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Nobuyuki Kakiuchi

The HAKUBI Center for Advanced Research Program-Specific Associate Professor

Nobuyuki Kakiuchi
list
    Last Updated :2023/03/23

    Basic Information

    Faculty

    • 医学部

    Academic Degree

    • Doctor of Medical Science(Kyoto University)

    Language of Instruction

    • Japanese
    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2023/03/23

      Research

      Research Topics, Overview of the research

      • Research Topics

        Genomic analysis of tumorigenesis

      • Overview of the research

        Malignant cancers have mutations in cancer-associated genes. Recently, somatic mutations have been found in apparently normal tissues, which could drive malignant transformation. By analyzing somatic mutations in healthy tissues, we will elucidate the clonal dynamics in each organ.

      Research Areas

      • Life sciences, Gastroenterology
      • Life sciences, Tumor biology

      Papers

      • Germline DDX41 mutations define a unique subtype of myeloid neoplasms.
        Hideki Makishima; Ryunosuke Saiki; Yasuhito Nannya; Sophia Claire Korotev; Carmelo Gurnari; June Takeda; Yukihide Momozawa; Steven Best; Pramila Krishnamurthy; Tetsuichi Yoshizato; Yoshiko Atsuta; Yusuke Shiozawa; Yuka Iijima-Yamashita; Kenichi Yoshida; Yuichi Shiraishi; Yasunobu Nagata; Nobuyuki Kakiuchi; Makoto Onizuka; Kenichi Chiba; Hiroko Tanaka; Ayana Kon; Yotaro Ochi; Masahiro Marshall Nakagawa; Rurika Okuda; Takuto Mori; Akinori Yoda; Hidehiro Itonaga; Yasushi Miyazaki; Masashi Sanada; Takayuki Ishikawa; Shigeru Chiba; Hisashi Tsurumi; Senji Kasahara; Carsten Müller-Tidow; Akifumi Takaori-Kondo; Kazuma Ohyashiki; Toru Kiguchi; Fumihiko Matsuda; Joop H Jansen; Chantana Polprasert; Piers Blombery; Yoichiro Kamatani; Satoru Miyano; Luca Malcovati; Torsten Haferlach; Michiaki Kubo; Mario Cazzola; Austin G Kulasekararaj; Lucy A Godley; Jaroslaw P Maciejewski; Seishi Ogawa
        Blood, 02 Nov. 2022, Peer-reviewed
      • On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma.
        Ken Kumagai; Takahiro Shimizu; Mitsuhiro Nikaido; Tomonori Hirano; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Sachiko Minamiguchi; Takaki Sakurai; Mari Teramura; Takahiro Utsumi; Yukiko Hiramatsu; Yuki Nakanishi; Atsushi Takai; Shin'ichi Miyamoto; Seishi Ogawa; Hiroshi Seno
        The Journal of pathology, 10 Jan. 2023
      • 上部尿路上皮癌の分子分類と新規バイオマーカー
        藤井 陽一; 佐藤 悠佑; 鈴木 啓道; 吉里 哲一; 垣内 伸之; 吉田 健一; 千葉 健一; 白石 友一; 西松 寛明; 岡根谷 利一; 真田 昌; 南谷 泰仁; 牧島 秀樹; 宮野 悟; 久米 春喜; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • 骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Elucidating the mechanism of clonal evolution of DDX41 mutated cells in myeloid malignancies)
        昆 彩奈; 中川 正宏; 片岡 圭亮; 垣内 伸之; 牧島 秀樹; 越智 陽太郎; 中山 学; 古関 明彦; 南谷 泰仁; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
        中川 正宏; 稲垣 良作; 南谷 泰仁; 佐伯 龍之介; 越智 陽太郎; 竹田 淳恵; 趙 蘭英; 威 星星; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 正常乳管上皮細胞から乳癌に至るクローン進化
        西村 友美; 垣内 伸之; 吉田 健一; 竹内 康英; 前田 紘奈; 南谷 泰仁; 塩澤 裕介; 中川 正宏; 越智 陽太郎; 佐伯 龍之介; 片岡 竜貴; 桜井 孝規; 馬場 郷子; 白石 友一; 千葉 健一; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本乳癌学会総会プログラム抄録集, Jun. 2022
      • 正常乳管上皮細胞から乳癌に至るクローン進化
        西村 友美; 垣内 伸之; 吉田 健一; 竹内 康英; 前田 紘奈; 南谷 泰仁; 塩澤 裕介; 中川 正宏; 越智 陽太郎; 佐伯 龍之介; 片岡 竜貴; 桜井 孝規; 馬場 郷子; 白石 友一; 千葉 健一; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本乳癌学会総会プログラム抄録集, Jun. 2022
      • Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors
        Yuki Yamauchi; Yuzo Kodama; Masahiro Shiokawa; Nobuyuki Kakiuchi; Saiko Marui; Takeshi Kuwada; Yuko Sogabe; Teruko Tomono; Atsushi Mima; Toshihiro Morita; Tomoaki Matsumori; Tatsuki Ueda; Motoyuki Tsuda; Yoshihiro Nishikawa; Katsutoshi Kuriyama; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Atsuhiro Masuda; Hisato Tatsuoka; Daisuke Yabe; Sachiko Minamiguchi; Toshihiko Masui; Nobuya Inagaki; Shinji Uemoto; Tsutomu Chiba; Hiroshi Seno
        Cancer Research, 01 Sep. 2020, Peer-reviewed
      • A novel SREBF1::NACC1 gene fusion in a unclassifiable intracranial tumour.
        Yasuhide Takeuchi; Yohei Mineharu; Yoshiki Arakawa; Masayuki Hara; Yuki Oichi; Takahiko Kamata; Keita Fukuyama; Yoshihiro Yamamoto; Toshiyuki Yamanaka; Nobuyuki Kakiuchi; Emi Hiratomo; Masahiro Hirata; Hideaki Yokoo; Takanori Hirose; Sachiko Minamiguchi; Seishi Ogawa; Manabu Muto; Susumu Miyamoto; Hironori Haga
        Neuropathology and applied neurobiology, 28 Jul. 2022
      • 肝胆膵がんにおける基礎および臨床研究の進展 同時性・異時性多発膵癌の遺伝子解析
        平野 智紀; 垣内 伸之; 竹内 康英; 増井 俊彦; 白石 友一; 宮野 悟; 宇座 徳光; 田中 雄志; 増田 充弘; 児玉 裕三; 妹尾 浩; 千葉 勉; 小川 誠司
        日本癌学会総会記事, Sep. 2021
      • Genetic analysis of pheochromocytoma and paraganglioma complicating cyanotic congenital heart disease.
        Tatsuki Ogasawara; Yoichi Fujii; Nobuyuki Kakiuchi; Yusuke Shiozawa; Ryuichi Sakamoto; Yoshihiro Ogawa; Katsuki Ootani; Etsuro Ito; Tomoaki Tanaka; Kenichiro Watanabe; Yusaku Yoshida; Noriko Kimura; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seishi Ogawa
        The Journal of clinical endocrinology and metabolism, 22 Jun. 2022
      • The landscape of genetic aberrations in myxofibrosarcoma.
        Yasuhide Takeuchi; Kenichi Yoshida; Adriane Halik; Annegret Kunitz; Hiromichi Suzuki; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Yoshikage Inoue; Tomonori Hirano; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Yasuhito Nannya; Hideki Makishima; Berit Maria Pfitzner; Lars Bullinger; Masahiro Hirata; Keita Jinnouchi; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Takeshi Okamoto; Hironori Haga; Seishi Ogawa; Frederik Damm
        International journal of cancer, 29 Apr. 2022
      • A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial.
        K Hoyer; R Hablesreiter; Y Inoue; K Yoshida; F Briest; F Christen; N Kakiuchi; T Yoshizato; Y Shiozawa; Y Shiraishi; J K Striefler; S Bischoff; P Lohneis; H Putter; O Blau; U Keilholz; L Bullinger; U Pelzer; M Hummel; H Riess; S Ogawa; M Sinn; F Damm
        EBioMedicine, Apr. 2021
      • Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization.
        Ken Kumagai; Takahiro Shimizu; Atsushi Takai; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Tomonori Hirano; Haruhiko Takeda; Aya Mizuguchi; Mari Teramura; Takahiko Ito; Eriko Iguchi; Mitsuhiro Nikaido; Yuji Eso; Ken Takahashi; Yoshihide Ueda; Shin'ichi Miyamoto; Kazutaka Obama; Seishi Ogawa; Hiroyuki Marusawa; Hiroshi Seno
        Cancer research, 03 May 2022
      • Whole-genome landscape of adult T-cell leukemia/lymphoma
        Yasunori Kogure; Takuro Kameda; Junji Koya; Makoto Yoshimitsu; Kisato Nosaka; Jun ichirou Yasunaga; Yoshitaka Imaizumi; Mizuki Watanabe; Yuki Saito; Yuta Ito; Marni B. McClure; Mariko Tabata; Sumito Shingaki; Kota Yoshifuji; Kenichi Chiba; Ai Okada; Nobuyuki Kakiuchi; Yasuhito Nannya; Ayako Kamiunten; Yuki Tahira; Keiichi Akizuki; Masaaki Sekine; Kotaro Shide; Tomonori Hidaka; Yoko Kubuki; Akira Kitanaka; Michihiro Hidaka; Nobuaki Nakano; Atae Utsunomiya; R. Alejandro Sica; Ana Acuna-Villaorduna; Murali Janakiram; Urvi Shah; Juan Carlos Ramos; Tatsuhiro Shibata; Kengo Takeuchi; Akifumi Takaori-Kondo; Yasushi Miyazaki; Masao Matsuoka; Kenji Ishitsuka; Yuichi Shiraishi; Satoru Miyano; Seishi Ogawa; B. Hilda Ye; Kazuya Shimoda; Keisuke Kataoka
        Blood, 17 Feb. 2022
      • Whole-exome sequencing for a more accurate diagnosis of intraductal papillary neoplasms of the bile duct.
        Tomoaki Matsumori; Norimitsu Uza; Nobuyuki Kakiuchi; Toshihiro Morita; Yoshihiro Nishikawa; Masahiro Shiokawa; Kojiro Taura; Yuzo Kodama; Hiroshi Seno
        Gastroenterology report, 2022
