Researchers Information System

日本語に切り替えるswitch to english

Woltjen, Knut

Center for iPS Cell Research and Application (CiRA) Associate Professor

Woltjen, Knut
list
    Last Updated :2022/08/08

    Basic Information

    Academic Degree

    • Ph.D.(University of Calgary)

    Research History

    • From Apr. 2013, To Mar. 2018
      Kyoto University, Center for iPS Cell Research and Application (CiRA)/ Hakubi Center for Advanced Research, Associate Professor
    • From Apr. 2010, To Mar. 2013
      Kyoto University, Center for iPS Cell Research and Application (CiRA), Assistant Professor
    • From Feb. 2009, To Mar. 2010
      Ontario Human iPS Cell Facility, The Hospital For Sick Children, iPS Cell Facility Manager
    • From Sep. 2006, To Mar. 2010
      Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Dr. Andras Nagy Lab, Postdoctoral Research Fellow
    • From Jan. 2005, To Aug. 2006
      University of Calgary, Centre for Mouse Genomics, Molecular/Gene Targeting Consultant
    • From Oct. 2001, To Mar. 2003
      Kyushu University, Faculty of Medicine, Dr.Teruhisa Tsuzuki Lab, Monbukagakusho Research Student

    Language of Instruction

    • Japanese
    • English

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2022/08/08

      Research

      Research Interests

      • 遺伝子ターゲティング
      • SNP
      • pluripotent stem cells
      • transposons
      • recombinases
      • CRISPR
      • iPS cells
      • molecular genetics
      • genome editing

      Research Areas

      • Life sciences, Genetics
      • Life sciences, Developmental biology
      • Life sciences, Cell biology
      • Life sciences, Medical biochemistry
      • Life sciences, Molecular biology
      • Life sciences, Genomics
      • Life sciences, Genomics

