Basic Information

Faculty

• Faculty of Medicine

Concurrent Affiliation

• Graduate School of Medicine, 医学研究科 医学専攻

Academic Degree

• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  201401034651071623

researchmap URL

• https://researchmap.jp/7000008763

Research

Research Topics, Overview of the research

• Research Topics

  遺伝性不整脈疾患、心疾患の研究

Research Areas

• Life sciences, Cardiology

Papers

• SCN5A variant type-dependent risk prediction in Brugada syndrome.

  Takanori Aizawa; Takeru Makiyama; Hai Huang; Tomohiko Imamura; Megumi Fukuyama; Keiko Sonoda; Koichi Kato; Takashi Hisamatsu; Yuko Nakamura; Kenji Hoshino; Junichi Ozawa; Hiroshi Suzuki; Kazushi Yasuda; Hisaaki Aoki; Takashi Kurita; Yoko Yoshida; Tsugutoshi Suzuki; Yoshihide Nakamura; Yoshiharu Ogawa; Shintaro Yamagami; Hiroshi Morita; Shinsuke Yuasa; Masakazu Fukuda; Makoto Ono; Hidekazu Kondo; Naohiko Takahashi; Seiko Ohno; Yoshihisa Nakagawa; Koh Ono; Minoru Horie

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 05 Feb. 2025

  
• Sex-specific clinical course of young patients with Brugada syndrome

  Tomohiko Imamura; Takeru Makiyama; Junichi Ozawa; Keiko Sonoda; Koichi Kato; Takanori Aizawa; Asami Kashiwa; Jingshan Gao; Hai Huang; Yuta Yamamoto; Hirohiko Kohjitani; Hisaaki Aoki; Seiichi Watanabe; Shota Muraji; Takuro Kojima; Masao Yoshinaga; Seiko Ohno; Hiroshi Suzuki; Naokata Sumitomo; Yoshihisa Nakagawa; Koh Ono; Minoru Horie; Takeshi Kimura

  European Heart Journal, 05 Feb. 2025

  
• Comparison of Feature Extraction Methods for Prognosis Prediction in Hereditary Arrhythmia Disease

  MITANI Takeshi; OKAMOTO Yuji; HIROHIKO Kohjitani; AIZAWA Takanori; MAKIYAMA Takeru; OHNO Seiko; HORIE Minoru; OKUNO Yasushi

  Proceedings of the Annual Conference of JSAI, 2024

  
• 心疾患の発症機構解明と新たな治療戦略 iPS細胞を用いたカルモジュリン遺伝子異常による致死性不整脈疾患の病態解明(Elucidation of the pathogenesis of heart diseases and development of new therapeutic strategies Modeling calmodulin-related life-threatening arrhythmias using iPS cells)

  Makiyama Takeru; Gao Jingshan; Yamamoto Yuta; Kobayashi Takuya; Takanori Aizawa; Huang Hai; Kasahiwa Asami; Imamura Tomohiko; Aoki Hisaaki; Kato Koichi; Fukuyama Megumi; Toyoda Futoshi; Ohno Seiko; Makita Naomasa; Kurebayashi Nagomi; Murayama Takashi; Horie Miinoru; Kimura Takeshi; Ono Koh

  The Journal of Physiological Sciences, May 2024

  
• Fatal Arrhythmic Events are Higher in Non-missense than in Missense Variants in SCN5A-positive Brugada Syndrome(タイトル和訳中)

  Aizawa Takanori; Makiyama Takeru; Huang Hai; Imamura Tomohiko; Fukuyama Megumi; Sonoda Keiko; Kato Koichi; Ohno Seiko; Horie Minoru; Ono Koh

  日本循環器学会学術集会抄録集, Mar. 2024

  
• Histological Characteristics of a Rat Model of Cardiac Laminopathy Carrying Lmna p.S143P(タイトル和訳中)

  Huang Hai; Makiyama Takeru; Shirai Manabu; Wakabayashi Masaki; Yoshida Morikatsu; Nishiuchi Suguru; Moriuchi Kenji; Gao Jing Shan; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Kohjitani Hirohiko; Kato Koichi; Ohno Seiko; Nakagawa Yasuaki; Yamaguchi Osamu; Kuwahara Koichiro; Makita Naomasa; Horie Minoru; Kimura Takeshi; Ono Koh

  日本循環器学会学術集会抄録集, Mar. 2024

  
• ミスセンス変異Lmna-S143Pを有するLMNA関連心筋症のラットモデル(Rat Model of LMNA-related Cardiomyopathy Carrying a Missense Mutation, Lmna-S143P)

  Huang Hai; Makiyama Takeru; Shirai Manabu; Wakabayashi Masaki; Ishikawa Taisuke; Nishiuchi Suguru; Moriuchi Kenji; Gao Jingshan; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Kohjitani Hirohiko; Kato Koichi; Ohno Seiko; Nakagawa Yasuaki; Yamaguchi Osamu; Kuwahara Koichiro; Makita Naomasa; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2023

  
• 遺伝性鉄芽球性貧血、続発性鉄過剰症に合併した肺高血圧症の一例

  太田 優雅子; 木下 秀之; 牧山 武; 福田 祐紀; 金森 敬彦; 柳澤 洋; 森内 健史; 稲住 英明; 塩見 紘樹; 中川 靖章; 桑原 宏一郎

  日本肺高血圧・肺循環学会学術集会抄録集, Jun. 2023

  
• Electrophysiological Analysis of hiPSC-Derived Cardiomyocytes Using a Patch-Clamp Technique

  Yuta Yamamoto; Sayako Hirose; Yimin Wuriyanghai; Daisuke Yoshinaga; Takeru Makiyama

  Methods in Molecular Biology, 2021

  
• Multielectrode Array Assays Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

  Daisuke Yoshinaga; Yimin Wuriyanghai; Takeru Makiyama

  Methods in Molecular Biology, 2021

  
• KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels

  Shuhei Tsuji; Chiharu Otani; Takahiro Horie; Shin Watanabe; Osamu Baba; Naoya Sowa; Yuya Ide; Asami Kashiwa; Takeru Makiyama; Hirohiko Imai; Yasuhiro Nakashima; Tomohiro Yamasaki; Sijia Xu; Kazuki Matsushita; Keita Suzuki; Fuquan Zou; Eitaro Kume; Koji Hasegawa; Takeshi Kimura; Akira Kakizuka; Koh Ono

  Biomedicine & Pharmacotherapy, Jan. 2024

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• 不整脈原性心筋症における遺伝子スクリーニングの貢献(Contribution of Genetic Screening for Arrhythmogenic Cardiomyopathy)

  Fukuyama Megumi; Ohno Seiko; Kato Koichi; Ozawa Tomoya; Okuyama Yusuke; Fujii Yusuke; Sawayama Yuichi; Higo Yousuke; Asada Kohei; Yagi Noriaki; Miyamoto Akashi; Sakai Hiroshi; Makiyama Takeru; Yamamoto Takashi; Horie Minoru; Nakagawa Yoshihisa

  日本循環器学会学術集会抄録集, Mar. 2021

  
• TAD boundary deletion causes PITX2-related cardiac electrical and structural defects

  Manon Baudic; Hiroshige Murata; Fernanda M. Bosada; Uirá Souto Melo; Takanori Aizawa; Pierre Lindenbaum; Lieve E. van der Maarel; Amaury Guedon; Estelle Baron; Enora Fremy; Adrien Foucal; Taisuke Ishikawa; Hiroya Ushinohama; Sean J. Jurgens; Seung Hoan Choi; Florence Kyndt; Solena Le Scouarnec; Vincent Wakker; Aurélie Thollet; Annabelle Rajalu; Tadashi Takaki; Seiko Ohno; Wataru Shimizu; Minoru Horie; Takeshi Kimura; Patrick T. Ellinor; Florence Petit; Yves Dulac; Paul Bru; Anne Boland; Jean-François Deleuze; Richard Redon; Hervé Le Marec; Thierry Le Tourneau; Jean-Baptiste Gourraud; Yoshinori Yoshida; Naomasa Makita; Claude Vieyres; Takeru Makiyama; Stephan Mundlos; Vincent M. Christoffels; Vincent Probst; Jean-Jacques Schott; Julien Barc

  Nature Communications, 20 Apr. 2024

  
• Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants.

  Asami Kashiwa; Hideki Itoh; Takeru Makiyama; Yuko Wada; Junichi Ozawa; Koichi Kato; Megumi Fukuyama; Tadashi Nakajima; Seiko Ohno; Minoru Horie

  Heart rhythm, 15 Feb. 2024

  
• Calmodulinopathy: A Common Cause of Critical Cardiac Phenotypes in Fetus and Infancy(タイトル和訳中)

  Fukuyama Megumi; Horie Minoru; Kato Koichi; Ozawa Tomoya; Fujii Yusuke; Okuyama Yusuke; Makiyama Takeru; Ohno Seiko; Nakagawa Yoshihisa

  日本循環器学会学術集会抄録集, Mar. 2023

  
• RYR2遺伝子変異を有する家族性CPVT患者とde Novo CPVT患者の表現型の違い(Phenotypic Differences between Familial and De Novo CPVT Patient Carrying RYR2 Variants)

  Shimamoto Keiko; Ohno Seiko; Kato Koichi; Takayama Koichiro; Sonoda Keiko; Fukuyama Megumi; Makiyama Takeru; Okamura Satomi; Asakura Koko; Imanishi Noriaki; Kato Yoshiaki; Sakaguchi Heima; Kamakura Tsukasa; Wada Mitsuru; Yamagata Kenichiro; Ishibashi Kohei; Inoue Yuko; Miyamoto Koji; Nagase Satoshi; Kusano Kengo; Horie Minoru; Aiba Takeshi

  日本循環器学会学術集会抄録集, Mar. 2022

  
• RYR2変異を有する遺伝性特発性不整脈症候群患者における重度表現型(Severe Phenotype in RYR2 Variant Carriers with Idiopathic Primary Arrhythmia Syndromes)

  Fukuyama Megumi; Ohno Seiko; Kato Koichi; Fujii Yusuke; Takayama Koichiro; Makiyama Takeru; Horie Minoru; Nakagawa Yoshihisa

  日本循環器学会学術集会抄録集, Jul. 2020

  
• カルシウムハンドリング関連遺伝子に変異を有する先天性QT延長症候群患者の重症度の変化(Variable Severity in Long QT Syndrome Patients with Mutations in Genes Related with Calcium Handling)

  Fukuyama Megumi; Ohno Seiko; Ozawa Junichi; Yamamoto Yuta; Kato Koichi; Takayama Koichiro; Yagi Noriaki; Makiyama Takeru; Horie Minoru; Nakagawa Yoshihisa

  日本循環器学会学術集会抄録集, Jul. 2020

  
• 遺伝性不整脈におけるオーダーメイド医療 NGSに基づくLQTSの遺伝子型分析 微動遺伝子はもはや軽微ではない(Precision Medicine in Inherited Arrhythmias An NGS-based Genotyping in LQTS: Minor Genes are No Longer Minor)

  Ohno Seiko; Ozawa Junichi; Fukuyama Megumi; Makiyama Takeru; Horie Minoru

  日本循環器学会学術集会抄録集, Mar. 2019

  
• 洞不全症候群を伴う遺伝性心臓突然死症候群の新しいメカニズム PITX2-ANK2間の遺伝子間欠失によるクロマチン構造の乱れ(A Novel Mechanism of Inherited Sudden Cardiac Death Syndrome with Sinus Node Dysfunction: Intergenic Deletion between PITX2-ANK2 Disrupts Chromatin Structure)

  村田 広茂; 蒔田 直昌; 牧山 武; 清水 渉

  日本循環器学会学術集会抄録集, Mar. 2022

  
• Calmodulinopathy in Japanese Children - Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy.

  Megumi Fukuyama; Minoru Horie; Koichi Kato; Hisaaki Aoki; Shuhei Fujita; Yoko Yoshida; Hisanori Sakazaki; Takako Toda; Michihiko Ueno; Gaku Izumi; Nobuo Momoi; Jun Muneuchi; Takeru Makiyama; Yoshihisa Nakagawa; Seiko Ohno

  Circulation journal : official journal of the Japanese Circulation Society, 28 Jun. 2023

  
• Targeted deep sequencing analyses of long QT syndrome in a Japanese population.

  Yuki Nagata; Ryo Watanabe; Christian Eichhorn; Seiko Ohno; Takeshi Aiba; Taisuke Ishikawa; Yukiko Nakano; Yoshiyasu Aizawa; Kenshi Hayashi; Nobuyuki Murakoshi; Tadashi Nakajima; Nobue Yagihara; Hiroyuki Mishima; Takeaki Sudo; Chihiro Higuchi; Atsushi Takahashi; Akihiro Sekine; Takeru Makiyama; Yoshihiro Tanaka; Atsuyuki Watanabe; Motomi Tachibana; Hiroshi Morita; Koh-Ichiro Yoshiura; Tatsuhiko Tsunoda; Hiroshi Watanabe; Masahiko Kurabayashi; Akihiko Nogami; Yasuki Kihara; Minoru Horie; Wataru Shimizu; Naomasa Makita; Toshihiro Tanaka

  PloS one, 08 Dec. 2022, Peer-reviewed

  
• Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly.

  Junichi Ozawa; Seiko Ohno; Dario Melgari; Qi Wang; Megumi Fukuyama; Futoshi Toyoda; Takeru Makiyama; Masao Yoshinaga; Hiroshi Suzuki; Akihiko Saitoh; Tomohiko Ai; Minoru Horie

  Scientific reports, 08 Nov. 2022

  
• Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

  Jingshan Gao; Takeru Makiyama; Yuta Yamamoto; Takuya Kobayashi; Hisaaki Aoki; Thomas L Maurissen; Yimin Wuriyanghai; Asami Kashiwa; Tomohiko Imamura; Takanori Aizawa; Hai Huang; Hirohiko Kohjitani; Misato Nishikawa; Kazuhisa Chonabayashi; Megumi Fukuyama; Hiromi Manabe; Kouichi Nakau; Tsutomu Wada; Koichi Kato; Futoshi Toyoda; Yoshinori Yoshida; Naomasa Makita; Knut Woltjen; Seiko Ohno; Nagomi Kurebayashi; Takashi Murayama; Takashi Sakurai; Minoru Horie; Takeshi Kimura

  Circulation. Arrhythmia and electrophysiology, 03 Mar. 2023

  
• Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome.

  Takanori Aizawa; Yuko Wada; Kanae Hasegawa; Hai Huang; Tomohiko Imamura; Jingshan Gao; Asami Kashiwa; Hirohiko Kohjitani; Megumi Fukuyama; Koichi Kato; Eri Toda Kato; Takashi Hisamatsu; Seiko Ohno; Takeru Makiyama; Takeshi Kimura; Minoru Horie

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 02 Mar. 2023

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• 機械学習を用いた遺伝性不整脈疾患の予後予測モデルの開発(Development of a Genetic Prognostic Model for Hereditary Arrhythmia Disease Using Machine Learning)

  Kohjitani Hirohiko; Mitani Takeshi; Aizawa Takanori; Makiyama Takeru; Kashiwa Asami; Imamura Tomohiko; Ohno Seiko; Horie Minoru; Shizuta Satoshi; Kimura Takeshi; Okuno Yasushi

  日本循環器学会学術集会抄録集, Mar. 2022

  
• KCNH2のhaploinsufficient variantとQT延長症候群2型患者における良好な不整脈予後(Haploinsufficient Variant of KCNH2 Cause Better Arrhythmia Outcome in Patients with Type 2 Long QT Syndrome)

  Aizawa Takanori; Wada Yuko; Makiyama Takeru; Huang Hai; Imamura Tomohiko; Gao Jingshan; Kashiwa Asami; Kohjitani Hirohiko; Kato Koichi; Ohno Seiko; Kimura Takeshi; Horie Minoru

  日本循環器学会学術集会抄録集, Mar. 2022

  
• CPVTに関連する新規カルモジュリン変異は変異体CaM-RyR2結合親和性の増加によりiPS細胞モデルでRyR2を介したCa2+リークを引き起こす(A Novel CPVT-associated Calmodulin Mutation Causes Ca2+ Leaks via RyR2 in iPSC Model Due to Increased Mutant CaM-RyR2 Binding Affinity)

  Gao Jingshan; Makiyama Takeru; Yamamoto Yuta; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Kohjitani Hirohiko; Kato Koichi; Ohno Seiko; Horie Minoru; Kimura Takeshi; Aoki Hisaaki; Makita Naomasa

  日本循環器学会学術集会抄録集, Mar. 2022

  
• オリゴヌクレオチドを用いたcalmodulinopathyに対する治療法の開発(Development of an Oligonucleotide-Based Therapeutic Approach for Calmodulinopathy)

  Makiyama Takeru; Yamamoto Yuta; Kondoh Yoshiki; Gao Jingshan; Kashiwa Asami; Aizawa Takanori; Imamura Tomohiko; Huang Hai; Kohjitani Hirohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Makita Naomasa; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2021

  
• 遺伝性不整脈に対するオーダーメイド医療の現在の概観 iPS細胞を用いたリアノジン受容体遺伝子異常による遺伝性不整脈のモデリング(Current Perspective on Precision Medicine of Inherited Arrhythmias Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction Using iPS Cells)

  Makiyama Takeru; Gao Jingshan; Yamamoto Yuta; Kashiwa Asami; Aizawa Takanori; Imamura Tomohiko; Huang Hai; Kohjitani Hirohiko; Kato Kouichi; Ishikawa Taisuke; Aoki Hisaaki; Toyoda Futoshi; Wolten Knut; Yoshida Yoshinori; Ohno Seiko; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2021

  
• CRISPR/Cas9を用いたノックインゲノム編集技術で作製したiPS細胞モデルを用いたRYR2変異によるQT延長症候群のモデル化(Modeling RYR2-related Long-QT Syndrome Using iPS Cell Model Generated by CRISPR/Cas9-based Knock-in Genome Editing Technology)

  Gao Jingshan; Makiyama Takeru; Ohno Seiko; Yamamoto Yuta; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Huang Hai; Kohjitani Hirohiko; Kato Koichi; Toyoda Futoshi; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2021

  
• QT延長症候群に関連するCALM2-N98S変異はヒトiPSC由来心筋細胞におけるβ-アドレナリン刺激に対するKCNQ1チャネルの応答を損なう(CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes)

  Yamamoto Yuta; Makiyama Takeru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Gao Jingshan; Kashiwa Asami; Huang Hai; Aizawa Takanori; Imamura Tomohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Horie Minoru; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• 人工知能による細胞特異的hiPSC-CMsのシミュレーションと薬物試験予測の最適化手法(Artificial Intelligence Based Optimization System for Cell-specific hiPSC-CMs Simulation and Prediction of Drug Testing)

  Kohjitani Hirohiko; Makiyama Takeru; Yamamoto Yuta; Yimin Wuriyanghai; Yoshinaga Daisuke; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Gao Jingshan; Huang Hai; Shizuta Satoshi; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• LMNA関連心筋症に特異的なiPS細胞由来の心筋細胞にアドレナリン作動性刺激を負荷すると、分化早期に加齢関連表現型を繰り返す(LMNA-Related Cardiomyopathy Specific Induced-Pluripotent Stem Cells-derived Cardiomyocytes Stressed by Adrenergic Stimulation Recapitulate the Aging-Related Phenotype in an Early-Phase of Differentiation)

  Nishiuchi Suguru; Makiyama Takeru; Sasaki Kenichi; Kohjitani Hirohiko; Yimin Wuriyanghai; Yamamoto Yuta; Harita Takeshi; Hayano Mamoru; Kamakura Tsukasa; Ohno Seiko; Yoshida Yoshinori; Doi Takahiro; Shizuta Satoshi; Aiba Takeshi; Horie Minoru; Kimura Takeshi

  Circulation Journal, Mar. 2015

  
• Metalloprotease Nardilysin regulates sinus automaticity through transcriptional regulation of ion channels.

  Ohno Mikiko; Nishi Kiyoto; Matsuura Hiroshi; Makiyama Takeru; Koujitani Hirohiko; Matsuda Shintaro; Kimura Takeshi; Nishi Eiichiro

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022

  
• Gradient-based parameter optimization method to determine membrane ionic current composition in human induced pluripotent stem cell-derived cardiomyocytes.

  Hirohiko Kohjitani; Shigeya Koda; Yukiko Himeno; Takeru Makiyama; Yuta Yamamoto; Daisuke Yoshinaga; Yimin Wuriyanghai; Asami Kashiwa; Futoshi Toyoda; Yixin Zhang; Akira Amano; Akinori Noma; Takeshi Kimura

  Scientific reports, 09 Nov. 2022

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• 小児におけるブルガダ症候群の臨床的側面 性別と年齢が予後に与える影響(Clinical Aspects of Brugada Syndrome in Children: The Impact of Gender and Age on the Prognosis)

  今村 知彦; 牧山 武; 小澤 淳一; 相澤 卓範; 柏 麻美; 糀谷 泰彦; 加藤 浩一; 青木 寿明; 鈴木 博; 園田 桂子; 大野 聖子; 住友 直方; 堀江 稔; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2022

  
• ヒトiPS細胞モデルを用いた遺伝性不整脈疾患の基礎研究 診断、発症機序解明、新規治療法開発

  牧山 武; 山本 雄大; 吉永 大介; 廣瀬 紗也子; 相澤 卓範; 柏 麻美; 高 景山; 今村 知彦; 黄 海; 糀谷 泰彦; 大野 聖子; 蒔田 直昌; 堀江 稔; 木村 剛

  循環器内科, Oct. 2021

  
• 日本人レジストリに登録された小児ブルガダ症候群の臨床的特徴(Clinical Characteristics of Pediatric Brugada Syndrome in Japanese Registry)

  今村 知彦; 牧山 武; 小澤 淳一; 相澤 卓範; 柏 麻美; 山本 雄大; 糀谷 泰彦; 加藤 浩一; 青木 寿明; 大野 聖子; 鈴木 博; 住友 直方; 吉永 正夫; 堀江 稔; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2021

  
• 心筋L型カルシウムチャネルのイオン選択性を阻害するCACNA1C-E1115KのヒトiPS細胞モデル(Human Induced Pluripotent Stem Cell Model of CACNA1C-E1115K which Impairs Ion Selectivity of the Cardiac L-type Calcium Channel)

  柏 麻美; 牧山 武; Maurissen Thomas; 糀谷 泰彦; Wuriyanghai Yimin; 山本 雄大; Gao Jingshan; Huang Hai; 今村 知彦; 相澤 卓範; 石川 泰輔; 大野 聖子; 豊田 太; 佐藤 誠一; 高橋 一浩; Woltjen Knut; 堀江 稔; 蒔田 直昌; 木村 剛

  日本循環器学会学術集会抄録集, Jul. 2020

  
• 複雑な疾患メカニズムの解明における数理モデルとiPS細胞を利用した細胞工学を組み合わせた技術の有用性(Usefulness of Combination of Mathematical Modeling and Cell Engineering Using Induced Pluripotent Stem Cells for Revealing Complex Disease Mechanism)

  糀谷 泰彦; 柏 麻美; 野間 昭典; 牧山 武; 豊田 太; 山本 雄大; 烏日揚海 伊敏; 堀江 稔; 大野 聖子; 高 景山; 黄 海; 今村 知彦; 相澤 卓範; 静田 聡; 木村 剛

  日本循環器学会学術集会抄録集, Jul. 2020

  
• Disrupted Cav1.2 Selectivity Causes Overlapping Long QT and Brugada Syndrome Phenotypes in CACNA1C-E1115K iPS Cell Model.

  Asami Kashiwa; Takeru Makiyama; Hirohiko Kohjitani; Thomas L Maurissen; Taisuke Ishikawa; Yuta Yamamoto; Yimin Wuriyanghai; Jingshan Gao; Hai Huang; Tomohiko Imamura; Takanori Aizawa; Misato Nishikawa; Kazuhisa Chonabayashi; Hiroyuki Mishima; Seiko Ohno; Futoshi Toyoda; Seiichi Sato; Koh-Ichiro Yoshiura; Kazuhiro Takahashi; Yoshinori Yoshida; Knut Woltjen; Minoru Horie; Naomasa Makita; Takeshi Kimura

  Heart rhythm, 22 Aug. 2022

  
• A Novel Mechanism of Inherited Sudden Cardiac Death Syndrome with Sinus Node Dysfunction: Intergenic Deletion between PITX2-ANK2 Disrupts Chromatin Structure(和訳中)

  村田 広茂; 蒔田 直昌; 牧山 武; 清水 渉

  日本循環器学会学術集会抄録集, Mar. 2022

  
• Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome.

  Sayako Hirose; Takashi Murayama; Naoyuki Tetsuo; Minako Hoshiai; Hiroaki Kise; Masao Yoshinaga; Hisaaki Aoki; Megumi Fukuyama; Yimin Wuriyanghai; Yuko Wada; Koichi Kato; Takeru Makiyama; Takeshi Kimura; Takashi Sakurai; Minoru Horie; Nagomi Kurebayashi; Seiko Ohno

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 02 Mar. 2022

  
• Association Between Deleterious SCN5A Variants and Ventricular Septal Defect in Young Patients With Brugada Syndrome.

  Keisuke Suzuki; Keiko Sonoda; Hisaaki Aoki; Yuko Nakamura; Seiichi Watanabe; Yoko Yoshida; Kenji Hoshino; Junichi Ozawa; Tomohiko Imamura; Takeshi Aiba; Koichi Kato; Takeru Makiyama; Kengo Kusano; Minoru Horie; Seiko Ohno

  JACC. Clinical electrophysiology, Mar. 2022

  
• Impact of cascade screening for catecholaminergic polymorphic ventricular tachycardia type 1.

  Keiko Shimamoto; Seiko Ohno; Koichi Kato; Koichiro Takayama; Keiko Sonoda; Megumi Fukuyama; Takeru Makiyama; Satomi Okamura; Koko Asakura; Noriaki Imanishi; Yoshiaki Kato; Heima Sakaguchi; Tsukasa Kamakura; Mitsuru Wada; Kenichiro Yamagata; Kohei Ishibashi; Yuko Inoue; Koji Miyamoto; Satoshi Nagase; Kengo Kusano; Minoru Horie; Takeshi Aiba

  Heart (British Cardiac Society), 08 Feb. 2022

  
• School-based routine screenings of electrocardiograms for the diagnosis of long QT syndrome.

  Megumi Fukuyama; Minoru Horie; Hisaaki Aoki; Junichi Ozawa; Koichi Kato; Yuichi Sawayama; Sachiko Tanaka-Mizuno; Takeru Makiyama; Masao Yoshinaga; Yoshihisa Nakagawa; Seiko Ohno

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 21 Jan. 2022

  
• Oral Adrenergic Agents Produced Ventricular Fibrillation and QT Prolongation in an Elderly Patient Carrying an RYR2 Variant.

  Kanae Hasegawa; Jingshan Gao; Seiko Ohno; Kentaro Ishida; Shinsuke Miyazaki; Takeru Makiyama; Minoru Horie; Hiroyasu Uzui; Hiroshi Tada

  International heart journal, 2022

  
• Pueraria mirifica, an estrogenic tropical herb, unveiled the severity of Type 1 LQTS caused by KCNQ1-T587M.

  Asami Kashiwa; Yukio Hosaka; Kazuyoshi Takahashi; Seiko Ohno; Yuko Wada; Takeru Makiyama; Hirotaka Oda; Minoru Horie

  Journal of arrhythmia, Aug. 2021

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• Corrigendum to "A challenge for mutation specific risk stratification in long QT syndrome type 1" [J. Cardiol. 72(1) (2018) 56-65].

  Noriaki Yagi; Hideki Itoh; Takashi Hisamatsu; Yukinori Tomita; Hiromi Kimura; Yusuke Fujii; Takeru Makiyama; Minoru Horie; Seiko Ohno

  Journal of cardiology, Mar. 2021

  
• iPS細胞モデルを用いたQT延長症候群に対する新規Ca2+チャネル抑制メカニズムによる治療法開発

  牧山 武; 張田 健志; 山本 雄大; 横井 文香; 豊田 太; 大野 聖子; 木村 剛; 堀江 稔

  臨床薬理の進歩, Jun. 2020

  
• Genetic Background of Catecholaminergic Polymorphic Ventricular Tachycardia in Japan.

  Mihoko Kawamura; Seiko Ohno; Nobu Naiki; Iori Nagaoka; Kenichi Dochi; Qi Wang; Kanae Hasegawa; Hiromi Kimura; Akashi Miyamoto; Yuka Mizusawa; Hideki Itoh; Takeru Makiyama; Naokata Sumitomo; Hiroya Ushinohama; Kotaro Oyama; Nobuyuki Murakoshi; Kazutaka Aonuma; Hitoshi Horigome; Takafumi Honda; Masao Yoshinaga; Makoto Ito; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, 2020

  
• Clinical characteristics and outcomes of patients with venous thromboembolism according to diagnosis on weekends versus on weekdays.

  Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Yusuke Morita; Tomohisa Tada; Toshiaki Izumi; Po-Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Yuji Nishimoto; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  Journal of thrombosis and thrombolysis, Apr. 2021

  
• Impact of no, distal, and proximal deep vein thrombosis on clinical outcomes in patients with acute pulmonary embolism: From the COMMAND VTE registry.

  Shushi Nishiwaki; Yusuke Morita; Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po-Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Moriaki Inoko; Takeshi Kimura

  Journal of cardiology, Apr. 2021

  
• Overview of the 84th Annual Scientific Meeting of the Japanese Circulation Society -Change Practice!-

  Koh Ono; Satoshi Shizuta; Erika Yamamoto; Naritatsu Saito; Neiko Ozasa; Takao Kato; Eri Kato; Takahiro Horie; Junichi Tazaki; Hiroki Shiomi; Shin Watanabe; Hirotoshi Watanabe; Yugo Yamashita; Yusuke Yoshikawa; Hideyuki Kinoshita; Takeru Makiyama; Yoshinori Yoshida; Noboru Ashida; Yasuaki Nakagawa; Yasuhiro Nakashima; Osamu Baba; Hirohiko Kohjitani; Masahiro Kimura; Hideaki Inazumi; Takashi Yoshizawa; Akihiro Komasa; Takeshi Kimura

  CIRCULATION JOURNAL, Mar. 2021

  
• Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children.

  Tomohiko Imamura; Naokata Sumitomo; Shota Muraji; Kazushi Yasuda; Eiki Nishihara; Mari Iwamoto; Shigeru Tateno; Shozaburo Doi; Tadayoshi Hata; Shigetoyo Kogaki; Hitoshi Horigome; Seiko Ohno; Fukiko Ichida; Masami Nagashima; Takeru Makiyama; Masao Yoshinaga

  International journal of cardiology, 15 Jan. 2021

  
• Risk Factors for Major Bleeding During Anticoagulation Therapy in Cancer-Associated Venous Thromboembolism - From the COMMAND VTE Registry.

  Yuji Nishimoto; Yugo Yamashita; Kitae Kim; Takeshi Morimoto; Syunsuke Saga; Hidewo Amano; Toru Takase; Seiichi Hiramori; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po-Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Yukihito Sato; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 23 Oct. 2020

  
• LMNA Missense Mutation Causes Nonsense-Mediated mRNA Decay and Severe Dilated Cardiomyopathy.

  Koichi Kato; Seiko Ohno; Keiko Sonoda; Megumi Fukuyama; Takeru Makiyama; Tomoya Ozawa; Minoru Horie

  Circulation. Genomic and precision medicine, Oct. 2020

  
• Systematic Evaluation of KCNQ1 Variant Using ACMG/AMP Guidelines and Risk Stratification in Long QT Syndrome Type 1.

  Asami Kashiwa; Takeshi Aiba; Hisaki Makimoto; Keiko Shimamoto; Kenichiro Yamagata; Tsukasa Kamakura; Mitsuru Wada; Koji Miyamoto; Yuko Inoue-Yamada; Kohei Ishibashi; Takashi Noda; Satoshi Nagase; Aya Miyazaki; Heima Sakaguchi; Isao Shiraishi; Nobue Yagihara; Hiroshi Watanabe; Yoshifusa Aizawa; Takeru Makiyama; Hideki Itoh; Kenshi Hayashi; Masakazu Yamagishi; Naotaka Sumitomo; Masao Yoshinaga; Hiroshi Morita; Tohru Ohe; Yoshihiro Miyamoto; Naomasa Makita; Satoshi Yasuda; Kengo Kusano; Seiko Ohno; Minoru Horie; Wataru Shimizu

  Circulation. Genomic and precision medicine, 16 Sep. 2020

  
• Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

  Roddy Walsh; Najim Lahrouchi; Rafik Tadros; Florence Kyndt; Charlotte Glinge; Pieter G. Postema; Ahmad S. Amin; Eline A. Nannenberg; James S. Ware; Nicola Whiffin; Francesco Mazzarotto; Doris Škorić-Milosavljević; Christian Krijger; Elena Arbelo; Dominique Babuty; Hector Barajas-Martinez; Britt M. Beckmann; Stéphane Bézieau; J. Martijn Bos; Jeroen Breckpot; Oscar Campuzano; Silvia Castelletti; Candan Celen; Sebastian Clauss; Anniek Corveleyn; Lia Crotti; Federica Dagradi; Carlo de Asmundis; Isabelle Denjoy; Sven Dittmann; Patrick T. Ellinor; Cristina Gil Ortuño; Carla Giustetto; Jean-Baptiste Gourraud; Daisuke Hazeki; Minoru Horie; Taisuke Ishikawa; Hideki Itoh; Yoshiaki Kaneko; Jørgen K. Kanters; Hiroki Kimoto; Maria-Christina Kotta; Ingrid P. C. Krapels; Masahiko Kurabayashi; Julieta Lazarte; Antoine Leenhardt; Bart L. Loeys; Catarina Lundin; Takeru Makiyama; Jacques Mansourati; Raphaël P. Martins; Andrea Mazzanti; Stellan Mörner; Carlo Napolitano; Kimie Ohkubo; Michael Papadakis; Boris Rudic; Maria Sabater Molina; Frédéric Sacher; Hatice Sahin; Georgia Sarquella-Brugada; Regina Sebastiano; Sanjay Sharma; Mary N. Sheppard; Keiko Shimamoto; M. Benjamin Shoemaker; Birgit Stallmeyer; Johannes Steinfurt; Yuji Tanaka; David J. Tester; Keisuke Usuda; Paul A. van der Zwaag; Sonia Van Dooren; Lut Van Laer; Annika Winbo; Bo G. Winkel; Kenichiro Yamagata; Sven Zumhagen; Paul G. A. Volders; Steven A. Lubitz; Charles Antzelevitch; Pyotr G. Platonov; Katja E. Odening; Dan M. Roden; Jason D. Roberts; Jonathan R. Skinner; Jacob Tfelt-Hansen; Maarten P. van den Berg; Morten S. Olesen; Pier D. Lambiase; Martin Borggrefe; Kenshi Hayashi; Annika Rydberg; Tadashi Nakajima; Masao Yoshinaga; Johan B. Saenen; Stefan Kääb; Pedro Brugada; Tomas Robyns; Daniela F. Giachino; Michael J. Ackerman; Ramon Brugada; Josep Brugada; Juan R. Gimeno; Can Hasdemir; Pascale Guicheney; Silvia G. Priori; Eric Schulze-Bahr; Naomasa Makita; Peter J. Schwartz; Wataru Shimizu; Takeshi Aiba; Jean-Jacques Schott; Richard Redon; Seiko Ohno; Vincent Probst; Elijah R. Behr; Julien Barc; Connie R. Bezzina

  Genetics in Medicine, 07 Sep. 2020

  
• Telethonin variants found in Brugada syndrome, J-wave pattern ECG, and ARVC reduce peak Nav1.5 currents in HEK-293 cells

  Isik Turker; Takeru Makiyama; Takeshi Ueyama; Akihiko Shimizu; Masaru Yamakawa; Peng Sheng Chen; Matteo Vatta; Minoru Horie; Tomohiko Ai

  PACE - Pacing and Clinical Electrophysiology, 01 Aug. 2020

  
• Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

  Najim Lahrouchi; Rafik Tadros; Lia Crotti; Yuka Mizusawa; Pieter G. Postema; Leander Beekman; Roddy Walsh; Kanae Hasegawa; Julien Barc; Marko Ernsting; Kari L. Turkowski; Andrea Mazzanti; Britt M. Beckmann; Keiko Shimamoto; Ulla-Britt Diamant; Yanushi D. Wijeyeratne; Yu Kucho; Tomas Robyns; Taisuke Ishikawa; Elena Arbelo; Michael Christiansen; Annika Winbo; Reza Jabbari; Steven A. Lubitz; Johannes Steinfurt; Boris Rudic; Bart Loeys; M. Ben Shoemaker; Peter E. Weeke; Ryan Pfeiffer; Brianna Davies; Antoine Andorin; Nynke Hofman; Federica Dagradi; Matteo Pedrazzini; David J. Tester; J. Martijn Bos; Georgia Sarquella-Brugada; Óscar Campuzano; Pyotr G. Platonov; Birgit Stallmeyer; Sven Zumhagen; Eline A. Nannenberg; Jan H. Veldink; Leonard H. van den Berg; Ammar Al-Chalabi; Christopher E. Shaw; Pamela J. Shaw; Karen E. Morrison; Peter M. Andersen; Martina Müller-Nurasyid; Daniele Cusi; Cristina Barlassina; Pilar Galan; Mark Lathrop; Markus Munter; Thomas Werge; Marta Ribasés; Tin Aung; Chiea C. Khor; Mineo Ozaki; Peter Lichtner; Thomas Meitinger; J. Peter van Tintelen; Yvonne Hoedemaekers; Isabelle Denjoy; Antoine Leenhardt; Carlo Napolitano; Wataru Shimizu; Jean-Jacques Schott; Jean-Baptiste Gourraud; Takeru Makiyama; Seiko Ohno; Hideki Itoh; Andrew D. Krahn; Charles Antzelevitch; Dan M. Roden; Johan Saenen; Martin Borggrefe; Katja E. Odening; Patrick T. Ellinor; Jacob Tfelt-Hansen; Jonathan R. Skinner; Maarten P. van den Berg; Morten Salling Olesen; Josep Brugada; Ramón Brugada; Naomasa Makita; Jeroen Breckpot; Masao Yoshinaga; Elijah R. Behr; Annika Rydberg; Takeshi Aiba; Stefan Kääb; Silvia G. Priori; Pascale Guicheney; Hanno L. Tan; Christopher Newton-Cheh; Michael J. Ackerman; Peter J. Schwartz; Eric Schulze-Bahr; Vincent Probst; Minoru Horie; Arthur A. Wilde; Michael W.T. Tanck; Connie R. Bezzina

  Circulation, 28 Jul. 2020, Peer-reviewed

  
• An NGS-based genotyping in LQTS; minor genes are no longer minor.