      • 一細胞解像度のがん生物学 変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用
        中川 正宏; 稲垣 良作; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 吉里 哲一; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Sep. 2021
      • Distinct pathogenesis of clonal hematopoiesis revealed by single-cell sequencing(和訳中)
        中川 正宏; 稲垣 良作; 黒田 隆; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 吉里 哲一; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本血液学会学術集会, Sep. 2021
      • 乳管上皮増殖性病変から乳癌へ至るクローン進化
        西村 友美; 垣内 伸之; 吉田 健一; 竹内 康英; 前田 紘奈; 塩澤 裕介; 中川 正宏; 越智 陽太郎; 佐伯 龍之介; 川田 有希子; 片岡 竜貴; 桜井 孝規; 馬場 郷子; 白石 友一; 千葉 健一; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本乳癌学会総会プログラム抄録集, Jul. 2021
      • Correction: CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma.
        Toshihiro Morita; Yuzo Kodama; Masahiro Shiokawa; Katsutoshi Kuriyama; Saiko Marui; Takeshi Kuwada; Yuko Sogabe; Tomoaki Matsumori; Nobuyuki Kakiuchi; Teruko Tomono; Atsushi Mima; Tatsuki Ueda; Motoyuki Tsuda; Yuki Yamauchi; Yoshihiro Nishikawa; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Takashi Nagasawa; Tsutomu Chiba; Hiroshi Seno
        Cancer research, 15 Jun. 2021
      • 【炎症性腸疾患診療の新たな展開】炎症性腸疾患と発癌リスク
        濱田 健輔; 尾松 万悠紀; 北本 博規; 岡部 誠; 垣内 伸之; 中西 祐貴; 本澤 有介; 山本 修司; 妹尾 浩
        臨牀と研究, May 2021
      • Multiple pancreatic neuroendocrine tumors in OFCD syndrome caused by somatic BCOR mosaicism.
        Yuki Yamauchi; Yuzo Kodama; Nobuyuki Kakiuchi; Hiroshi Seno
        Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 04 Jan. 2022
      • The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy.
        Hidenari Hirata; Atsushi Niida; Nobuyuki Kakiuchi; Ryutaro Uchi; Keishi Sugimachi; Takaaki Masuda; Tomoko Saito; Shun-Ichiro Kageyama; Yushi Motomura; Shuhei Ito; Tadamasa Yoshitake; Daisuke Tsurumaru; Yusuke Nishimuta; Akira Yokoyama; Takanori Hasegawa; Kenichi Chiba; Yuichi Shiraishi; Junyan Du; Fumihito Miura; Masaru Morita; Yasushi Toh; Masakazu Hirakawa; Yoshiyuki Shioyama; Takashi Ito; Tetsuo Akimoto; Satoru Miyano; Tatsuhiro Shibata; Masaki Mori; Yutaka Suzuki; Seishi Ogawa; Kousei Ishigami; Koshi Mimori
        Cancer research, 01 Oct. 2021
      • 乳管上皮増殖性病変から乳癌へ至るクローン進化
        西村 友美; 垣内 伸之; 吉田 健一; 竹内 康英; 前田 紘奈; 塩澤 裕介; 中川 正宏; 越智 陽太郎; 佐伯 龍之介; 川田 有希子; 片岡 竜貴; 桜井 孝規; 馬場 郷子; 白石 友一; 千葉 健一; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本乳癌学会総会プログラム抄録集, Jul. 2021
      • Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development.
        Katsutoshi Kuriyama; Yuzo Kodama; Masahiro Shiokawa; Yoshihiro Nishikawa; Saiko Marui; Takeshi Kuwada; Yuko Sogabe; Nobuyuki Kakiuchi; Teruko Tomono; Tomoaki Matsumori; Atsushi Mima; Toshihiro Morita; Tatsuki Ueda; Motoyuki Tsuda; Yuki Yamauchi; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Ryoichiro Kageyama; Tsutomu Chiba; Hiroshi Seno
        Journal of gastroenterology, Jul. 2021
      • Molecular classification and diagnostics of upper urinary tract urothelial carcinoma.
        Yoichi Fujii; Yusuke Sato; Hiromichi Suzuki; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Andrew T Lenis; Shigekatsu Maekawa; Akira Yokoyama; Yasuhide Takeuchi; Yoshikage Inoue; Yotaro Ochi; Yusuke Shiozawa; Kosuke Aoki; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yasuhito Nannya; Hideki Makishima; Jimpei Miyakawa; Taketo Kawai; Teppei Morikawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Genta Nagae; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Tohru Nakagawa; Masashi Fukayama; Tetsuo Ushiku; Hiroyuki Aburatani; Satoru Miyano; Jonathan A Coleman; Yukio Homma; David B Solit; Haruki Kume; Seishi Ogawa
        Cancer cell, 14 Jun. 2021
      • A novel technique for mapping biopsy of bile duct cancer.
        Hirokazu Okada; Norimitsu Uza; Tomoaki Matsumori; Shimpei Matsumoto; Yuya Muramoto; Sakiko Ota; Takeharu Nakamura; Hiroyuki Yoshida; Tomonori Hirano; Takeshi Kuwada; Saiko Marui; Yuko Sogabe; Toshihiro Morita; Nobuyuki Kakiuchi; Atsushi Mima; Tatsuki Ueda; Yoshihiro Nishikawa; Motoyuki Tsuda; Takahisa Maruno; Masahiro Shiokawa; Ken Takahashi; Kojiro Taura; Sachiko Minamiguchi; Yuzo Kodama; Hiroshi Seno
        Endoscopy, Jun. 2021
      • Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis.
        Takeshi Kuwada; Masahiro Shiokawa; Yuzo Kodama; Sakiko Ota; Nobuyuki Kakiuchi; Yasuhito Nannya; Hajime Yamazaki; Hiroyuki Yoshida; Takeharu Nakamura; Shimpei Matsumoto; Yuya Muramoto; Shuji Yamamoto; Yusuke Honzawa; Katsutoshi Kuriyama; Kanako Okamoto; Tomonori Hirano; Hirokazu Okada; Saiko Marui; Yuko Sogabe; Toshihiro Morita; Tomoaki Matsumori; Atsushi Mima; Yoshihiro Nishikawa; Tatsuki Ueda; Kazuyoshi Matsumura; Norimitsu Uza; Tsutomu Chiba; Hiroshi Seno
        Gastroenterology, Jun. 2021
      • Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations.
        Mitsuhiro Nikaido; Nobuyuki Kakiuchi; Shin'ichi Miyamoto; Tomonori Hirano; Yasuhide Takeuchi; Taro Funakoshi; Akira Yokoyama; Tatsuki Ogasawara; Yoshihiro Yamamoto; Atsushi Yamada; Takeshi Setoyama; Takahiro Shimizu; Yukari Kato; Suguru Uose; Takaki Sakurai; Sachiko Minamiguchi; Kazutaka Obama; Yoshiharu Sakai; Manabu Muto; Tsutomu Chiba; Seishi Ogawa; Hiroshi Seno
        Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 07 May 2021
      • Unbiased Detection of Driver Mutations in Extramammary Paget Disease.
        Yoshihiro Ishida; Nobuyuki Kakiuchi; Kenichi Yoshida; Yoshikage Inoue; Hiroyuki Irie; Tatsuki R Kataoka; Masahiro Hirata; Takeru Funakoshi; Shigeto Matsushita; Hiroo Hata; Hiroshi Uchi; Yuki Yamamoto; Yasuhiro Fujisawa; Taku Fujimura; Ryunosuke Saiki; Kengo Takeuchi; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Atsushi Otsuka; Satoru Miyano; Kenji Kabashima; Seishi Ogawa
        Clinical cancer research : an official journal of the American Association for Cancer Research, 15 Mar. 2021
      • Frequent mutations in HLA and related genes in extranodal NK/T cell lymphomas.
        Chantana Polprasert; Yasuhide Takeuchi; Hideki Makishima; Kitsada Wudhikarn; Nobuyuki Kakiuchi; Nichthida Tangnuntachai; Thamathorn Assanasen; Wimonmas Sitthi; Hamidah Muhamad; Panisinee Lawasut; Sunisa Kongkiatkamon; Udomsak Bunworasate; Koji Izutsu; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seishi Ogawa; Kenichi Yoshida; Ponlapat Rojnuckarin
        Leukemia & lymphoma, Jan. 2021
      • Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma
        Tomoaki Matsumori; Yuzo Kodama; Atsushi Takai; Masahiro Shiokawa; Yoshihiro Nishikawa; Tomonori Matsumoto; Haruhiko Takeda; Saiko Marui; Hirokazu Okada; Tomonori Hirano; Takeshi Kuwada; Yuko Sogabe; Nobuyuki Kakiuchi; Teruko Tomono; Atsushi Mima; Toshihiro Morita; Tatsuki Ueda; Motoyuki Tsuda; Yuki Yamauchi; Katsutoshi Kuriyama; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Hiroyuki Marusawa; Ryoichiro Kageyama; Tsutomu Chiba; Hiroshi Seno
        Cancer Research, 01 Dec. 2020
      • Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia.
        Hiroo Ueno; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Yuka Iijima-Yamashita; Nobutaka Kiyokawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Tomoya Isobe; Masafumi Seki; Shunsuke Kimura; Hideki Makishima; Masahiro M Nakagawa; Nobuyuki Kakiuchi; Keisuke Kataoka; Tetsuichi Yoshizato; Dai Nishijima; Takao Deguchi; Kentaro Ohki; Atsushi Sato; Hiroyuki Takahashi; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Takeshi Inukai; Junko Takita; Toshihiko Imamura; Satoru Miyano; Atsushi Manabe; Keizo Horibe; Seishi Ogawa; Masashi Sanada
        Blood advances, 27 Oct. 2020
      • がんの一細胞生物学 骨髄系腫瘍の早期クローン進展の解析
        中川 正宏; 稲垣 良作; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • 粘液線維肉腫にみられるTP53の異常と著明な遺伝的不安定性
