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Kawamoto, Hiroshi

Institute for Life and Medical Sciences (LiMe) Professor

Kawamoto, Hiroshi
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    Last Updated :2022/08/06

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Medicine, 医学専攻 再生免疫学, 教授
    • Graduate School of Medicine, 医科学専攻 再生免疫学, 教授

    Concurrent Affiliation

    • Open Innovation Institute, 研究代表者

    Academic Degree

    • 博士(医学)(京都大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2022/08/06

      Research

      Research Interests

      • Hematology
      • Immunology

      Research Areas

      • Life sciences, Immunology

      Papers

      • Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.
        Rin Mizuno; Hiroaki Hojo; Masatomo Takahashi; Soshiro Kashio; Sora Enya; Motonao Nakao; Riyo Konishi; Mayuko Yoda; Ayano Harata; Junzo Hamanishi; Hiroshi Kawamoto; Masaki Mandai; Yutaka Suzuki; Masayuki Miura; Takeshi Bamba; Yoshihiro Izumi; Shinpei Kawaoka
        Nature communications, 15 Jun. 2022
      • カニクイザルの腫瘍浸潤T細胞から腫瘍殺傷能を有するTCR遺伝子を単離する
        近藤 健太; 寺田 晃士; 石垣 宏仁; 里岡 大樹; 永野 誠治; 増田 喬子; 平田 多佳子; 小笠原 一誠; 伊藤 靖; 河本 宏; 縣 保年
        日本がん免疫学会総会プログラム・抄録集, Sep. 2020
      • iPS技術を用いたNY-ESO-1特異的細胞傷害性T細胞の再生と成人T細胞性白血病および多発性骨髄腫治療への応用
        島津 裕; 前田 卓也; 永野 誠治; 島津 弥生; 菱澤 方勝; 石田 高司; 一瀬 大志; 増田 喬子; 直川 匡晴; 高折 晃史; 河本 宏
        日本リンパ網内系学会会誌, May 2017
      • iPS技術を用いたNY-ESO-1特異的細胞傷害性T細胞の再生と成人T細胞性白血病および多発性骨髄腫治療への応用
        島津 裕; 前田 卓也; 永野 誠治; 島津 弥生; 菱澤 方勝; 石田 高司; 一瀬 大志; 増田 喬子; 直川 匡晴; 高折 晃史; 河本 宏
        日本リンパ網内系学会会誌, May 2017
      • Isolation of TCR genes with tumor-killing activity from tumor-infiltrating and circulating lymphocytes in a tumor rejection cynomolgus macaque model.
        Koji Terada; Kenta Kondo; Hirohito Ishigaki; Ayaka Nagashima; Hiroki Satooka; Seiji Nagano; Kyoko Masuda; Teruhisa Kawamura; Takako Hirata; Kazumasa Ogasawara; Yasushi Itoh; Hiroshi Kawamoto; Yasutoshi Agata
        Molecular therapy oncolytics, 17 Mar. 2022, Peer-reviewed
      • A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia.
        Yukiko Kimura; Eisaku Iwanaga; Kouta Iwanaga; Shinya Endo; Yoshitaka Inoue; Kenji Tokunaga; Yousuke Nagahata; Kyoko Masuda; Hiroshi Kawamoto; Masao Matsuoka
        European journal of haematology, Mar. 2021
      • Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes.
        Takuya Maeda; Seiji Nagano; Soki Kashima; Koji Terada; Yasutoshi Agata; Hiroshi Ichise; Manami Ohtaka; Mahito Nakanishi; Fumihiro Fujiki; Haruo Sugiyama; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto
        Molecular therapy. Methods & clinical development, 11 Dec. 2020, Peer-reviewed
      • [Mass-Production of Cytotoxic T Lymphocytes Regenerated from Pluripotent Stem Cells-To Target Solid Tumors].
        Soki Kashima; Kyoko Masuda; Hiroshi Kawamoto
        Gan to kagaku ryoho. Cancer & chemotherapy, Oct. 2020
      • Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer
        Masayuki Nagasawa; Kosuke Tomimatsu; Koji Terada; Kenta Kondo; Kazuko Miyazaki; Masaki Miyazaki; Daisuke Motooka; Daisuke Okuzaki; Tetsuya Yoshida; Susumu Kageyama; Hiroshi Kawamoto; Akihiro Kawauchi; Yasutoshi Agata
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2020
      • Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.
        Soki Kashima; Takuya Maeda; Kyoko Masuda; Seiji Nagano; Takamitsu Inoue; Masashi Takeda; Yuka Kono; Takashi Kobayashi; Shigeyoshi Saito; Takahiro Higuchi; Hiroshi Ichise; Yuka Kobayashi; Keiko Iwaisako; Koji Terada; Yasutoshi Agata; Kazuyuki Numakura; Mitsuru Saito; Shintaro Narita; Masaki Yasukawa; Osamu Ogawa; Tomonori Habuchi; Hiroshi Kawamoto
        iScience, 24 Apr. 2020, Peer-reviewed
      • High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells.
        Seiji Nagano; Takuya Maeda; Hiroshi Ichise; Soki Kashima; Manami Ohtaka; Mahito Nakanishi; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto
        Molecular therapy. Methods & clinical development, 13 Mar. 2020, Peer-reviewed
      • Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells.
        Meghan L Good; Raul Vizcardo; Takuya Maeda; Naritaka Tamaoki; Parisa Malekzadeh; Hiroshi Kawamoto; Nicholas P Restifo
        Journal of visualized experiments : JoVE, 24 Oct. 2019, Peer-reviewed
      • Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection.
        Miki Arai Hojo; Kyoko Masuda; Hiroaki Hojo; Yosuke Nagahata; Keiko Yasuda; Daiya Ohara; Yusuke Takeuchi; Keiji Hirota; Yutaka Suzuki; Hiroshi Kawamoto; Shinpei Kawaoka
        Nature communications, 13 Jun. 2019, Peer-reviewed
      • Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.
        Takahito Minami; Takamichi Ishii; Kentaro Yasuchika; Ken Fukumitsu; Satoshi Ogiso; Yuya Miyauchi; Hidenobu Kojima; Takayuki Kawai; Ryoya Yamaoka; Yu Oshima; Hiroshi Kawamoto; Maki Kotaka; Katsutaro Yasuda; Kenji Osafune; Shinji Uemoto
        Regenerative therapy, Jun. 2019, Peer-reviewed
      • Optimal use of antiplatelet agents, especially aspirin, in the perioperative management of colorectal cancer patients undergoing laparoscopic colorectal resection.
        Yoshimoto Y; Fujikawa T; Tanaka A; Hayashi H; Shimoike N; Kawamoto H; Nakasuga C; Yamamoto T
        World journal of surgical oncology, Jun. 2019, Peer-reviewed
      • Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.
        Bo Gong; Kazuma Kiyotani; Seiji Sakata; Seiji Nagano; Shun Kumehara; Satoko Baba; Benjamin Besse; Noriko Yanagitani; Luc Friboulet; Makoto Nishio; Kengo Takeuchi; Hiroshi Kawamoto; Naoya Fujita; Ryohei Katayama
        The Journal of experimental medicine, 01 Apr. 2019, Peer-reviewed
      • Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice.
        Junko Masuda; Eiji Takayama; Tatsuo Ichinohe; Warren Strober; Masako Mizuno-Kamiya; Tomokatsu Ikawa; Atsushi Kitani; Harumi Kawaki; Ivan Fuss; Hiroshi Kawamoto; Akimasa Seno; Arun Vaidyanath; Naoki Umemura; Akifumi Mizutani; Tomonari Kasai; Yasuko Honjo; Ayano Satoh; Hiroshi Murakami; Yoshimoto Katsura; Nobuo Kondoh; Masaharu Seno
        Experimental and therapeutic medicine, Nov. 2018, Peer-reviewed
      • Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors
        Mari Tenno; Satoshi Kojo; Divine-Fondzenyuy Lawir; Isabell Hess; Katsuyuki Shiroguchi; Takashi Ebihara; Takaho A. Endo; Sawako Muroi; Rumi Satoh; Hiroshi Kawamoto; Thomas Boehm; Ichiro Taniuchi
        Journal of Experimental Medicine, 01 Feb. 2018, Peer-reviewed
      • Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells
        Tomohiro Miyai; Junichiro Takano; Takaho A. Endo; Eiryo Kawakami; Yasutoshi Agata; Yasutaka Motomura; Masato Kubo; Yukie Kashima; Yutaka Suzuki; Hiroshi Kawamoto; Tomokatsu Ikawa
        Genes and Development, 15 Jan. 2018, Peer-reviewed
      • NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs
        Hiroshi Ichise; Seiji Nagano; Takuya Maeda; Masaki Miyazaki; Yuki Miyazaki; Hiroto Kojima; Nobuyo Yawata; Makoto Yawata; Hidenori Tanaka; Hiroh Saji; Kyoko Masuda; Hiroshi Kawamoto
        STEM CELL REPORTS, Sep. 2017, Peer-reviewed
      • FANTOM5 CAGE profiles of human and mouse samples.
        Shuhei Noguchi; Takahiro Arakawa; Shiro Fukuda; Masaaki Furuno; Akira Hasegawa; Fumi Hori; Sachi Ishikawa-Kato; Kaoru Kaida; Ai Kaiho; Mutsumi Kanamori-Katayama; Tsugumi Kawashima; Miki Kojima; Atsutaka Kubosaki; Ri-Ichiroh Manabe; Mitsuyoshi Murata; Sayaka Nagao-Sato; Kenichi Nakazato; Noriko Ninomiya; Hiromi Nishiyori-Sueki; Shohei Noma; Eri Saijyo; Akiko Saka; Mizuho Sakai; Christophe Simon; Naoko Suzuki; Michihira Tagami; Shoko Watanabe; Shigehiro Yoshida; Peter Arner; Richard A Axton; Magda Babina; J Kenneth Baillie; Timothy C Barnett; Anthony G Beckhouse; Antje Blumenthal; Beatrice Bodega; Alessandro Bonetti; James Briggs; Frank Brombacher; Ailsa J Carlisle; Hans C Clevers; Carrie A Davis; Michael Detmar; Taeko Dohi; Albert S B Edge; Matthias Edinger; Anna Ehrlund; Karl Ekwall; Mitsuhiro Endoh; Hideki Enomoto; Afsaneh Eslami; Michela Fagiolini; Lynsey Fairbairn; Mary C Farach-Carson; Geoffrey J Faulkner; Carmelo Ferrai; Malcolm E Fisher; Lesley M Forrester; Rie Fujita; Jun-Ichi Furusawa; Teunis B Geijtenbeek; Thomas Gingeras; Daniel Goldowitz; Sven Guhl; Reto Guler; Stefano Gustincich; Thomas J Ha; Masahide Hamaguchi; Mitsuko Hara; Yuki Hasegawa; Meenhard Herlyn; Peter Heutink; Kelly J Hitchens; David A Hume; Tomokatsu Ikawa; Yuri Ishizu; Chieko Kai; Hiroshi Kawamoto; Yuki I Kawamura; Judith S Kempfle; Tony J Kenna; Juha Kere; Levon M Khachigian; Toshio Kitamura; Sarah Klein; S Peter Klinken; Alan J Knox; Soichi Kojima; Haruhiko Koseki; Shigeo Koyasu; Weonju Lee; Andreas Lennartsson; Alan Mackay-Sim; Niklas Mejhert; Yosuke Mizuno; Hiromasa Morikawa; Mitsuru Morimoto; Kazuyo Moro; Kelly J Morris; Hozumi Motohashi; Christine L Mummery; Yutaka Nakachi; Fumio Nakahara; Toshiyuki Nakamura; Yukio Nakamura; Tadasuke Nozaki; Soichi Ogishima; Naganari Ohkura; Hiroshi Ohno; Mitsuhiro Ohshima; Mariko Okada-Hatakeyama; Yasushi Okazaki; Valerio Orlando; Dmitry A Ovchinnikov; Robert Passier; Margaret Patrikakis; Ana Pombo; Swati Pradhan-Bhatt; Xian-Yang Qin; Michael Rehli; Patrizia Rizzu; Sugata Roy; Antti Sajantila; Shimon Sakaguchi; Hiroki Sato; Hironori Satoh; Suzana Savvi; Alka Saxena; Christian Schmidl; Claudio Schneider; Gundula G Schulze-Tanzil; Anita Schwegmann; Guojun Sheng; Jay W Shin; Daisuke Sugiyama; Takaaki Sugiyama; Kim M Summers; Naoko Takahashi; Jun Takai; Hiroshi Tanaka; Hideki Tatsukawa; Andru Tomoiu; Hiroo Toyoda; Marc van de Wetering; Linda M van den Berg; Roberto Verardo; Dipti Vijayan; Christine A Wells; Louise N Winteringham; Ernst Wolvetang; Yoko Yamaguchi; Masayuki Yamamoto; Chiyo Yanagi-Mizuochi; Misako Yoneda; Yohei Yonekura; Peter G Zhang; Silvia Zucchelli; Imad Abugessaisa; Erik Arner; Jayson Harshbarger; Atsushi Kondo; Timo Lassmann; Marina Lizio; Serkan Sahin; Thierry Sengstag; Jessica Severin; Hisashi Shimoji; Masanori Suzuki; Harukazu Suzuki; Jun Kawai; Naoto Kondo; Masayoshi Itoh; Carsten O Daub; Takeya Kasukawa; Hideya Kawaji; Piero Carninci; Alistair R R Forrest; Yoshihide Hayashizaki
