Basic Information

Faculty

• Faculty of Medicine

Academic Degree

• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  201401082377881375

researchmap URL

• https://researchmap.jp/7000008833

Research

Research Topics, Overview of the research

• Research Topics

  Elucidation of the functions of non-coding RNA related to cardiovascular and metabolic diseases

Research Areas

• Life sciences, Metabolism and endocrinology
• Life sciences, Cardiology

Papers

• A Case of Fat Embolism Syndrome Treated with Methylprednisolone.

  Daisuke Baba; Yugo Yamashita; Yuki Fukuda; Kyohei Yamaji; Hiroki Shiomi; Takahiro Horie; Shin Watanabe; Koh Ono

  Internal medicine (Tokyo, Japan), 26 Dec. 2024

  
• Temporal trends in management strategies and clinical outcomes of venous thromboembolism in Japan from 2017 to 2023

  Wei Xiong; Yugo Yamashita; Toshiki Fukasawa; Chikashi Takeda; Hiroki Shiomi; Takahiro Horie; Koh Ono

  Journal of Cardiology, Mar. 2025

  
• Myocardial infarction due to non-bacterial thrombotic endocarditis in a patient with oligodendroglioma: an unusual presentation and diagnostic challenge—a case report

  Yuto Miura; Eri Kato; Hiroki Shiomi; Takahiro Horie; Koh Ono

  European Heart Journal - Case Reports, 01 Feb. 2025

  
• A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells

  Fuquan Zou; Osamu Baba; Takahiro Horie; Yasuhiro Nakashima; Shuhei Tsuji; Tomohiro Yamasaki; Chiharu Otani; Sijia Xu; Miyako Imanaka; Kazuki Matsushita; Keita Suzuki; Eitaro Kume; Hidenori Kojima; Qiuxian Qian; Kayo Kimura; Naoya Sowa; Akira Kakizuka; Koh Ono

  02 May 2024

  
• VERVE-101: a promising CRISPR-based gene editing therapy that reduces LDL-C and PCSK9 levels in HeFH patients

  Takahiro Horie; Koh Ono

  European Heart Journal - Cardiovascular Pharmacotherapy, 23 Feb. 2024

  
• KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels

  Shuhei Tsuji; Chiharu Otani; Takahiro Horie; Shin Watanabe; Osamu Baba; Naoya Sowa; Yuya Ide; Asami Kashiwa; Takeru Makiyama; Hirohiko Imai; Yasuhiro Nakashima; Tomohiro Yamasaki; Sijia Xu; Kazuki Matsushita; Keita Suzuki; Fuquan Zou; Eitaro Kume; Koji Hasegawa; Takeshi Kimura; Akira Kakizuka; Koh Ono

  Biomedicine & Pharmacotherapy, Jan. 2024

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• CRISPR-Cas9-guided amplification-free genomic diagnosis for familial hypercholesterolemia using nanopore sequencing.

  Sijia Xu; Hiroki Shiomi; Yugo Yamashita; Satoshi Koyama; Takahiro Horie; Osamu Baba; Masahiro Kimura; Yasuhiro Nakashima; Naoya Sowa; Koji Hasegawa; Ayako Suzuki; Yutaka Suzuki; Takeshi Kimura; Koh Ono

  PloS one, 2024

  
• Medium-Chain Triglycerides-Specific Appetite is Regulated by the β-oxidation of Medium-Chain Fatty Acids in the Liver.

  Tsugunori Maruyama; Sho Matsui; Ryosuke Kobayashi; Takuro Horii; Yasuo Oguri; Satoshi Tsuzuki; Takahiro Horie; Koh Ono; Izuho Hatada; Tsutomu Sasaki

  American journal of physiology. Endocrinology and metabolism, 10 Apr. 2024

  
• Potential treatment option of rivaroxaban for breastfeeding women: A case series.

  Yugo Yamashita; Daiki Hira; Makiko Morita; Yurie Katsube; Masahito Takakura; Hiroko Tomotaki; Seiichi Tomotaki; Wei Xiong; Hiroki Shiomi; Takahiro Horie; Satoshi Ueshima; Tomoyuki Mizuno; Tomohiro Terada; Koh Ono

  Thrombosis research, 05 Apr. 2024

  
• Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis.

  Sawa Miyagawa; Takahiro Horie; Tomohiro Nishino; Satoshi Koyama; Toshimitsu Watanabe; Osamu Baba; Tomohiro Yamasaki; Naoya Sowa; Chiharu Otani; Kazuki Matsushita; Hidenori Kojima; Masahiro Kimura; Yasuhiro Nakashima; Satoshi Obika; Yuuya Kasahara; Jun Kotera; Kozo Oka; Ryo Fujita; Takashi Sasaki; Akihiro Takemiya; Koji Hasegawa; Takeshi Kimura; Koh Ono

  Life science alliance, Aug. 2023

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• Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways

  Tomohiro Yamasaki; Takahiro Horie; Satoshi Koyama; Tetsushi Nakao; Osamu Baba; Masahiro Kimura; Naoya Sowa; Kazuhisa Sakamoto; Kazuhiro Yamazaki; Satoshi Obika; Yuuya Kasahara; Jun Kotera; Kozo Oka; Ryo Fujita; Takashi Sasaki; Akihiro Takemiya; Koji Hasegawa; Kenji Minatoya; Takeshi Kimura; Koh Ono

  Scientific Reports, Dec. 2022

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• Overview of the 84th Annual Scientific Meeting of the Japanese Circulation Society - Change Practice!

  Koh Ono; Satoshi Shizuta; Erika Yamamoto; Naritatsu Saito; Neiko Ozasa; Takao Kato; Eri Kato; Takahiro Horie; Junichi Tazaki; Hiroki Shiomi; Shin Watanabe; Hirotoshi Watanabe; Yugo Yamashita; Yusuke Yoshikawa; Hideyuki Kinoshita; Takeru Makiyama; Yoshinori Yoshida; Noboru Ashida; Yasuaki Nakagawa; Yasuhiro Nakashima; Osamu Baba; Hirohiko Kohjitani; Masahiro Kimura; Hideaki Inazumi; Takashi Yoshizawa; Akihiro Komasa; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 25 Feb. 2021

  
• microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.

  Takahiro Horie; Tetsushi Nakao; Yui Miyasaka; Tomohiro Nishino; Shigenobu Matsumura; Fumiko Nakazeki; Yuya Ide; Masahiro Kimura; Shuhei Tsuji; Randolph Ruiz Rodriguez; Toshimitsu Watanabe; Tomohiro Yamasaki; Sijia Xu; Chiharu Otani; Sawa Miyagawa; Kazuki Matsushita; Naoya Sowa; Aoi Omori; Jin Tanaka; Chika Nishimura; Masataka Nishiga; Yasuhide Kuwabara; Osamu Baba; Shin Watanabe; Hitoo Nishi; Yasuhiro Nakashima; Marina R Picciotto; Haruhisa Inoue; Dai Watanabe; Kazuhiro Nakamura; Tsutomu Sasaki; Takeshi Kimura; Koh Ono

  Nature communications, 16 Feb. 2021

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• Functional non-coding RNAs in vascular diseases.

  Koh Ono; Takahiro Horie; Osamu Baba; Masahiro Kimura; Shuhei Tsuji; Randolph Ruiz Rodriguez; Sawa Miyagawa; Takeshi Kimura

  The FEBS journal, 19 Dec. 2020

  
• Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload.

  Yasuhide Kuwabara; Shuhei Tsuji; Masataka Nishiga; Masayasu Izuhara; Shinji Ito; Kazuya Nagao; Takahiro Horie; Shin Watanabe; Satoshi Koyama; Hisanori Kiryu; Yasuhiro Nakashima; Osamu Baba; Tetsushi Nakao; Tomohiro Nishino; Naoya Sowa; Yui Miyasaka; Takeshi Hatani; Yuya Ide; Fumiko Nakazeki; Masahiro Kimura; Yoshinori Yoshida; Tsukasa Inada; Takeshi Kimura; Koh Ono

  Communications biology, 13 Aug. 2020

  
• 髄芽腫の発生と発育におけるmi-R33の役割

  峰晴 陽平; 松井 恭澄; 森本 貴昭; 尾市 雄輝; 鎌田 貴彦; 丹治 正大; 中尾 哲史; 堀江 貴裕; 尾野 亘; 荒川 芳輝

  Brain Tumor Pathology, Aug. 2020

  
• Effects of Metformin on Left Ventricular Size and Function in Hypertensive Patients with Type 2 Diabetes Mellitus: Results of a Randomized, Controlled, Multicenter, Phase IV Trial.

  Koh Ono; Hiromichi Wada; Noriko Satoh-Asahara; Hitoki Inoue; Keita Uehara; Junichi Funada; Atsushi Ogo; Takahiro Horie; Masatoshi Fujita; Akira Shimatsu; Koji Hasegawa

  American journal of cardiovascular drugs : drugs, devices, and other interventions, Jun. 2020, Peer-reviewed

  
• Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity.

  Masahiro Kimura; Takahiro Horie; Osamu Baba; Yuya Ide; Shuhei Tsuji; Randolph Ruiz Rodriguez; Toshimitsu Watanabe; Tomohiro Yamasaki; Chiharu Otani; Sijia Xu; Yui Miyasaka; Yasuhiro Nakashima; Takeshi Kimura; Koh Ono

  EMBO reports, 03 Apr. 2020, Peer-reviewed

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• Utility of collagen-derived peptides as markers of organ injury in patients with acute heart failure.