        竹内 康英; 鈴木 啓道; 吉田 健一; 白石 友一; 垣内 伸之; 塩澤 裕介; 井上 善景; 千葉 健一; 牧島 秀樹; 宮野 悟; 羽賀 博典; Damm Frederik; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • 乳がん微小環境の特性と全身性応答、新しい治療展開 乳管上皮増殖性病変から乳癌へ至るクローン進化
        西村 友美; 垣内 伸之; 吉田 健一; 竹内 康英; 前田 紘奈; 塩澤 裕介; 平田 勝啓; 片岡 竜貴; 桜井 孝規; 馬場 郷子; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • 異時性多発膵癌の遺伝子解析
        平野 智紀; 垣内 伸之; 竹内 康英; 増井 俊彦; 上本 伸二; 南口 早智子; 羽賀 博典; 白石 友一; 宮野 悟; 宇座 徳光; 児玉 裕三; 妹尾 浩; 千葉 勉; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • がんの一細胞生物学 骨髄系腫瘍の早期クローン進展の解析
        中川 正宏; 稲垣 良作; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • 乳がん微小環境の特性と全身性応答、新しい治療展開 乳管上皮増殖性病変から乳癌へ至るクローン進化
        西村 友美; 垣内 伸之; 吉田 健一; 竹内 康英; 前田 紘奈; 塩澤 裕介; 平田 勝啓; 片岡 竜貴; 桜井 孝規; 馬場 郷子; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma.
        Toshihiro Morita; Yuzo Kodama; Masahiro Shiokawa; Katsutoshi Kuriyama; Saiko Marui; Takeshi Kuwada; Yuko Sogabe; Tomoaki Matsumori; Nobuyuki Kakiuchi; Teruko Tomono; Atsushi Mima; Tatsuki Ueda; Motoyuki Tsuda; Yuki Yamauchi; Yoshihiro Nishikawa; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Takashi Nagasawa; Tsutomu Chiba; Hiroshi Seno
        Cancer research, 01 Oct. 2020
      • Rb and p53 execute distinct roles in the development of pancreatic neuroendocrine tumors.
        Yuki Yamauchi; Yuzo Kodama; Masahiro Shiokawa; Nobuyuki Kakiuchi; Saiko Marui; Takeshi Kuwada; Yuko Sogabe; Teruko Tomono; Atsushi Mima; Toshihiro Morita; Tomoaki Matsumori; Tatsuki Ueda; Motoyuki Tsuda; Yoshihiro Nishikawa; Katsutoshi Kuriyama; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Atsuhiro Masuda; Hisato Tatsuoka; Daisuke Yabe; Sachiko Minamiguchi; Toshihiko Masui; Nobuya Inagaki; Shinji Uemoto; Tsutomu Chiba; Hiroshi Seno
        Cancer research, 26 Jun. 2020, Peer-reviewed
      • Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.
        Yotaro Ochi; Ayana Kon; Toyonori Sakata; Masahiro M Nakagawa; Naotaka Nakazawa; Masanori Kakuta; Keisuke Kataoka; Haruhiko Koseki; Manabu Nakayama; Daisuke Morishita; Tatsuaki Tsuruyama; Ryunosuke Saiki; Akinori Yoda; Rurika Okuda; Tetsuichi Yoshizato; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Shinichi Kotani; Yasunori Kogure; Nobuyuki Kakiuchi; Tomomi Nishimura; Hideki Makishima; Luca Malcovati; Akihiko Yokoyama; Kengo Takeuchi; Eiji Sugihara; Taka-Aki Sato; Masashi Sanada; Akifumi Takaori-Kondo; Mario Cazzola; Mineko Kengaku; Satoru Miyano; Katsuhiko Shirahige; Hiroshi I Suzuki; Seishi Ogawa
        Cancer discovery, Jun. 2020
      • Tobacco smoking and somatic mutations in human bronchial epithelium.
        Kenichi Yoshida; Kate H C Gowers; Henry Lee-Six; Deepak P Chandrasekharan; Tim Coorens; Elizabeth F Maughan; Kathryn Beal; Andrew Menzies; Fraser R Millar; Elizabeth Anderson; Sarah E Clarke; Adam Pennycuick; Ricky M Thakrar; Colin R Butler; Nobuyuki Kakiuchi; Tomonori Hirano; Robert E Hynds; Michael R Stratton; Iñigo Martincorena; Sam M Janes; Peter J Campbell
        Nature, Feb. 2020, Peer-reviewed
      • Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.
        Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
        Nature, Jan. 2020, Peer-reviewed
      • Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling.
        Yosaku Watatani; Yasuharu Sato; Hiroaki Miyoshi; Kana Sakamoto; Kenji Nishida; Yuka Gion; Yasunobu Nagata; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Lanying Zhao; Yotaro Ochi; Yasuhide Takeuchi; June Takeda; Hiroo Ueno; Yasunori Kogure; Yusuke Shiozawa; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Masahiro M Nakagawa; Yasuhito Nanya; Kenichi Yoshida; Hideki Makishima; Masashi Sanada; Mamiko Sakata-Yanagimoto; Shigeru Chiba; Ryota Matsuoka; Masayuki Noguchi; Nobuhiro Hiramoto; Takayuki Ishikawa; Junichi Kitagawa; Nobuhiko Nakamura; Hisashi Tsurumi; Tatsuhiko Miyazaki; Yusuke Kito; Satoru Miyano; Kazuya Shimoda; Kengo Takeuchi; Koichi Ohshima; Tadashi Yoshino; Seishi Ogawa; Keisuke Kataoka
        Leukemia, Dec. 2019, Peer-reviewed
      • 発がん過程におけるゲノムと環境因子の相互作用 加齢に伴う食道上皮の遺伝子変異クローンによる再構築(Interactions between genomic and environmental factors during carcinogenesis Age-related remodeling of esophageal epithelia by mutated cancer drivers)
        横山 顕礼; 垣内 伸之; 吉里 哲一; 南谷 泰仁; 竹内 康英; 塩澤 祐介; 牧島 秀樹; 角田 茂; 眞田 昌; 宮野 悟; 武藤 学; 小川 誠司
        日本癌学会総会記事, Sep. 2019
      • がんゲノム解析の新しい流れ(全ゲノム解析、クラウド解析、全がん解析、ロングリード解析などの新規技術) POLE遺伝子変異を有する大腸癌の遺伝子変異解析(Frontiers in cancer genomics Clinical and genetic characteristics of colorectal cancer with POLE gene mutation)
        井上 善景; 垣内 伸之; 吉田 健一; 塩澤 裕介; 千葉 健一; 竹内 康英; 吉里 哲一; 長山 聡; 宮野 悟; 坂井 義治; 小川 誠司
        日本癌学会総会記事, Sep. 2019
      • 発がん過程におけるゲノムと環境因子の相互作用 加齢に伴う食道上皮の遺伝子変異クローンによる再構築(Interactions between genomic and environmental factors during carcinogenesis Age-related remodeling of esophageal epithelia by mutated cancer drivers)
        横山 顕礼; 垣内 伸之; 吉里 哲一; 南谷 泰仁; 竹内 康英; 塩澤 祐介; 牧島 秀樹; 角田 茂; 眞田 昌; 宮野 悟; 武藤 学; 小川 誠司
        日本癌学会総会記事, Sep. 2019, Peer-reviewed
      • がんゲノム解析の新しい流れ(全ゲノム解析、クラウド解析、全がん解析、ロングリード解析などの新規技術) POLE遺伝子変異を有する大腸癌の遺伝子変異解析(Frontiers in cancer genomics Clinical and genetic characteristics of colorectal cancer with POLE gene mutation)
        井上 善景; 垣内 伸之; 吉田 健一; 塩澤 裕介; 千葉 健一; 竹内 康英; 吉里 哲一; 長山 聡; 宮野 悟; 坂井 義治; 小川 誠司
        日本癌学会総会記事, Sep. 2019, Peer-reviewed
      • 粘液線維肉腫にみられるTP53の異常と著明な遺伝的不安定性(Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma)
        竹内 康英; 鈴木 啓道; 吉田 健一; 白石 友一; 垣内 伸之; 塩澤 裕介; 井上 善景; 千葉 健一; 牧島 秀樹; 宮野 悟; 羽賀 博典; Damm Frederik; 小川 誠司
        日本癌学会総会記事, Sep. 2019, Peer-reviewed
      • 乳管上皮増殖性病変から乳癌へ至るクローン進化(Clonal evolution of proliferative lesions into breast cancers)
        西村 友美; 吉田 健一; 竹内 康英; 垣内 伸之; 塩澤 裕介; 片岡 竜貴; 桜井 孝規; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本癌学会総会記事, Sep. 2019, Peer-reviewed
      • Genetic analysis of pancreatic neuroendocrine neoplasms grade 3
        Kakiuchi Nobuyuki; Yoshida Kenichi; Shiozawa Yusuke; Yokoyama Akira; Kataoka Keisuke; Inoue Yoshikage; Takeuchi Yasuhide; Hirano Tomonori; Fujii Yoichi; Ueno Hiroo; Hijioka Susumu; Mizuno Nobumasa; Hosoda Waki; Yatabe Yasushi; Chiba Kenichi; Tanaka Hiroko; Shiraishi Yuichi; Miyano Satoru; Masui Toshihiko; Uemoto Shinji; Yoshizawa Akihiko; Haga Hironori; Uza Norimitsu; Seno Hiroshi; Kodama Yuzo; Ogawa Seishi
        CANCER RESEARCH, Jul. 2019, Peer-reviewed
      • Genetic analysis of metachronous pancreatic cancers
        Tomonori Hirano; Kakiuchi Nobuyuki; Takeuchi Yasuhide; Inoue Yoshikage; Nishimura Tomomi; Fujii Yoichi; Yokoyama Akira; Makishima Hideki; Masui Toshihiko; Uemoto Shinji; Minamiguchi Sachiko; Haga Hironori; Chiba Kenichi; Tanaka Hiroko; Shiraishi Yuichi; Miyano Satoru; Uza Norimitsu; Kodama Yuzo; Seno Hiroshi; Chiba Tsutomu; Ogawa Seishi
        CANCER RESEARCH, Jul. 2019, Peer-reviewed
      • Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer.
        Taro Funakoshi; Shin'ichi Miyamoto; Nobuyuki Kakiuchi; Mitsuhiro Nikaido; Takeshi Setoyama; Akira Yokoyama; Takahiro Horimatsu; Atsushi Yamada; Masako Torishima; Shinji Kosugi; Hidetaka Yamada; Haruhiko Sugimura; Hironori Haga; Yoshiharu Sakai; Seishi Ogawa; Hiroshi Seno; Manabu Muto; Tsutomu Chiba
        Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, Jul. 2019, Peer-reviewed
      • Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas.
        Kataoka K; Miyoshi H; Sakata S; Dobashi A; Couronné L; Kogure Y; Sato Y; Nishida K; Gion Y; Shiraishi Y; Tanaka H; Chiba K; Watatani Y; Kakiuchi N; Shiozawa Y; Yoshizato T; Yoshida K; Makishima H; Sanada M; Onozawa M; Teshima T; Yoshiki Y; Ishida T; Suzuki K; Shimada K; Tomita A; Kato M; Ota Y; Izutsu K; Demachi-Okamura A; Akatsuka Y; Miyano S; Yoshino T; Gaulard P; Hermine O; Takeuchi K; Ohshima K; Ogawa S