      Papers

      • A stress-reduced passaging technique improves the viability of human pluripotent cells.
        Kazutoshi Takahashi; Chikako Okubo; Michiko Nakamura; Mio Iwasaki; Yuka Kawahara; Tsuyoshi Tabata; Yousuke Miyamoto; Knut Woltjen; Shinya Yamanaka
        Cell reports methods, 28 Feb. 2022
      • iPSC-based drug repositioning identifies Src/c-Abl as a therapeutic target for ALS motor neurons.
        Imamura K; Izumi Y; Watanabe A; Tsukita K; Woltjen K; Yamamoto T; Hotta A; Kondo T; Kitaoka S; Ohta A; Tanaka A; Watanabe D; Morita M; Kaji R; Takuma H; Tamaoka A; Kunath T; Wray S; Furuya H; Era T; Fujisawa T; Nishotoh H; Kengo H; Ichijo H; Julien J-P; Obata N; Hosokawa M; Akiyama H; Ayaki T; Ito H; Takahashi R; Yamanaka S; Inoue H
        Science Translational Medicine, May 2017, Peer-reviewed
      • The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
        Kenji Ito; Kohei Nagata; Sho Ohta; Yutaka Matsuda; Tomoyo Ukai; Ichiro Yasuda; Akira Ota; Ryota Kobayashi; Mio Kabata; Nao Sankoda; Tatsuya Maeda; Knut Woltjen; Liying Yang; Reo Maruyama; Ryohei Katayama; Takuya Yamamoto; Yasuhiro Yamada
        Cell Reports, Apr. 2022
      • DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
        Jumpei Taguchi; Hirofumi Shibata; Mio Kabata; Masaki Kato; Kei Fukuda; Akito Tanaka; Sho Ohta; Tomoyo Ukai; Kanae Mitsunaga; Yosuke Yamada; So I Nagaoka; Sho Yamazawa; Kotaro Ohnishi; Knut Woltjen; Tetsuo Ushiku; Manabu Ozawa; Mitinori Saitou; Yoichi Shinkai; Takuya Yamamoto; Yasuhiro Yamada
        Nature Communications, Dec. 2021
      • Capturing human trophoblast development with naive pluripotent stem cells in vitro
        Shingo Io; Mio Kabata; Yoshiki Iemura; Katsunori Semi; Nobuhiro Morone; Atsutaka Minagawa; Bo Wang; Ikuhiro Okamoto; Tomonori Nakamura; Yoji Kojima; Chizuru Iwatani; Hideaki Tsuchiya; Belinda Kaswandy; Eiji Kondoh; Shin Kaneko; Knut Woltjen; Mitinori Saitou; Takuya Yamamoto; Masaki Mandai; Yasuhiro Takashima
        Cell Stem Cell, Apr. 2021
      • Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.
        Nao Sankoda; Wataru Tanabe; Akito Tanaka; Hirofumi Shibata; Knut Woltjen; Tsutomu Chiba; Hironori Haga; Yoshiharu Sakai; Masaki Mandai; Takuya Yamamoto; Yasuhiro Yamada; Shinji Uemoto; Yoshiya Kawaguchi
        Nature communications, 25 Jan. 2021
      • Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation.
        Thomas L Maurissen; Knut Woltjen
        Nature communications, 08 Jun. 2020, Peer-reviewed
      • Recapitulating the human segmentation clock with pluripotent stem cells.
        Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Thomas L Maurissen; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Noriaki Kawakami; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev
        Nature, Apr. 2020, Peer-reviewed
      • Smarcb1 maintains the cellular identity and the chromatin landscapes of mouse embryonic stem cells.
        Sakakura M; Ohta S; Yagi M; Tanaka A; Norihide J; Woltjen K; Yamamoto T; Yamada Y
        Biochemical and biophysical research communications, Nov. 2019, Peer-reviewed
      • Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations.
        Janin Grajcarek; Jean Monlong; Yoko Nishinaka-Arai; Michiko Nakamura; Miki Nagai; Shiori Matsuo; David Lougheed; Hidetoshi Sakurai; Megumu K Saito; Guillaume Bourque; Knut Woltjen
        Nature communications, 24 Oct. 2019, Peer-reviewed
      • Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate
        Arai, Hiroyuki N; Sato, Fuminori; Yamamoto, Takuya; Woltjen, Knut; Kiyonari, Hiroshi; Yoshimoto, Yuki; Shukunami, Chisa; Akiyama, Haruhiko; Kist, Ralf; Sehara-Fujisawa, Atsuko
        CELL REPORTS, 15 Oct. 2019, Peer-reviewed
      • Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas.
        Shingo Komura; Kenji Ito; Sho Ohta; Tomoyo Ukai; Mio Kabata; Fumiaki Itakura; Katsunori Semi; Yutaka Matsuda; Kyoichi Hashimoto; Hirofumi Shibata; Masamitsu Sone; Norihide Jo; Kazuya Sekiguchi; Takatoshi Ohno; Haruhiko Akiyama; Katsuji Shimizu; Knut Woltjen; Manabu Ozawa; Junya Toguchida; Takuya Yamamoto; Yasuhiro Yamada
        Nature communications, 05 Sep. 2019, Peer-reviewed
      • De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency.
        Yagi M; Kabata M; Ukai T; Ohta S; Tanaka A; Shimada Y; Sugimoto M; Araki K; Okita K; Woltjen K; Hochedlinger K; Yamamoto T; Yamada Y
        Stem cell reports, May 2019, Peer-reviewed
      • Platforms of in vivo genome editing with inducibleCas9for advanced cancer modeling
        Norihide Jo; Yuko Sogabe; Yosuke Yamada; Tomoyo Ukai; Harunobu Kagawa; Kanae Mitsunaga; Knut Woltjen; Yasuhiro Yamada
        Cancer Science, Mar. 2019, Peer-reviewed
      • Modeling the Human Segmentation Clock with Pluripotent Stem Cells
        Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K. Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev
        bioRxiv, Feb. 2019
      • OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates.
        Kagawa H; Shimamoto R; Kim SI; Oceguera-Yanez F; Yamamoto T; Schroeder T; Woltjen K
        Stem cell reports, Feb. 2019, Peer-reviewed
      • Microhomology-assisted scarless genome editing in human iPSCs
        Shin-Il Kim; Tomoko Matsumoto; Harunobu Kagawa; Michiko Nakamura; Ryoko Hirohata; Ayano Ueno; Maki Ohishi; Tetsushi Sakuma; Tomoyoshi Soga; Takashi Yamamoto; Knut Woltjen