  Seiko Ohno; Junichi Ozawa; Megumi Fukuyama; Takeru Makiyama; Minoru Horie

  Journal of human genetics, 17 Jul. 2020, Peer-reviewed

  
• CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes(和訳中)

  Yamamoto Yuta; Makiyama Takeru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Gao Jingshan; Kashiwa Asami; Huang Hai; Aizawa Takanori; Imamura Tomohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Horie Minoru; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• Artificial Intelligence Based Optimization System for Cell-specific hiPSC-CMs Simulation and Prediction of Drug Testing(和訳中)

  Kohjitani Hirohiko; Makiyama Takeru; Yamamoto Yuta; Yimin Wuriyanghai; Yoshinaga Daisuke; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Gao Jingshan; Huang Hai; Shizuta Satoshi; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• Human Induced Pluripotent Stem Cell Model of CACNA1C-E1115K which Impairs Ion Selectivity of the Cardiac L-type Calcium Channel(和訳中)

  柏 麻美; 牧山 武; Maurissen Thomas; 糀谷 泰彦; Wuriyanghai Yimin; 山本 雄大; Gao Jingshan; Huang Hai; 今村 知彦; 相澤 卓範; 石川 泰輔; 大野 聖子; 豊田 太; 佐藤 誠一; 高橋 一浩; Woltjen Knut; 堀江 稔; 蒔田 直昌; 木村 剛

  日本循環器学会学術集会抄録集, Jul. 2020

  
• Usefulness of Combination of Mathematical Modeling and Cell Engineering Using Induced Pluripotent Stem Cells for Revealing Complex Disease Mechanism(和訳中)

  糀谷 泰彦; 柏 麻美; 野間 昭典; 牧山 武; 豊田 太; 山本 雄大; 烏日揚海 伊敏; 堀江 稔; 大野 聖子; 高 景山; 黄 海; 今村 知彦; 相澤 卓範; 静田 聡; 木村 剛

  日本循環器学会学術集会抄録集, Jul. 2020

  
• Predictive ability of modified Ottawa score for recurrence in patients with cancer-associated venous thromboembolism: From the COMMAND VTE Registry.

  Yuji Nishimoto; Yugo Yamashita; Takeshi Morimoto; Syunsuke Saga; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po-Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Yukihito Sato; Takeshi Kimura

  Thrombosis research, Jul. 2020

  
• iPS細胞モデルを用いたQT延長症候群に対する新規Ca2+チャネル抑制メカニズムによる治療法開発

  牧山 武; 張田 健志; 山本 雄大; 横井 文香; 豊田 太; 大野 聖子; 木村 剛; 堀江 稔

  臨床薬理の進歩, Jun. 2020

  
• SCN5A mutation identified in a patient with short-coupled variant of torsades de pointes.

  Keiko Sonoda; Seiko Ohno; Yukiko Shimizu; Kazuaki Kaitani; Takeru Makiyama; Yoshihisa Nakagawa; Minoru Horie

  Pacing and clinical electrophysiology : PACE, May 2020, Peer-reviewed

  
• High Prevalence of Late-Appearing T-Wave in Patients With Long QT Syndrome Type 8

  Megumi Fukuyama; Seiko Ohno; Junichi Ozawa; Koichi Kato; Takeru Makiyama; Yoshihisa Nakagawa; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, 25 Mar. 2020, Peer-reviewed

  
• ヒト多能性幹細胞由来心筋細胞のシミュレーションモデル開発によるペースメーカー機転の多重メカニズム解析(Multi-layer Cardiac Pacemaker Mechanisms demonstrated in Human Induced Pluripotent Stem Cells by Developing Mathematical Cell Models)

  Kohjitani Hirohiko; Koda Shigeya; Himeno Yukiko; Makiyama Takeru; Yamamoto Yuta; Wuriyanghai Yimin; Yoshinaga Daisuke; Kashiwa Asami; Amano Akira; Noma Akinori; Kimura Takeshi

  The Journal of Physiological Sciences, Mar. 2020

  
• 患者由来iPS細胞モデルを用いたCav 1.2イオン選択性を障害するCACNA1C-E1115K変異がQT延長症候群、Brugada症候群を発症するメカニズムの解析(CACNA1C-E1115K Mutation Associated with Overlap Phenotype of Long-QT and Brugada Syndrome Disrupts Cav 1.2 Ion Selectivity in Patient-specific iPS Cell-derived Cardiomyocytes)

  Kashiwa Asami; Makiyama Takeru; Kohjitani Hirohiko; Maurissen Thomas; Wuriyanghai Yimin; Yamamoto Yuta; Gao Jingshan; Huang Hai; Imamura Tomohiko; Aizawa Takanori; Ishikawa Taisuke; Ohno Seiko; Toyoda Futoshi; Sato Seiich; Takahashi Kazuhiro; Woltjen Knut; Horie Minoru; Makita Naomasa; Kimura Takeshi

  The Journal of Physiological Sciences, Mar. 2020

  
• Usefulness of Simplified Pulmonary Embolism Severity Index Score for Identification of Patients With Low-Risk Pulmonary Embolism and Active Cancer: From the COMMAND VTE Registry

  Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Yuji Nishimoto; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  Chest, Mar. 2020, Peer-reviewed

  
• Validation of the VTE-BLEED score’s long-term performance for major bleeding in patients with venous thromboembolisms: From the COMMAND VTE registry

  Yuji Nishimoto; Yugo Yamashita; Takeshi Morimoto; Syunsuke Saga; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Yukihito Sato; Takeshi Kimura; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi

  Journal of Thrombosis and Haemostasis, 01 Mar. 2020, Peer-reviewed

  
• Effect of Statins on Recurrent Venous Thromboembolism (from the COMMAND VTE Registry)

  Yusuke Yoshikawa; Yugo Yamashita; Takeshi Morimoto; Hiroshi Mabuchi; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Yuji Nishimoto; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Tomoyuki Murakami; Takeshi Kimura

  American Journal of Cardiology, 15 Jan. 2020, Peer-reviewed

  
• Age-Dependent Clinical and Genetic Characteristics in Japanese Patients with Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia.

  Seiko Ohno; Iori Nagaoka; Megumi Fukuyama; Hiromi Kimura; Hideki Itoh; Takeru Makiyama; Akihiko Shimizu; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, 2020

  
• Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model.

  Sayako Hirose; Takeru Makiyama; Dario Melgari; Yuta Yamamoto; Yimin Wuriyanghai; Fumika Yokoi; Suguru Nishiuchi; Takeshi Harita; Mamoru Hayano; Hirohiko Kohjitani; Jingshan Gao; Asami Kashiwa; Misato Nishikawa; Jie Wu; Jun Yoshimoto; Kazuhisa Chonabayashi; Seiko Ohno; Yoshinori Yoshida; Minoru Horie; Takeshi Kimura

  Frontiers in cell and developmental biology, 2020

  
• Erratum: Optical recording of action potentials in human induced pluripotent stem cell-derived cardiac single cells and monolayers generated from long qt syndrome type 1 patients (Stem Cells International (2019) 2019 (7532657) DOI: 10.1155/2019/7532657)

  Tadashi Takaki; Azusa Inagaki; Kazuhisa Chonabayashi; Keiji Inoue; Kenji Miki; Seiko Ohno; Takeru Makiyama; Minoru Horie; Yoshinori Yoshida

  Stem Cells International, 2020, Peer-reviewed

  
• Clinical outcomes of patients with pulmonary embolism versus deep vein thrombosis: From the COMMAND VTE Registry

  Yugo Yamashita; Koichiro Murata; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Yoshiaki Tsuyuki; Syunsuke Saga; Yuji Nishimoto; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Ryuzo Nawada; Tomoya Onodera; Takeshi Kimura

  Thrombosis Research, Dec. 2019, Peer-reviewed

  
• A de novo gain-of-function KCND3 mutation in early repolarization syndrome

  Koichiro Takayama; Seiko Ohno; Wei Guang Ding; Takashi Ashihara; Daisuke Fukumoto; Yuko Wada; Takeru Makiyama; Hiroaki Kise; Minako Hoshiai; Hiroshi Matsuura; Minoru Horie

  Heart Rhythm, Nov. 2019, Peer-reviewed

  
• Thrombolysis with tissue plasminogen activator in patients with acute pulmonary embolisms in the real world: from the COMMAND VTE registry

  Yuji Nishimoto; Yugo Yamashita; Takeshi Morimoto; Syunsuke Saga; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Yukihito Sato; Takeshi Kimura

  Journal of Thrombosis and Thrombolysis, 01 Nov. 2019, Peer-reviewed

  
• Utility of simplified PESI score for identification of low-risk pulmonary embolism patients with active cancer: From the COMMAND VTE Registry.

  Yamashita Y; Morimoto T; Amano H; Takase T; Hiramori S; Kim K; Oi M; Akao M; Kobayashi Y; Toyofuku M; Izumi T; Tada T; Chen PM; Murata K; Tsuyuki Y; Nishimoto Y; Saga S; Sasa T; Sakamoto J; Kinoshita M; Togi K; Mabuchi H; Takabayashi K; Yoshikawa Y; Shiomi H; Kato T; Makiyama T; Ono K; Kimura T; COMMAND VTE Registry Investigators

  Chest, Oct. 2019, Peer-reviewed

  
• The association of recurrence and bleeding events with mortality after venous thromboembolism: From the COMMAND VTE Registry

  Yugo Yamashita; Yusuke Yoshikawa; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  International Journal of Cardiology, 01 Oct. 2019, Peer-reviewed

  
• Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells

  Daisuke Yoshinaga; S. Baba; Takeru Makiyama; Hirofumi Shibata; Takuya Hirata; Kentaro Akagi; Koichi Matsuda; Hirohiko Kohjitani; Y. Wuriyanghai; Katsutsugu Umeda; Yuta Yamamoto; Bruce R. Conklin; Minoru Horie; J. Takita; Toshio Heike

  Stem Cell Reports, 13 Aug. 2019, Peer-reviewed

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• More- Versus Less-Intensive Lipid-Lowering Therapy: Systematic Review and Meta-Analysis

  Toshiaki Toyota; Takeshi Morimoto; Yugo Yamashita; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Yasuaki Nakagawa; Naritatsu Saito; Satoshi Shizuta; Koh Ono; Takeshi Kimura

  Circulation: Cardiovascular Quality and Outcomes, 01 Aug. 2019, Peer-reviewed

  
• Deep vein thrombosis in upper extremities: Clinical characteristics, management strategies and long-term outcomes from the COMMAND VTE Registry

  Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Yuji Nishimoto; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  Thrombosis Research, May 2019, Peer-reviewed

  
• Risk factors for post-thrombotic syndrome in patients with deep vein thrombosis: from the COMMAND VTE registry

  Yuji Nishimoto; Yugo Yamashita; Takeshi Morimoto; Syunsuke Saga; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Yukihito Sato; Takeshi Kimura

  Heart and Vessels, Apr. 2019, Peer-reviewed

  
• Influence of baseline anemia on long-term clinical outcomes in patients with venous thromboembolism: from the COMMAND VTE registry

  Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  Journal of Thrombosis and Thrombolysis, Apr. 2019, Peer-reviewed

  
• Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation

  Noriaki Yamada; Yoshihiro Asano; Masashi Fujita; Satoru Yamazaki; Atsushi Inanobe; Norio Matsuura; Hatasu Kobayashi; Seiko Ohno; Yusuke Ebana; Osamu Tsukamoto; Saki Ishino; Ayako Takuwa; Hidetaka Kioka; Toru Yamashita; Norio Hashimoto; Dimitar P. Zankov; Akio Shimizu; Masanori Asakura; Hiroshi Asanuma; Hisakazu Kato; Yuya Nishida; Yohei Miyashita; Haruki Shinomiya; Nobu Naiki; Kenshi Hayashi; Takeru Makiyama; Hisakazu Ogita; Katsuyuki Miura; Hirotsugu Ueshima; Issei Komuro; Masakazu Yamagishi; Minoru Horie; Koichi Kawakami; Tetsushi Furukawa; Akio Koizumi; Yoshihisa Kurachi; Yasushi Sakata; Tetsuo Minamino; Masafumi Kitakaze; Seiji Takashima

  Circulation, Apr. 2019, Peer-reviewed

  
• Brugada症候群患者におけるSCN5A変異と関連する重複した表現型の洞不全症候群(Overlapping Sick Sinus Syndrome Associated with SCN5A Mutations in Patients with Brugada Syndrome)

  Kashiwa Asami; Makiyama Takeru; Ohno Seiko; Yamamoto Yuta; Kohjitani Hirohiko; Gao Jingshan; Kato Koichi; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2019

  
• Catecholamine誘発性多形性心室頻脈に関連した変異ryanodine受容体2型チャネルの3D構造解析(Three-dimensional Structural Analysis of Mutant Ryanodine Receptor Type 2 Channels Associated with Catecholaminergic Polymorphic Ventricular Tachycardia)

  Gao Jingshan; Makiyama Takeru; Ohno Seiko; Yamamoto Yuta; Wuriyanghai Yimin; Kohjitani Hirohiko; Kashiwa Asami; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2019

  
• Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome with Life-Threatening Arrhythmias in Japanese Patients

  Wataru Shimizu; Hisaki Makimoto; Kenichiro Yamagata; Tsukasa Kamakura; Mitsuru Wada; Koji Miyamoto; Yuko Inoue-Yamada; Hideo Okamura; Kohei Ishibashi; Takashi Noda; Satoshi Nagase; Aya Miyazaki; Heima Sakaguchi; Isao Shiraishi; Takeru Makiyama; Seiko Ohno; Hideki Itoh; Hiroshi Watanabe; Kenshi Hayashi; Masakazu Yamagishi; Hiroshi Morita; Masao Yoshinaga; Yoshiyasu Aizawa; Kengo Kusano; Yoshihiro Miyamoto; Shiro Kamakura; Satoshi Yasuda; Hisao Ogawa; Toshihiro Tanaka; Naotaka Sumitomo; Nobuhisa Hagiwara; Keiichi Fukuda; Satoshi Ogawa; Yoshifusa Aizawa; Naomasa Makita; Tohru Ohe; Minoru Horie; Takeshi Aiba

  JAMA Cardiology, Mar. 2019, Peer-reviewed

  
• Cancer-associated venous thromboembolism in the real world ― from the Command VTE registry ―

  Jiro Sakamoto; Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Yuji Nishimoto; Tomoki Sasa; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Yusuke Yoshikawa; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Toshihiro Tamura; Yoshihisa Nakagawa; Takeshi Kimura

  Circulation Journal, 2019, Peer-reviewed

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• D-dimer levels at diagnosis and long-term clinical outcomes in venous thromboembolism: from the COMMAND VTE Registry

  Maki Oi; Yugo Yamashita; Mamoru Toyofuku; Takeshi Morimoto; Yasuyo Motohashi; Takashi Tamura; Kazuaki Kaitani; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Masaharu Akao; Yohei Kobayashi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  Journal of Thrombosis and Thrombolysis, 2019, Peer-reviewed

  
• Sex differences in clinical characteristics and outcomes of patients with venous thromboembolism: From the COMMAND VTE registry

  Yusuke Yoshikawa; Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  Circulation Journal, 2019, Peer-reviewed

  
• Risk Factors for Major Bleeding during Prolonged Anticoagulation Therapy in Patients with Venous Thromboembolism: From the COMMAND VTE Registry

  Kitae Kim; Yugo Yamashita; Takeshi Morimoto; Takeshi Kitai; Takafumi Yamane; Natsuhiko Ehara; Makoto Kinoshita; Shuichiro Kaji; Hidewo Amano; Toru Takase; Seiichi Hiramori; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Yutaka Furukawa; Takeshi Kimura

  Thrombosis and Haemostasis, 2019, Peer-reviewed

  
• Clinical characteristics and outcomes of venous thromboembolisms according to an out-of-hospital vs. In-hospital onset ― From the COMMAND VTE registry ―

  Yuji Nishimoto; Yugo Yamashita; Takeshi Morimoto; Syunsuke Saga; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Yukihito Sato; Takeshi Kimura

  Circulation Journal, 2019, Peer-reviewed

  
• Optical recording of action potentials in human induced pluripotent stem cell-derived cardiac single cells and monolayers generated from long QT syndrome type 1 patients

  Tadashi Takaki; Azusa Inagaki; Kazuhisa Chonabayashi; Keiji Inoue; Kenji Miki; Seiko Ohno; Takeru Makiyama; Minoru Horie; Yoshinori Yoshida

  Stem Cells International, 2019, Peer-reviewed

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• Influence of Baseline Platelet Count on Outcomes in Patients With Venous Thromboembolism (from the COMMAND VTE Registry)

  Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hirotoshi Watanabe; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  American Journal of Cardiology, 15 Dec. 2018, Peer-reviewed

  
• A hERG mutation E1039X produced a synergistic lesion on i Ks together with KCNQ1-R174C mutation in a LQTS family with three compound mutations

  Jie Wu; Yuka Mizusawa; Seiko Ohno; Wei Guang Ding; Takashi Higaki; Qi Wang; Hirohiko Kohjitani; Takeru Makiyama; Hideki Itoh; Futoshi Toyoda; Andrew F. James; Jules C. Hancox; Hiroshi Matsuura; Minoru Horie

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

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• Complex aberrant splicing in the induced pluripotent stem cell–derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation

  Yimin Wuriyanghai; Takeru Makiyama; Kenichi Sasaki; Tsukasa Kamakura; Yuta Yamamoto; Mamoru Hayano; Takeshi Harita; Suguru Nishiuchi; Jiarong Chen; Hirohiko Kohjitani; Sayako Hirose; Fumika Yokoi; Jingshan Gao; Kazuhisa Chonabayashi; Ken Watanabe; Seiko Ohno; Yoshinori Yoshida; Takeshi Kimura; Minoru Horie

  Heart Rhythm, Oct. 2018, Peer-reviewed

  
• Validation of simplified PESI score for identification of low-risk patients with pulmonary embolism: From the COMMAND VTE Registry.

  Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Maki Oi; Masaharu Akao; Yohei Kobayashi; Mamoru Toyofuku; Toshiaki Izumi; Tomohisa Tada; Po-Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Minako Kinoshita; Kiyonori Togi; Hiroshi Mabuchi; Kensuke Takabayashi; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Koh Ono; Takeshi Kimura

  European heart journal. Acute cardiovascular care, 11 Sep. 2018, Peer-reviewed

  
• Copy number variations of SCN5A in Brugada syndrome

  Keiko Sonoda; Seiko Ohno; Junichi Ozawa; Mamoru Hayano; Tetsuhisa Hattori; Atsushi Kobori; Mitsuhiko Yahata; Isao Aburadani; Seiichi Watanabe; Yuichi Matsumoto; Takeru Makiyama; Minoru Horie

  Heart Rhythm, Aug. 2018, Peer-reviewed

  
• A challenge for mutation specific risk stratification in long QT syndrome type 1

  Noriaki Yagi; Hideki Itoh; Takashi Hisamatsu; Yukinori Tomita; Hiromi Kimura; Yusuke Fujii; Takeru Makiyama; Minoru Horie; Seiko Ohno

  Journal of Cardiology, Jul. 2018, Peer-reviewed

  
• Asian patients versus non-Asian patients in the efficacy and safety of direct oral anticoagulants relative to vitamin K antagonist for venous thromboembolism: A systemic review and meta-analysis

  Yugo Yamashita; Takeshi Morimoto; Toshiaki Toyota; Hiroki Shiomi; Takeru Makiyama; Koh Ono; Takeshi Kimura

  Thrombosis Research, Jun. 2018, Peer-reviewed

  
• Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome

  Daisuke Fukumoto; Wei Guang Ding; Yuko Wada; Yusuke Fujii; Mari Ichikawa; Koichiro Takayama; Megumi Fukuyama; Koichi Kato; Hideki Itoh; Takeru Makiyama; Mariko Omatsu-Kanbe; Hiroshi Matsuura; Minoru Horie; Seiko Ohno

  Journal of Cardiology, Apr. 2018, Peer-reviewed

  
• QT延長症候群3型の患者特異的幹細胞モデルにおいてpropranololにより遅延ナトリウム電流が減弱する(Propranolol Attenuates Late Sodium Current in Patient-specific Stem Cell Model of Long-QT Syndrome Type 3)

  Hirose Sayako; Makiyama Takeru; Melgari Dario; Wu Jie; Yokoi Fumika; Wuriyanghai Yimin; Yamamoto Yuta; Kohjitani Hirohiko; Nishiuchi Suguru; Harita Takeshi; Hayano Mamoru; Yoshimoto Jun; Ohno Seiko; Yoshida Yoshinori; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2018

  
• Lamin A/C関連心筋症の病態生理学的メカニズム分析のためのホモ接合性Lamin A/C欠損ヒト人工多能性幹細胞モデルの開発(Development of Homozygous LaminA/C Deficient Human Induced Pluripotent Stem Cell Model for Analyzing the Pathophysiological Mechanism of Lamin A/C-related Cardiomyopathy)

  Wuriyanghai Yimin; Makiyama Takeru; Nishiuchi Suguru; Yamamoto Yuta; Hirose Sayako; Hayano Mamoru; Harita Takeshi; Kohjitani Hirohiko; Yokoi Fumika; Chonabayashi Kazuhisa; Yoshida Yoshinori; Ohno Seiko; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2018

  
• hiPSC-CMの細胞特異的で精密な数学的モデリングによりIKr遮断試験における二つの正反対のAPD反応が明らかになった(Cell-Specific Precise Mathematical Modeling of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test)

  Kohjitani Hirohiko; Koda Shigeya; Himeno Yukiko; Makiyama Takeru; Yokoi Fumika; Hirose Sayako; Wuriyanghai Yimin; Yamamoto Yuta; Horie Minoru; Kimura Takeshi; Noma Akinori; Amano Akira

  日本循環器学会学術集会抄録集, Mar. 2018

  
• CALM2-D134H変異を有するQT延長症候群のヒトiPS細胞モデルではL型Ca2+チャネル不活性化がみられなかった(The Inactivation of L-type Ca2+ Cannel was Impaired in Human iPS Cell Model of Long-QT Syndrome with CALM2-D134H Mutation)

  Yamamoto Yuta; Makiyama Takeru; Harita Takeshi; Hayano Mamoru; Nishiuchi Suguru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Yokoi Fumika; Ishikawa Taisuke; Ohno Seiko; Chonabayashi Kazuhisa; Suda Kenji; Yoshida Yoshinori; Horie Minoru; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2018

  
• hiPSC-CMの細胞特異的で正確な数理モデルによって明らかにしたIKr電流遮断試験における二つのAPD反作用(Cell-specific Precise Mathematical Modeling of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test)

  Kohjitani Hirohiko; Koda Shigeya; Himeno Yukiko; Makiyama Takeru; Kimura Takeshi; Noma Akinori; Amano Akira

  The Journal of Physiological Sciences, Mar. 2018

  
• Prognostic Impact of Left Ventricular Ejection Fraction in Patients With Severe Aortic Stenosis

  Tomohiko Taniguchi; Takeshi Morimoto; Hiroki Shiomi; Kenji Ando; Norio Kanamori; Koichiro Murata; Takeshi Kitai; Kazushige Kadota; Chisato Izumi; Kenji Nakatsuma; Tomoki Sasa; Hirotoshi Watanabe; Yasuhide Kuwabara; Takeru Makiyama; Koh Ono; Satoshi Shizuta; Takao Kato; Naritatsu Saito; Kenji Minatoya; Takeshi Kimura; Takeshi Kimura; Tomohiko Taniguchi; Hiroki Shiomi; Naritatsu Saito; Masao Imai; Junichi Tazaki; Toshiaki Toyota; Hirooki Higami; Tetsuma Kawaji; Kenji Ando; Shinichi Shirai; Kengo Kourai; Takeshi Arita; Shiro Miura; Kyohei Yamaji; Takeshi Aoyama; Norio Kanamori; Tomoya Onodera; Koichiro Murata; Yutaka Furukawa; Takeshi Kitai; Kitae Kim; Kazushige Kadota; Yuichi Kawase; Keiichiro Iwasaki; Hiroshi Miyawaki; Ayumi Misao; Akimune Kuwayama; Masanobu Ohya; Takenobu Shimada; Hidewo Amano; Yoshihisa Nakagawa; Chisato Izumi; Makoto Miyake; Masashi Amano; Yusuke Takahashi; Yusuke Yoshikawa; Shunsuke Nishimura; Maiko Kuroda; Manabu Shirotani; Hirokazu Mitsuoka; Shinji Miki; Tetsu Mizoguchi; Masashi Kato; Takafumi Yokomatsu; Akihiro Kushiyama; Hidenori Yaku; Toshimitsu Watanabe; Shunichi Miyazaki; Yutaka Hirano; Mitsuo Matsuda; Shintaro Matsuda; Sachiko Sugioka; Tsukasa Inada; Kazuya Nagao; Naoki Takahashi; Kohei Fukuchi; Tomoyuki Murakami; Hiroshi Mabuchi; Teruki Takeda; Tomoko Sakaguchi; Keiko Maeda; Masayuki Yamaji; Motoyoshi Maenaka; Yutaka Tadano; Hiroki Sakamoto; Yasuyo Takeuchi; Makoto Motooka; Ryusuke Nishikawa; Hiroshi Eizawa; Keiichiro Yamane; Mitsunori Kawato; Minako Kinoshita; Kenji Aida; Takashi Tamura; Mamoru Toyofuku; Kousuke Takahashi; Euihong Ko; Masaharu Akao; Mitsuru Ishii

  JACC: Cardiovascular Interventions, 22 Jan. 2018, Peer-reviewed

  
• Clinical Manifestations and Long-Term Mortality in Lamin A/C Mutation Carriers From a Japanese Multicenter Registry.

  Nakajima K; Aiba T; Makiyama T; Nishiuchi S; Ohno S; Kato K; Yamamoto Y; Doi T; Shizuta S; Onoue K; Yagihara N; Ishikawa T; Watanabe I; Kawakami H; Oginosawa Y; Murakoshi N; Nogami A; Aonuma K; Saito Y; Kimura T; Yasuda S; Makita N; Shimizu W; Horie M; Kusano K

  Circ J., 2018, Peer-reviewed

  
• Anticoagulation therapy for venous thromboembolism in the real world: From the command vte registry

  Yugo Yamashita; Takeshi Morimoto; Hidewo Amano; Toru Takase; Seiichi Hiramori; Kitae Kim; Takashi Konishi; Masaharu Akao; Yohei Kobayashi; Takeshi Inoue; Maki Oi; Toshiaki Izumi; Kotaro Takahashi; Tomohisa Tada; Po Min Chen; Koichiro Murata; Yoshiaki Tsuyuki; Hiroshi Sakai; Syunsuke Saga; Tomoki Sasa; Jiro Sakamoto; Chinatsu Yamada; Minako Kinoshita; Kiyonori Togi; Tomoyuki Ikeda; Katsuhisa Ishii; Kazuhisa Kaneda; Hiroshi Mabuchi; Hideo Otani; Kensuke Takabayashi; Mamoru Takahashi; Hiroki Shiomi; Takeru Makiyama; Koh Ono; Takeshi Kimura

  Circulation Journal, 2018, Peer-reviewed

  
• Differential diagnosis between catecholaminergic polymorphic ventricular tachycardia and long QT syndrome type 1 ― Modified schwartz score

  Junichi Ozawa; Seiko Ohno; Yusuke Fujii; Takeru Makiyama; Hiroshi Suzuki; Akihiko Saitoh; Minoru Horie

  Circulation Journal, 2018, Peer-reviewed

  
• Clinical manifestations and long-term mortality in lamin A/C mutation carriers from a Japanese multicenter registry

  Kenzaburo Nakajima; Takeshi Aiba; Takeru Makiyama; Suguru Nishiuchi; Seiko Ohno; Koichi Kato; Yuta Yamamoto; Takahiro Doi; Satoshi Shizuta; Kenji Onoue; Nobue Yagihara; Taisuke Ishikawa; Ichiro Watanabe; Hiroshi Kawakami; Yasushi Oginosawa; Nobuyuki Murakoshi; Akihiko Nogami; Kazutaka Aonuma; Yoshihiko Saito; Takeshi Kimura; Satoshi Yasuda; Naomasa Makita; Wataru Shimizu; Minoru Horie; Kengo Kusano

  Circulation Journal, 2018, Peer-reviewed

  
• Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers

  Suguru Nishiuchi; Takeru Makiyama; Takeshi Aiba; Kenzaburo Nakajima; Sayako Hirose; Hirohiko Kohjitani; Yuta Yamamoto; Takeshi Harita; Mamoru Hayano; Yimin Wuriyanghai; Jiarong Chen; Kenichi Sasaki; Nobue Yagihara; Taisuke Ishikawa; Kenji Onoue; Nobuyuki Murakoshi; Ichiro Watanabe; Kimie Ohkubo; Hiroshi Watanabe; Seiko Ohno; Takahiro Doi; Satoshi Shizuta; Tohru Minamino; Yoshihiko Saito; Yasushi Oginosawa; Akihiko Nogami; Kazutaka Aonuma; Kengo Kusano; Naomasa Makita; Wataru Shimizu; Minoru Horie; Takeshi Kimura

  Circulation: Cardiovascular Genetics, 01 Dec. 2017, Peer-reviewed

  
• CALM2-D134H Mutation Associated With Long-QT Syndrome Delayed Inactivation of L-type Ca2+ Currents in Human iPS Cells Derived Cardiomyocytes

  Yamamoto Yuta; Makiyama Takeru; Harita Takeshi; Hayano Mamoru; Nishiuchi Suguru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Yokoi Fumika; Ishikawa Taisuke; Ohno Seiko; Chonabayashi Kazuhisa; Suda Kenji; Yoshida Yoshinori; Horie Minoru; Makita Naomasa; Kimura Takeshi

  CIRCULATION, 14 Nov. 2017, Peer-reviewed

  
• Novel Mathematical Models of All Subtypes of Induced Pluripotent Stem Cell Derived Cardiomyocytes

  Kohjitani Hirohiko; Koda Shigeya; Himeno Yukiko; Makiyama Takeru; Yokoi Fumika; Hirose Sayako; Wuriyanghai Yimin; Yamamoto Yuta; Horie Minoru; Kimura Takeshi; Noma Akinori; Amano Akira

  CIRCULATION, 14 Nov. 2017, Peer-reviewed

  
• Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers in Japan

  Nishiuchi Suguru; Aiba Takeshi; Makiyama Takeru; Nakajima Kenzaburo; Yagihara Nobue; Ishikawa Taisuke; Onoue Kenji; Murakoshi Nobuyuki; Watanabe Ichiro; Ohkubo Kimie; Watanabe Hiroshi; Ohno Seiko; Doi Takahiro; Shizuta Satoshi; Minamino Tohru; Saito Yoshihiko; Oginosawa Yasushi; Nogami Akihiko; Aonuma Kazutaka; Kusano Kengo; Makita Naomasa; Shimizu Wataru; Horie Minoru; Kimura Takeshi

  CIRCULATION, 14 Nov. 2017, Peer-reviewed

  
• Propranolol Inhibits Late Sodium Current in Long-QT Syndrome Type 3 Human Induced Pluripotent Stem Cell-drived Myocyte Model

  Hirose Sayako; Makiyama Takeru; Melgari Dario; Wu Jie; Yokoi Fumika; Wuriyanghai Yimin; Yamamoto Yuta; Kohjitani Hirohiko; Nishiuchi Suguru; Harita Takeshi; Hayano Mamoru; Yoshimoto Jun; Ohno Seiko; Yoshida Yoshinori; Horie Minoru; Kimura Takeshi

  CIRCULATION, 14 Nov. 2017, Peer-reviewed

  
• Establishment of Homozygous LMNA Knockout Human Induced Pluripotent Stem Cells for Analyzing Disease-Causing Mechanism of Laminopathies

