumasa Ikeda; Yosuke Maeda; Takamasa Ueno; Yoshio Koyanagi; Hajime Iwagoe; Shuzo Matsushita

  Cell reports, 25 Jun. 2021

  
• CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis.

  Yuta Shirogane; Ryuichi Takemoto; Tateki Suzuki; Tomonori Kameda; Kinichi Nakashima; Takao Hashiguchi; Yusuke Yanagi

  Journal of virology, 24 Jun. 2021

  
• The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection

  Yuriko Tomita; Shutoku Matsuyama; Hideo Fukuhara; Katsumi Maenaka; Hiroaki Kataoka; Takao Hashiguchi; Makoto Takeda

  JOURNAL OF VIROLOGY, Jun. 2021

  
• Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes

  Satoshi Ikegame; Takao Hashiguchi; Chuan-Tien Hung; Kristina Dobrindt; Kristen J. Brennand; Makoto Takeda; Benhur Lee

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2021

  
• Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

  Hirofumi Ohashi; Koichi Watashi; Wakana Saso; Kaho Shionoya; Shoya Iwanami; Takatsugu Hirokawa; Tsuyoshi Shirai; Shigehiko Kanaya; Yusuke Ito; Kwang Su Kim; Takao Nomura; Tateki Suzuki; Kazane Nishioka; Shuji Ando; Keisuke Ejima; Yoshiki Koizumi; Tomohiro Tanaka; Shin Aoki; Kouji Kuramochi; Tadaki Suzuki; Takao Hashiguchi; Katsumi Maenaka; Tetsuro Matano; Masamichi Muramatsu; Masayuki Saijo; Kazuyuki Aihara; Shingo Iwami; Makoto Takeda; Jane A. McKeating; Takaji Wakita

  ISCIENCE, Apr. 2021

  
• Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein.

  Ayako Ueo; Marie Kubota; Yuta Shirogane; Shinji Ohno; Takao Hashiguchi; Yusuke Yanagi

  Journal of virology, 01 Jun. 2020, Peer-reviewed

  
• Structural basis for Glycan-receptor binding by mumps virus hemagglutinin-neuraminidase.

  Rosa Ester Forgione; Cristina Di Carluccio; Marie Kubota; Yoshiyuki Manabe; Koichi Fukase; Antonio Molinaro; Takao Hashiguchi; Roberta Marchetti; Alba Silipo

  Scientific reports, 31 Jan. 2020, Peer-reviewed

  
• Weak cis and trans Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates.

  Yuta Shirogane; Takao Hashiguchi; Yusuke Yanagi

  Journal of virology, 06 Jan. 2020, Peer-reviewed

  
• Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering.

  Marie Kubota; Iori Okabe; Shin-Ichi Nakakita; Ayako Ueo; Yuta Shirogane; Yusuke Yanagi; Takao Hashiguchi

  Journal of virology, 06 Jan. 2020, Peer-reviewed

  
• Large-Scale Expression and Purification of Mumps Virus Hemagglutinin-Neuraminidase for Structural Analyses and Glycan-Binding Assays.

  Marie Kubota; Takao Hashiguchi

  Methods in molecular biology (Clifton, N.J.), 2020, Peer-reviewed

  
• Biophysical characterization and single-chain Fv construction of a neutralizing antibody to measles virus.

  Takashi Tadokoro; Mst Lubna Jahan; Yuri Ito; Maino Tahara; Surui Chen; Atsutoshi Imai; Natsumi Sugimura; Koki Yoshida; Mizuki Saito; Toyoyuki Ose; Takao Hashiguchi; Makoto Takeda; Hideo Fukuhara; Katsumi Maenaka

  The FEBS journal, Jan. 2020, Peer-reviewed

  
• Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species.

  Hideo Fukuhara; Yuri Ito; Miyuki Sako; Mizuho Kajikawa; Koki Yoshida; Fumio Seki; Mwila Hilton Mwaba; Takao Hashiguchi; Masa-Aki Higashibata; Toyoyuki Ose; Kimiko Kuroki; Makoto Takeda; Katsumi Maenaka

  Viruses, 19 Aug. 2019, Peer-reviewed

  
• Molecular mechanism of the flexible glycan-receptor recognition by mumps virus.

  Kubota M; Matsuoka R; Suzuki T; Yonekura K; Yanagi Y; Hashiguchi T

  Journal of virology, May 2019, Peer-reviewed

  
• New Insights into Measles Virus Brain Infections.

  Shumpei Watanabe; Yuta Shirogane; Yuma Sato; Takao Hashiguchi; Yusuke Yanagi

  Trends in microbiology, Feb. 2019, Peer-reviewed

  
• Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route.

  Mathieu C; Ferren M; Jurgens E; Dumont C; Rybkina K; Harder O; Stelitano D; Madeddu S; Sanna G; Schwartz D; Biswas S; Hardie D; Hashiguchi T; Moscona A; Horvat B; Niewiesk S; Porotto M

  Journal of virology, Feb. 2019, Peer-reviewed

  
• Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain.

  Angius F; Smuts H; Rybkina K; Stelitano D; Eley B; Wilmshurst J; Ferren M; Lalande A; Mathieu C; Moscona A; Horvat B; Hashiguchi T; Porotto M; Hardie D

  Journal of virology, Nov. 2018, Peer-reviewed

  
• Structures of the prefusion form of measles virus fusion protein in complex with inhibitors.