        Nature Communications, 01 Dec. 2018, Peer-reviewed
      • In vivo reprogramming drives Kras-induced cancer development
        Hirofumi Shibata; Shingo Komura; Yosuke Yamada; Nao Sankoda; Akito Tanaka; Tomoyo Ukai; Mio Kabata; Satoko Sakurai; Bunya Kuze; Knut Woltjen; Hironori Haga; Yatsuji Ito; Yoshiya Kawaguchi; Takuya Yamamoto; Yasuhiro Yamada
        Nature Communications, 01 Dec. 2018, Peer-reviewed
      • Editorial overview: Embroidering the canvas of life.
        Woltjen K; Bortvin A
        Current opinion in genetics & development, Oct. 2018, Peer-reviewed
      • 正しい分化経路をたどったiPS細胞由来T細胞は固形腫瘍に対して優れた集積性および治療効果を示す
        上田 樹; 入口 翔一; 河合 洋平; 南川 淳隆; 三好 浩之; 寺倉 精太郎; 植村 靖史; 中面 哲也; 玉田 耕治; ウォルツェン・クヌート; 児玉 裕三; 妹尾 浩; 金子 新
        日本がん免疫学会総会プログラム・抄録集, Jul. 2018
      • Generation of CAR-iPS-T cells expressing CD8 beta
        Ueda Tatsuki; Iriguchi Shoichi; Kawai Yohei; Minagawa Atsutaka; Miyoshi Hiroyuki; Terakura Seitaro; Uemura Yasushi; Woltjen Knut; Kodama Yuzo; Seno Hiroshi; Hitoshi Yasumichi; Nakatsura Tetsuya; Tamada Koji; Kaneko Shin
        CANCER RESEARCH, Jul. 2018, Peer-reviewed
      • Beta-cell replacement strategies for diabetes
        Timothy J Kieffer; Knut Woltjen; Kenji Osafune; Daisuke Yabe; Nobuya Inagaki
        Journal of Diabetes Investigation, 01 May 2018, Peer-reviewed
      • Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs.
        Takashi Ikeda; Takafusa Hikichi; Hisashi Miura; Hirofumi Shibata; Kanae Mitsunaga; Yosuke Yamada; Knut Woltjen; Kei Miyamoto; Ichiro Hiratani; Yasuhiro Yamada; Akitsu Hotta; Takuya Yamamoto; Keisuke Okita; Shinji Masui
        Nature communications, 11 Apr. 2018, Peer-reviewed
      • iPSC-based CAR-T therapy targeting for GPC3
        Ueda Tatsuki; Irigchi Shoich; Kawai Youhei; Minagawa Atsutaka; Miyoshi Hiroyuki; Terakura Seitaro; Uemura Yasushi; Woltjen Knut; Kodama Yuzo; Tamada Koji; Nakatsura Tetsuya; Seno Hiroshi; Kaneko Shin
        CANCER SCIENCE, Jan. 2018, Peer-reviewed
      • iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid beta Combination for Alzheimer's Disease
        Takayuki Kondo; Keiko Imamura; Misato Funayama; Kayoko Tsukita; Michiyo Miyake; Akira Ohta; Knut Woltjen; Masato Nakagawa; Takashi Asada; Tetsuaki Arai; Shinobu Kawakatsu; Yuishin Izumi; Ryuji Kaji; Nobuhisa Iwata; Haruhisa Inoue
        CELL REPORTS, Nov. 2017, Peer-reviewed
      • Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells.
        Yoji Kojima; Kotaro Sasaki; Shihori Yokobayashi; Yoshitake Sakai; Tomonori Nakamura; Yukihiro Yabuta; Fumio Nakaki; So Nagaoka; Knut Woltjen; Akitsu Hotta; Takuya Yamamoto; Mitinori Saitou
        Cell stem cell, 05 Oct. 2017, Peer-reviewed
      • Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch
        Moe Hirosawa; Yoshihiko Fujita; Callum J. C. Parr; Karin Hayashi; Shunnichi Kashida; Akitsu Hotta; Knut Woltjen; Hirohide Saito
        NUCLEIC ACIDS RESEARCH, Jul. 2017, Peer-reviewed
      • Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency
        Masamitsu Sone; Nobuhiro Morone; Tomonori Nakamura; Akito Tanaka; Keisuke Okita; Knut Woltjen; Masato Nakagawa; John E. Heuser; Yasuhiro Yamada; Shinya Yamanaka; Takuya Yamamoto
        Cell Metabolism, May 2017, Peer-reviewed
      • The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
        Keiko Imamura; Yuishin Izumi; Akira Watanabe; Kayoko Tsukita; Knut Woltjen; Takuya Yamamoto; Akitsu Hotta; Takayuki Kondo; Shiho Kitaoka; Akira Ohta; Akito Tanaka; Dai Watanabe; Mitsuya Morita; Hiroshi Takuma; Akira Tamaoka; Tilo Kunath; Selina Wray; Hirokazu Furuya; Takumi Era; Kouki Makioka; Koichi Okamoto; Takao Fujisawa; Hideki Nishitoh; Kengo Homma; Hidenori Ichijo; Jean-Pierre Julien; Nanako Obata; Masato Hosokawa; Haruhiko Akiyama; Satoshi Kaneko; Takashi Ayaki; Hidefumi Ito; Ryuji Kaji; Ryosuke Takahashi; Shinya Yamanaka; Haruhisa Inoue
        SCIENCE TRANSLATIONAL MEDICINE, May 2017, Peer-reviewed
      • Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior
        Kyoichi Hashimoto; Yosuke Yamada; Katsunori Semi; Masaki Yagi; Akito Tanaka; Fumiaki Itakura; Hitomi Aoki; Takahiro Kunisada; Knut Woltjen; Hironori Haga; Yoshiharu Sakai; Takuya Yamamoto; Yasuhiro Yamada
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2017, Peer-reviewed
      • EWS-FLI1誘導性骨肉腫モデルによって骨分化障害が肉腫発生に重要な役割をもつことが明らかとなった
        河村 真吾; 蝉 克憲; 板倉 史晃; 柴田 博史; 堀田 秋津; Woltjen Knut; 山本 拓也; 大野 貴敏; 秋山 治彦; 山田 泰広
        日本整形外科学会雑誌, Aug. 2016, Peer-reviewed
      • マウスEWS/FLI1誘導性骨肉腫モデルが明らかとした肉腫発生に関わる重要事項 EWS/FLI1とcancer genomeがもたらす細胞分化異常
        河村 真吾; 蝉 克憲; 板倉 史晃; 柴田 博史; 堀田 秋津; Woltjen Knut; 山本 拓也; 大野 貴敏; 秋山 治彦; 山田 泰広
        日本整形外科学会雑誌, Jun. 2016, Peer-reviewed
      • Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives
        Fabian Oceguera-Yanez; Shin-Il Kim; Tomoko Matsumoto; Ghee Wan Tan; Long Xiang; Takeshi Hatani; Takayuki Kondo; Makoto Ikeya; Yoshinori Yoshida; Haruhisa Inoue; Knut Woltjen
        METHODS, May 2016, Peer-reviewed
      • Report on the Conference on Transposition and Genome Engineering 2015 (TGE 2015): advancing cutting-edge genomics technology in the ancient city of Nara
        Knut Woltjen; Takashi Yamamoto; Chikara Kokubu; Junji Takeda
        GENES TO CELLS, May 2016, Peer-reviewed
      • An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development