  Kazuya Nagao; Akinori Tamura; Yukihito Sato; Reo Hata; Yuichi Kawase; Kazushige Kadota; Takahiro Horie; Naoya Sowa; Masataka Nishiga; Koh Ono; Tsukasa Inada; Masaru Tanaka

  Open heart, 2020

  
• Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.

  Yuya Ide; Takahiro Horie; Naritatsu Saito; Shin Watanabe; Chiharu Otani; Yui Miyasaka; Yasuhide Kuwabara; Tomohiro Nishino; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Fumiko Nakazeki; Satoshi Koyama; Masahiro Kimura; Shuhei Tsuji; Randolph Ruiz Rodriguez; Sijia Xu; Tomohiro Yamasaki; Toshimitsu Watanabe; Masamichi Yamamoto; Motoko Yanagita; Takeshi Kimura; Akira Kakizuka; Koh Ono

  JACC. Basic to translational science, Oct. 2019, Peer-reviewed

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• Identification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice.

  Satoshi Koyama; Takahiro Horie; Tomohiro Nishino; Osamu Baba; Naoya Sowa; Yui Miyasaka; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Fumiko Nakazeki; Yuya Ide; Masahiro Kimura; Shuhei Tsuji; Randolph Ruiz Rodriguez; Sijia Xu; Tomohiro Yamasaki; Chiharu Otani; Toshimitsu Watanabe; Tomoyuki Nakamura; Koji Hasegawa; Takeshi Kimura; Koh Ono

  Journal of the American Heart Association, 02 Jul. 2019, Peer-reviewed

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• アテローム性動脈硬化形成におけるmicroRNA-33aおよび-33bが与える影響の違いについての検討

  宮阪 由依; 小山 智志; 堀江 貴裕; 藤井 康友; 木村 剛; 尾野 亘

  日本動脈硬化学会総会プログラム・抄録集, Jul. 2019

  
• アテローム性動脈硬化形成におけるmicroRNA-33aおよび-33bが与える影響の違いについての検討

  宮阪 由依; 小山 智史; 堀江 貴裕; 藤井 康友; 木村 剛; 尾野 亘

  日本臨床分子医学会学術総会プログラム・抄録集, Apr. 2019

  
• MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.

  Fumiko Nakazeki; Itaru Tsuge; Takahiro Horie; Keiko Imamura; Kayoko Tsukita; Akitsu Hotta; Osamu Baba; Yasuhide Kuwabara; Tomohiro Nishino; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Shuhei Tsuji; Motoko Naitoh; Shigehiko Suzuki; Yuishin Izumi; Toshitaka Kawarai; Ryuji Kaji; Takeshi Kimura; Haruhisa Inoue; Koh Ono

  Clinical science (London, England : 1979), 28 Feb. 2019, Peer-reviewed

  
• is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.

  Fumiko Nakazeki; Itaru Tsuge; Takahiro Horie; Keiko Imamura; Kayoko Tsukita; Akitsu Hotta; Osamu Baba; Yasuhide Kuwabara; Tomohiro Nishino; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Shuhei Tsuji; Motoko Naitoh; Shigehiko Suzuki; Yuishin Izumi; Toshitaka Kawarai; Ryuji Kaji; Takeshi Kimura; Haruhisa Inoue; Koh Ono

  Clinical Science, 22 Feb. 2019, Peer-reviewed

  
• Circulating markers of collagen types I, III, and IV in patients with dilated cardiomyopathy: relationships with myocardial collagen expression.

  Kazuya Nagao; Tsukasa Inada; Akinori Tamura; Kenji Kajitani; Kiyotaka Shimamura; Hiroshi Yukawa; Kenji Aida; Naoya Sowa; Masataka Nishiga; Takahiro Horie; Toshinori Makita; Koh Ono; Masaru Tanaka

  ESC heart failure, Dec. 2018, Peer-reviewed

  
• Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction.

  Daihiko Hakuno; Masahiro Kimura; Shinji Ito; Junko Satoh; Yasuhiro Nakashima; Takahiro Horie; Yasuhide Kuwabara; Masataka Nishiga; Yuya Ide; Osamu Baba; Hitoo Nishi; Tetsushi Nakao; Tomohiro Nishino; Fumiko Nakazeki; Satoshi Koyama; Ritsuko Hanada; Ruiz R Randolph; Jin Endo; Takeshi Kimura; Koh Ono

  Scientific reports, 13 Nov. 2018, Peer-reviewed

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• SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo.

  Tomohiro Nishino; Takahiro Horie; Osamu Baba; Naoya Sowa; Ritsuko Hanada; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Hitoo Nishi; Yasuhiro Nakashima; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Manabu Nagata; Kazumichi Yoshida; Yasushi Takagi; Tomoyuki Nakamura; Koji Hasegawa; Susumu Miyamoto; Takeshi Kimura; Koh Ono

  Arteriosclerosis, thrombosis, and vascular biology, Oct. 2018, Peer-reviewed

  
• MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6Chigh Monocytes through Dual Pathways.

  Osamu Baba; Takahiro Horie; Tetsushi Nakao; Daihiko Hakuno; Yasuhiro Nakashima; Hitoo Nishi; Yasuhide Kuwabara; Masataka Nishiga; Tomohiro Nishino; Yuya Ide; Fumiko Nakazeki; Satoshi Koyama; Masahiro Kimura; Ritsuko Hanada; Masahiro Kawahara; Takeshi Kimura; Koh Ono

  Molecular and cellular biology, 15 Jul. 2018, Peer-reviewed

  
• Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo.

  Fumiko Nakazeki; Masataka Nishiga; Takahiro Horie; Hitoo Nishi; Yasuhiro Nakashima; Osamu Baba; Yasuhide Kuwabara; Tomohiro Nishino; Tetsushi Nakao; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Shuhei Tsuji; Naoya Sowa; Shigeo Yoshida; Simon J Conway; Motoko Yanagita; Takeshi Kimura; Koh Ono

  Scientific reports, 04 Jun. 2018, Peer-reviewed

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• Long Non-Coding RNAs as Key Regulators of Cardiovascular Diseases.

  Koh Ono; Yasuhide Kuwabara; Takahiro Horie; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 25 Apr. 2018, Peer-reviewed

  
• Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy.

  Mamoru Hayano; Takeru Makiyama; Tsukasa Kamakura; Hiroshi Watanabe; Kenichi Sasaki; Shunsuke Funakoshi; Yimin Wuriyanghai; Suguru Nishiuchi; Takeshi Harita; Yuta Yamamoto; Hirohiko Kohjitani; Sayako Hirose; Fumika Yokoi; Jiarong Chen; Osamu Baba; Takahiro Horie; Kazuhisa Chonabayashi; Seiko Ohno; Futoshi Toyoda; Yoshinori Yoshida; Koh Ono; Minoru Horie; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 24 Nov. 2017, Peer-reviewed

  
• Human iPSC-Derived Myocyte Mmodel of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting From Enhanced Protein Degradation

  Hayano Mamoru; Makiyama Takeru; Kamakura Tsukasa; Watanabe Hiroshi; Sasaki Kenichi; Funakoshi Shunsuke; Wuriyanghai Yimin; Nishiuchi Suguru; Harita Takeshi; Yamamoto Yuta; Kohjitani Hirohiko; Hirose Sayako; Yokoi Fumika; Chen Jiarong; Baba Osamu; Horie Takahiro; Chonabayashi Kazuhisa; Ohno Seiko; Toyoda Futoshi; Yoshida Yoshinori; Ono Koh; Horie Minoru; Kimura Takeshi

  CIRCULATION, 14 Nov. 2017, Peer-reviewed

  
• Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways.

  Tetsushi Nakao; Takahiro Horie; Osamu Baba; Masataka Nishiga; Tomohiro Nishino; Masayasu Izuhara; Yasuhide Kuwabara; Hitoo Nishi; Shunsuke Usami; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Naoya Sowa; Satoko Ohno; Hiroki Aoki; Koji Hasegawa; Kazuhisa Sakamoto; Kenji Minatoya; Takeshi Kimura; Koh Ono

  Arteriosclerosis, thrombosis, and vascular biology, Nov. 2017, Peer-reviewed

  
• Dynamic changes of serum microRNA-122-5p through therapeutic courses indicates amelioration of acute liver injury accompanied by acute cardiac decompensation.

  Satoshi Koyama; Takashi Kuragaichi; Yukihito Sato; Yasuhide Kuwabara; Shunsuke Usami; Takahiro Horie; Osamu Baba; Daihiko Hakuno; Yasuhiro Nakashima; Tomohiro Nishino; Masataka Nishiga; Tetsushi Nakao; Hidenori Arai; Takeshi Kimura; Koh Ono

  ESC heart failure, May 2017, Peer-reviewed

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• MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.

  Masataka Nishiga; Takahiro Horie; Yasuhide Kuwabara; Kazuya Nagao; Osamu Baba; Tetsushi Nakao; Tomohiro Nishino; Daihiko Hakuno; Yasuhiro Nakashima; Hitoo Nishi; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Ritsuko Hanada; Tomoyuki Nakamura; Tsukasa Inada; Koji Hasegawa; Simon J Conway; Toru Kita; Takeshi Kimura; Koh Ono

  Circulation research, 03 Mar. 2017, Peer-reviewed

  
• Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model.

  Masayasu Izuhara; Yasuhide Kuwabara; Naritatsu Saito; Erika Yamamoto; Daihiko Hakuno; Yasuhiro Nakashima; Takahiro Horie; Osamu Baba; Masataka Nishiga; Tetsushi Nakao; Tomohiro Nishino; Fumiko Nakazeki; Yuya Ide; Masahiro Kimura; Takeshi Kimura; Koh Ono

  PloS one, 2017, Peer-reviewed

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• MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.