  Takao Hashiguchi; Yoshinari Fukuda; Rei Matsuoka; Daisuke Kuroda; Marie Kubota; Yuta Shirogane; Shumpei Watanabe; Kouhei Tsumoto; Daisuke Kohda; Richard Karl Plemper; Yusuke Yanagi

  Proceedings of the National Academy of Sciences of the United States of America, 06 Mar. 2018, Peer-reviewed

  
• Cell-to-cell measles virus spread between human neurons is dependent on hemagglutinin and hyperfusogenic fusion protein

  Yuma Sato; Shumpei Watanabe; Yoshinari Fukuda; Takao Hashiguchi; Yusuke Yanagi; Shinji Ohno

  Journal of Virology, 01 Mar. 2018, Peer-reviewed

  
• Annexin A2 Mediates the Localization of Measles Virus Matrix Protein at the Plasma Membrane.

  Koga R; Kubota M; Hashiguchi T; Yanagi Y; Ohno S

  Journal of virology, Feb. 2018, Peer-reviewed

  
• Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein

  Amandeep K. Sangha; Jinhui Dong; Lauren Williamson; Takao Hashiguchi; Erica Ollmann Saphire; James E. Crowe; Jens Meiler

  STRUCTURE, Dec. 2017, Peer-reviewed

  
• Trisaccharide containing alpha 2,3-linked sialic acid is a receptor for mumps virus

  Marie Kubota; Kaoru Takeuchi; Shumpei Watanabe; Shinji Ohno; Rei Matsuoka; Daisuke Kohda; Shin-ichi Nakakita; Hiroaki Hiramatsu; Yasuo Suzuki; Tetsuo Nakayama; Tohru Terada; Kentaro Shimizu; Nobutaka Shimizu; Mitsunori Shiroishi; Yusuke Yanagi; Takao Hashiguchi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2016, Peer-reviewed

  
• Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs

  Marnie L. Fusco; Takao Hashiguchi; Robyn Cassan; Julia E. Biggins; Charles D. Murin; Kelly L. Warfield; Sheng Li; Frederick W. Holtsberg; Sergey Shulenin; Hong Vu; Gene G. Olinger; Do H. Kim; Kevin J. Whaley; Larry Zeitlin; Andrew B. Ward; Cory Nykiforuk; M. Javad Aman; Jody Berry; Erica Ollmann Saphire

  PLOS PATHOGENS, Jun. 2015, Peer-reviewed

  
• Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus

  Andrew I. Flyak; Philipp A. Ilinykh; Charles D. Murin; Tania Garron; Xiaoli Shen; Marnie L. Fusco; Takao Hashiguchi; Zachary A. Bornholdt; James C. Slaughter; Gopal Sapparapu; Curtis Klages; Thomas G. Ksiazek; Andrew B. Ward; Erica Ollmann Saphire; Alexander Bukreyev; James E. Crowe

  CELL, Feb. 2015, Peer-reviewed

  
• Structural Basis for Marburg Virus Neutralization by a Cross-Reactive Human Antibody

  Takao Hashiguchi; Marnie L. Fusco; Zachary A. Bornholdt; Jeffrey E. Lee; Andrew I. Flyak; Rei Matsuoka; Daisuke Kohda; Yusuke Yanagi; Michal Hammel; James E. Crowe; Erica Ollmann Saphire

  CELL, Feb. 2015, Peer-reviewed

  
• Mutations in the putative dimer-dimer interfaces of the measles virus hemagglutinin head domain affect membrane fusion triggering.

  Mai Nakashima; Yuta Shirogane; Takao Hashiguchi; Yusuke Yanagi

  The Journal of biological chemistry, 22 Mar. 2013, Peer-reviewed

  
• Crystallization Strategy for the Glycoprotein-Receptor Complex Between Measles Virus Hemagglutinin and Its Cellular Receptor SLAM

  Takao Hashiguchi; Toyoyuki Ose; Marie Kubota; Nobuo Maita; Jun Kamishikiryo; Katsumi Maenaka; Yusuke Yanagi

  PROTEIN AND PEPTIDE LETTERS, Apr. 2012, Peer-reviewed

  
• Structural Basis for Differential Neutralization of Ebolaviruses

  Shridhar Bale; Joao M. Dias; Marnie L. Fusco; Takao Hashiguchi; Anthony C. Wong; Tong Liu; Ana I. Keuhne; Sheng Li; Virgil L. Woods; Kartik Chandran; John M. Dye; Erica Ollmann Saphire

  VIRUSES-BASEL, Apr. 2012, Peer-reviewed

  
• Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus

  Daniel Olal; Ana I. Kuehne; Shridhar Bale; Peter Halfmann; Takao Hashiguchi; Marnie L. Fusco; Jeffrey E. Lee; Liam B. King; Yoshihiro Kawaoka; John M. Dye; Erica Ollmann Saphire

  JOURNAL OF VIROLOGY, Mar. 2012, Peer-reviewed

  
• [Structural basis for measles virus-receptor recognition and its functional implications for viral entry and vaccination].

