Basic Information

Email Address

• Email Address

  hsiao.suiwen.6jkyoto-u.ac.jp

Professional Memberships

• From Feb. 2026, To Present

  The Japan Neuroscience Society
• From May 2025, To Present

  Japanese Society for Chronobiology

Academic Degree

• 30 Jun. 2017

  M.S.（National Taiwan University）
• 21 Jan. 2022

  Ph.D.（Taipei Medical university）

Academic Resume (Graduate Schools)

• National Taiwan University, College of Public Health, Institute of Environmental Health, 修了
• Taipei Medical University, College of Pharmacy, Ph.D. Program in Drug Discovery and Development Industry, 修了

Academic Resume (Undergraduate School/Majors)

• National Taiwan University, College of Public Health, Department of Public Health, 卒業

Profile

• Profile

  2026年4月1日にシステムバイオロジー分野の助教に着任いたしました蕭 穗文（シャオ　スイウェン）と申します。

  
  

  私は台湾の国立台湾大学公衆衛生学院にて学士号と修士号を取得した後、台北医学大学薬学院にて博士の学位を取得しました。その後は2022年から京都大学大学院薬学研究科の土居雅夫教授の研究室にお世話になり、博士研究員として体内時計の神経制御機構に関する研究を行ってきました。

  
  

  これまで私は、LC-MS/MSや多次元LCを用いた代謝物解析および天然物分析の研究を行ってきました。多次元LCを用いたキラルアミノ酸の定量法の確立や、酵素や細胞を組み合わせた活性天然化合物のスクリーニング、そしてメタボローム解析によって生体内の代謝物変化の解析に取り組んできました。

  
  

  こうした研究を続ける中で、「体内時計がどのように生理機能や代謝に影響を与えるのか」という問いに関心を持ち、土居先生の研究室の一員として、新たな一歩を踏み出しました。現在は、時間中枢の神経制御回路の解明に挑んでいます。疎なラベル法を用いることで、体内時計の中枢である視交叉上核（SCN）の神経細胞を一つ一つ描き出し、それらの細胞がSCN内や脳全体においてどのような役割を果たしているのかを探求しています。

  
  

  京都大学の素晴らしい環境の中で、多くの優れた研究者の皆様と交流を深め、その真摯な研究姿勢や哲学を吸収しながら、自身の研究をさらに深めていきたいと考えています。また、研究室の学生の皆様とも、日々の議論や実験を通じて共に学び、お互いに大きく成長していけることを楽しみにしています。どうぞよろしくお願いいたします。

  
  

   

  
  

   

  
  

  My name is Sui-Wen Hsiao, and I am very glad to be working as an Assistant Professor in the Laboratory of Systems Biology from April 1, 2026.

  
  

  Originally from Taiwan, I obtained my Bachelor’s and Master’s degrees from the College of Public Health at National Taiwan University, and earned my Ph.D. from the College of Pharmacy at Taipei Medical University. Subsequently, since 2022, I have had the privilege of working as a postdoctoral researcher in Professor Masao Doi’s laboratory, where I conducted research focusing on the neural regulation of circadian rhythms.

  
  

  During my doctoral studies, my research centered on metabolite and natural product analysis using LC-MS/MS and multi-dimensional LC. Specifically, I worked on establishing quantification methods for chiral amino acids using multi-dimensional LC, screening bio-active natural compounds by integrating enzyme/cell platforms with LC-MS analysis, and analyzing in vivo metabolic changes through metabolomic analysis.

  
  

  Driven by a growing interest in how the circadian clock influences physiological functions and metabolism, I took a new step forward by joining Professor Doi’s laboratory. Currently, I am tackling the challenge of elucidating the neural regulatory circuits of the master circadian pacemaker, the suprachiasmatic nucleus (SCN). By utilizing our established sparse labeling method, I aim to visualize and analyze the morphology and projectome of SCN neurons at the single-cell level, investigating their unique roles both locally and throughout the whole brain.

  
  

  In the inspiring environment of Kyoto University, I look forward to collaborating with and drawing inspiration from the many outstanding researchers here to further advance my own research. I am also eager to mentor and grow together with the students in the laboratory through our day-to-day interactions in the lab. I am truly excited to contribute to this vibrant academic community.

researchmap URL

• https://researchmap.jp/sw-hsiao

Research

Research Interests

• Circadian rhythm
• Neuronal circuit
• suprachiasmatic nucleus (SCN)
• Two-dimensional HPLC
• spotted fever group rickettsiae
• Amino acid enantiomers
• Chiral separation
• Seroepidemiology
• Natural products
• Gut microbiome
• LC-MS/MS
• Metabolomics

Research Areas

• Life sciences, Animals: biochemistry, physiology, behavioral science, Systems Biology
• Life sciences, Animals: biochemistry, physiology, behavioral science, Metabolomics

Papers

• Heterogeneity between VIP and GRP neurons underlies AVP receptor signaling in the mouse suprachiasmatic nucleus

  Huihua Zhou; Daichi Moriyasu; Sui-Wen Hsiao; Yoshiaki Yamaguchi; Morio Azuma; Taka-aki Koshimizu; Keiichi Itoi; Kenji Sakimura; William J. Schwartz; Hitoshi Okamura; Emi Hasegawa; Masao Doi

  Communications Biology, 12 Feb. 2026

  
• Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics

  Sui-Wen Hsiao; Masao Doi

  International Review of Cell and Molecular Biology, 2024, Lead author

  
• Assessing the skin-whitening property of plant extracts from taiwanese species using zebrafish as a rapid screening platform

