Coppo, Roberto(Graduate School of Medicine, Medicine) | Activity Database on Education and Research, Kyoto University

Coppo, Roberto

Graduate School of Medicine, Medicine Program-Specific Senior Lecturer/Program-Specific Junior Associate Professor

Last Updated :2026/06/15

Basic Information

Email Address

Email Address
coppo.roberto.4skyoto-u.ac.jp

Professional Memberships

From 2023, To Present
The Japanese Association for Molecular Target Therapy of Cancer

From 2022, To Present
The Japanese Association for Metastasis Research

From 2017, To Present
The Japanese Cancer Association

Academic Degree

05 Oct. 2012
M.S. (University of Turin)

31 Jan. 2017
Ph.D. (University of Turin)

Academic Resume (Undergraduate School/Majors)

University of Eastern Piedmont“Amedeo Avogadro”, School of Medicine,Dept.of Health Sciences,Bachelor's Degree in Biotechnology, 卒業

State Industrial Technical Institute "Q.Sella", Scientific High School,Experimental Course for Technological Scientific High School "Brocca Project", 卒業

Research History

From Apr. 2026, To Present
Kyoto University, Graduate School of Medicine, Department of Immunology, Specially Appointed Lecturer

From Apr. 2025, To Mar. 2026
Kyoto University, Graduate School of Medicine, Dept. of Clinical Bio-Resource Research and Development, Program-Specific Associate Professor

From Sep. 2024, To Mar. 2025
Kyoto University, Graduate School of Medicine, Dept. of Clinical Bio-Resource Research and Development, Postdoctoral Research Fellow

From Sep. 2022, To Aug. 2024
Kyoto University, Graduate School of Medicine, Dept. of Clinical Bio-Resource Research and Development, JSPS Postdoctoral Research Fellow

From Apr. 2018, To Aug. 2022
Kyoto University, Graduate School of Medicine, Dept. of Clinical Bio-Resource Research and Development, Postdoctoral Research Fellow

From Apr. 2017, To Mar. 2018
Osaka International Cancer Institute, Postdoctoral Research Fellow

ID,URL

ORCID ID
0000-0002-6525-5317
J-Global ID
202401013546570347
External link
https://immunol.med.kyoto-u.ac.jp/en/

researchmap URL

https://researchmap.jp/coppo_roberto

Last Updated :2026/06/15

Research

Research Interests

Mechanisms of non-genetic resistance in cancer

CRISPR gene editing

Bioinformatics

Cancer cell plasticity

Organoid cultures for cancer modeling

Papers

Three-dimensional reconstruction of a biliary system in a bioengineered liver using decellularized scaffold
Hiroshi Horie; Ken Fukumitsu; Yusuke Hanabata; Takuma Karasuyama; Kentaro Iwaki; Fumiaki Munekage; Kenta Makino; Takashi Ito; Katsuhiro Tomofuji; Hidenobu Kojima; Satoshi Ogiso; Elena Yukie Uebayashi; Hiroyuki Uematsu; Roberto Coppo; Kunishige Onuma; Masahiro Inoue; Takamichi Ishii; Etsuro Hatano
Scientific Reports, 10 Feb. 2026
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Xenograft-Derived Human Breast Cancer Organoids Can Form Chimeras with Host Mouse Mammary Epithelial Cells Which Promote Tumor Cell Proliferation
Hiroyuki Uematsu; Chieko Saito; Jumpei Kondo; Kunishige Onuma; Roberto Coppo; Hiroko Endo; Takahiro Nakayama; Katsuhide Yoshidome; Taisei Nomura; Arihiro Kohara; Masahiro Inoue
Organoids, 06 Feb. 2026

Organoids as a Tool for Assessing Drinking Water Safety and Guidelines Relevance
Roberto Coppo; Edoardo Bertone
Organoids, 04 Dec. 2025, Corresponding author

Interaction between gastric cancer organoids and peritoneal mesothelial cells suppresses the growth of gastric cancer organoids and induces drug resistance
Hiroyuki Uematsu; Shota Shimizu; Kunishige Onuma; Roberto Coppo; Yumi Sato; Tomoyuki Matsunaga; Yoshiyuki Fujiwara; Masahiro Inoue
Human Cell, 13 Nov. 2025

IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC
Tomohiko Sunami; Roberto Coppo; Kunishige Onuma; Jumpei Kondo; Hiroyuki Uematsu; Daisuke Hoshi; Yoshihiro Yamamoto; Osamu Kikuchi; Shinya Ohashi; Yasuhide Takeuchi; Kazuto Kugou; Yoshiaki Hasegawa; Yoshiro Itatani; Kazutaka Obama; Yoshitaka Hippo; Manabu Muto; Atsushi Yamada; Masahiro Inoue
12 Sep. 2025

Patient-Derived Tumor Organoids to Model Cancer Cell Plasticity and Overcome Therapeutic Resistance
Roberto Coppo; Masahiro Inoue
Cells, Sep. 2025, Corresponding author

Dynamic change of polarity in spread through air spaces of pulmonary malignancies
Yoshiaki Matsuura; Kunishige Onuma; Roberto Coppo; Hiroyuki Uematsu; Jumpei Kondo; Aya Miyagawa‐Hayashino; Naoko Takeda‐Miyata; Kenji Kameyama; Tatsuo Furuya; Satoru Okada; Masanori Shimomura; Masayoshi Inoue; Masahiro Inoue
The Journal of Pathology, 13 Jan. 2025
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Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment
Yi‐Kai Lin; Roberto Coppo; Kunishige Onuma; Hiroko Endo; Jumpei Kondo; Sadahiro Iwabuchi; Shinichi Hashimoto; Yoshiro Itatani; Kazutaka Obama; Masahiro Inoue
Cancer Science, 19 Sep. 2024
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Clonal Origin and Lineage Ambiguity in Mixed Neuroendocrine Carcinoma of the Uterine Cervix
Masamune Masuda; Keita Iida; Sadahiro Iwabuchi; Mie Tanaka; Satoshi Kubota; Hiroyuki Uematsu; Kunishige Onuma; Yoji Kukita; Kikuya Kato; Shoji Kamiura; Aya Nakajima; Roberto Coppo; Mizuki Kanda; Kiyoshi Yoshino; Yutaka Ueda; Eiichi Morii; Tadashi Kimura; Jumpei Kondo; Mariko Okada-Hatakeyama; Shinichi Hashimoto; Masahiro Inoue
The American Journal of Pathology, Mar. 2024

Tracking the growth fate of single cells and isolating slow-growing cells in human colorectal cancer organoids
Roberto Coppo; Jumpei Kondo; Kunishige Onuma; Masahiro Inoue
STAR Protocols, Sep. 2023

De-differentiation in cultures of organoids from luminal-type breast cancer is restored by inhibition of NOTCH signaling
Hiroyuki Uematsu; Chieko Saito; Jumpei Kondo; Kunishige Onuma; Roberto Coppo; Yukiko Mori; Manabu Muto; Yuichiro Kikawa; Manami Tada; Tomoharu Sugie; Masahiro Inoue
Human Cell, 27 Aug. 2023

Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK‐dependent colorectal cancer
Shota Shimizu; Jumpei Kondo; Kunishige Onuma; Roberto Coppo; Kasumi Ota; Mayumi Kamada; Yohei Harada; Yoshihisa Tanaka; Mai Adachi Nakazawa; Yoshinori Tamada; Yasushi Okuno; Kenji Kawada; Kazutaka Obama; Robert J. Coffey; Yoshiyuki Fujiwara; Masahiro Inoue
Cancer Science, 25 Jun. 2023

Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors
Katsuhiro Tomofuji; Jumpei Kondo; Kunishige Onuma; Roberto Coppo; Hiroshi Horie; Koki Oyama; Eiji Miyoshi; Ken Fukumitsu; Takamichi Ishii; Etsuro Hatano; Masahiro Inoue
Hepatology Communications, 14 Apr. 2023

Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
Roberto Coppo; Jumpei Kondo; Keita Iida; Mariko Okada; Kunishige Onuma; Yoshihisa Tanaka; Mayumi Kamada; Masayuki Ohue; Kenji Kawada; Kazutaka Obama; Masahiro Inoue
iScience, Feb. 2023
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GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma
M. Scatolini; A. Patel; E. Grosso; M. Mello-Grand; P. Ostano; R. Coppo; M. Vitiello; T. Venesio; A. Zaccagna; A. Pisacane; I. Sarotto; D. Taverna; L. Poliseno; D. Bergamaschi; G. Chiorino
British Journal of Dermatology, 01 Jan. 2022