        Leukemia, Jul. 2019, Peer-reviewed
      • Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.
        Soo Ki Kim; Haruhiko Takeda; Atsushi Takai; Tomonori Matsumoto; Nobuyuki Kakiuchi; Akira Yokoyama; Kenichi Yoshida; Toshimi Kaido; Shinji Uemoto; Sachiko Minamiguchi; Hironori Haga; Yuichi Shiraishi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa; Hiroyuki Marusawa
        Journal of gastroenterology, Jul. 2019, Peer-reviewed
      • 食道癌に対するゲノム医療の可能性と方向性 加齢に伴う正常食道組織の遺伝子異常とがん化のメカニズム
        横山 顕礼; 垣内 伸之; 吉里 哲一; 竹内 康英; 角田 茂; 南口 早智子; 三森 功士; 宮野 悟; 武藤 学; 小川 誠司
        日本食道学会学術集会プログラム・抄録集, Jun. 2019, Peer-reviewed
      • Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis
        Yoshihiro Nishikawa; Yuzo Kodama; Masahiro Shiokawa; Tomoaki Matsumori; Saiko Marui; Katsutoshi Kuriyama; Takeshi Kuwada; Yuko Sogabe; Nobuyuki Kakiuchi; Teruko Tomono; Atsushi Mima; Toshihiro Morita; Tatsuki Ueda; Motoyuki Tsuda; Yuki Yamauchi; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Motonari Uesugi; Ryoichiro Kageyama; Tsutomu Chiba; Hiroshi Seno
        Oncogene, 30 May 2019, Peer-reviewed
      • 孤発例の皮下脂肪織炎様T細胞リンパ腫でも高頻度でTIM3の胚細胞変異を認める(Frequent germline mutations of TIM3 in sporadic subcutaneous panniculitis-like T-cell lymphoma)
        竹内 康英; Polprasert Chantana; 垣内 伸之; 真田 昌; 秋田 直洋; 白石 友一; 宮野 悟; Rojnuckarin Ponlapat; 小川 誠司; 牧島 秀樹
        日本病理学会会誌, Apr. 2019, Peer-reviewed
      • Molecular pathogenesis of disease progression in MLL-rearranged AML.
        Shinichi Kotani; Akinori Yoda; Ayana Kon; Keisuke Kataoka; Yotaro Ochi; Yusuke Shiozawa; Cassandra Hirsch; June Takeda; Hiroo Ueno; Tetsuichi Yoshizato; Kenichi Yoshida; Masahiro M Nakagawa; Yasuhito Nannya; Nobuyuki Kakiuchi; Takuji Yamauchi; Kosuke Aoki; Yuichi Shiraishi; Satoru Miyano; Takahiro Maeda; Jaroslaw P Maciejewski; Akifumi Takaori-Kondo; Seishi Ogawa; Hideki Makishima
        Leukemia, Mar. 2019, Peer-reviewed
      • Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma.
        Chantana Polprasert; Yasuhide Takeuchi; Nobuyuki Kakiuchi; Kenichi Yoshida; Thamathorn Assanasen; Wimonmas Sitthi; Udomsak Bunworasate; Arunrat Pirunsarn; Kitsada Wudhikarn; Panisinee Lawasut; Noppacharn Uaprasert; Sunisa Kongkiatkamon; Chatphatai Moonla; Masashi Sanada; Nobuhiro Akita; June Takeda; Yoichi Fujii; Hiromichi Suzuki; Yasuhito Nannya; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Ponlapat Rojnuckarin; Seishi Ogawa; Hideki Makishima
        Blood advances, 26 Feb. 2019, Peer-reviewed
      • Age-related remodelling of oesophageal epithelia by mutated cancer drivers.
        Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Ki Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Yoshitaka Nishikawa; Yusuke Amanuma; Shinya Ohashi; Ikuo Aoyama; Takahiro Horimatsu; Shin'ichi Miyamoto; Shigeru Tsunoda; Yoshiharu Sakai; Maiko Narahara; J B Brown; Yoshitaka Sato; Genta Sawada; Koshi Mimori; Sachiko Minamiguchi; Hironori Haga; Hiroshi Seno; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa
        Nature, Jan. 2019, Peer-reviewed
      • Clonally related diffuse large B-cell lymphoma and interdigitating dendritic cell sarcoma sharing MYC translocation.
        Yotaro Ochi; Nobuhiro Hiramoto; Tetsuichi Yoshizato; Yuichiro Ono; June Takeda; Yusuke Shiozawa; Kenichi Yoshida; Nobuyuki Kakiuchi; Yuichi Shiraishi; Hiroko Tanaka; Kenichi Chiba; Yasuhiro Kazuma; Sumie Tabata; Noboru Yonetani; Keiichiro Uehara; Daisuke Yamashita; Yukihiro Imai; Koji Nagafuji; Mitsunori Yamakawa; Satoru Miyano; Akifumi Takaori-Kondo; Seishi Ogawa; Takayuki Ishikawa
        Haematologica, Nov. 2018, Peer-reviewed
      • POLE遺伝子変異に起因する大腸癌の予後解析(Prognostic impact of POLE mutation in Colorectal Cancer)
        井上 善景; 垣内 伸之; 吉田 健一; 塩澤 裕介; 千葉 健一; 竹内 康英; 吉里 哲一; 長山 聡; 宮野 悟; 坂井 義治; 小川 誠司
        日本癌学会総会記事, Sep. 2018, Peer-reviewed
      • 食道病理学的正常部の上皮には、食道癌ドライバー遺伝子によって年齢依存のリモデリングが生じる(Age-related remodeling of apparently normal esophageal epithelia by common cancer drivers)
        横山 顕礼; 吉里 哲一; 垣内 伸之; 南谷 泰仁; 鈴木 啓道; 塩澤 裕介; 竹内 康英; 牧島 秀樹; 角田 茂; 真田 昌; 宮野 悟; 武藤 学; 小川 誠司
        日本癌学会総会記事, Sep. 2018, Peer-reviewed
      • 乳管上皮非悪性増殖性病変から乳癌へのクローン進化(Clonal evolution of non-malignant proliferative lesions into breast cancers)
        西村 友美; 吉田 健一; 竹内 康英; 垣内 伸之; 塩澤 裕介; 片岡 竜貴; 桜井 孝規; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本癌学会総会記事, Sep. 2018, Peer-reviewed
      • 粘液線維肉腫はTP53の異常と著明な遺伝的不安定性を特徴とする(Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability)
        竹内 康英; 鈴木 啓道; 吉田 健一; 白石 友一; 垣内 伸之; 塩澤 裕介; 吉里 哲一; 千葉 健一; 牧島 秀樹; 宮野 悟; 羽賀 博典; Damm Frederik; 小川 誠司
        日本癌学会総会記事, Sep. 2018, Peer-reviewed
      • Laminin 511 is a target antigen in autoimmune pancreatitis
        Masahiro Shiokawa; Yuzo Kodama; Kiyotoshi Sekiguchi; Takeshi Kuwada; Teruko Tomono; Katsutoshi Kuriyama; Hajime Yamazaki; Toshihiro Morita; Saiko Marui; Yuko Sogabe; Nobuyuki Kakiuchi; Tomoaki Matsumori; Atsushi Mima; Yoshihiro Nishikawa; Tatsuki Ueda; Motoyuki Tsuda; Yuki Yamauchi; Yojiro Sakuma; Takahisa Maruno; Norimitsu Uza; Tatsuaki Tsuruyama; Tsuneyo Mimori; Hiroshi Seno; Tsutomu Chiba
        Science Translational Medicine, 08 Aug. 2018, Peer-reviewed
      • The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.
        Motoyuki Tsuda; Akihisa Fukuda; Nilotpal Roy; Yukiko Hiramatsu; Laura Leonhardt; Nobuyuki Kakiuchi; Kaja Hoyer; Satoshi Ogawa; Norihiro Goto; Kozo Ikuta; Yoshito Kimura; Yoshihide Matsumoto; Yutaka Takada; Takuto Yoshioka; Takahisa Maruno; Yuichi Yamaga; Grace E Kim; Haruhiko Akiyama; Seishi Ogawa; Christopher V Wright; Dieter Saur; Kyoichi Takaori; Shinji Uemoto; Matthias Hebrok; Tsutomu Chiba; Hiroshi Seno
        The Journal of clinical investigation, 01 Aug. 2018, Peer-reviewed
      • Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice.
        Yojiro Sakuma; Yuzo Kodama; Takaaki Eguchi; Norimitsu Uza; Yoshihisa Tsuji; Masahiro Shiokawa; Takahisa Maruno; Katsutoshi Kuriyama; Yoshihiro Nishikawa; Yuki Yamauchi; Motoyuki Tsuda; Tatsuki Ueda; Tomoaki Matsumori; Toshihiro Morita; Teruko Tomono; Nobuyuki Kakiuchi; Atsushi Mima; Yuko Sogabe; Saiko Marui; Takeshi Kuwada; Akihiko Okada; Tomohiro Watanabe; Hiroshi Nakase; Tsutomu Chiba; Hiroshi Seno
        Scientific reports, 11 Jun. 2018, Peer-reviewed
      • DCIS治療の最適化 乳管上皮異型増殖性病変から乳癌へ至るクローン進化
        西村 友美; 吉田 健一; 川田 有希子; 竹内 康英; 垣内 伸之; 塩澤 裕介; 青木 恒介; 平田 勝啓; 片岡 竜貴; 桜井 孝規; 白石 友一; 千葉 健一; 竹内 賢吾; 羽賀 博典; 宮野 悟; 戸井 雅和; 小川 誠司
        日本乳癌学会総会プログラム抄録集, May 2018, Peer-reviewed
      • 粘液線維肉腫の遺伝子変異、腫瘍内多様性の検討(Comprehensive Analysis of Genetic Alterations and Intratumor Heterogeneity in Myxofibrosarcoma)
        竹内 康英; 鈴木 啓道; 吉田 健一; 垣内 伸之; 塩澤 裕介; 白石 友一; 牧島 秀樹; Damm Frederik; 羽賀 博典; 小川 誠司
        日本病理学会会誌, Apr. 2018, Peer-reviewed
      • Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma.
        Tomoya Isobe; Masafumi Seki; Kenichi Yoshida; Masahiro Sekiguchi; Yusuke Shiozawa; Yuichi Shiraishi; Shunsuke Kimura; Misa Yoshida; Yoshikage Inoue; Akira Yokoyama; Nobuyuki Kakiuchi; Hiromichi Suzuki; Keisuke Kataoka; Yusuke Sato; Tomoko Kawai; Kenichi Chiba; Hiroko Tanaka; Teppei Shimamura; Motohiro Kato; Akihiro Iguchi; Asahito Hama; Tomoaki Taguchi; Masaharu Akiyama; Junya Fujimura; Akiko Inoue; Tsuyoshi Ito; Takao Deguchi; Chikako Kiyotani; Tomoko Iehara; Hajime Hosoi; Akira Oka; Masashi Sanada; Yukichi Tanaka; Kenichiro Hata; Satoru Miyano; Seishi Ogawa; Junko Takita
        Cancer research, 15 Feb. 2018, Peer-reviewed
      • Early diagnosis of pancreatic necrosis based on perfusion CT to predict the severity of acute pancreatitis (vol 52, pg 1130, 2017)