  Wuriyanghai Yimin; Makiyama Takeru; Hayano Mamoru; Hirose Sayako; Nishiuchi Suguru; Yamamoto Yuta; Harita Takeshi; Kohjitani Hirohiko; Fumika Yokoi; Yoshida Yoshinori; Ohno Seiko; Kimura Takeshi; Horie Minoru

  CIRCULATION, 14 Nov. 2017, Peer-reviewed

  
• Human iPSC-Derived Myocyte Mmodel of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting From Enhanced Protein Degradation

  Hayano Mamoru; Makiyama Takeru; Kamakura Tsukasa; Watanabe Hiroshi; Sasaki Kenichi; Funakoshi Shunsuke; Wuriyanghai Yimin; Nishiuchi Suguru; Harita Takeshi; Yamamoto Yuta; Kohjitani Hirohiko; Hirose Sayako; Yokoi Fumika; Chen Jiarong; Baba Osamu; Horie Takahiro; Chonabayashi Kazuhisa; Ohno Seiko; Toyoda Futoshi; Yoshida Yoshinori; Ono Koh; Horie Minoru; Kimura Takeshi

  CIRCULATION, 14 Nov. 2017, Peer-reviewed

  
• Contribution of a KCNH2 variant in genotyped long QT syndrome: Romano–Ward syndrome under double mutations and acquired long QT syndrome under heterozygote

  Yusuke Fujii; Yuichi Matsumoto; Kenshi Hayashi; Wei Guang Ding; Yukinori Tomita; Daisuke Fukumoto; Yuko Wada; Mari Ichikawa; Keiko Sonoda; Junichi Ozawa; Takeru Makiyama; Seiko Ohno; Masakazu Yamagishi; Hiroshi Matsuura; Minoru Horie; Hideki Itoh

  Journal of Cardiology, Jul. 2017, Peer-reviewed

  
• Genotype-Phenotype Correlation of SCN5A Mutation for the Clinical and Electrocardiographic Characteristics of Probands with Brugada Syndrome: A Japanese Multicenter Registry

  Kenichiro Yamagata; Minoru Horie; Takeshi Aiba; Satoshi Ogawa; Yoshifusa Aizawa; Tohru Ohe; Masakazu Yamagishi; Naomasa Makita; Harumizu Sakurada; Toshihiro Tanaka; Akihiko Shimizu; Nobuhisa Hagiwara; Ryoji Kishi; Yukiko Nakano; Masahiko Takagi; Takeru Makiyama; Seiko Ohno; Keiichi Fukuda; Hiroshi Watanabe; Hiroshi Morita; Kenshi Hayashi; Kengo Kusano; Shiro Kamakura; Satoshi Yasuda; Hisao Ogawa; Yoshihiro Miyamoto; Jamie D. Kapplinger; Michael J. Ackerman; Wataru Shimizu

  Circulation, 06 Jun. 2017, Peer-reviewed

  
• Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation

  Yuta Yamamoto; Takeru Makiyama; Takeshi Harita; Kenichi Sasaki; Yimin Wuriyanghai; Mamoru Hayano; Suguru Nishiuchi; Hirohiko Kohjitani; Sayako Hirose; Jiarong Chen; Fumika Yokoi; Taisuke Ishikawa; Seiko Ohno; Kazuhisa Chonabayashi; Hideki Motomura; Yoshinori Yoshida; Minoru Horie; Naomasa Makita; Takeshi Kimura

  Human Molecular Genetics, 01 May 2017, Peer-reviewed

  
• Quantitative analysis of PKP2 and neighbouring genes in a patient with arrhythmogenic right ventricular cardiomyopathy caused by heterozygous PKP2 deletion

  Keiko Sonoda; Seiko Ohno; Sou Otuki; Koichi Kato; Nobue Yagihara; Hiroshi Watanabe; Takeru Makiyama; Tohru Minamino; Minoru Horie

  Europace, Apr. 2017, Peer-reviewed

  
• ヒトiPS由来心筋細胞の数理モデルの構築と心室筋・心房筋・洞結節様細胞の解析(Mathematical modeling and analysis of electrophysiological characteristics of the ventricular, atrial, and nodal-like hiPSC-CMs)

  Kohjitani Hirohiko; Kouda Shigeya; Himeno Yukiko; Yamamoto Natsuki; Makiyama Takeru; Harita Takeshi; Kimura Takeshi; Noma Akinori; Amano Akira

  The Journal of Physiological Sciences, Mar. 2017

  
• L型Ca2+チャネル遺伝子変異によるQT延長症候群iPS細胞モデルにおいて、l-cis-DiltiazemはCaチャネル不活性化を改善した(l-cis-diltiazem rescues impaired calcium channel inactivation in an iPSC-model of CACNA1Cassociated long-QT syndrome)

  Harita Takeshi; Makiyama Takeru; Toyoda Futoshi; Sasaki Kenichi; Nishiuchi Suguru; Hayano Mamoru; Yamamoto Yuta; Kohjitani Hirohiko; Wuriyanghai Yimin; Hirose Sayako; Chen Jiarong; Fukuyama Megumi; Chonabayashi Kazuhisa; Ohno Seiko; Yoshida Yoshinori; Ueyama Takeshi; Shimizu Akihiko; Matsuura Hiroshi; Horie Minoru; Kimura Takeshi

  The Journal of Physiological Sciences, Mar. 2017

  
• Cardiac conduction defects and Brugada syndrome: A family with overlap syndrome carrying a nonsense SCN5A mutation

  Hisaaki Aoki; Yoshihide Nakamura; Seiko Ohno; Takeru Makiyama; Minoru Horie

  Journal of Arrhythmia, 01 Feb. 2017, Peer-reviewed

  
• Development of a patient-derived induced pluripotent stem cell model for the investigation of SCN5A-D1275N-related cardiac sodium channelopathy

  Mamoru Hayano; Takeru Makiyama; Tsukasa Kamakura; Hiroshi Watanabe; Kenichi Sasaki; Shunsuke Funakoshi; Yimin Wuriyanghai; Suguru Nishiuchi; Takeshi Harita; Yuta Yamamoto; Hirohiko Kohjitani; Sayako Hirose; Fumika Yokoi; Jiarong Chen; Osamu Baba; Takahiro Horie; Kazuhisa Chonabayashi; Seiko Ohno; Futoshi Toyoda; Yoshinori Yoshida; Koh Ono; Minoru Horie; Takeshi Kimura

  Circulation Journal, 2017, Peer-reviewed

  
• Asymptomatic lower extremity deep vein thrombosis ― Clinical characteristics, management strategies, and long-term outcomes

  Yugo Yamashita; Hiroki Shiomi; Takeshi Morimoto; Tomoya Yoneda; Chinatsu Yamada; Takeru Makiyama; Takao Kato; Naritatsu Saito; Satoshi Shizuta; Koh Ono; Takeshi Kimura

  Circulation Journal, 2017, Peer-reviewed

  
• Early repolarization and risk of arrhythmia events in long QT syndrome

  Kanae Hasegawa; Hiroshi Watanabe; Takashi Hisamatsu; Seiko Ohno; Hideki Itoh; Takashi Ashihara; Hideki Hayashi; Takeru Makiyama; Tohru Minamino; Minoru Horie

  International Journal of Cardiology, 15 Nov. 2016, Peer-reviewed

  
• Basic Cardiovascular Science Best Abstract Award: Allele-specific Disruption Rescues Electrophysiological Abnormalities in Human iPS Cell Model of Long-QT Syndrome With a CALM2 Mutation

  Yuta Yamamoto; Takeru Makiyama; Takeshi Harita; Kenichi Sasaki; Mamoru Hayano; Suguru Nishiuchi; Yimin Wuriyanghai; Hirohiko Kohjitani; Sayako Hirose; Jiarong Chen; Taisuke Ishikawa; Hideki Motomura; Seiko Ohno; Kazuhisa Chonabayashi; Yoshinori Yoshida; Minoru Horie; Naomasa Makita; Takeshi Kimura

  CIRCULATION, Nov. 2016, Peer-reviewed

  
• Basic Cardiovascular Science Best Abstract Award: Allele-specific Disruption Rescues Electrophysiological Abnormalities in Human iPS Cell Model of Long-QT Syndrome With a CALM2 Mutation

  Yuta Yamamoto; Takeru Makiyama; Takeshi Harita; Kenichi Sasaki; Mamoru Hayano; Suguru Nishiuchi; Yimin Wuriyanghai; Hirohiko Kohjitani; Sayako Hirose; Jiarong Chen; Taisuke Ishikawa; Hideki Motomura; Seiko Ohno; Kazuhisa Chonabayashi; Yoshinori Yoshida; Minoru Horie; Naomasa Makita; Takeshi Kimura

  CIRCULATION, Nov. 2016, Peer-reviewed

  
• High Prevalence of Late Onset T in Patients With Long QT Syndrome Type 8

  Seiko Ohno; Junichi Ozawa; Megumi Fukuyama; Takeru Makiyama; Minoru Horie

  CIRCULATION, Nov. 2016, Peer-reviewed

  
• LMNA cardiomyopathy detected in Japanese arrhythmogenic right ventricular cardiomyopathy cohort

  Koichi Kato; Naohiko Takahashi; Yusuke Fujii; Aya Umehara; Suguru Nishiuchi; Takeru Makiyama; Seiko Ohno; Minoru Horie

  Journal of Cardiology, 01 Oct. 2016, Peer-reviewed

  
• Patient-specific human induced pluripotent stem cell model assessed with electrical pacing validates S107 as a potential therapeutic agent for catecholaminergic polymorphic ventricular tachycardia

  Kenichi Sasaki; Takeru Makiyama; Yoshinori Yoshida; Yimin Wuriyanghai; Tsukasa Kamakura; Suguru Nishiuchi; Mamoru Hayano; Takeshi Harita; Yuta Yamamoto; Hirohiko Kohjitani; Sayako Hirose; Jiarong Chen; Mihoko Kawamura; Seiko Ohno; Hideki Itoh; Ayako Takeuchi; Satoshi Matsuoka; Masaru Miura; Naokata Sumitomo; Minoru Horie; Shinya Yamanaka; Takeshi Kimura

  PLoS ONE, Oct. 2016, Peer-reviewed

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• Asymmetry of parental origin in long QT syndrome: Preferential maternal transmission of KCNQ1 variants linked to channel dysfunction

  Hideki Itoh; Myriam Berthet; Véronique Fressart; Isabelle Denjoy; Svetlana Maugenre; Didier Klug; Yuka Mizusawa; Takeru Makiyama; Nynke Hofman; Birgit Stallmeyer; Sven Zumhagen; Wataru Shimizu; Arthur A.M. Wilde; Eric Schulze-Bahr; Minoru Horie; Sophie Tezenas Du Montcel; Pascale Guicheney

  European Journal of Human Genetics, 01 Aug. 2016, Peer-reviewed

  
• A novel SCN5A mutation associated with drug induced Brugada type ECG

  Turker Isik; Makiyama Takeru; Vatta Matteo; Itoh Hideki; Ueyama Takeshi; Shimizu Akihiko; Ai Tomohiko; Horie Minoru

  PLoS ONE, Aug. 2016, Peer-reviewed

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• The genetics underlying acquired long QT syndrome: Impact for genetic screening

  Hideki Itoh; Lia Crotti; Takeshi Aiba; Carla Spazzolini; Isabelle Denjoy; Veronique Fressart; Kenshi Hayashi; Tadashi Nakajima; Seiko Ohno; Takeru Makiyama; Jie Wu; Kanae Hasegawa; Elisa Mastantuono; Federica Dagradi; Matteo Pedrazzini; Masakazu Yamagishi; Myriam Berthet; Yoshitaka Murakami; Wataru Shimizu; Pascale Guicheney; Peter J. Schwartz; Minoru Horie

  European Heart Journal, 07 May 2016, Peer-reviewed

  
• Familial lamin A/C mutation cardiomyopathy with arrhythmia substrate detected by cardiac magnetic resonance imaging and electroanatomical mapping

  Takeshi Nishi; Hiroyuki Takaoka; Nobusada Funabashi; Motoi Nishimura; Osamu Ohara; Takeru Makiyama; Marehiko Ueda; Takatsugu Kajiyama; Yoshio Kobayashi

  International Journal of Cardiology, Apr. 2016, Peer-reviewed

  
• Lamin A/C関連心筋症特異的人工多能性幹細胞由来心筋細胞における心臓イオンチャネル関連遺伝子の異常発現(Abnormal Expressions of Cardiac Ion Channels-associated Genes in Lamin A/C-related Cardiomyopathy-specific Induced Pluripotent Stem Cell-derived Cardiomyocytes)

  Nishiuchi Suguru; Makiyama Takeru; Sasaki Kenichi; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Yamamoto Yuta; Harita Takeshi; Hayano Mamoru; Ohno Seiko; Shizuta Satoshi; Yoshida Yoshinori; Horie Minoru; Kimura Takeshi

  Circulation Journal, Mar. 2016

  
• SCN5A-D1275N変異を保有する患者特異的なヒト人工多能性幹細胞由来心筋細胞の電気生理学的特徴(Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation)

  Hayano Mamoru; Makiyama Takeru; Sasaki Kenichi; Kamakura Tsukasa; Wuriyanghai Yimin; Chen Jiarong; Nishiuchi Suguru; Harita Takeshi; Yamamoto Yuta; Kohjitani Hirohiko; Hirose Sayako; Ohno Seiko; Toyoda Futoshi; Watanabe Hiroshi; Yoshida Yoshinori; Horie Minoru; Kimura Takeshi

  Circulation Journal, Mar. 2016

  
• Pediatric cohort with long QT syndrome – KCNH2 mutation carriers present late onset but severe symptoms –

  Junichi Ozawa; Seiko Ohno; Takashi Hisamatsu; Hideki Itoh; Takeru Makiyama; Hiroshi Suzuki; Akihiko Saitoh; Minoru Horie

  Circulation Journal, 25 Feb. 2016, Peer-reviewed

  
• Significance of electrocardiogram recording in high intercostal spaces in patients with early repolarization syndrome

  Tsukasa Kamakura; Mitsuru Wada; Ikutaro Nakajima; Kohei Ishibashi; Koji Miyamoto; Hideo Okamura; Takashi Noda; Takeshi Aiba; Hiroshi Takaki; Satoshi Yasuda; Hisao Ogawa; Wataru Shimizu; Takeru Makiyama; Takeshi Kimura; Shiro Kamakura; Kengo Kusano

  European Heart Journal, 14 Feb. 2016, Peer-reviewed

  
• Novel SCN10A variants associated with Brugada syndrome

  Megumi Fukuyama; Seiko Ohno; Takeru Makiyama; Minoru Horie

  Europace, 2016, Peer-reviewed

  
• Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction

  Jiarong Chen; Takeru Makiyama; Yimin Wuriyanghai; Seiko Ohno; Kenichi Sasaki; Mamoru Hayano; Takeshi Harita; Suguru Nishiuchi; Yuta Yamamoto; Takeshi Ueyama; Akihiko Shimizu; Minoru Horie; Takeshi Kimura

  Heart Rhythm, 01 Jan. 2016, Peer-reviewed

  
• Early-onset atrial fibrillation in brothers with a huge left atrial appendage

  Tetsuma Kawaji; Satoshi Shizuta; Takeru Makiyama; Takeshi Kimura

  Internal Medicine, 2016, Peer-reviewed

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• Phenotypic variability of ANK2 mutations in patients with inherited primary arrhythmia syndromes

  Mari Ichikawa; Takeshi Aiba; Seiko Ohno; Daichi Shigemizu; Junichi Ozawa; Keiko Sonoda; Megumi Fukuyama; Hideki Itoh; Yoshihiro Miyamoto; Tatsuhiko Tsunoda; Takeru Makiyama; Toshihiro Tanaka; Wataru Shimizu; Minoru Horie

  Circulation Journal, 2016, Peer-reviewed

  
• Modelling Long-QT Syndrome Associated With a Calmodulin Mutation Using Human Induced Pluripotent Stem Cells

  Yuta Yamamoto; Takeru Makiyama; Takeshi Narita; Kenichi Sasaki; Mamoru Hayano; Suguru Nishiuchi; Yimin Wuriyanghai; Hirohiko Kohjitani; Sayako Hirose; Jiarong Chen; Taisuke Ishikawa; Seiko Ohno; Yoshinori Yoshida; Minoru Hone; Naomasa Makita; Takeshi Kimura

  CIRCULATION, Nov. 2015, Peer-reviewed

  
• First clinical experience of the looped Inoue balloon technique for antegrade percutaneous balloon aortic valvuloplasty

  Mariko Yano; Naritatsu Saito; Shin Watanabe; Hirotoshi Watanabe; Ryusuke Nishikawa; Takeshi Fujino; Bingyuan Bao; Erika Yamamoto; Hiroki Watanabe; Kenji Nakatsuma; Masao Imai; Takeru Makiyama; Yoshihito Sakata; Takeshi Kimura; Kanji Inoue

  Heart and Vessels, 01 Nov. 2015, Peer-reviewed

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• Noninvasive Detection of Functional Myocardial Ischemia: Multifunction Cardiogram Evaluation in Diagnosis of Functional Coronary Ischemia Study (MED-FIT)

  Tetsuma Kawaji; Hiroki Shiomi; Takeshi Morimoto; Ryusuke Nishikawa; Mariko Yano; Hirooki Higami; Junichi Tazaki; Masao Imai; Naritatsu Saito; Takeru Makiyama; Satoshi Shizuta; Koh Ono; Takeshi Kimura

  Annals of Noninvasive Electrocardiology, 01 Sep. 2015, Peer-reviewed

  
• Evaluation of the Necessity for Cardioverter-Defibrillator Implantation in Elderly Patients with Brugada Syndrome

  Tsukasa Kamakura; Mitsuru Wada; Ikutaro Nakajima; Kohei Ishibashi; Koji Miyamoto; Hideo Okamura; Takashi Noda; Takeshi Aiba; Hiroshi Takaki; Satoshi Yasuda; Hisao Ogawa; Wataru Shimizu; Takeru Makiyama; Takeshi Kimura; Shiro Kamakura; Kengo Kusano

  Circulation: Arrhythmia and Electrophysiology, 22 Aug. 2015, Peer-reviewed

  
• Long-term clinical outcomes after sirolimus-eluting stent implantation for unprotected left main coronary artery disease

  Hirooki Higami; Hiroki Shiomi; Shunichiro Niki; Junichi Tazaki; Masao Imai; Naritatsu Saito; Takeru Makiyama; Satoshi Shizuta; Tetsuo Shioi; Koh Ono; Takeshi Kimura

  Cardiovascular Intervention and Therapeutics, 01 Jul. 2015, Peer-reviewed

  
• Mosaic KCNJ2 mutation in Andersen-Tawil syndrome: Targeted deep sequencing is useful for the detection of mosaicism

  K. Hasegawa; S. Ohno; H. Kimura; H. Itoh; T. Makiyama; Y. Yoshida; M. Horie

  Clinical Genetics, 01 Mar. 2015, Peer-reviewed

  
• Clinical impact of left ventricular outflow tract obstruction in takotsubo cardiomyopathy

  Tetsuma Kawaji; Hiroki Shiomi; Takeshi Morimoto; Junichi Tazaki; Masao Imai; Naritatsu Saito; Takeru Makiyama; Satoshi Shizuta; Koh Ono; Takeshi Kimura

  Circulation Journal, 2015, Peer-reviewed

  
• LMNA Cardiomyopathy Mimicking Arrhythmogenic Right Ventricular Cardiomyopathy

  Koichi Kato; Seiko Ohno; Takeru Makiyama; Minoru Horie

  CIRCULATION, Nov. 2014, Peer-reviewed

  
• Young Long QT Syndrome Patients With KCNH2 Mutations Have Late Onset but Severe Symptoms

  Junichi Ozawa; Seiko Ohno; Hideki Itoh; Takeru Makiyama; Minoru Hone

  CIRCULATION, Nov. 2014, Peer-reviewed

  
• The Prognosis of Andersen-Tawil Syndrome is Not So Benign as Ever Thought

  Hiromi Kimura; Hideki Itoh; Seiko Ohno; Megumi Fukuyama; Kouichi Kato; Mari Ichikawa; Yusuke Fujii; Takeru Makiyama; Minoru Hone

  CIRCULATION, Nov. 2014, Peer-reviewed

  
• Effect of preinfarction angina pectoris on long-term survival in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention

  Tomohiko Taniguchi; Hiroki Shiomi; Toshiaki Toyota; Takeshi Morimoto; Masaharu Akao; Kenji Nakatsuma; Koh Ono; Takeru Makiyama; Satoshi Shizuta; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Minoru Horie; Takeshi Kimura

  American Journal of Cardiology, 15 Oct. 2014, Peer-reviewed

  
• Long QT syndrome type 8: Novel CACNA1C mutations causing QT prolongation and variant phenotypes

  Megumi Fukuyama; Qi Wang; Koichi Kato; Seiko Ohno; Wei Guang Ding; Futoshi Toyoda; Hideki Itoh; Hiromi Kimura; Takeru Makiyama; Makoto Ito; Hiroshi Matsuura; Minoru Horie

  Europace, 08 Oct. 2014, Peer-reviewed

  
• Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction

  Seiko Ohno; Masato Omura; Mihoko Kawamura; Hiromi Kimura; Hideki Itoh; Takeru Makiyama; Hiroya Ushinohama; Naomasa Makita; Minoru Horie

  Europace, 01 Oct. 2014, Peer-reviewed

  
• Anticoagulant and antiplatelet therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention

  Koji Goto; Kentaro Nakai; Satoshi Shizuta; Takeshi Morimoto; Hiroki Shiomi; Masahiro Natsuaki; Mitsuhiko Yahata; Chihiro Ota; Koh Ono; Takeru Makiyama; Yoshihisa Nakagawa; Yutaka Furukawa; Kazushige Kadota; Yoshiki Takatsu; Takashi Tamura; Akinori Takizawa; Tsukasa Inada; Osamu Doi; Ryuji Nohara; Mitsuo Matsuda; Teruki Takeda; Masayuki Kato; Manabu Shirotani; Hiroshi Eizawa; Katsuhisa Ishii; Jong Dae Lee; Masaaki Takahashi; Minoru Horie; Mamoru Takahashi; Shinji Miki; Takeshi Aoyama; Satoru Suwa; Shuichi Hamasaki; Hisao Ogawa; Kazuaki Mitsudo; Masakiyo Nobuyoshi; Toru Kita; Takeshi Kimura

  American Journal of Cardiology, 01 Jul. 2014, Peer-reviewed

  
• Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics

  Keisuke Abe; Taku Machida; Naokata Sumitomo; Hirokazu Yamamoto; Kimie Ohkubo; Ichiro Watanabe; Takeru Makiyama; Satoki Fukae; Masaki Kohno; Daniel T. Harrell; Taisuke Ishikawa; Yukiomi Tsuji; Akihiko Nogami; Taichi Watabe; Yasushi Oginosawa; Haruhiko Abe; Koji Maemura; Hideki Motomura; Naomasa Makita

  Circulation: Arrhythmia and Electrophysiology, Jun. 2014, Peer-reviewed

  
• Brugada syndrome in spinal and bulbar muscular atrophy

  Amane Araki; Masahisa Katsuno; Keisuke Suzuki; Haruhiko Banno; Noriaki Suga; Atsushi Hashizume; Tomoo Mano; Yasuhiro Hijikata; Hideaki Nakatsuji; Hirohisa Watanabe; Masahiko Yamamoto; Takeru Makiyama; Seiko Ohno; Megumi Fukuyama; Shin Ichiro Morimoto; Minoru Horie; Gen Sobue

  Neurology, 20 May 2014, Peer-reviewed

  
• Evolution in practice patterns and long-term outcomes of coronary revascularization from bare-metal stent era to drug-eluting stent era in Japan

  Hiroki Shiomi; Takeshi Morimoto; Takeru Makiyama; Koh Ono; Yutaka Furukawa; Yoshihisa Nakagawa; Kazushige Kadota; Tomoya Onodera; Yoshiki Takatsu; Kazuaki Mitsudo; Toru Kita; Ryuzo Sakata; Hitoshi Okabayashi; Michiya Hanyu; Tatsuhiko Komiya; Fumio Yamazaki; Noboru Nishiwaki; Takeshi Kimura

  American Journal of Cardiology, 15 May 2014, Peer-reviewed

  
• Gain-of-function KCNH2 mutations in patients with Brugada syndrome

  Qi Wang; Seiko Ohno; Wei Guang Ding; Megumi Fukuyama; Akashi Miyamoto; Hideki Itoh; Takeru Makiyama; Jie Wu; Jiayu Bai; Kanae Hasegawa; Tetsuji Shinohara; Naohiko Takahashi; Akihiko Shimizu; Hiroshi Matsuura; Minoru Horie

  Journal of Cardiovascular Electrophysiology, May 2014, Peer-reviewed

  
• PROGNOSTIC IMPACT OF THE STAGED PERCUTANEOUS CORONARY INTERVENTION STRATEGY FOR NON-CULPRIT LESIONS IN ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS WITH MULTI-VESSEL DISEASE UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

  Toshiaki Toyota; Hiroki Shiomi; Tomohiko Taniguchi; Kenji Nakatsuma; Hiroki Watanabe; Koh Ono; Satoshi Shizuta; Takeru Makiyama; Yoshihisa Nakagawa; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Minoru Horie; Takeshi Kimura

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Apr. 2014, Peer-reviewed

  
• PREINFARCTION ANGINA PREDICTS BETTER 5-YEAR OUTCOMES IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION

  Tomohiko Taniguchi; Toshiaki Toyota; Hiroki Shiomi; Kenji Nakatsuma; Hiroki Watanabe; Takeru Makiyama; Satoshi Shizuta; Takeshi Morimoto; Yutaka Furukawa; Yoshihisa Nakagawa; Minoru Horie; Takeshi Kimura

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Apr. 2014, Peer-reviewed

  
• BOTH GAIN- AND LOSS-OF-FUNCTION SCN5A MUTATIONS ASSOCIATED WITH INFANTILE FATAL VENTRICULAR ARRHYTHMIAS

  Koichi Kato; Takeru Makiyama; Jie Wu; Wei-Guang Ding; Hiromi Kimura; Nobu Naiki; Seiko Ohno; Hideki Itoh; Toshio Nakanishi; Hiroshi Matsuura; Minoru Horie

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Apr. 2014, Peer-reviewed

  
• Successful EVAR for Zenith AAA Endovascular Graft Disruption

  Ryusuke Nishikawa; Hirooki Higami; Jyunichi Tazaki; Takeru Makiyama; Takeshi Kimura

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Apr. 2014, Peer-reviewed

  
• Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome

  Goro Katsuumi; Wataru Shimizu; Hiroshi Watanabe; Takashi Noda; Akihiko Nogami; Kimie Ohkubo; Takeru Makiyama; Naofumi Takehara; Yuichiro Kawamura; Yukio Hosaka; Masahito Sato; Satoki Fukae; Masaomi Chinushi; Hirotaka Oda; Masaaki Okabe; Akinori Kimura; Koji Maemura; Ichiro Watanabe; Shiro Kamakura; Minoru Horie; Yoshifusa Aizawa; Naomasa Makita; Tohru Minamino

  International Journal of Cardiology, 15 Mar. 2014, Peer-reviewed

  
• A novel HCN4 mutation, G1097 W, is associated with atrioventricular block

  Jun Zhou; Wei Guang Ding; Takeru Makiyama; Akashi Miyamoto; Yuichi Matsumoto; Hiromi Kimura; Yasuhiro Tarutani; Jin Zhao; Jie Wu; Wei Jin Zang; Hiroshi Matsuura; Minoru Horie

  Circulation Journal, 2014, Peer-reviewed

  
• Long-term efficacy and safety outcomes after unrestricted use of drug-eluting stents in patients with acute coronary syndrome: mortality and major bleeding in a single-center registry.

  Tetsuma Kawaji; Hiroki Shiomi; Takeshi Morimoto; Toshihiro Tamura; Ryusuke Nishikawa; Mariko Yano; Junichi Tazaki; Masao Imai; Naritatsu Saito; Takeru Makiyama; Satoshi Shizuta; Koh Ono; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 2014, Peer-reviewed

  
• Long-term efficacy and safety outcomes after unrestricted use of drug-eluting stents in patients with acute coronary syndrome - Mortality and major bleeding in a single-center registry

  Tetsuma Kawaji; Hiroki Shiomi; Takeshi Morimoto; Toshihiro Tamura; Ryusuke Nishikawa; Mariko Yano; Junichi Tazaki; Masao Imai; Naritatsu Saito; Takeru Makiyama; Satoshi Shizuta; Koh Ono; Takeshi Kimura

  Circulation Journal, 2014, Peer-reviewed

  
• A novel HCN4 mutation, G1097W, is associated with atrioventricular block.

  Jun Zhou; Wei-Guang Ding; Takeru Makiyama; Akashi Miyamoto; Yuichi Matsumoto; Hiromi Kimura; Yasuhiro Tarutani; Jin Zhao; Jie Wu; Wei-Jin Zang; Hiroshi Matsuura; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, 2014, Peer-reviewed

  
• Cardiac channelopathies associated with infantile fatal ventricular arrhythmias: From the cradle to the bench

  Koichi Kato; Takeru Makiyama; Jie Wu; Wei Guang Ding; Hiromi Kimura; Nobu Naiki; Seiko Ohno; Hideki Itoh; Toshio Nakanishi; Hiroshi Matsuura; Minoru Horie

  Journal of Cardiovascular Electrophysiology, 2014, Peer-reviewed

  
• A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels

  Kanae Hasegawa; Seiko Ohno; Takashi Ashihara; Hideki Itoh; Wei Guang Ding; Futoshi Toyoda; Takeru Makiyama; Hisaaki Aoki; Yoshihide Nakamura; Brian P. Delisle; Hiroshi Matsuura; Minoru Horie

  Heart Rhythm, Jan. 2014, Peer-reviewed

  
• A rare KCNE1 polymorphism, D85N, as a genetic modifier of long QT syndrome

  Kanae Hasegawa; Seiko Ohno; Hideki Itoh; Takeru Makiyama; Takeshi Aiba; Yasutaka Nakano; Wataru Shimizu; Hiroshi Matsuura; Naomasa Makita; Minoru Horie

  Journal of Arrhythmia, 2014, Peer-reviewed

  
• Efficacy of Bepridil to Prevent Ventricular Fibrillation in Early Repolarization Syndrome

  Katsuumi Goro; Shimizu Wataru; Watanabe Hiroshi; Noda Takashi; Nogami Akihiko; Ohkubo Kimie; Takehara Naofumi; Kawamura Yuichiro; Hosaka Yukio; Makiyama Takeru; Sato Masahito; Fukae Satoki; Chinushi Masaomi; Oda Hirotaka; Okabe Masaaki; Kimura Akinori; Maemura Koji; Watanabe Ichiro; Kamakura Shiro; Horie Minoru; Aizawa Yoshifusa; Makita Naomasa; Minamino Tohru

  CIRCULATION, 26 Nov. 2013, Peer-reviewed

  
• Cell Cycle Activation of Hypertrophic Cardiomyopathy: Insights From Research of Patient-Specific Induced Pluripotent Stem Cells-Derived Cardiomyocytes

  Shunsuke Funakoshi; Takeru Makiyama; Takeshi Kimura; Shinya Yamanaka; Yoshinori Yoshida

  CIRCULATION, Nov. 2013, Peer-reviewed

  
• The High Prevalence of Early Repolarization in Genotyped Long QT Syndrome

  Kanae Hasegawa; Hiroshi Waranabe; Seiko Ohno; Hideki Itoh; Takeru Makiyama; Takashi Ashihara; Hideki Hayashi; Minoru Horie

  CIRCULATION, Nov. 2013, Peer-reviewed

  
• Modeling Catecholaminergic Polymorphic Ventricular Tachycardia Using Human Induced Pluripotent Stem Cells: A Promising Tool for Drug Discovery

  Kenichi Sasaki; Takeru Makiyama; Yoshinori Yoshida; Hideki Itoh; Mihoko Kawamura; Naokata Sumitomo; Masaru Miura; Takeshi Harita; Suguru Nishiuchi; Mamoru Hayano; Yuta Yamamoto; Yimin Wurivanghai; Jiarong Chen; Tsukasa Kamakura; Tetsuhisa Hattori; Seiko Ohno; Minoru Horie; Shinya Yamanaka; Takeshi Kimura

  CIRCULATION, Nov. 2013, Peer-reviewed

  
• Genetic screening of kCNJ8 in Japanese patients with J-wave syndromes or idiopathic ventricular fibrillation

  Qi Wang; Seiko Ohno; Koichi Kato; Megumi Fukuyama; Takeru Makiyama; Hiromi Kimura; Nobu Naiki; Mihoko Kawamura; Hideki Hayashi; Minoru Horie

  Journal of Arrhythmia, Oct. 2013, Peer-reviewed

  
• Percutaneous balloon valvuloplasty for bioprosthetic mitral valve stenosis

  Yasuhiro Hamatani; Naritatsu Saito; Junichi Tazaki; Masahiro Natsuaki; Kentaro Nakai; Takeru Makiyama; Yasuhiro Sasaki; Masao Imai; Shin Watanabe; Tetsuo Shioi; Takeshi Kimura; Kanji Inoue

  Heart and Vessels, Sep. 2013, Peer-reviewed

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• Long-term follow-up of a pediatric cohort with short QT syndrome

  Juan Villafañe; Joseph Atallah; Michael H. Gollob; Philippe Maury; Christian Wolpert; Roman Gebauer; Hiroshi Watanabe; Minoru Horie; Olli Anttonen; Prince Kannankeril; Brett Faulknier; Jorge Bleiz; Takeru Makiyama; Wataru Shimizu; Robert M. Hamilton; Ming Lon Young

  Journal of the American College of Cardiology, 19 Mar. 2013, Peer-reviewed

  
• ブルガダ症候群に関連する新規SCN3B変異はNav1.5の細胞内輸送と機能に影響を与える(A Novel SCN3B Mutation Associated with Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.5)

  Ishikawa Taisuke; Takahashi Naohiko; Ohno Seiko; Sakurada Harumizu; Nakamura Kazufumi; Makiyama Takeru; Horie Minoru; Arimura Takuro; Makita Naomasa; Kimura Akinori

  Circulation Journal, Mar. 2013

  
• Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5.

  Taisuke Ishikawa; Naohiko Takahashi; Seiko Ohno; Harumizu Sakurada; Kazufumi Nakamura; Young Keun On; Jeong Euy Park; Takeru Makiyama; Minoru Horie; Takuro Arimura; Naomasa Makita; Akinori Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 2013, Peer-reviewed

  
• Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture.

  Tsukasa Kamakura; Takeru Makiyama; Kenichi Sasaki; Yoshinori Yoshida; Yimin Wuriyanghai; Jiarong Chen; Tetsuhisa Hattori; Seiko Ohno; Toru Kita; Minoru Horie; Shinya Yamanaka; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, 2013, Peer-reviewed

  
• Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia.

  Seiko Ohno; Iori Nagaoka; Megumi Fukuyama; Hiromi Kimura; Hideki Itoh; Takeru Makiyama; Akihiko Shimizu; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, 2013, Peer-reviewed

  
• L-type calcium channel mutations in Japanese patients with inherited arrhythmias.