  Yuji Eso; Atsushi Takai; Tomonori Matsumoto; Tadashi Inuzuka; Takahiro Horie; Koh Ono; Shinji Uemoto; Kyeryoung Lee; Winfried Edelmann; Tsutomu Chiba; Hiroyuki Marusawa

  Cancer research, 01 Aug. 2016, Peer-reviewed

  
• 開心術をうけた心血管患者血清と心嚢水におけるマイクロRNA423‐5pの発現

  宇佐美俊輔; 宮本昌一; 桑原康秀; 堀江貴裕; 馬場理; 伯野大彦; 中島康弘; 西賀雅隆; 出原正康; 中尾哲史; 西野共達; 井手裕也; 中関典子; 木村昌弘; 花田律子; 植山浩二; 木村剛; 尾野亘

  血管, 31 Jan. 2016

  
• Emerging Novel Biomarkers for Arteriosclerosis Obliterans.

  Takahiro Horie; Takeshi Kimura; Koh Ono

  Journal of atherosclerosis and thrombosis, 2016, Peer-reviewed

  
• microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain.

  Jaekwang Kim; Hyejin Yoon; Takahiro Horie; Jack M Burchett; Jessica L Restivo; Noemi Rotllan; Cristina M Ramírez; Philip B Verghese; Masafumi Ihara; Hyang-Sook Hoe; Christine Esau; Carlos Fernández-Hernando; David M Holtzman; John R Cirrito; Koh Ono; Jungsu Kim

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 04 Nov. 2015, Peer-reviewed

  
• High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.

  Masayasu Izuhara; Koh Ono; Hiroki Shiomi; Takeshi Morimoto; Yutaka Furukawa; Yoshihisa Nakagawa; Satoshi Shizuta; Tomohisa Tada; Junichi Tazaki; Takahiro Horie; Yasuhide Kuwabara; Osamu Baba; Tomohiro Nishino; Toru Kita; Takeshi Kimura

  Atherosclerosis, Oct. 2015, Peer-reviewed

  
• Serum HDL-C Decreases in MicroRNA-33b Knock-in Mice for an Intron of Sterol Regulatory Element-binding Factor 1 (Srebf1)

  Horie Takahiro; Nishino Tomohiro; Kuwabara Yasuhide; Baba Osamu; Kimura Takeshi; Ono Koh

  CIRCULATION RESEARCH, 17 Jul. 2015, Peer-reviewed

  
• Srebf1のイントロンにmicroRNA‐33bをノックインしたマウスはHDLコレステロールの減少を示す

  堀江貴裕; 西野共達; 馬場理; 桑原康秀; 中尾哲史; 西賀雅隆; 宇佐美俊輔; 出原正康; 島野仁; 横出正之; 北徹; 木村剛; 尾野亘

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 25 Jun. 2015

  
• イントロンに存在するmicroRNA‐33aおよび33bとそのホスト遺伝子SREBP2およびSREBP1間の脂質代謝クロストークの解明

  堀江貴裕; 尾野亘; 木村剛; 横出正之

  医科学応用研究財団研究報告(CD-ROM), Feb. 2015

  
• MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.

  Yasuhide Kuwabara; Takahiro Horie; Osamu Baba; Shin Watanabe; Masataka Nishiga; Shunsuke Usami; Masayasu Izuhara; Tetsushi Nakao; Tomohiro Nishino; Kinya Otsu; Toru Kita; Takeshi Kimura; Koh Ono

  Circulation research, 16 Jan. 2015, Peer-reviewed

  
• SREBP1のイントロンに存在するmiR‐33bはHDLコレステロールを減少させる

  堀江貴裕; 西野共達; 馬場理; 桑原康秀; 中尾哲史; 西賀雅隆; 宇佐美俊輔; 出原正康; 中関典子; 井手裕也; 小山智史; 曽和尚也; 矢作直也; 島野仁; 横出正之; 北徹; 木村剛; 尾野亘

  日本血管生物医学会学術集会プログラム・抄録集, 2015

  
• マウス大動脈縮窄モデルにより増加するlincRNAはマウス心筋細胞において心肥大を誘導する

  桑原康秀; 桑原康秀; 堀江貴裕; 馬場理; 出原正康; 宇佐美俊輔; 西賀雅隆; 西野共達; 北徹; 木村剛; 尾野亘

  日本心不全学会学術集会プログラム・抄録集, 2015

  
• SREBPのイントロン性マイクロRNAの生体における脂質代謝機構の包括的解明

  堀江貴裕; 尾野亘; 木村剛; 横出正之

  先進医薬研究振興財団 2014年度 研究成果報告集, 2015

  
• MicroRNA-33a/b in lipid metabolism – novel “thrifty” models.

  Koh Ono; Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Masayuki Yokode; Toru Kita; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 2015, Peer-reviewed

  
• MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism.

  Koh Ono; Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Takeshi Kimura

  International heart journal, 2015, Peer-reviewed

  
• Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery.

  Shoichi Miyamoto; Shunsuke Usami; Yasuhide Kuwabara; Takahiro Horie; Osamu Baba; Daihiko Hakuno; Yasuhiro Nakashima; Masataka Nishiga; Masayasu Izuhara; Tetsushi Nakao; Tomohiro Nishino; Yuya Ide; Fumiko Nakazeki; Jun Wang; Koji Ueyama; Takeshi Kimura; Koh Ono

  PloS one, 2015, Peer-reviewed

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• microRNA‐33の動脈硬化・脂質制御における役割

  尾野亘; 堀江貴裕; 桑原康秀; 馬場理; 西野共達; 久米典昭; 横出正之; 北徹, 木村剛

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 25 Jun. 2014

  
• マイクロRNA‐33による脂質代謝制御機構の解明

  堀江貴裕; 桑原康秀; 馬場理; 西野共達; 中尾哲史; 西賀雅隆; 宇佐美俊輔; 出原正康; 矢作直也; 島野仁; 横出正之; 北徹; 木村剛; 尾野亘

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 25 Jun. 2014

  
• MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.

  Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Shunsuke Usami; Masayasu Izuhara; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Naoya Sowa; Naoya Yahagi; Hitoshi Shimano; Tomoyuki Nakamura; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  Scientific reports, 16 Jun. 2014, Peer-reviewed

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• Srebf1のイントロンにmicroRNA‐33bをノックインしたマウスはHDLコレステロールの減少を示す

  堀江貴裕; 西野共達; 馬場理; 桑原康秀; 中尾哲史; 西賀雅隆; 宇佐美俊輔; 出原正康; 井手裕也; 中関典子; 小山智史; 曽和尚也; 木村剛; 尾野亘

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• 飽和脂肪酸により誘導されるmicroRNA‐451は,糖尿病性心筋症の増悪因子である

  桑原康秀; 堀江貴裕; 馬場理; 出原正康; 宇佐美俊輔; 中尾哲史; 西賀雅隆; 西野共達; 井手裕也; 中関典子; 小山智史; 木村剛; 尾野亘

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• マイクロRNA‐33は,生体内においてSREBP‐1を介して脂肪酸代謝を制御する

  西野共達; 堀江貴裕; 馬場理; 桑原康秀; 中尾哲史; 西賀雅隆; 宇佐美俊輔; 出原正康; 中関典子; 井手裕也; 小山智史; 曽和尚也; 木村剛; 尾野亘

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• MicroRNAs and Lipoprotein Metabolism.

  Takahiro Horie; Osamu Baba; Yasuhide Kuwabara; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  Journal of atherosclerosis and thrombosis, 2014, Peer-reviewed

  
• Cardiac-specific inhibition of kinase activity in calcium/calmodulin-dependent protein kinase kinase-β leads to accelerated left ventricular remodeling and heart failure after transverse aortic constriction in mice.

  Shin Watanabe; Takahiro Horie; Kazuya Nagao; Yasuhide Kuwabara; Osamu Baba; Hitoo Nishi; Naoya Sowa; Michiko Narazaki; Tetsuya Matsuda; Genzou Takemura; Hiromichi Wada; Koji Hasegawa; Takeshi Kimura; Koh Ono

  PloS one, 2014, Peer-reviewed

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• LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Ventricular Cardiomyocytes

  Kuwabara Yasuhide; Izuhara Masayasu; Horie Takahiro; Watanabe Shin; Baba Osamu; Usami Shunsuke; Nakao Tetsushi; Nishiga Masataka; Nishino Tomohiro; Kita Toru; Kimura Takeshi; Ono Koh

  CIRCULATION, 26 Nov. 2013, Peer-reviewed

  
• Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts.

  Yodo Tamaki; Yoshitaka Iwanaga; Shinichiro Niizuma; Tsuneaki Kawashima; Takao Kato; Yasutaka Inuzuka; Takahiro Horie; Hanako Morooka; Toru Takase; Yasumitsu Akahashi; Kazuhiro Kobuke; Koh Ono; Tetsuo Shioi; Søren P Sheikh; Noona Ambartsumian; Eugene Lukanidin; Taka-Aki Koshimizu; Shunichi Miyazaki; Takeshi Kimura

  Journal of molecular and cellular cardiology, Apr. 2013, Peer-reviewed

  
• マイクロRNA制御による動脈硬化治療の探索的研究

  堀江貴裕; 馬場理; 桑原康秀; 久米典昭; 横出正之; 北徹; 木村剛; 尾野亘

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 2013

  
• miRNAと動脈硬化・心不全

  尾野亘; 堀江貴裕; 馬場理; 桑原康秀; 北徹, 木村剛

  日本循環薬理学会口演要旨集, 2013

  
• 循環器疾患におけるバイオマーカーとしての血清中microRNA

  桑原康秀; ガーボルバジョー; 堀江貴裕; 馬場理; 出原正康; 宇佐美俊輔; 中尾哲史; 西賀雅隆; 西野共達; 北徹; 和田啓道; 長谷川浩二; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.

  Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Shunsuke Usami; Masayasu Izuhara; Naoya Sowa; Naoya Yahagi; Hitoshi Shimano; Shigenobu Matsumura; Kazuo Inoue; Hiroyuki Marusawa; Tomoyuki Nakamura; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  Nature communications, 2013, Peer-reviewed

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• MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.

  Takahiro Horie; Osamu Baba; Yasuhide Kuwabara; Yoshimasa Chujo; Shin Watanabe; Minako Kinoshita; Masahito Horiguchi; Tomoyuki Nakamura; Kazuhisa Chonabayashi; Masakatsu Hishizawa; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  Journal of the American Heart Association, Dec. 2012, Peer-reviewed

  
• MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene.

  Naoya Sowa; Takahiro Horie; Yasuhide Kuwabara; Osamu Baba; Shin Watanabe; Hitoo Nishi; Minako Kinoshita; Rieko Takanabe-Mori; Hiromichi Wada; Akira Shimatsu; Koji Hasegawa; Takeshi Kimura; Koh Ono

  Journal of cellular biochemistry, Nov. 2012, Peer-reviewed

  
• 動脈硬化進展におけるマイクロRNA‐33の働き

  尾野亘; 堀江貴裕; 馬場理; 久米典昭; 横出正之; 北徹, 木村剛

  日本心臓病学会誌, 06 Aug. 2012

  
• microRNA‐33の動脈硬化形成における役割の検討

  尾野亘; 堀江貴裕; 馬場理; 久米典昭; 横出正之; 北徹, 木村剛

  日本動脈硬化学会総会・学術集会プログラム・抄録集(CD-ROM), 05 Jul. 2012

  
• マイクロRNA‐33は動脈硬化形成を制御する

  堀江貴裕; 馬場理; 尾野亘; 渡辺真; 西仁勇; 木下美菜子; 桑原康秀; 中條克真; 横出正之; 木村剛

  日本内科学会雑誌, 20 Feb. 2012

  
• Roles of microRNAs and myocardial cell differentiation.

  Tomohide Takaya; Hitoo Nishi; Takahiro Horie; Koh Ono; Koji Hasegawa

  Progress in molecular biology and translational science, 2012, Peer-reviewed

  
• ポストシークエンス時代の心脈管ゲノミクス 1 Non‐coding RNAと心血管疾患

  尾野亘; 堀江貴裕; 西仁勇; 木下美菜子; 桑原康秀; 馬場理; 木村剛

  血管, 11 Oct. 2011

  
• マイクロRNAと循環器疾患 4)コレステロールホメオスタシスとマイクロRNA

  堀江貴裕; 尾野亘; 横出正之; 木村剛

  血管医学, 31 Aug. 2011

  
• Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage.

  Yasuhide Kuwabara; Koh Ono; Takahiro Horie; Hitoo Nishi; Kazuya Nagao; Minako Kinoshita; Shin Watanabe; Osamu Baba; Yoji Kojima; Satoshi Shizuta; Masao Imai; Toshihiro Tamura; Toru Kita; Takeshi Kimura

  Circulation. Cardiovascular genetics, 01 Aug. 2011, Peer-reviewed

  
• MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1 in neonatal rat ventricular myocytes.

  Hitoo Nishi; Koh Ono; Takahiro Horie; Kazuya Nagao; Minako Kinoshita; Yasuhide Kuwabara; Shin Watanabe; Tomohide Takaya; Yodo Tamaki; Rieko Takanabe-Mori; Hiromichi Wada; Koji Hasegawa; Yoshitaka Iwanaga; Teruhisa Kawamura; Toru Kita; Takeshi Kimura

  Molecular and cellular biology, Feb. 2011, Peer-reviewed

  
• Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects.

  Hiromichi Wada; Shuichi Ura; Shuji Kitaoka; Noriko Satoh-Asahara; Takahiro Horie; Koh Ono; Tomohide Takaya; Rieko Takanabe-Mori; Masaharu Akao; Mitsuru Abe; Tatsuya Morimoto; Toshinori Murayama; Masayuki Yokode; Masatoshi Fujita; Akira Shimatsu; Koji Hasegawa

  PloS one, 2011, Peer-reviewed

  
• MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo.

  Takahiro Horie; Koh Ono; Masahito Horiguchi; Hitoo Nishi; Tomoyuki Nakamura; Kazuya Nagao; Minako Kinoshita; Yasuhide Kuwabara; Hiroyuki Marusawa; Yoshitaka Iwanaga; Koji Hasegawa; Masayuki Yokode; Takeshi Kimura; Toru Kita

  Proceedings of the National Academy of Sciences of the United States of America, 05 Oct. 2010, Peer-reviewed

  
• Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5.

  Minako Kinoshita; Koh Ono; Takahiro Horie; Kazuya Nagao; Hitoo Nishi; Yasuhide Kuwabara; Rieko Takanabe-Mori; Koji Hasegawa; Toru Kita; Takeshi Kimura

  Molecular endocrinology (Baltimore, Md.), Oct. 2010, Peer-reviewed

  
• Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway.

  Takahiro Horie; Koh Ono; Hitoo Nishi; Kazuya Nagao; Minako Kinoshita; Shin Watanabe; Yasuhide Kuwabara; Yasuhiro Nakashima; Rieko Takanabe-Mori; Eiichiro Nishi; Koji Hasegawa; Toru Kita; Takeshi Kimura

  Cardiovascular research, 01 Sep. 2010, Peer-reviewed

  
• Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice.

  Rieko Takanabe-Mori; Koh Ono; Naoya Sowa; Hiromichi Wada; Tomohide Takaya; Takahiro Horie; Noriko Satoh-Asahara; Akira Shimatsu; Masatoshi Fujita; Tatsuya Sawamura; Koji Hasegawa

  Biochemical and biophysical research communications, 30 Jul. 2010, Peer-reviewed

  
• Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress.

  Kazuya Nagao; Koh Ono; Yoshitaka Iwanaga; Yodo Tamaki; Yoji Kojima; Takahiro Horie; Hitoo Nishi; Minako Kinoshita; Yasuhide Kuwabara; Koji Hasegawa; Toru Kita; Takeshi Kimura

  Journal of molecular and cellular cardiology, Jun. 2010, Peer-reviewed

  
• MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes.

  Hitoo Nishi; Koh Ono; Yoshitaka Iwanaga; Takahiro Horie; Kazuya Nagao; Genzou Takemura; Minako Kinoshita; Yasuhide Kuwabara; Rieko Takanabe Mori; Koji Hasegawa; Toru Kita; Takeshi Kimura

  The Journal of biological chemistry, 12 Feb. 2010, Peer-reviewed

  
• MicroRNA-33 encoded by an intron of Srebp2 regulates HDL in vivo Proc Natl Acad Sci U S A. 2010;107:17321-6.

  Horie T; Ono K; Horiguchi M; Nishi H; Nakamura T; Nagao K; Kinoshita M; Kuwabara Y; Marusawa H; Iwanaga Y; Hasegawa K; Yokode M; Kimura T; Kita T

  2010, Peer-reviewed

  
• MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes.

  Takahiro Horie; Koh Ono; Hitoo Nishi; Yoshitaka Iwanaga; Kazuya Nagao; Minako Kinoshita; Yasuhide Kuwabara; Rieko Takanabe; Koji Hasegawa; Toru Kita; Takeshi Kimura

  Biochemical and biophysical research communications, 13 Nov. 2009, Peer-reviewed

  
• Let‐7,microRNA‐98は心筋細胞においてGLUT4の発現を低下させインスリン抵抗性を惹起する

  曽和尚也; 尾野亘; 堀江貴裕; 西仁勇; 長央和也; 木下美菜子; 森利依子; 阿部由希子; 北徹; 島津章; 長谷川浩二

  糖尿病, 25 Apr. 2009

  
• Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet.

  Rieko Takanabe; Koh Ono; Yukiko Abe; Tomohide Takaya; Takahiro Horie; Hiromichi Wada; Toru Kita; Noriko Satoh; Akira Shimatsu; Koji Hasegawa

  Biochemical and biophysical research communications, 28 Nov. 2008, Peer-reviewed

  
• Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes.

  Rumi Maruyama; Kazuko Goto; Genzou Takemura; Koh Ono; Kazuya Nagao; Takahiro Horie; Akiko Tsujimoto; Hiromitsu Kanamori; Shusaku Miyata; Hiroaki Ushikoshi; Kenshi Nagashima; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara

  American journal of physiology. Heart and circulatory physiology, Oct. 2008, Peer-reviewed

  
• マウス脂肪組織におけるmicroRNA‐143の発現は肥満と共に増加する

  高鍋利依子; 尾野亘; 高谷智英; 堀江貴裕; 和田啓道; 北徹; 島津章; 長谷川浩二

  日本内分泌学会雑誌, 20 Sep. 2008

  
• micro RNAをターゲットとした肥満に伴う心血管系疾患治療法の開発

  尾野亘; 堀江貴裕; 西仁勇; 長央和也; 木下美菜子; 北徹

  Ther Res, 20 Aug. 2008

  
• Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes.