  Maenaka K; Hashiguchi T; Yanagi Y

  Nihon rinsho. Japanese journal of clinical medicine, 2012, Peer-reviewed

  
• Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM

  Takao Hashiguchi; Toyoyuki Ose; Marie Kubota; Nobuo Maita; Jun Kamishikiryo; Katsumi Maenaka; Yusuke Yanagi

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Feb. 2011, Peer-reviewed

  
• Measles virus hemagglutinin: structural insights into cell entry and measles vaccine

  Takao Hashiguchi; Katsumi Maenaka; Yusuke Yanagi

  FRONTIERS IN MICROBIOLOGY, 2011, Peer-reviewed

  
• Measles Virus Receptors

  Y. Yanagi; M. Takeda; S. Ohno; T. Hashiguchi

  MEASLES: HISTORY AND BASIC BIOLOGY, 2009, Peer-reviewed

  
• Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin

  Maino Tahara; Makoto Takeda; Yuta Shirogane; Takao Hashiguchi; Shinji Ohno; Yusuke Yanagi

  JOURNAL OF VIROLOGY, May 2008, Peer-reviewed

  
• Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150)

  Chanakha K. Navaratnarajah; Sompong Vongpunsawad; Numan Oezguen; Thilo Stehle; Werner Braun; Takao Hashiguchi; Katsumi Maenaka; Yusuke Yanagi; Roberto Cattaneo

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2008, Peer-reviewed

  
• Homogeneous sugar modification improves crystallization of measles virus hemagglutinin

  Takao Hashiguchi; Mizuho Kajikawa; Maita Nobuo; Makoto Takeda; Kimiko Kuroki; Kaori Sasaki; Daisuke Kohda; Yusuke Yanagi; Katsumi Maenaka

  JOURNAL OF VIROLOGICAL METHODS, Apr. 2008, Peer-reviewed

  
• Crystal structure of measles virus hemagglutinin provides insight into effective vaccines

  Takao Hashiguchi; Mizuho Kajikawa; Nobuo Maita; Makoto Takeda; Kimiko Kuroki; Kaori Sasaki; Daisuke Kohda; Yusuke Yanagi; Katsumi Maenaka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2007, Peer-reviewed

  
• A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-Independent mechanism

  Makoto Takeda; Maino Tahara; Takao Hashiguchi; Takeshi A. Sato; Fumiaki Jinnouchi; Shoko Ueki; Shinji Ohno; Yusuke Yanagi

  JOURNAL OF VIROLOGY, Nov. 2007, Peer-reviewed

  
• Multiple amino acid substitutions in hemagglutinin are necessary for wild-type measles virus to acquire the ability to use receptor CD46 efficiently

  Maino Tahara; Makoto Takeda; Fumio Seki; Takao Hashiguchi; Yusuke Yanagi

  JOURNAL OF VIROLOGY, Mar. 2007, Peer-reviewed

  
• Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells

  Ryo Kurita; Erika Sasaki; Tomoko Yokoo; Takashi Hiroyama; Kashiya Takasugi; Hideyuki Imoto; Kiyoko Izawa; Yan Dong; Takao Hashiguchi; Yasushi Soda; Toyoki Maeda; Youko Suehiro; Yoshikuni Tanioka; Yukoh Nakazaki; Kenzaburo Tani

  STEM CELLS, Sep. 2006, Peer-reviewed

  
• Generation of measles virus with a segmented RNA genome

  M Takeda; Y Nakatsu; S Ohno; F Seki; M Tahara; T Hashiguchi; Y Yanagi

  JOURNAL OF VIROLOGY, May 2006, Peer-reviewed

  

Misc.

• In silicoで改変したUT28KはSARS-CoV-2オミクロンBA.1に対して中和活性を回復した

  小澤龍彦; 小澤龍彦; 池田幸樹; CHEN Liuan; 鈴木理滋; 星野温; 野口映; 喜多俊介; 安楽佑樹; 五十嵐笑子; 佐賀由美子; 稲崎倫子; 民西俊太; 佐々木慈英; 桐田雄平; 福原秀雄; 前仲勝実; 橋口隆生; 福原崇介; 平林健一; 谷英樹; 岸裕幸; 岸裕幸; 仁井見英樹; 仁井見英樹

  日本抗体学会学術大会プログラム・抄録集(Web), 2023

  
• Mechanisms underlying central nervous system infection caused by measles virus

  佐藤裕真; 橋口隆生

  医学のあゆみ, 2024

  
• Structural Basis of Receptor Recognition and Escape from Neutralizing Antibodies by SARS-CoV-2 variants

  橋口隆生

  量子ビームサイエンスフェスタ(Web), 2023

  
• Neutralization mechanism revealed by structural analysis of SARS CoV-2 spike protein complexed with antibodies

  山本旭麻; 東浦彰史; 下岡清美; 河野洋平; 喜多俊介; 安楽佑樹; 橋口隆生; 前仲勝実; 保田朋波流; 坂口剛正

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein and its ACE2 receptor recognition mechanism and structural comparison with XBB.1

  矢島久乃; 安楽佑樹; 喜多俊介; 佐々木慈英; 木村(寺角)香菜子; 前仲勝実; 佐藤佳; 福原崇介; 橋口隆生

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• Structural analysis of SARS-CoV-2 XBB.1 spike protein and ACE2 complex

  安楽佑樹; 喜多俊介; 矢島久乃; 佐藤佳; 橋口隆生; 前仲勝実

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• Novel systems for the evaluation of drug efficacy against measles virus infection in the central nervous system

  佐藤裕真; 永樂元次; 橋口隆生

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• Structural basis for ACE2 receptor recognition and antibody escape by SARS-CoV-2 BQ.1.1 mutant S protein RBD

  木村香菜子; 鈴木干城; 佐々木慈英; 佐藤佳; 橋口隆生

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• Analysis of the relationship between neutralizing activity and antigen recognition mechanism based on the structure of NIV antibody and SARS-CoV-2 spike protein complex.