  Sui-Wen Hsiao; I-Chih Kuo; Li-Ling Syu; Tzong-Huei Lee; Chia-Hsiung Cheng; Hui-Ching Mei; Ching-Kuo Lee

  Arabian Journal of Chemistry, Sep. 2023, Lead author

  
• Anti-Aging Constituents from Pinus morrisonicola Leaves

  Ta-Wei Liu; Sui-Wen Hsiao; Chi-Ting Lin; George Hsiao; Ching-Kuo Lee

  Molecules, 28 Jun. 2023

  
• Nicotinamide mononucleotide for the potential treatment of age-associated dry eye disease

  Sui-Wen Hsiao; Masao Doi

  MEDCHEM NEWS, Feb. 2023, Lead author

  
• Cytotoxicity Effect of Constituents of Pinus taiwanensis Hayata Twigs on B16-F10 Melanoma Cells

  Man-Hsiu Chu; Sui-Wen Hsiao; Yu-Chen Kao; Hwa-Wen Yin; Yueh-Hsiung Kuo; Ching-Kuo Lee

  Molecules, 23 Apr. 2022

  
• Metabolite characterisation and profiling of Hermetia illucens L. larvae at various growth stages using Sesamum indicum residues as nutrient source

  S.-W. Hsiao; I-C. Kuo; C.-W. Su; Y.-H. Wang; H.-C. Mei; C.-K. Lee

  Journal of Insects as Food and Feed, 22 Mar. 2022, Lead author

  
• New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum

  Safwan Safwan; Shih-Wei Wang; George Hsiao; Sui-Wen Hsiao; Su-Jung Hsu; Tzong-Huei Lee; Ching-Kuo Lee

  Marine Drugs, 18 Jan. 2022

  
• Constituents of Aquilaria sinensis Leaves Upregulate the Expression of Matrix Metalloproteases 2 and 9

  Sui-Wen Hsiao; Yu-Chin Wu; Hui-Ching Mei; Yu-Hsin Chen; George Hsiao; Ching-Kuo Lee

  Molecules, 26 Apr. 2021, Lead author

  
• Determination of phenylalanine enantiomers in the plasma and urine of mammals and ᴅ-amino acid oxidase deficient rodents using two-dimensional high-performance liquid chromatography

  Sui-Wen Hsiao; Chiharu Ishii; Aogu Furusho; Chin-Ling Hsieh; Yukiko Shimizu; Takeyuki Akita; Masashi Mita; Tadashi Okamura; Ryuichi Konno; Tomomi Ide; Ching-Kuo Lee; Kenji Hamase

  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Jan. 2021, Lead author

  
• Seroepidemiological and molecular investigation of spotted fever group rickettsiae and Coxiella burnetii in Sao Tome Island: A One Health approach

  Ting‐En Hsi; Sui‐Wen Hsiao; Nicholas T. Minahan; Tsai‐Ying Yen; Arlindo Vicente Carvalho; Didier Raoult; Pierre‐Edouard Fournier; Kun‐Hsien Tsai

  Transboundary and Emerging Diseases, Jul. 2020, Lead author

  

Presentations

• Visualization of neuronal morphology of the suprachiasmatic nucleus vasopressin neurons by Cre/FLPe-based genetic two-step sparse labelling — GT-SPARCL

  Sui-Wen Hsiao

  Sapporo Symposium on Biological Rhythm 2026, 12 Sep. 2026

  
• Circadian intracrine activity governs age-associated meibomian gland dysfunction and evaporative dry eye disease

  Sui-Wen Hsiao; Doi Masao

  Asia Forum on Chronobiology, 11 Aug. 2024

  
• Circadian intracrine activity governs age-associated meibomian gland dysfunction and evaporative dry eye disease

  Sui-Wen Hsiao; Doi Masao

  Sapporo Symposium on Biological Rhythm, 09 Aug. 2024

  
• Determination of Phenylalanine Enantiomers in Mammalian Plasma and Urine Using Two-Dimensional HPLC

  Sui-Wen Hsiao; Chiharu Ishii; Aogu Furusho; Takeyuki Akita; Masashi Mita; Tomomi Ide; Ching-Kuo Lee; Kenji Hamase

  バイオメディカル分析科学シンポジウム(BMAS), 23 Aug. 2019

  
• Molecular and epidemiological study of spotted fever group rickettsiae in the Democratic Republic of Sao Tome and Principe

  Sui-Wen, Hsiao; Lien-Fen, Tseng; Wen-Jer, Wu; Hsi-Chieh, Wang; Kun-Hsien, Tsai

  Taiwan Entomological Society, 14 Oct. 2016

  
• Beating Malaria Together

  Sui-Wen, Hsiao; Pei-Rong, Lin; Kun-Hsien, Tsai

  Taiwan Public Health Association, 25 Oct. 2014

  
• Practical Work Internship of Malaria Control in São Tomé Principe

  Sui-Wen, Hsiao; Pei-Rong, Lin; Kun-Hsien, Tsai

  Taiwan Entomological Society, 18 Oct. 2014

  

Awards

• 15 Oct. 2016

  Postgraduate Thesis Speech Competition - Honorable Mention
• 25 Sep. 2014

  Internship Achievement Poster Contest - Merit Award(National Taiwan University)
• 31 Oct. 2013

  Presidential Award for the Department of Public Health

Media Coverage

• Professor Tsai Kun-Hsien's Team from the School of Public Health Honored with the Friend of Foreign Service Award for Their Exceptional Achievements in Malaria Control in African Allied Nations

  National Taiwan University, Spotlight, Website of National Taiwan University, Dec. 2016, Internet