  Takahiro Horie; Koh Ono; Kazuya Nagao; Hitoo Nishi; Minako Kinoshita; Teruhisa Kawamura; Hiromichi Wada; Akira Shimatsu; Toru Kita; Koji Hasegawa

  Journal of cellular physiology, Jun. 2008, Peer-reviewed

  
• TG-interacting factor is required for the differentiation of preadipocytes.

  Takahiro Horie; Koh Ono; Minako Kinoshita; Hitoo Nishi; Kazuya Nagao; Teruhisa Kawamura; Yukiko Abe; Hiromichi Wada; Akira Shimatsu; Toru Kita; Koji Hasegawa

  Journal of lipid research, Jun. 2008, Peer-reviewed

  
• 21世紀フォーラム心血管病とリスクファクター 5th 脂肪細胞由来セロトニンを標的としたメタボリックシンドローム治療法の開発

  尾野亘; 堀江貴裕; 木下美菜子; 長央和也; 西仁勇; 森利依子; 長谷川浩二; 北徹

  血圧, 01 Sep. 2007

  
• インスリンによるTG‐interacting factorの活性化は前駆脂肪細胞の分化に必要である

  堀江貴裕; 尾野亘; 阿部由希子; 川村晃久; 島津明; 長谷川浩二; 北徹

  糖尿病, 30 Jun. 2007

  
• 耐糖能障害の病態解明―GLUT4トランスロケーション機構の解明―

  尾野亘; 堀江貴裕; 北徹

  代謝異常治療研究基金研究業績集, 2007

  
• インスリンによるTG‐interacting Factor(TGIF)の活性化は前駆脂肪細胞の分化に必要である

  堀江貴裕; 尾野亘; 阿部由希子; 川村晃久; 島津章; 北徹; 長谷川浩二

  糖尿病, 25 Apr. 2006

  
• Serum cardiac troponin T in cardiac amyloidosis: serial observations in five patients.

  Takao Kato; Yukihito Sato; Kazuya Nagao; Takahiro Horie; Kazuaki Kataoka; Tadashi Miyamoto; Yoshiki Takatsu

  The Tohoku journal of experimental medicine, Feb. 2006, Peer-reviewed

  
• A case of intravascular ultrasound catheter entrapment after radius stent implantation

  Kato T; Kataoka K; Hoshino K; Matsuoka T; Nagao K; Horie T; Miyamoto T; Sato Y; Takatsu Y

  Japanese Journal of Interventional Cardiology, 2005, Peer-reviewed

  
• A Long Dialysis Period has a Strong Impact on Restenosis after Percutaneous Coronary Intervention (PCI) in Chronic Hemodialysis Patients

  Y. Nakashima; K. Kataoka; R. Taniguchi; T. Miyamoto; K. Hoshino-Nagai; T. Makiyama; T. Kato; T. Horie; K. Nagao; Y. Takatsu

  Japanese Journal of Interventional Cardiology, 2004, Peer-reviewed

  
• Vessel Size, Not Stent Length, Is the Most Important Predictor of Restenosis after NIR Stent Implantation

  T. Miyamoto; K. Nagai; Y. Sato; T. Makiyama; K. Nagao; Y. Nakashima; T. Kato; T. Horie; R. Taniguchi; T. Yamada; K. Kataoka; Y. Takatsu

  Japanese Journal of Interventional Cardiology, 2004, Peer-reviewed

  

Misc.

• microRNA-33bの特異的抑制は炎症反応経路を介して腹部大動脈瘤形成を抑制する

  山崎智弘; 堀江貴裕; 小山智史; 中尾哲史; 馬場理; 曽和尚也; 小比賀聡; 小比賀聡; 笠原勇矢; 笠原勇矢; 小寺淳; 岡幸蔵; 藤田領; 佐々木隆史; 竹宮明広; 木村剛; 尾野亘

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 2022

  
• microRNA-33bの特異的抑制による腹部大動脈瘤形成抑制効果の検討

  山崎智弘; 堀江貴裕; 小山智; 中尾哲史; 馬場理; 曽和尚也; 小比賀聡; 小比賀聡; 笠原勇矢; 小寺淳; 岡幸蔵; 藤田領; 佐々木隆史; 竹宮明広; 木村剛; 尾野亘

  日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 2021

  
• CaMKK beta contributes to energy supply in adaptive phase of pressure-overload-induced heart failure

  S. Watanabe; K. Ono; T. Horie; H. Nishi; Y. Kuwabara; O. Baba; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2011

  
• OE-166 Upregulation of MicroRNA Targeting Retinoid X Receptor A Contributes to Development of Cardiac Hypertrophy(Molecular biology, myocardium (M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Nishi Hitoo; Ono Koh; Horie Takahiro; Kinoshita Minako; Nagao Kazuya; Iwanaga Yoshitaka; Hasegawa Koji; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• OE-233 MicroRNA-133 Regulates the Expression of GLUT4 by Targeting KLF15 and is Involved in Metabolic Control in Cardiac Myocytes(Metabolism/Biochemistry/Energetics(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Horie Takahiro; Ono Koh; Kinoshita Minako; Nishi Hitoo; Nagao Kazuya; Mori Rieko; Iwanaga Yoshitaka; Hasegawa Koji; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• PE-419 Enkephalin is Required for Adipocyte Differentiation and is Involved in Impaired Glucose Tolerance in Rat Model of Type II Diabetes(Diabetes/Obesity/Metabolic syndrome-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Ono Koh; Horie Takahiro; Takanabe Rieko; Kinoshita Minako; Nishi Hitoo; Nagao Kazuya; Kita Toru; Hasegawa Koji

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• PE-409 Functional Cloning of the Genes which Regulates GLUT4 Trafficking in Cardiac Myocytes(Diabetes/Obesity/Metabolic syndrome-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Kinoshita Minako; Ono Koh; Horie Takahiro; Nagao Kazuya; Nishi Hitoo; Hasegawa Koji; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• PE-417 Activation of TG-interacting Factor by Insulin Regulates Adipocyte Differentiation(Diabetes/Obesity/Metabolic syndrome-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Horie Takahiro; Ono Koh; Kita Toru; Hasegawa Koji

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• FRS-024 Up-Regulated Expression of MicroRNA-143 in the Adipose Tissue of High-Fat Diet-Induced Obese Mice(Diabetes/Obesity (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Takanabe Rieko; Ono Koh; Takaya Tomohide; Horie Takahiro; Kita Toru; Shimatsu Akira; Hasegawa Kouji

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• OE-109 Trapping of Genes that Encode Secreted and Transmembrane Proteins in H9C2 cardiomyoblasts(Growth factor/Cytokine-1(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Nagao Kazuya; Ono Koh; Horie Takahiro; Nishi Hitoo; Kinoshita Minako; Hasegawa Koji; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• PE-171 Oxidative Stress Induces GLUT4 Translocation by Dual AMPK Kinase Activation in Cardiac Myocytes(Metabolism/Biochemistry/Energetics-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Horie Takahiro; Ono Koh; Wada Hiromichi; Kita Toru; Hasegawa Koji

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• PE-172 miR-133 Controls GLUT4 Expression by Targeting KLF15 in Cardiomyocytes(Metabolism/Biochemistry/Energetics-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Horie Takahiro; Ono Koh; Nishi Hitoo; Nagao Kazuya; Kinosita Minako; Hasegawa Koji; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• OE-317 MicroRNA-206 Controls Expression of α-and β-Myosin Heavy Chain Genes in Cardiac Myocytes(Molecular biology, myocardium-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Nishi Hitoo; Ono Koh; Horie Takahiro; Kinoshita Minako; Nagao Kazuya; Hasegawa Koji; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• Femoral Endarteritis and Pyogenic Osteomyelitis Associated with Percutaneous Closure Device (The Closer S)

  NAGAO Kazuya; KATAOKA Kazuaki; KATO Takao; HORIE Takahiro; MIYAMOTO Tadashi; MATSUOKA Tatsuhiko; ISODA Kei; KUWABARA Yasuhide; YAMANE Keiichiro; NISHI Kiyoto; SATO Yukihito; TAKATSU Yoshiki

  Japanese journal of interventional cardiology, 10 Apr. 2006

  
• Influence of balloon pressure after Raidus stent deployment on long-term angiographic outcome

  KATAOKA K; Nakashima Yasuhiro; Katoh Takao; Horie Takahiro; Nagao Kazuya; Makiyama Takeru; Hoshino Kouzou; Miyamoto Tadashi; Takatsu Yoshiki

  Cir J, 2004

  
• 冠攣縮性狭心症の診断12年後に冠動脈瘤が生じた一例(第99回日本循環器学会近畿地方会)

  錦織 知穂; 片岡 一明; 松岡 龍彦; 長央 和也; 堀江 貴裕; 加藤 貴雄; 宮本 忠司; 佐藤 幸人; 鷹津 良樹

  Circulation journal : official journal of the Japanese Circulation Society, 20 Oct. 2005

  
• 単独部分肺静脈還流異常症の一例(第99回日本循環器学会近畿地方会)

  西村 麻由; 鷹津 良樹; 佐藤 幸人; 宮本 忠司; 片岡 一明; 堀江 貴裕; 加藤 貴雄; 長央 和也; 松岡 龍彦

  Circulation journal : official journal of the Japanese Circulation Society, 20 Oct. 2005

  
• 心臓細動を伴う初回発症非虚血性左室収縮不全患者の遠隔期心機能の検討(第99回日本循環器学会近畿地方会)