  Megumi Fukuyama; Seiko Ohno; Qi Wang; Hiromi Kimura; Takeru Makiyama; Hideki Itoh; Makoto Ito; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, 2013, Peer-reviewed

  
• Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan.

  Mihoko Kawamura; Seiko Ohno; Nobu Naiki; Iori Nagaoka; Kenichi Dochi; Qi Wang; Kanae Hasegawa; Hiromi Kimura; Akashi Miyamoto; Yuka Mizusawa; Hideki Itoh; Takeru Makiyama; Naokata Sumitomo; Hiroya Ushinohama; Kotaro Oyama; Nobuyuki Murakoshi; Kazutaka Aonuma; Hitoshi Horigome; Takafumi Honda; Masao Yoshinaga; Makoto Ito; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, 2013, Peer-reviewed

  
• Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture

  Tsukasa Kamakura; Takeru Makiyama; Kenichi Sasaki; Yoshinori Yoshida; Yimin Wuriyanghai; Jiarong Chen; Tetsuhisa Hattori; Seiko Ohno; Toru Kita; Minoru Horie; Shinya Yamanaka; Takeshi Kimura

  Circulation Journal, 2013, Peer-reviewed

  
• A novel SCN5A mutation demonstrating a variety of clinical phenotypes in familial sick sinus syndrome

  Seiko Nakajima; Takeru Makiyama; Koji Hanazawa; Kazuaki Kaitani; Masashi Amano; Yukiko Hayama; Naoaki Onishi; Yodo Tamaki; Makoto Miyake; Toshihiro Tamura; Hirokazu Kondo; Makoto Motooka; Chisato Izumi; Yoshihisa Nakagawa; Minoru Horie

  Internal Medicine, 2013, Peer-reviewed

  
• L-Type calcium channel mutations in Japanese patients with inherited arrhythmias

  Megumi Fukuyama; Seiko Ohno; Qi Wang; Hiromi Kimura; Takeru Makiyama; Hideki Itoh; Makoto Ito; Minoru Horie

  Circulation Journal, 2013, Peer-reviewed

  
• Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan

  Mihoko Kawamura; Seiko Ohno; Nobu Naiki; Iori Nagaoka; Kenichi Dochi; Qi Wang; Kanae Hasegawa; Hiromi Kimura; Akashi Miyamoto; Yuka Mizusawa; Hideki Itoh; Takeru Makiyama; Naokata Sumitomo; Hiroya Ushinohama; Kotaro Oyama; Nobuyuki Murakoshi; Kazutaka Aonuma; Hitoshi Horigome; Takafumi Honda; Masao Yoshinaga; Makoto Ito; Minoru Horie

  Circulation Journal, 2013, Peer-reviewed

  
• Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia

  Seiko Ohno; Iori Nagaoka; Megumi Fukuyama; Hiromi Kimura; Hideki Itoh; Takeru Makiyama; Akihiko Shimizu; Minoru Horie

  Circulation Journal, 2013, Peer-reviewed

  
• Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5

  Taisuke Ishikawa; Naohiko Takahashi; Seiko Ohno; Harumizu Sakurada; Kazufumi Nakamura; Young Keun On; Jeong Euy Park; Takeru Makiyama; Minoru Horie; Takuro Arimura; Naomasa Makita; Akinori Kimura

  Circulation Journal, 2013, Peer-reviewed

  
• Novel KCNQ1 Missense Mutation Associated with Juvenile-Onset Atrial Fibrillation

  Kanae Hasegawa; Seiko Ohno; Hideki Itoh; Tetuhisa Hattori; Takeru Makiyama; Futoshi Toyoda; Wei-Guang Ding; Masaomi Chinushi; Hiroshi Matsuura; Minoru Horie

  CIRCULATION, Nov. 2012, Peer-reviewed

  
• Biophysical Properties of Na Channel the S5-S6 High Risk LQT3 Mutations of the Long QT Syndrome

  Takeshi Aiba; Futoshi Toyoda; Naomasa Makita; Hiroshi Matsuura; Hisaki Makimoto; Kenichiro Yamagata; Minoru Horie; Naoya Fukushima; Satoshi Ogawa; Yoshifusa Aizawa; Tnhru Ohe; Kengo F. Kusano; Masakazu Yamagishi; Toshihiro Tanaka; Takeru Makiyama; Masao Yoshinaga; Nobuhisa Hagiwara; Naokata Sumitomo; Shiro Kamakura; Wataru Shimizu

  CIRCULATION, Nov. 2012, Peer-reviewed

  
• Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization

  Hiroshi Watanabe; Akihiko Nogami; Kimie Ohkubo; Hiro Kawata; Yuka Hayashi; Taisuke Ishikawa; Takeru Makiyama; Satomi Nagao; Nobue Yagihara; Naofumi Takehara; Yuichiro Kawamura; Akinori Sato; Kazuki Okamura; Yukio Hosaka; Masahito Sato; Satoki Fukae; Masaomi Chinushi; Hirotaka Oda; Masaaki Okabe; Akinori Kimura; Koji Maemura; Ichiro Watanabe; Shiro Kamakura; Minoru Horie; Yoshifusa Aizawa; Wataru Shimizu; Naomasa Makita

  International Journal of Cardiology, 06 Sep. 2012, Peer-reviewed

  
• Phenotype variability in patients carrying KCNJ2 mutations

  Hiromi Kimura; Jun Zhou; Mihoko Kawamura; Hideki Itoh; Yuka Mizusawa; Wei Guang Ding; Jie Wu; Seiko Ohno; Takeru Makiyama; Akashi Miyamoto; Nobu Naiki; Qi Wang; Yu Xie; Tsugutoshi Suzuki; Shigeru Tateno; Yoshihide Nakamura; Wei Jin Zang; Makoto Ito; Hiroshi Matsuura; Minoru Horie

  Circulation: Cardiovascular Genetics, Jun. 2012, Peer-reviewed

  
• Response to letter regarding article, "electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization"

  Hiroshi Watanabe; Akihiko Nogami; Kimie Ohkubo; Hiro Kawata; Yuka Hayashi; Taisuke Ishikawa; Takeru Makiyama; Satomi Nagao; Nobue Yagihara; Naofumi Takehara; Yuichiro Kawamura; Akinori Sato; Kazuki Okamura; Yukio Hosaka; Masahito Sato; Satoki Fukae; Masaomi Chinushi; Hirotaka Oda; Masaaki Okabe; Akinori Kimura; Koji Maemura; Ichiro Watanabe; Shiro Kamakura; Minoru Horie; Yoshifusa Aizawa; Wataru Shimizu; Naomasa Makita

  Circulation: Arrhythmia and Electrophysiology, Apr. 2012

  
• A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1 currents

  Tetsuhisa Hattori; Takeru Makiyama; Masaharu Akao; Eiji Ehara; Seiko Ohno; Moritake Iguchi; Yukiko Nishio; Kenichi Sasaki; Hideki Itoh; Masayuki Yokode; Toru Kita; Minoru Horie; Takeshi Kimura

  Cardiovascular Research, 15 Mar. 2012

  
• TELETHONIN MUTATIONS ASSOCIATED WITH BRUGADA SYNDROME REDUCE CARDIAC SODIUM CURRENTS

  Isik Turker; Takeru Makiyama; Takeshi Ueyama; Wataru Shimizu; Minoru Horie; Matteo Watta; Peng-Sheng Chen; Tomohiko Ai

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Mar. 2012, Peer-reviewed

  
• A connexin40 mutation associated with a malignant variant of progressive familial heart block type I

  Naomasa Makita; Akiko Seki; Naokata Sumitomo; Halina Chkourko; Shigetomo Fukuhara; Hiroshi Watanabe; Wataru Shimizu; Connie R. Bezzina; Can Hasdemir; Hideo Mugishima; Takeru Makiyama; Alban Baruteau; Estelle Baron; Minoru Horie; Nobuhisa Hagiwara; Arthur A.M. Wilde; Vincent Probst; Hervé Le Marec; Dan M. Roden; Naoki Mochizuki; Jean Jacques Schott; Mario Delmar

  Circulation: Arrhythmia and Electrophysiology, Feb. 2012, Peer-reviewed

  
• Effects of ppis and an H2 blocker on the antiplatelet function of clopidogrel in Japanese patients under dual antiplatelet therapy

  Keiichiro Yamane; Yoshihiro Kato; Junichi Tazaki; Tomohisa Tada; Takeru Makiyama; Masao Imai; Toshikazu Jinnai; Tomoyuki Ikeda; Ryutaro Shirakawa; Takeshi Kimura; Hisanori Horiuchi

  Journal of Atherosclerosis and Thrombosis, 2012, Peer-reviewed

  
• Prediction of clopidogrel low responders by a rapid CYP2C19 activity test

  Junichi Tazaki; Toshikazu Jinnai; Tomohisa Tada; Yoshihiro Kato; Takeru Makiyama; Tomoyuki Ikeda; Keiichiro Yamane; Yumiko Naruse; Kanako Takahashi; Haruyo Watanabe; Takeshi Kimura; Hisanori Horiuchi

  Journal of Atherosclerosis and Thrombosis, 2012, Peer-reviewed

  
• Clinical and electrocardiographic characteristics of patients with short QT interval in a large hospital-based population

  Akashi Miyamoto; Hideki Hayashi; Tomohide Yoshino; Tamiro Kawaguchi; Atsushi Taniguchi; Hideki Itoh; Yoshihisa Sugimoto; Makoto Itoh; Takeru Makiyama; Joel Q. Xue; Yoshitaka Murakami; Minoru Horie

  Heart Rhythm, Jan. 2012, Peer-reviewed

  
• Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization

  Hiroshi Watanabe; Akihiko Nogami; Kimie Ohkubo; Hiro Kawata; Yuka Hayashi; Taisuke Ishikawa; Takeru Makiyama; Satomi Nagao; Nobue Yagihara; Naofumi Takehara; Yuichiro Kawamura; Akinori Sato; Kazuki Okamura; Yukio Hosaka; Masahito Sato; Satoki Fukae; Masaomi Chinushi; Hirotaka Oda; Masaaki Okabe; Akinori Kimura; Koji Maemura; Ichiro Watanabe; Shiro Kamakura; Minoru Horie; Yoshifusa Aizawa; Wataru Shimizu; Naomasa Makita

  Circulation: Arrhythmia and Electrophysiology, Dec. 2011, Peer-reviewed

  
• Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process

  Keiko Tsuji-Wakisaka; Masaharu Akao; Takahiro M. Ishii; Takashi Ashihara; Takeru Makiyama; Seiko Ohno; Futoshi Toyoda; Kenichi Dochi; Hiroshi Matsuura; Minoru Horie

  Biochimica et Biophysica Acta - Molecular Basis of Disease, Nov. 2011, Peer-reviewed

  
• Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process.

  Keiko Tsuji-Wakisaka; Masaharu Akao; Takahiro M Ishii; Takashi Ashihara; Takeru Makiyama; Seiko Ohno; Futoshi Toyoda; Kenichi Dochi; Hiroshi Matsuura; Minoru Horie

  Biochimica et biophysica acta, Nov. 2011, Peer-reviewed

  
• A novel KCNJ2 nonsense mutation, S369X, impedes trafficking and causes a limited form of andersen-tawil syndrome

  Takahiro Doi; Takeru Makiyama; Takeshi Morimoto; Yoshisumi Haruna; Keiko Tsuji; Seiko Ohno; Masaharu Akao; Yoshiaki Takahashi; Takeshi Kimura; Minoru Horie

  Circulation: Cardiovascular Genetics, Jun. 2011, Peer-reviewed

  
• KCNE5 (KCNE1L) variants are novel modulators of brugada syndrome and idiopathic ventricular fibrillation

  Seiko Ohno; Dimitar P. Zankov; Wei Guang Ding; Hideki Itoh; Takeru Makiyama; Takahiro Doi; Satoshi Shizuta; Tetsuhisa Hattori; Akashi Miyamoto; Nobu Naiki; Jules C. Hancox; Hiroshi Matsuura; Minoru Horie

  Circulation: Arrhythmia and Electrophysiology, Jun. 2011, Peer-reviewed

  
• Risk determinants in individuals with a spontaneous type 1 Brugada ECG

  Akashi Miyamoto; Hideki Hayashi; Takeru Makiyama; Tomohide Yoshino; Yuka Mizusawa; Yoshihisa Sugimoto; Makoto Ito; Joel Q. Xue; Yoshitaka Murakami; Minoru Horie

  Circulation Journal, Apr. 2011, Peer-reviewed

  
• KCNE5 Variants Are Novel Modulators of Brugada Syndrome and Idiopathic Ventricular Fibrillation

  Ohno Seiko; P. Zankov Dimitar; Ding Wei-Guang; Itoh Hideki; Makiyama Takeru; Doi Takahiro; Shizuta Satoshi; Hattori Tetsuhisa; Miyamoto Akashi; Naiki Nobu; Matsuura Hiroshi; Horie Minoru

  J Arrhythmia, 2011

  
• Risk determinants in individuals with a spontaneous type 1 Brugada ECG.

  Akashi Miyamoto; Hideki Hayashi; Takeru Makiyama; Tomohide Yoshino; Yuka Mizusawa; Yoshihisa Sugimoto; Makoto Ito; Joel Q Xue; Yoshitaka Murakami; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, 2011, Peer-reviewed

  
• A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome

  Kenichiro Yamamura; Jun Muneuchi; Kiyoshi Uike; Kazuyuki Ikeda; Hirosuke Inoue; Yasushi Takahata; Yuichi Shiokawa; Yukako Yoshikane; Takeru Makiyama; Minoru Horie; Toshiro Hara

  International Journal of Cardiology, 05 Nov. 2010, Peer-reviewed

  
• Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to congenital long QT syndrome.

  Yuko Oka; Hideki Itoh; Wei-Guang Ding; Wataru Shimizu; Takeru Makiyama; Seiko Ohno; Yukiko Nishio; Tomoko Sakaguchi; Akashi Miyamoto; Mihoko Kawamura; Hiroshi Matsuura; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, Nov. 2010, Peer-reviewed

  
• Latent Genetic Backgrounds and Molecular Pathogenesis in Acquired Long QT Syndrome with Distinct Arrhythmic Triggers

  Hideki Itoh; Yuko Oka; Wei-Guang Ding; Tomoko Sakaguchi; Hiromi Kimura; Yuka Mizusawa; Akashi Miyamoto; Jie Wu; Seiko Ohno; Takeru Makiyama; Makoto Ito; Hiroshi Matsuura; Minoru Horie

  CIRCULATION, Nov. 2010, Peer-reviewed

  
• Carvedilol, an alpha(1)- and Non-selective beta-adrenoceptor Blocker, for Prevention of Cardiac Events in Patients with Type 2 Long QT Syndrome.

  Hiromi Kimura; Hideki Itoh; Yuka Mizusawa; Akashi Miyamoto; Yuko Oka; Mihoko Kawamura; Yukiko Nishio; Tomoko Sakaguchi; Takeru Makiyama; Makoto Ito; Minoru Horie

  CIRCULATION, Nov. 2010, Peer-reviewed

  
• Clinical Features of Congenital Long QT Syndrome in Pre-elementary-age Children

  Hisaki Makimoto; Minoru Horie; Satoshi Ogawa; Yoshifusa Aizawa; Tohru Ohe; Kengo F. Kusano; Masakazu Yamagishi; Naomasa Makita; Toshihiro Tanaka; Takeru Makiyama; Masao Yoshinaga; Nobuhisa Hagiwara; Naokata Sumitomo; Yuko Yamada; Hideo Okamura; Takashi Noda; Kazuhiro Satomi; Takeshi Aiba; Naohiko Aihara; Shiro Kamakura; Yoshihiro Miyamoto; Wataru Shimizu

  CIRCULATION, Nov. 2010, Peer-reviewed

  
• Heart rate-dependent variability of cardiac events in type 2 congenital long-QT syndrome

  Iori Nagaoka; Wataru Shimizu; Yuka Mizusawa; Tomoko Sakaguchi; Hideki Itoh; Seiko Ohno; Takeru Makiyama; Ken Ichiro Yamagata; Hisaki Makimoto; Yoshihiro Miyamoto; Shiro Kamakura; Minoru Horie

  Europace, Nov. 2010, Peer-reviewed

  
• Long QT syndrome with compound mutations is associated with a more severe phenotype: A Japanese multicenter study

  Hideki Itoh; Wataru Shimizu; Kenshi Hayashi; Kenichiro Yamagata; Tomoko Sakaguchi; Seiko Ohno; Takeru Makiyama; Masaharu Akao; Tomohiko Ai; Takashi Noda; Aya Miyazaki; Yoshihiro Miyamoto; Masakazu Yamagishi; Shiro Kamakura; Minoru Horie

  Heart Rhythm, Oct. 2010, Peer-reviewed

  
• High prevalence of early repolarization in short QT syndrome

  Hiroshi Watanabe; Takeru Makiyama; Taku Koyama; Prince J. Kannankeril; Shinji Seto; Kazuki Okamura; Hirotaka Oda; Hideki Itoh; Masahiko Okada; Naohito Tanabe; Nobue Yagihara; Shiro Kamakura; Minoru Horie; Yoshifusa Aizawa; Wataru Shimizu

  Heart Rhythm, May 2010, Peer-reviewed

  
• Atrioventricular block-induced torsades de pointes with clinical and molecular backgrounds similar to congenital long QT syndrome

  Yuko Oka; Hideki Itoh; Wei Guang Ding; Wataru Shimizu; Takeru Makiyama; Seiko Ohno; Yukiko Nishio; Tomoko Sakaguchi; Akashi Miyamoto; Mihoko Kawamura; Hiroshi Matsuura; Minoru Horie

  Circulation Journal, 2010, Peer-reviewed

  
• A Novel Gain-of-function KCNJ2 Mutation Associated With Short QT Syndrome Impairs Inward Rectification of Kir 2.1 Currents

  Tetsuhisa Hattori; Takeru Makiyama; Masaharu Akao; Eiji Ehara; Seiko Ohno; Yukiko Nishio; Hideki Itoh; Masayuki Yokode; Takeshi Kimura; Minoru Horie

  CIRCULATION, Nov. 2009, Peer-reviewed

  
• Association of Early Repolarization With Arrhythmic Events in Short QT Syndrome

  Hiroshi Watanabe; Takeru Makiyama; Prince J. Kannankeril; Shinji Seto; Kazuki Okamura; Hirotaka Oda; Hideki Ito; Minoru Horie; Yoshifusa Aizawa; Wataru Shimizu

  CIRCULATION, Nov. 2009, Peer-reviewed

  
• Novel KCNE5 Mutations Are Associated With Brugada Syndrome and Idiopathic Ventricular Fibrillation

  Seiko Ohno; Dimitar P. Zankov; Ding Wei-Guang; Takeru Makiyama; Tetsuhisa Hattori; Takahiro Doi; Satoshi Shizuta; Takeshi Kimura; Hiroshi Matsuura; Minoru Horie

  CIRCULATION, Nov. 2009, Peer-reviewed

  
• Clinical Phenotype and Prognosis of Probands With Brugada Syndrome in Relation to SCN5A Mutation. - Japanese Brugada Syndrome Multicenter Registry

  Kenichiro Yamagata; Minoru Horie; Satoshi Ogawa; Yoshifusa Aizawa; Kengo F. Kusano; Tohru Ohe; Masakazu Yamagishi; Naomasa Makita; Toshihro Tanaka; Takeru Makiyama; Masahanu Akao; Nobuhisa Hagiwara; Ryoji Kishi; Yuko Yamada; Hideo Okamura; Takashi Noda; Kazuhiro Satomi; Kazuhiro Suyama; Naohiko Ahara; Yoshihisa Miyamoto; Shiro Kamakura; Wataru Shimizu

  CIRCULATION, Nov. 2009, Peer-reviewed

  
• Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome

  Minoru Horie; Hideki Itoh; Tomoko Sakaguchi; Wei Guang Ding; Eiichi Watanabe; Ichiro Watanabe; Yukiko Nishio; Takeru Makiyama; Seiko Ohno; Masaharu Akao; Yukei Higashi; Naoko Zenda; Tomoki Kubota; Chikara Mori; Katsunori Okajima; Tetsuya Haruna; Akashi Miyamoto; Mihoko Kawamura; Katsuya Ishida; Iori Nagaoka; Yuko Oka; Yuko Nakazawa; Takenori Yao; Hikari Jo; Yoshihisa Sugimoto; Takashi Ashihara; Hideki Hayashi; Makoto Ito; Keiji Imoto; Hiroshi Matsuura

  Circulation: Arrhythmia and Electrophysiology, Oct. 2009, Peer-reviewed

  
• D85N, a KCNE1 Polymorphism, Is a Disease-Causing Gene Variant in Long QT Syndrome

  Yukiko Nishio; Takeru Makiyama; Hideki Itoh; Tomoko Sakaguchi; Seiko Ohno; Yin Zhi Gong; Satoshi Yamamoto; Tomoya Ozawa; Wei Guang Ding; Futoshi Toyoda; Mihoko Kawamura; Masaharu Akao; Hiroshi Matsuura; Takeshi Kimura; Toru Kita; Minoru Horie

  Journal of the American College of Cardiology, 25 Aug. 2009, Peer-reviewed

  
• Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan.

  Toshikazu Jinnai; Hisanori Horiuchi; Takeru Makiyama; Junichi Tazaki; Tomohisa Tada; Masaharu Akao; Koh Ono; Kozo Hoshino; Yumiko Naruse; Kanako Takahashi; Haruyo Watanabe; Toru Kita; Takeshi Kimura

  Circulation journal : official journal of the Japanese Circulation Society, Aug. 2009, Peer-reviewed

  
• Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan

  Toshikazu Jinnai; Hisanori Horiuchi; Takeru Makiyama; Junichi Tazaki; Tomohisa Tada; Masaharu Akao; Koh Ono; Kozo Hoshino; Yumiko Naruse; Kanako Takahashi; Haruyo Watanabe; Toru Kita; Takeshi Kimura

  Circulation Journal, Aug. 2009, Peer-reviewed

  
• The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: Evidence from two-photon imaging

  Masashi Kato; Masaharu Akao; Madoka Matsumoto-Ida; Takeru Makiyama; Moritake Iguchi; Toshihiro Takeda; Shigeomi Shimizu; Toru Kita

  Cardiovascular Research, Jul. 2009, Peer-reviewed

  
• Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome

  Seiko Ohno; Futoshi Toyoda; Dimitar P. Zankov; Hidetada Yoshida; Takeru Makiyama; Keiko Tsuji; Toshihiro Honda; Kazuhiko Obayashi; Hisao Ueyama; Wataru Shimizu; Yoshihiro Miyamoto; Shiro Kamakura; Hiroshi Matsuura; Toru Kita; Minoru Horie

  Human Mutation, Apr. 2009, Peer-reviewed

  
• Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long-term follow-up.

  Mihoko Kawamura; Tomoya Ozawa; Takenori Yao; Takashi Ashihara; Yoshihisa Sugimoto; Takafumi Yagi; Hideki Itoh; Makoto Ito; Takeru Makiyama; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, Mar. 2009, Peer-reviewed

  
• Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in Brugada syndrome with a novel nonsense mutation in the SCN5A gene during long-term follow-up

  Mihoko Kawamura; Tomoya Ozawa; Takenori Yao; Takashi Ashihara; Yoshihisa Sugimoto; Takafumi Yagi; Hideki Itoh; Makoto Ito; Takeru Makiyama; Minoru Horie

  Circulation Journal, Mar. 2009, Peer-reviewed

  
• Drug-induced Brugada ECG Changes Associated With A Novel SCN5A Mutation In A Patient With Atrial Arrhythmias

  Samani Kaveh; Ai Tomohiko; Ueyama Takeshi; Makiyama Takeru; Vatta Matteo; Sohma Yoshiro; Xi Yutao; Itoh Hideki; Horie Minoru; Shimizu Akihiko; Cheng Jie

  BIOPHYSICAL JOURNAL, Feb. 2009, Peer-reviewed

  
• A Novel SCN5A Gain-of-Function Mutation M1875T Associated With Familial Atrial Fibrillation

  Takeru Makiyama; Masaharu Akao; Satoshi Shizuta; Takahiro Doi; Kei Nishiyama; Yuko Oka; Seiko Ohno; Yukiko Nishio; Keiko Tsuji; Hideki Itoh; Takeshi Kimura; Toru Kita; Minoru Horie

  Journal of the American College of Cardiology, 14 Oct. 2008, Peer-reviewed

  
• Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome.

  Takeru Makiyama; Masaharu Akao; Yoshisumi Haruna; Keiko Tsuji; Takahiro Doi; Seiko Ohno; Yukiko Nishio; Toru Kita; Minoru Horie

  Circulation journal : official journal of the Japanese Circulation Society, Oct. 2008, Peer-reviewed

  
• A Novel SCN5A Gain-of-Function Mutation M1875T Associated with Familial Atrial Fibrillation

  Takeru Makiyama; Masaharu Akao; Satoshi Shizuta; Takahiro Doi; Kel Nishiyama; Oka Yuko; Yukiko Nishio; Keiko Tsuji; Hideki Itoh; Takeshi Kimura; Toru Kita; Minoru Horie

  CIRCULATION, Oct. 2008, Peer-reviewed

  
• Identification and Functional Characterization of a Novel Intronic Splicing Mutation in KCNQ1 Associated with Long QT Syndrome

  Keiko Tsuji; Masaharu Akao; Takahiro Ishii; Takashi Ashihara; Takeru Makiyama; Seiko Ohno; Futoshi Toyoda; Yukiko Nishio; Tomoko Sakaguchi; Hiroshi Matsuura; Minoru Horie

  CIRCULATION, Oct. 2008, Peer-reviewed

  
• Age- and genotype-specific triggers for life-threatening arrhythmia in the genotyped long QT syndrome

  Tomoko Sakaguchi; Wataru Shimizu; Hideki Itoh; Takashi Noda; Yoshihiro Miyamoto; Iori Nagaoka; Yuko Oka; Takashi Ashihara; Makoto Ito; Keiko Tsuji; Seiko Ohno; Takeru Makiyama; Shiro Kamakura; Minoru Horie

  Journal of Cardiovascular Electrophysiology, Aug. 2008, Peer-reviewed

  
• The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome

  Naomasa Makita; Elijah Behr; Wataru Shimizu; Minoru Horie; Akihiko Sunami; Lia Crotti; Eric Schulze-Bahr; Shigetomo Fukuhara; Naoki Mochizuki; Takeru Makiyama; Hideki Itoh; Michael Christiansen; Pascal McKeown; Koji Miyamoto; Shiro Kamakura; Hiroyuki Tsutsui; Peter J. Schwartz; Alfred L. George; Dan M. Roden

  Journal of Clinical Investigation, 02 Jun. 2008, Peer-reviewed

  
• The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome

  Naomasa Makita; Elijah Behr; Wataru Shimizu; Minoru Horie; Akihiko Sunami; Lia Crotti; Eric Schulze-Bahr; Shigetomo Fukuhara; Naoki Mochizuki; Takeru Makiyama; Hideki Itoh; Michael Christiansen; Pascal McKeown; Koji Miyamoto; Shiro Kamakura; Hiroyuki Tsutsui; Peter J. Schwartz; Alfred L. George; Dan M. Roden

  JOURNAL OF CLINICAL INVESTIGATION, Jun. 2008, Peer-reviewed

  
• Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome

  Takeru Makiyama; Masaharu Akao; Yoshisumi Haruna; Keiko Tsuji; Takahiro Doi; Seiko Ohno; Yukiko Nishio; Toru Kita; Minoru Horie

  Circulation Journal, 2008, Peer-reviewed

  
• A novel mutation associated with Jervell and Lange-Nielsen syndrome in a Japanese family

  Seiko Ohno; Tomoyuki Kubota; Hidetada Yoshida; Keiko Tsuji; Takeru Makiyama; Satsuki Yamada; Keisuke Kuga; Iwao Yamaguchi; Tom Kita; Minoru Horie

  Circulation Journal, 2008, Peer-reviewed

  
• Mutation site dependent variability of cardiac events in Japanese LQT2 form of congenital long-QT syndrome

  Iori Nagaoka; Wataru Shimizu; Hideki Itoh; Satoshi Yamamoto; Tomoko Sakaguchi; Yuko Oka; Keiko Tsuji; Takashi Ashihara; Makoto Ito; Hidetada Yoshida; Seiko Ohno; Takeru Makiyama; Yoshihiro Miyamoto; Takashi Noda; Shiro Kamakura; Masaharu Akao; Minoru Horie

  Circulation Journal, 2008, Peer-reviewed

  
• [Severe arrythmic events triggered by fever in a case of Brugada syndrome].

  Koji Hanazawa; Toshihiro Tamura; Takahiro Doi; Satoshi Shizuta; Takeru Makiyama; Yutaka Furukawa; Yoshihisa Nakagawa; Toru Kita; Masaharu Akao; Takeshi Kimura

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 10 Nov. 2007, Peer-reviewed

  
• Familial dilated cardiomyopathy with conduction disease caused by a lamin A/C mutation: Efficacy of the cardiac resynchronization therapy with a defibrillator

  Takeru Makiyama; Masaharu Akao; Satoshi Shizuta; Takahirci Doi; Seiko Ohno; Yukiko Nishio; Takeshi Kimura; Minoru Horie; Toru Kita

  CIRCULATION, Oct. 2007, Peer-reviewed

  
• Age-related triggers for life-threatning arrhythmia in the genotyped long QT syndrome

  Tomoko Sakaguchi; Wataru Shimizu; Hideki Ito; Takashi Noda; Yoshihiro Miyamoto; Iori Nagaoka; Takashi Ashihara; Makoto Ito; Keiko Tsuji; Seiko Ohno; Takeru Makiyama; Shiro Kamakura; Minoru Horie

  CIRCULATION, Oct. 2007, Peer-reviewed

  
• Variable genetic backgrounds between congenital and acquired long QT syndromes

  Hideki Itoh; Takeru Makiyama; Seiko Ohno; Yuko Oka; Tomoko Sakaguchi; Iori Nagaoka; Takashi Ashihara; Makoto Ito; Masaharu Akao; Minoru Horie

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Mar. 2007, Peer-reviewed

  
• Mechanistic basis for the pathogenesis of long QT syndrome associated with a common splicing mutation in KCNQ1 gene

  Keiko Tsuji; Masaharu Akao; Takahiro M. Ishii; Seiko Ohno; Takeru Makiyama; Kotoe Takenaka; Takahiro Doi; Yoshisumi Haruna; Hidetada Yoshida; Toshihiro Nakashima; Toru Kita; Minoru Horie

  Journal of Molecular and Cellular Cardiology, Mar. 2007, Peer-reviewed

  
• N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome

  Seiko Ohno; Dimitar P. Zankov; Hidetada Yoshida; Keiko Tsuji; Takeru Makiyama; Hideki Itoh; Masaharu Akao; Jules C. Hancox; Toru Kita; Minoru Horie

  Heart Rhythm, Mar. 2007, Peer-reviewed

  
• Genotype-phenotype correlations of KCNJ2 mutations in Japanese patients with Andersen-Tawil syndrome.

  Yoshisumi Haruna; Atsushi Kobori; Takeru Makiyama; Hidetada Yoshida; Masaharu Akao; Takahiro Doi; Keiko Tsuji; Seiko Ono; Yukiko Nishio; Wataru Shimizu; Takehiko Inoue; Tomoaki Murakami; Naoya Tsuboi; Hideo Yamanouchi; Hiroya Ushinohama; Yoshihide Nakamura; Masao Yoshinaga; Hitoshi Horigome; Yoshifusa Aizawa; Toru Kita; Minoru Horie

  Human mutation, Feb. 2007, Peer-reviewed

  
• Mechanistic basis for the pathogenesis of long QT syndrome caused by a splicing mutation in KCNQ1 gene

  Keiko Tsuji; Masaharu Akao; Takahiro Ishii; Seiko Ohno; Takeru Makiyama; Takahiro Doi; Yoshisumi Haruna; Hidetada Yoshida; Toshihiro Nakashima; Toro Kita; Minoru Horie

  CIRCULATION, Oct. 2006, Peer-reviewed

  
• WTC deafness Kyoto (dfk): A rat model for extensive investigations of Kcnq1 functions

  Hiroshi Gohma; Takashi Kuramoto; Mitsuru Kuwamura; Ryoko Okajima; Noriaki Tanimoto; Ken Ichi Yamasaki; Satoshi Nakanishi; Kazuhiro Kitada; Takeru Makiyama; Masaharu Akao; Toru Kita; Masashi Sasa; Tadao Serikawa

  Physiological Genomics, 23 Feb. 2006, Peer-reviewed

  
• Blockade of angiotensin II type 1 receptor improves the arrhythmia morbidity in mice with left ventricular hypertrophy

  Cuntai Zhang; Shinji Yasuno; Koichiro Kuwahara; Dimitar P. Zankov; Atsushi Kobori; Takeru Makiyama; Minoru Horie

  Circulation Journal, 2006, Peer-reviewed

  
• High risk for bradyarrhythmic complications in patients with Brugada syndrome caused by SCN5A gene mutations

  Takeru Makiyama; Masaharu Akao; Keiko Tsuji; Takahiro Doi; Seiko Ohno; Kotoe Takenaka; Atsushi Kobori; Tomonori Ninomiya; Hidetada Yoshida; Makoto Takano; Naomasa Makita; Fumiko Yanagisawa; Yukei Higashi; Youichi Takeyama; Toru Kita; Minoru Horie

  Journal of the American College of Cardiology, 06 Dec. 2005, Peer-reviewed

  
• Double SCN5A mutation underlying asymptomatic Brugada syndrome

  Hisataka Yokoi; Naomasa Makita; Koji Sasaki; Yasuhiro Takagi; Yasuo Okumura; Tetsuo Nishino; Takeru Makiyama; Akira Kitabatake; Minoru Horie; Ichiro Watanabe; Hiroyuki Tsutsui

  Heart Rhythm, Mar. 2005, Peer-reviewed

  
• Additional Gene Variants Reduce Effectiveness of Beta-Blockers in the LQT1 Form of Long QT Syndrome

  Atsushi Kobori; Nobuaki Sarai; Wataru Shimizu; Yoshihide Nakamura; Yosuke Murakami; Takeru Makiyama; Seiko Ohno; Kotoe Takenaka; Tomonori Ninomiya; Yuichiro Fujiwara; Satoshi Matsuoka; Makoto Takano; Akinori Noma; Toru Kita; Minoru Horie

  Journal of Cardiovascular Electrophysiology, Feb. 2004, Peer-reviewed

  
• A Long Dialysis Period has a Strong Impact on Restenosis after Percutaneous Coronary Intervention (PCI) in Chronic Hemodialysis Patients

  Yasuhiro Nakashima; Kazuaki Kataoka; Ryoji Taniguchi; Tadashi Miyamoto; Kozo Hoshino-Nagai; Takeru Makiyama; Takao Kato; Takahiro Horie; Kazuya Nagao; Yoshiki Takatsu

  Japanese Journal of Interventional Cardiology, 2004, Peer-reviewed

  
• Vessel Size, Not Stent Length, Is the Most Important Predictor of Restenosis after NIR Stent Implantation

  Tadashi Miyamoto; Kozo Nagai; Yukihito Sato; Takeru Makiyama; Kazuya Nagao; Yashiro Nakashima; Takao Kato; Takahiro Horie; Ryoji Taniguchi; Tasuku Yamada; Kazuaki Kataoka; Yoshiki Takatsu

  Japanese Journal of Interventional Cardiology, 2004, Peer-reviewed

  
• Measurements of cardiac troponin T in patients with hypertrophic cardiomyopathy

  Yukihito Sato; R. Taniguchi; K. Nagai; T. Makiyama; H. Okada; T. Yamada; A. Matsumori; Y. Takatsu

  Heart, 01 Jun. 2003, Peer-reviewed

  
• Serum cardiac troponin T and plasma brain natriuretic peptide in patients with cardiac decompensation

  Yukihito Sato; R. Taniguchi; T. Makiyama; K. Nagai; H. Okada; T. Yamada; A. Matsumori; Y. Takatsu

  Heart, Dec. 2002, Peer-reviewed

  
• Percutaneous pericardial biopsy for the diagnosis of pericardial effusion : Case reports

  Takeru Makiyama; Yukihito Sato; Ryoji Taniguchi; Kozo Nagai; Hideshi Okada; Yasuhiro Nakashima; Shigetake Sasayama; Akira Matumori; Yoshiki Takatsu

  Respiration and Circulation, Mar. 2001, Peer-reviewed

  
• Persistently increased serum concentrations of cardiac troponin T in patients with idiopathic dilated cardiomyopathy are predictive of adverse outcomes

  Yukihito Sato; Tasuku Yamada; Ryoji Taniguchi; Kozo Nagai; Takeru Makiyama; Hideshi Okada; Kazuaki Kataoka; Haruyasu Ito; Akira Matsumori; Shigetake Sasayama; Yoshiki Takatsu

  Circulation, 23 Jan. 2001, Peer-reviewed

  
• Early and late clinical outcomes of multiLink stent implantation

  Y. Sato; T. Yamada; R. Taniguchi; K. Nagai; T. Makiyama; H. Okada; Y. Takatsu

  Japanese Journal of Interventional Cardiology, 2001, Peer-reviewed

  

Misc.