  染谷太陽; 安楽佑樹; 森山彩野; 橋口隆生; 高橋宜聖; 喜多俊介; 前仲勝実

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• X-206 exhibits broad-spectrum and robust inhibition against infections by several drug-resistant isolates and variants of SARS-CoV-2.

  佐々木慈英; 岡部伊織; 佐藤彰彦; 佐藤彰彦; 佐藤彰彦; 児玉耕太; 乙黒聡子; 佐々木道仁; 大場靖子; 澤洋文; 澤洋文; 前仲勝実; 柳雄介; 橋口隆生

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• SARS-CoV-2S protein搭載による細胞外小胞の膜融合促進

  中川優奈; 川口祥正; 橋口隆生; 二木史朗

  生体膜と薬物の相互作用シンポジウム講演要旨集, 2023

  
• SARS-CoV-2中和抗体の一本鎖Fv断片を用いた構造解析

  田所高志; 田所高志; 喜多俊介; 染谷太陽; 安楽佑樹; 福原秀雄; 福原秀雄; 野村尚生; 小野寺大志; 森山彩野; 橋口隆生; 高橋宜聖; 前仲勝実; 前仲勝実

  日本結晶学会年会講演要旨集, 2023

  
• SARS-CoV-2スパイク蛋白質と広域中和抗体の複合体構造解析

  山本旭麻; 東浦彰史; 下岡清美; 河野洋平; 喜多俊介; 安楽佑樹; 野間井智; 橋口隆生; 前仲勝実; 保田朋波流; 坂口剛正

  日本結晶学会年会講演要旨集, 2023

  
• 新型コロナウイルス変異株による受容体への親和性増強および抗体逃避の構造基盤

  橋口隆生

  日本生化学会大会(Web), 2023

  
• 新型コロナウイルスに対するスーパー中和抗体UT28Kの分子基盤

  喜多俊介; 安楽佑樹; 小澤龍彦; 谷英樹; 五十嵐笑子; 佐賀由美子; 稲崎倫子; 川筋仁史; 山田博司; 佐々木宗一郎; 染川真由; 佐々木慈英; 早川芳弘; 山本善裕; 森永芳智; 黒澤信幸; 磯部正治; 福原秀雄; 前仲勝実; 橋口隆生; 岸裕幸; 北島勲; 齋藤滋; 仁井見英樹

  日本結晶学会年会講演要旨集, 2022

  
• 経鼻COVID-19組換えタンパク質ワクチンは広域中和能をもつIgA抗体を誘導できる

  逸見拓矢; 逸見拓矢; 相内章; 相内章; 橋口隆生; 橋口隆生; 石川青空; 石川青空; 飛梅実; 菅野隆行; 岩田(吉河)奈織子; 飯田俊; 宮本翔; 上野朗; 上野朗; 佐野芳; 田村浩二; 田村浩二; 鈴木亮介; 鈴木亮介; 長谷川秀樹; 鈴木忠樹

  日本ワクチン学会学術集会プログラム・抄録集, 2022

  
• ODN2006をアジュバントとする経鼻COVID-19ワクチンは広域中和能を有するIgA抗体を誘導し,ワクチン関連呼吸器疾患増強のリスクを軽減できる

  逸見拓矢; 逸見拓矢; 相内章; 相内章; 橋口隆生; 橋口隆生; 飛梅実; 菅野隆行; 岩田(吉河)奈織子; 飯田俊; 宮本翔; 上野朗; 上野朗; 佐野芳; 齋藤慎二; 志和(須藤)希; 永田典代; 田村浩二; 鈴木亮介; 鈴木亮介; 長谷川秀樹; 鈴木忠樹

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2022

  
• 強力な中和抗体NT-108によるSARS-CoV-2スパイクタンパク質認識の構造的基盤

  安楽佑樹; 小野寺大志; 喜多俊介; 安達悠; 森山彩野; 佐藤彰彦; 佐藤彰彦; 野村尚生; 田所高志; 田所高志; 湯本航平; 湯本航平; 伊東詩織; 田聡; 福原秀雄; 福原秀雄; 佐々木道仁; 大場靖子; 志和希; 岩田奈織子; 永田典代; 鈴木干城; 佐々木慈英; 関塚剛史; 登内奎介; 福士秀悦; 里深博幸; 香月康宏; 孫琳; 押村光雄; 黒田誠; 鈴木忠樹; 澤洋文; 橋口隆生; 高橋宜聖; 前仲勝実

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2022

  
• SARS-CoV-2始祖株とオミクロンBA.5の比較による有用ワクチン抗原設計指針の探索

  逸見拓矢; 逸見拓矢; 石川青空; 石川青空; 矢島久乃; 佐々木慈英; 杉田征彦; 杉田征彦; 相内章; 相内章; 野田岳志; 鈴木忠樹; 橋口隆生

  日本ワクチン学会学術集会プログラム・抄録集, 2023

  
• Exploring useful vaccine antigens using spike proteins with different structures

  逸見拓矢; 逸見拓矢; 石川青空; 石川青空; 矢島久乃; 佐々木慈英; 杉田征彦; 杉田征彦; 相内章; 相内章; 野田岳志; 鈴木忠樹; 橋口隆生

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2023

  
• 新型コロナウイルスに対するscFv化抗体の機能評価

  染谷太陽; 谷秀顕; 安楽佑樹; 田聡; 福原秀雄; 福原秀雄; 野村尚生; 田所高志; 小野寺大志; 安達悠; 森山彩野; 湯本航平; 鈴木干城; 佐々木慈英; 橋口隆生; 高橋宜聖; 喜多俊介; 前仲勝実; 前仲勝実