        Shingo Komura; Katsunori Semi; Fumiaki Itakura; Hirofumi Shibata; Takatoshi Ohno; Akitsu Hotta; Knut Woltjen; Takuya Yamamoto; Haruhiko Akiyama; Yasuhiro Yamada
        STEM CELL REPORTS, Apr. 2016, Peer-reviewed
      • マウスEWS/FLI1誘導性骨肉腫モデルが明らかとした肉腫発生に関わる重要事項 EWS/FLI1とcancer genomeがもたらす細胞分化異常
        河村 真吾; 蝉 克憲; 板倉 史晃; 柴田 博史; 堀田 秋津; Woltjen Knut; 山本 拓也; 大野 貴敏; 秋山 治彦; 山田 泰広
        日本整形外科学会雑誌, Mar. 2016, Peer-reviewed
      • At the conflux of human genome engineering and induced pluripotency
        Knut Woltjen; Fabian Oceguera-Yanez; Harunobu Kagawa; Shin-Il Kim
        Genome Editing, 01 Jan. 2016, Peer-reviewed
      • The piggyBac Transposon as a Platform Technology for Somatic Cell Reprogramming Studies in Mouse.
        Woltjen K; Kim SI; Nagy A
        Methods in molecular biology (Clifton, N.J.), 2016, Peer-reviewed
      • Directed Myogenic Differentiation of Human Induced Pluripotent Stem Cells.
        Emi Shoji; Knut Woltjen; Hidetoshi Sakurai
        Methods in molecular biology (Clifton, N.J.), 2016, Peer-reviewed, Invited
      • 生体における未熟なリプログラミングの終結は絨毛がんを誘発する(Premature termination of reprogramming in vivo leads to choriocarcinoma development)
        田口 純平; 蝉 克憲; 山田 洋介; 大西 紘太郎; 柴田 博史; 光永 佳奈枝; Woltjen Knut; 山田 泰広
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015, Peer-reviewed
      • SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier
        Sakura Tamaki; Makoto Fukuta; Kazuya Sekiguchi; Yonghui Jin; Sanae Nagata; Kazuo Hayakawa; Sho Hineno; Takeshi Okamoto; Makoto Watanabe; Knut Woltjen; Makoto Ikeya; Tomohisa Kato; Junya Toguchida
        PLOS ONE, Nov. 2015, Peer-reviewed
      • Reprogramming Roadblocks Are System Dependent
        Eleni Chantzoura; Stavroula Skylaki; Sergio Menendez; Shin-Il Kim; Anna Johnsson; Sten Linnarsson; Knut Woltjen; Ian Chambers; Keisuke Kaji
        STEM CELL REPORTS, Sep. 2015, Peer-reviewed
      • Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
        Sasaki K; Yokobayashi S; Nakamura T; Okamoto I; Yabuta Y; Kurimoto K; Ohta H; Moritoki Y; Iwatani C; Tsuchiya H; Nakamura S; Sekiguchi K; Sakuma T; Yamamoto T; Mori T; Woltjen K; Nakagawa M; Yamamoto T; Takahashi K; Yamanaka S
        Cell stem cell, Aug. 2015, Peer-reviewed
      • Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes
        Yonghui Jin; Hassan Elalaf; Makoto Watanabe; Sakura Tamaki; Sho Hineno; Kazuhito Matsunaga; Knut Woltjen; Yukiko Kobayashi; Sanae Nagata; Makoto Ikeya; Tomohisa Kato; Takeshi Okamoto; Shuichi Matsuda; Junya Toguchida
        PLOS ONE, Jul. 2015, Peer-reviewed
      • KLF4 N-Terminal Variance Modulates Induced Reprogramming to Pluripotency
        Shin-Il Kim; Fabian Oceguera-Yanez; Ryoko Hirohata; Sara Linker; Keisuke Okita; Yasuhiro Yamada; Takuya Yamamoto; Shinya Yamanaka; Knut Woltjen
        STEM CELL REPORTS, Apr. 2015, Peer-reviewed
      • Synthetic lateral inhibition governs cell-type bifurcation with robust ratios
        Mitsuhiro Matsuda; Makito Koga; Knut Woltjen; Eisuke Nishida; Miki Ebisuya
        NATURE COMMUNICATIONS, Feb. 2015, Peer-reviewed
      • Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons.
        Kim SI; Oceguera-Yanez F; Sakurai C; Nakagawa M; Yamanaka S; Woltjen K
        Methods in Molecular Biology, 2015, Peer-reviewed, Invited
      • Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation
        Kotaro Ohnishi; Katsunori Semi; Takuya Yamamoto; Masahito Shimizu; Akito Tanaka; Kanae Mitsunaga; Keisuke Okita; Kenji Osafune; Yuko Arioka; Toshiyuki Maeda; Hidenobu Soejima; Hisataka Moriwaki; Shinya Yamanaka; Knut Woltjen; Yasuhiro Yamada
        CELL, Feb. 2014, Peer-reviewed
      • Nuclease-mediated genome editing: At the front-line of functional genomics technology
        Tetsushi Sakuma; Knut Woltjen
        DEVELOPMENT GROWTH & DIFFERENTIATION, Jan. 2014, Peer-reviewed
      • 1P135 Reconstitution of an intercellular symmetry breaking mechanism(09. Development & Differentiation,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))
        Matsuda Mitsuhiro; Koga Makito; Woltjen Knut; Nishida Eisuke; Ebisuya Miki
        Seibutsu Butsuri, 2014
      • Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway.
        Gallagher D; Norman AA; Woodard CL; Yang G; Gauthier-Fisher A; Fujitani M; Vessey JP; Cancino GI; Sachewsky N; Woltjen K; Fatt MP; Morshead CM; Kaplan DR; Miller FD
        Cell Stem Cell, Nov. 2013, Peer-reviewed
      • iPS細胞技術を用いた滑膜肉腫起源の同定への試み
        福田 誠; 早川 和男; 玉置 さくら; 佐藤 信吾; 池谷 真; 大塚 隆信; Woltjen Knut; 戸口田 淳也
        日本整形外科学会雑誌, Aug. 2013
      • Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells
        Akihiro Yamashita; Shiying Liu; Knut Woltjen; Bradley Thomas; Guoliang Meng; Akitsu Hotta; Kazutoshi Takahashi; James Ellis; Shinya Yamanaka; Derrick E. Rancourt
        SCIENTIFIC REPORTS, Jun. 2013, Peer-reviewed
      • Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro
        Akihito Tanaka; Knut Woltjen; Katsuya Miyake; Akitsu Hotta; Makoto Ikeya; Takuya Yamamoto; Tokiko Nishino; Emi Shoji; Atsuko Sehara-Fujisawa; Yasuko Manabe; Nobuharu Fujii; Kazunori Hanaoka; Takumi Era; Satoshi Yamashita; Ken-ichi Isobe; En Kimura; Hidetoshi Sakurai
        PLOS ONE, Apr. 2013, Peer-reviewed
      • Efficient TALEN construction and evaluation methods for human cell and animal applications
        Tetsushi Sakuma; Sayaka Hosoi; Knut Woltjen; Ken-ichi Suzuki; Keiko Kashiwagi; Housei Wada; Hiroshi Ochiai; Tatsuo Miyamoto; Narudo Kawai; Yasunori Sasakura; Shinya Matsuura; Yasushi Okada; Atsuo Kawahara; Shigeo Hayashi; Takashi Yamamoto