        Scientific data, 29 Aug. 2017, Peer-reviewed
      • Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
        Masafumi Seki; Shunsuke Kimura; Tomoya Isobe; Kenichi Yoshida; Hiroo Ueno; Yaeko Nakajima-Takagi; Changshan Wang; Lin Lin; Ayana Kon; Hiromichi Suzuki; Yusuke Shiozawa; Keisuke Kataoka; Yoichi Fujii; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Teppei Shimamura; Kyoko Masuda; Hiroshi Kawamoto; Kentaro Ohki; Motohiro Kato; Yuki Arakawa; Katsuyoshi Koh; Ryoji Hanada; Hiroshi Moritake; Masaharu Akiyama; Ryoji Kobayashi; Takao Deguchi; Yoshiko Hashii; Toshihiko Imamura; Atsushi Sato; Nobutaka Kiyokawa; Akira Oka; Yasuhide Hayashi; Masatoshi Takagi; Atsushi Manabe; Akira Ohara; Keizo Horibe; Masashi Sanada; Atsushi Iwama; Hiroyuki Mano; Satoru Miyano; Seishi Ogawa; Junko Takita
        NATURE GENETICS, Aug. 2017, Peer-reviewed
      • The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development
        Masaki Miyazaki; Kazuko Miyazaki; Kenian Chen; Yi Jin; Jacob Turner; Amanda J. Moore; Rintaro Saito; Kenichi Yoshida; Seishi Ogawa; Hans-Reimer Rodewald; Yin C. Lin; Hiroshi Kawamoto; Cornelis Murre
        IMMUNITY, May 2017, Peer-reviewed
      • Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting
        Junko Masuda; Hiroshi Kawamoto; Warren Strober; Eiji Takayama; Akifumi Mizutani; Hiroshi Murakami; Tomokatsu Ikawa; Atsushi Kitani; Narumi Maeno; Tsukasa Shigehiro; Ayano Satoh; Akimasa Seno; Vaidyanath Arun; Tomonari Kasai; Ivan J. Fuss; Yoshimoto Katsura; Masaharu Seno
        APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, Dec. 2016, Peer-reviewed
      • Regeneration of CD8 alpha beta T Cells from T-cell-Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity
        Takuya Maeda; Seiji Nagano; Hiroshi Ichise; Keisuke Kataoka; Daisuke Yamada; Seishi Ogawa; Haruhiko Koseki; Toshio Kitawaki; Norimitsu Kadowaki; Akifumi Takaori-Kondo; Kyoko Masuda; Hiroshi Kawamoto
        CANCER RESEARCH, Dec. 2016, Peer-reviewed
      • Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program
        Tomokatsu Ikawa; Kyoko Masuda; Takaho A. Endo; Mitsuhiro Endo; Kyoichi Isono; Yoko Koseki; Rinako Nakagawa; Kohei Kometani; Junichiro Takano; Yasutoshi Agata; Yoshimoto Katsura; Tomohiro Kurosaki; Miguel Vidal; Haruhiko Koseki; Hiroshi Kawamoto
        GENES & DEVELOPMENT, Nov. 2016, Peer-reviewed
      • Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.
        Yuki Sato; Akiko Mii; Yoko Hamazaki; Harumi Fujita; Hirosuke Nakata; Kyoko Masuda; Shingo Nishiyama; Shinsuke Shibuya; Hironori Haga; Osamu Ogawa; Akira Shimizu; Shuh Narumiya; Tsuneyasu Kaisho; Makoto Arita; Masashi Yanagisawa; Masayuki Miyasaka; Kumar Sharma; Nagahiro Minato; Hiroshi Kawamoto; Motoko Yanagita
        JCI insight, 21 Jul. 2016, Peer-reviewed
      • Aberrant PD-L1 expression through 3 '-UTR disruption in multiple cancers
        Keisuke Kataoka; Yuichi Shiraishi; Yohei Takeda; Seiji Sakata; Misako Matsumoto; Seiji Nagano; Takuya Maeda; Yasunobu Nagata; Akira Kitanaka; Seiya Mizuno; Hiroko Tanaka; Kenichi Chiba; Satoshi Ito; Yosaku Watatani; Nobuyuki Kakiuchi; Hiromichi Suzuki; Tetsuichi Yoshizato; Kenichi Yoshida; Masashi Sanada; Hidehiro Itonaga; Yoshitaka Imaizumi; Yasushi Totoki; Wataru Munakata; Hiromi Nakamura; Natsuko Hama; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Takuro Kameda; Kyoko Masuda; Nagahiro Minato; Koichi Kashiwase; Koji Izutsu; Akifumi Takaori-Kondo; Yasushi Miyazaki; Satoru Takahashi; Tatsuhiro Shibata; Hiroshi Kawamoto; Yoshiki Akatsuka; Kazuya Shimoda; Kengo Takeuchi; Tsukasa Seya; Satoru Miyano; Seishi Ogawa
        NATURE, Jun. 2016, Peer-reviewed
      • Generation and regeneration of T cells
        Hiroshi Kawamoto; Tomokatsu Ikawa; Takuya Maeda; Kyoko Masuda
        Synthetic Immunology, 01 Jan. 2016, Peer-reviewed
      • Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells
        Rumi Satoh; Kiyokazu Kakugawa; Takuwa Yasuda; Hisahiro Yoshida; Maria Sibilia; Yoshimoto Katsura; Ben Levi; Jakub Abramson; Yoko Koseki; Haruhiko Koseki; Willem van Ewijk; Georg A. Hollander; Hiroshi Kawamoto
        PLOS GENETICS, Jan. 2016, Peer-reviewed
      • Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells
        Tomokatsu Ikawa; Kyoko Masuda; Mirelle J. A. J. Huijskens; Rumi Satoh; Kiyokazu Kakugawa; Yasutoshi Agata; Tomohiro Miyai; Wilfred T. V. Germeraad; Yoshimoto Katsura; Hiroshi Kawamoto
        STEM CELL REPORTS, Nov. 2015, Peer-reviewed
      • BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells
        Tomohiro Iguchi; Kazuhisa Aoki; Tomokatsu Ikawa; Masato Taoka; Choji Taya; Hiroshi Yoshitani; Makiko Toma-Hirano; Osamu Koiwai; Toshiaki Isobe; Hiroshi Kawamoto; Hisao Masai; Shoichiro Miyatake
        JOURNAL OF IMMUNOLOGY, Aug. 2015, Peer-reviewed
      • CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability
        Takeshi Inoue; Masahiro Morita; Atsushi Hijikata; Yoko Fukuda-Yuzawa; Shungo Adachi; Kyoichi Isono; Tomokatsu Ikawa; Hiroshi Kawamoto; Haruhiko Koseki; Tohru Natsume; Taro Fukao; Osamu Ohara; Tadashi Yamamoto; Tomohiro Kurosaki
        JOURNAL OF EXPERIMENTAL MEDICINE, Aug. 2015, Peer-reviewed
      • Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
        Erik Arner; Carsten O. Daub; Kristoffer Vitting-Seerup; Robin Andersson; Berit Lilje; Finn Drablos; Andreas Lennartsson; Michelle Roennerblad; Olga Hrydziuszko; Morana Vitezic; Tom C. Freeman; Ahmad M. N. Alhendi; Peter Arner; Richard Axton; J. Kenneth Baillie; Anthony Beckhouse; Beatrice Bodega; James Briggs; Frank Brombacher; Margaret Davis; Michael Detmar; Anna Ehrlund; Mitsuhiro Endoh; Afsaneh Eslami; Michela Fagiolini; Lynsey Fairbairn; Geoffrey J. Faulkner; Carmelo Ferrai; Malcolm E. Fisher; Lesley Forrester; Daniel Goldowitz; Reto Guler; Thomas Ha; Mitsuko Hara; Meenhard Herlyn; Tomokatsu Ikawa; Chieko Kai; Hiroshi Kawamoto; Levon M. Khachigian; S. Peter Klinken; Soichi Kojima; Haruhiko Koseki; Sarah Klein; Niklas Mejhert; Ken Miyaguchi; Yosuke Mizuno; Mitsuru Morimoto; Kelly J. Morris; Christine Mummery; Yutaka Nakachi; Soichi Ogishima; Mariko Okada-Hatakeyama; Yasushi Okazaki; Valerio Orlando; Dmitry Ovchinnikov; Robert Passier; Margaret Patrikakis; Ana Pombo; Xian-Yang Qin; Sugata Roy; Hiroki Sato; Suzana Savvi; Alka Saxena; Anita Schwegmann; Daisuke Sugiyama; Rolf Swoboda; Hiroshi Tanaka; Andru Tomoiu; Louise N. Winteringham; Ernst Wolvetang; Chiyo Yanagi-Mizuochi; Misako Yoneda; Susan Zabierowski; Peter Zhang; Imad Abugessaisa; Nicolas Bertin; Alexander D. Diehl; Shiro Fukuda; Masaaki Furuno; Jayson Harshbarger; Akira Hasegawa; Fumi Hori; Sachi Ishikawa-Kato; Yuri Ishizu; Masayoshi Itoh; Tsugumi Kawashima; Miki Kojima; Naoto Kondo; Marina Lizio; Terrence F. Meehan; Christopher J. Mungall; Mitsuyoshi Murata; Hiromi Nishiyori-Sueki; Serkan Sahin; Sayaka Nagao-Sato; Jessica Severin; Michiel J. L. de Hoon; Jun Kawai; Takeya Kasukawa; Timo Lassmann; Harukazu Suzuki; Hideya Kawaji; Kim M. Summers; Christine Wells; David A. Hume; Alistair R. R. Forrest; Albin Sandelin; Piero Carninci; Yoshihide Hayashizaki
        SCIENCE, Feb. 2015, Peer-reviewed
      • The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant T-FH cell development, thymocyte expansion, and lymphomagenesis
        Masaki Miyazaki; Kazuko Miyazaki; Shuwen Chen; Vivek Chandra; Keisuke Wagatsuma; Yasutoshi Agata; Hans-Reimer Rodewald; Rintaro Saito; Aaron N. Chang; Nissi Varki; Hiroshi Kawamoto; Cornelis Murre
        GENES & DEVELOPMENT, Feb. 2015, Peer-reviewed
      • Indication for neoadjuvant chemotherapy in patients with colorectal liver metastases based on a nomogram that predicts disease-free survival
        Masayuki Okuno; Etsuro Hatano; Satoru Seo; Kojiro Taura; Kentaro Yasuchika; Akio Nakajima; Takefumi Yazawa; Hiroaki Furuyama; Hiroshi Kawamoto; Shintaro Yagi; Ryuta Nishitai; Takahisa Fujikawa; Akira Arimoto; Masazumi Zaima; Tsunehiro Yoshimura; Hiroaki Terajima; Satoshi Kaihara; Dai Manaka; Akira Tanaka; Shinji Uemoto
        JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Dec. 2014, Peer-reviewed
      • TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells
        Farrah C. Steinke; Shuyang Yu; Xinyuan Zhou; Bing He; Wenjing Yang; Bo Zhou; Hiroshi Kawamoto; Jun Zhu; Kai Tan; Hai-Hui Xue
        NATURE IMMUNOLOGY, Jul. 2014, Peer-reviewed
      • Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells
        Takayuki Hoshii; Atsuo Kasada; Tomoki Hatakeyama; Masashi Ohtani; Yuko Tadokoro; Kazuhito Naka; Tsuneo Ikenoue; Tomokatsu Ikawa; Hiroshi Kawamoto; Hans Joerg Fehling; Kimi Araki; Ken-ichi Yamamura; Satoshi Matsuda; Atsushi Hirao
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2014, Peer-reviewed
      • mTORC1 Inactivation Prevents and Eradicates Acute Lymphoblastic T-Cell Leukemia
        Takayuki Hoshii; Atsuo Kasada; Tomoki Hatakeyama; Masashi Ohtani; Yuko Tadokoro; Kazuhito Naka; Tsuneo Ikenoue; Tomokatsu Ikawa; Hiroshi Kawamoto; Kimi Araki; Ken-ichi Yamamura; Atsushi Iwama; Satoshi Matsuda; Atsushi Hirao
        BLOOD, Nov. 2013, Peer-reviewed
      • Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages
        Takamasa Katagiri; Hiroshi Kawamoto; Takashi Nakakuki; Ken Ishiyama; Mariko Okada-Hatakeyama; Shigeki Ohtake; Yu Seiki; Kohei Hosokawa; Shinji Nakao
        Stem Cells, Mar. 2013, Peer-reviewed
      • Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8(+) T Cells
        Raul Vizcardo; Kyoko Masuda; Daisuke Yamada; Tomokatsu Ikawa; Kanako Shimizu; Shin-ichiro Fujii; Haruhiko Koseki; Hiroshi Kawamoto