  宮本 忠司; 佐藤 幸人; 松岡 龍彦; 長央 和也; 加藤 貴雄; 堀江 貴裕; 片岡 一明; 鷹津 良樹

  Circulation journal : official journal of the Japanese Circulation Society, 20 Oct. 2005

  
• Cardiac ECM Degradation is Actually Occurring in Patients with Decompensated CHF : Measurement of Serum Carboxyterminal Telopeptide of Type-1 Collagen(Heart Failure, Clinical 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Miyamoto Tadashi; Satoh Yukihito; Matsuoka Tatsuhiko; Nagao Kazuya; Horie Takahiro; Katoh Takao; Kataoka Kazuaki; Takatsu Yoshiki

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

  
• Non-ischemic Ventricular Systolic Dysfunction with Atrial Fibrillation Should Not be Diagnosed as Dilated Cardiomyopathy When Limited to First Onset(Cardiomyopathy, Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Miyamoto Tadashi; Satoh Yukihito; Matsuoka Tatsuhiko; Nagao Kazuya; Horie Takahiro; Katoh Takao; Kataoka Kazuaki; Takatsu Yoshiki

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

  
• 105) ペースメーカー不全を来し閾値の急上昇で発見されたアミロイドーシスの一例(第96回日本循環器学会近畿地方会)

  加藤 貴雄; 宮本 忠司; 長央 和也; 堀江 貴裕; 中島 康弘; 片岡 一明; 鷹津 良樹

  Circulation journal : official journal of the Japanese Circulation Society, 20 Apr. 2004

  
• 92)急速な再狭窄をきたした慢性腎不全透析患者の一例

  中島 康弘; 宮本 忠司; 片岡 一明; 加藤 貴雄; 堀江 貴裕; 長央 和也; 鷹津 良樹

  Circulation journal : official journal of the Japanese Circulation Society, 20 Apr. 2003

  
• 73)上大静脈閉塞を伴ったBudd-Chiari症候群の一例

  堀江 貴裕; 宮本 忠司; 片岡 一明; 中島 康弘; 加藤 貴雄; 長央 和也; 鷹津 良樹

  Circulation journal : official journal of the Japanese Circulation Society, 20 Apr. 2003

  
• PE-349 Leptin Induces Physiological and Compensated Growth of the Left Ventricles Following Myocardial Infarction in Vivo(Diabetes/Obesity/Metabolic syndrome-7 (H) PE59,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Abe Yukiko; Ono Koh; Kawamura Teruhisa; Miyamoto Shoichi; Wada Hiromichi; Horie Takahiro; Shimatsu Akira; Kita Toru; Hasegawa Koji

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

  
• PE-245 Adipocyte-derived Serotonin Regulates Adipocyte Differentiation via an Autocrine/paracrine Mechanism(Diabetes/Obesity/Metabolic syndrome-8 (H) PE41,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Ono Koh; Horie Takahiro; Abe Yukiko; Kawamura Teruhisa; Shimatsu Akira; Kita Toru; Hasegawa Koji

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

  
• OE-196 Identification of Signaling Pathways that Mediate Myocardial GLUT4 Translocation using a Novel Lenti Viral-mediated GLUT4 Reporter Gene(Metabolism/Biochemistry/Energetics-1 (H) OE33,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Horie Takahiro; Ono Koh; Abe Yukiko; Kawamura Teruhisa; Shimatsu Akira; Hasegawa Koji; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

  
• PE-263 Neural Cell Adehesion Molecule is Upregulated by Metabolic Stress and Enhances the Cardiomyocyte Survival(PE044,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Nagao Kazuya; Ono Koh; Horie Takahiro; Kinoshita Minako; Nishi Hitoo; Tamaki Yodo; Kuwabara Yasuhide; Iwanaga Yoshitaka; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• FRS-064 NF-kB-dependent Induction of MicroRNA-146 Downregulates ErbB4 and may be Involved in the Deterioration of Cardiomyocyte Survival(FRS13,Novel Molecular Mechanisms of Heart Failure 2 (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Horie Takahiro; Ono Koh; Iwanaga Yoshitaka; Nishi Hitoo; Nagao Kazuya; Kinoshita Minako; Mori Rieko; Kuwabara Yasuhide; Hasegawa Koji; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• たこつぼ型心筋症に無症候性冠動脈3枝病変を合併した一例

  小松(藤井)貴義; 渡部宏俊; 豊田俊彬; 塩見紘樹; 田崎淳一; 堀江貴裕; 加藤貴雄; 齋藤成達; 木村剛

  日本循環器学会近畿地方会(Web), 2018

  
• MicroRNA-33 Maintains Cellular Cholesterol Content in Fibroblasts and Fibrotic Response in Heart

  Masataka Nishiga; Takahiro Horie; Yasuhide Kuwabara; Osamu Baba; Tetsushi Nakao; Tomohiro Nishino; Daihiko Hakuno; Yasuhiro Nakashima; Kazuya Nagao; Koji Hasegawa; Toru Kita; Takeshi Kimura; Koh Ono

  CIRCULATION, Nov. 2016

  
• Overexpression of the lincRNA Regulated by Pressure-Overload Leads to Cardiomyocyte Hypertrophy

  Yasuhide Kuwabara; Takahiro Horie; Osamu Baba; Masataka Nishiga; Tetsushi Nakao; Tomohiro Nishino; Fumiko Nakazeki; Satoshi Koyama; Takeshi Kimura; Koh Ono

  JOURNAL OF CARDIAC FAILURE, Sep. 2016

  
• Changes and Physiological Meanings of Serum microRNA during Therapeutic Course of Acute Heart Failure

  Satoshi Koyama; Takashi Kuragaichi; Yukihito Sato; Yasuhide Kuwabara; Takahiro Horie; Osamu Baba; Takeshi Kimura; Koh Ono

  JOURNAL OF CARDIAC FAILURE, Sep. 2016

  
• Relationship between Systemic Remodeling of Extracellular Matrix (ECM) and Clinical Course of the Diseases in Heart Failure

  Kazuya Nagao; Hiroshi Yukawa; Kiyotaka Shimamura; Masataka Nishiga; Takahiro Horie; Koh Ono; Yukihito Sato; Tsukasa Inada; Toshinori Makita; Masaru Tanaka

  JOURNAL OF CARDIAC FAILURE, Sep. 2016

  
• Long Intergenic Noncoding RNA and Myogenin Circuitry Promotes Myoblast Differentiation.

  Yasuhide Kuwabara; Takahiro Horie; Shin Watanabe; Osamu Baba; Takeshi Kimura; Koh Ono

  Keystone Symposia, Noncoding RNAs in Health and Disease, Feb. 2016, Peer-reviewed

  
• マイクロRNA‐33を介した新たな脂質代謝制御機構の解明

  堀江貴裕; 西野共達; 馬場理; 桑原康秀; 木村剛; 尾野亘

  血管, 31 Jan. 2016

  
• MicroRNA-451 Aggravates Lipotoxic Cardiomyopathy through Suppression of the LKB1/AMP Pathway.

  Yasuhide Kuwabara; Takahiro Horie; Osamu Baba; Toru Kita; Takeshi Kimura; Koh Ono

  Basic Cardiovascular Sciences, Jul. 2015, Peer-reviewed

  
• microRNA‐33a/bによる細胞・臓器レベルの脂質代謝制御機構

  尾野亘; 堀江貴裕; 西野共達; 木村剛

  糖尿病, 25 Apr. 2015

  
• miR‐33a/bによる細胞・臓器レベルの脂質代謝制御機構

  尾野亘; 堀江貴裕; 西野共達; 北徹, 木村剛

  血管, 31 Jan. 2015

  
• MicroRNA-33b Knock-in Mice for an Intron of Sterol Regulatory Element-Binding Factor 1 (Srebf1) Exhibit Reduced HDL-C in vivo

  Takahiro Horie; Tomohiro Nishino; Osamu Baba; Yasuhide Kuwabara; Tetsushi Nakao; Masataka Nishiga; Shunsuke Usami; Masayasu Izuhara; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  CIRCULATION, Nov. 2014

  
• イントロンに存在するmicroRNA-33aおよび33bとそのホスト遺伝子SREBP2およびSREBP1間の脂質代謝クロストークの解明

  堀江 貴裕; 尾野 亘; 木村 剛

  医科学応用研究財団研究報告, 2013

  
• Circulating Levels of Vascular Endothelial Growth Factor-C are Closely Associated with Dyslipidemia and Atherosclerosis

  Shuichi Ura; Hiromichi Wada; Shuji Kitaoka; Noriko Satoh-Asahara; Takahiro Horie; Koh Ono; Tomohide Takaya; Rieko Takanabe-Mori; Masaharu Akao; Mitsuru Abe; Tatsuya Morimoto; Toshinori Murayama; Masayuki Yokode; Masatoshi Fujita; Akira Shimatsu; Koji Hasegawa

  CIRCULATION, Nov. 2012

  
• MicroRNA-33 Deficiency Reduced Atherosclerosis Formation In Vivo

  Takahiro Horie; Osamu Baba; Koh Ono; Yasuhide Kuwabara; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2012

  
• MicroRNA 33 Deficiency in Leukocytes Reduced the Lipid Accumulation in Atherosclerotic Plaque in ApoE Knockout Mice

  Osamu Baba; Takahiro Horie; Yasuhide Kuwabara; Masayasu Izuhara; Shunsuke Usami; Tetsushi Nakao; Masataka Nishiga; Tomohiro Nishino; Naoya Sowa; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono

  CIRCULATION, Nov. 2012

  
• Neural Cell Adhesion Molecule is a Cardioprotective Factor Up-regulated In Rodent and Human Failing Heart