  日本蛋白質科学会年会プログラム・要旨集, 2023

  
• N460K変異を有するSARS-CoV-2BA.2.75スパイクタンパク質のACE2親和性に関する構造的洞察

  安楽佑樹; 喜多俊介; 福原秀雄; 福原秀雄; 佐藤佳; 橋口隆生; 前仲勝実; 前仲勝実

  日本蛋白質科学会年会プログラム・要旨集, 2023

  
• 汎SARS-CoV-2抗体の中和機構とBA.4/5変異株によるACE2受容体認識機構の構造基盤

  鈴木干城; 安楽佑樹; 木村香菜子; 喜多俊介; 佐々木慈英; 小澤龍彦; 仁井見英樹; 佐藤佳; 前仲勝実; 橋口隆生

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2022

  
• X-ray crystal structure analysis of SARS-CoV-2 spike protein and neutralizing antibody NT-193 complex

  喜多俊介; 小野寺大志; 安達悠; 森山彩野; 野村尚生; 田所高志; 安楽佑樹; 湯本航平; 田聡; 福原秀雄; 鈴木干城; 橋口隆生; 高橋宜聖; 前仲勝実

  量子ビームサイエンスフェスタ(Web), 2022

  
• Inhibitory mechanisms of virus cellular entry: structure-guided drug development

  橋口隆生

  日本細菌学雑誌(Web), 2020

  
• ウイルスの細胞侵入機構を標的とした創薬モダリティ

  橋口隆生

  構造活性フォーラム講演要旨集, 2019

  
• 構造情報を活用したおたふくかぜ・はしかウイルス感染阻害メカニズムの解明と創薬展開

  橋口隆生

  日本生化学会大会(Web), 2019

  
• おたふくかぜはどのように感染発症するのでしょうか,なぜワクチンが有効なのでしょうか

  橋口隆生

  外来小児科, 20 Jul. 2018

  
• Molecular basis for negative-strand RNA virus entry and neutralization by antibodies

  橋口 隆生

  ウイルス = Virus, Jun. 2017

  
• Development of single chain Fv of neutralizing antibody to measles virus targeting the receptor binding site of hemagglutinin

  Takashi Tadokoro; Lubna Mst Jahan; Atsutoshi Imai; Natsumi Sugimura; Koki Yoshida; Mizuki Saito; Yuri Ito; Surui Chen; Takao Hashiguchi; Yusuke Yanagi; Maino Tahara; Makoto Takeda; Hideo Fukuhara; Katsumi Maneaka

  PROTEIN SCIENCE, Oct. 2016

  
• The Molecular Tool-Kit of Viral Hemorrhagic Fevers

  Erica Ollmann Saphire; Zach Bornholdt; Marnie Fusco; Dafna Abelson; Takao Hashiguchi; Jeffrey Lee; Yoshihiro Kawaoka; John Dye; James Crowe

  FASEB JOURNAL, Apr. 2015

  
• 麻疹ウイルスと受容体SLAMの相互作用と膜融合

  橋口隆生; 白銀勇太; 前仲勝実; 柳雄介

  日本ウイルス学会学術集会プログラム・抄録集, 15 Oct. 2010

  
• 麻疹ウイルスによる細胞侵入機構の構造基盤

  橋口隆生; 尾瀬農之; 上敷領淳; 柳雄介; 前仲勝実

  日本蛋白質科学会年会プログラム・要旨集, 15 May 2010

  
• 麻疹ウイルスHタンパク質と受容体SLAMの複合体の結晶構造と麻疹ウイルスの細胞侵入機構

  橋口隆生; 尾瀬農之; 上敷領淳; 竹田誠; 前仲勝実; 柳雄介

  日本ウイルス学会学術集会プログラム・抄録集, 01 Oct. 2009

  
• 麻疹ウイルスHタンパク質による受容体認識の構造基盤

  橋口隆生; 橋口隆生; 竹田誠; 田原舞乃; 池亀聡; 大野真治; 柳雄介

  日本ウイルス学会学術集会プログラム・抄録集, 01 Oct. 2008

  
• 麻疹ウイルスHタンパク質のX線結晶構造解析

  橋口隆生; 梶川瑞穂; 真板宣夫; 竹田誠; 黒木喜美子; 佐々木香織; 柳雄介; 前仲勝実

  補体シンポジウム講演集, Jul. 2008

  
• 麻疹ウイルス感染におけるレセプターSLAM上の糖鎖の意義

  橋口隆生; 久保田万理恵; 竹田誠; 大野真治; 柳雄介

  日本ウイルス学会学術集会プログラム・抄録集, 01 Oct. 2007

  
• X線結晶構造解析による麻疹ウイルスHタンパク質のレセプター認識の構造基盤

  橋口隆生; 竹田誠; 柳雄介

  日本ウイルス学会学術集会プログラム・抄録集, 01 Oct. 2007

  

Presentations

• Inhibitory mechanisms of virus cellular entry: structure-guided drug development

  橋口隆生

  日本細菌学雑誌(Web), 2020

  
• Structure-guided and computer-aided drug development to ameliorate persistent measles virus infection in the central nervous system

  Takao Hashiguchi

  Japan-UK Workshop on Infectious Disease Research（AMED-英国大使館主催）, 21 Jan. 2019, Invited