• M16メタロエンドペプチダーゼによる心拍数制御機構

  大野美紀子; 松浦博; 西清人; 糀谷泰彦; 牧山武; 池田真也; 西英一郎

  日本循環薬理学会口演要旨集, 2024

  
• Development of Deep-Generative Models with Fine-tuning Techniques for Genetic Risk Prediction and Prognosis Stratification of Hereditary Arrhythmic Disease

  三谷孟司; 三谷孟司; 糀谷泰彦; 糀谷泰彦; 岡本有司; 相澤卓範; 牧山武; 牧山武; 大野聖子; 堀江稔; 奥野恭史

  日本循環器学会学術集会(Web), 2024

  
• 持続性心房細動に対するアブレーション中に大量の右左シャントによる低酸素血症で救命困難となった不整脈原性右室心筋症の1例

  井上智之; 喜多村恭平; 羽賀博典; 森永晃史; 米田史哉; 西脇修司; 田中宗和; 糀谷泰彦; 牧山武; 尾野亘; 静田聡

  日本心臓病学会学術集会(Web), 2023

  
• Development of Precise Genetic Prognostic Model for Hereditary Arrhythmia Disease Using Machine Learning

  KOHJITANI Hirohiko; KOHJITANI Hirohiko; MITANI Takeshi; OKAMOTO Yuji; AIZAWA Takanori; MAKIYAMA Takeru; MAKIYAMA Takeru; KASHIWA Asami; IMAMURA Tomohiko; OHNO Seiko; HORIE Minoru; SHIZUTA Satoshi; SHIZUTA Satoshi; KIMURA Takeshi; KIMURA Takeshi; OKUNO Yasushi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2022

  
• Arrhythmic Risk is NOT Homogeneous in C-Terminal KCNQ1 Variants of Long QT Syndrome

  KASHIWA Asami; MAKIYAMA Takeru; WADA Yuko; OZAWA Junichi; AIZAWA Takanori; IMAMURA Tomohiko; HUANG Hai; GAO Jingshan; KOHJITANI Hirohiko; OHNO Seiko; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2022

  
• Novel CPVT-Associated Calmodulin Mutation Activating RyR2 Channels Causes Robust Arrhythmogenicity in iPS Cell Model

  GAO Jingshan; MAKIYAMA Takeru; YAMAMOTO Yuta; KOBAYASHI Takuya; AOKI Hisaaki; MAURISSEN L Thomas; KASHIWA Asami; IMAMURA Tomohiko; AIZAWA Takanori; HUANG Hai; KOHJITANI Hirohiko; KATO Koichi; YOSHIDA Yoshinori; MAKITA Naomasa; WOLTJEN Knut; OHNO Seiko; KUREBAYASHI Nagomi; MURAYAMA Takashi; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2022

  
• Clinical Characteristics and Risk Stratification in Pediatric Brugada Syndrome

  IMAMURA Tomohiko; MAKIYAMA Takeru; OZAWA Junichi; HUANG Hai; AIZAWA Takanori; GAO Jingshan; KASHIWA Asami; KOHJITANI Hirohiko; KATO Koichi; AOKI Hisaaki; SUZUKI Hiroshi; SONODA Keiko; OHNO Seiko; SUMITOMO Naokata; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2022

  
• Late Sodium Current Inhibitor Shortens Prolonged Action Potential Durations in iPS Cell-derived Cardiomyocytes of long QT syndrome associated with Cav 1.2 Ion Selectivity Disruption

  KASHIWA Asami; MAKIYAMA Takeru; KOUJITANI Hirohiko; YAMAMOTO Yuta; YAMAMOTO Yuta; GAO Jingshan; HUANG Hai; IMAMURA Tomohiko; AIZAWA Takanori; ISHIKAWA Taisuke; ONO Seiko; TOYODA Futoshi; SATO Seiichi; TAKAHASHI Kazuhiro; HORIE Minoru; KIMURA Takeshi

  Journal of Physiological Sciences (Web), 2021

  
• Usefulness of Collaboration Between Mathematical Models and Cell Engineering for Elucidating Complex Disease Mechanisms and Discover Effective Drugs

  KOHJITANI Hirohiko; KASHIWA Asami; MAKIYAMA Takeru; ISHIKAWA Taisuke; TOYODA Futoshi; OHNO Seiko; HUANG Hai; GAO Jingshan; IMAMURA Tomohiko; AIZAWA Takanori; SHIZUTA Satoshi; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2021

  
• Inhibition of Late Sodium Current Shortens Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 Ion Selectivity

  KASHIWA Asami; MAKIYAMA Takeru; KOHJITANI Hirohiko; MAURISSEN Thomas; WURIYANGHAI Yimin; YAMAMOTO Yuta; GAO Jingshan; HUANG Hai; IMAMURA Tomohiko; AIZAWA Takanori; ISHIKAWA Taisuke; OHNO Seiko; TOYODA Futoshi; SATO Seiich; TAKAHASHI Kazuhiro; WOLTJEN Knut; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2021

  
• Antisense-Mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy

  YAMAMOTO Yuta; MAKIYAMA Takeru; KONDO Yoshiki; IRIYAMA Yusuke; WURIYANGHAI Yimin; KOHJITANI Hirohiko; GAO Jingshan; KASHIWA Asami; HUANG Hai; AIZAWA Takanori; IMAMURA Tomohiko; ISHIKAWA Taisuke; YOSHIDA Yoshinori; OHNO Seiko; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2021

  
• Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction Using iPS Cells

  MAKIYAMA Takeru; GAO Jingshan; YAMAMOTO Yuta; KASHIWA Asami; AIZAWA Takanori; IMAMURA Tomohiko; HUANG Hai; KOHJITANI Hirohiko; KATO Kouichi; ISHIKAWA Taisuke; AOKI Hisaaki; TOYODA Futoshi; WOLTEN Knut; YOSHIDA Yoshinori; OHNO Seiko; MAKITA Naomasa; KIMURA Takeshi

  日本循環器学会学術集会(Web), 2021

  
• A High-Throughput Phenotype-Based Subtype Classification of Long-QT Syndrome Using Induced Pluripotent Stem Cell Model

  Daisuke Yoshinaga; Shiro Baba; Takeru Makiyama; Hirofumi Shibata; Takuya Hirata; Hirohiko Kohjitani; Yimin Wuriyanghai; Yuta Yamamoto; Bruce Conklin; Minoru Horie; Junko Takita; Toshio Heike

  CIRCULATION, Nov. 2019

  
• Single Cell Electrophysiological Analysis of iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System

  YAMAMOTO Yuta; MAKIYAMA Takeru; WURIYANGHAI Yimin; KOHJITANI Hirohiko; HIROSE Sayako; GAO Jingshan; KASHIWA Asami; HUANG Hai; ISHIKAWA Taisuke; OHNO Seiko; CHONABAYASHI Kazuhisa; SUDA Kenji; YOSHIDA Yoshinori; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2019

  
• Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing

  KOHJITANI Hirohiko; KOUDA Shigeya; HIMENO Yukiko; MAKIYAMA Takeru; HUANG Hai; GAO Jingshan; KASHIWA Asami; WURIYANGHAI Yimin; YOSHINAGA Daisuke; KIMURA Takeshi; AMANO Akira

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2019

  
• Impaired response of KCNQ1 channel to beta-adrenergic stimulation in human iPSC-derived cardiomyocytes carrying a CALM2-N98S mutation associated with long QT syndrome

  YAMAMOTO Yuta; MAKIYAMA Takeru; WURIYANGHAI Yimin; KOHJITANI Hirohiko; HIROSE Sayako; GAO Jingshan; KASHIWA Asami; HAI Huang; AIZAWA Takanori; IMAMURA Tomohiko; ISHIKAWA Taisuke; MOTOMURA Hideki; YOSHIDA Yoshinori; OHNO Seiko; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  Journal of Arrhythmia (Web), 2019

  
• Patients characteristics of idiopathic ventricular fibrillation carrying SCN5A mutations without Brugada or long QT syndrome

  AIZAWA Takanori; MAKIYAMA Takeru; HUANG Hai; IMAMURA Tomohiko; GAO JingShan; KASHIWA Asami; YIMIN Wuriyanghai; KOHJITANI Hirohiko; YAMAMOTO Yuta; OHNO Seiko; HORIE Minoru

  Journal of Arrhythmia (Web), 2019

  
• Algorithmic auto-recreation system of hiPSC-CMs simulation and prediction of drug testing

  KOHJITANI Hirohiko; KOUDA Shigeya; MAKIYAMA Takeru; IMAMURA Tomohiko; AIZAWA Takanori; KASHIWA Asami; GAO JingShan; HUANG Hai; WURIYANGHAI Yimin; YAMAMOTO Yuta; SIZUTA Satoshi; KIMURA Takeshi; NOMA Akinori

  Journal of Arrhythmia (Web), 2019

  
• Clinical Aspects of Brugada Syndrome in Children: The Impact of Gender and Age on the Prognosis

  今村知彦; 牧山武; 小澤淳一; 相澤卓範; 柏麻美; 糀谷泰彦; 加藤浩一; 青木寿明; 鈴木博; 園田桂子; 大野聖子; 住友直方; 堀江稔; 木村剛

  日本循環器学会学術集会(Web), 2022

  
• Modeling inherited arrhythmias using human induced pluripotent stem cell-derived cardiomyocytes: Diagnostic tools, investigation of pathogenic mechanisms, development of new therapeutic approaches.

  牧山武; 牧山武; 山本雄大; 山本雄大; 吉永大介; 吉永大介; 廣瀬紗也子; 相澤卓範; 柏麻美; GAO Gingshan; 今村知彦; HUANG Hai; 糀谷泰彦; 糀谷泰彦; 大野聖子; 蒔田直昌; 堀江稔; 木村剛

  循環器内科, 2021

  
• Clinical Characteristics of Pediatric Brugada Syndrome in Japanese Registry

  今村知彦; 牧山武; 小澤淳一; 相澤卓範; 柏麻美; 山本雄大; 糀谷泰彦; 加藤浩一; 青木寿明; 大野聖子; 鈴木博; 住友直方; 吉永正夫; 堀江稔; 木村剛

  日本循環器学会学術集会(Web), 2021

  
• 3 Mutant KCNE3 Reduces Repolarizing Potassium Current And Causes Long QT Syndrome(Plenary Session 4 (PL-4) (A) New Scientific Approaches to QT Prolongation,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Ohno Seiko; Toyoda Futoshi; Zankov Dimitar; Yoshida Hidetada; Makiyama Takeru; Tsuji Keiko; Honda Toshihiro; Oobayashi Kazuhiko; Ueyama Hisao; Shimizu Wataru; Miyamoto Yoshihiro; Kamakura Shiro; Matsuura Hiroshi; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• 1 Brugada Syndrome and Diverse Phenotypes of Cardiac Sodium Channelopathies(Symposium 5 (SY-05) (A) New Findings of Mechanism and Therapeutic Strategies of Idiopathic Ventricular Fibrillation,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Doi Takahiro; Oono Seiko; Nishio Yukiko; Oka Yuko; Tsuji Keiko; Itoh Hideki; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• PE-251 Mutation analysis of the Glycerol-3 Phosphate Dehydrogenase-1 Like (GPD1L) Gene in Japanese Patients with Brugada Syndrome(Arrhythmia, diagnosis/Pathophysiology/EPS(07)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Haruna Yoshisumi; Doi Takahiro; Oono Seiko; Nishio Yukiko; Tsuji Keiko; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• OE-391 Cardiac sodium channel gene mutations are prevalent in Japanese patients with familial sick sinus syndrome(Arrhythmia, diagnosis/Pathophysiology/EPS(02)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Oka Yuko; Doi Takahiro; Oono Seiko; Nishio Yukiko; Tsuji Keiko; Itoh Hideki; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• PJ-577 The targeting of cyclophilin D by RNA interference as a novel therapeutic strategy against myocardial ischemia/reperfusion injury(Acute coronary syndrome, basic/clinical(05)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Kato Masashi; Akao Masaharu; Makiyama Takeru; Matsumoto Madoka; Takeda Toshihiro; Iguchi Moritake; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• OJ-009 A Common KCNE1 Polymorphism, D85N, is a Genetic Modifier of Long QT Syndrome(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Nishio Yukiko; Yamamoto Satoshi; Makita Naomasa; Makiyama Takeru; Itoh Hideki; Sakaguchi Tomoko; Ohno Seiko; Akao Masaharu; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• Plakophilin-2 mutations are common in Japanese arrhythmogenic right ventricular cardiomyopathy

  NISHIO Y; Nagaoka Iori; Ishida Katsuya; Makiyama Takeru; Kajimoto Katsuya; Kasanuki Hiroshi; Kita Toru; Horie Minoru

  Circ J, 2008

  
• OJ-009 N- And C-terminal KCNE1 Mutations Cause Distinct Phenotypes of Long QT Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Ohno Seiko; Zankov Dimitar; Yoshida Hidetada; Tsuji Keiko; Makiyama Takeru; Itoh Hideki; Akao Masaharu; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• OJ-007 Variable Genetic Backgrounds Between Congenital and Acquired Long-QT Syndromes(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Itoh Hideki; Makiyama Takeru; Oono Seiko; Tsuji Keiko; Oka Yuko; Sakaguchi Tomoko; Nagaoka Iori; Nakazawa Yuko; Yao Takenori; Ashihara Takashi; Ito Makoto; Akao Masaharu; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• PJ-125 Targeting Cyclophilin D by RNA Interference Inhibits Oxidant-Induced Mitochondrial Death Pathway in Cardiac Myocytes(Myocardial ischemia/reperfusion, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Kato Masashi; Akao Masaharu; Makiyama Takeru; Matsumoto Madoka; Takeda Toshihiro; Iguchi Moritake; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• FRS-078 Spectrum and Prevalence of Cardiac Sodium Channel (SCN5A) Mutations in a Cohort of 194 Unrelated Patients Referred for Inherited Arrhythmias(Arrhythmia (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Haruna Yoshisumi; Tsuji Keiko; Doi Takahiro; Oono Seiko; Nishio Yukiko; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• OE-081 Mechanistic Basis for the Pathogenesis of Long QT Syndrome Associated with a Common Splicing Mutation in KCNQ1 Gene(Arrhythmia, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Tsuji Keiko; Akao Masaharu; Ishii Takahiro; Ohno Seiko; Makiyama Takeru; Doi Takahiro; Haruna Yoshisumi; Nishio Yukiko; Yoshida Hidetada; Nakashima Toshihiro; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• PJ-043 Clinical Characteristics for Japanese Patients with Genotyped Long-QT Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Oka Yuko; Makiyama Takeru; Itoh Hideki; Oono Seiko; Sakaguchi Tomoko; Nagaoka Iori; Ashihara Takashi; Ito Makoto; Akao Masaharu; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• PJ-046 Genotype-Phenotype Correlations of KCNJ2 Mutations in Japanese Patients with Andersen-Tawil Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-10, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

  Haruna Yoshisumi; Makiyama Takeru; Kobon Atsushi; Yoshida Hidetada; Doi Takahiro; Tsuji keiko; Oono Seiko; Nishio Yukiko; Akao Masaharu; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

  
• Phenotypical Gender Difference in Two Genotypes of Familial Long QT Syndrome Patients

  Ono Seiko; Takenaka Kotoe; Ohtani Hideo; Ninomiya Tomonori; Kobori Atsushi; Makiyama Takeru; Shimizu Wataru; Kamakura Shiro; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

  
• Influence of balloon pressure after Raidus stent deployment on long-term angiographic outcome

  KATAOKA K; Nakashima Yasuhiro; Katoh Takao; Horie Takahiro; Nagao Kazuya; Makiyama Takeru; Hoshino Kouzou; Miyamoto Tadashi; Takatsu Yoshiki

  Cir J, 2004

  
• Molecular and Genetic Basis for the Treatment of Long QT-Related Lethal Ventricular Arrhythmias

  Horie Minoru; Takenaka Kotoe; Ootani Hideo; Ninomiya Tomonori; Kobori Atsushi; Oono Seiko; Makiyama Takeru; Shimizu Wataru; Kamakura Shiro

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

  
• ECG Findings in Andersen's Syndrome : Action Potential Simulation Study

  Kobori Atsushi; Sarai Nobuaki; Matsuoka Satoshi; Oono Seiko; Makiyama Takeru; Takenaka Kotoe; Ninomiya Tomonori; Noma Akinori; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

  
• Quantitative Analysis of Aberrant Splicing Caused by a Splice-site Mutation in KCNQ1 Gene of a Patient with Long QT Syndrome (Genetics/Genetically Engineered Models (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Tsuji Keiko; Akao Masaharu; Ishii Takahiro; Oono Seiko; Makiyama Takeru; Kobori Atsushi; Takenaka Kotoe; Doi Takahiro; Yoshida Hidetada; Kiyohara Yoshikazu; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

  
• High-risk for Bradyarrhythmic Complications in Patients with Brugada Syndrome Caused by SCN5A Gene Mutations(Arrhythmia, Basic (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Tsuji Keiko; Doi Takahiro; Oono Seiko; Takenaka kotoe; Yoshida Hidetada; Yanagisawa Fumiko; Takano Makoto; Makita Naomasa; Higashi Yukei; Takeyama Yoichi; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

  
• SCN5A Gene Silencing by Adenovirus-mediated Short Interfering RNA Delivery in Neonatal Rat Ventricular Myocytes(Arrhythmia, Basic 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Doi Takahiro; Takeda Toshihiro; Tsuji Keiko; Matsumoto Madoka; Takenaka Kotoe; Oono Seiko; Yoshida Hidetada; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

  
• OJ-064 Age-Related Triggers for Life-Threatening Arrhythmia in Genotyped Long-QT Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-3 (A) OJ11,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Sakaguchi Tomoko; Itoh Hideki; Yamamoto Satoshi; Nagaoka Iori; Yoshida Hidetada; Oono Seiko; Makiyama Takeru; Akao Masaharu; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

  
• 1 Genotype-Phenotypes Relations of SCN5A-Positive Brugada Syndrome(Brugada Syndrome:From Cell to Bedside,Plenary Session 2 (PL2) (A),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Itoh Hideki; Makiyama Takeru; Yoshida Hidetada; Akao Masaharu; Makita Naomasa; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

  
• OJ-349 High Incidence of Cardiac Events for Long-QT Syndrome with Compound Mutations(Arrhythmia, diagnosis/pathophysiology/EPS-4 (A) OJ59,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Itoh Hideki; Sakaguchi Tomoko; Yamamoto Satoshi; Nagaoka Iori; Makiyama Takeru; Yoshida Hidetada; Ohno Seiko; Tsuji Keiko; Akao Masaharu; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

  
• PJ-190 A KCNE1 Single Nucleotide Polymorphism, D85N, Serves as a Modifier in Forme-fruste Type of Long QT syndrome(Genetics/Genetically engineered models/Gene therapy-3 (M) PJ32,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Yamamoto Satoshi; Itoh Hideki; Sakaguchi Tomoko; Nagaoka Iori; Yoshida Hidetada; Oono Seiko; Makiyama Takeru; Akao Masaharu; Makita Naomasa; Shimizu Wataru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

  
• NRDC regulates sinus automaticity through transcriptional regulation of ionchannels

  大野美紀子; 松浦博; 牧山武; 糀谷泰彦; 西清人; 松田真太郎; 木村剛; 西英一郎

  日本循環薬理学会口演要旨集, 2021

  
• 小児期遺伝性不整脈疾患の睡眠中突然死予防に関する研究 先天性QT延長症候群における遺伝子検査の有用性に関する研究

  清水渉; 相庭武司; 堀江稔; 野上昭彦; 蒔田直昌; 宮本恵宏; 牧山武; 森田宏; 中野由紀子; 林研至; 岩崎雄樹; 村田広茂

  小児期遺伝性不整脈疾患の睡眠中突然死予防に関する研究 平成30年度 総括・分担研究報告書(Web), 2019

  
• PJ-571 Multiple Mechanisms underlie Long QT Syndrome by the Change of Amino Acid R259 in the Intracellular S4-S5 Linker of KCNQ1(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Ohno Seiko; Yoshida Hidetada; Tsuji keiko; Makiyama Takeru; Doi Takahiro; Nishio Yukiko; Hattori Tetsuhisa; Akao Masaharu; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• PE-106 SCN5A and Lamin A/C Gene Mutations are Highly Prevalent in Patients with Familial Bradyarrhythmic Disorders(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Shizuta Satoshi; Doi Takahiro; Oono Seiko; Nishio Yukiko; Hattori Tetsuhisa; Tsuji Keiko; Itoh Hideki; Kimura Takesi; Yokode Masayuki; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• PE-104 Severer Phenotypes of Long QT Syndrome are Associated with Compound Mutations : A Multicenter Study(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Itoh Hideki; Shimizu Wataru; Yamagata Kenichiro; Sakaguchi Tomoko; Oono Seiko; Makiyama Takeru; Akao Masaharu; Noda Takashi; Miyamoto Yoshihiro; Kamakura Shiro; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• OE-162 The Impact of CYP2C19 Polymorphism on the Antiplatelet Effect of Clopidogrel in the Real Clinical Setting(OE28,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Jinnai Toshikazu; Horiuchi Hisanori; Nagai Kouzou; Tazaki Junichi; Tada Tomohisa; Makiyama Takeru; Touma Masanao; Tamura Toshihiro; Kita Toru; Kimura Takesi

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• 2 Latent Genetic Backgrounds and Molecular Pathogenesis of Drug-induced Long QT Syndrome(Proarrhythmic Risk of Drugs and Their Evaluation,Symposium 7 (SY-07) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Itoh Hideki; Watanabe Eiichi; Watanabe Ichiro; Sakaguchi Tomoko; Makiyama Takeru; Akao Masaharu; Oono Seiko; Zenda Naoko; Higashi Yukei; Mori Chikara; Okajima Katsunori; Matsuura Hiroshi; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• 1 A Novel Genetic Marker for Potential Risk of QT Prolongation and Cardiac Sudden Death : KCNE1-D85N Polymorphism(Biomarkers, Genetic Polymorphism, and Risk Estimation,Symposium 1 (SY-01) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Nishio Yukiko; Itoh Hideki; Makiyama Takeru; Sakaguchi Tomoko; Oono Seiko; Akao Masaharu; Matsuura Hiroshi; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• FRS-052 Identification and Functional Characterization of a Novel Intronic Splicing Mutation in KCNQ1 Associated with Long QT Syndrome(FRS11,New Insights into Basic Mechanisms of Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Tsuji Keiko; Akao Masaharu; Ishii Takahiro; Ashihara Takashi; Makiyama Takeru; Ohno Seiko; Toyoda Futoshi; Nishio Yukiko; Sakaguchi Tomoko; Matsuura hiroshi; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009

  
• Multi-layer Cardiac Pacemaker Mechanisms demonstrated in Human Induced Pluripotent Stem Cells by Developing Mathematical Cell Models

  KOHJITANI Hirohiko; KODA Shigeya; HIMENO Yukiko; MAKIYAMA Takeru; YAMAMOTO Yuta; WURIYANGHAI Yimin; YOSHINAGA Daisuke; KASHIWA Asami; AMANO Akira; NOMA Akinori; KIMURA Takeshi

  Journal of Physiological Sciences (Web), 2020

  
• CACNA1C-E1115K Mutation Associated with Overlap Phenotype of Long-QT and Brugada Syndrome Disrupts Cav 1.2 Ion Selectivity in Patient-specific iPS Cell-derived Cardiomyocytes

  KASHIWA Asami; MAKIYAMA Takeru; KOHJITANI Hirohiko; MAURISSEN Thomas; WURIYANGHAI Yimin; YAMAMOTO Yuta; GAO Jingshan; HUANG Hai; IMAMURA Tomohiko; AIZAWA Takanori; ISHIKAWA Taisuke; OHNO Seiko; TOYODA Futoshi; SATO Seiich; TAKAHASHI Kazuhiro; WOLTJEN Knut; HORIE Minoru; MAKITA Naomasa; KIMURA Takeshi

  Journal of Physiological Sciences (Web), 2020

  
• Metalloprotease nardilysin controls heart rate through the transcriptional regulation of ion channels critical for sinus automaticity.

  Ohno Mikiko; Matsuura Hiroshi; Makiyama Takeru; Kojitani Hirohiko; Nishi Kiyoto; Iwasaki Hirotaka; Matsuda Shintaro; Kimura Takeshi; Nishi Eiichiro

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020

  
• Calmodulinopathy(カルモジュリン遺伝子関連不整脈疾患) iPS細胞技術を用いた疾患モデルの作製と遺伝子治療へのアプローチ

  山本 雄大; 牧山 武

  心電図, Dec. 2019

  
• Morphological and Electrophysiological Characterization of Homozygous Lamin A/C Knockout Human Induced-Pluripotent Stem Cell-Derived Cardiomyocytes

  Yimin Wuriyanghai; Takeru Makiyama; Yuta Yamamoto; Hirohiko Kohjitani; Sayako Hirose; Jingshan Gao; Asami Kashiwa; Hai Huang; Takanori Aizawa; Tomohiko Imamura; Seiko Ohno; Minoru Horie; Takeshi Kimura

  CIRCULATION, Nov. 2019

  
• Genetic variants of alcohol-metabolizing enzymes in Brugada syndrome: Insights into syncope after drinking alcohol

  Qi Wu; Hideki Hayashi; Daiki Hira; Keiko Sonoda; Satoshi Ueshima; Seiko Ohno; Takeru Makiyama; Tomohiro Terada; Toshiya Katsura; Katsuyuki Miura; Minoru Horie

  Journal of Arrhythmia, 01 Oct. 2019, Peer-reviewed

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• 失神の診断と治療 心原性、致死性不整脈疾患の鑑別 特に遺伝性不整脈疾患に関して

  牧山 武

  てんかん研究, Sep. 2019

  
• 心臓電気生理を理解して不整脈診療に活かす 8 ヒトiPS細胞由来心筋細胞の電気生理学

  堀江稔; YIMIN Wuriyanghai; 牧山武

  Heart View, 09 Jun. 2019

  
• 【心臓電気生理を理解して不整脈診療に活かす】識る ヒトiPS細胞由来心筋細胞の電気生理学

  堀江 稔; Wuriyanghai Yimin; 牧山 武

  Heart View, Jun. 2019

  
• iPS cell-derived cardiomyocytes as a platform for research on inherited arrhythmias

  堀江 稔; Wuriyanghai Yimin; 牧山 武

  Heart view, Jun. 2019

  
• ヒトiPS由来分化心筋の数理モデルを用いた細胞特異的な活動電位波形の再現とI_Kr電流遮断シミュレーションによる反応性の検討

  糀谷泰彦; 幸田茂也; 姫野友紀子; 牧山武; 木村剛; 野間昭典; 天野晃

  心電図, 20 Mar. 2019

  
• 学校心臓検診の問題点と課題・金沢宣言も踏まえて 心電図による学校検診プログラムにおけるQT延長症候群の遺伝学的スクリーニングの有用性(Usefulness of Genetic Screening for Long QT Syndrome in the School-Based Electrocardiographic Screening Programs)

  福山 恵; 大野 聖子; 小澤 淳一; 高山 幸一郎; 加藤 浩一; 伊藤 英樹; 青木 寿明; 牧山 武; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2019

  
• 先天性QT延長症候群の遺伝的および臨床的特徴 日本の多施設共同レジストリの結果(Genetics and Clinical Aspects of Congenital Long-QT Syndrome: Results from the Japanese Multicenter Registry)

  清水 渉; 山形 研一郎; 野田 崇; 草野 研吾; 宮崎 文; 牧山 武; 伊藤 英樹; 大野 聖子; 渡部 裕; 林 研至; 森田 宏; 吉永 正夫; 福田 恵一; 宮本 恵宏; 鎌倉 史郎; 田中 敏博; 住友 直方; 萩原 誠久; 蒔田 直昌; 堀江 稔; 相庭 武司

  日本循環器学会学術集会抄録集, Mar. 2019

  
• ヒトiPS由来分化心筋の数理モデルを用いた細胞特異的な活動電位波形の再現とIKr電流遮断シミュレーションによる反応性の検討

  糀谷 泰彦; 幸田 茂也; 姫野 友紀子; 牧山 武; 木村 剛; 野間 昭典; 天野 晃

  心電図, Mar. 2019

  
• 学校心臓検診の問題点と課題・金沢宣言も踏まえて(Usefulness of Genetic Screening for Long QT Syndrome in the School-Based Electrocardiographic Screening Programs)

  福山 恵; 大野 聖子; 小澤 淳一; 高山 幸一郎; 加藤 浩一; 伊藤 英樹; 青木 寿明; 牧山 武; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2019

  
• Genetics and Clinical Aspects of Congenital Long-QT Syndrome: Results from the Japanese Multicenter Registry(和訳中)

  清水 渉; 山形 研一郎; 野田 崇; 草野 研吾; 宮崎 文; 牧山 武; 伊藤 英樹; 大野 聖子; 渡部 裕; 林 研至; 森田 宏; 吉永 正夫; 福田 恵一; 宮本 恵宏; 鎌倉 史郎; 田中 敏博; 住友 直方; 萩原 誠久; 蒔田 直昌; 堀江 稔; 相庭 武司

  日本循環器学会学術集会抄録集, Mar. 2019

  
• Modeling Overlapping Phenotypes of Long-QT and Brugada Syndrome with CACNA1C-E1115K that Alters Ion Selectivity of the Cardiac L-Type Calcium Channel Using Induced Pluripotent Stem Cells

  KASHIWA Asami; MAKIYAMA Takeru; KOHJITANI Hirohiko; WURIYANGHAI Yimin; YAMAMOTO Yuta; GAO Jingshan; HUANG Hai; ISHIKAWA Taisuke; OHNO Seiko; TOYODA Futoshi; SATO Seiichi; HORIE Minoru; MAKIYA Naomasa; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2019

  
• Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-Associated RyR2 Mutant Channels Using a Three-Dimensional In Silico Model

  GAO Jingshan; MAKIYAMA Takeru; OHNO Seiko; YAMAMOTO Yuta; WURIYANGHAI Yimin; KOHJITANI Hirohiko; KASHIWA Asami; HAI Huang; KATOU Kouichi; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2019

  
• 経皮的ASD閉鎖術の術前・術後に経皮的カテーテル心筋焼灼術を施行した1例

  糀谷泰彦; 静田聡; 中井久登; 田中宗和; 山上新太郎; 相澤卓範; 小正晃裕; 吉澤尚志; 牧山武; 木村剛

  日本不整脈心電学会カテーテルアブレーション委員会公開研究会プログラム・抄録集, 2019

  
• Metalloprotease nardilysin controls heart rate through the transcriptional regulation of ion channels critical for sinus automaticity

  Ohno Mikiko; Matsuura Hiroshi; Makiyama Takeru; Iwasaki Hirotaka; Matsuda Shintaro; Nishi Eiichiro

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019

  
• Recent advances in inherited arrhythmias research studies using iPS cell technology

  牧山 武; 山本 雄大

  循環器内科 = Cardioangiology, Dec. 2018

  
• More- vs. Less-Intensive Lipid Lowering Therapy: Systematic Review and a Meta-Analysis.