        GENES TO CELLS, Apr. 2013, Peer-reviewed
      • Efficient TALEN construction and evaluation methods for human cell and animal applications
        Tetsushi Sakuma; Sayaka Hosoi; Knut Woltjen; Ken-Ichi Suzuki; Keiko Kashiwagi; Housei Wada; Hiroshi Ochiai; Tatsuo Miyamoto; Narudo Kawai; Yasunori Sasakura; Shinya Matsuura; Yasushi Okada; Atsuo Kawahara; Shigeo Hayashi; Takashi Yamamoto
        Genes to Cells, Apr. 2013
      • Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells
        Kazuo Hayakawa; Makoto Ikeya; Makoto Fukuta; Knut Woltjen; Sakura Tamaki; Naoko Takahara; Tomohisa Kato; Shingo Sato; Takanobu Otsuka; Junya Toguchida
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2013, Peer-reviewed
      • Highly efficient site-specific transgenesis in cancer cell lines
        Iacovos P. Michael; Claudio Monetti; Anthony C. Chiu; Puzheng Zhang; Takeshi Baba; Koichiro Nishino; Siamak Agha-Mohammadi; Knut Woltjen; Hoon-Ki Sung; Andras Nagy
        MOLECULAR CANCER, Dec. 2012, Peer-reviewed
      • Erratum to: Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts (Stem Cell Rev and Rep, 10.1007/s12015-011-9239-5)
        Kristina Nagy; Hoon-Ki Sung; Puzheng Zhang; Simon Laflamme; Patrick Vincent; Siamak Agha-Mohammadi; Knut Woltjen; Claudio Monetti; Iacovos Prodromos Michael; Lawrence Charles Smith; Andras Nagy
        Stem Cell Reviews and Reports, Jun. 2012, Peer-reviewed
      • An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming
        Mathieu Gabut; Payman Samavarchi-Tehrani; Xinchen Wang; Valentina Slobodeniuc; Dave O'Hanlon; Hoon-Ki Sung; Manuel Alvarez; Shaheynoor Talukder; Qun Pan; Esteban O. Mazzoni; Stephane Nedelec; Hynek Wichterle; Knut Woltjen; Timothy R. Hughes; Peter W. Zandstra; Andras Nagy; Jeffrey L. Wrana; Benjamin J. Blencowe
        CELL, Sep. 2011, Peer-reviewed
      • Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts
        Kristina Nagy; Hoon-Ki Sung; Puzheng Zhang; Simon Laflamme; Patrick Vincent; Siamak Agha-Mohammadi; Knut Woltjen; Claudio Monetti; Iacovos Prodromos Michael; Lawrence Charles Smith; Andras Nagy
        STEM CELL REVIEWS AND REPORTS, Sep. 2011, Peer-reviewed
      • PhiC31 integrase facilitates genetic approaches combining multiple recombinases
        Claudio Monetti; Koichiro Nishino; Steffen Biechele; Puzheng Zhang; Takeshi Baba; Knut Woltjen; Andras Nagy
        METHODS, Apr. 2011, Peer-reviewed
      • Transposon-based production of genetically unmodified induced pluripotent stem cells from human embryonic fibroblasts
        Woltjen K; Hamalainen R; Kibschull M; Mileikovsky M; Nagy A
        Methods in Molecular Biology 767 (87):103, 2011, Peer-reviewed
      • Transgene-free production of pluripotent stem cells using piggyBac transposons
        Knut Woltjen; Riikka Hämäläinen; Mark Kibschull; Maria Mileikovsky; Andras Nagy
        Methods in Molecular Biology, 2011, Peer-reviewed
      • Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming
        Payman Samavarchi-Tehrani; Azadeh Golipour; Laurent David; Hoon-Ki Sung; Tobias A. Beyer; Alessandro Datti; Knut Woltjen; Andras Nagy; Jeffrey L. Wrana
        CELL STEM CELL, Jul. 2010, Peer-reviewed
      • Obtaining Pluripotency Biomarker Signatures
        Kathryn Sciabica; Knut Woltjen; Akitsu Hotta
        GENETIC ENGINEERING & BIOTECHNOLOGY NEWS, Feb. 2010
      • Inhibition of Tgf-beta Signaling Improves Mouse Fibroblast Reprogramming
        Knut Woltjen; William L. Stanford
        CELL STEM CELL, Nov. 2009, Peer-reviewed
      • New strategies to generate induced pluripotent stem cells
        James O'Malley; Knut Woltjen; Keisuke Kaji
        CURRENT OPINION IN BIOTECHNOLOGY, Oct. 2009, Peer-reviewed
      • Virus-free induction of pluripotency and subsequent excision of reprogramming factors
        Keisuke Kaji; Katherine Norrby; Agnieszka Paca; Maria Mileikovsky; Paria Mohseni; Knut Woltjen
        NATURE, Apr. 2009, Peer-reviewed
      • piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
        Knut Woltjen; Iacovos P. Michael; Paria Mohseni; Ridham Desai; Maria Mileikovsky; Riikka Haemaelaeinen; Rebecca Cowling; Wei Wang; Pentao Liu; Marina Gertsenstein; Keisuke Kaji; Hoon-Ki Sung; Andras Nagy
        NATURE, Apr. 2009, Peer-reviewed
      • Orpheus recombination: A comprehensive bacteriophage system for murine targeting vector construction by transplacement
        Knut Woltjen; Kenichi Ito; Teruhisa Tsuzuki; Derrick E. Rancourt
        Methods in Molecular Biology, 2008, Peer-reviewed
      • Deep screening of recombination proficient bacteriophage libraries
        B Thomas; K Woltjen; DE Rancourt
        BIOTECHNIQUES, Jan. 2003, Peer-reviewed
      • Bacteriophage gene targeting vectors generated by transplacement
        C Aoyama; K Woltjen; FC Mansergh; K Ishidate; DE Rancourt
        BIOTECHNIQUES, Oct. 2002, Peer-reviewed
      • Transplacement mutagenesis. A recombination-based in situ mutagenesis protocol.
        K. Woltjen; M.W. Unger; D.E. Rancourt
        Methods in molecular biology (Clifton, N.J.), 2002, Peer-reviewed, Invited
      • Retro-recombination screening of a mouse embryonic stem cell genomic library.
        K. Woltjen; G. Bain; D.E. Rancourt
        Nucleic acids research, 2000, Peer-reviewed