  
• 小児ウイルス感染症とその感染阻害機構

  橋口 隆生

  第５回 外力支援型バイオアッセイ技術コンソーシアム 技術セミナー・技術交流会（産総研）, 11 Jan. 2019, Invited

  
• 構造情報を活用したおたふくかぜ・はしかウイルス感染阻害メカニズムの解明と創薬展開

  橋口隆生

  日本生化学会大会(Web), 2019

  
• ウイルスの細胞侵入機構を標的とした創薬モダリティ

  橋口隆生

  構造活性フォーラム講演要旨集, 2019

  
• おたふくかぜ・麻疹（はしか）の感染制御に向けて

  橋口 隆生

  埼玉大学 先端産業国際ラボラトリー 第8回ワークショップ-感染症に挑む, 12 Dec. 2018, Invited

  
• Drug-repositioning screening for anti-viral therapeutics of mumps virus infection

  Iori Okabe; Satoshi Shindo; Yuma Sato; Marie Kubota; Aya Ueo; Satoko Otuguro; Katsumi Maenaka; Yusuke Yanagi; Takao Hashiguchi

  The 66th Annual meeting of the Japanese Society for Virology, 30 Oct. 2018

  
• 原子の世界でウイルスを視る、制御する

  橋口 隆生

  ラブラボ 2018（東京大学医科学研究所）, 03 Aug. 2018, Invited

  
• Measles virus-mediated membrane fusion linked with CNS disorders

  Takao Hashiguchi

  EMBO Workshop, Membrane fusion in health and disease Cambridge, 25 Jun. 2018

  
• モノネガウイルスの細胞侵入およびその阻害機構の研究と創薬への展開

  橋口 隆生

  AMED 新興再興事業・J-GRID合同シンポジウム 感染症研究連携のフロンティア, 23 Mar. 2018, Invited

  
• Molecular dissection of virus entry and its inhibition by antibodies/inhibitors

  Takao Hashiguchi

  Immunology at the Forefront - The 9th International Symposium of IFReC, 26 Jan. 2018, Invited

  
• 構造生物学的手法を活用したRNAウイルスの細胞侵入機構および抗体による中和機構の研究

  橋口 隆生

  第4回タンパク質X線溶液散乱講習会, 12 Dec. 2017, Invited

  
• Molecular basis for Mononegavirus entry and inhibitions by antibodies/inhibitors

  Takao Hashiguchi

  The 16th Awaji International Forum on Infection and Immunity, 06 Sep. 2017, Invited

  
• ムンプスウイルスの細胞侵入機構と糖鎖受容体

  橋口 隆生

  第31回インフルエンザ研究者交流の会シンポジウム, 08 Jun. 2017, Invited

  
• 糖鎖受容体を介したムンプスウイルス細胞侵入メカニズムの構造生物学的・ウイルス学的解析

  橋口 隆生

  The 6th Negative Strand Virus-Japan Symposium, 16 Jan. 2017

  
• Characterization of Neutralizing Antibodies against Measles Virus

  Yoshinari Fukuda; Takao Hashiguchi; Shinji Ohno; Yusuke Yanagi

  The 64th Annual meeting of the Japanese Society for Virology, 24 Oct. 2016

  
• Molecular basis for negative-strand RNA virus entry and neutralization by antibodies

  Takao Hashiguchi

  The 64th Annual meeting of the Japanese Society for Virology, 24 Oct. 2016, Invited

  
• Tetrameric interaction of the mumps virus hemagglutinin-neuraminidase head domain is critical for triggering membrane fusion

  Iori Okabe; Marie Kubota; Shin-ichi Nakakita; Takao Hashiguchi; Yusuke Yanagi

  The 64th Annual meeting of the Japanese Society for Virology, 23 Oct. 2016

  
• Linear saccharide moiety containing α2,3-linked sialic acid, rather than the sialic acid alone, constitutes a receptor for mumps virus

  Marie Kubota; Kaoru Takeuchi; Shumpei Watanabe; Shinji Ohno; Rei Matsuoka; Daisuke Kohda; Shin-ichi Nakakita; Hiroaki Hiramatsu; Yasuo Suzuki; Tetsuo Nakayama; Tohru Terada; Kentaro Shimizu; Nobutaka Shimizu; Yusuke Yanagi; Takao Hashiguchi

  The 64th Annual meeting of the Japanese Society for Virology, 23 Oct. 2016

  
• Structural basis for Ebola and Marburg virus neutralization by antibodies

  Takao Hashiguchi; Yusuke Yanagi; Rei Matsuoka; Daisuke Kohda; Erica Ollmann Saphire

  第16回日本蛋白質科学会, 07 Jun. 2016

  
• Inhibitory mechanisms of anti-filovirus antibodies on Marburg and Ebola virus entry

  Takao Hashiguchi

  Institute for Protein Research(IPR) International Seminar IPR / CRED / PDIS Joint Seminar, 12 Jan. 2016, Invited

  
• Structural basis for filovirus neutralization by antibodies

  Takao Hashiguchi

  The 63rd Annual meeting of the Japanese Society for Virology, 25 Nov. 2015, Invited