        Yoshihisa Tsuji; Naoki Takahashi; Hiroyoshi Isoda; Koji Koizumi; Sho Koyasu; Miho Sekimoto; Yuichi Imanaka; Shujiro Yazumi; Masanori Asada; Yoshihiro Nishikawa; Hiroshi Yamamoto; Osamu Kikuchi; Tsukasa Yoshida; Tetsuro Inokuma; Shinji Katsushima; Naoki Esaka; Akihiro Okano; Chiharu Kawanami; Nobuyuki Kakiuchi; Masahiro Shiokawa; Yuzo Kodama; Ichiro Moriyama; Takafumi Kajitani; Yoshikazu Kinoshita; Tsutomu Chiba
        JOURNAL OF GASTROENTEROLOGY, Oct. 2017, Peer-reviewed
      • Early diagnosis of pancreatic necrosis based on perfusion CT to predict the severity of acute pancreatitis
        Yoshihisa Tsuji; Naoki Takahashi; Hiroyoshi Isoda; Koji Koizumi; Sho Koyasu; Miho Sekimoto; Yuichi Imanaka; Shujiro Yazumi; Masanori Asada; Yoshihiro Nishikawa; Hiroshi Yamamoto; Osamu Kikuchi; Tsukasa Yoshida; Tetsuro Inokuma; Shinji Katsushima; Naoki Esaka; Akihiro Okano; Chiharu Kawanami; Nobuyuki Kakiuchi; Masahiro Shiokawa; Yuzo Kodama; Ichiro Moriyama; Takafumi Kajitani; Yoshikazu Kinoshita; Tsutomu Chiba
        JOURNAL OF GASTROENTEROLOGY, Oct. 2017, Peer-reviewed
      • C型肝炎ウイルス排除後に発生する肝細胞癌の遺伝子異常
        竹田 治彦; 高井 淳; 金 秀基; 垣内 伸之; 妹尾 浩; 小川 誠司; 丸澤 宏之
        日本癌学会総会記事, Sep. 2017
      • 大腸癌における遺伝子異常の包括的解析
        井上 善景; 垣内 伸之; 吉田 健一; 塩澤 裕介; 千葉 健一; 片岡 圭亮; 竹内 康英; 吉里 哲一; 田中 洋子; 長山 聡; 宮野 悟; 坂井 義治; 小川 誠司
        日本癌学会総会記事, Sep. 2017, Peer-reviewed
      • DISTINCTIVE ROLE OF RB AND P53 IN THE DEVELOPMENT OF PANCREATIC NEUROENDOCRINE TUMORS
        Yuki Yamauchi; Yuzo Kodama; Yuko Sogabe; Takeshi Kuwada; Saiko Marui; Atsushi Mima; Teruko Tomono; Toshihiro Morita; Nobuyuki Kakiuchi; Tomoaki Matsumori; Yoshihiro Nishikawa; Tatsuki Ueda; Motoyuki Tsuda; Katsutoshi Kuriyama; Yojiro Sakuma; Takahisa Maruno; Masahiro Shiokawa; Norimitsu Uza; Hiroshi Seno
        GASTROENTEROLOGY, Apr. 2017, Peer-reviewed
      • Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation
        Tetsuichi Yoshizato; Yasuhito Nannya; Yoshiko Atsuta; Yusuke Shiozawa; Yuka Iijima-Yamashita; Kenichi Yoshida; Yuichi Shiraishi; Hiromichi Suzuki; Yasunobu Nagata; Yusuke Sato; Nobuyuki Kakiuchi; Keitaro Matsuo; Makoto Onizuka; Keisuke Kataoka; Kenichi Chiba; Hiroko Tanaka; Hiroo Ueno; Masahiro M. Nakagawa; Bartlomiej Przychodzen; Claudia Haferlach; Wolfgang Kern; Kosuke Aoki; Hidehiro Itonaga; Yoshinobu Kanda; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Torsten Haferlach; Yasushi Miyazaki; Keizo Horibe; Masashi Sanada; Satoru Miyano; Hideki Makishima; Seishi Ogawa
        BLOOD, Apr. 2017, Peer-reviewed
      • Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children.
        M Kato; S Ishimaru; M Seki; K Yoshida; Y Shiraishi; K Chiba; N Kakiuchi; Y Sato; H Ueno; H Tanaka; T Inukai; D Tomizawa; D Hasegawa; T Osumi; Y Arakawa; T Aoki; M Okuya; K Kaizu; K Kato; Y Taneyama; H Goto; T Taki; M Takagi; M Sanada; K Koh; J Takita; S Miyano; S Ogawa; A Ohara; M Tsuchida; A Manabe
        Leukemia, Mar. 2017, Peer-reviewed
      • TERT promoter mutations and chromosome 8p loss are characteristic of nonalcoholic fatty liver disease-related hepatocellular carcinoma
        Soo Ki Kim; Yoshihide Ueda; Etsuro Hatano; Nobuyuki Kakiuchi; Haruhiko Takeda; Tomoyuki Goto; Takahiro Shimizu; Kenichi Yoshida; Yoshihiro Ikura; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Shinji Uemoto; Tsutomu Chiba; Seishi Ogawa; Hiroyuki Marusawa
        INTERNATIONAL JOURNAL OF CANCER, Dec. 2016, Peer-reviewed
      • Pathogenicity of IgG in patients with IgG4-related disease
        Masahiro Shiokawa; Yuzo Kodama; Katsutoshi Kuriyama; Kenichi Yoshimura; Teruko Tomono; Toshihiro Morita; Nobuyuki Kakiuchi; Tomoaki Matsumori; Atsushi Mima; Yoshihiro Nishikawa; Tatsuki Ueda; Motoyuki Tsuda; Yuki Yamauchi; Ryuki Minami; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Akira Kurita; Yugo Sawai; Yoshihisa Tsuji; Norimitsu Uza; Kazuyoshi Matsumura; Tomohiro Watanabe; Kenji Notohara; Tatsuaki Tsuruyama; Hiroshi Seno; Tsutomu Chiba
        GUT, Aug. 2016, Peer-reviewed
      • GENETIC LANDSCAPE OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA
        K. Yoshida; K. Chiba; Y. Okuno; N. Kakiuchi; S. Suzuki; H. Suzuki; R. Nakamoto-Matsubara; S. Koriyama; Y. Shiraishi; T. Yoshizato; Y. Shiozawa; K. Kataoka; H. Ueno; Y. Nagata; Y. Sato; H. Tanaka; A. Hayano; J. Homma; J. Fukai; K. Kajiwara; M. Ideguchi; Y. Komohara; N. Yajima; N. Tsuchiya; M. Sano; M. Nitta; Y. Muragaki; M. Sakata-Yanagimoto; Y. Iwadate; H. Hondoh; K. Kashiwase; T. Shiina; S. Miyano; S. Chiba; R. Yamanaka; S. Ogawa
        HAEMATOLOGICA, Jun. 2016
      • Aberrant PD-L1 expression through 3 '-UTR disruption in multiple cancers
        Keisuke Kataoka; Yuichi Shiraishi; Yohei Takeda; Seiji Sakata; Misako Matsumoto; Seiji Nagano; Takuya Maeda; Yasunobu Nagata; Akira Kitanaka; Seiya Mizuno; Hiroko Tanaka; Kenichi Chiba; Satoshi Ito; Yosaku Watatani; Nobuyuki Kakiuchi; Hiromichi Suzuki; Tetsuichi Yoshizato; Kenichi Yoshida; Masashi Sanada; Hidehiro Itonaga; Yoshitaka Imaizumi; Yasushi Totoki; Wataru Munakata; Hiromi Nakamura; Natsuko Hama; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Takuro Kameda; Kyoko Masuda; Nagahiro Minato; Koichi Kashiwase; Koji Izutsu; Akifumi Takaori-Kondo; Yasushi Miyazaki; Satoru Takahashi; Tatsuhiro Shibata; Hiroshi Kawamoto; Yoshiki Akatsuka; Kazuya Shimoda; Kengo Takeuchi; Tsukasa Seya; Satoru Miyano; Seishi Ogawa
        NATURE, Jun. 2016, Peer-reviewed
      • Diagnostic Performance of a New "Earpick-type Endoscopic Scraper" for Malignant Biliary Stricture: A Multicenter Prospective Study
        Yojiro Sakuma; Yuzo Kodama; Yuko Sogabe; Nobuyuki Kakiuchi; Hajime Honjo; Chiharu Kawanami; Kotaro Watanabe; Kenshiro Hirohashi; Yoshitaka Nakai; Yukitaka Yamashita; Sakae Mikami; Yukimasa Yamashita; Kozo Kajimura; Kazuki Ikeda; Hiroyuki Tamaki; Satoru Iwamoto; Fumihiro Matsuda; Koichi Fujita; Maya Minami; Yugo Sawai; Norimitsu Uza; Takashi Kawamura; Shinji Uemoto; Tsutomu Chiba; Shujiro Yazumi
        GASTROINTESTINAL ENDOSCOPY, May 2016, Peer-reviewed
      • Role of Activation-Induced Cytidine Deaminase (Aid) in Pancreatic Cancer Development
        Yuji Ota; Yuzo Kodama; Yugo Sawai; Nobuyuki Kakiuchi; Teruko Tomono; Tomoaki Matsumori; Atsushi Mima; Yuki Yamauchi; Yoshihiro Nishikawa; Motoyuki Tsuda; Katsutoshi Kuriyama; Yojiro Sakuma; Tatsuki Ueda; Takahisa Maruno; Masahiro Shiokawa; Norimitsu Uza; Hiroyuki Marusawa; Hiroshi Seno; Tsutomu Chiba
        GASTROENTEROLOGY, Apr. 2016, Peer-reviewed
      • Biphasic Role of HES1 in Pancreatic Development
        Katsutoshi Kuriyama; Yuzo Kodama; Masahiro Shiokawa; Nobuyuki Kakiuchi; Tomoaki Matsumori; Atsushi Mima; Teruko Tomono; Yoshihiro Nishikawa; Motoyuki Tsuda; Tatsuki Ueda; Yuki Yamauchi; Yojiro Sakuma; Yuji Ota; Takahisa Maruno; Norimitsu Uza; Hiroshi Seno; Tsutomu Chiba
        GASTROENTEROLOGY, Apr. 2016, Peer-reviewed
      • A case of adenosquamous carcinoma of the pancreas head with rapid growing feature
        HANAMOTO Koichi; YOGO Akitada; MATSUBAYASHI Jun; KITO Yoshinori; URA Katsuaki; TAIRA Kaoru; OE Hideaki; YOSHIKAWA Akira; ISHIGAMI Shun-ichi; KAKIUCHI Nobuyuki; SHIRASE Tomoyuki; DOI Ryuichiro
        Suizo, 25 Apr. 2013
      • A case of endocrine carcinoma of the cecum treated with CDDP/VP-16
        Shuji Hiramoto; Ayako Mizota; Akira Yoshioka; Chikage Zaima; Yuko Sogabe; Nobuhiro Hieda; Yoshihiro Nishida; Aya Mizuguchi; Nobuyuki Kakiuchi; Yasuhiro Matsunaga; Satoki Yasumura; Katsutoshi Kuhyama; Kentaro Hidaka; Wataru Tanabe; Hajime Honjo; Kazunori Hasegawa; Masahiko Kondo; Koji Nishikawa; Naoki Miyake; Chiharu Kawanami; Tomoyuki Shirase
        Japanese Journal of Cancer and Chemotherapy, 2012, Peer-reviewed