Distinct and interchangeable growing patterns in colorectal cancer stem-like cells are regulated by Musashi-1
Roberto Coppo; Jumpei Kondo; Keita Iida; Mariko Okada; Kunishige Onuma; Yoshihisa Tanaka; Mayumi Kamada; Masayuki Ohue; Kenji Kawada; Kazutaka Obama; Masahiro Inoue
bioRxiv, 26 Nov. 2021

ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3
Roberto Coppo; Francesca Orso; Federico Virga; Alberto Dalmasso; Desirée Baruffaldi; Lei Nie; Fabiana Clapero; Daniela Dettori; Lorena Quirico; Elena Grassi; Paola Defilippi; Paolo Provero; Donatella Valdembri; Guido Serini; Mehran M. Sadeghi; Massimiliano Mazzone; Daniela Taverna
Cancer Letters, Jul. 2021

Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix
Mie Tanaka; Jumpei Kondo; Kensuke Kaneko; Hiroko Endo; Kunishige Onuma; Roberto Coppo; Masamune Masuda; Shoji Kamiura; Kiyoshi Yoshino; Yutaka Ueda; Hideaki Kakeya; Tadashi Kimura; Masahiro Inoue
Human Cell, 06 Mar. 2021

O23: CHARACTERISING PATIENT-DERIVED COLORECTAL CANCER TISSUE-ORIGINATED ORGANOIDAL SPHEROIDS FOR HIGH-THROUGHPUT MICROFLUIDIC APPLICATIONS
MI Khot; M Levenstein; R Coppo; J Kondo; M Inoue; N Kapur; DG Jayne
British Journal of Surgery, 01 Mar. 2021

Role of miRNAs in tumor and endothelial cell interactions during tumor progression
Francesca Orso; Lorena Quirico; Daniela Dettori; Roberto Coppo; Federico Virga; Livia C Ferreira; Camilla Paoletti; Désirée Baruffaldi; Elisa Penna; Daniela Taverna
Seminars in Cancer Biology, Feb. 2020

Axl-148b chimeric aptamers inhibit breast cancer and melanoma progression
Lorena Quirico; Francesca Orso; Carla L. Esposito; Sofia Bertone; Roberto Coppo; Laura Conti; Silvia Catuogno; Federica Cavallo; Vittorio de Franciscis; Daniela Taverna
International Journal of Biological Sciences, 2020

miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
Francesca Orso; Lorena Quirico; Federico Virga; Elisa Penna; Daniela Dettori; Daniela Cimino; Roberto Coppo; Elena Grassi; Angela Rita Elia; Davide Brusa; Silvia Deaglio; Maria Felice Brizzi; Michael B. Stadler; Paolo Provero; Michele Caselle; Daniela Taverna
Cancer Research, 31 Aug. 2016

Misc.

Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix (Mar, 10.1007/s13577-021-00511-5, 2021)
Mie Tanaka; Jumpei Kondo; Kensuke Kaneko; Hiroko Endo; Kunishige Onuma; Roberto Coppo; Masamune Masuda; Shoji Kamiura; Kiyoshi Yoshino; Yutaka Ueda; Hideaki Kakeya; Tadashi Kimura; Masahiro Inoue
HUMAN CELL, May 2021

Cancer Tissue-Originated Spheroid(CTOS)法を用いた結腸直腸癌における腫瘍内多様性の解析(Characterization of tumor subclonal heterogeneity in colorectal cancer using cancer tissue-originated spheroid method)
Coppo Roberto; 近藤純平; 遠藤洋子; 井上正宏
日本癌学会総会記事, Sep. 2018

Presentations

How to target a moving system? Organoid models, cellular plasticity, and CRISPR strategies against drug-resistant cancer cells
Roberto Coppo; Masahiro Inoue
JSPS Alumni Association in Australia (JSPSAAA) Annual Symposium, University of New South Wales, Sydney (virtual), 26 Nov. 2025, Invited