      Misc.

      • 正しい分化経路をたどったiPS細胞由来T細胞は固形腫瘍に対して優れた集積性および治療効果を示す
        上田 樹; 入口 翔一; 河合 洋平; 南川 淳隆; 三好 浩之; 寺倉 精太郎; 植村 靖史; 中面 哲也; 玉田 耕治; ウォルツェン・クヌート; 児玉 裕三; 妹尾 浩; 金子 新
        日本がん免疫学会総会プログラム・抄録集, Jul. 2018
      • GPC3を標的としたiPS細胞由来CAR-T療法
        上田 樹; 入口 翔一; 河合 洋平; 南川 淳隆; 三好 浩之; 寺倉 精太郎; 植村 靖史; ウォルツェン・クヌート; 児玉 裕三; 玉田 耕治; 中面 哲也; 妹尾 浩; 金子 新
        日本癌学会総会記事, Sep. 2017
      • 変異型IDH1は遺伝子特異的なヒストン修飾を介して、間葉系幹細胞から軟骨及び骨への分化を脱制御する
        金 永輝; Elalaf Hassan; 渡辺 真; 玉置 さくら; 日根野 翔; 松永 一仁; Woltjen Knut; 岡本 健; 松田 秀一; 戸口田 淳也
        日本癌学会総会記事, Oct. 2016
      • 変異型IDH1は遺伝子特異的なヒストン修飾を介して、間葉系幹細胞から軟骨及び骨への分化を脱制御する
        金 永輝; Elalaf Hassan; 渡辺 真; 玉置 さくら; 日根野 翔; 松永 一仁; Woltjen Knut; 岡本 健; 松田 秀一; 戸口田 淳也
        日本癌学会総会記事, Oct. 2016
      • 変異型IDH1は骨・軟骨関連遺伝子のヒストンを遺伝子特異的に修飾し、間葉系幹細胞の分化能を脱制御する
        金 永輝; Elalaf Hassan; 渡辺 真; 玉置 さくら; 日根野 翔; 松永 一仁; Woltjen Knut; 岡本 健; 松田 秀一; 戸口田 淳也
        日本癌学会総会記事, Oct. 2015
      • Engineered Nuclease Mediated Genetic Correction in iPSCs Derived From Duchenne Muscular Dystrophy Patient
        Hongmei Lisa Li; Naoko Fujimoto; Noriko Sasakawa; Saya Shirai; Takashi Yamamoto; Knut Woltjen; Akira Watanabe; Hidetoshi Sakurai; Shinya Yamanaka; Akitsu Hotta
        MOLECULAR THERAPY, May 2014
      • 【ゲノム編集革命:遺伝子改変はZFN・TALEN・CRISPR/Cas三強時代へ】 TALENを用いたヒトiPS細胞におけるゲノム編集
        李 紅梅; Woltjen Knut; 高橋 和利; 山中 伸弥; 堀田 秋津
        細胞工学, Apr. 2013, Invited
      • Application of iPS cell technology \nfor the analysis of origin-unknown sarcoma characterized by a specific fusion gene.
        Hayakawa K; Fukuta M; TamaiS; Kato T; Ikeya M; Otsuka T; Woltjen K; Toguchida J
        第17 回CTOS (2012.11.16.Prague), 16 Nov. 2012, Peer-reviewed
      • Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts (vol 7, pg 693, 2011)
        Kristina Nagy; Hoon-Ki Sung; Puzheng Zhang; Simon Laflamme; Patrick Vincent; Siamak Agha-Mohammadi; Knut Woltjen; Claudio Monetti; Iacovos Prodromos Michael; Lawrence Charles Smith; Andras Nagy
        STEM CELL REVIEWS AND REPORTS, Jun. 2012
      • デュシェンヌ型筋ジストロフィー患者由来iPS 細胞を用いての病態再現
        庄子栄美; 櫻井英俊; 中畑龍俊; 田中章仁; ウォルツェンクヌート; 藤井宣晴; 平家敏男; 真鍋康子; 瀬原-藤沢淳子
        第35 回日本分子生物学会年会(2012.12.12.福岡), 2012, Peer-reviewed
      • MYF5遺伝子発現制御によるヒトiPS細胞の骨格筋分化誘導の検討
        近藤潤一; 田中章仁; WOLTJEN Knut; 沖田圭介; 櫻井英俊
        日本分子生物学会年会プログラム・要旨集(Web), 2012
      • Establishment and functional \nanalysis of iPS cells with drug-inducible SYT-SSX fusion gene.
        Fukuta M; Hayakawa K; Tamaki S; Sato S; Ikeya M; Otsuka Y; Woltjen K; Toguchida J
        第10 回ISSCR(2012.6.14.横浜), 2012, Peer-reviewed
      • PS 細胞を用いた肉腫研究:滑膜肉腫の起源細胞の解明をめざして
        福田誠; 早川和男; 玉置さくら; 沖田圭介; 池谷真; Knut Woltjen; 大塚隆信; 戸口田淳也
        第27 回日本整形外科学会基礎学術集会(2012.10.26. 名古屋), 2012, Peer-reviewed
      • 薬剤誘導型発現ベクターを用いたSYT-SSX 融合遺伝子導入iPS 細胞の樹立
        早川和男; 福田誠; 玉置さくら; 佐藤信吾; 池谷真; 大塚隆信; Knut Woltjen; 戸口田淳也
        第45 回日本整形外科学会骨軟部腫瘍学術 集会(2012.7.15.東京), 2012, Peer-reviewed