      Misc.

      • Clinical Impacts of Germline DDX41 Mutations on Myeloid Neoplasms
        Hideki Makishima; Yasuhito Nannya; June Takeda; Yukihide Momozawa; Ryunosuke Saiki; Tetsuichi Yoshizato; Yoshiko Atsuta; Yuka Iijima-Yamashita; Kenichi Yoshida; Yuichi Shiraishi; Yasunobu Nagata; Yusuke Shiozawa; Makoto Onizuka; Kenichi Chiba; Hiroko Tanaka; Nobuyuki Kakiuchi; Yotaro Ochi; Hiroo Ueno; Hidehiro Itonaga; Yoshinobu Kanda; Masashi Sanada; Ayana Kon; Yasushi Miyazaki; Keizo Horibe; Magnus Tobiasson; Hisashi Tsurumi; Senji Kasahara; Chantana Polprasert; Eva Hellstrom Lindberg; Akifumi Kondo Takaori; Toru Kiguchi; Mario Cazzola; Fumihiko Matsuda; Kazuma Ohyashiki; Jaroslaw P. Maciejewski; Torsten Haferlach; Yoichiro Kamatani; Michiaki Kubo; Satoru Miyano; Seishi Ogawa
        BLOOD, Nov. 2020
      • A Novel Prediction Model Integrating Genomic and Clinical Features in Pediatric B-Progenitor Acute Lymphoblastic Leukemia
        Hiroo Ueno; Kenichi Yoshida; Yasuhito Nannya; Yuka Iijima; Yusuke Shiozawa; Yuichi Shiraishi; Tomomi Ishida; Hiroyuki Tsukamoto; Keisuke Kataoka; Tetsuichi Yoshizato; Hideki Makishima; Nobuyuki Kakiuchi; Masafumi Seki; Mayumi Kibe; Hiroko Tanaka; Kenichi Chiba; Takao Deguchi; Atsushi Sato; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Toshihiko Imamura; Satoru Miyano; Seishi Ogawa; Keizo Horibe; Masashi Sanada
        PEDIATRIC BLOOD & CANCER, Nov. 2017
      • 変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用
        中川正宏; 稲垣良作; 南谷泰仁; 趙蘭英; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 吉里哲一; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司; 小川誠司; 小川誠司
        日本癌学会学術総会抄録集(Web), 2021
      • 胆嚢癌との鑑別診断に苦慮したPET陽性胆嚢炎の1切除例
        平良 薫; 松林 潤; 垣内 伸之; 友野 輝子; 本庶 元; 土井 隆一郎
        胆道, Aug. 2014
      • 特発性胆汁性腹膜炎の1例
        平良 薫; 垣内 伸之; 本庶 元; 土井 隆一郎
        胆道, Aug. 2012
      • Genetic analysis of metachronous pancreatic cancers
        Tomonori Hirano; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Toshihiko Masui; Shinji Uemoto; Sachiko Minamiguchi; Hironori Haga; Yuichi Shiraishi; Satoru Miyano; Norimitsu Uza; Yuzo Kodama; Hiroshi Seno; Tsutomu Chiba; Seishi Ogawa
        CANCER SCIENCE, Feb. 2021
      • Clonal evolution of proliferative lesions into breast cancers
        Tomomi Nishimura; Nobuyuki Kakiuchi; Kenichi Yoshida; Yasuhide Takeuchi; Hirona Maeda; Yusuke Shiozawa; Masahiro Hirata; Tatsuki R. Kataoka; Takaki Sakurai; Satoko Baba; Kengo Takeuchi; Hironori Haga; Satoru Miyano; Masakazu Toi; Seishi Ogawa
        CANCER SCIENCE, Feb. 2021
      • Early Clonal evolution of myeloid malignancies
        Masahiro Nakagawa; Ryosaku Inagaki; Yasuhito Nannya; Lanying Zhao; Yotaro Ochi; June Takeda; Xingxing Qi; Akinori Yoda; Ayana Kon; Nobuyuki Kakiuchi; Hideki Makishima; Shinichi Matsuda; Seishi Ogawa
        CANCER SCIENCE, Feb. 2021
      • Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma
        Yasuhide Takeuchi; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Nobuyuki Kakiuchi; Yusuke Shiozawa; Yoshikage Inoue; Kenichi Chiba; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
        CANCER SCIENCE, Feb. 2021
      • Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method
        Masahiro Marshall Nakagawa; Ryosaku Inagaki; Yutaka Kuroda; Yasuhito Nannya; Lanying Zhao; Yotaro Ochi; June Takeda; Qi Xingxing; Akinori Yoda; Ayana Kon; Nobuyuki Kakiuchi; Hideki Makishima; Shuichi Matsuda; Seishi Ogawa
        BLOOD, Nov. 2020
      • Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability
        Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Akaki Kotaro; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Tomonori Hirano; Yasuhide Takeuchi; Hiroyuki Miyoshi; Yoshiharu Sakai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
        CANCER RESEARCH, Aug. 2020
      • Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma
        Yasuhide Takeuchi; Annegret Kunitz; Adriane Halik; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Yoshikage Inoue; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Yasuhito Nannya; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
        CANCER RESEARCH, Aug. 2020
      • Genetic analysis of metachronous pancreatic cancers
        Hirano Tomonori; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Yoshikage Inoue; Tomomi Nishimura; Yoichi Fujii; Akira Yokoyama; Hideki Makishima; Toshihiko Masui; Shinji Uemoto; Sachiko Minamiguchi; Hironori Haga; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Satoru Miyano; Norimitsu Uza; Yuzo Kodama; Hiroshi Seno; Seishi Ogawa
        CANCER RESEARCH, Aug. 2020
      • 単一細胞でのRNA/DNA同時シーケンスによるクローン造血の病態解明
        中川正宏; 中川正宏; 稲垣良作; 稲垣良作; 稲垣良作; 黒田隆; 南谷泰仁; 趙蘭英; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司; 小川誠司; 小川誠司
        日本血液学会学術集会抄録(Web), 2020
      • Clonal expansion in bile duct associated with chronic inflammation
        前田紘奈; 前田紘奈; 垣内伸之; 平野智紀; 平野智紀; 竹内康英; 竹内康英; 伊藤孝司; 小川絵里; 塩川雅広; 宇座徳光; 田中洋子; 南谷泰仁; 牧島秀樹; 上本伸二; 宮野悟; 小川誠司; 小川誠司; 小川誠司
        日本癌学会学術総会抄録集(Web), 2020
      • Frequent mutational alterations to evade the immune system in colorectal cancer with POLE gene mutation
        井上善景; 垣内伸之; 吉田健一; 塩澤裕介; 竹内康英; 竹内康英; 千葉健一; 吉里哲一; 長山聡; 宮野悟; 坂井義治; 小川誠司; 小川誠司; 小川誠司
        日本癌学会学術総会抄録集(Web), 2020
      • Clonal evolution of non-malignant proliferative lesions into breast cancers
        Tomomi Nishimura; Kenichi Yoshida; Yukiko Kawata; Yasuhide Takeuchi; Nobuyuki Kakiuchi; Yusuke Shiozawa; Kosuke Aoki; Masahiro Hirata; Tatsuki R. Kataoka; Takaki Sakurai; Satoko Baba; Yuichi Shiraishi; Kenichi Chiba; Kengo Takeuchi; Hironori Haga; Satoru Miyano; Masakazu Toi; Seishi Ogawa
        CANCER RESEARCH, Jul. 2019
      • Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability
        Yasuhide Takeuchi; Annegret Kunitz; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Teppei Shimamura; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Yasuhito Nannya; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
        CANCER RESEARCH, Jul. 2019
      • Chronology and risk dependence of age-related remodelling of oesophageal epithelia
        Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M. Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Shinya Ohashi; Shin'ichi Miyamoto; Shigeru Tsunoda; Koshi Mimori; Sachiko Minamiguchi; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa
        CANCER RESEARCH, Jul. 2019
      • 膵神経内分泌腫瘍の病理とバイオマーカー 膵神経内分泌癌の網羅的ゲノム解析
        垣内 伸之; 宇座 徳光; 細田 和貴; 谷田部 恭; 桑原 崇通; 水野 伸匡; 児玉 裕三; 妹尾 浩; 小川 誠司
        膵臓, Jun. 2019
      • 膵神経内分泌癌の網羅的ゲノム解析
        垣内伸之; 宇座徳光; 細田和貴; 谷田部恭; 桑原崇通; 水野伸匡; 児玉裕三; 妹尾浩; 小川誠司
        膵臓(Web), 2019
      • 潰瘍性大腸炎における上皮細胞の陽性選択
        垣内伸之; 垣内伸之; 内野基; 木原多佳子; 赤木宏太朗; 井上善景; 長山聡; 横山顕礼; 平野智紀; 平野智紀; 竹内康英; 竹内康英; 越智陽太郎; 塩澤裕介; 片岡圭亮; 中川正宏; 依田成玄; 南谷泰仁; 牧島秀樹; 白石友一; 千葉健一; 真田昌; 三好弘之; 坂井義治; 桜井孝規; 羽賀博典; 廣田誠一; 池内浩基; 竹内理; 宮野悟; 妹尾浩; 小川誠司
        日本分子生物学会年会プログラム・要旨集(Web), 2019
      • Clinical and genetic characteristics of colorectal cancer with POLE gene mutation
        井上善景; 井上善景; 垣内伸之; 吉田健一; 塩澤裕介; 千葉建一; 竹内康英; 吉里哲一; 長山聡; 宮野悟; 坂井義治; 小川誠司
        日本癌学会学術総会抄録集(Web), 2019
      • Prognostic impact of POLE mutation in Colorectal Cancer
        Yoshikage Inoue; Nobuyuki Kakiuchi; Kenichi Yoshida; Yusuke Shiozawa; Kenichi Chiba; Yasuhide Takeuchi; Tetsuichi Yoshizato; Satoshi Nagayama; Satoru Miyano; Yoshiharu Sakai; Seishi Ogawa
        CANCER SCIENCE, Dec. 2018
      • Genetic Analysis of Pancreatic Neuroendocrine Neoplasms Grade 3
        Nobuyuki Kakiuchi; Tomonori Hirano; Yasuhide Takeuchi; Yusuke Shiozawa; Akihiko Yoshizawa; Yuichi Shiraishi; Satoru Miyano; Susumu Hijioka; Yasushi Yatabe; Hiroshi Seno; Yuzo Kodama; Seishi Ogawa
        CANCER SCIENCE, Dec. 2018
      • Clonal evolution of non-malignant proliferative lesions into breast cancers
        Tomomi Nishimura; Kenichi Yoshida; Yasuhide Takeuchi; Nobuyuki Kakiuchi; Yusuke Shiozawa; Tatsuki R. Kataoka; Takaki Sakurai; Kengo Takeuchi; Hironori Haga; Satoru Miyano; Masakazu Toi; Seishi Ogawa
        CANCER SCIENCE, Dec. 2018
      • Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability
        Yasuhide Takeuchi; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Nobuyuki Kakiuchi; Yusuke Shiozawa; Tetsuichi Yoshizato; Kenichi Chiba; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
        CANCER SCIENCE, Dec. 2018
      • Age-related remodeling of apparently normal esophageal epithelia by common cancer drivers
        Akira Yokoyama; Tetsuichi Yoshizato; Nobuyuki Kakiuchi; Yasuhito Nannya; Hiromichi Suzuki; Yusuke Shiozawa; Yasuhide Takeuchi; Hideki Makishima; Shigeru Tsunoda; Masashi Sanada; Satoru Miyano; Manabu Muto; Seishi Ogawa
        CANCER SCIENCE, Dec. 2018
      • The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia
        Hiroo Ueno; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Yuka Iijima-Yamashita; Nobutaka Kiyokawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Tomoya Isobe; Masafumi Seki; Shunsuke Kimura; Hideki Makishima; Nobuyuki Kakiuchi; Keisuke Kataoka; Tetsuichi Yoshizato; Hiroyuki Tsukamoto; Dai Nishijima; Takao Deguchi; Kentaro Ohki; Atsushi Sato; Hiroyuki Takahashi; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Takeshi Inukai; Junko Takita; Toshihiko Imamura; Satoru Miyano; Atsushi Manabe; Keizo Horibe; Seishi Ogawa; Masashi Sanada
        BLOOD, Nov. 2018