        CELL STEM CELL, Jan. 2013, Peer-reviewed
      • Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8(+) T Cells
        Raul Vizcardo; Kyoko Masuda; Daisuke Yamada; Tomokatsu Ikawa; Kanako Shimizu; Shin-ichiro Fujii; Haruhiko Koseki; Hiroshi Kawamoto
        CELL STEM CELL, Jan. 2013, Peer-reviewed
      • Generation of Melanoma Antigen Specific T Cells From Human Ips Cells Using a Feeder Free System
        Vizcardo Raul; Masuda Kyoko; Yamada Daisuke; Ikawa Tomokatsu; Shimizu Kanako; Fujii Shin-ichiro; Koseki Haruhiko; Kawamoto Hiroshi
        BLOOD, 16 Nov. 2012, Peer-reviewed
      • Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM
        Takeshi Isoda; Masatoshi Takagi; Jinhua Piao; Shun Nakagama; Masaki Sato; Kyoko Masuda; Tomokatsu Ikawa; Miyuki Azuma; Tomohiro Morio; Hiroshi Kawamoto; Shuki Mizutani
        Blood, 26 Jul. 2012, Peer-reviewed
      • Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM
        Takeshi Isoda; Masatoshi Takagi; Jinhua Piao; Shun Nakagama; Masaki Sato; Kyoko Masuda; Tomokatsu Ikawa; Miyuki Azuma; Tomohiro Morio; Hiroshi Kawamoto; Shuki Mizutani
        BLOOD, Jul. 2012, Peer-reviewed
      • Runx1-Cbf beta facilitates early B lymphocyte development by regulating expression of Ebf1
        Wooseok Seo; Tomokatsu Ikawa; Hiroshi Kawamoto; Ichiro Taniuchi
        JOURNAL OF EXPERIMENTAL MEDICINE, Jul. 2012, Peer-reviewed
      • Development and Function of Invariant Natural Killer T Cells Producing T(H)2- and T(H)17-Cytokines
        Hiroshi Watarai; Etsuko Sekine-Kondo; Tomokuni Shigeura; Yasutaka Motomura; Takuwa Yasuda; Rumi Satoh; Hisahiro Yoshida; Masato Kubo; Hiroshi Kawamoto; Haruhiko Koseki; Masaru Taniguchi
        PLOS BIOLOGY, Feb. 2012, Peer-reviewed
      • Development and Function of Invariant Natural Killer T Cells Producing T(H)2- and T(H)17-Cytokines
        Hiroshi Watarai; Etsuko Sekine-Kondo; Tomokuni Shigeura; Yasutaka Motomura; Takuwa Yasuda; Rumi Satoh; Hisahiro Yoshida; Masato Kubo; Hiroshi Kawamoto; Haruhiko Koseki; Masaru Taniguchi
        PLOS BIOLOGY, Feb. 2012, Peer-reviewed
      • E2A-HLFキメラ転写因子によるLMO2誘導異常と、t(17:19)を持つB前駆細胞性ALLの白血病誘発におけるその意味(Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursorALL with t(17:19))
        廣瀬 衣子; 犬飼 岳史; 菊池 次郎; 古川 雄祐; 伊川 友活; 河本 宏; Oram S. Helen; Goettgens Berthold; 清河 信敬; 宮川 世志幸; 大喜多 肇; 赤羽 弘資; 張 暁春; 黒田 格; 大城 浩子[本名]; 加賀美 恵子; 合井 久美子; 黒澤 秀光; Look A. Thomas; 松井 啓隆; 稲葉 俊哉; 杉田 完爾
        小児がん, Nov. 2011
      • Notch-Hes1 pathway is required for the development of IL-17-producing gamma delta T cells
        Kensuke Shibata; Hisakata Yamada; Tetsuya Sato; Takashi Dejima; Masataka Nakamura; Tomokatsu Ikawa; Hiromitsu Hara; Sho Yamasaki; Ryoichiro Kageyama; Yoichiro Iwakura; Hiroshi Kawamoto; Hiroyuki Toh; Yasunobu Yoshikai
        BLOOD, Jul. 2011, Peer-reviewed
      • Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells
        Yun Guo; Masaki Miyazaki; Manami Itoi; Rumi Satoh; Atsushi Iwama; Takashi Amagai; Hiroshi Kawamoto; Masamoto Kanno
        EUROPEAN JOURNAL OF IMMUNOLOGY, Apr. 2011, Peer-reviewed
      • miR-126はB細胞分化を誘導する(miR-126 induce B cell differentiation)
        幸谷 愛; ハーンプラソワット・ラタナカニット; 山下 理宇; 豊嶋 孝恵; 伊川 友活; 河本 宏; 東條 有伸
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010
      • The Role of the Basic Helix-Loop-Helix Transcription Factor Dec1 in the Regulatory T Cells
        Kazuko Miyazaki; Masaki Miyazaki; Yun Guo; Norimasa Yamasaki; Masamoto Kanno; Zen-ichiro Honda; Hideaki Oda; Hiroshi Kawamoto; Hiroaki Honda
        JOURNAL OF IMMUNOLOGY, Dec. 2010, Peer-reviewed
      • A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model.
        Hiroshi Kawamoto; Tomokatsu Ikawa; Kyoko Masuda; Haruka Wada; Yoshimoto Katsura
        Immunological reviews, Nov. 2010
      • Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)
        Kinuko Hirose; Takeshi Inukai; Jiro Kikuchi; Yusuke Furukawa; Tomokatsu Ikawa; Hiroshi Kawamoto; S. Helen Oram; Berthold Goettgens; Nobutaka Kiyokawa; Yoshitaka Miyagawa; Hajime Okita; Koshi Akahane; Xiaochun Zhang; Itaru Kuroda; Hiroko Honna; Keiko Kagami; Kumiko Goi; Hidemitsu Kurosawa; A. Thomas Look; Hirotaka Matsui; Toshiya Inaba; Kanji Sugita
        BLOOD, Aug. 2010, Peer-reviewed
      • An Essential Developmental Checkpoint for Production of the T Cell Lineage
        Tomokatsu Ikawa; Satoshi Hirose; Kyoko Masuda; Kiyokazu Kakugawa; Rumi Satoh; Asako Shibano-Satoh; Ryo Kominami; Yoshimoto Katsura; Hiroshi Kawamoto
        SCIENCE, Jul. 2010, Peer-reviewed
      • Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
        Yumiko Nishikawa; Fumiko Hirota; Masashi Yano; Hiroyuki Kitajima; Jun-ichi Miyazaki; Hiroshi Kawamoto; Yasuhiro Mouri; Mitsuru Matsumoto
        JOURNAL OF EXPERIMENTAL MEDICINE, May 2010, Peer-reviewed
      • Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1
        Hideyuki Oguro; Jin Yuan; Hitoshi Ichikawa; Tonnokatsu Ikawa; Satoshi Yamazaki; Hiroshi Kawamoto; Hiromitsu Nakauchi; Atsushi Iwama
        CELL STEM CELL, Mar. 2010, Peer-reviewed
      • Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1
        Hideyuki Oguro; Jin Yuan; Hitoshi Ichikawa; Tonnokatsu Ikawa; Satoshi Yamazaki; Hiroshi Kawamoto; Hiromitsu Nakauchi; Atsushi Iwama
        CELL STEM CELL, Mar. 2010, Peer-reviewed
      • A revised scheme for developmental pathways of hematopoietic cells: the myeloid-based model
        Hiroshi Kawamoto; Haruka Wada; Yoshimoto Katsura
        INTERNATIONAL IMMUNOLOGY, Feb. 2010, Peer-reviewed
      • Thymic cysts originate from Foxn1 positive thymic medullary epithelium
        Eric Vroegindeweij; Stijn Crobach; Manami Itoi; Rumi Satoh; Saulius Zuklys; Christiane Happe; Wilfred T. V. Germeraad; Jan J. Cornelissen; Tom Cupedo; Georg A. Hollander; Hiroshi Kawamoto; Willem van Ewijk
        MOLECULAR IMMUNOLOGY, Feb. 2010, Peer-reviewed
      • Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant V alpha 14-J alpha 18 TCR alpha gene
        Hiroshi Watarai; Andrei Rybouchkin; Naomi Hongo; Yuko Nagata; Sakura Sakata; Etsuko Sekine; Nyambayar Dashtsoodol; Takuya Tashiro; Shin-ichiro Fujii; Kanako Shimizu; Kenji Mori; Kyoko Masuda; Hiroshi Kawamoto; Haruhiko Koseki; Masaru Taniguchi
        BLOOD, Jan. 2010, Peer-reviewed
      • In vitro human G-CSF mobilized CD34 + derived T-cell progenitors fully mature in vivo
        Meek B; S Cloosen; C Borsotti; J Van Elssen; J Vanderlocht; M Schnijderberg; M van der Poel; B Leewis; R Hesselink; M G Manz; Y Katsura; H Kawamoto; W TV Germeraad; G MJ Bos
        Blood, 2010, Peer-reviewed
      • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
        Kazuyo Moro; Taketo Yamada; Masanobu Tanabe; Tsutomu Takeuchi; Tomokatsu Ikawa; Hiroshi Kawamoto; Jun-ichi Furusawa; Masashi Ohtani; Hideki Fujii; Shigeo Koyasu
        NATURE, Jan. 2010, Peer-reviewed
      • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
        Kazuyo Moro; Taketo Yamada; Masanobu Tanabe; Tsutomu Takeuchi; Tomokatsu Ikawa; Hiroshi Kawamoto; Jun-ichi Furusawa; Masashi Ohtani; Hideki Fujii; Shigeo Koyasu
        NATURE, Jan. 2010, Peer-reviewed
      • In vitro-differentiated T/natural killer-cell progenitors derived from human CD34(+) cells mature in the thymus
        Bob Meek; Silvie Cloosen; Chiara Borsotti; Catharina H. M. J. Van Elssen; Joris Vanderlocht; Melanie C. A. Schnijderberg; Marjolein W. M. van der Poel; Bas Leewis; Reinout Hesselink; Markus G. Manz; Yoshimoto Katsura; Hiroshi Kawamoto; Wilfred T. V. Germeraad; Gerard M. J. Bos
        BLOOD, Jan. 2010, Peer-reviewed
      • Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant V alpha 14-J alpha 18 TCR alpha gene
        Hiroshi Watarai; Andrei Rybouchkin; Naomi Hongo; Yuko Nagata; Sakura Sakata; Etsuko Sekine; Nyambayar Dashtsoodol; Takuya Tashiro; Shin-ichiro Fujii; Kanako Shimizu; Kenji Mori; Kyoko Masuda; Hiroshi Kawamoto; Haruhiko Koseki; Masaru Taniguchi
        BLOOD, Jan. 2010, Peer-reviewed
      • Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses.
        Michiyo Imada; Kyoko Masuda; Rumi Satoh; Yumi Ito; Yoshiyuki Goto; Takayuki Matsuoka; Shota Endo; Akira Nakamura; Hiroshi Kawamoto; Toshiyuki Takai
        International immunology, Oct. 2009, Peer-reviewed
      • A Novel Gene Essential for the Development of Single Positive Thymocytes
        Kiyokazu Kakugawa; Takuwa Yasuda; Ikuo Miura; Ayako Kobayashi; Hitomi Fukiage; Rumi Satoh; Masashi Matsuda; Haruhiko Koseki; Shigeharu Wakana; Hiroshi Kawamoto; Hisahiro Yoshida
        MOLECULAR AND CELLULAR BIOLOGY, Sep. 2009, Peer-reviewed
      • Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreER(T2)
        Atsuko Yoshioka Higashi; Tomokatsu Ikawa; Masamichi Muramatsu; Aris N. Economides; Akira Niwa; Tomohiko Okuda; Andrew J. Murphy; Jose Rojas; Toshio Heike; Tatsutoshi Nakahata; Hiroshi Kawamoto; Toru Kita; Motoko Yanagita
        JOURNAL OF IMMUNOLOGY, May 2009, Peer-reviewed
      • A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy
        Hiroshi Kawamoto; Yoshimoto Katsura
        TRENDS IN IMMUNOLOGY, May 2009, Peer-reviewed
      • The Global Thymus Network: past, present and future
        Yousuke Takahama; Takashi Saito; Hiroshi Kawamoto; Manami Itoi; Richard L. Boyd; Ann Chidgey; Rose Zamoyska; Georg A. Hollaender; Graham Anderson; Naomi Taylor; Howard T. Petrie; Janko Nikolich-Zugich
        TRENDS IN IMMUNOLOGY, May 2009, Peer-reviewed
      • Notch activation in thymic epithelial cells induces development of thymic microenvironments
        Kyoko Masuda; Wilfred T. V. Germeraad; Rumi Satoh; Manami Itoi; Tomokatsu Ikawa; Nagahiro Minato; Yoshimoto Katsura; Willem van Ewijk; Hiroshi Kawamoto
        MOLECULAR IMMUNOLOGY, May 2009, Peer-reviewed
      • Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage
        Satoshi Komaniwa; Hiroshi Hayashi; Hiroshi Kawamota; Satoshi B. Sato; Tomokatsu Ikawa; Yoshimoto Katsura; Keiko Udaka
        EUROPEAN JOURNAL OF IMMUNOLOGY, Jan. 2009, Peer-reviewed
      • Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
        Masashi Yano; Noriyuki Kuroda; Hongwei Han; Makiko Meguro-Horike; Yumiko Nishikawa; Hiroshi Kiyonari; Kentaro Maemura; Yuchio Yanagawa; Kunihiko Obata; Satoru Takahashi; Tomokatsu Ikawa; Rumi Satoh; Hiroshi Kawamoto; Yasuhiro Mouri; Mitsuru Matsumoto
        JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 2008, Peer-reviewed
      • Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
        Masashi Yano; Noriyuki Kuroda; Hongwei Han; Makiko Meguro-Horike; Yumiko Nishikawa; Hiroshi Kiyonari; Kentaro Maemura; Yuchio Yanagawa; Kunihiko Obata; Satoru Takahashi; Tomokatsu Ikawa; Rumi Satoh; Hiroshi Kawamoto; Yasuhiro Mouri; Mitsuru Matsumoto
        JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 2008, Peer-reviewed
      • Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
        Sawako Muroi; Yoshinori Naoe; Chizuko Miyamoto; Kaori Akiyama; Tomokatsu Ikawa; Kyoko Masuda; Hiroshi Kawamoto; Ichiro Taniuchi
        NATURE IMMUNOLOGY, Oct. 2008, Peer-reviewed
      • Adult T-cell progenitors retain myeloid potential
        Haruka Wada; Kyoko Masuda; Rumi Satoh; Kiyokazu Kakugawa; Tomokatsu Ikawa; Yoshimoto Katsura; Hiroshi Kawamoto
        NATURE, Apr. 2008, Peer-reviewed
      • Protein phosphatase subunit G5PR that regulates the JNK-mediated apoptosis signal is essential for the survival of CD4 and CD8 double-positive thymocytes
        Yan Xing; Xiaodan Wang; Hideya Igarashi; Hiroshi Kawamoto; Nobuo Sakaguchi
        MOLECULAR IMMUNOLOGY, Apr. 2008, Peer-reviewed
      • Thymocyte proliferation induced by pre-t cell receptor signaling is maintained through polycomb gene product bmi-1-mediated Cdkn2a repression
        Masaki Miyazaki; Kazuko Miyazaki; Manarni Itoi; Yuko Katoh; Yun Guo; Rieko Kanno; Yuko Katoh-Fukui; Hiroaki Honda; Takashi Amagai; Maarten van Lohuizen; Hiroshi Kawamoto; Masamoto Kanno
        IMMUNITY, Feb. 2008, Peer-reviewed
      • Thymocyte proliferation induced by pre-t cell receptor signaling is maintained through polycomb gene product bmi-1-mediated Cdkn2a repression
        Masaki Miyazaki; Kazuko Miyazaki; Manarni Itoi; Yuko Katoh; Yun Guo; Rieko Kanno; Yuko Katoh-Fukui; Hiroaki Honda; Takashi Amagai; Maarten van Lohuizen; Hiroshi Kawamoto; Masamoto Kanno
        IMMUNITY, Feb. 2008, Peer-reviewed
      • Quantification of progenitors capable of generating T cells in human cord blood
        Maiko Kato; Kyoko Masuda; Kiyokazu Kakugawa; Hiroshi Kawamoto; Hideo Mugishima; Yoshimoto Katsura
        EUROPEAN JOURNAL OF HAEMATOLOGY, Feb. 2008, Peer-reviewed
      • Recent progress on paired immunoglobulin-like receptors
        Hiromi Kubagawa; Ching-Cheng Chen; Ikuko Torii; Max D. Cooper; Kyoko Masuda; Yoshimoto Katsura; Hiroshi Kawamoto
        How the Immune System Recognizes Self and Nonself: Immunoreceptors and Their Signaling, 2008, Peer-reviewed
      • Id2 deficient mice develop myeloproliferative disorder whereas forced Id2 expression interferes with the development of BCR/ABL induced myeloid leukemia
        Ko J; N Patel; T Ikawa; H Kawamoto; O Frank; R Rivera; RA van Etten; C Murre
        PNAS, 2008, Peer-reviewed
      • Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47
        Yasutoshi Agata; Nobuyuki Tamaki; Shuji Sakamoto; Tomokatsu Ikawa; Kyoko Masuda; Hiroshi Kawamoto; Cornelis Murre
        IMMUNITY, Dec. 2007, Peer-reviewed
      • Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47
        Yasutoshi Agata; Nobuyuki Tamaki; Shuji Sakamoto; Tomokatsu Ikawa; Kyoko Masuda; Hiroshi Kawamoto; Cornelis Murre
        IMMUNITY, Dec. 2007, Peer-reviewed
      • Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells
        Atsushi Hijikata; Hiroshi Kitamura; Yayoi Kimura; Ryo Yokoyama; Yuichi Aiba; Yanyuan Bao; Shigeharu Fujita; Koji Hase; Shohei Hori; Yasuyuki Ishii; Osami Kanagawa; Hiroshi Kawamoto; Kazuya Kawano; Haruhiko Koseki; Masato Kubo; Ai Kurita-Miki; Tomohiro Kurosaki; Kyoko Masuda; Mitsumasa Nakata; Keisuke Oboki; Hiroshi Ohno; Mariko Okamoto; Yoshimichi Okayama; Jiyang O-Wang; Hirohisa Saito; Takashi Saito; Machie Sakuma; Katsuaki Sato; Kaori Sato; Ken-Ichiro Seino; Ruka Setoguchi; Yuki Tamura; Masato Tanaka; Masaru Taniguchi; Ichiro Taniuchi; Annabelle Teng; Takeshi Watanabe; Hiroshi Watarai; Sho Yamasaki; Osamu Ohara
        BIOINFORMATICS, Nov. 2007, Peer-reviewed
      • プレTCRシグナルによる胸腺細胞の増殖は、bmi-1によるp19Arfのエピゲネティックな発現制御を介して、細胞死を抑制することで維持されている(Pre-TCR-induced proliferation phase of thymocyte development is epigenetically maintained by restraining cell death through BMI-1-mediated suppression of p19Arf gene)
        宮崎 正輝; 加藤 裕子; 郭 芸; 菅野 理恵子; 糸井 マナミ; 雨貝 孝; 河本 宏; 菅野 雅元
        日本免疫学会総会・学術集会記録, Oct. 2007
      • T cell lineage determination precedes the initiation of TCR beta gene rearrangement
        Kyoko Masuda; Kiyokazu Kakugawa; Toshinori Nakayama; Nagahiro Minato; Yoshimoto Katsura; Hiroshi Kawamoto
        JOURNAL OF IMMUNOLOGY, Sep. 2007, Peer-reviewed
      • A novel muse model for invariant NKT cell study
        Hiroshi Wakao; Hiroshi Kawamoto; Sakura Sakata; Kimiko Tnoue; Atsuo Gura; Rika Wakao; Atsushi Da; Hiroyoshi Fujita
        JOURNAL OF IMMUNOLOGY, Sep. 2007, Peer-reviewed
      • T cell lineage determination precedes the initiation of TCR beta gene rearrangement
        Kyoko Masuda; Kiyokazu Kakugawa; Toshinori Nakayama; Nagahiro Minato; Yoshimoto Katsura; Hiroshi Kawamoto
        JOURNAL OF IMMUNOLOGY, Sep. 2007, Peer-reviewed
      • The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells
        Joanne G. W. Nijhof; Kristin M. Braun; Adam Giangreco; Carina van Pelt; Hiroshi Kawamoto; Richard L. Boyd; Rein Willemze; Leon H. F. Mullenders; Fiona M. Watt; Frank R. de Gruijl; Willem van Ewijk
        DEVELOPMENT, Aug. 2006, Peer-reviewed
      • E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
        T Ikawa; H Kawamoto; AW Goldrath; C Murre
        JOURNAL OF EXPERIMENTAL MEDICINE, May 2006, Peer-reviewed
      • Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection
        Makiko Motohara; Kentaro Ibuki; Ariko Miyake; Yoshinori Fukazawa; Katsuhisa Inaba; Hajime Suzuki; Kyoko Masuda; Nagahiro Minato; Hiroshi Kawamoto; Tadashi Nakasone; Mitsuo Honda; Masanori Hayami; Tomoyuki Miura
        MICROBES AND INFECTION, May 2006, Peer-reviewed
      • E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
        T Ikawa; H Kawamoto; AW Goldrath; C Murre
        JOURNAL OF EXPERIMENTAL MEDICINE, May 2006, Peer-reviewed
      • A close developmental relationship between the lymphoid and myeloid lineages
        H Kawamoto
        TRENDS IN IMMUNOLOGY, Apr. 2006, Peer-reviewed
      • Transient increase of serum granulysin in a stage IVs neuroblastoma patient during spontaneous regression: Case report
        M Nagasawa; H Kawamoto; Y Tsuji; S Mizutani
        INTERNATIONAL JOURNAL OF HEMATOLOGY, Dec. 2005, Peer-reviewed
      • Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors
        K Masuda; H Kubagawa; T Ikawa; CC Chen; K Kakugawa; M Hattori; R Kageyama; MD Cooper; N Minato; Y Katsura; H Kawamoto
        EMBO JOURNAL, Dec. 2005, Peer-reviewed
      • The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCR beta chains than fetal progenitors
        M Lu; R Tayu; T Ikawa; K Masuda; Matsumoto, I; H Mugishima; H Kawamoto; Y Katsura
        JOURNAL OF IMMUNOLOGY, Nov. 2005, Peer-reviewed
      • The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCR beta chains than fetal progenitors
        M Lu; R Tayu; T Ikawa; K Masuda; Matsumoto, I; H Mugishima; H Kawamoto; Y Katsura
        JOURNAL OF IMMUNOLOGY, Nov. 2005, Peer-reviewed
      • Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the notch pathway
        M Miyazaki; H Kawamoto; Y Kato; M Itoi; K Miyazaki; K Masuda; S Tashiro; H Ishihara; K Igarashi; T Amagai; R Kanno; M Kanno
        JOURNAL OF IMMUNOLOGY, Mar. 2005, Peer-reviewed
      • Thymic anlage is colonized by progenitors restricted to T, NK, and dendritic cell lineages
        K Masuda; M Itoi; T Amagai; N Minato; Y Katsura; H Kawamoto
        JOURNAL OF IMMUNOLOGY, Mar. 2005, Peer-reviewed
      • Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques
        H Suzuki; M Motohara; A Miyake; K Ibuki; Y Fukazawa; K Inaba; K Masuda; N Minato; H Kawamoto; M Hayami; T Miura
        MICROBIOLOGY AND IMMUNOLOGY, 2005, Peer-reviewed
      • A new clonal assay system for lymphoid and myeloid lineages.
        H. Kawamoto; Y. Katsura
        Methods in molecular medicine, 2005, Peer-reviewed
      • Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation
        Y Li; T Koshiba; A Yoshizawa; Y Yonekawa; K Masuda; A Ito; M Ueda; T Mori; H Kawamoto; Y Tanaka; S Sakaguchi; N Minato; KJ Wood; K Tanaka
        AMERICAN JOURNAL OF TRANSPLANTATION, Dec. 2004, Peer-reviewed
      • Myeloid cells
        A Kawamoto; N Minato
        INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Aug. 2004, Peer-reviewed
      • Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent
        T Ikawa; H Kawamoto; LYT Wright; C Murre
        IMMUNITY, Mar. 2004, Peer-reviewed
      • Identification of the earliest prethymic T-cell progenitors in murine fetal blood
        T Ikawa; K Masuda; M Lu; N Minato; Y Katsura; H Kawamoto
        BLOOD, Jan. 2004, Peer-reviewed
      • 胸腺内T細胞初期分化(ETPs)におけるポリコーム遺伝子mel-18の役割(その2)
        宮崎 正輝; 加藤 裕子; 河本 宏; 糸井 マナミ; 雨貝 孝; 石原 浩人; 菅野 理恵子; 菅野 雅元
        日本免疫学会総会・学術集会記録, Nov. 2003
      • 胸腺内T細胞初期分化(ETPs)におけるポリコーム遺伝子mel-18の役割(その1)
        加藤 裕子; 宮崎 正輝; 河本 宏; 糸井 マナミ; 雨貝 孝; 石原 浩人; 菅野 雅元
        日本免疫学会総会・学術集会記録, Nov. 2003
      • TAK bipotent progenitors in the thymus retain the potential to generate dendritic cells