  Toshiaki Toyota; Takeshi Morimoto; Yugo Yamashita; Hiroki Shiomi; Takao Kato; Takeru Makiyama; Yasuaki Nakagawa; Naritatsu Saito; Satoshi Shizuta; Koh Ono; Takeshi Kimura

  CIRCULATION, Nov. 2018

  
• iPS細胞心筋を用いたQT延長症候群3型への診断利用

  吉永 大介; 馬場 志郎; 松田 浩一; 赤木 健太郎; 平田 拓也; 牧山 武; 西小森 隆太

  日本小児循環器学会雑誌, Jul. 2018

  
• Brugada症候群における飲酒後失神に寄与するscore systemの構築

  呉き; 平大樹; 林秀樹; 園田佳子; 大野聖子; 牧山武; 寺田智祐; 堀江稔

  心電図, 12 Mar. 2018

  
• Brugada症候群における飲酒後失神に寄与するscore systemの構築

  呉き; 平大樹; 林秀樹; 園田佳子; 大野聖子; 牧山武; 寺田智祐; 堀江稔

  心電図, 12 Mar. 2018

  
• CALM2関連性QT延長症候群iPSCモデルにおいて、l-cis-diltiazemは遅延したL型calciumチャネルの不活性化をさらに強める(l-cis-Diltiazem Enhances Slowed L-type Calcium Channel Inactivation in CALM2-associated Long-QT Syndrome iPSC Model)

  横井 文香; 牧山 武; 山本 雄大; 張田 健志; Wuriyanghai Yimin; 早野 護; 西内 英; 糀谷 泰彦; 廣瀬 紗也子; 高 景山; 大野 聖子; 豊田 太; 吉田 善紀; 蒔田 直昌; 堀江 稔; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2018

  
• 短連結性異型トルサードドポアント患者で同定されたSCN5A遺伝子変異の機能変化(Functional Change of SCN5A Mutations Identified in the Patients with Short-Coupled Variant of Torsades de Pointes)

  園田 桂子; 大野 聖子; 牧山 武; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2018

  
• 心臓突然死の病態解明と予知・予防 人工多能性幹細胞をベースにした遺伝性不整脈のモデリング(Induced Pluripotent Stem Cell-based Modeling of Inherited Arrhythmias)

  牧山 武

  日本循環器学会学術集会抄録集, Mar. 2018

  
• 実診療における静脈血栓塞栓症に対する抗凝固療法 COMMAND VTEレジストリから(Anticoagulation Therapy for Venous Thromboembolism in the Real World: From COMMAND VTE Registry)

  山下 侑吾; 森本 剛; 天野 秀生; 高瀬 徹; 平森 誠一; 金 基泰; 赤尾 昌治; 小林 洋平; 大井 磨紀; 多田 朋弥; 陳 博敏; 村田 耕一郎; 露木 義章; 佐賀 俊介; 笹 智樹; 坂本 二郎; 山田 千夏; 塩見 紘樹; 牧山 武; 尾野 亘; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2018

  
• CALM2関連性QT延長症候群iPSCモデルにおいて、l-cis-diltiazemは遅延したL型calciumチャネルの不活性化をさらに強める(l-cis-Diltiazem Enhances Slowed L-type Calcium Channel Inactivation in CALM2-associated Long-QT Syndrome iPSC Model)

  横井 文香; 牧山 武; 山本 雄大; 張田 健志; Wuriyanghai Yimin; 早野 護; 西内 英; 糀谷 泰彦; 廣瀬 紗也子; 高 景山; 大野 聖子; 豊田 太; 吉田 善紀; 蒔田 直昌; 堀江 稔; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2018

  
• SCN5A-D1275N関連性心筋ナトリウムチャネロパチーのヒトiPSC由来心筋細胞モデルから、蛋白質分解の亢進によってナトリウム電流が低下することが判明した(Human iPSC-Derived Myocyte Model of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting from Enhanced Protein Degradation)

  早野 護; 牧山 武; 鎌倉 令; 渡部 裕; 伊敏 烏日揚海; 西内 英; 張田 健志; 山本 雄大; 糀谷 泰彦; 廣瀬 紗也子; 横井 文香; 大野 聖子; 豊田 太; 吉田 善紀; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2018

  
• 短連結性異型トルサードドポアント患者で同定されたSCN5A遺伝子変異の機能変化(Functional Change of SCN5A Mutations Identified in the Patients with Short-Coupled Variant of Torsades de Pointes)

  園田 桂子; 大野 聖子; 牧山 武; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2018

  
• Cell-specific Precise Computer Simulation of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test

  KOHJITANI Hirohiko; KOUDA Shigeya; HIMENO Yukiko; MAKIYAMA Takeru; YOKOI Fumika; HIROSE Sayako; WURIYANGHAI Yimin; YAMAMOTO Yuta; HORIE Minoru; KIMURA Takeshi; NOMA Akinori; AMANO Akira

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2018

  
• 心筋炎に合併した房室ブロックの1例

  中川大志; 田中宗和; 牧山武; 加藤貴雄; 木村剛

  日本循環器学会近畿地方会(Web), 2018

  
• 活動性がんを有する患者に見つかった無症候性の下肢深部静脈血栓症の診療実態と予後

  山下侑吾; 塩見紘樹; 森本剛; 米田智也; 山田千夏; 牧山武; 加藤貴雄; 齋藤成達; 静田聡; 尾野亘; 木村剛

  心臓, 2018

  
• ラミノパチー患者に対する両室再同期療法は心不全予後を改善させるか?

  中島健三郎; 相庭武司; 西内英; 牧山武; 尾上健児; 鎌倉令; 和田暢; 石橋耕平; 岡村英夫; 大野聖子; 宮本恵宏; 斎藤能彦; 堀江稔; 清水渉; 草野研吾

  日本心臓病学会学術集会(Web), Sep. 2017

  
• ラミノパチー患者に対する両室再同期療法は心不全予後を改善させるか?

  中島健三郎; 相庭武司; 西内英; 牧山武; 尾上健児; 鎌倉令; 和田暢; 石橋耕平; 岡村英夫; 大野聖子; 宮本恵宏; 斎藤能彦; 堀江稔; 清水渉; 草野研吾

  日本心臓病学会学術集会(Web), Sep. 2017

  
• iPS細胞心筋を用いたQT延長症候群への診断利用

  吉永 大介; 馬場 志郎; 柴田 洋史; 平田 拓也; 牧山 武; 平家 俊男

  日本小児循環器学会雑誌, Jul. 2017

  
• 表現型・治療方針が異なったSCN5A compound mutationの1家系

  星野健司; 小川潔; 菱谷隆; 河内貞貴; 斎藤千徳; 馬場俊輔; 石川悟; 新田順一; 牧山武; 大野聖子; 堀江稔

  Therapeutic Research, 20 Apr. 2017

  
• Rare Single Nucleotide Polymorphism of SCN10A in Patients with Inherited Primary Arrhythmia Syndromes(和訳中)

  福山 恵; 大野 聖子; 市川 麻理; 牧山 武; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2017

  
• 心臓突然死の遺伝的背景 ブルガダ症候群におけるSCN5Aコピー数の多様性(Copy Number Variations of SCN5A in Brugada Syndrome)

  園田 桂子; 大野 聖子; 市川 麻理; 服部 哲久; 伊藤 英樹; 牧山 武; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2017

  
• Inherited primary arrhythmia syndrome患者におけるSCN10Aの稀な一塩基多型(Rare Single Nucleotide Polymorphism of SCN10A in Patients with Inherited Primary Arrhythmia Syndromes)

  福山 恵; 大野 聖子; 市川 麻理; 牧山 武; 堀江 稔

  日本循環器学会学術集会抄録集, Mar. 2017

  
• I-cis-diltiazem rescues impaired calcium channel inactivation in an iPSC-model of CACNA1C-associated long-QT syndrome

  HARITA Takeshi; MAKIYAMA Takeru; TOYODA Futoshi; SASAKI Kenichi; NISHIUCHI Suguru; HAYANO Mamoru; YAMAMOTO Yuta; KOHJITANI Hirohiko; WURIYANGHAI Yimin; HIROSE Sayako; CHEN Jiarong; FUKUYAMA Megumi; CHONABAYASHI Kazuhisa; OHNO Seiko; YOSHIDA Yoshinori; UEYAMA Takeshi; SHIMIZU Akihiko; MATSUURA Hiroshi; HORIE Minoru; KIMURA Takeshi

  Journal of Physiological Sciences, 2017

  
• Modelling Long-QT Syndrome Type 3 Associated with Near-Miss Sudden Infant Death Syndrome Using Human-Induced Pluripotent Stem Cells

  HIROSE Sayako; MAKIYAMA Takeru; MELGARI Dario; WU Jie; WU Jie; YOKOI Fumika; WURIYANGHAI Yimin; KOHJITANI Hirohiko; YAMAMOTO Yuta; NISHIUCHI Suguru; HAYANO Mamoru; HARITA Takeshi; YOSHIMOTO Jun; OHNO Seiko; YOSHIDA Yoshinori; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2017

  
• lL-cis-Diltiazem Ameliorates Impaired Calcium Channel Inactivation in a Patient-Specific Stem Cell Model of Long-QT Syndrome with a Calmodulin Mutation

  YOKOI Fumika; MAKIYAMA Takeru; HARITA Takeshi; YAMAMOTO Yuta; HAYANO Mamoru; NISHIUCHI Suguru; KOHJITANI Hirohiko; WURIYANGHAI Yimin; WURIYANGHAI Yimin; HIROSE Sayako; TOYODA Futoshi; YOSHIDA Yoshinori; MAKITA Naomasa; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2017

  
• CARDIAC RYANODINE RECEPTOR CHANNELOPATHY

  M. Horie; S. Ohno; Y. Wada; H. Itoh; Y. Fujii; K. Dochi; M. Kawamura; K. Hasegawa; K. Sasaki; T. Makiyama

  CARDIOLOGY, 2017

  
• Cardiomyopathy Caused by Right Free-Wall Accessory Pathway

  Yasuhiro Sasaki; Mamoru Hayano; Naoaki Onishi; Mituhiko Yahata; Kentarou Nakai; Aiko Haraguti; Kouji Gotou; Takahiro Doi; Takeru Makiyama; Satoshi Shizuta; Takeshi Kimura

  journal of arrhythmia, 2017, Peer-reviewed

  
• S状中隔に伴う高度の左室流出路狭窄が疑われるも,正確な圧較差測定に難渋した一例

  玉内華子; 山上新太郎; 森内健史; 渡部宏俊; 小笹寧子; 牧山武; 中川靖章; 齋藤成達; 木村剛

  日本循環器学会近畿地方会(Web), 2017

  
• 全身性強皮症に心アミロイドーシスを合併した1症例

  玉内華子; 今田一彰; 木下秀之; 北野一樹; 辰島正二郎; 柳澤洋; 森内健史; 今井逸雄; 齋藤成達; 牧山武; 中川靖章; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2017

  
• 遺伝子診断に基づく不整脈疾患群の病態解明および診断基準・重症度分類・ガイドライン作成に関する研究

  牧山武

  遺伝子診断に基づく不整脈疾患群の病態解明および診断基準・重症度分類・ガイドライン作成に関する研究 平成28年度 総括研究報告書(Web), 2017

  
• 集学的治療が奏功した閉塞性肥大型心筋症の1例

  横田瞭; 吉田雅晴; 小正晃裕; 齋藤成達; 牧山武

  日本循環器学会近畿地方会(Web), 2017

  
• 感染性心内膜炎による大動脈弁破壊から急性心不全をきたした一例~感染性心内膜炎における手術時期の検討~

  筒井偉宝; 吉田雅晴; 牧山武; 斎藤成逹; 木村剛

  日本循環器学会近畿地方会(Web), 2017

  
• 初期診断が困難であったたこつぼ心筋症の一例

  高田知和; 辻村朗; 牧山武

  日本循環器学会近畿地方会(Web), 2017

  
• 肺動脈性肺高血圧症に対する肺移植術後急性期における左室および右室機能の評価

  米田智也; 木下秀之; 木下秀之; 中島康弘; 中島康弘; 本山秀樹; 土屋恭子; 青山晃博; 陳豊史; 中川靖章; 柳澤洋; 牧山武; 静田聡; 桑原宏一郎; 木村剛; 伊達洋至; 一山智

  日本心臓病学会学術集会(Web), Sep. 2016

  
• Copy number variations in SCN5A associated with Brugada syndrome

  K. Sonoda; S. Ohno; J. Ozawa; M. Hayano; H. Ito; T. Makiyama; M. Horie

  EUROPEAN HEART JOURNAL, Aug. 2016

  
• A novel CACNA1C mutation identified in a patient with atypical Timothy syndrome exerts both loss- and gain-of-function effects on Cav1.2

  J. Ozawa; S. Ohno; F. Toyoda; M. Fukuyama; T. Harita; T. Makiyama; H. Saitoh; H. Suzuki; A. Saitoh; H. Matsuura; M. Horie

  EUROPEAN HEART JOURNAL, Aug. 2016

  
• l-cis diltiazem rescues impaired calcium channel inactivation in a patient-specific stem cell model of long QT syndrome with a CACNA1C mutation

  T. Harita; T. Makiyama; F. Toyoda; S. Nishiuchi; M. Hayano; Y. Yamamoto; Y. Wuriyanghai; H. Kohjitani; S. Ohno; Y. Yoshida; T. Ueyama; S. Yamanaka; A. Shimizu; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2016

  
• Triple mutations in three major genes for long QT syndrome are very rare and cause complicated phenotypes with ventricular arrhythmia

  S. Ohno; J. Wu; Y. Mizusawa; K. Sonoda; H. Itoh; T. Makiyama; M. Horie

  EUROPEAN HEART JOURNAL, Aug. 2016

  
• イオンチャンネル病の遺伝子検査の有用性

  星野 健司; 小川 潔; 菱谷 隆; 菅本 健司; 河内 貞貴; 細谷 通靖; 馬場 俊輔; 堀江 稔; 大野 聖子; 牧山 武

  日本小児循環器学会雑誌, Jul. 2016

  
• 膠原病関連肺高血圧症とCT所見

  柳澤洋; 柳澤洋; 木下秀之; 吉藤元; 半田知宏; 藤井隆夫; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 三森経世; 木村剛

  呼吸と循環, 15 May 2016

  
• 小児QT延長症候群:LQT2は発症年齢が高いが重症例が多い

  小澤淳一; 大野聖子; 伊藤英樹; 堀江稔; 大野聖子; 小澤淳一; 牧山武

  滋賀医学, 20 Mar. 2016

  
• Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation

  HAYANO Mamoru; MAKIYAMA Takeru; SASAKI Kenichi; KAMAKURA Tsukasa; WURIYANGHAI Yimin; CHEN Jiarong; NISHIUCHI Suguru; HARITA Takeshi; YAMAMOTO Yuta; KOHJITANI Hirohiko; HIROSE Sayako; OHNO Seiko; TOYODA Futoshi; WATANABE Hiroshi; YOSHIDA Yoshinori; HORIE Minoru; KIMURA Takeshi

  Circulation Journal, 2016

  
• The Phenotype in Cardiomyocytes Derived from Induced Pluripotent Stem Cells of Long QT Syndrome Type 8 Patients without Extracardiac Phenotypes

  HARITA Takeshi; MAKIYAMA Takeru; SASAKI Kenichi; NISHIUCHI Suguru; HAYANO Mamoru; YAMAMOTO Yuta; KOHJITANI Hirohiko; HIROSE Sayako; JIARONG Chen; WURIYANGHAI Yimin; FUKUYAMA Megumi; TOYODA Futoshi; OHNO Seiko; YOSHIDA Yoshinori; UEYAMA Takeshi; SHIMIZU Akihiko; HORIE Minoru; KIMURA Takeshi

  Circulation Journal, 2016

  
• Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation

  HAYANO Mamoru; MAKIYAMA Takeru; SASAKI Kenichi; KAMAKURA Tsukasa; WURIYANGHAI Yimin; NISHIUCHI Suguru; HARITA Takeshi; YAMAMOTO Yuta; KOHJITANI Hirohiko; HIROSE Sayoko; OHNO Seiko; YOYODA Futoshi; WATANABE Hirohi; YOSHIDA Yoshinori; YAMANAKA Shinya; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2016

  
• Patient-Specific Induced Pluripotent Stem-Cell Models for Long QT Syndrome with the Missense Mutation in the KCNH2 Gene

  KOHJITANI Hirohiko; MAKIYAMA Takeru; SASAKI Kenichi; HIROSE Sayako; NISHIUCHI Suguru; HAYANO Mamoru; HARITA Takeshi; YAMAMOTO Yuta; WURIYANGHAI Yimin; OHNO Seiko; HORIE Minoru; KIMURA Takeshi

  日本不整脈心電学会学術大会プログラム・抄録集(Web), 2016

  
• 植込み型除細動器(ICD)適応に難渋したBrugada症候群疑いの1例

  吉治智志; 山上新太郎; 相澤卓範; 川治徹真; 吉澤尚志; 杉山裕章; 齋藤成達; 牧山武; 静田聡; 木村剛

  日本循環器学会近畿地方会(Web), 2016

  
• 特発性心筋症に関する調査研究―ラミンA/C遺伝子関連心筋症の解析―

  木村剛; 牧山武

  特発性心筋症に関する調査研究 平成27年度 総括分担研究報告書, 2016

  
• 遺伝子診断に基づく不整脈疾患群の病態解明および診断基準・重症度分類・ガイドライン作成に関する研究 LMNA関連心筋症における性差,変異部位の検討

  牧山武

  遺伝子診断に基づく不整脈疾患群の病態解明および診断基準・重症度分類・ガイドライン作成に関する研究 平成27年度 総括研究報告書, 2016

  
• CALM遺伝子変異によるQT延長症候群の患者由来iPS細胞を用いた疾患モデルにおける変異アレル特異的ノックアウトによる治療的アプローチ

  山本雄大; 牧山武; 張田健志; 佐々木健一; 早野護; 西内英; ウリヤンハイ イミン; 糀谷泰彦; 廣瀬紗也子; チン カヨウ; 石川泰輔; 大野聖子; 蝶名林和久; 吉田善紀; 堀江稔; 蒔田直昌; 木村剛

  日本分子生物学会年会プログラム・要旨集(Web), 2016

  
• カテコラミン誘発性多形性心室頻拍の重症化に関与する遺伝な修飾因子の解明

  長谷川奏恵; 長谷川奏恵; 大野聖子; 大野聖子; 伊藤英樹; 芦原貴司; 牧山武; 堀江稔

  心臓, 2016

  
• 免疫抑制下の高齢者に生じた水痘再感染の1例

  影本善子; 藤井弘子; 太田千尋; 牧山武; 藤澤章弘; 谷岡未樹; 宮地良樹

  皮膚科の臨床, 01 Nov. 2015

  
• Brugada症候群の高齢患者における電気除細動器植え込みに関する必要性の評価(Evaluation of the Necessity for Cardioverter-defibrillator Implantation in Elderly Patients with Brugada Syndrome)

  鎌倉 令; 和田 暢; 中島 育太郎; 石橋 耕平; 宮本 康二; 岡村 英夫; 野田 崇; 相庭 武司; 高木 洋; 安田 聡; 小川 久雄; 清水 渉; 牧山 武; 木村 剛; 鎌倉 史郎; 草野 研吾

  日本心臓病学会学術集会抄録, Sep. 2015

  
• 肺血管拡張薬中止理由の検討と病棟専従薬剤師の役割の考察

  吉田優子; 木下秀之; 吉田詩織; 木下美津子; 中川靖章; 牧山武; 静田聡; 桑原宏一郎; 木村剛; 松原和夫

  呼吸と循環, 15 Aug. 2015

  
• 肺高血圧症合併肺ランゲルハンス細胞組織球症に対する治療経過

  柳澤洋; 木下秀之; 山田徹; 半田知宏; 中川靖章; 牧山武; 静田聡; 桑原宏一郎; 伊達洋至; 木村剛

  呼吸と循環, 15 Aug. 2015

  
• 心筋再生の現状と展望 ヒトiPS細胞由来心筋細胞の長期培養における成熟化

  牧山武; 鎌倉令; 鎌倉令

  最新医学, 10 Aug. 2015

  
• Abnormal expression of cardiac ion channels-associated genes in lamin A/C-related cardiomyopathy-specific induced pluripotent stem cell derived cardiomyocytes

  S. Nishiuchi; T. Makiyama; K. Sasaki; Y. Kohjitani; S. Ohno; Y. Yoshida; T. Doi; S. Shizuta; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2015

  
• Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction

  J. Chen; T. Makiyama; Y. Wuriyanghai; S. Ohno; T. Ueyama; A. Shimizu; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2015

  
• Ultrastructural Maturation of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes in a Long-term Culture

  牧山 武; 鎌倉 令

  最新医学, Aug. 2015

  
• 運動時における失神症例からのカテコラミン誘発性多形性心室頻拍症例の抽出

  小澤淳一; 小澤淳一; 大野聖子; 大野聖子; 藤居祐介; 牧山武; 鈴木博; 齋藤昭彦; 堀江稔

  日本小児循環器学会雑誌, 16 Jul. 2015

  
• 外傷後16年を経過し診断・治療に至ったtraumatic TRの1症例

  米田智也; 土井孝浩; 牧山武; 木下秀之; 坂口仁寿; 平尾慎吾; 南方謙二; 木村剛; 坂田隆造; 一山智

  超音波医学, 15 Apr. 2015

  
• 若年性心房細動患者に同定されたカリウムチャネル変異

  長谷川奏恵; 大野聖子; 芦原貴司; 伊藤英樹; 堀江稔; 牧山武

  滋賀医学, 20 Mar. 2015

  
• 循環器疾患 3.カテコラミン誘発性多形性心室頻拍における疾患特異的iPS細胞を用いた研究

  牧山武

  遺伝子医学MOOK, 05 Feb. 2015

  
• 【iPS細胞を用いた難病研究-臨床病態解明と創薬に向けた研究の最新知見】 (第3章)循環器疾患 カテコラミン誘発性多形性心室頻拍における疾患特異的iPS細胞を用いた研究

  牧山 武

  遺伝子医学MOOK, Feb. 2015

  
• Validation of Multifunction CardioGram (MCG) in screening of Coronary Atherosclerosis

  川治徹真; 塩見紘樹; 西川隆介; 矢野真理子; 樋上裕起; 田崎淳一; 今井逸雄; 斎藤成達; 牧山武; 静田聡; 尾野亘; 木村剛

  臨床医薬, 30 Jan. 2015

  
• Electrophysiological Properties of L-type Calcium Channels in Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes

  HARITA Takeshi; MAKIYAMA Takeru; SASAKI Kenichi; HAYANO Mamoru; NISHIUCHI Suguru; YAMAMOTO Yuta; KOHJITANI Hirohiko; CHEN Jiarong; WURIYANGHAI Yimin; OHNO Seiko; ITO Hideki; YOSHIDA Yoshinori; HORIE Minoru; KIMURA Takeshi

  Circulation Journal, 2015

  
• Genetic Backgrounds of Patients with Clinically Diagnosed Idiopathic Ventricular Fibrillation

  KOHJITANI Hirohiko; MAKIYAMA Takeru; SASAKI Kenichi; OHNO Seiko; WURIYANGHAI Yimin; HAYANO Mamoru; NISHIUCHI Suguru; YAMAMOTO Yuta; HARITA Takeshi; KIMURA Takeshi; HORIE Minoru

  Circulation Journal, 2015

  
• 肺動脈性肺高血圧症における肺移植術後急性期の左室機能の検討

  米田智也; 木下秀之; 中島康弘; 本山秀樹; 土屋恭子; 青山晃博; 陳豊史; 柳沢洋; 山田千夏; 今井逸雄; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 伊達洋至; 一山智; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• ICD移植後,頻回のVF,ICD作動が起こった若年J波症候群の一例

  橋本健太郎; 八幡光彦; 岡林真梨恵; 辰島正二郎; 藤田啓誠; 笹智樹; 柳沢洋; 川治徹真; 樋上裕起; 塩見紘樹; 中井健太郎; 渡部宏俊; 田崎淳一; 杉山裕章; 今井逸雄; 齋藤成達; 牧山武; 土井孝浩; 静田聡; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 持続性心房細動に対してNifekalantを用いたCFAEアブレーションが有効であった一例

  川治徹真; 八幡光彦; 中井健太郎; 牧山武; 静田聡; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 肺高血圧症を早期に発見できた間質性肺炎合併多発性筋炎の1症例

  脊古裕太; 木下秀之; 柳沢洋; 藤井隆夫; 半田知宏; 山田千夏; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 原因不明の左心機能低下を背景に持ち,心室細動から蘇生した1症例

  水野良祐; 岡林真梨恵; 川治徹真; 田崎淳一; 齋藤成達; 静田聡; 牧山武; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 心房細動に対する冷凍アブレーションが奏功した一例~当院における初期40症例の治療成績とともに~

  ホームズ彩乃; 杉山裕章; 静田聡; 的場芳樹; 川治徹真; 中井健太郎; 牧山武; 齋藤成達; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• ワルファリン及びエドキサバンに不耐性を示した再発性深部静脈血栓症(DVT)にアピキサバンを使用した一例

  池田圭佑; 杉山裕章; 今井逸雄; 牧山武; 齋藤成達; 木下秀之; 静田聡; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 化学療法が著効した結核性収縮性心膜炎の一例

  米田智也; 牧山武; 矢野真理子; 土井孝浩; 木村剛; 一山智

  日本心エコー図学会学術集会抄録集, 2015

  
• 遺伝性不整脈疾患の診断基準・重症度分類・診療ガイドライン等の作成に関する研究 ラミンA/C遺伝子関連心筋症の病態解析

  牧山武

  遺伝性不整脈疾患の診断基準・重症度分類・診療ガイドライン等の作成に関する研究 平成26年度 総括・分担研究報告書, 2015

  
• 遺伝性心血管疾患における集中的な遺伝子解析及び原因究明に関する研究「エピネフリン負荷QT延長症例にて検出されたSCN5A遺伝子C末変異の機能解析」

  木村剛; 牧山武

  遺伝性心血管疾患における集中的な遺伝子解析及び原因究明に関する研究 平成26年度 委託業務成果報告書, 2015

  
• ARVD様心形態を示した亜急性心筋炎の一例

  牧山武; 川路徹真; 小笹寧子; 静田聡; 桑原宏一郎; 的場芳樹; 高橋衛; 木村剛

  日本血管生物医学会学術集会プログラム・抄録集, 2015

  
• 肺移植待機中の肺動脈性肺高血圧症患者における予後予測指標の検討

  山上新太郎; 木下秀之; 本山秀樹; 土屋恭子; 青山晃博; 陳豊史; 辻村郎; 柳澤洋; 山田千夏; 牧山武; 中川靖章; 靜田聡; 桑原宏一郎; 尾野亘; 伊達洋至; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 非アルコール性脂肪肝炎に合併したと考えられる門脈圧亢進症性肺動脈性肺高血圧症の1症例

  辰島正二郎; 木下秀之; 柳沢洋; 川治徹真; 山田千夏; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 不整脈原性右室心筋症が疑われた右室拡大を伴う急性心筋炎の一例

  田代結; 川治徹真; 小笹寧子; 牧山武; 静田聡; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 血液透析施行中の末期腎不全に合併した肺高血圧症に対し肺血管拡張薬を投与した1症例

  家村知樹; 山田千夏; 木下秀之; 辰島正二郎; 小笹寧子; 渡部宏俊; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 気腫合併肺線維症に合併した高度肺高血圧に対し肺血管拡張療法を行った1症例

  岡林真梨恵; 木下秀之; 相澤卓範; 半田知宏; 室繁郎; 山田千夏; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2015

  
• 乳児の致死性不整脈と心臓チャネル病の関連について

  加藤浩一; 牧山武; WU Jie; DING Wei‐Guang; 木村紘美; 内貴乃生; 大野聖子; 伊藤英樹; 中西敏雄; 松浦博; 堀江稔

  福田記念医療技術振興財団情報, Dec. 2014

  
• 国際交流 実績報告 乳児の致死性不整脈と心臓チャネル病の関連について

  加藤 浩一; 牧山 武; Wu Jie

  福田記念医療技術振興財団情報, Dec. 2014

  
• 後天性QT延長症候群の遺伝的背景:多施設国際共同研究

  伊藤英樹; CROTTI Lia; 相庭武司; DENJOY Isabelle; FRESSART Veronique; 林研至; 中島忠; 大野聖子; 牧山武; 山岸正和; BERTHET Myriam; 清水渉; GUICHENEY Pascale; SCHWARTZ; Peter J; 堀江稔

  日本心臓病学会学術集会抄録(CD-ROM), 02 Sep. 2014

  
• 家族性の完全房室ブロックに重症心不全を合併し左室補助装置またはトリバプタンを用いたラミノパチーの2症例

  坂田鋼治; 漆間雅人; 平野秀治; 長友美達; 竹永誠; 相庭武司; 牧山武; 肥後太基; 清水渉

  日本心臓病学会学術集会抄録(CD-ROM), 02 Sep. 2014

  
• 肺動脈性肺高血圧症患者に対する最新の治療を考える

  木下秀之; 柳澤洋; 山田千夏; 中川靖章; 牧山武; 静田聡; 桑原宏一郎; 木村剛

  日本心臓病学会学術集会抄録(CD-ROM), 02 Sep. 2014

  
• High frequency of ANK2 mutations in patients with non-genotyped primary inherited arrhythmia syndromes

  S. Ohno; M. Fukuyama; H. Itoh; T. Makiyama; M. Horie

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• Recapitulation of lamin A/C-related cardiomyopathy using patient-specific induced pluripotent stem cells: a novel splicing mutation in LMNA gene

  S. Nishiuchi; T. Makiyama; K. Sasaki; Y. Wuriyanghai; Y. Yoshida; S. Ono; T. Aiba; W. Shimizu; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• Cardiac sodium channel gene mutations associated with dilated cardiomyopathy

  M. Hayano; T. Makiyama; K. Sasaki; Y. Yamamoto; T. Harita; S. Nishiuchi; Y. Wuriyanghai; S. Ohno; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• A novel SCN4B intronic variant identified in patients with Brugada syndrome and idiopathic ventricular fibrillation caused an exon skipping

  Q. Wang; S. Ohno; M. Fukuyama; K. Sasaki; T. Makiyama; M. Horie

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• Identification of novel SCN10A variants in Brugada syndrome patients

  M. Fukuyama; S. Ohno; T. Makiyama; K. Hasegawa; H. Itoh; M. Horie

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• Novel abnormal splicing variants identified in induced pluripotent stem cell-derived cardiomyocytes from a long-QT syndrome patient with KCNQ1-A344A

  Y. Wuriyanghai; T. Makiyama; K. Sasaki; Y. Yoshida; S. Ohno; K. Watanabe; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• Identification of latent mutations in primary inherited arrhythmia syndromes using benchtop next generation sequencer

  S. Ohno; M. Fukuyama; H. Itoh; T. Makiyama; M. Horie

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• Association of pre-infarction angina and total ischemic time with long-term survival in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

  T. Taniguchi; H. Shiomi; T. Toyota; T. Makiyama; S. Shizuta; T. Morimoto; Y. Furukawa; Y. Nakagawa; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• 循環器診療の最前線と心臓リハビリテーション 肺動脈性肺高血圧症患者に対する最新の治療を考える

  木下 秀之; 柳澤 洋; 山田 千夏; 中川 靖章; 牧山 武; 静田 聡; 桑原 宏一郎; 木村 剛

  日本心臓病学会学術集会抄録, Sep. 2014

  
• 家族性の完全房室ブロックに重症心不全を合併し左室補助装置またはトルバプタンを用いたラミノパチーの2症例

  坂田 鋼治; 漆間 雅人; 平野 秀治; 長友 美達; 竹永 誠; 相庭 武司; 牧山 武; 肥後 太基; 清水 渉

  日本心臓病学会学術集会抄録, Sep. 2014

  
• 多機能プロテアーゼによる心拍数制御機構

  大野美紀子; 平岡義範; 松浦博; 西清人; 西城さやか; 坂本二郎; 陳博敏; 牧山武; 北徹; 木村剛; 西英一郎

  日本循環制御医学会総会プログラム・抄録集, Jul. 2014

  
• 第3回 重症肺高血圧症カンファレンス 症例提示‐3 肺野に異常陰影の出現を認めた特発性肺動脈性肺高血圧症の1症例

  木下秀之; 柳澤洋; 西川隆介; 中川靖章; 牧山武; 桑原宏一郎; 木村剛

  心臓, 15 Jun. 2014

  
• 遺伝性不整脈の診断とマネージメント―三大陸不整脈学会Expert Consensus Statementを踏まえて―Expert Consensus Statementを踏まえた遺伝性不整脈の診断とマネージメント iPS細胞を用いた遺伝性不整脈の病態解明とテーラーメイド治療

  牧山武

  Card Pract, 30 Apr. 2014

  
• 二枝ブロックを伴う意識消失症例に植込み型ループレコーダーを移植したところ,洞不全症候群が指摘された1例

  八幡光彦; 静田聡; 早野護; 中井健太郎; 後藤貢士; 土井孝浩; 牧山武; 木村剛

  心電図, 17 Mar. 2014

  
• 致死性不整脈症候群の病態解明に関する研究 臨床・基礎研究(ヒト疾患特異的人工多能性幹(iPS)細胞を用いた解析)

  木村 剛; 北 徹; 堀江 稔; 堀内 久徳; 尾野 亘; 牧山 武; 吉田 善紀

  医科学応用研究財団研究報告, Feb. 2014

  
• 致死性不整脈症候群の病態解明に関する研究―臨床・基礎研究(ヒト疾患特異的人工多能性幹(iPS)細胞を用いた解析)

  木村剛; 北徹; 堀江稔; 堀内久徳; 尾野亘; 牧山武; 吉田善紀

  医科学応用研究財団研究報告(CD-ROM), Feb. 2014

  
• 診断に苦慮した原発性三尖弁閉鎖不全症の一例

  大塚悠生; 西川隆介; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 高安動脈炎経過中に急性心筋炎を発症した一例

  栗山優香; 渡部宏俊; 木下秀之; 今井逸雄; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 発作性上室性頻拍(PSVT)に対するカテーテル・アブレーション後に失神で発症した肺血栓塞栓症(PTE)の一例

  小口綾貴子; 杉山裕章; 牧山武; 静田聡; 田崎淳一; 渡部宏俊; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 拡張相肥大型心筋症の慢性腎不全に対し左室補助循環装置の植込み術を施行した64歳男性の一例

  辰島正二郎; 西川隆介; 小笹寧子; 牧山武; 南方謙二; 坂田隆造; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• めまいの精査過程で診断された心室頻拍(VT)にカテーテル・アブレーションが有効であった若年女性の一例

  岡田圭次郎; 杉山裕章; 静田聡; 牧山武; 小笹寧子; 井出裕也; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 血管肉腫による収縮性心膜炎様の病態をきたした1症例

  小椋淳平; 木下秀之; 川治徹真; 桑原佳宏; 中川靖章; 牧山武; 桑原宏一郎; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 先天性右肺動脈欠損を伴う肺高血圧症に僧帽弁逆流症・心房細動を合併し,集学的治療を施行した1例

  笹智樹; 桑原佳宏; 田崎淳一; 木下秀之; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• Becker型筋ジストロフィ合併拡張型心筋症

  川治徹真; 今井逸雄; 小笹寧子; 齋藤成達; 牧山武; 静田聡; 尾野亘; 塩井哲雄; 木村剛; 中根武一郎; 南方謙二; 坂田隆造

  日本循環器学会近畿地方会(Web), 2014

  
• 間質性肺炎を合併した強皮症関連肺動脈性高血圧症に対しPGI2持続静注療法を施行した1症例

  柳澤洋; 木下秀之; 西川隆介; 桑原佳宏; 中川靖章; 牧山武; 桑原宏一郎; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• サルコイドーシスに合併した肺高血圧症の一例

  沼尚吾; 木下秀之; 辰島正二郎; 樋上裕起; 牧山武; 桑原宏一郎; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 慢性血栓塞栓性肺高血圧症(CTEPH)に対しバルーン肺動脈形成術(BPA)が奏功し子宮体癌根治術を施行し得た1例

  藤野赳至; 渡邉真; 木下秀之; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 左心耳内の広範囲CFAE焼灼が有効であった長期持続性心房細動の一例

  八幡光彦; 静田聡; 岡林真梨恵; 辰島正二郎; 藤田啓誠; 笹智樹; 柳澤洋; 川治徹真; 中井健太郎; 杉山裕章; 齋藤成達; 牧山武; 土井孝浩; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 重症の造影剤アレルギー既往を有する徐脈頻脈症候群に対して造影剤未使用下のアブレーションにより心房細動(AF)の根治に成功した1例

  杉山裕章; 静田聡; 川治徹真; 中井健太郎; 八幡光彦; 土井孝浩; 牧山武; 木村剛

  日本不整脈学会カテーテルアブレーション委員会公開研究会プログラム・抄録集, 2014

  
• 心室二重応答を介して房室リエントリー性頻拍(AVRT)が誘発された顕在性WPW症候群の一例

  相澤卓範; 杉山裕章; 静田聡; 牧山武; 齋藤成達; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• レフレル心内膜炎の一例