      • 膵神経内分泌腫瘍の治療戦略 網羅的ゲノム解析による膵神経内分泌癌の分子病態の解明と治療薬選択への展望
        垣内 伸之; 児玉 裕三; 小川 誠司
        日本消化器病学会雑誌, Oct. 2018
      • 膵神経内分泌癌の網羅的ゲノム解析(Genetic Analysis of Pancreatic Neuroendocrine Neoplasms Grade 3)
        垣内 伸之; 平野 智紀; 竹内 康英; 塩澤 裕介; 吉澤 明彦; 白石 友一; 宮野 悟; 肱岡 範; 谷田部 恭; 妹尾 浩; 児玉 裕三; 小川 誠司
        日本癌学会総会記事, Sep. 2018
      • Clonal evolution of atypical proliferative lesions into breast cancers
        Tomomi Nishimura; Kenichi Yoshida; Yukiko Kawata; Yasuhide Takeuchi; Nobuyuki Kakiuchi; Yusuke Shiozawa; Kosuke Aoki; Masahiro Hirata; Tatsuki R. Kataoka; Takaki Sakurai; Yuichi Shiraishi; Kenichi Chiba; Kengo Takeuchi; Hironori Haga; Satoru Miyano; Masakazu Toi; Seishi Ogawa
        CANCER RESEARCH, Jul. 2018
      • Comprehensive analysis of genetic alterations and intratumor heterogeneity in myxofibrosarcoma
        Yasuhide Takeuchi; Annegret Kunitz; Hiromichi Suzuki; Kenichi Yoshida; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Yoichi Fujii; Tetsuichi Yoshizato; Kosuke Aoki; Keisuke Kataoka; Yasuhito Nannya; Yuichi Shiraishi; Teppei Shimamura; Kenichi Chiba; Hiroko Tanaka; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
        CANCER RESEARCH, Jul. 2018
      • 遺伝性膵炎の原因と考えられる新規のPRSS1変異を同定した一例
        丸井彩子; 垣内伸之; 宇座徳光; 桑田威; 曽我部裕子; 友野輝子; 松森友昭; 森田敏広; 津田喬之; 西川義浩; 山内雄揮; 丸野貴久; 塩川雅広; 児玉裕三; 妹尾浩
        膵臓, May 2018
      • 消化器癌における個別化医療の進展 膵癌における遺伝子異常に基づく個別化医療を目指した取り組み
        平野 智紀; 垣内 伸之; 児玉 裕三
        日本消化器病学会雑誌, Mar. 2018
      • 膵癌における遺伝子異常に基づく個別化医療を目指した取り組み
        平野智紀; 垣内伸之; 児玉裕三
        日本消化器病学会雑誌(Web), 2018
      • 網羅的ゲノム解析による膵神経内分泌癌の分子病態の解明と治療薬選択への展望
        垣内伸之; 垣内伸之; 児玉裕三; 小川誠司
        Gastroenterological Endoscopy (Web), 2018
      • Differential role of mutations in clonal evolution of esophageal squamous cell mucosa
        Yokoyama Akira; Hiromichi Suzuki; Tetsuichi Yoshizato; Nobuyuki Kakiuchi; Yuusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Yasuhide Takeuchi; Shigeru Tsunonoda; Masashi Sanada; Satoru Miyano; Manabu Muto; Seishi Ogawa
        CANCER SCIENCE, Jan. 2018
      • Landscape of driver gene mutations in Stage II and Stage III Colorectal Cancer
        Yoshikage Inoue; Nobuyuki Kakiuchi; Kenichi Yoshida; Yusuke Shiozawa; Kenichi Chiba; Keisuke Kataoka; Yasuhide Takeuchi; Tetsuichi Yoshizato; Hiroko Tanaka; Satoshi Nagayama; Satoru Miyano; Yoshiharu Sakai; Seishi Ogawa
        CANCER SCIENCE, Jan. 2018
      • Comprehensive Sequencing Analysis in Subcutaneous Panniculitis-like T-Cell Lymphoma
        Chantana Polprasert; Yasuhide Takeuchi; Hideki Makishima; Nobuyuki Kakiuchi; Kenichi Yoshida; Keisuke Kataoka; Masashi Sanada; Nobuhiro Akita; Yuichi Shiraishi; Yusuke Shiozawa; Kenichi Chiba; Hiroko Tanaka; Thamathorn Assanasen; Wimonmas Sitthi; Arunrat Pirunsarn; Udomsak Bunworasate; Kitsada Wudhikarn; Panisinee Lawasut; Sunisa Kongkiatkamon; Satoru Miyano; Ponlapat Rojnuckarin; Seishi Ogawa
        BLOOD, Dec. 2017
      • Clinical Effect of Genetic Alterations in Pediatric Patients with B-Progenitor Acute Lymphoblastic Leukemia
        Hiroo Ueno; Kenichi Yoshida; Yasuhito Nannya; Yuka Iijima-Yamashita; Yusuke Shiozawa; Yuichi Shiraishi; Tomomi Ishida; Keisuke Kataoka; Tetsuichi Yoshizato; Hideki Makishima; Nobuyuki Kakiuchi; Masafumi Seki; Hiroko Tanaka; Kenichi Chiba; Takao Deguchi; Atsushi Sato; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Toshihiko Imamura; Satoru Miyano; Keizo Horibe; Seishi Ogawa; Masashi Sanada
        BLOOD, Dec. 2017
      • アルコール・タバコの慢性暴露による食道扁平上皮では、癌部と非癌部で異なるクローン選択を来す
        横山 顕礼; 鈴木 啓道; 吉里 哲一; 垣内 伸之; 塩澤 裕介; 佐藤 悠佑; 青木 恒介; 竹内 康英; 角田 茂; 真田 昌; 宮野 悟; 武藤 学; 小川 誠司
        日本癌学会総会記事, Sep. 2017
      • 慢性的なアルコール・タバコの暴露が関与する食道発癌メカニズム
        横山 顕礼; 垣内 伸之; 鈴木 啓道; 吉里 哲一; 青木 恒一; 竹内 康英; 天沼 裕介; 西川 佳孝; 大橋 真也; 青山 育雄; 堀松 高博; 宮本 心一; 角田 茂; 南口 早智子; 武藤 学; 小川 誠司
        日本消化器病学会雑誌, Sep. 2017
      • The genetic aberrations in carcinogenic sequence of colitis-associated cancer
        Nobuyuki Kakiuchi; Kenichi Yoshida; Yusuke Shiozawa; Akira Yokoyama; Keisuke Kataoka; Yoshikage Inoue; Yasuhide Takeuchi; Yasunori Kogure; Ayana Kon; Masahiro Nakagawa; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Satoru Miyano; Kenji Kawada; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Hiroshi Nakase; Motoi Uchino; Hiroki Ikeuchi; Takako Kihara; Seiichi Hirota; Takahiro Horimatsu; Minoru Matsuura; Hiroyuki Marusawa; Hiroshi Seno; Seishi Ogawa
        CANCER RESEARCH, Jul. 2017
      • Comprehensive genetic analysis of myxofibrosarcoma and comparison with other soft tissue sarcomas
        Yasuhide Takeuchi; Annegret Kunitz; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Teppei Shimamura; Kenichi Chiba; Hiroko Tanaka; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Hideki Makishima; Hironori Haga; Satoru Miyano; Frederik Damm; Seishi Ogawa
        CANCER RESEARCH, Jul. 2017
      • Differential role of mutations in clonal evolution in esophageal mucosa at risk for cancer
        Akira Yokoyama; Hiromichi Suzuki; Tetsuichi Yoshizato; Yuusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Yoichi Fujii; Hideki Makishima; Kenichi Yoshida; Keisuke Kataoka; Yaichi Shiraishi; Masashi Sanada; Shigeru Tsunoda; Sachiko Minamiguchi; Satoru Miyano; Manabu Muto; Seishi Ogawa
        CANCER RESEARCH, Jul. 2017
      • MOLECULAR HETEROGENEITY IN PERIPHERAL T-CELL LYMPHOMA NOT OTHERWISE SPECIFIED REVEALED BY COMPREHENSIVE MUTATIONAL PROFILING
        Y. Watatani; Y. Sato; K. Nishida; H. Miyoshi; Y. Shiraishi; K. Chiba; H. Tanaka; H. Ueno; N. Kakiuchi; Y. Shiozawa; T. Yoshizato; K. Yoshida; M. Sanada; S. Miyano; K. Ohshima; T. Yoshino; S. Ogawa; K. Kataoka
        HAEMATOLOGICA, Jun. 2017
      • Hes1は膵癌マウスモデルにおいて膵発癌を抑制する
        西川義浩; 児玉裕三; 桑田威; 丸井彩子; 曽我部裕子; 森田敏広; 垣内伸之; 美馬淳志; 松森友昭; 友野輝子; 上田樹; 津田喬之; 山内雄揮; 佐久間洋二朗; 栗山勝利; 丸野貴久; 塩川雅広; 宇座徳光; 妹尾浩
        すい臓, May 2017
      • 膵神経内分泌腫瘍形成におけるRb,p53の役割
        山内雄揮; 児玉裕三; 桑田威; 丸井彩子; 曽我部裕子; 森田敏広; 垣内伸之; 美馬淳志; 松森友昭; 友野輝子; 上田樹; 津田喬之; 西川義浩; 佐久間洋二朗; 栗山勝利; 丸野貴久; 塩川雅広; 宇座徳光; 妹尾浩
        すい臓, May 2017
      • Molecular Heterogeneity in Peripheral T-Cell Lymphoma Not Otherwise Specified Revealed By Comprehensive Mutational Profiling
        Yosaku Watatani; Yasuharu Sato; Kenji Nishida; Hiroaki Miyoshi; Yuichi Shiraishi; Kenichi Chiba; Tanaka Hiroko; Hiroo Ueno; Nobuyuki Kakiuchi; Yusuke Shiozawa; Tetsuichi Yoshizato; Kenichi Yoshida; Masashi Sanada; Satoru Miyano; Koichi Ohshima; Tadashi Yoshino; Seishi Ogawa; Keisuke Kataoka
        BLOOD, Dec. 2016
      • 中枢神経原発悪性リンパ腫におけるゲノム異常の全貌
        吉田 健一; 千葉 健一; 奥野 友介; 垣内 伸之; 鈴木 啓道; 白石 友一; 田中 洋子; 村垣 善浩; 椎名 隆; 宮野 悟; 千葉 滋; 山中 龍也; 小川 誠司
        日本癌学会総会記事, Oct. 2016
      • 食道癌ハイリスク群の食道粘膜では、遺伝子変異のclonal evolutionは癌化において異なった役割を担う
        横山 顕礼; 鈴木 啓道; 吉里 哲一; 塩澤 祐介; 佐藤 悠佑; 青木 恒介; 垣内 伸之; 竹内 康英; 角田 茂; 真田 昌; 宮野 悟; 武藤 学; 小川 誠司
        日本癌学会総会記事, Oct. 2016
      • 肝癌の発生母地としての肝硬変組織に潜在するゲノム異常
        金 秀基; 吉田 健一; 垣内 伸之; 上田 佳秀; 南口 早智子; 海道 利実; 白石 友一; 宮野 悟; 羽賀 博典; 上本 伸二; 妹尾 浩; 小川 誠司; 丸澤 宏之
        日本癌学会総会記事, Oct. 2016
      • 原発性中枢神経系リンパ腫のゲノム背景(Genetic landscape of primary central nervous system lymphoma)
        Yoshida Kenichi; Chiba Kenichi; Kakiuchi Nobuyuki; Okuno Yusuke; Suzuki Shingo; Suzuki Hiromichi; Matsubara-Nakamoto Rie; Koriyama Shunichi; Shiraishi Yuichi; Yoshizato Tetsuichi; Shiozawa Yusuke; Kataoka Keisuke; Ueno Hiroo; Tanaka Hiroko; Sakata-Yanagimoto Mamiko; Kashiwase Koichi; Shiina Takashi; Miyano Satoru; Chiba Shigeru; Yamanaka Ryuya; Ogawa Seishi
        臨床血液, Sep. 2016
      • Clonal evolution in noncancerous esophageal mucosa in normal and cancer-bearing individuals
        Akira Yokoyama; Hiromichi Suzuki; Tetsuichi Yoshizato; Kosuke Aoki; Yusuke Shiozawa; Youichi Fujii; Yusuke Sato; Nobuyuki Kakiuchi; Sugi Kin; Keisuke Kataoka; Kenichi Yoshida; Hideki Makishinna; Yusuke Annanuma; Shinya Oohashi; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; J. B. Brown; Masashi Sanada; Shigeru Tsunoda; Sachiko Minamiguchi; Yoshiharu Sakai; Hironori Haga; Tsutonne Chiba; Satoru Miyano; Manabu Muto; Seishi Ogawa
        CANCER RESEARCH, Jul. 2016
      • Chemokine CXCL16 Plays a Critical Role in the Development of Severe Acute Pancreatitis
        Yojiro Sakuma; Yuzo Kodama; Tomoaki Matsumori; Teruko Tomono; Nobuyuki Kakiuchi; Atsushi Mima; Yuki Yamauchi; Yoshihiro Nishikawa; Motoyuki Tsuda; Tatsuki Ueda; Katsutoshi Kuriyama; Takahisa Maruno; Yuji Ota; Masahiro Shiokawa; Yoshihisa Tsuji; Norimitsu Uza; Tomohiro Watanabe; Hiroshi Nakase; Hiroshi Seno; Tsutomu Chiba
        GASTROENTEROLOGY, Apr. 2016
      • Genetic Basis of Primary Central Nervous System Lymphoma
        Kenichi Yoshida; Rie Nakamoto-Matsubara; Kenichi Chiba; Yusuke Okuno; Nobuyuki Kakiuchi; Yuichi Shiraishi; Yusuke Sato; Hiromichi Suzuki; Tetsuichi Yoshizato; Yusuke Shiozawa; Keisuke Kataoka; Hiroo Ueno; June Takeda; Yasunobu Nagata; Hiroko Tanaka; Yasuo Iwadate; Hiroaki Hondoh; Junya Fukai; Koji Kajiwara; Makoto Idegechi; Yoshihiro Komohara; Yukihiko Fujii; Syunichi Kohriyama; Masayuki Nitta; Yoshiharu Muragaki; Mamiko Sakata-Yanagimoto; Shingo Suzuki; Takashi Shiina; Satoru Miyano; Shigeru Chiba; Yamanaka Ryuya; Seishi Ogawa
        BLOOD, Dec. 2015
      • 【消化器疾患と遺伝子異常】遺伝性膵炎と孤発性膵炎の遺伝子異常
        美馬 淳志; 垣内 伸之; 福田 晃久; 児玉 裕三
        分子消化器病, Sep. 2015
      • 胆石イレウスの1例
        伊藤 孝; 光吉 明; 中村 直人; 松林 潤; 余語 覚匡; 鬼頭 祥悟; 花本 浩一; 中山 雄介; 浦 克明; 平良 薫; 大江 秀明; 吉川 明; 石上 俊一; 土井 隆一郎; 垣内 伸之
        日本腹部救急医学会雑誌, Feb. 2012