  
• 抗体によるエボラ・マールブルグウイルスの中和の構造基盤

  橋口 隆生

  第2回感染コンピテンシー若手研究会, 17 Jul. 2015, Invited

  
• 抗体によるフィロウイルスの中和の構造基盤

  橋口 隆生

  感染症国際研究センター/全国共同利用・共同研究拠点 若手ジョイントシンポジウム, 18 Feb. 2015, Invited

  
• マールブルグウイルス糖蛋白質 GP とヒト由来抗体の X 線結晶構造

  橋口 隆生; 柳 雄介; Erica Ollmann Saphire

  第62回 日本ウイルス学会, 10 Nov. 2014

  
• モノネガウイルスワクチンの有効性と新規開発の構造基盤

  橋口 隆生

  感染・炎症・免疫・発癌 (北海道大学遺伝子病制御研究所), 04 Jul. 2014, Invited

  
• マールブルグウイルスの細胞侵入の構造基盤

  橋口 隆生; Erica Ollmann Saphire

  第61回 日本ウイルス学会, 11 Nov. 2013

  
• Structures of measles virus hemagglutinin provide virus entry and effective measles vaccine

  Hashiguchi T; Nakashima, M; Shirogane, Y; Maenaka, K; Yanagi, Y

  The 12th Awaji International Forum on Infection and Immunity, 11 Sep. 2013, Invited

  
• Structural and functional insight into measles virus hemagglutinin

  Hashiguchi T; Kubota M; Nakashima M; Shirogane Y; Ose T; Maenaka K; Yanagi Y

  7th International Conference on Structural Genomics (ICSG2013-SLS), 30 Jul. 2013

  
• Crystal structure of the measles virus hemagglutinin sheds light on its interaction with cellular receptors and antibodies

  Hashiguchi T; Takeda M; Maenaka K; Yanagi Y

  The 27th Annual Meeting of American Scociety for Virology, Jul. 2008

  

Books and Other Publications

• Viral Biophysics: Contributions to Drug Modalities

  前仲勝実; 福原秀雄; 橋口隆生; CAAVEIRO Jose M. M; 長門石曉; 黒田大祐; 津本浩平; 津本浩平, Joint work

  2021

  
• Mumps virus receptors

  橋口隆生

  臨床とウイルス, 2019

  
• 最先端微生物学研究に基づいた疾病対策の試み X線結晶構造に基づくパラミクソウイルスの細胞侵入阻害機構と創薬への展開

  橋口隆生

  獣医畜産新報, Jun. 2018, Not refereed

  
• RNAウイルスの細胞侵入機構の構造基盤の解明

  橋口隆生

  感染・炎症・免疫, Oct. 2017, Not refereed

  
• マイナス鎖RNAウイルスの細胞侵入と抗体による中和の研究

  橋口隆生

  ウイルス, Jun. 2017, Not refereed

  
• ウイルスの増殖・病態発現機構に関する最新の知見 ムンプスウイルスの糖鎖受容体—ムンプスウイルスのHN蛋白質と糖鎖との相互作用解析

  久保田万理恵; 橋口隆生; 柳雄介

  医学のあゆみ, Feb. 2017, Not refereed

  
• 感染症研究のいま~メカニズムから予防・治療まで III.予防・治療に向けた研究 10.抗体医薬研究の最前線と展望

  橋口隆生

  実験医学, Nov. 2015, Not refereed

  
• 交差反応性を示すヒトの抗体によるマールブルグウイルスの中和の分子機構

  橋口隆生; Erica Ollman Saphire

  ライフサイエンス新着論文レビュー, Mar. 2015, Not refereed

  
• 抗ウイルス薬 IV.特論 麻疹ウイルスと受容体との複合体の立体構造と今後の展望

  前仲勝実; 橋口隆生; 柳雄介

  日本臨床, Apr. 2012, Not refereed

  
• 受容体SLAMと結合した麻疹ウイルスHタンパク質の構造

  橋口隆生; 前仲勝実; 柳雄介

  ライフサイエンス新着論文レビュー, Feb. 2011, Not refereed

  
• 麻疹ウイルス受容体結合タンパク質のX線結晶構造解析

  橋口隆生; 柳雄介

  感染、炎症、免疫, Apr. 2009, Not refereed

  
• 麻疹ウイルス研究の最近の進歩

  柳雄介; 竹田誠; 橋口隆生

  小児感染免疫, Dec. 2008, Not refereed

  
• 麻疹ウイルスの受容体と病態

  竹田誠; 橋口隆生; 柳雄介

  実験医学, Nov. 2008, Not refereed

  
• ヒト培養細胞を用いた組換え蛋白質の発現 -293系統細胞によるスタンダードプロトコール-

  橋口隆生; 梶川瑞穂; 竹田誠; 柳雄介; 前仲勝実

  蛋白質科学プロトコール 蛋白質科学会 Webアーカイブ, Jun. 2008, Not refereed

  
• 麻疹ウイルスHタンパク質のX線結晶構造

  橋口隆生; 前仲勝実; 柳雄介

  ウイルス, Jun. 2008, Not refereed

  
• 結晶構造が解き明かす麻疹ウイルスワクチン成功の理由

  橋口隆生; 柳雄介; 前仲勝実

  Medical Bio, Jan. 2008, Not refereed

  

Awards

• 13 Dec. 2017

  内閣官房 健康・医療戦略室, 第１回 日本医療研究開発大賞 AMED理事長賞
• 24 Oct. 2016

  日本ウイルス学会, 日本ウイルス学会　杉浦奨励賞
• 2016

  文部科学省, 文部科学大臣表彰　若手科学者賞

External funds: Kakenhi

• Transporting drugs across the blood-brain barrier through information technology

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 62:Applied informatics and related fields