      Presentations

      • Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining
        Knut Woltjen
        2019 Keystone Symposia 『Genome Engineering: From Mechanisms to Therapies (B4)』, 21 Feb. 2019, Invited
      • The history and potential of iPSC research
        Knut Woltjen
        AAAS 2019 Annual Meeting, 15 Feb. 2019, Invited
      • 医療応用に向けたヒトiPS細胞でのゲノム編集
        ウォルツェン クヌート
        OPERA「ゲノム編集」産学共創コンソーシアム・公開シンポジウム、卓越大学院キックオフシンポジウム, 10 Dec. 2018, Invited
      • Japan’s experience in regenerative medicine and superdonor cells
        Knut Woltjen
        NRC’s HEALTH CHALLENGE PROGRAM WORKSHOP : ‘Transforming Health Outcomes through Engineered Cell and Gene Therapies’, 07 Dec. 2018, Invited
      • Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining
        Knut Woltjen
        Concordia University Seminar, 06 Dec. 2018, Invited
      • Precise human disease allele creation and correction through microhomology-mediated end joining
        Knut Woltjen
        The 41st Annual Meeting of the Molecular Biology Society of Japan, 28 Nov. 2018, Invited
      • Genome editing in stem cells to study the mechanisms of reprogramming and human disease
        Knut Woltjen
        Basel Stem Cell Network (BSCN) International Lecture Series(@ETH Zürich, D-BSSE), 14 Sep. 2018, Invited
      • Creation and correction of human disease alleles in iPSCs through microhomology-mediated end joining
        Knut Woltjen
        EMBO at BASEL LIFE 2018, 13 Sep. 2018
      • Precise human disease allele creation and correction through microhomology-mediated end joining
        Knut Woltjen
        IREM seminar( University of Zurich), 12 Sep. 2018, Invited
      • Precise human disease allele creation and correction through microhomology-mediated end joining
        Knut Woltjen
        Genome Engineering: The CRISPR-Cas Revolution, 25 Aug. 2018, Invited
      • Employing microhomology-mediated end joining for the creation and correction of human disease alleles
        Knut Woltjen
        Developmental Biology Guest Research Seminar(Memorial Sloan Kettering Cancer Center), 22 Aug. 2018, Invited
      • Scarless editing of human disease alleles through microhomology-mediated end joining (MMEJ)
        Knut Woltjen
        3rd Annual Meeting of The Japanese Society for Genome Editing, 19 Jun. 2018, Invited
      • GENES AND CELLS: THE LIVING DRUGS OF A NEW MEDICAL ERA
        Knut Woltjen
        "Stem Cells and Regenerative Medicine: What does the Future Hold?" (The University of British Columbia ), 29 Mar. 2018, Invited
      • The development of induced pluripotent stem cells and emerging tools for genome editing
        Knut Woltjen
        "Stem Cells and Regenerative Medicine: What does the Future Hold?" (The University of British Columbia ), 28 Mar. 2018, Invited
      • Creation and correction of human disease alleles through microhomology-mediated end joining (MMEJ)
        Knut Woltjen
        The 9th Takeda Science Foundation Symposium on PharmaSciences, 07 Feb. 2018, Invited
      • Endogenous DNA repair pathways for gene editing in human induced pluripotent stem cells
        Knut Woltjen
        Celllular & Physiological Sciences Departmental Seminar(The University of British Columbia ), 14 Sep. 2017, Invited
      • Genetic engineering of iPS cells for modelling genodermatoses
        Knut Woltjen
        The 38th Annual Meeting of the Japanese Society of Inflammation and Regeneration, 19 Jul. 2017, Invited
      • Simultaneous derivation of point-mutants and concordant isogenic clones from human iPSCs
        Knut Woltjen
        2nd Annual Meeting of The Japanese Society for Genome Editing, 29 Jun. 2017, Invited
      • Genetic engineering of pluripotent stem cells by CRISPR/Cas
        Knut Woltjen
        糖尿病ミニシンポジウム「Kyoto Diabetes Mini-Symposium – Beta-Cell Replacement Strategies」, 05 Jun. 2017, Invited
      • Engineering iPS cell models of human disease
        Knut Woltjen
        The 75th Annual Meeting of the Japanese Cancer Association, 07 Oct. 2016, Invited
      • An epithelial program driven by KLF4 stoichiometry determines hallmarks of somatic cell reprogramming
        Knut Woltjen
        Liaison Laboratory Regular Seminar/HIGO Program Cutting-edge Seminar, 17 Feb. 2016, Invited
      • An epithelial program driven by KLF4 stoichiometry determines hallmarks of somatic cell reprogramming
        Knut Woltjen
        九州大学大学院医学研究院 第35回生命医科学セミナー, 16 Feb. 2016, Invited
      • At the Conflux of Genome Engineering and Pluripotent Stem Cell Biology
        Knut Woltjen
        Conference on Transposition and Genome Engineering 2015, 20 Nov. 2015, Invited
      • Engineering the Human Genome: Strategies for iPS Cell Derivation and Disease Modeling
        Knut Woltjen
        Wakate International Symposium “Discovery of Medical Sciences,” (WISDoMS), 06 Nov. 2014, Invited
      • From Transposons to Nucleases: Genome Engineering Strategies for iPS Cell Derivation and Disease Modeling
        Knut Woltjen
        The 71st of Stem Cell Biology and Regenerative Medicine Forum, 30 Jun. 2014, Invited
      • Recombinant DNA and Cell Technologies Enabling Human Functional Genomics
        Knut Woltjen
        Tokyo Tech Bio 2013, 29 Jan. 2014, Invited
      • Recombinant DNA and Cell Technologies Enabling Human Functional Genomics
        Knut Woltjen
        Department of Biological Sciences Molecules, Cells, and Systems Seminar Series (University of Alberta), 04 Nov. 2013, Invited
      • Transposed and targeted expression systems for guiding somatic cell reprogramming and differentiation
        Knut Woltjen
        Transposition and Genome Engineering 2013, Sep. 2013, Invited
      • Transposed and Targeted Gene Expression Systems for Guiding Somatic Cell Reprogramming and Differentiation
        Knut Woltjen
        46th Annual Meeting of the Japanese Society of Development Biologists, 31 May 2013, Invited
      • Cell Identity Transitions During Induced Reprogramming to Pluripotency
        Knut Woltjen
        The 7th Annual Meeting of the Japanese Society for Epigenetics, May 2013, Invited
      • Cell Identity Transitions During Induced Reprogramming to Pluripotency
        Knut Woltjen
        CDB Seminar, 29 Mar. 2013, Invited
      • Transposon Systems to Guiding Somatic Cell Reprogramming and Differentiation
        Knut Woltjen
        iCeMS-Stem Cells Australia Joint Symposium, 12 Feb. 2013, Invited