  Kazuya Nagao; Koh Ono; Yohei Yamauchi; Motoko Tokunaga; Kohei Fukuchi; Koji Uchiyama; Haruyasu Ito; Fujio Hayashi; Toshinori Makita; Tsukasa Inada; Masaru Tanaka; Takahiro Horie; Hitoo Nishi; Minako Kinoshita; Yasuhide Kuwabara; Katsumi Inoue; Takeshi Kimura

  CIRCULATION, Nov. 2012

  
• 血管内皮増殖因子Cと脂質異常・動脈硬化との関連

  浦 修一; 和田 啓道; 北岡 修二; 浅原 哲子; 堀江 貴裕; 尾野 亘; 赤尾 昌治; 阿部 充; 森本 達也; 村山 敏典; 横出 正之; 島津 章; 長谷川 浩二

  肥満研究, Sep. 2012

  
• MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice

  O. Baba; T. Horie; T. Nakamura; K. Hasegawa; N. Kume; M. Yokode; T. Kita; T. Kimura; K. Ono

  EUROPEAN HEART JOURNAL, Aug. 2012

  
• 血管内皮増殖因子Cは脂質異常及び動脈硬化と関連している

  浦 修一; 和田 啓道; 北岡 修二; 佐藤 哲子; 堀江 貴裕; 尾野 亘; 高谷 智英; 森 利依子; 赤尾 昌治; 阿部 充; 森本 達也; 村山 敏典; 横出 正之; 藤田 正俊; 島津 章; 長谷川 浩二

  糖尿病, Apr. 2012

  
• MicroRNA 26b Encoded by the Intron of Small CTD Phosphatases (SCPs) 1 Has an Antagonistic Effect on its Host Gene and Suppresses Cardiac Hypertrophy

  Naoya Sowa; Koh Ono; Takahiro Horie; Koji Hasegawa; Takeshi Kimura

  CIRCULATION, Nov. 2011

  
• CaMKK beta Contributes To Energy Supply In Adaptive Phase Of Pressure-overload-induced Heart Failure

  Shin Watanabe; Koh Ono; Takahiro Horie; Yasuhide Kuwabara; Osamu Baba; Yoshimasa Chujo; Takechi Kimura

  JOURNAL OF CARDIAC FAILURE, Sep. 2011

  
• Elevated microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular diseases indicate the myocardial damage

  Y. Kuwabara; K. Ono; T. Horie; H. Nishi; S. Watanabe; M. Kinoshita; O. Baba; T. Kita; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2011

  
• Neural cell adhesion molecule is a cardioprotective factor upregulated by metabolic stress

  K. Nagao; K. Ono; T. Horie; Y. Tamaki; Y. Iwanaga; T. Makita; T. Inada; M. Tanaka; T. Kita; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2011

  
• Ca2+/Calmodulin-Dependent Kinase Kinsae Beta Contributes to Energy Supply in Adaptive Phase of Pressure-Overload-Induced Heart Failure

  Shin Watanabe; Koh Ono; Takahiro Horie; Hitoo Nishi; Minako Kinoshita; Yasuhide Kuwabara; Osamu Baba; Takeshi Kimura

  CIRCULATION, Nov. 2010

  
• MiR-146a-induced Inhibition of Neuregulin1-ErbB4 Pathway may be Involved in Deterioration of Cardiotoxicity under Concurrent Chemotherapy with Doxorubicin and Trastuzumab.

  Takahiro Horie; Koh Ono; Hitoo Nishi; Kazuya Nagao; Minako Kinoshita; Shin Watanabe; Yasuhide Kuwabara; Yasuhiro Nakashima; Rieko Takanabe-Mori; Eiichiro Nishi; Koji Hasegawa; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2010

  
• Microrna-27a Regulates Beta-Myosin Heavy Chain Gene Expression by Targeting Thyroid Hormone Receptor Beta 1 in Neonatal Rat Ventricular Myocytes

  Hitoo Nishi; Koh Ono; Takahiro Horie; Minao Kinoshita; Shin Watanabe; Yasuhide Kuwabara; Osamu Baba; Yasuhiro Nakashima; Kazuya Nagao; Rieko Takanabe-Mori; Koji Hasegawa; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2010

  
• MicroRNA-1 and MicroRNA-133a are Useful as Early Diagnostic Biomarkers in Patients with Acute Coronary Syndrome

  Yasuhide Kuwabara; Koh Ono; Takahiro Horie; Hitoo Nishi; Minako Kinoshita; Shin Watanabe; Yasuhiro Nakashima; Kazuya Nagao; Yoji Kojima; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2010

  
• Microrna 26b Family Encoded by the Introns of Small CTD Phosphatases (SCPs) 1 to 3 Suppresses Phenylephrine-Induced Cardiomyocyte Hypertrophy by Targeting TRPC3/6 and GATA4

  Koh Ono; Naoya Sowa; Takahiro Horie; Koji Hasegawa; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2010

  
• Ca2+/calmodulin-dependent kinase kinase beta contributes to energy supply in adaptive phase of pressure-overload-induced heart failure

  S. Watanabe; K. Ono; T. Horie; H. Nishi; Y. Kuwabara; T. Kimura

  EUROPEAN HEART JOURNAL, Sep. 2010

  
• Neural Cell Adhesion Molecule is a Cardioprotective Factor Upregulated by Metabolic Stress

  Kazuya Nagao; Koh Ono; Takahiro Horie; Hitoo Nishi; Minako Kinoshita; Yoji Kojima; Yodo Tamaki; Yasuhide Kuwabara; Yoshitaka Iwanaga; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2009

  
• MicroRNA-15b,-16,-195, And-424, Which Have the Same Seed Sequence, Regulate ADP-rybosylation Factor-like 2 And Cellular ATP Levels in Neonatal Rat Cardiac Myocytes

  Hitoo Nishi; Koh Ono; Takahiro Horie; Kazuya Nagao; Minako Kinoshita; Yasuhide Kuwabara; Rieko T. Mori; Koji Hasegawa; Genzou Takemura; Yoshitaka Iwanaga; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2009

  
• Let-7/miR-98 Family Regulates the Expression of GLUT4 by Targeting MEF-2C in Metabolic Control of Cardiomyocytes

  Naoya Sowa; Koh Ono; Takahiro Horie; Yoshitaka Iwanaga; Hitoo Nishi; Kazuya Nagao; Minako Kinoshita; Rieko Takanabe-Mori; Toru Kita; Takeshi Kimura; Koji Hasegawa

  CIRCULATION, Nov. 2009

  
• Acute Doxorubicin Cardiotoxicity is Associated With miR-146a-induced Inhibition of the Neureglin-ErbB4 Pathway

  Takahiro Horie; Koh Ono; Yoshitaka Iwanaga; Hitoo Nishi; Kazuya Nagao; Mianko Kinoshita; Yasuhide Kuwabara; Rieko Takanabe-Mori; Koji Hasegawa; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2009

  
• MicroRNA-378, Which Exists Intronic Lesion of PGC-1beta, Deteriorate Cardiomyocyte Survival Under Oxidative Stress

  Yasuhide Kuwabara; Koh Ono; Takahiro Horie; Hitoo Nishi; Kazuya Nagao; Shin Watanabe; Yoji Kojima; Minako Kinosita; Rieko Mori; Toru Kita; Takeshi Kimura

  CIRCULATION, Nov. 2009

  
• MicroRNA-15b,-16,-195, and-424 are Involved in the Deterioration of Mitochondrial Function in Cardiomyocytes

  Hitoo Nishi; Koh Ono; Yoshitaka Iwanaga; Takahiro Horie; Kazuya Nagao; Genzou Takemura; Takanabe Rieko Mori; Koji Hasegawa; Toru Kita; Takeshi Kimura

  JOURNAL OF CARDIAC FAILURE, Sep. 2009

  
• Up-Regulated Expression of MicroRNA-143 In Association with Obesity in the Adipose Tissue of Mice Fed High Fat Diet

  Rieko Takanabe; Koh Ono; Tomohide Takaya; Takahiro Horie; Hiromichi Wada; Toru Kita; Akira Shimatsu; Koji Hasegawa

  CIRCULATION, Oct. 2008

  
• Nf-kb-dependent Induction Of Microrna-146 Downregulates Erbb4 And May Be Involved In The Deterioration Of Cardiomyocyte Survival

  Takahiro Horie; Koh Ono; Yoshitaka Iwanaga; Hitoo Nishi; Kazuya Nagao; Minako Kinoshita; Rieko Mori; Koji Hasegawa; Toru Kita

  CIRCULATION, Oct. 2008

  
• MicroRNA-206 controls cardiac myosin heavy chain gene expression by targeting RXR-alpha

  Hitoo Nishi; Koh Ono; Yoshitaka Iwanaga; Takahiro Horie; Minako Kinoshita; Kazuya Nagao; Rieko Mori; Koji Hasegawa; Toru Kita

  CIRCULATION, Oct. 2007

  
• Serotonin in adipose tissue acts as an autocrine factor required for adipocyte differentiation and lipolysis

  Koh Ono; Takahiro Horie; Yukiko Abe; Teruhisa Kawamura; Minako Kinoshita; Hitoo Nishi; Kazuya Nagao; Noriko Satoh; Akira Shimatsu; Toru Kita; Koji Hasegawa

  CIRCULATION, Oct. 2007

  
• Oxidative stress induces GLUT4 translocation by dual AMPK kinase activation in cardiac myocytes