  The University of Tokyo

  黒田 大祐

  From 09 Jul. 2021, To 31 Mar. 2025, Granted

  薬物脳内輸送;DDS;情報技術;シミュレーション;機械学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K18310/
• 情報科学的アプローチを活用した精密な機能性分子設計システムの構築

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  橋口 隆生

  From 30 Jul. 2020, To 31 Mar. 2024, Granted

  ウイルス学;構造生物学;化合物＋ペプチド;感染阻害

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K20596/
• Study of mechanisms of viral PLAMP production and PLAMP-mediated regulation of pathogenicity

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  Takao Hashiguchi

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  膜融合;構造;エントリー;PLAMP;ウイルス学;構造生物学;自己・非自己

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05773/
• Management of PLAMP research

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Osaka University

  山本 雅裕

  From 02 Oct. 2020, To 31 Mar. 2023, Granted

  PLAMP;マネジメント;病原体;ライフサイクル;自己;非自己

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-20H05770/
• Understanding the mechanism of infection dynamics of paramyxoviruses caused by abnormal membrane fusion and its inhibition

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49060:Virology-related

  Kyoto University

  Takao Hashiguchi

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  膜融合;構造;エントリー;ウイルス学;構造生物学;パラミクソウイルス;神経感染

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03497/
• Mechanism of measles virus spread in the brain

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Nagasaki University;Kyushu University

  Yusuke YANAGI

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  麻疹ウイルス;亜急性硬化性全脳炎;膜融合;神経細胞;神経

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00507/
• A novel approach for antibody design utilizing structural biology

  Grant-in-Aid for Challenging Research (Exploratory)

  Kyushu University

  Takao Hashiguchi

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  抗体;感染症;構造生物学;コンピュータ科学;構造;ウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19562/
• Structural basis for the mechanisms of virus entry into host cells

  Grant-in-Aid for Young Scientists (A)

  Kyushu University

  Takao Hashiguchi

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  感染症;ウイルス;蛋白質;構造解析;抗体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26713018/
• 麻疹ウイルスの細胞侵入・複製・出芽に関わる蛋白質のX線結晶構造解析

  Grant-in-Aid for Research Activity Start-up

  Kyushu University

  橋口 隆生

  From 30 Aug. 2013, To 31 Mar. 2015, Declined

  ウイルス学;構造生物学;麻疹ウイルス;感染症;蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25893161/
• Interplay between viruses and their host cells

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyushu University

  Yusuke Yanagi

  From 28 Jun. 2012, To 31 Mar. 2017, Project Closed

  ウイルス;免疫学;感染症;微生物;蛋白質;麻疹ウイルス;ヘルペスウイルス;膜融合;タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24115005/
• パラミクソウイルスの糖鎖受容体認識機構と宿主域・トロピズムの解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49060:Virology-related

  Kyoto University

  橋口 隆生

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ウイルス学;構造生物学;糖鎖生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02725/
• パラミクソウイルスの糖鎖受容体認識機構と宿主域・トロピズムの解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49060:Virology-related

  Kyoto University

  橋口 隆生

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ウイルス学;構造生物学;糖鎖生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27416/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Industry-academia Collaborative Internship B

  8306, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Biochemistry B

  8206, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  International Skills Practice B

  8304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Infectious disease medicine I

  8015, Fall, Faculty of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Infection and Host Defense I

  C216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Infection and Host Defense 2

  A217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Infection and Host Defense 1

  A216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Infection and Host Defense II

  C217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Infectious disease medicine I

  8015, Fall, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense 1

  A216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense II

  C217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense I

  C216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense 2

  A217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Clinical Pharmacy

  6001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Infection and Host Defense I

  C216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Pharmaceutical Biochemistry B

  8206, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Infectious disease medicine I

  8015, Fall, Faculty of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Infection and Host Defense II

  C217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Infection and Host Defense 2

  A217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Infection and Host Defense 1

  A216, Spring, Faculty of Pharmaceutical Sciences, 2
• From Apr. 2021, To Mar. 2022

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense I

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense II

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense 2

  Fall, 薬学部

Participation in PhD Defense

• 気道炎症における2型自然リンパ球の維持及び活性化に対する局所インターロイキン7の機能に関する研究

  TAKAMI DAICHI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• シングルセルトランスクリプトーム解析を駆使したウイルス感染に対する動物種特異的自然免疫応答の同定

  ASO HIROFUMI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023

Part-time lecturer

• From 01 Oct. 2023, To 31 Mar. 2024

  病原細菌学

  山口大学大学院医学系研究科
• From 01 Oct. 2023, To 31 Mar. 2024

  「ウイルス学（総論）」

  九州大学医学部・大学院医学系学府

Administration

Faculty management (title, position)

• From 01 Apr. 2024

  予算委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2026

  医学研究科ヘルスセキュリティセンター運営委員会　委員
• From 01 Apr. 2024

  広報委員会　委員
• From 01 Apr. 2024

  医生物学研究所　研究支援室　広報ユニット
• From 01 Apr. 2023, To 31 Mar. 2024

  広報委員会　委員長
• From 01 Apr. 2023

  教育委員会　委員長
• From 01 Apr. 2022

  医の倫理委員会 委員
• From 01 Apr. 2021, To 31 Mar. 2022

  ウイルス感染症・生命科学先端融合的共同研究拠点運営委員会
• From 01 Apr. 2021, To 31 Mar. 2022

  ウイルス感染症・生命科学先端融合的共同研究拠点専門委員会