        HQ Shen; M Lu; T Ikawa; K Masuda; K Ohmura; N Minato; Y Katsura; H Kawamoto
        JOURNAL OF IMMUNOLOGY, Oct. 2003, Peer-reviewed
      • Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors
        WTV Germeraad; H Kawamoto; M Itoi; YF Jiang; T Amagai; Y Katsura; W van Ewijk
        JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Sep. 2003, Peer-reviewed
      • Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors
        WTV Germeraad; H Kawamoto; M Itoi; YF Jiang; T Amagai; Y Katsura; W van Ewijk
        JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Sep. 2003, Peer-reviewed
      • Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
        D Ishida; K Kometani; HL Yang; K Kakugawa; K Masuda; K Iwai; M Suzuki; S Itohara; T Nakahata; H Hiai; H Kawamoto; M Hattori; N Minato
        CANCER CELL, Jul. 2003, Peer-reviewed
      • Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains
        H Kawamoto; K Ohmura; S Fujimoto; M Lu; T Ikawa; Y Katsura
        EUROPEAN JOURNAL OF IMMUNOLOGY, Mar. 2003, Peer-reviewed
      • Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains
        H Kawamoto; K Ohmura; S Fujimoto; M Lu; T Ikawa; Y Katsura
        EUROPEAN JOURNAL OF IMMUNOLOGY, Mar. 2003, Peer-reviewed
      • 胸腺内T細胞分化における低分子量G蛋白,Rap1の役割 SPA-1トランスジェニックマウスを用いた解析
        米谷 耕平; 増田 喬子; 河本 宏; 服部 雅一; 湊 長博
        日本免疫学会総会・学術集会記録, Oct. 2002
      • The common myelolymphoid progenitor: A key intermediate stage in hemopoiesis generating T and B cells
        M Lu; H Kawamoto; Y Katsube; T Ikawa; Y Katsura
        JOURNAL OF IMMUNOLOGY, Oct. 2002, Peer-reviewed
      • The common myelolymphoid progenitor: A key intermediate stage in hemopoiesis generating T and B cells
        M Lu; H Kawamoto; Y Katsube; T Ikawa; Y Katsura
        JOURNAL OF IMMUNOLOGY, Oct. 2002, Peer-reviewed
      • Prethymic and intrathymic pathway of T cell development
        H. Kawamoto; Y. Katsura
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2002, Peer-reviewed
      • The process of lineage commitment in hematopoiesis
        H. Kawamoto; Y. Katsura
        [Rinsho ketsueki] The Japanese journal of clinical hematology, 2002, Peer-reviewed
      • Expression of alpha(4)beta(7) integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells
        H Yoshida; H Kawamoto; SM Santee; H Hashi; K Honda; S Nishikawa; CF Ware; Y Katsura; S Nishikawa
        JOURNAL OF IMMUNOLOGY, Sep. 2001, Peer-reviewed
      • Expression of alpha(4)beta(7) integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells
        H Yoshida; H Kawamoto; SM Santee; H Hashi; K Honda; S Nishikawa; CF Ware; Y Katsura; S Nishikawa
        JOURNAL OF IMMUNOLOGY, Sep. 2001, Peer-reviewed
      • Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage
        M Itoi; H Kawamoto; Y Katsura; T Amagai
        INTERNATIONAL IMMUNOLOGY, Sep. 2001, Peer-reviewed
      • The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor
        T Egawa; K Kawabata; H Kawamoto; K Amada; R Okamoto; N Fujii; T Kishimoto; Y Katsura; T Nagasawa
        IMMUNITY, Aug. 2001, Peer-reviewed
      • Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2
        T Ikawa; S Fujimoto; H Kawamoto; Y Katsura; Y Yokota
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2001, Peer-reviewed
      • Immature multipotent hemopoietic progenitors lacking long-term bone marrow-reconstituting activity in the aorta-gonad-mesonephros region of murine bay 10 fetuses
        K Ohmura; H Kawamoto; M Lu; T Ikawa; S Ozaki; K Nakao; Y Katsura
        JOURNAL OF IMMUNOLOGY, Mar. 2001, Peer-reviewed
      • Immature multipotent hemopoietic progenitors lacking long-term bone marrow-reconstituting activity in the aorta-gonad-mesonephros region of murine bay 10 fetuses
        K Ohmura; H Kawamoto; M Lu; T Ikawa; S Ozaki; K Nakao; Y Katsura
        JOURNAL OF IMMUNOLOGY, Mar. 2001, Peer-reviewed
      • Myeloid cells. Int. J. Biochem. Cell Biol. 36:1374-1379,2004. 7. Katsura, Y. and Kawamoto, H. Stepwise lineage restriction of progenitors in lympho-myelopoiesis. Intern. Rev
        Kawamoto, H; Minato, N
        Immunol, 2001, Peer-reviewed
      • Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity
        C Shimizu; H Kawamoto; M Yamashita; M Kimura; E Kondou; Y Kaneko; S Okada; T Tokuhisa; M Yokoyama; M Taniguchi; Y Katsura; T Nakayama
        INTERNATIONAL IMMUNOLOGY, Jan. 2001, Peer-reviewed
      • Stepwise lineage restriction of progenitors in lympho-myelopoiesis
        Y. Katsura; H. Kawamoto
        International Reviews of Immunology, 2001, Peer-reviewed
      • Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity
        C Shimizu; H Kawamoto; M Yamashita; M Kimura; E Kondou; Y Kaneko; S Okada; T Tokuhisa; M Yokoyama; M Taniguchi; Y Katsura; T Nakayama
        INTERNATIONAL IMMUNOLOGY, Jan. 2001, Peer-reviewed
      • Progenitors in the subpopulation of CD44(+)CD25(-)CD4(-)CD8(-) thymocytes expressing lck proximal promoter activity are restricted to T cell lineage
        C Shimizu; H Kawamoto; M Taniguchi; Y Katsura; T Nakayama
        FASEB JOURNAL, Apr. 2000, Peer-reviewed
      • Loss of B and dendritic cell progenitor potential in the lck proximal promoter-expressing CD44(+)CD25(-) CD4(-)CD8(-)thymocytes.
        C Shimizu; H Kawamoto; M Taniguchi; Y Katsura; T Nakayama
        FASEB JOURNAL, Apr. 2000, Peer-reviewed
      • T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver
        H Kawamoto; T Ikawa; K Ohmura; S Fujimoto; Y Katsura
        IMMUNITY, Apr. 2000, Peer-reviewed
      • Developing thymocytes organize thymic microenvironments
        W van Ewijk; H Kawamoto; WTV Germeraad; Y Katsura
        LYMPHOID ORGANOGENESIS, 2000, Peer-reviewed
      • Commitment of common T/natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay
        T Ikawa; H Kawamoto; S Fujimoto; Y Katsura
        JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 1999, Peer-reviewed
      • Commitment of common T/natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay
        T Ikawa; H Kawamoto; S Fujimoto; Y Katsura
        JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 1999, Peer-reviewed
      • Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse
        K Ohmura; H Kawamoto; S Fujimoto; S Ozaki; K Nakao; Y Katsura
        JOURNAL OF IMMUNOLOGY, Nov. 1999, Peer-reviewed
      • Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse
        K Ohmura; H Kawamoto; S Fujimoto; S Ozaki; K Nakao; Y Katsura
        JOURNAL OF IMMUNOLOGY, Nov. 1999, Peer-reviewed
      • Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver
        H Kawamoto; K Ohmura; S Fujimoto; Y Katsura
        JOURNAL OF IMMUNOLOGY, Mar. 1999, Peer-reviewed
      • Thymic microenvironments, 3-D versus 2-D?
        W van Ewijk; BP Wang; G Hollander; H Kawamoto; E Spanopoulou; M Itoi; T Amagai; YF Jiang; WTV Germeraad; WF Chen; Y Katsura
        SEMINARS IN IMMUNOLOGY, Feb. 1999, Peer-reviewed
      • Cutting edge: Presence of progenitors restricted to T, B, or myeloid lineage, but absence of multipotent stem cells, in the murine fetal thymus
        H Kawamoto; K Ohmura; Y Katsura
        JOURNAL OF IMMUNOLOGY, Oct. 1998, Peer-reviewed
      • In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos
        S Nishikawa; S Nishikawa; H Kawamoto; H Yoshida; M Kizumoto; H Kataoka; Y Katsura
        IMMUNITY, Jun. 1998, Peer-reviewed
      • Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver
        H Kawamoto; K Ohmura; Y Katsura
        INTERNATIONAL IMMUNOLOGY, Jul. 1997, Peer-reviewed
      • Hemopoietic progenitors in the murine fetal liver capable of rapidly generating T cells
        H Kawamoto; K Ohmura; N Hattori; Y Katsura
        JOURNAL OF IMMUNOLOGY, Apr. 1997, Peer-reviewed
      • Hemopoietic progenitors in the murine fetal liver capable of rapidly generating T cells
        H Kawamoto; K Ohmura; N Hattori; Y Katsura
        JOURNAL OF IMMUNOLOGY, Apr. 1997, Peer-reviewed
      • Isolation of the most immature population of murine fetal thymocytes that includes progenitors capable of generating T, B, and myeloid cells
        N Hattori; H Kawamoto; Y Katsura
        JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 1996, Peer-reviewed
      • Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus
        N Hattori; H Kawamoto; S Fujimoto; K Kuno; Y Katsura
        JOURNAL OF EXPERIMENTAL MEDICINE, Sep. 1996, Peer-reviewed
      • Requirement of cell interactions through adhesion molecules in the early phase of T cell development
        K Wada; T Kina; H Kawamoto; M Kondo; Y Katsura
        CELLULAR IMMUNOLOGY, May 1996, Peer-reviewed
      • LARGE MOLECULE FRACTION OF PLASMA SEPARATED WITH POLYETHYLENE-GLYCOL IN TREATMENT OF CHRONIC RELAPSING THROMBOTIC THROMBOCYTOPENIC PURPURA
        M FUJITA; K ITO; T KOYAMA; K SHINO; M NORIOKA; S KASHII; H KAWAMOTO; S MONDEN; E KAKISHITA; M OKUMA
        AMERICAN JOURNAL OF HEMATOLOGY, Jun. 1995, Peer-reviewed
      • CHARACTERIZATION OF ADENOSINE-DEAMINASE (ADA)-NEGATIVE B-LYMPHOBLASTOID CELLS COCULTURED WITH ADA-POSITIVE FIBROBLASTS
        M FUJITA; K ITO; H KAWAMOTO; S KASHII; M NORIOKA; S MONDEN; M OKUMA
        EUROPEAN JOURNAL OF HAEMATOLOGY, Apr. 1993, Peer-reviewed
      • A POINT MUTATION IN THE 5' SPLICE REGION OF INTRON-7 CAUSES A DELETION OF EXON-7 IN ADENOSINE-DEAMINASE MESSENGER-RNA
        H KAWAMOTO; K ITO; S KASHII; S MONDEN; M FUJITA; M NORIOKA; Y SASAI; M OKUMA
        JOURNAL OF CELLULAR BIOCHEMISTRY, Mar. 1993, Peer-reviewed
      • ADENOSINE-DEAMINASE DEFICIENCY DUE TO HETEROZYGOUS ABNORMALITY CONSISTING OF A DELETION OF EXON-7 AND THE ABSENCE OF ENZYME MESSENGER-RNA
        S KASHII; K ITO; S MONDEN; Y SASAI; K TSUCHIDA; M FUJITA; H KAWAMOTO; M NORIOKA; M OKUMA
        JOURNAL OF CELLULAR BIOCHEMISTRY, Sep. 1991, Peer-reviewed