      External funds: Kakenhi

      • Study on pathogenesis and cancer development in primary sclerosing cholangitis by genetic analysis of biliary epithelium
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 50:Oncology and related fields
        Kyoto University
        Nobuyuki Kakiuchi
        From 30 Jul. 2020, To 31 Mar. 2022, Project Closed
        原発性硬化性胆管炎;胆管がん;体細胞変異;陽性選択;クローン拡大;慢性炎症;ドライバー変異;クローン進化;遺伝子変異;オルガノイド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21543/
      • 食道がん化における初期のゲノム異常の解明-多発ヨード不染の網羅的ゲノム解析-
        Grant-in-Aid for Scientific Research (B)
        Basic Section 53010:Gastroenterology-related
        Kyoto University
        横山 顕礼
        From 01 Apr. 2020, To 31 Mar. 2023, Granted
        食道がん;上皮内腫瘍;網羅的ゲノム解析;がんの起源;食道扁平上皮がん;ヨード不染色;飲酒;喫煙;食道扁平上皮;ゲノム解析;老化;食道扁平上皮癌;リスク因子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03660/
      • Deciphering colorectal carcinogenesis by the genomic analysis of colorectal epithelial cells
        Grant-in-Aid for Scientific Research (B)
        Basic Section 50010:Tumor biology-related
        Kyoto University
        垣内 伸之
        From 01 Apr. 2020, To 31 Mar. 2023, Granted
        大腸がん;網羅的ゲノム解析;クローン進化;ドライバー遺伝子;バイオインフォマティクス;ゲノム異常;慢性炎症;前癌病変;クローン拡大;自然選択
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03513/
      • Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues
        Grant-in-Aid for Scientific Research (B)
        Basic Section 56010:Neurosurgery-related
        Kyoto University
        荒川 芳輝
        From 01 Apr. 2022, To 31 Mar. 2026, Granted
        グリオーマ;正常脳;IDH変異型クローン;先制医療;3次元的網羅的ゲノム解析
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03186/
      • ヒト食道上皮細胞の形質転換メカニズムの解明
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 50:Oncology and related fields
        Kyoto University
        垣内 伸之
        From 30 Jun. 2022, To 31 Mar. 2024, Granted
        食道がん;発がん;クローン進化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19457/

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