Identification of a treatment-induced factor in resistant colorectal cancer persister cells and its suppression to prevent tumor regrowth
Roberto Coppo
The 29th Annual Meeting of Japanese Association for Molecular Target Therapy of Cancer, Sapporo, 03 Jul. 2025

A CRISPR dropout screening to identify genetic vulnerabilities in a slow-growing subset of colorectal cancer cells
83th Annual Meeting of the Japanese Cancer Association, Fukuoka, 20 Sep. 2024

Epigenetic regulation of drug-tolerant persister (DTP) cell regrowth after chemotherapy in colorectal cancer organoids
The 28th Annual Meeting of Japanese Association for Molecular Target Therapy of Cancer, Tokyo, 20 Jun. 2024

Unraveling non-genetic heterogeneity, cellular plasticity, and drug resistance in patient-derived colorectal cancer organoids
65th Advanced Research Seminar, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, 22 Jan. 2024, Invited

Analysis of intra-tumor heterogeneity in colorectal cancer using the cancer tissue-originated spheroid (CTOS) method
77th Annual Meeting of the Japanese Cancer Association, Osaka, 28 Sep. 2018

Role of ESDN/DCBLD2/CLCP1 protein in melanoma progression
ABCD Meeting "Mechanisms of signal transduction", Padua, Italy, 17 May 2014

Books and Other Publications

What Are Cancer Stem Cells? Redefining Stemness in Cancer [1.6 The Evolving Theory of Cancer Stem Cells]
Roberto Coppo; Masahiro Inoue, Joint work
Experimental Medicine, Vol. 43, No. 12, Yodosha, Jul. 2025
Find Kyoto University's collection of books :

External funds: Kakenhi

Functional single cell analysis and drug screening in tumor organoids to target slow-growing cells
Grant-in-Aid for JSPS Fellows
Basic Section 50010:Tumor biology-related
Kyoto University
COPPO Roberto;井上正宏
From 08 Mar. 2023, To 31 Mar. 2025, Project Closed
がん（Cancer）;多様性（Diversity）;可塑性（Plasticity）;増殖運命（Proliferative Fate）;薬剤耐性（Drug Resistance）;がん;多様性;可塑性;増殖運命;薬剤耐性
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KF0212/

Organoid-based personalized therapy for thymic epithelial tumors using the molecular targeting drug
Grant-in-Aid for Scientific Research (C)
Basic Section 55040:Respiratory surgery-related
Kyoto Prefectural University of Medicine
下村雅律
From 01 Apr. 2025, To 31 Mar. 2028, Granted
胸腺上皮性腫瘍;オルガノイド;CTOS
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K12112/

Organ-dependent carcinogenesis mechanisms in hereditary gastrointestinal tumors
Grant-in-Aid for Scientific Research (C)
Basic Section 50010:Tumor biology-related
Kyoto University
山田敦
From 01 Apr. 2025, To 31 Mar. 2028, Granted
遺伝性消化管腫瘍;オルガノイド培養;臓器依存的
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K10465/

Targeting vulnerabilities in drug-resistant slow-growing colorectal cancer cells
Grant-in-Aid for Scientific Research (C)
Basic Section 50010:Tumor biology-related
Kyoto University
COPPO Roberto
From 01 Apr. 2025, To 31 Mar. 2028, Granted
がん;薬剤耐性;可塑性;CRISPRスクリーニング;緩慢増殖細胞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K10421/

Functional single-cell analysis of the stem cell plasticity associated with drug-tolerant persister cells in colorectal cancer
Grant-in-Aid for Early-Career Scientists
Basic Section 50010:Tumor biology-related
Kyoto University
COPPO Roberto
From 01 Apr. 2022, To 31 Mar. 2023, Discontinued
Colorectal cancer;Tumor organoids;Cell plasticity;Drug tolerance;Musashi-1;colorectal cancer;tumor organoids;cancer stem cells;cell plasticity;drug resistance
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K15539/

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Coppo, Roberto

Basic Information

Email Address

Email Address

Professional Memberships

Academic Degree

Academic Resume (Undergraduate School/Majors)

Research History

ID,URL

ORCID ID

J-Global ID

External link

researchmap URL

Research

Research Interests

Papers

Misc.

Presentations

Books and Other Publications

External funds: Kakenhi

Academic, Social Contribution

Social Contribution