      Misc.

      • T前駆細胞の同定 (免疫系の分子発生生物学)
        桂 義元; 河本 宏
        免疫, Aug. 1998
      • B細胞系列への分化決定と転写因子 (特集1 B細胞の分化とその決定要因)
        増田 喬子; 伊川 友活; 河本 宏
        臨床免疫・アレルギー科, Dec. 2006
      • B細胞系列への決定とE2A (免疫系の形成)
        伊川 友活; Murre Cornelis; 河本 宏
        免疫, 2005
      • αβT細胞とγδT細胞の系列分岐要因 (特集1 T細胞の分化をめぐって)
        角川 清和; 河本 宏
        臨床免疫・アレルギー科, Nov. 2006
      • 動物界における免疫系の進化(4)造血プロセスに現れるT,Bリンパ球進化の足跡
        桂 義元; 河本 宏
        医学のあゆみ, 13 Oct. 2001
      • An essential developmental checkpoint for production of the T cell lineage
        伊川 友活; 河本 宏
        医学のあゆみ, 26 Feb. 2011
      • Regeneration of human tumor antigen-specific cytotoxic T lymphocytes using the iPS cell technology
        増田 喬子; 河本 宏
        医学のあゆみ, 16 Apr. 2016
      • Clinical application of the iPS cell technology to novel immune cell therapy against cancer
        増田 喬子; 河本 宏
        バイオサイエンスとインダストリー, 2014
      • Overview: innate immunity and adaptive immunity
        河本宏
        臨床検査, 2022
      • Cancer immunotherapy using T cells regenerated from iPS cells-Development of universal ”off-the-shelf” T cell medicine
        河本宏; 増田喬子; 永野誠治
        医学のあゆみ, 2022
      • 【COVID-19】総論 SARS-CoV-2に対する免疫応答
        河本 宏
        小児内科, Jan. 2022
      • Regeneration of antigen-specific T cells by using induced pluripotent stem cell (iPSC) technology
        Hiroshi Kawamoto; Kyoko Masuda; Seiji Nagano
        International Immunology, 18 Oct. 2021
      • Evolving Paradigm for Blood Cell Differentiation 血液細胞の起源とミエロイド細胞
        長畑 洋佑; 増田 喬子; 河本 宏
        臨床血液, May 2021
      • Possible NK cell mediated immune responses against iPS-derived regenerated cells in allogenic transplantation
        増田 喬子; 河本 宏
        医学のあゆみ, 20 Feb. 2021
      • Possible immune response against iPS-derived regenerated cells in allogenic transplantation
        河本 宏; 増田 喬子
        再生医療, Feb. 2021
      • Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings.
        Kyoko Masuda; Hiroshi Kawamoto
        Inflammation and regeneration, 06 Jan. 2021
      • Development of universal “off-the-shelf” T cells for cancer immunotherapy.
        河本宏; 増田喬子; 永野誠治; 永野誠治
        月刊腫瘍内科, 2021
      • 免疫応答の基本的な仕組み (特集 感染症から子どもを守るために : 新型コロナウイルス感染症からの学びとワクチンの最新情報) -- (感染症と免疫・ワクチン)
        河本 宏
        小児科臨床 = Japanese journal of pediatrics, Dec. 2020
      • Current status and issues in immunology : insight from the historical viewpoint
        河本 宏
        医学のあゆみ, 14 Nov. 2020
      • 【癌と再生医療】多能性幹細胞から再生キラーT細胞を量産 固形がんへの応用
        嘉島 相輝; 増田 喬子; 河本 宏
        癌と化学療法, Oct. 2020
      • Framework of immune response : cooperation of innate immunity and adaptive immunity
        河本 宏
        医学のあゆみ, 18 Jul. 2020
      • Development of cancer immunotherapy using CTLs regenerated from iPS cells : To target solid tumor expressing WT1 antigen
        嘉島 相輝; 増田 喬子; 河本 宏
        医学のあゆみ, 02 May 2020
      • Development of off-the-shelf T cells for cancer immunotherapy
        河本宏; 増田喬子
        実験医学, 2020
      • History of cell therapy
        河本宏
        実験医学, 2020
      • iPS細胞技術を用いたがん抗原特異的CTLの量産 他家移植用再生T細胞製剤の開発
        河本 宏; 永野 誠治
        癌と化学療法, Nov. 2019
      • がんと再生医療 多能性幹細胞からキラーT細胞を再生 他家移植用即納型T細胞製剤の開発
        河本 宏
        日本癌治療学会学術集会抄録集, Oct. 2019
      • 【がん免疫療法の個別化を支える 新・腫瘍免疫学】第I部 腫瘍免疫応答の基本とその制御メカニズム (第2章)腫瘍免疫応答の制御法 多能性幹細胞由来免疫細胞を用いたがん免疫療法
        河本 宏; 増田 喬子
        実験医学, Sep. 2019
      • 免疫療法の効果と耐性 多能幹細胞からCTLを再生 即納型T細胞製剤の開発(Cancer immunotherapy sensitivity and resistance Generation of CTLs from pluripotent stem cells: toward the development of "off-the-shelf T cells")
        河本 宏
        日本癌学会総会記事, Sep. 2019
      • 再生医療とがん免疫療法の現状と問題点 再生T細胞を用いたがんの免疫細胞療法の開発
        河本 宏
        耳鼻咽喉科免疫アレルギー, Jun. 2019
      • 【再生医療up to date】【レギュレートリーサイエンス】iPS細胞由来再生細胞を他家移植で用いたときに起こりうる免疫反応
        増田 喬子; 河本 宏
        腎と透析, Mar. 2019
      • よくわかる免疫学:獲得免疫編
        河本宏
        日本免疫不全・自己炎症学会総会・学術集会プログラム・抄録集, 2019
      • iPS細胞技術を用いたがん抗原特異的CTLの量産―即納型T細胞製剤の開発に向けて―
        河本宏
        日本再生医療学会総会(Web), 2019
      • 2018年度ノーベル生理学・医学賞解説 免疫チェックポイント阻害剤の作用機序と開発過程
        河本 宏
        遺伝 : 生物の科学, Jan. 2019
      • Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow
        Takuya Uehata; Daisuke Ori; Masaki Miyazaki; Hiroshi Kawamoto; Osamu Takeuchi
        日本免疫学会学術集会, Dec. 2018
      • iPS細胞技術を用いたがん抗原特異的キラーT細胞の再生 他家移植の系で使える即納T細胞製剤の開発
        河本 宏
        Cytometry Research, May 2018
      • Cloning and expansion of antigen-specific T cells using iPS cell technology: development of "off-the-shelf" T cells for the use in allogeneic transfusion settings.
        Hiroshi Kawamoto; Kyoko Masuda; Seiji Nagano; Takuya Maeda
        International journal of hematology, Mar. 2018, Peer-reviewed
      • iPS細胞技術を駆使したがん,感染症のあらたな制御 再生したキラーT細胞を用いたがんの免疫細胞療法―他家移植用の即納T細胞製剤の開発
        河本宏
        医学のあゆみ, 23 Dec. 2017
      • iPS細胞技術を用いたがん抗原特異的キラーT細胞の再生―ネオアンチゲンを標的とした個別化医療への応用―
        河本宏
        Personalized Medicine Universe. Japanese Edition, Oct. 2017
      • 造血幹細胞からT前駆細胞へ至る系列決定過程と決定状態の維持機構
        河本宏; 増田喬子; 伊川友活
        日本生化学会大会(Web), 2017
      • 再生医療の現状と問題点―再生T細胞を用いたがんの免疫細胞療法の開発―
        河本宏
        愛知学院大学歯学会学術大会抄録, 2017
      • NK cell-mediated immune response against tissue/cells regenerated from iPS cells
        河本宏; 増田喬子
        移植(Web), 2017
      • 白血病の基礎研究と臨床研究の動向 造血幹細胞と白血病幹細胞研究の動向 血液細胞の分化経路
        河本宏; 増田喬子
        日本臨床, 20 Dec. 2016
      • Regeneration of Tumor Antigen Specific CTLs Utilizing iPSC Technology for Off-the-Shelf Immunotherapy
        Takuya Maeda; Seiji Nagano; Kyoko Masuda; Toshio Kitawaki; Keisuke Kataoka; Seishi Ogawa; Norimitsu Kadowaki; Akifumi Kondo Takaori; Hiroshi Kawamoto
        BLOOD, Dec. 2016
      • 今日の免疫学 : 基本的な仕組みから新しい考え方まで (特集 免疫研究最前線)
        河本 宏
        遺伝 : 生物の科学, Nov. 2016
      • 再生医療の現状と免疫学的な問題
        河本宏
        日本臨床免疫学会会誌, 20 Aug. 2016
      • Regeneration of tumor antigen-specific CTLs utilizing iPS technology
        前田 卓也; 増田 喬子; 河本 宏
        臨床血液, Aug. 2016
      • Transcriptional networks that establish B cell identity
        T. Ikawa; T. Miyai; H. Kawamoto
        EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016
      • がん免疫療法 腫瘍免疫学の最新知見から治療法のアップデートまで 第II部 がん免疫療法の開発と臨床試験 第5章 開発が進む多彩ながん免疫療法 6.iPS細胞技術により再生したT細胞を用いたがんの免疫細胞療法の開発
        河本宏; 増田喬子; 前田卓也; 前田卓也
        実験医学, 01 Aug. 2016
      • REGENERATION OF WT1 SPECIFIC CTLS UTILIZING IPSC TECHNOLOGY
        T. Maeda; S. Nagano; K. Masuda; T. Kitawaki; A. Takaori-Kondo; H. Kawamoto
        HAEMATOLOGICA, Jun. 2016
      • iPS細胞技術を用いたがん抗原特異的T細胞のクローニングと再生 (特集 膵島再生 : 膵臓・膵島移植からiPS細胞を用いた膵再生と他の臓器の再生医療まで)
        河本 宏; 増田 喬子
        糖尿病, Jun. 2016
      • Regeneration of tumor antigen specific CTLs utilizing iPSC technology
        Takuya Maeda; Seiji Nagano; Hiroshi Ichise; Kyoko Masuda; Toshio Kitawaki; Akifumi Kondo-Takaori; Hiroshi Kawamoto
        CANCER IMMUNOLOGY RESEARCH, Jan. 2016
      • ビギナーズセミナー10 再生医療の現状と免疫学的な問題
        河本 宏
        日本臨床免疫学会会誌, 2016
      • THE COMMENTARY 免疫学の視点で再生医療を眺めてみる
        河本 宏; 一瀬 大志; 増田 喬子
        再生医療 : 日本再生医療学会雑誌, Nov. 2015
      • Basic research in tumor immunology : recent progress : cloning and regeneration of antigen specific T cells using iPS cell technology
        河本 宏
        腫瘍内科 = Clinical oncology, Mar. 2015
      • EBF Deficient Hematopoietic Progenitor Cells Potentialy Differentiated into Immature B Cell: EBF1 Dispensable for B Cell Linage Commitment from Pro-B to Pre-B Stage
        Bidisha Chanda; Tomokatsu Ikawa; Kazuki Okuyama; Katsuto Hozumi; Kiyoshi Ando; Arinobu Tojo; Hiroshi Kawamoto; Ai Kotani
        BLOOD, Dec. 2014
      • EBF Deficient Hematopoietic Progenitor Cells Potentialy Differentiated into Immature B Cell: EBF1 Dispensable for B Cell Linage Commitment from Pro-B to Pre-B Stage
        Bidisha Chanda; Tomokatsu Ikawa; Kazuki Okuyama; Katsuto Hozumi; Kiyoshi Ando; Arinobu Tojo; Hiroshi Kawamoto; Ai Kotani
        BLOOD, Dec. 2014
      • A novel method for the cloning of antigen specific T cells and its potential clinical application
        河本 宏; 増田 喬子
        臨床免疫・アレルギー科, Mar. 2014
      • A revised scheme of developmental tree in hematopoiesis: insight into the origin of mixed phenotype leukemia
        KAWAMOTO Hiroshi
        Rinsho Ketsueki, 2014
      • シンポジウム2-5 iPS細胞技術を用いた抗原特異的T細胞のクローニングとがんの免疫細胞療法への応用
        河本 宏
        日本臨床免疫学会会誌, 2014
      • 体を守る巧みなしくみ 「免疫力」ってどんなチカラ? (特集 新年をいきいきと過ごすために 免疫力アップ)
        河本 宏
        栄養と料理, Jan. 2014
      • Application of the iPSC technology to immune cell therapy against cancer
        河本 宏
        腫瘍内科, Oct. 2013
      • iPS細胞技術を用いたがん特異的キラーT細胞の再生 : がんの免疫細胞療法の革新的戦略
        河本 宏
        科学, Jun. 2013
      • Lineage Commitment Process of Progenitors during Hematopoiesis : Revision of a Classical Myeloid/Lymphoid Dichotomy Concept
        KAWAMOTO Hiroshi; KATSURA Yoshimoto
        KAGAKU TO SEIBUTSU, 01 Aug. 2012
      • T-Cell Development Failure At beta-Selection Checkpoint and TCR alpha/delta Locus Break Formation Associated with Chromosome 14 Translocation in Ataxia-Telangiectagia Mutated Deficient Mice
        Takeshi Isoda; Masatoshi Takagi; Jinhua Piao; Shun Nakagama; Masaki Sato; Kyoko Masuda; Tomokatsu Ikawa; Miyuki Azuma; Tomohiro Morio; Hiroshi Kawamoto; Shuki Mizutani
        BLOOD, Nov. 2011
      • Individual Hematopoietic Stem Cells in Human Bone Marrow Stably Give Rise to Limited Cell Lineages
        Takamasa Katagiri; Hiroshi Kawamoto; Takashi Nakakuki; Mariko Okada; Shigeki Ohtake; Shinji Nakao
        BLOOD, Nov. 2011
      • 造血・免疫系形成 ヒトiPS細胞からのヒトCD34+造血前駆細胞の誘導(Development of human CD34+ hematopoietic progenitors from human iPS cells)
        富澤 麻利子; 山田 大輔; 斉藤 頼子; 土方 敦司; 渡辺 貴志; 名島 悠峰; 増田 喬子; 大越 桃子; 河本 宏; 小原 収; 古関 明彦; 石川 文彦
        日本免疫学会総会・学術集会記録, Nov. 2011
      • 知っておかなければならない アレルギー疾患の基礎的知識(1・新連載)白血球分化経路の新しいパラダイム
        河本 宏; 桂 義元
        アレルギ-・免疫, Mar. 2010
      • Ectopically expressed PIR‐B on T cells constitutively binds to MHC class I cis and attenuates T helper type 1 responses.
        IMADA Michiyo; MASUDA Kyoko; SATOH Rumi; ITO Yumi; GOTOH Yoshiyuki; MATSUOKA Takayuki; ENDO Shota; NAKAMURA Akira; KAWAMOTO Hiroshi; TAKAI Toshiyuki
        日本免疫学会総会・学術集会記録, 10 Nov. 2009
      • Response to Comment on "Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreER(T2)"
        Motoko Yanagita; Atsuko Higashi; Tomokatsu Ikawa; Masamichi Muramatsu; Aris N. Economides; Hiroshi Kawamoto
        JOURNAL OF IMMUNOLOGY, Sep. 2009
      • "リンパ球系列"という既成概念からの解放--血液細胞分化研究におけるパラダイムシフト
        河本 宏; 桂 義元
        科学, Jun. 2009
      • Revised scheme for lymphoid and myeloid cell development
        河本 宏; 和田 はるか
        血液・腫瘍科, Jan. 2009
      • Mining Column 血液細胞の新しい分化経路図
        河本 宏; 和田 はるか; 桂 義元
        メディカルバイオ, Sep. 2008
      • T前駆細胞の発生 (特集 胸腺の発生とT細胞の分化--教科書に出ていない免疫構造の新図式)
        河本 宏; 桂 義元
        メディカルバイオ, Jan. 2008
      • 胸腺の構築における胸腺細胞と胸腺上皮細胞間の相互作用 (免疫系の形成)
        河本 宏; 増田 喬子; van Ewijk Willem
        免疫, 2006
      • 強毒・弱毒SHIV の感染初期における胸腺組織及び胸腺内T 前駆細胞の解析
        元原麻貴子; 伊吹謙太郎; 三宅在子; 深澤嘉伯; 稲葉一寿; 鈴木元; 増田恭子; 河本宏; 仲宗根正; 本多三男; 速水正憲; 三浦智行
        第19回日本エイズ学会、2005 年12 月1 日~3 日、熊本, 2005, Peer-reviewed
      • Impaired T cell differentiation in the thymus at the early stages of acute pathogenic SHIV infection in monkeys in comparison to low pathogenic SHIV infection.
        Motohara M; Ibuki K; Miyake A; Fukazawa Y; Inaba K; Suzuki H; Masuda K; Minato N; Kawamoto H; Nakasone T; Honda M; Hayami M; Miura T
        23rd annual Symposium on Nonhuman Primate Models for AIDS, September 21-24, 2005, Oregon, 2005, Peer-reviewed
      • リンパ球再生による免疫細胞療法の開発
        河本 宏
        日本輸血学会雑誌, 25 Sep. 2004
      • 基礎 樹状細胞サブセットの起源 (特集 樹状細胞--基礎と臨床)
        河本 宏; 桂 義元
        現代医療, Aug. 2003
      • T細胞の発生・分化のゲノム機能 (特集 原発性免疫不全症とゲノム) -- (第1部 ゲノム機能からみたリンパ球の発生と分化)
        河本 宏; 桂 義元
        ゲノム医学, Jun. 2003
      • 胎仔胸腺に移行するT前駆細胞 (免疫研究の最前線--高次複雑系免疫システムの包括的理解をめざして) -- (リンパ球分化の分子メカニズム)
        河本 宏; 桂 義元
        蛋白質核酸酵素, Dec. 2002
      • 造血における系列コミットメントのプロセス
        河本 宏; 桂 義元
        臨床血液, 30 Apr. 2002
      • 胸腺中のT/NK/樹状細胞系列に共通の前駆細胞 (免疫細胞の発生・分化)
        河本 宏; 伊川 友活; 桂 義元
        免疫, 2002
      • リンパ球亜群への分化と関与要因--系列決定は環境によって誘導されるか
        河本 宏; 桂 義元
        臨床免疫, Aug. 2001
      • 造血幹細胞からのリンパ球分化 (9月第5土曜特集 造血の再生医学と細胞療法) -- (造血幹細胞)
        河本 宏; 桂 義元
        医学のあゆみ, 30 Sep. 2000
      • 樹状細胞サブセットの分化と起源 (特集 樹状細胞--免疫応答の新たな主役)
        河本 宏; 桂 義元
        細胞工学, Sep. 2000
      • T細胞系列を含む造血における分化決定に関する考察
        河本 宏; 桂 義元
        臨床免疫, Jul. 2000
      • 血液・リンパ系を対象とする再生医療 (特集 21世紀における再生医療の役割(Part2))
        河本 宏; 桂 義元
        バイオインダストリ-, Feb. 2000