  辰島正二郎; 樋上裕起; 山田千夏; 田崎淳一; 今井逸雄; 木下秀之; 齋藤成達; 牧山武; 中川靖章; 静田聡; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• CRT‐D創部感染に対してエキシマ・レーザにてリード全抜去を行ったラミン関連心筋症の一例

  川口雄亮; 八幡光彦; 土井孝浩; 静田聡; 岡林真梨恵; 辰島正二郎; 藤田啓誠; 笹智樹; 柳澤洋; 川治徹真; 樋上裕起; 塩見紘樹; 中井健太郎; 渡部宏俊; 杉山裕章; 田崎淳一; 渡邉真; 今井逸雄; 齋藤成達; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 多機能プロテアーゼによる洞房結節自動能制御機構

  大野美紀子; 松浦博; 平岡義範; 西清人; 西城さやか; 坂本二郎; 陳博俊; 牧山武; 北徹; 木村剛; 西英一郎

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• 膠原病関連肺高血圧症に対する早期発見による肺血管拡張薬治療効果の検討

  柳澤洋; 木下秀之; 山田千夏; 桑原佳宏; 中川靖章; 牧山武; 静田聡; 尾野亘; 塩井哲雄; 桑原宏一郎; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 左心耳(LAA)血栓の存在評価に腹臥位心臓CTが有用であった一例

  岡林真梨恵; 杉山裕章; 静田聡; 金尾昌太郎; 桑原康秀; 山田千夏; 牧山武; 齋藤成達; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2014

  
• 遺伝性不整脈疾患の遺伝子基盤に基づいた病態解明と診断・治療法の開発に関する研究 QT延長症候群1型スプライシング異常症例におけるヒトiPS細胞由来分化心筋細胞を用いた解析

  牧山武

  遺伝性不整脈疾患の遺伝子基盤に基づいた病態解明と診断・治療法の開発に関する研究 平成25年度 総括・分担研究報告書, 2014

  
• A case of Idiopathic Pulmonary Arterial Hypertension with abnormal lung lesions

  Kinoshita Hideyuki; Yanagisawa Hiromu; Nishikawa Ryusuke; Nakagawa Yasuaki; Makiyama Takeru; Kuwahara Koichiro; Kimura Takeshi

  Shinzo, 2014

  
• 若年時に診断された催不整脈性右室心筋症・異形成(ARVC/D)患者の臨床的および遺伝的特徴

  大野聖子; 福山恵; 長谷川奏恵; 木村紘美; 伊藤英樹; 牧山武; 堀江稔

  心電図, 11 Sep. 2013

  
• 著明な心機能低下および伝導障害を呈したSCN5A R1023C mutationの1例

  早野護; 牧山武; 八幡光彦; 山本雄大; 張田健志; 西内英; 鎌倉令; 佐々木健一; 大野聖子; 堀江稔; 木村剛

  心電図, 11 Sep. 2013

  
• アンダーセン症候群の予後―30歳以上で致死性不整脈を初発しうる―

  木村紘美; 伊藤英樹; 大野聖子; 内貴乃生; 福山恵; 加藤浩一; 長谷川奏恵; 牧山武; 伊藤誠; 堀江稔

  心電図, 11 Sep. 2013

  
• iPS細胞由来の不整脈疾患モデル心筋細胞

  牧山武; 佐々木健一; 鎌倉令; 吉田善紀; 堀江稔; 木村剛

  心電図, 11 Sep. 2013

  
• iPS細胞の臨床応用 現状と展望 iPS細胞由来の不整脈疾患モデル心筋細胞

  牧山 武; 佐々木 健一; 鎌倉 令; 吉田 善紀; 堀江 稔; 木村 剛

  心電図, Sep. 2013

  
• ヒトiPS細胞由来分化誘導心筋細胞の電気生理学的および組織学的特徴と疾患特異的iPS細胞を用いた遺伝性心疾患研究

  牧山武

  心電図, 19 Aug. 2013

  
• Copy number variations in KCNQ1 gene were frequently identified in the pediatric patients of long QT syndrome and caused exercise related QT prolongation

  S. Ohno; M. Fukuyama; H. Itoh; T. Makiyama; M. Horie

  EUROPEAN HEART JOURNAL, Aug. 2013

  
• 再生心筋の興奮発生と伝導および不整脈研究への応用 ヒトiPS細胞由来分化誘導心筋細胞の電気生理学的および組織学的特徴と疾患特異的iPS細胞を用いた遺伝性心疾患研究

  牧山 武

  心電図, Aug. 2013

  
• 致死性不整脈診療 各論 家族性徐脈症候群

  牧山武

  最新医学, 10 Jul. 2013

  
• 【致死性不整脈診療の最前線】 致死性不整脈診療 家族性徐脈症候群

  牧山 武

  最新医学, Jul. 2013

  
• Genetic Background of Bradyarrhythmic Disorders

  牧山 武

  最新医学, Jul. 2013

  
• 【イオンチャネル病のすべて】 QT短縮症候群

  牧山 武

  医学のあゆみ, Jun. 2013

  
• QT延長症候群における遺伝子検査の有用性

  星野健司; 小川潔; 菱谷隆; 菅本健司; 斎藤千徳; 藤本義隆; 堀江稔; 大野聖子; 牧山武

  日本小児循環器学会雑誌, 01 Jun. 2013

  
• QT短縮症候群

  牧山武

  医学のあゆみ, 01 Jun. 2013

  
• Short QT syndrome

  牧山 武

  医学のあゆみ, 01 Jun. 2013

  
• 低用量アミオダロンの有用性と副作用の検討

  大西尚昭; 静田聡; 太田千尋; 佐々木康博; 八幡光彦; 中井健太郎; 後藤貢士; 土井孝浩; 牧山武; 尾野亘; 塩井哲雄; 木村剛; 貝谷和昭; 泉知里; 中川義久

  Prog Med, 29 Mar. 2013

  
• アンダーセン症候群の表現型の多様性について

  木村紘美; 周潤; 伊藤英樹; 水澤有香; 川村美朋子; 宮本証; 川口民郎; 内貴乃生; 大野聖子; 伊藤誠; 堀江稔; 松浦博; 牧山武

  滋賀医学, 20 Mar. 2013

  
• Beta-blocker was not Associated with Improved 5-year Clinical Outcome in Patients with Chronic Kidney Disease after ST-elevation Acute Myocardial Infarction．

  Neiko Ozasa

  第78回日本心臓循環器学会（東京）, Mar. 2013

  
• 進行性心臓伝導障害に心機能低下を合併した心臓Naチャネル病の1家系

  牧山武; 静田聡; 土井孝浩; 八幡光彦; 佐々木健一; 鎌倉令; 大野聖子; 伊藤英樹; 堀江稔; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 大動脈弁穿孔を来したベラパミル感受性心室頻拍に対して治療が成功した一例

  八幡光彦; 静田聡; 川治徹真; 西川隆介; 矢野真理子; 太田千尋; 樋上裕起; 守上裕子; 宝蔵麗子; 中井健太郎; 田崎淳一; 今井逸雄; 齋藤成達; 土井孝浩; 西山慶; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 発作性夜間ヘモグロビン尿症に伴う血栓症に対して,ワルファリンとエクリズマブ投与が有効であった一例

  森村祐樹; 西川隆介; 田崎淳一; 牧山武; 木村剛; 川端浩

  日本循環器学会近畿地方会(Web), 2013

  
• 著明な左室流出路圧格差を認めショックに至ったたこつぼ心筋症

  川治徹真; 宝蔵麗子; 今井逸雄; 尾野亘; 塩井哲雄; 牧山武; 静田聡; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 特発性間質性肺炎による肺高血圧症に対して,肺高血圧治療薬を用いて心機能改善を認めた一例

  西川隆介; 宝蔵麗子; 牧山武; 木村剛; 木下秀之; 青山晃博

  日本循環器学会近畿地方会(Web), 2013

  
• 胸部大動脈瘤に対してステントグラフト内挿術施行後に脳塞栓および下肢動脈塞栓を起こした1例

  田崎淳一; 樋上裕起; 西川隆介; 今井逸雄; 齋藤成達; 川東正英; 丸井晃; 坂田隆造; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 膝窩動脈瘤破裂により急性下肢閉塞を来した一例

  岩井眞紗子; 樋上裕起; 田崎淳一; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 血管ベーチェット病を背景とした腎動脈瘤に対し血管内治療を施行した一例

  吉田卓矢; 樋上裕起; 守上裕子; 宝蔵麗子; 田崎淳一; 渡邉真; 今井逸雄; 齋藤成達; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 心室中隔穿孔を合併した蛸壷型心筋症の1例

  米田智也; 牧山武; 土井孝浩; 中尾哲史; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• Churg‐Strauss症候群において心機能障害をきたした一例

  大久保直紀; 守上裕子; 宝蔵麗子; 塩見紘樹; 夏秋政浩; 渡邉真; 田崎淳一; 今井逸雄; 齋藤成達; 牧山武; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 右肺静脈隔離中に横隔神経障害を生じた一例

  中井健太郎; 静田聡; 太田千尋; 八幡光彦; 後藤貢士; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 抗血小板剤中止に伴う遅発性ステント血栓症の一例:原因は薬剤溶出性ステントか?生体吸収性ステントか?

  塩見紘樹; 牧山武; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• カテコラミン感受性多形性心室頻拍に対し電気生理学検査,植込型除細動器移植術を施行した1例

  北野正之; 八幡光彦; 土井孝浩; 静田聡; 川治徹真; 西川隆介; 矢野真理子; 太田千尋; 樋上裕起; 守上裕子; 宝蔵麗子; 中井健太郎; 田崎淳一; 今井逸雄; 齋藤成達; 西山慶; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 腎動脈直下急性大動脈閉塞を合併したLeriche症候群に対して,血栓除去およびEVTにて血行再建に成功した一例

  大竹ひかり; 西川隆介; 田崎淳一; 丸井晃; 樋上裕起; 今井逸雄; 渡邉真; 齋藤成達; 牧山武; 木村剛; 坂田隆造

  日本循環器学会近畿地方会(Web), 2013

  
• ペースメーカーデバイス感染症に対しデバイス抜去術が必要となった2症例

  矢野真理子; 八幡光彦; 守上裕子; 土井孝浩; 静田聡; 川治徹真; 西川隆介; 太田千尋; 樋上裕起; 宝蔵麗子; 中井健太郎; 田崎淳一; 今井逸雄; 齋藤成達; 西山慶; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• Fallot四徴症根治術後の肺動脈再狭窄をきたした一例

  谷口雅司; 太田千尋; 静田聡; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 筋ジストロフィーが併存する心筋症の一例

  川平直史; 八幡光彦; 土井孝浩; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 内腸骨動脈瘤に対しコイル塞栓術施行後一過性脳虚血を認めた一例

  樋上裕起; 塩見紘樹; 田崎淳一; 今井逸雄; 齋藤成達; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• B型大動脈解離にたいして段階的に手術及びステントグラフト内挿術を施行し偽腔の完全血栓化が得られた1例

  田崎淳一; 西川隆介; 樋上裕起; 今井逸雄; 齋藤成達; 牧山武; 尾野亘; 塩井哲雄; 川東正英; 丸井晃; 坂田隆造; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• シロリムス溶出ステント留置後にPSSを生じOCTで観察した2症例

  内藤大輔; 今井逸雄; 塩見紘樹; 渡邉真; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 心室性不整脈を来した横隔膜原発横紋筋肉腫による心膜内播種の一例

  矢野真理子; 太田千尋; 今井逸雄; 牧山武; 静田聡; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 先天性QT延長症候群の家族内調査による遺伝的多様性の検討と治療指針の決定 疾患特異的ヒトiPS細胞を用いた遺伝性不整脈疾患の解析―カテコラミン誘発性多形性心室頻拍―

  牧山武

  先天性QT延長症候群の家族内調査による遺伝的多様性の検討と治療指針の決定 平成24年度 総括・分担研究報告書, 2013

  
• Hickmanカテーテル関連血流感染症に対し抗生剤ロック療法を行った1症例の検討

  廣田圭昭; 木下秀之; 山田千夏; 中尾一泰; 南丈也; 桑原佳宏; 保野慎治; 宇佐美覚; 中川靖章; 牧山武; 錦見俊雄; 上嶋健治; 桑原宏一郎; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• Leriche症候群に対してEVTにて血行再建に成功した一例

  西川隆介; 笹智樹; 田崎淳一; 今井逸雄; 渡邊真; 齋藤成達; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• Intramural hematomaに対してdebranch TEVARを施行した1例

  黒田悠規; 川治徹真; 樋上裕起; 田崎淳一; 牧山武; 木村剛; 南方謙二; 丸井晃; 坂田隆造

  日本循環器学会近畿地方会(Web), 2013

  
• 心室頻拍による心肺停止に対して蘇生後,CRT‐Dを移植した不整脈原性右室心筋症の一例

  八幡光彦; 齋藤成達; 川治徹真; 矢野真理子; 西川隆介; 樋上裕起; 中井健太郎; 田崎淳一; 杉山裕章; 今井逸雄; 小笹寧子; 牧山武; 土井孝浩; 静田聡; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 心室性不整脈を合併した閉塞性肥大型心筋症の一例

  八木俊純; 矢野真理子; 八幡光彦; 土井孝浩; 牧山武; 静田聡; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 非ストレス時に再発性失神発作を認めた先天性QT延長症候群(LQTS)の若年女性の一例

  高華; 杉山裕章; 牧山武; 静田聡; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• ダビガトラン(DBG)内服時のAPTT過延長を契機に診断された抗リン脂質抗体症候群(APS)の2例

  笹智樹; 杉山裕章; 静田聡; 早野護; 後藤貢士; 中井健太郎; 八幡光彦; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 意識消失の精査入院中に心室細動を発症し,埋込型除細動器を移植したJ波症候群の一例

  柳澤洋; 八幡光彦; 土井孝浩; 静田聡; 川治徹真; 西川隆介; 矢野真理子; 樋上裕起; 中井健太郎; 塩見紘樹; 田崎淳一; 杉山裕章; 渡邉真; 今井逸雄; 齋藤成達; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 両心室ペースメーカー(CRT‐P)植込み後に失神再発を認め,神経調節性失神(NMS)の関与が推察された1例

  辰島正二郎; 杉山裕章; 静田聡; 今井逸雄; 土井孝浩; 八幡光彦; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• ナルディライジンによる心拍数制御機構

  大野美紀子; 平岡義範; 松浦博; 西清人; 西城さやか; 坂本二郎; 陳博敏; 牧山武; 北徹; 木村剛; 西英一郎

  日本病態プロテアーゼ学会学術集会プログラム抄録集, 2013

  
• 高度大動脈弁狭窄症を原因とした急性左心不全に対しPTAVを施行した一例

  高木あかり; 樋上裕起; 今井逸雄; 齋藤成達; 田崎淳一; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 遺伝性不整脈疾患の遺伝子基盤に基づいた病態解明と診断・治療法の開発に関する研究 ヒトiPS細胞由来分化心筋細胞に関する長期培養による成熟化の検討

  牧山武

  遺伝性不整脈疾患の遺伝子基盤に基づいた病態解明と診断・治療法の開発に関する研究 平成24年度 総括・分担研究報告書, 2013

  
• 肺ランゲルハンス細胞組織球症に合併した肺高血圧症に対しエポプロステノールを使用した1症例

  波多腰桃子; 木下秀之; 西川隆介; 山田千夏; 中尾一泰; 南丈也; 桑原佳宏; 保野慎治; 宇佐美覚; 中川靖章; 牧山武; 錦見俊雄; 上嶋健治; 桑原宏一郎; 木村剛

  日本循環器学会近畿地方会(Web), 2013

  
• 外科的肺葉切除後患者に対する心房細動アブレーション―遺残肺静脈の不整脈原性と焼灼デザインに関する考察―

  杉山裕章; 静田聡; 八幡光彦; 中井健太郎; 原口愛子; 川治徹真; 早野護; 後藤貢士; 牧山武; 木村剛

  日本不整脈学会カテーテルアブレーション委員会公開研究会プログラム・抄録集, 2013

  
• 肺静脈隔離術の際,拡大した左心房において右肺静脈後壁に明確な横隔神経刺激が認められる領域が同定された1例

  八幡光彦; 静田聡; 原口愛子; 川治徹真; 中井健太郎; 杉山裕章; 後藤貢士; 牧山武; 土井孝浩; 木村剛

  日本不整脈学会カテーテルアブレーション委員会公開研究会プログラム・抄録集, 2013

  
• 1st sessionで大動脈弁穿孔を来したベラパミル感受性心室頻拍に対して2nd sessionおよび大動脈弁修復術を施行した1例

  八幡光彦; 静田聡; 原口愛子; 川治徹真; 中井健太郎; 杉山裕章; 後藤貢士; 牧山武; 土井孝浩; 木村剛

  日本不整脈学会カテーテルアブレーション委員会公開研究会プログラム・抄録集, 2013

  
• Eight-year follow-up after cardiac resynchronizing therapy of a patient with a mutation in lamin A/C—A case report—

  Ikeda Tomoyuki; Yoshihiro Himura; Horie Minoru; Makiyama Takeru; Nakao Tetsushi; Sugimoto Akira; Miyazawa Tsuyoshi; Geshi Toru; Nakano Akira; Ohashi Naohiro; Watanuki Masato

  Shinzo, 2013

  
• 薬剤性心毒性の臨床;薬剤性QT延長症候群/TdP

  牧山武

  臨床医薬, 28 Sep. 2012

  
• 特発性心室細動におけるL型カルシウムチャネル遺伝子異常

  福山恵; 大野聖子; WANG Qi; 木村紘美; 牧山武; 伊藤英樹; 伊藤誠; 堀江稔

  心電図, 10 Sep. 2012

  
• QT延長症候群合併Down症候群症例におけるSNaP shot法を用いたKCNE1‐D85Nアレル頻度の同定

  大野聖子; 高橋実穂; 福山恵; WANG Qi; 木村紘美; 伊藤英樹; 牧山武; 堀米仁志; 堀江稔

  心電図, 10 Sep. 2012

  
• 不整脈源性右室心筋症/異型性(ARVC/D)における年齢依存性の臨床および遺伝的特徴

  大野聖子; 西尾由貴子; 長岡伊織; 福山恵; 木村紘美; 伊藤英樹; 牧山武; 清水昭彦; 堀江稔

  日本心臓病学会誌, 06 Aug. 2012

  
• Novel CACNA1C mutations identified in Japanese patients caused both Brugada syndrome and Idiopathic Ventricular Fibrillation without QT shortening

  M. Fukuyama; S. Ohno; Q. Wang; H. Kimura; A. Miyamoto; T. Makiyama; H. Itoh; M. Itoh; M. Horie

  EUROPEAN HEART JOURNAL, Aug. 2012

  
• One-year assessment of ultrastructural changes in human induced pluripotent stem cell-derived cardiomyocytes

  T. Kamakura; T. Makiyama; K. Sasaki; T. Hattori; S. Ohno; Y. Yoshida; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2012

  
• 心血管疾患発症進展における遺伝・環境的要因 不整脈源性右室心筋症/異型性(ARVC/D)における年齢依存性の臨床および遺伝的特徴

  大野 聖子; 西尾 由貴子; 長岡 伊織; 福山 恵; 木村 紘美; 伊藤 英樹; 牧山 武; 清水 昭彦; 堀江 稔

  日本心臓病学会誌, Aug. 2012

  
• 後天性QT延長症候群の遺伝的背景と分子病態

  伊藤英樹; 坂口知子; 岡優子; 宮本証; 大野聖子; 牧山武; 林研至; 山岸正和; GUICHENEY Pascale; 堀江稔

  臨床薬理の進歩, 29 Jun. 2012

  
• ST上昇型急性心筋梗塞患者における心房細動の長期予後に及ぼす影響について

  中井健太郎; 静田聡; 原口愛子; 太田千尋; 佐々木康博; 大西尚昭; 八幡光彦; 後藤貢士; 牧山武; 土井孝浩; 木村剛

  J Arrhythmia, 28 May 2012

  
• QT延長症候群における変異遺伝子の伝達乖離―多施設国際共同研究―

  伊藤英樹; BERTHET Myriam; MAUGENRE Svetlana; GUICHENEY Pascale; DENJOY Isabelle; DIDIER Klug; 水澤由香; HOFMAN Nynke; WILDE Arthur; 牧山武; TEZENAS Sophie; SCHULZE‐BAHR Eric; 清水渉; 堀江稔

  J Arrhythmia, 28 May 2012

  
• 先天性QT延長症候群における遺伝子変異領域と予後・治療の選択

  相庭武司; 牧元久樹; 山形研一郎; 中島育太郎; 宮本康二; 山田優子; 岡村英夫; 野田崇; 里見和浩; 石原正治; 安斉俊久; 安田聡; 小川久雄; 鎌倉史郎; 宮本恵宏; 清水渉; 堀江稔; 小川聡; 相澤義房; 大江透; 草野研吾; 山岸正和; 蒔田直昌; 田中敏博; 牧山武; 吉永正夫; 萩原誠久; 住友直方

  J Arrhythmia, 28 May 2012

  
• 当院におけるダビガトランの使用経験

  太田千尋; 静田聡; 原口愛子; 大西尚昭; 佐々木康博; 八幡光彦; 中井健太郎; 後藤貢士; 牧山武; 土井孝浩; 木村剛

  J Arrhythmia, 28 May 2012

  
• 進行性心臓伝導障害の全国レジストリー

  蒔田直昌; 堀江稔; 清水渉; 住友直方; 関明子; 牧山武; 渡部裕; 赤星正純

  J Arrhythmia, 28 May 2012

  
• 上室性不整脈を合併した重症心不全患者に対する心臓再同期療法(CRT)とカテーテルアブレーション(RFCA)のハイブリッド治療の有効性

  八幡光彦; 土井孝浩; 静田聡; 早野護; 太田千尋; 大西尚昭; 佐々木康博; 中井健太郎; 後藤貢士; 牧山武; 木村剛

  J Arrhythmia, 28 May 2012

  
• 心房細動アブレーションにおける新規抗凝固薬ダビガトランの有効性と安全性について

  後藤貢士; 静田聡; 太田千尋; 原口愛子; 佐々木康博; 大西尚昭; 八幡光彦; 中井健太郎; 牧山武; 土井孝浩; 木村剛

  J Arrhythmia, 28 May 2012

  
• 植込み型ループレコーダーにより失神の原因確定に至った1症例

  吉田雅昭; 清水昭彦; 加藤孝佳; 福田昌和; 平塚淳史; 大宮俊秀; 土居正浩; 上山剛; 牧山武; 堀江稔; 松崎益徳

  心電図, 18 May 2012

  
• 遺伝性不整脈の臨床from bench to bedside 進行性心臓伝導障害の全国レジストリー

  蒔田 直昌; 堀江 稔; 清水 渉; 住友 直方; 関 明子; 牧山 武; 渡部 裕; 赤星 正純; Japanese PCCD registry

  Journal of Arrhythmia, May 2012

  
• 遺伝性不整脈の臨床from bench to bedside 先天性QT延長症候群における遺伝子変異領域と予後・治療の選択

  相庭 武司; 牧元 久樹; 山形 研一郎; 中島 育太郎; 宮本 康二; 山田 優子; 岡村 英夫; 野田 崇; 里見 和浩; 石原 正治; 安斉 俊久; 安田 聡; 小川 久雄; 鎌倉 史郎; 宮本 恵宏; 清水 渉; 堀江 稔; 小川 聡; 相澤 義房; 大江 透; 草野 研吾; 山岸 正和; 蒔田 直昌; 田中 敏博; 牧山 武; 吉永 正夫; 萩原 誠久; 住友 直方; 先天性QT延長症候群多施設登録研究

  Journal of Arrhythmia, May 2012

  
• 遺伝性不整脈の臨床from bench to bedside QT延長症候群における変異遺伝子の伝達乖離 多施設国際共同研究

  伊藤 英樹; Berthet Myriam; Maugenre Svetlana; Guicheney Pascale; Denjoy Isabelle; Didier Klug; 水澤 由香; Hofman Nynke; Wilde Arthur; 牧山 武; Tezenas Sophie; Schulze-Bahr Eric; 清水 渉; 堀江 稔

  Journal of Arrhythmia, May 2012

  
• 奇異な左室菲薄化を呈した心ファブリー病の一例

  米田智也; 牧山武; 土井孝浩; 徳重明央; 石井暁美; 岩田邦子; 元田博子; 山本将司; 木村剛

  超音波医学, 15 Apr. 2012

  
• 難治性高血圧に対してPTRAを施行した1例

  守上裕子; 多田朋弥; 今井逸雄; 牧山武; 塩井哲雄; 木村剛

  Ther Res, 20 Jan. 2012

  
• 進行性心臓伝導障害の病態診断と遺伝子基盤に関する研究 家族性徐脈疾患における疾患特異的ヒトiPS細胞を用いた解析

  牧山武

  進行性心臓伝導障害の病態診断と遺伝子基盤に関する研究 平成23年度 総括・分担研究報告書, 2012

  
• 当科に入院となった高齢心不全患者における生活機能障害の特徴

  吉田路子; 荻田美穂子; 小笹寧子; 鮑炳元; 小野原明子; 武田真寿美; 宇都宮宏子; 柿木良介; 南角学; 牧山武; 塩井哲雄; 木村剛; 荒井秀典

  日本心臓リハビリテーション学会学術集会プログラム抄録集(Web), 2012

  
• 慢性心房細動を合併する拡張相肥大型心筋症に対し,アブレーションと心臓再同期療法を施行した一例

  西川隆介; 八幡光彦; 土井孝浩; 静田聡; 川治徹真; 矢野真理子; 太田千尋; 樋上裕起; 守上裕子; 宝蔵麗子; 中井健太郎; 田崎淳一; 今井逸雄; 齋藤成達; 西山慶; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 左心系のMSSA感染性心内膜炎にseptic pulmonary embolismを併発した一例

  川治徹真; 大西尚昭; 尾野亘; 牧山武; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 右心不全を来した右室形態異常の一例

  矢野真理子; 守上裕子; 牧山武; 今井逸雄; 土井孝浩; 小笹寧子; 齋藤成達; 静田聡; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 奇異な左室菲薄化を呈した心ファブリー病の一例

  米田智也; 牧山武; 土井孝浩; 徳重明央; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 81歳で不整脈源性右室心筋症と診断された一例

  薗誠; 太田千尋; 小笹寧子; 静田聡; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 失神を来した閉塞性肥大型心筋症に対しシベンゾリンとペーシングにて左室流出路狭窄の改善を認めた一例

  八幡光彦; 静田聡; 早野護; 太田千尋; 樋上裕起; 大西尚昭; 佐々木康博; 守上裕子; 東谷暢也; 宝蔵麗子; 中井健太郎; 田崎淳一; 今井逸雄; 齋藤成達; 西山慶; 土井孝浩; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 心臓再同期療法へのgrade upの際,閉塞した鎖骨下静脈に対する側副血行路を通して左室リードを留置した一例

  八幡光彦; 土井孝浩; 静田聡; 川治徹真; 西川隆介; 矢野真理子; 太田千尋; 樋上裕起; 守上裕子; 宝蔵麗子; 中井健太郎; 田崎淳一; 今井逸雄; 齋藤成達; 西山慶; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• CTガイド下肺生検施行中に空気塞栓が原因で発症した急性心筋梗塞の一例

  軍司大悟; 塩見紘樹; 土井孝浩; 川治徹真; 樋上裕起; 守上裕子; 田崎淳一; 今井逸雄; 齋藤成達; 牧山武; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• WPW症候群を合併したEbstein奇形に対し,カテーテルアブレーションを施行した一例

  白神桃子; 八幡光彦; 静田聡; 川治徹真; 西川隆介; 矢野真理子; 太田千尋; 樋上裕起; 守上裕子; 宝蔵麗子; 中井健太郎; 田崎淳一; 今井逸雄; 齋藤成達; 土井孝浩; 西山慶; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 胸部ステントグラフト内挿術後,急性腸管虚血を発症した一例

  西川隆介; 樋上裕起; 守上裕子; 宝蔵麗子; 田崎淳一; 今井逸雄; 渡邉真; 齋藤成達; 牧山武; 木村剛; 川東正英; 丸井晃; 南方謙二; 坂田隆造

  日本循環器学会近畿地方会(Web), 2012

  
• 上室性頻拍を伴う左房瘤に対して外科的介入をした一例

  川治徹真; 太田千尋; 今井逸雄; 齋藤成達; 土井孝浩; 小笹寧子; 尾野亘; 塩井哲雄; 仲原隆弘; 山崎和裕; 南方謙二; 静田聡; 牧山武; 坂田隆造; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 人工弁置換術後の僧帽弁狭窄症に対してPTMCを施行した一例

  濱谷康弘; 齋藤成達; 夏秋政浩; 田崎淳一; 今井逸雄; 牧山武; 尾野亘; 塩井哲雄; 井上寛治; 木村剛

  日本循環器学会近畿地方会(Web), 2012

  
• 先天性QT延長症候群の家族内調査による遺伝的多様性の検討と治療指針の決定 カテコラミン誘発性多形性心発頻拍における疾患特異的ヒトiPS細胞を用いた解析

  牧山武

  先天性QT延長症候群の家族内調査による遺伝的多様性の検討と治療指針の決定 平成23年度 総括・分担研究報告書, 2012

  
• Disease-specific iPS cells to explore the pathological mechanisms of cardiovascular diseases

  牧山 武

  循環器内科, Nov. 2011

  
• Over-expression of heterozygous KCNJ2-M301K channels, identified in a patient with short QT syndrome, shortened action potential durations in neonatal rat ventricular myocytes

  T. Hattori; T. Makiyama; M. Akao; E. Ehara; S. Ohno; M. Iguchi; K. Sasaki; H. Itoh; M. Horie; T. Kimura

  EUROPEAN HEART JOURNAL, Aug. 2011

  
• Phenotype variability in patients carrying KCNJ2 mutations

  H. Kimura; J. Zhou; H. Itoh; Y. Mizusawa; A. Miyamoto; M. Kawamura; T. Makiyama; M. Ito; H. Matsuura; M. Horie

  EUROPEAN HEART JOURNAL, Aug. 2011

  
• CYP2C19遺伝子多型がクロピドグレル(ADP受容体拮抗薬)の抗血小板作用に及ぼす影響―日本人患者における検討―

  牧山武; 陣内俊和; 堀内久徳; 北徹, 木村剛

  臨床薬理の進歩, 20 Jun. 2011

  
• カテコラミン誘発性多形性心室頻拍症(CPVT)を疑う患者における遺伝子変異の検討―心筋リアノジン受容体(RyR2)について―

  川村美朋子; 木村紘美; 宮本証; 水澤有香; 地藤優子; 石田勝也; 伊藤英樹; 伊藤誠; 堀江稔; 牧山武; 大野聖子; 西尾由貴子

  滋賀医学, 20 Mar. 2011

  
• 両室ペーシングが奏効したLamin A/C遺伝子異常心筋症患者の長期経過を観察し得た1例

  池田智之; 中尾哲史; 椙本晃; 宮澤豪; 綿貫正人; 日村好宏; 牧山武; 木村剛; 堀江稔

  滋賀医学, 20 Mar. 2011

  
• Phenotype variability in patients carrying KCNJ2 mutations

  H. Kimura; J. Zhou; H. Itoh; Y. Mizusawa; A. Miyamoto; M. Kawamura; T. Makiyama; M. Ito; H. Matsuura; M. Horie

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011

  
• Efficacy and Safety of Intravenous Venous Amiodarone: A Single Center Experience

  Naoaki Onishi; Satoshi Shizuta; Aiko Haraguchi; Chihiro Ota; Yasuhiro Sasaki; Mitsuhiko Yahata; Kentarou Nakai; Kouji Gotou; Takeshi Makiyama; Takahiro Doi; Takeshi Kimura

  journal of arrhythmia, 2011, Peer-reviewed

  
• Clinical and Genetic Features of Japanese Patient with Congenital Long QT Syndrome

  Hisaki Makimoto; Takeshi Aiba; Shiro Kamakura; Yoshihiro Miyamoto; Wataru Shimizu; Minoru Horie; Satoshi Ogawa; Yoshifusa Aizawa; Tohru Ohe; Masakazu Yamgagishi; Naomasa Makita; Takeru Makiyama

  journal of arrhythmia, 2011, Peer-reviewed

  
• Clinical Features and Genetic Basis of Progressive Cardiac Conduction Defect: Japanese PCCD Registry

  Naomasa Makita; Takeru Makiyama; Hiroshi Watanabe; Akiko Seki; Naokata Sumitomo; Wataru Shimizu; Minoru Horie; Akihiko Nogami

  journal of arrhythmia, 2011, Peer-reviewed

  
• Mutation Analysis of the KCNJ8 Gene in Japanese Patients with J-Wave Syndrome and Idiopathic Ventricular Fibrillation

  Wang Qi; Seiko Ohno; Takeru Makiyama; Hiromi Kimura; Nobu Naiki; Mihoko Kawamura; Koichi Kato; Minoru Horie

  journal of arrhythmia, 2011, Peer-reviewed

  
• Radiofrequency Catheter Ablation for Atrial Fibrillation Followed by Cardiac Resynchronization Therapy in a Case of Lamin-Related Cardiomyopathy: A Case Report

  Mitsuhiko Yahata; Satoshi Sizuta; Mamoru Hayano; Naoki Onishi; Yasuhiro Sasaki; Kentaro Nakai; Koji Goto; Takeshi Makiyama; Takahiro Doi; Takeshi Kimura

  journal of arrhythmia, 2011, Peer-reviewed

  
• Long QT Syndromes Are Heterogeneous Disease Entities Presenting not only QT Prolongation but Multiple Phenotypes - Cases with Compound Heterozygous Mutations

  Minoru Horie; Hideki Itoh; Seiko Ohno; Takeru Makiyama; Wataru Shimizu; Shiro Kamakura; Kenshi Hayashi; Masakazu Yamagishi

  journal of arrhythmia, 2011, Peer-reviewed

  
• Mutations of the Cardiac Ryanodine Recepter (RyR2) Gene in Catecholaminergic Polymorphic Ventricular Tachycardia

  Mihoko Kawamura; Iori Nagaoka; Kenichi Dohchi; Yukiko Nishio; Hideki Itoh; Hiromi Kimura; Akashi Miyamoto; Yuka Mizusawa; Yuko Jito; Katsuya Ishida; Makoto Ito; Takeru Makiyama; Seiko Ohno; Naokata Sumitomo; Kotaro Oyama; Minoru Horie

  journal of arrhythmia, 2011, Peer-reviewed

  
• Carvedilol, a Non-Selective ß-with β-Blocker is Effective in Long QT Syndrome Type 2

  Hiromi Kimura; Yuka Mizusawa; Hideki Itoh; Akashi Miyamoto; Mihoko Kawamura; Tamiro Kawaguchi; Nobu Naiki; Yuko Oka; Seiko Ohno; Makoto Ito; Minoru Horie; Takeru Makiyama; Minoru Horie

  Journal of Arrhythmia, 2011, Peer-reviewed

  
• Carvedilol, a Non-Selective β-with α1-Blocker is Effective in Long QT Syndrome Type 2

  Hiromi Kimura; Yuka Mizusawa; Hideki Itoh; Akashi Miyamoto; Mihoko Kawamura; Tamiro Kawaguchi; Nobu Naiki; Yuko Oka; Seiko Ohno; Takeru Makiyama; Makoto Ito; Minoru Horie