  Horie Takahiro; Koh Ono; Yukiko Abe; Teruhisa Kawamura; Hiromichi Wada; Minako Kinoshita; Kazuya Nagao; Hitoo Nishi; Akira Shimatsu; Toru Kita; Koji Hasegawa

  CIRCULATION, Oct. 2007

  
• Identification of signaling pathways that mediate the oxidative stress-induced translocation of myocardial GLUT4 using a novel lenti-viral mediated GLUT4 reporter gene

  Takahiro Horie; Koh Ono; Yukiko Abe; Teruhisa Kasamura; Akira Shimatsu; Koji Hasegawa; Toru Kita

  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Dec. 2006

  
• Identification of signaling pathways that mediate the oxidative stress-induced translocation of myocardial GLUT4 using a novel lenti-viral-mediated GLUT4 reporter gene

  Takahiro Horie; Koh Ono; Yukiko Abe; Teruhisa Kawamura; Akira Shimatsu; Toru Kita; Koji Hasegawa

  JOURNAL OF CARDIAC FAILURE, Oct. 2006

  
• Identification of signaling pathways that mediate the oxidative stress-induced translocation of myocardial GLUT4 using a novel lenti viral-mediated GLUT4 reporter gene

  Takahiro Horie; Koh Ono; Yukiko Abe; Teruhisa Kawamura; Akira Shimatsu; Koji Hasegawa; Toru Kita

  CIRCULATION, Oct. 2006

  
• Adipocyte-derived serotonin regulates adipocyte differentiation via an autocrine/paracrine mechanism

  Koh Ono; Takahiro Horie; Yukiko Abe; Teruhisa Kawamura; Akira Shimatsu; Koji Hasegawa; Toru Kita

  JOURNAL OF CARDIAC FAILURE, Oct. 2006

  
• 心アミロイドーシスにおける血中トロポニンTの測定

  加藤貴雄; 佐藤幸人; 宮本忠司; 松岡龍彦; 長央和也; 堀江貴裕; 中島康弘; 片岡一明; 鷹津良樹

  第8回日本心不全学会学術集会, Oct. 2004, Peer-reviewed

  
• ペースメーカー不全を来ししきい値の急上昇で発見されたアミロイドーシスの一例

  KATO TAKAO; MIYAMOTO TADASHI; NAGAO KAZUYA; HORIE TAKAHIRO; NAKAJIMA YASUHIRO; KATAOKA KAZUAKI; TAKATSU YOSHIKI

  Circ J, 20 Apr. 2004

  
• 両側内胸動脈にも解離の及んだ冠動脈自然解離の一例

  NAGAO KAZUYA; TAKATSU YOSHIKI; MIYAMOTO TADASHI; KATAOKA KAZUAKI; NAKAJIMA YASUHIRO; KATO TAKAO; HORIE TAKAHIRO; NOMOTO SHIN'ICHI; KIN KEN'ICHI

  Circ J, 20 Apr. 2004

  
• 長期透析が経皮的冠動脈インターベンション後の再狭窄に及ぼす影響

  中島康弘; 片岡一明; 谷口良司; 宮本忠司; 星野康三; 牧山武; 加藤貴雄; 堀江貴裕; 長央和也

  Jpn J Interv Cardiol, 10 Feb. 2004

  
• NIRステント留置後の再狭窄予測因子に関する検討―ステント長は再狭窄率に影響しない

  宮本忠司; 永井康三; 佐藤幸人; 牧山武; 長央和也; 中島康弘; 加藤貴雄; 堀江貴裕; 谷口良司

  Jpn J Interv Cardiol, 10 Feb. 2004

  
• 第一回 臨床心不全フォーラム カルペリチドが有用であった大動脈弁狭窄症に冠動脈疾患を合併した心不全の1例

  HORIE TAKAHIRO; KATAOKA KAZUAKI; NAGAO KAZUYA; KATO TAKAO; NAKASHIMA YASUHIRO; MIYAMOTO TADASHI; TAKATSU YOSHIKI

  循環器科, 28 Jan. 2004

  
• しきい値の急上昇をきたしペースメーカー不全をきたして発見されたアミロイドーシスの1例

  KATO TAKAO; MIYAMOTO TADASHI; NAGAO KAZUYA; HORIE TAKAHIRO; NAKAJIMA YASUHIRO; KATAOKA KAZUAKI; TAKATSU YOSHIKI

  血管と心研究会誌, Dec. 2003

  
• Radiusステント留置時の後拡張に関する検討

  片岡 一明; 永井 康三; 李 俊峡; 長央 和也; 加藤 貴雄; 堀江 貴裕; 中島 康弘; 牧山 武; 宮本 忠司; 鷹津 良樹

  Journal of Cardiology, Aug. 2003

  
• 孤立,腫りゅう形成型の心転移を認めた転移性子宮筋腫の一例

  HORIE TAKAHIRO; MIYAMOTO TADASHI; KATAOKA KAZUAKI; NAKASHIMA YASUHIRO; KATO TAKAO; NAGAO KAZUYA; TAKATSU YOSHIKI

  診療と新薬, 28 Jan. 2003

  
• 経皮的血管縫合器(Prostar XL/Closer)によるPCI後の縫合止血の成績とその検討

  中島康弘; 永井康三; 牧山武; 加藤貴雄; 堀江貴裕; 李俊峡; 宮本忠司; 鷹津良樹

  Jpn J Interv Cardiol, 10 Jun. 2002

  
• Radiusステントの初期および慢性期成績の検討

  永井康三; 宮本忠司; 李俊峡; 牧山武; 中島康弘; 堀江貴裕; 加藤貴雄; 鷹津良樹

  Jpn J Interv Cardiol, 10 Jun. 2002

  
• 慢性腎不全患者の心疾患 慢性腎不全透析患者における冠動脈造影所見および治療成績の検討

  中島康弘; 宮本忠司; 谷口良司; 永井康三; 牧山武; 加藤貴雄; 堀江貴裕; 佐藤幸人; 鷹津良樹

  診療と新薬, 28 Feb. 2002

  

Awards

• 日本循環器学会, YIA
• 日本動脈硬化学会, 若手奨励賞
• 日本臨床分子医学会, 学術奨励賞
• 日本血管生物医学会, YIA

External funds: Kakenhi

• Functional analysis of cholesterol-related long non-coding RNAs and their clinical application

  Grant-in-Aid for Scientific Research (C)

  Basic Section 54040:Metabolism and endocrinology-related

  Kyoto University

  Takahiro Horie

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  非コードRNA;心血管代謝性疾患;コレステロール;ノンコーディングRNA;動脈硬化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08904/
• Elucidation of the functions of long non-coding RNA in cardiovascular diseases

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53020:Cardiology-related

  Kyoto University

  Koh Ono

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  心肥大;心不全;非コードRNA;非アルコール性脂肪肝炎;線維化;コレステロール;動脈硬化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03675/
• Investigation of the role of microRNAs in the formation of liver fibrosis

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Horie Takahiro

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  非アルコール性脂肪肝炎;非コードRNA;マイクロRNA;コレステロール;脂肪酸;NASH;SREBP;microRNA;治療応用;内科;脂質;トランスレーショナルリサーチ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09860/
• Elucidation of global metabolic control mechanisms by microRNA-33a/b and development of specific regulatory strategy using artificial nucleic acid

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Koh Ono

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  マイクロRNA;iPS細胞;核酸医薬;代謝;人工核酸;iPSC

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04177/
• Elucidation of the regulatory mechanism of lipid metabolism by intronic microRNA-33a, -33b

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  TAKAHIRO HORIE

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  脂質代謝;マイクロRNA;SREBP;動脈硬化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461144/
• Elucidation of the functions of microRNA-33 in homeostasis in vivo

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Koh Ono

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  マイクロRNA;動脈硬化;線維化;ナノ粒子;HDL-C;炎症;コレステロール;慢性炎症;骨髄

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293186/
• Investigation of the novel prevention and treatment for atherosclerosis by microRNA modulation

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  TAKAHIRO HORIE

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  マイクロRNA;動脈硬化;HDL;脂質代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790753/
• Elucidation of the functions of miR-33a/b in cholesterol homeostasis

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  KOH ONO

  From 18 Nov. 2011, To 31 Mar. 2014, Project Closed

  マイクロRNA;HDL-C;動脈硬化;ABCA1;SREBP-2;SREBP-1;脂肪肝;動脈瘤;心肥大

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390211/
• Elucidation of the function of microRNAs on cardiovascular and metabolic disease : Investigation for a novel therapy by regulating microRNAs

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Takahiro HORIE

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  マイクロRNA;動脈硬化;コレステロール;HDL;心不全;ドキソルビシン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790703/
• 非コードRNAによる褐色脂肪細胞・ベージュ脂肪細胞の活性化機構の解明

  Grant-in-Aid for Scientific Research (C)

  Basic Section 54040:Metabolism and endocrinology-related

  Kyoto University

  堀江 貴裕

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ノンコーディングRNA;肥満;褐色脂肪細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K07988/
• Elucidation of the pathophysiology of aortic aneurysms and development of novel therapeutic agents to inhibit their progression and promote their regression

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53020:Cardiology-related

  Kyoto University

  尾野 亘

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  大動脈瘤;マイクロRNA;シングルセル解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02904/
• Elucidation of the pathophysiology of aortic aneurysms and development of novel therapeutic agents to inhibit their progression and promote their regression

  Grant-in-Aid for Scientific Research (B)

  Basic Section 53020:Cardiology-related

  Kyoto University

  尾野 亘

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  大動脈瘤;マイクロRNA;シングルセル解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27595/