      Presentations

      • iPS 細胞を材料とした即納型汎用性T 細胞製剤の開発-がんおよびウイルス感染症への応用-
        河本宏
        第42回阿蘇シンポジウム, 23 Jul. 2022
      • 細胞医薬の時代の到来:iPS細胞を材料とした汎用性即納型T細胞製剤によるがん免疫療法の開発
        河本 宏
        第26回日本がん免疫学会総会, 21 Jul. 2022
      • iPS細胞由来キラーT細胞を用いたCOVID-19治療法の開発
        河本 宏
        第43回日本炎症・再生医学会, 06 Jul. 2022
      • アレルギーが起こる仕組み:そもそも何のためにある反応?自己免疫疾患との違いは?
        河本 宏
        第38回日本小児臨床アレルギー学会, 03 Jul. 2022
      • T細胞を知る、創る
        河本 宏
        2022 (令和4年) 金沢大学十全医学会学術集会, 14 Jun. 2022
      • 腫瘍免疫のいまと今後の展望~iPS細胞技術を用いたがん抗原特異的キラーT細胞の作製~
        河本 宏
        第19回泌尿器科再建再生研究会, 04 Jun. 2022
      • iPS 細胞を材料とした即納型汎用性T 細胞製剤の開発-がんおよびウイルス感染症への応用-
        河本 宏
        大阪大学先導的学際研究機構 生命医科学融合フロンティア研究部門シンポジウム, 28 Mar. 2022
      • 他家再生細胞を用いた時に起こりうる免疫反応とその制御法の開発
        河本 宏
        第21回日本再生医療学会総会, 19 Mar. 2022
      • TCRカセット法の開発:iPS細胞に安全かつ簡便にTCR遺伝子を導入
        河本 宏
        第21回日本再生医療学会総会, 18 Mar. 2022
      • iPS細胞由来キラーT細胞を用いたCOVID-19治療法の開発
        河本 宏
        第21回日本再生医療学会総会, 17 Mar. 2022
      • 即納型T細胞製剤によるがん免疫療法の開発
        河本 宏
        第1回京都大学ウイルス・再生医科学研究所附属ヒトE S細胞研究センター シンポジウム, 09 Mar. 2022
      • iPS細胞を材料とした即納型汎用性T細胞製剤の開発-がんおよびウイルス感染症への応用-
        河本宏
        第34回バイオセラピィ学会学術集会総会, 17 Dec. 2021
      • iPS細胞から作製したT細胞製剤-がんおよびウイルス感染症への応用-
        河本宏
        第32回日本消化器癌発生学会総会, 27 Nov. 2021
      • iPS細胞を材料とした即納型汎用性T細胞製剤の開発-がん免疫療法およびウイルス感染症治療への応用-
        河本宏
        第39回日本ヒト細胞学会学術集会, 30 Oct. 2021
      • 免疫学の基礎と最前線:自己免疫疾患-がん免疫療法から新型コロナ感染症まで-
        河本宏
        第30回日本小児リウマチ学会学術集会, 16 Oct. 2021
      • iPS細胞を材料とした即納型汎用性T細胞製剤の開発-急性骨髄性白血病を対象とした臨床試験に向けて-
        河本宏
        第29回日本組織適合性学会大会, 03 Sep. 2021
      • iPS細胞を材料とした即納型汎用性T細胞製剤の開発-急性骨髄性白血病を対象とした臨床試験に向けて-
        河本宏
        第42回日本炎症・再生医学会, 08 Jul. 2021
      • iPS細胞を材料とした即納型汎用性T細胞製剤の開発-急性骨髄性白血病を対象とした臨床試験に向けて
        河本 宏
        第13回日本血液疾患免疫療法学会学術集会, 19 Jun. 2021
      • iPS細胞を材料とした即納型汎用性T細胞製剤の開発-急性骨髄性白血病を対象とした臨床試験に向けて-
        河本 宏
        第30回日本癌病態治療研究会, 11 Jun. 2021
      • iPS細胞を材料とした汎用性即納型T細胞製剤による白血病治療法の開発
        河本宏
        第18回日本免疫治療学会学術集会, 23 May 2021
      • iPS細胞を材料とした即納型汎用性T細胞製剤の開発-臨床試験に向けた開発と次世代型を目指した改良-
        河本宏
        第85回インターフェロン・サイトカイン学会学術集会, 21 May 2021
      • iPS細胞に安全かつ簡便にTCR遺伝子を導入する方法:TCRカセット法の開発
        河本 宏
        第20回日本再生医療学会総会, 13 Mar. 2021
      • iPS細胞を材料とした即納型汎用性T細胞製剤の開発-急性骨髄性白血病を対象とした臨床試験に向けて
        河本 宏
        第20回日本再生医療学会総会, 11 Mar. 2021
      • 他家再生細胞を用いた時に起こりうる免疫反応とその頻度の予測
        河本 宏
        第20回日本再生医療学会総会, 11 Mar. 2021
      • 即納型再生T細胞製剤を用いたがんおよびウイルス感染症の治療法の開発
        河本 宏
        第100回山口県臨床細胞学会学術集会, 07 Mar. 2021
      • Generation of cytotoxic T lymphocytes from iPS cells: Development of “off-the-shelf T cells” for cell therapy targeting cancer and viral infection.
        Hiroshi Kawamoto
        Japan Healthcare Update Conference, 04 Mar. 2021
      • 即納型再⽣キラーT 細胞を⽤いたがん免疫療法の開発
        河本 宏
        第2回東京理科大学総合研究院合成生物学研究部門シンポジウム, 19 Feb. 2021
      • 多能性幹細胞を材料とした汎用性即納型T細胞製剤の開発
        河本 宏
        第48回日本臨床免疫学会総会, 20 Oct. 2020
      • Regeneration of T cells using the iPS cell technology: Development of “off-the-shelf T cells” for cancer immunotherapy.
        Hiroshi Kawamoto
        47th IMSUT Founding Commemorative Symposium “Neo-Immunology on infection, allergy and cancer”, 27 Nov. 2020
      • Conversion of T, B, erythroid and megakaryocyte progenitors to myeloid cells by inactivation of polycomb complex
        河本 宏
        第82回日本血液学会学術集会, 10 Oct. 2020
      • TCR遺伝子導入iPS細胞からCTLを再生するための新規の方法:TCRカセット法の開発
        河本 宏
        第12回日本血液疾患免疫療法学会学術集会, 12 Sep. 2020
      • iPS細胞技術を用いたがん抗原特異的CTLの量産-即効型T細胞製剤の開発-
        河本 宏
        第17回日本免疫治療学会学術集会, 22 Feb. 2020
      • よくわかる免疫学:自然免疫編
        河本 宏
        第3回日本免疫不全・自己炎症学会, 15 Feb. 2020
      • 腫瘍免疫の基礎と臨床-即納型T細胞製剤の開発-
        河本 宏
        第24回造血器腫瘍研究会, 01 Feb. 2020
      • Generation of CTLs from iPSCs Transduced with TCR Genes: Toward the Development of “Off- the-Shelf T cells”
        Hiroshi Kawamoto
        Cell & Gene Therapy Asia 2019, 12 Nov. 2019
      • iPS細胞技術を用いたがん抗原特異的T細胞の量産-即納型T細胞製剤の開発-
        河本 宏
        第57回日本癌治療学会学術集会, 26 Oct. 2019
      • iPS細胞技術を用いた抗原特異的CTLの量産
        河本 宏
        第11回日本血液疾患免疫療法学会学術集会, 05 Oct. 2019
      • Generation of CTLs from iPSCs transduced with TCR genes: toward the development of “off- the-shelf T cells”
        河本 宏
        第78回日本癌学会学術総会, 28 Sep. 2019
      • iPS細胞技術を用いた抗原特異的T細胞の再生-「即納型T細胞製剤」の開発-
        河本 宏
        第40回阿蘇シンポジウム, 26 Jul. 2019
      • CTLs regenerated from iPSCs transduced with clinically used TCR genes exert therapeutic effect in xenograft models.
        Hiroshi Kawamoto
        ThymeE: T cell and thymus biology, 23 May 2019, Invited
      • iPS細胞技術を用いたがん抗原特異的キラーT細胞の量産-即納型T細胞製剤の開発に向けて-
        河本 宏
        第30回日本医学会総会, 28 Apr. 2019
      • iPS細胞技術を用いたがん抗原特異的CTLの量産 —即納型T細胞製剤の開発に向けて—
        河本 宏
        第18回日本再生医療学会総会, 21 Mar. 2019
      • Regeneration of antigen-specific T cells using the iPSC technology.
        Hiroshi Kawamoto
        Stem Cell & Immune Cell Therapy, 26 Feb. 2019
      • 再生医療とがん免疫療法の現状と問題点 -再生T細胞を用いたがんの免疫細胞療法の開発-
        河本 宏
        第37回耳鼻咽喉科免疫アレルギー学会, 07 Feb. 2019
      • よくわかる免疫学:獲得免疫編
        河本 宏
        第2回日本免疫不全・自己炎症学会, 02 Feb. 2019
      • 腫瘍免疫学の基礎と臨床 -即納型T細胞製剤の開発-
        河本 宏
        第4回日本骨免疫学会ウィンターセミナー, 24 Jan. 2019
      • iPS細胞技術を用いたがん抗原特異的CTLの量産 —即納型T細胞製剤の開発に向けて—
        河本 宏
        第46回日本臨床免疫学会総会, 08 Nov. 2018
      • Regeneration of antigen-specific T cells using the iPS cell technology.
        Hiroshi Kawamoto
        The 1st International Symposium on NEO-SELF, 10 Jul. 2018
      • iPS細胞技術を用いたがん抗原特異的キラーT細胞の再生 ー他家移植の系で使えるT細胞製剤の開発ー
        Hiroshi Kawamoto
        第28回日本サイトメトリー学会学術集会,, 26 May 2018, Invited
      • Generation of CTLs from iPSCs transduced with TCR genes: toward the development of “off-the-shelf T cells
        Hiroshi Kawamoto
        Thym Oz, 23 Mar. 2018
      • Generation of CTLs from iPSCs transduced with TCR genes: toward the development of “off-the-shelf T cells
        Hiroshi Kawamoto
        Eradicate Cancer 2018, 17 Mar. 2018, Invited
      • T細胞の発生と再生 -T細胞分化過程の解明と再生T細胞を用いた免疫細胞療法の開発-
        Hiroshi Kawamoto
        第3回日本骨免疫学会ウィンターセミナー, 26 Jan. 2018, Invited
      • 転写とエピゲノム制御による免疫細胞の分化制御と疾患
        Hiroshi Kawamoto
        ConBio2017 2017年度生命科学系学会合同年次大会, 07 Dec. 2017, Invited
      • 再生医療の現状と問題点-再生T細胞を用いたがんの免疫細胞療法の開発-
        Hiroshi Kawamoto
        愛知学院大学歯学会第91回学術大会, 03 Dec. 2017, Invited
      • iPS細胞技術を用いたがん抗原特異的キラーT細胞の再生 —ネオアンチゲンを標的とした個別化医療への応用—
        Hiroshi Kawamoto
        第23回国際個別化医療学会学術集会, 28 Oct. 2017, Invited
      • T細胞の発生と再生 -iPS細胞技術を用いたがん抗原特異的キラーT細胞の再生-
        Hiroshi Kawamoto
        Sapporo Stem Cell Conference2017, 10 Aug. 2017
      • iPS細胞技術を用いたがん抗原特異的キラーT細胞の再生 ー他家移植の系で使えるT細胞製剤の開発ー
        Hiroshi Kawamoto
        日本肝癌研究会, 06 Jul. 2017, Invited
      • Regeneration of CD8αβ type T cells with potent tumor antigen-specific cytotoxic activity from T cell-derived iPSCs
        Hiroshi Kawamoto
        日本がん免疫学会総会シンポジウム, 29 Jun. 2017, Invited
      • Generation and Regeneration of T cells
        Hiroshi Kawamoto
        The Molecular Developmental Biology of Lymphocytes, 20 Apr. 2017, Invited
      • 造血幹細胞からT 前駆細胞に至る系列決定の過程
        河本宏
        日本造血細胞移植学会総会教育講演(2012.2.24. 大阪), 2012
      • 造血における前駆細胞の系列決定の過程
        河本宏
        日本免疫学会サマースクール免疫学会賞受賞記念講義 (2012.7.26.那須), 2012
      • 造血液細胞の新しい分化モデル
        河本宏
        北野病院コアレクチャー(2012.7.30.大阪), 2012
      • 新しい造血モデルによる古典的概念からの脱却
        河本宏
        大阪大学医療組織工学フォーラム(2012.12.3.大阪), 2012
      • 血液細胞の新しい分化モデル~古典的なミエロイド系/リンパ系二分法の概念からの脱却~
        河本宏
        河本宏(京都大学再生医科学研究所教授) 「再生医学・再生医療の先端融合的共同研究拠点」 平成24 年度学術講演会 開催日:2012 年12 月19 日(水), 2012
      • Molecular mechanisms for production and maintenance of T cell lineage
        河本宏
        新学術領域「細胞運命制御」 国際シンポジウム(2012.11.6.京都), 2012
      • Epigenetic mechanisms maintaining the T cell and thymic epithelial cell lineage
        河本宏
        日本免疫学会学術集会 シンポジウム「Lymphocyte development」(2012.12.5.神戸) Institute for Frontier Medical Sciences, 2012
      • 造血幹細胞からT 前駆細胞に至る系列決定の過程-分化停止/自己複製誘導による分化のチェックポイントの可視化-
        河本宏
        河本宏(理化学研究所免疫・アレルギー科学総合研究センター免疫発生研究チームチームリーダー) \n京都大学再生医科学研究所第1 回生命科学セミナー \n開催日:2010 年9 月7 日(火) \n場所:iPS 細胞研究所1 階講堂, 2010
      • 強毒・弱毒SHIV の感染初期における胸腺組織及び胸腺内T 前駆細胞の解析
        元原麻貴子; 伊吹謙太郎; 三宅在子; 深澤嘉伯; 稲葉一寿; 鈴木元; 増田恭子; 河本宏; 仲宗根正; 本多三男; 速水正憲; 三浦智行
        第19回日本エイズ学会、2005 年12 月1 日~3 日、熊本, 2005