      Books and Other Publications

      • iPS細胞を用いた正確な ゲノム編集法(MhAX法)
        Harunobu Kagawa; Tomoko Matsumoto; Shin-Il Kim; Knut Woltjen, Contributor, pp. 1-8
        実験医学, Oct. 2018, Not refereed

      Industrial Property Rights

      • 特願PCT/IB2017/054736, Method for genome editing
        Knut Woltjen; Shin-Il Kim; Tomoko Matsumoto

      External funds: Kakenhi

      • 肺オルガノイドを用いた呼吸器病原体の革新的研究基盤の構築と病原性発現機序の解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 54030:Infectious disease medicine-related
        National Institute of Infectious Diseases
        酒井 宏治
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        SARS-CoV-2;インフルエンザウイルス;iPS細胞;肺オルガノイド;ゲノム編集
      • Evaluating the role of cis-regulatory tandem DNA repeats in human disease and evolution
        Grant-in-Aid for Scientific Research (B)
        Basic Section 43050:Genome biology-related
        Kyoto University
        ウォルツェン クヌート
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        DNAリピート;ゲノム編集;CRISPR-Cas9;iPS細胞;レポーターアッセイ
      • Developing a versatile technique to create transgenic rodents and medium sized animals
        Grant-in-Aid for Scientific Research (B)
        Basic Section 42040:Laboratory animal science-related
        Shiga University of Medical Science
        依馬 正次
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        トランスジェニック;トランスポザーゼ
      • Regulation of gene expression revealed by genome editing of repetitive and polymorphic cis-elements
        Grant-in-Aid for JSPS Fellows
        Basic Section 43050:Genome biology-related
        Kyoto University
        From 18 Nov. 2021, To 31 Mar. 2023, Granted
      • Establishment of universal iPS cells for regenerative medicine applications through regulated HLA expression
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Knut Woltjen
        From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
        Human leukocyte antigen;HLA;ゲノム編集;iPS細胞;CRISPR Cas9;KRAB;B2M;allograft;alloresponse;再生医療;ゲノム生物工学;個別化医療
      • CRISPR/Cas9 mediated identification of novel gene targets for XPA-associated skin cancer using in vitro reconstituted skin from iPS cells
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Fabian Oceguera-Yanez
        From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
        Human iPSCs;CRISPR/Cas9;Squamous Cell Carcinoma;Skin differentiation;Xeroderma pigmentosum
      • Induction of tendon/ligament progenitor cells from human iPSCs
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        CANTAS ALEV
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        Tendon Progenitor Cell;iPSCs;Mesoderm Differentiation;tendon progenitor cells;mesoderm differentiation;syndetome;Tendon Progenitor Cells;iPS細胞;腱誘導;中胚葉誘導;スクレラキシス;リポーター細胞
      • Single nucleotide-level genome engineering using transposon cassettes
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Knut WOLTJEN
        From 28 Apr. 2011, To 31 Mar. 2013, Project Closed
        遺伝子ターゲティング;ヌクレアーゼ;iPS細胞;TALEN nuclease;transposon;cardiomyocyte;SNP;ion channel;Gene targeting;CRISPR/Cas9 nuclease;iPS Cell;long QT-syndrome;TALEヌクレアーゼ;トランスポゾン
      • Molecular mechanisms underlying nuclear reprogramming of somatic cells
        Grant-in-Aid for Specially Promoted Research
        Biological Sciences
        Kyoto University
        Shinya YAMANAKA
        Project Closed
        再生医学;幹細胞;分化多能性;核初期化;転写因子

      External funds: others

      • Immediate Early Events in Reprogramming Leading to Cellular Plasticity
        From 2010, To 2012
      list
        Last Updated :2022/08/08

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Global Frontier in Life Science A
          1018, Spring, Graduate School of Biostudies, 2
        • From Apr. 2013, To Mar. 2014
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        • From Apr. 2014, To Mar. 2015
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        • From Apr. 2015, To Mar. 2016
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        • From Apr. 2016, To Mar. 2017
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        • From Apr. 2017, To Mar. 2018
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        • From Apr. 2018, To Mar. 2019
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        • From Apr. 2020, To Mar. 2021
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        • From Apr. 2021, To Mar. 2022
          Global Frontier in Life Science A
          Spring, 生命科学研究科
        list
          Last Updated :2022/08/08

          Administration

          Faculty management (title, position)

          • From 26 May 2022, To 31 Mar. 2024
            創薬技術開発室運営委員会
          • From 01 Apr. 2018, To 31 Mar. 2020
            組換えDNA実験安全委員会4号委員
          list
            Last Updated :2022/08/08

            Academic, Social Contribution

            Committee Memberships

            • From Jul. 2018, To Present
              International Committee, Japanese Society for Genome Editing
            • From Jul. 2018, To Present
              国際委員会委員, 日本ゲノム編集学会
            • From Jul. 2016, To Present
              Public Relations Committee, Japanese Society for Genome Editing
            • From Jul. 2016, To Present
              広報委員会委員, 日本ゲノム編集学会

            ページ上部へ戻る