      Books and Other Publications

      External funds: Kakenhi

      • Novel diagnostic and therapeutic strategies for ovarian cancer by investigation of cancer and host diversity
        Grant-in-Aid for Scientific Research (B)
        Basic Section 56040:Obstetrics and gynecology-related
        Kyoto University
        万代 昌紀
        From 01 Apr. 2021, To 31 Mar. 2025, Granted
        婦人科腫瘍学;卵巣癌;腫瘍免疫;多様性
      • Understanding of non-genome replication during hematopoietic cell differentiation
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Institute of Physical and Chemical Research
        谷内 一郎
        From 28 Jun. 2019, To 31 Mar. 2024, Granted
        血球系細胞分化;非ゲノム情報;転写因子;エピジェネティックス;非ゲノム;血球系細胞;クロマチン;細胞分化;T細胞;エピジェネティクス;細胞形質;遺伝子発現制御;クロマチン構造
      • Mechanisms underlying replication of non-genomic codes that mediate plasticity and robustness for cellular inheritance
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        The University of Tokyo
        中西 真
        From 28 Jun. 2019, To 31 Mar. 2024, Granted
        非ゲノム情報複製;総括班研究;若手支援;技術支援;複製;DNAメチル化;ヒストン修飾;染色体高次構造;転写因子;非ゲノム情報
      • ヒト免疫細胞と再生組織を用いた自己免疫疾患モデルの樹立
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        河本 宏
        From 01 Apr. 2019, To 31 Mar. 2021, Project Closed
        自己免疫疾患発症モデル;NOGマウス;NOG-dKOマウス;PBMC;制御性T細胞;アロ反応;自己免疫疾患;モデルマウス;ヒト化マウス;iPS細胞
      • Development of a cell therapy for autoimmune diseases using monoclonal T cells specific for one target antigen
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49070:Immunology-related
        Kyoto University
        hiroshi kawamoto
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        制御性T細胞;自己免疫疾患;関節リウマチモデル;sk gマウス;RPL23a;関節リウマチ;T細胞レセプター;クローン;iPS細胞;間接リウマチ
      • 腫瘍浸潤リンパ球中のネオアンチゲン特異的CTLクローンの頻度計測と特製の解析
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        河本 宏
        From 01 Apr. 2017, To 31 Mar. 2019, Project Closed
        ネオアンチゲン;腫瘍浸潤Tリンパ球;T細胞レセプター;スフェロイド培養;大腸がん;免疫学;癌;再生医学
      • Analysis of the molecular basis of tertiary lymphoid tissue formation that results in age-related kidney vulnerability
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Motoko Yanagita
        From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
        炎症;加齢;線維化;老化;修復
      • Pathogenesis elucidation of seronegative spondyloarthritis using patient-derived iPSCs
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Hiroyuki Yoshitomi
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        iPS細胞;血清反応陰性脊椎関節炎;HLA B27;遺伝子編集;CRISPR-Cas9;CXCL13;血清反応陰性関節炎;強直性脊椎炎;ゲノム編集
      • Trial to develop a personalized adoptive immunotherapy
        Grant-in-Aid for Scientific Research (B)
        Hiroshima University
        Noboru Hattori
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        養子免疫療法;癌特異的変異抗原;腫瘍浸潤性Tリンパ球;癌細胞培養;スフェロイド培養;がん免疫療法;癌免疫療法;iPS細胞;細胞株樹立;癌組織浸潤リンパ球
      • Clarification of transcriptional network that drives T cell lineage specification
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        hiroshi kawamoto
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        多能前駆細胞;系列決定;転写因子;エピジェネティクス;T前駆細胞;ポリコム;Ring1A;Ring1B;PAX5;発生・分化;免疫学
      • Elucidating the mechanisms of kidney fibrosis and regeneration
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Motoko Yanagita
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        線維化;再生;炎症;老化;内科;再生医学;循環器;急性腎障害;慢性腎臓病;腎性貧血
      • Clarification of physiological developmental pathway of myeloid lineage cells
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Hiroshi KAWAMOTO
        From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
        系列決定;フェイトマッピング;エピジェネティクス;T細胞系列;B細胞系列;造血;分化経路;前駆細胞
      • Clarification of molecular mechanisms regulating lineage commitment taking place on the way from multipotent hematopoietic progenitors to unipotent T cell progenitors
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University;The Institute of Physical and Chemical Research
        Hiroshi KAWAMOTO
        From 01 Apr. 2010, To 31 Mar. 2015, Project Closed
        系列決定;転写因子;エピジェネティクス;T細胞系列;B細胞系列;免疫学;発生・分化;細胞・組織;遺伝子;分化停止;自己複製;チェックポイント;転写因子ネットワーク;T細胞分化;前駆細胞
      • Control of cell fate decision in the cells differentiating to multiple pathways in a step-by-step fashion
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        The University of Tokyo
        Toshio KITAMURA
        From 01 Apr. 2010, To 31 Mar. 2015, Project Closed
        細胞分化;エピジェネティクス;骨髄異形成症候群;細胞周期;遺伝子;核酸;発現制御;発生・分化;バイオテクノロジー;造血細胞;リンパ球
      • 胸腺上皮細胞系列への特化過程の分子機構の解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The Institute of Physical and Chemical Research
        河本 宏
        Project Closed
      • Clarification of whole scheme of developmental pathway in hematopiesis by fate mapping using a genetic marking system
        Grant-in-Aid for Scientific Research (B)
        The Institute of Physical and Chemical Research
        Hiroshi KAWAMOTO
        Project Closed
        造血;前駆細胞;系列決定;T細胞;ミエロイド系細胞;細胞分化;T前駆細胞;Notchシグナル;フェイトマッピング;Bcl11b;Bclllb;B前駆細胞
      • マウスES細胞を材料とした人工胸腺の開発
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The Institute of Physical and Chemical Research
        河本 宏
        Project Closed
        人工胸腺;ES細胞;Foxn1;内胚葉;胸腺上皮細胞
      • αβT細胞系列とγδT細胞系列への運命決定の分子機構の解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The Institute of Physical and Chemical Research
        河本 宏
        Project Closed
        αβT細胞;γδT細胞;系列決定;DLL1遺伝子;胸腺;組織培養;間葉系細胞株
      • 多発性骨髄腫のマクロファージ活性化と協調効果を示すiPSキラーCAR-Tの開発
        Grant-in-Aid for Scientific Research (C)
        Basic Section 54010:Hematology and medical oncology-related
        Fujita Health University
        三原 圭一朗
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        CAR-T;骨髄腫;iPS-T細胞
      list
        Last Updated :2022/08/06

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          ILAS Seminar
          Z001, Spring, Institute for Liberal Arts and Sciences, 2
        • From Apr. 2013, To Mar. 2014
          Introduction to Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        • From Apr. 2013, To Mar. 2014
          Seminar on Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Regenerative medicine
          Fall, 総合生存学館
        • From Apr. 2014, To Mar. 2015
          Introduction to Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Seminar on Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Regenerative medicine
          Fall, 総合生存学館
        • From Apr. 2015, To Mar. 2016
          Seminar on Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Introduction to Developmental Biology and Regenerative Medicine
          Spring, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          ILAS Seminar
          Spring, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          Regenerative medicine
          Fall, 総合生存学館
        • From Apr. 2017, To Mar. 2018
          Regenerative medicine
          Fall, 総合生存学館
        • From 01 Apr. 2020, To 31 Mar. 2021
          B8 免疫学
          医学研究科

        Participation in PhD Defense

        • The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-derived iPS cells
          ITO TAKESHI, Graduate School of Medicine, Chief Examiner
          26 Jul. 2021
        • Generation of monkey iPS cell-derived cartilage lacking MHC class I molecules on the cell surface
          OKUTANI YUKI, Graduate School of Medicine, Sub-chief Examiner
          24 Jan. 2022
        • Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model
          MADHU MALINEE, Graduate School of Medicine, Sub-chief Examiner
          24 Jan. 2022
        • KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia
          IZUMI KIYOTAKA, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • Identification of the Minimum Requirements for Successful Haematopoietic Stem Cell Transplantation
          NISHI KATSUYUKI, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • Generation of hypoimmunogenic T cells from genetically engineered allogeneic iPS cells for off-the-shelf cancer immunotherapy
          BO WANG, Graduate School of Medicine, Chief Examiner
          24 May 2021
        • Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrinβ1-ILK-β-catenin-JUN axis
          YUZURIHA AKINORI, Graduate School of Medicine, Chief Examiner
          24 May 2021
        list
          Last Updated :2022/08/06

          Administration

          School management (title, position)

          • From 01 Apr. 2022, To 31 Mar. 2024
            研究活動上の行動規範に関する審査委員会委員 委員
          • From 01 Apr. 2022, To 31 Mar. 2024
            全学情報セキュリティ委員会 委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            研究倫理・安全推進委員会 委員
          • From 01 Apr. 2022
            研究公正委員会 委員
          • From 01 Apr. 2022, To 30 Sep. 2022
            総合技術部委員会 委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            研究科長部会
          • From 01 Apr. 2022, To 31 Mar. 2024
            部局長会議
          • From 01 Apr. 2022, To 31 Mar. 2024
            教育研究評議会 評議員
          • From 01 Apr. 2022, To 31 Mar. 2024
            医生物学系 学系長
          • From 01 Apr. 2022, To 31 Mar. 2024
            医生物学研究所 所長
          • From 11 Sep. 2013, To 10 Sep. 2015
            ヒトゲノム・遺伝子解析研究管理委員会 委員
          • From 01 Apr. 2015
            大学評価委員会点検・評価実行委員会 委員
          • From 11 Sep. 2015, To 31 Dec. 2015
            ヒトゲノム・遺伝子解析研究管理委員会 委員
          • From 01 Apr. 2016, To 31 Mar. 2018
            研究戦略タスクフォース プログラムオフィサー
          • From 01 Apr. 2015, To 30 Sep. 2016
            大学評価委員会点検・評価実行委員会 委員

          Faculty management (title, position)

          • From 01 Apr. 2022
            業績評価委員会 委員
          • From 01 Apr. 2022
            ウイルス・幹細胞システム医生物学共同研究拠点専門委員会 
          • From 01 Apr. 2018
            施設設備委員会 委員
          • From 01 Apr. 2022
            情報セキュリティ委員会 委員長
          • From 01 Apr. 2022
            放射線管理委員会 委員長
          • From 01 Jul. 2021
            再生実験動物施設飼育室施設運営委員会 委員
          • From 01 Apr. 2015, To 31 Mar. 2017
            副所長
          • 将来計画・評価委員会 委員
          • 予算委員会 委員
          • 安全衛生委員会
          • 再生医科学研究所、物質―細胞統合システム拠点及びiPS細胞研究所合同医の倫理委員会 委員
          • From 01 Oct. 2016
            動物実験委員会 委員
          • From 01 Oct. 2016, To 30 Jun. 2021
            再生医科学動物実験専門委員会 委員長
          • From 01 Oct. 2016
            安全衛生委員会 委員長
          • From 01 Oct. 2016
            医の倫理委員会 委員
          • From 01 Oct. 2016
            自己点検・評価委員会 委員長
          • From 01 Oct. 2016
            人権委員会 委員長
          • From 01 Apr. 2018
            研究データ保全委員会 委員長
          • From 01 Jun. 2017
            施設整備委員会
          • From 01 Oct. 2016
            再生医学・再生医療の先端融合的共同研究拠点専門委員会 委員長
          • From 01 Oct. 2016
            再生医学・再生医療の先端融合的共同研究拠点運営委員会 委員長
          • 3部局合同医の倫理委員会 委員

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