  Journal of Arrhythmia, 2011, Peer-reviewed

  
• 僧帽弁閉鎖不全症に”out of proportion”な肺高血圧(PHOOP)を合併した一例

  塩井哲雄; 仁木俊一郎; 守上裕子; 牧山武; 木村剛; 村中弘之; 坂田隆造

  日本循環器学会近畿地方会(Web), 2011

  
• 心外膜起源の心室頻拍に対し心外膜アブレーションを施行したサルコイドーシスの1例

  太田千尋; 八幡光彦; 静田聡; 早野護; 樋上裕起; 大西尚昭; 佐々木康博; 守上裕子; 東谷暢也; 宝蔵麗子; 中井健太郎; 徳重明央; 田崎淳一; 今井逸雄; 齋藤成達; 土井孝浩; 小笹寧子; 牧山武; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2011

  
• 難治性高血圧に対して腎血管拡張術を施行した一例

  守上裕子; 多田朋弥; 牧山武; 塩井哲雄; 木村剛; 横井秀基

  日本循環器学会近畿地方会(Web), 2011

  
• WPW症候群へのablation施行後に心拡大の改善を認めた一例

  佐々木康博; 早野護; 大西尚昭; 八幡光彦; 牧山武; 土井孝浩; 静田聡; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2011

  
• 先天性QT延長症候群の遺伝的背景に基づく治療指針の検討 遺伝性不整脈疾患におけるTCAP遺伝子異常の解析

  牧山武

  先天性QT延長症候群の遺伝的背景に基づく治療指針の検討 平成22年度 総括・分担研究報告書, 2011

  
• 市中獲得型MRSA感染性心内膜炎にて急性心不全をきたしたが,外科治療にて救命し得た一例

  吉澤尚志; 木村剛; 塩井哲雄; 尾野亘; 静田聡; 牧山武; 小笹寧子; 土井孝浩; 西山慶; 今井逸雄; 守上裕子

  日本循環器学会近畿地方会(Web), 2011

  
• 進行性心臓伝導障害の病態診断と遺伝子基盤に関する研究 lamin A/C関連心筋症の疾患特異的ヒトiPS細胞作製・解析

  牧山武

  進行性心臓伝導障害の病態診断と遺伝子基盤に関する研究 平成22年度 総括・分担研究報告書, 2011

  
• A Novel Lamin A/C Gene Mutation in Siblings Treated with Cardiac Pacemaker

  Sano Kan; Watanabe Eiichi; Makiyama Takeru; Uchiyama Tatsushi; Sobue Yoshihiro; Okuda Kentarou; Yamamoto Mayumi; Horie Minoru; Ozaki Yukio

  Japanese Journal of Electrocardiology, 2011

  
• Mutations of the Cardiac Ryanodine Recepter (RyR2) Gene in Catecholaminergic Polymorphic Ventricular Tachycardia

  KAWAMURA Mihoko; NAGAOKA Iori; DOHCHI Kenichi; NISHIO Yukiko; ITOH Hideki; KIMURA Hiromi; MIYAMOTO Akashi; MIZUSAWA Yuka; JITO Yuko; ISHIDA Katsuya; ITO Makoto; MAKIYAMA Takeru; OHNO Seiko; SUMITOMO Naokata; OYAMA Kotaro; HORIE Minoru

  Japanese Journal of Electrocardiology, 22 Oct. 2010

  
• KCNE5遺伝子変異からBrugada症候群の性差を考える

  大野聖子; ZANKOV Dimitar P; DING Wei‐Guang; 伊藤英樹; 土井孝浩; 静田聡; 服部哲久; 牧山武; 松浦博; 堀江稔

  心電図, 10 Sep. 2010

  
• 非選択性α1‐βアドレナリン受容体遮断薬(カルベジロール)は2型QT延長症候群の心イベントを抑制する

  木村紘美; 伊藤英樹; 水澤有香; 宮本証; 岡優子; 川村美朋子; 西尾由貴子; 坂口知子; ZANKOV Dimitar; 丁維光; 牧山武; 伊藤誠; 松浦博; 堀江稔

  心電図, 10 Sep. 2010

  
• Long QT syndrome with compound mutations is associated with a severer phenotype: a Japanese multicenter study

  H. Itoh; W. Shimizu; K. Hayashi; K. Yamagata; T. Sakaguchi; T. Makiyama; Y. Miyamoto; M. Yamagishi; S. Kamakura; M. Horie

  EUROPEAN HEART JOURNAL, Sep. 2010

  
• 心電現象と性差 不整脈診療に性差の視点を活かす KCNE5遺伝子変異からBrugada症候群の性差を考える

  大野 聖子; Zankov Dimitar P; Ding Wei-Guang; 伊藤 英樹; 土井 孝浩; 静田 聡; 服部 哲久; 牧山 武; 松浦 博; 堀江 稔

  心電図, Sep. 2010

  
• 先天性QT延長症候群の遺伝子解析とその臨床的有用性―日本国内多施設登録からの検討―

  牧元久樹; 堀江稔; 小川聡; 相澤義房; 大江透; 草野研吾; 山岸正和; 蒔田直昌; 田中敏博; 牧山武; 吉永正夫; 萩原誠久; 鎌倉史郎; 宮本恵宏; 清水渉

  日本心臓病学会誌, 14 Aug. 2010

  
• 心血管疾患の遺伝子解析とその意義 先天性QT延長症候群の遺伝子解析とその臨床的有用性 日本国内多施設登録からの検討

  牧元 久樹; 堀江 稔; 小川 聡; 相澤 義房; 大江 透; 草野 研吾; 山岸 正和; 蒔田 直昌; 田中 敏博; 牧山 武; 吉永 正夫; 萩原 誠久; 鎌倉 史郎; 宮本 恵宏; 清水 渉

  日本心臓病学会誌, Aug. 2010

  
• 不整脈の遺伝子診断 1.先天性QT延長症候群の遺伝子診断―複数変異症例の検討―

  伊藤英樹; 清水渉; 林研至; 山形研一郎; 坂口知子; 大野聖子; 牧山武; 赤尾昌治; 藍智彦; 野田崇; 宮崎文; 宮本恵宏; 山岸正和; 鎌倉史郎; 堀江稔

  心電図, 28 Jul. 2010

  
• 家族性心臓伝導障害に同定されたconnexin 40遺伝子GJA5変異の機能異常

  蒔田直昌; 住友直方; 関明子; 渡部裕; 福原茂朋; 牧山武; 堀江稔; 萩原誠久; 望月直樹; SCHOTT Jean‐Jacques

  心電図, 28 Jul. 2010

  
• 不整脈の遺伝子診断 2.家族性ペースメーカー植込み症例における遺伝的背景の検討―心臓Na⁺チャネル病,Lamin A/C遺伝子関連心筋症―

  牧山武; 静田聡; 赤尾昌治; 木村剛; 堀江稔

  心電図, 28 Jul. 2010

  
• 不整脈の遺伝子診断 先天性QT延長症候群の遺伝子診断 複数変異症例の検討

  伊藤 英樹; 清水 渉; 林 研至; 山形 研一郎; 坂口 知子; 大野 聖子; 牧山 武; 赤尾 昌治; 藍 智彦; 野田 崇; 宮崎 文; 宮本 恵宏; 山岸 正和; 鎌倉 史郎; 堀江 稔

  心電図, Jul. 2010

  
• 不整脈の遺伝子診断 家族性ペースメーカー植込み症例における遺伝的背景の検討 心臓Na+チャネル病、Lamin A/C遺伝子関連心筋症

  牧山 武; 静田 聡; 赤尾 昌治; 木村 剛; 堀江 稔

  心電図, Jul. 2010

  
• QT延長症候群,Brugada症候群の小児の遺伝子変異と臨床像

  渡部誠一; 細川奨; 島田衣里子; 堀江稔; 牧山武

  日本小児循環器学会雑誌, 01 Jun. 2010

  
• 心房細動の起源として上大静脈のtriggered activityの関与が推測された1症例

  中尾哲史; 静田聡; 早野護; 土井孝浩; 八幡光彦; 西山慶; 牧山武; 赤尾昌治; 塩井哲雄; 尾野亘; 北徹, 木村剛

  J Arrhythmia, 25 Apr. 2010

  
• 家族性ペースメーカー植込み症例の遺伝的背景―心臓Naチャネル病,ラミンA/C関連心筋症―

  牧山武; 静田聡; 土井孝浩; 大野聖子; 服部哲久; 西尾由貴子; 木村剛; 赤尾昌治; 宮本証; 伊藤英樹; 堀江稔; 横出正之; 北徹

  Journal of Arrhythmia, 25 Apr. 2010

  
• SCN5A変異を認めた若年性洞不全症候群3症例の検討

  中島誠子; 花澤康司; 貝谷和昭; 吉谷和泰; 本岡眞琴; 泉知里; 中川義久; 牧山武; 堀江稔

  J Arrhythmia, 25 Apr. 2010

  
• QT短縮症候群で検出されたKCNJ2遺伝子変異の機能解析(内向き整流性K電流機能亢進の新たな機序)

  服部 哲久; 牧山 武; 赤尾 昌治; 江原 英治; 大野 聖子; 西尾 由貴子; 伊藤 英樹; 横出 正之; 木村 剛; 堀江 稔

  日本臨床分子医学会学術総会プログラム・抄録集, Apr. 2010

  
• ここまで進んだ不整脈の遺伝子診断 家族性ペースメーカー植込み症例の遺伝的背景 心臓Naチャネル病、ラミンA/C関連心筋症

  牧山 武; 静田 聡; 土井 孝浩; 大野 聖子; 服部 哲久; 西尾 由貴子; 木村 剛; 赤尾 昌治; 宮本 証; 伊藤 英樹; 堀江 稔; 横出 正之; 北 徹

  Journal of Arrhythmia, Apr. 2010

  
• 小児重症不整脈6例に対する静注アミオダロンの使用経験

  山村健一郎; 永田弾; 池田和幸; 原寿郎; 渡辺まみ江; 城尾邦隆; 堀江稔; 牧山武

  Prog Med, 23 Mar. 2010

  
• 若年発症のHCMに対してICD埋め込みを施行した例

  八幡光彦; 塩見紘樹; 仁木俊一郎; 東谷暢也; 中尾哲史; 早野護; 加藤義紘; 多田朋弥; 田崎淳一; 陣内俊和; 土井孝浩; 牧山武; 西山慶; 田村俊寛; 小笹寧子; 静田聡; 尾野亘; 塩井哲雄; 堀内久徳; 木村剛

  日本循環器学会近畿地方会(Web), 2010

  
• PCI後にPPISを来した症例

  守上裕子; 塩見紘樹; 東谷暢也; 田崎淳一; 徳重明央; 今井逸雄; 牧山武; 小笹寧子; 土井孝浩; 静田聡; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2010

  
• 発作性上室性頻拍症を来たし心不全を来した修正大血管転位症に対しアブレーション,CRT治療を行った例

  八幡光彦; 塩見紘樹; 仁木俊一郎; 東谷暢也; 早野護; 加藤義紘; 多田朋弥; 田崎淳一; 土井孝浩; 小笹寧子; 静田聡; 尾野亘; 塩井哲雄; 牧山武; 木村剛

  日本循環器学会近畿地方会(Web), 2010

  
• 進行性心臓伝導障害の病態診断と遺伝子基盤に関する研究 家族性ペースメーカー植込み症例の遺伝的背景に関する研究

  牧山武

  進行性心臓伝導障害の病態診断と遺伝子基盤に関する研究 平成21年度 総括・分担研究報告書, 2010

  
• ステロイドパルスが奏功したと考えられる心筋炎の一例

  仁木俊一郎; 塩見紘樹; 早野護; 牧山武; 土井孝浩; 小笹寧子; 田村俊寛; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2010

  
• 肝移植ドナー検診で見つかった家族性Brugada症候群の兄弟例

  渋谷倫太郎; 早野護; 八幡光彦; 牧山武; 土井孝浩; 静田聡; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2010

  
• AEDにて蘇生後,下側壁誘導に早期再分極を認めた特発性心室細動の一例

  石井充; 小川尚; 竹中淑夏; 西尾真季; 鵜木崇; 益永信豊; 船津順子; 金崎幹彦; 中島康代; 和田啓道; 長谷川浩二; 小坂田元太; 中野爲夫; 阿部充; 赤尾昌治; 土井孝浩; 牧山武; 静田聡; 木村剛

  日本循環器学会近畿地方会(Web), 2010

  
• 家族性突然死症候群の遺伝的背景の解明に関する研究 QT短縮症候群の病態解明に関する研究

  牧山武

  家族性突然死症候群の遺伝的背景の解明に関する研究 平成21年度 総括・分担研究報告書, 2010

  
• 不整脈の遺伝子診断 ２．家族性ペースメーカー植込み症例における遺伝的背景の検討―心臓Ｎａ｀＋´チャネル病，Ｌａｍｉｎ Ａ／Ｃ遺伝子関連心筋症―:―心臓Na+チャネル病，Lamin A/C遺伝子関連心筋症―

  牧山 武; 静田 聡; 赤尾 昌治; 木村 剛; 堀江 稔

  心電図, 2010

  
• 不整脈の遺伝子診断 １．先天性ＱＴ延長症候群の遺伝子診断―複数変異症例の検討―:―複数変異症例の検討―

  伊藤 英樹; 野田 崇; 宮崎 文; 宮本 恵宏; 山岸 正和; 鎌倉 史郎; 堀江 稔; 清水 渉; 林 研至; 山形 研一郎; 坂口 知子; 大野 聖子; 牧山 武; 赤尾 昌治; 藍 智彦

  心電図, 2010

  
• 家族性進行性心臓伝導障害に同定されたconnexin40遺伝子GJA5変異の機能異常

  蒔田直昌; 住友直方; 関明子; 萩原誠久; 渡部裕; 福原茂朋; 望月直樹; 牧山武; 堀江稔; SCHOTT Jean‐Jacques

  心電図, 05 Jun. 2009

  
• 家族性ペースメーカー植込み症例における遺伝的背景の検討―心臓Na⁺チャネル病,lamin A/C関連心筋症―

  牧山武; 横出正之; 赤尾昌治; 静田聡; 土井孝浩; 池田智之; 大野聖子; 服部哲久; 西尾由貴子; 木村剛; 北徹; 宮本証; 伊藤英樹; 堀江稔

  心電図, 05 Jun. 2009

  
• 先天性QT延長症候群の遺伝子診断―複数変異例の検討―

  伊藤英樹; 清水渉; 林研至; 山形研一郎; 坂口知子; 大野聖子; 牧山武; 赤尾昌治; 藍智彦; 野田崇; 宮崎彩; 宮本恵宏; 山岸正和; 鎌倉史郎; 堀江稔

  心電図, 05 Jun. 2009

  
• 慢性心房細動に対するカテーテル・アブレーションの有用性と安全性

  中尾哲史; 静田聡; 早野護; 根津知行; 山口孝之; 塚本学; 牧山武; 土井孝浩; 西山慶; 木村剛

  心電図, 05 Jun. 2009

  
• SCN5A遺伝子異常を伴った洞不全症候群合併Brugada症候群の1例

  早野護; 静田聡; 牧山武; 中尾哲史; 根津知行; 山口孝之; 塚本学; 土井孝浩; 西山慶; 赤尾昌治; 木村剛; 堀江稔

  心電図, 05 Jun. 2009

  
• 洞不全症候群を合併した心房細動に対するカテーテル・アブレーションの治療成績

  早野護; 静田聡; 中尾哲史; 根津知行; 山口孝之; 塚本学; 土井孝浩; 西山慶; 牧山武; 赤尾昌治; 木村剛

  心電図, 05 Jun. 2009

  
• 家族性ペースメーカー植込み症例における遺伝的背景の検討 心臓Na+チャネル病、lamin A/C関連心筋症

  牧山 武; 横出 正之; 赤尾 昌治; 静田 聡; 土井 孝浩; 池田 智之; 大野 聖子; 服部 哲久; 西尾 由貴子; 木村 剛; 北 徹; 宮本 証; 伊藤 英樹; 堀江 稔

  心電図, Jun. 2009

  
• 家族性ペースメーカ植込み例に認められた遺伝子異常

  内山達司; 渡邉英一; 佐野幹; 祖父江嘉洋; 奥田健太郎; 可児篤; 加藤千雄; 菱田仁; 尾崎行男; 牧山武; 堀江稔

  Ther Res, 20 May 2009

  
• SCN5Aのgain‐of‐functionによる家族性心房細動の発症メカニズムに関する数値解析的研究

  芦原貴司; 牧山武; 辻啓子; 八尾武憲; 中澤優子; 伊藤英樹; 城日加里; 赤尾昌治; 伊藤誠; 堀江稔

  心電図, 10 Mar. 2009

  
• カテーテルアブレーションにより著明に心機能改善を認めた拡張型心筋症合併慢性心房細動の一例

  早野護; 静田聡; 八幡光彦; 中尾哲史; 根津知行; 山口孝之; 塚本学; 土井孝浩; 西山慶; 牧山武; 塩井哲雄; 尾野亘; 木村剛

  日本循環器学会近畿地方会(Web), 2009

  
• 不整脈と遺伝子診断 Brugada症候群とその類縁疾患〔進行性伝導欠損(PCCD),家族性洞不全症候群,など〕の基礎,診断,治療

  牧山武; 赤尾昌治

  心臓, 15 Dec. 2008

  
• A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation

  MAKIYAMA Takeru; AKAO Masaharu; SHIZUTA Satoshi; DOI Takahiro; NISHIYAMA Kei; OKA Yuko; OHNO Seiko; NISHIO Yukiko; TSUJI Keiko; ITOH Hideki; KIMURA Takeshi; KITA Toru; HORIE Minoru

  心電図 = Electrocardiology, 03 Oct. 2008

  
• Brugada症候群,Brugada様心電図患者におけるSCN5A遺伝子解析

  牧山武; 赤尾昌治; 土井孝浩; 大野聖子; 西尾由貴子; 辻啓子; 伊藤英樹; 北徹, 堀江稔

  心電図, 03 Oct. 2008

  
• 濃厚な心突然死の家族歴を持つ徐脈性心房細動でlamin A/Cgene異常を認めEPSでVfが誘発されICDを植え込んだ1例

  若月大輔; 下島桐; 前澤秀之; 本田雄気; 河内恵介; 若林公平; 清水信行; 佐藤督忠; 浅野冬樹; 江波戸美緒; 東祐圭; 鈴木洋; 嶽山陽一; 牧山武; 堀江稔

  心電図, 03 Oct. 2008

  
• 徐脈に伴うトルサードポアンツに対するデバイス治療

  奥田健太郎; 牧山武; 岡優子; 坂口知子; 堀江稔; 渡邉英一; 佐野幹; 祖父江嘉洋; 内山達司; 可児篤; 加藤千雄; 菱田仁; 児玉逸雄; 尾崎行男

  心電図, 03 Oct. 2008

  
• SCN5Aのgrain‐of‐functionによる家族性心房細動の発症メカニズム:コンピュータシミュレーションによる検討

  芦原貴司; 牧山武; 辻啓子; 八尾武憲; 中澤優子; 伊藤英樹; 城日加里; 赤尾昌治; 伊藤誠; 堀江稔

  心電図, 03 Oct. 2008

  
• 核膜構成蛋白Lamin A/Cに変異を認める家族性ペースメーカ植込例

  内山達司; 牧山武; 堀江稔; 渡邉英一; 佐野幹; 祖父江嘉洋; 奥田健太郎; 可児篤; 加藤千雄; 菱田仁; 児玉逸雄; 尾崎行男

  心電図, 03 Oct. 2008

  
• SCN5Aのgain-of-functionによる家族性心房細動の発症メカニズム コンピュータシミュレーションによる検討

  芦原 貴司; 牧山 武; 辻 啓子; 八尾 武憲; 中澤 優子; 伊藤 英樹; 城 日加里; 赤尾 昌治; 伊藤 誠; 堀江 稔

  心電図, Oct. 2008

  
• 致死性不整脈をきたす疾患―診断と治療―12 QT延長症候群の遺伝子変異

  伊藤英樹; 宮本証; 牧山武; 大野聖子; 赤尾昌治; 堀江稔

  Heart View, 09 Sep. 2008

  
• Novel KCNE3 mutation reduced repolarizing potassium current and cause long QT syndrome

  S. Ohno; F. Toyoda; D. Zankov; T. Makiyama; W. Shimizu; Y. Miyamoto; S. Kamakura; H. Matsuura; T. Kita; M. Horie

  EUROPEAN HEART JOURNAL, Sep. 2008

  
• A KCNE1 polymorphism, D85N, is a disease-causing gene variant in congenital long QT syndrome

  M. Horie; S. Ohno; Y. Nishio; H. Itoh; K. Tsuji; T. Sakaguchi; T. Makiyama; M. Akao

  EUROPEAN HEART JOURNAL, Sep. 2008

  
• 【致死性不整脈をきたす疾患 診断と治療】 QT延長症候群の遺伝子変異

  伊藤 英樹; 宮本 証; 牧山 武; 大野 聖子; 赤尾 昌治; 堀江 稔

  Heart View, Sep. 2008

  
• 軽症のQT延長症候群に関連するKCNQ1遺伝子イントロン7上の新規スプライス変異の同定

  辻啓子; 赤尾昌治; 石井孝広; 芦原貴司; 牧山武; 大野聖子; 堀江稔

  日本RNA学会年会要旨集, 23 Jul. 2008

  
• RNAiを用いたCypDの抑制による新たな心筋保護治療 2光子励起共焦点レーザー顕微鏡でのリアルタイムイメージング

  加藤 雅史; 松本 円; 牧山 武; 井口 守丈; 武田 敏宏; 北 徹; 赤尾 昌治

  日本臨床分子医学会学術総会プログラム・抄録集, Jul. 2008

  
• SCN5Aの遺伝子異常(R179X)を有した下壁誘導ST上昇型Brugada症候群の1例

  川村美朋子; 小澤友哉; 八尾武憲; 芦原貴司; 伊藤英樹; 伊藤誠; 堀江稔; 杉本喜久; 八木崇文; 牧山武

  Journal of Arrhythmia, 25 Apr. 2008

  
• 薬剤誘発性QT延長症例の原因薬剤と遺伝子異常同定率

  伊藤英樹; 岡優子; 坂口知子; 長岡伊織; 中澤優子; 八尾武憲; 城日加里; 芦原貴司; 杉本喜久; 伊藤誠; 堀江稔; 大野聖子; 牧山武

  J Arrhythmia, 25 Apr. 2008

  
• 房室ブロックによる後天性QT延長症候群の遺伝学的背景とその臨床像

  岡優子; 伊藤英樹; 長岡伊織; 坂口知子; 芦原貴司; 伊藤誠; 堀江稔; 牧山武; 大野聖子

  J Arrhythmia, 25 Apr. 2008

  
• 早期の心臓再同期療法が有効であったLamin A/C遺伝子関連心筋症の1家系

  牧山武; 赤尾昌治; 静田聡; 土井孝浩; 大野聖子; 西尾由貴子; 西山慶; 木村剛; 北徹, 堀江稔

  Circ J, 20 Apr. 2008

  
• 69) 早期の心臓再同期療法が有効であったLamin A/C遺伝子関連心筋症の1家系(第104回日本循環器学会近畿地方会)

  牧山 武; 赤尾 昌治; 静田 聡; 土井 孝浩; 大野 聖子; 西尾 由貴子; 西山 慶; 木村 剛; 北 徹; 堀江 稔

  Circulation journal : official journal of the Japanese Circulation Society, 20 Apr. 2008

  
• イオンチャネル病のUp-to-date 薬剤誘発性QT延長症例の原因薬剤と遺伝子異常同定率

  伊藤 英樹; 岡 優子; 坂口 知子; 長岡 伊織; 中澤 優子; 八尾 武憲; 城 日加里; 芦原 貴司; 杉本 喜久; 伊藤 誠; 堀江 稔; 大野 聖子; 牧山 武

  Journal of Arrhythmia, Apr. 2008

  
• FRS-109 A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation(New Horizon in Diagnosis and Pathophysiology of Arrhythmia(A),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Shizuta Satoshi; Doi Takahiro; Nishiyama Kei; Oka Yuko; Oono Seiko; Nishio Yukiko; Tsuji Keiko; Itoh Hideki; Kimura Takeshi; Kita Toru; Horie Minoru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• OE-276 Familial Dilated Cardiomyopathy with Conduction Disease Caused by Lamin A/C Mutations : Efficacy of the Cardiac Resynchronization Therapy with a Defibrillator(Cardiomyopathy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

  Makiyama Takeru; Akao Masaharu; Shizuta Satoshi; Doi Takahiro; Oono Seiko; Nishio Yukiko; Nishiyama Kei; Kimura Takesi; Horie Minoru; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

  
• 変革する心房細動診療とその実践up‐to‐date《トピックス》心房細動と遺伝子異常

  牧山武; 赤尾昌治; 堀江稔

  内科, 01 Mar. 2008

  
• 心房細動と遺伝子異常 (特集 変革する心房細動診療とその実践up-to-date)

  牧山 武; 赤尾 昌治; 堀江 稔

  内科, Mar. 2008

  
• HEART's Selection Brugada症候群とその類縁疾患〔進行性伝導欠損(PCCD),家族性洞不全症候群,など〕の基礎,診断,治療

  牧山 武; 赤尾 昌治

  心臓, 2008

  
• Severe arrythmic events triggered by fever in a case of Brugada syndrome

  Koji Hanazawa; Toshihiro Tamura; Takahiro Doi; Satoshi Shizuta; Takeru Makiyama; Yutaka Furukawa; Yoshihisa Nakagawa; Toru Kita; Masaharu Akao; Takeshi Kimura

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 10 Nov. 2007, Peer-reviewed

  
• 家族性洞不全症候群の1家系に認めた心臓Naチャネル(SCN5A)遺伝子異常の電気生理学的機能解析

  牧山武; 赤尾昌治; 土井孝浩; 大野聖子; 西尾由貴子; 岡優子; 伊藤英樹; 北徹, 堀江稔

  心電図, 05 Sep. 2007

  
• 心筋Naチャネルの遺伝子異常と薬剤誘発性不整脈

  蒔田直昌; 清水渉; 宮本康二; 鎌倉史郎; 牧山武; 伊藤英樹; 堀江稔; 筒井裕之

  心電図, 05 Sep. 2007

  
• 薬物誘発性QT延長と不整脈 心筋Naチャネルの遺伝子異常と薬剤誘発性不整脈

  蒔田 直昌; 清水 渉; 宮本 康二; 鎌倉 史郎; 牧山 武; 伊藤 英樹; 堀江 稔; 筒井 裕之

  心電図, Sep. 2007

  
• KCNQ1遺伝子上の高頻度スプライス変異によるQT延長症候群発症のメカニズム

  辻啓子; 赤尾昌治; 石井孝広; 大野聖子; 牧山武; 竹中琴重; 土井孝浩; 春名良純; 吉田秀忠; 中島敏博; 北徹, 堀江稔

  日本RNA学会年会要旨集, 28 Jul. 2007

  
• チャネル病の修飾因子:総論

  伊藤英樹; 牧山武; 辻啓子; 坂口知子; 長岡伊織; 岡優子; 芦原貴司; 伊藤誠; 大野聖子; 赤尾昌治; 堀江稔

  心臓, 15 Jun. 2007

  
• チャネル病の修飾因子 チャネル病の修飾因子 総論

  伊藤 英樹; 牧山 武; 辻 啓子; 坂口 知子; 長岡 伊織; 岡 優子; 芦原 貴司; 伊藤 誠; 大野 聖子; 赤尾 昌治; 堀江 稔

  心臓, Jun. 2007

  
• KCNH2遺伝子変異(S641F)を認めたQT延長症候群の臨床および電気生理学的特徴

  坂口知子; 伊藤英樹; 長岡伊織; 伊藤誠; 堀江稔; 大野聖子; 牧山武; 吉田秀忠; 赤尾昌治; 尾畑憲司; 内田友二; 土谷健

  Therapeutic Research, 20 Mar. 2007

  
• 本邦におけるQT延長症候群の遺伝的背景~先天性と後天性における相違

  伊藤英樹; 辻啓子; 岡優子; 坂口知子; 長岡伊織; 大野聖子; 牧山武; 赤尾昌治; 伊藤誠; 堀江稔

  日本内科学会雑誌, 20 Feb. 2007

  
• Brugada症候群―解明された病態に基づいた診断と治療―Brugada症候群と遺伝子病―Brugada症候群とQT延長症候群など他の遺伝子病との関連について―

  牧山武; 赤尾昌治; 伊藤英樹; 堀江稔

  Heart View, 09 Feb. 2007

  
• 【Brugada症候群 解明された病態に基づいた診断と治療】 識る Brugada症候群と遺伝子病 Brugada症候群とQT延長症候群など他の遺伝子病との関連について

  牧山 武; 赤尾 昌治; 伊藤 英樹; 堀江 稔

  Heart View, Feb. 2007

  
• 致死性遺伝性不整脈疾患の遺伝子診断と臨床応用に関する研究 Brugada症候群の病態解明

  赤尾昌治; 大野聖子; 牧山武; 土井孝浩; 辻啓子

  致死性遺伝性不整脈疾患の遺伝子診断と臨床応用に関する研究 平成18年度 総括・分担研究報告書, 2007

  
• Modifiers for ion channel disease

  Itoh Hideki; Akao Masaharu; Hone Minoru; Makiyama Takeru; Tsuji Keiko; Sakaguchi Tomoko; Nagaoka Iori; Oka Yuko; Ashihara Takashi; Itoh Makoto; Ohno Seiko

  Shinzo, 2007

  
• Na channel gene mutations are prevalent in Japanese patients with various inherited arrhythmias

  T. Makiyama; M. Akao; K. Tsuji; T. Doi; S. Ohno; H. Yoshida; T. Kita; M. Horie

  EUROPEAN HEART JOURNAL, Aug. 2006

  
• KCNH2遺伝子変異(S641F)を認めたQT延長症候群の臨床および電気生理学的特徴

  坂口知子; 伊藤英樹; 山本聖; 長岡伊織; 岡優子; 八尾武憲; 小澤友哉; 中澤優子; 芦原貴司; 杉本喜久; 伊藤誠; 堀江稔; 大野聖子; 牧山武; 赤尾昌治; 吉田秀忠; 土谷健

  日本心電学会学術集会プログラム抄録集, 20 Jun. 2006

  
• KCNH2遺伝子変異(S641F)を認めたQT延長症候群の臨床および電気生理学的特徴

  坂口 知子; 伊藤 英樹; 山本 聖; 長岡 伊織; 岡 優子; 八尾 武憲; 小澤 友哉; 中澤 優子; 芦原 貴司; 杉本 喜久; 伊藤 誠; 堀江 稔; 大野 聖子; 牧山 武; 赤尾 昌治; 吉田 秀忠; 土谷 健

  Journal of Arrhythmia, May 2006

  
• Genetic analysis of hyperpolarization-activated and cyclic nucleoticle-gated cation channels 4 (HCN4) in patients with bradyarrhythmia

  T Doi; H Yoshida; S Ohno; T Makiyama; K Tsuji; Y Nishio; K Nishiyama; S Shizuta; M Akao; T Kimura; T Kita; M Horie

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Feb. 2006

  
• Positive arginine residue (R259) in S4-S5 linker affects activation properties of KCNQ1 potassium channel

  S. Ohno; H. Yoshida; K. Tsuji; T. Makiyama; K. Takenaka; H. Akao; T. Kita; M. Horie

  EUROPEAN HEART JOURNAL, Sep. 2005

  
• 電気生理学的解析でgain of functionとloss of functionが両方認められoverlap syndromeと考えられたLQT3の1例

  鶴見文俊; 伴由布子; 芳本潤; 原茂登; 満下紀恵; 金成海; 田中靖彦; 小野安生; 牧山武; 堀江稔

  日本小児循環器学会雑誌, 01 Sep. 2005

  
• 後天性QT延長症候群とアンダーセン症候群

  吉田秀忠; 竹中琴重; 牧山武; 大野聖子; 辻啓子; 土井孝浩; 堀江稔

  不整脈, 25 Apr. 2005

  
• 分子生物学的手法を用いた研究および遺伝子診断の臨床応用 後天性QT延長症候群とアンダーセン症候群

  吉田 秀忠; 竹中 琴重; 牧山 武; 大野 聖子; 辻 啓子; 土井 孝浩; 堀江 稔

  不整脈, Apr. 2005

  
• Genetic Analysis of PRKAG2 in a Family with Inherited Wolff-Parkinson-White Syndrome (Arrhythmia, Diagnosis/Pathophysiology/EPS 8 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Doi Takahiro; Akao Masaharu; Makiyama Takeru; Yoshida Hidetada; Takenaka Kotoe; Oono Seiko; Shizuta Satoshi; Nishiyama Kei; Nishio Yukiko; Tsuji Keiko; Kimura Tsuyoshi; Kita Toru

  Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

  
• High-risk for bradyarrhythmic complications in patients with Brugada syndrome caused by SCN5A gene mutations

  T Makiyama; M Akao; K Tsuji; T Doi; S Ono; K Takenaka; A Kobori; T Ninomiya; M Takano; N Makita; Y Higashi; T Kita; M Horie

  CIRCULATION, Oct. 2004

  
• Quantitative analysis of aberrant splicing caused by a splice-site mutation in KCNQ1 gene of a patient with long-QT syndrome

  K Tsuji; M Akao; T Ishii; T Makiyama; K Takenaka; S Ohno; T Doi; Y Kiyohara; M Horie

  CIRCULATION, Oct. 2004

  
• 洞不全症候群(SS)とBrugada症候群(BS)を合併したSCN5Aの変異の1例

  柳沢史子; 東祐圭; 下島桐; 全田直子; 堤健; 岳山陽一; 牧山武; 堀江稔

  日本心電学会学術集会プログラム抄録集, 19 Aug. 2004

  
• ハイリスク症例を含むWPW症候群が強く出現した一家系

  土井孝浩; 静田聡; 赤尾昌治; 牧山武; 木村剛, 北徹

  日本心電学会学術集会プログラム抄録集, 19 Aug. 2004

  
• 不整脈源性右室心筋症(ARVC/D)に対するICD治療成績

  小堀 敦志; 牧山 武; 竹中 琴重; 全 栄和; 綿貫 正人; 池口 滋; 堀江 稔

  不整脈, Apr. 2004

  
• ΔQPK1707-1709によるLQT3の臨床的特徴

  本田 俊弘; 古山 准二郎; 林 雅道; 本田 喬; 牧山 武; 堀江 稔

  不整脈, Apr. 2004

  
• 長期透析が経皮的冠動脈インターベンション後の再狭窄に及ぼす影響

  中島康弘; 片岡一明; 谷口良司; 宮本忠司; 星野康三; 牧山武; 加藤貴雄; 堀江貴裕; 長央和也

  Jpn J Interv Cardiol, 10 Feb. 2004

  
• NIRステント留置後の再狭窄予測因子に関する検討―ステント長は再狭窄率に影響しない

  宮本忠司; 永井康三; 佐藤幸人; 牧山武; 長央和也; 中島康弘; 加藤貴雄; 堀江貴裕; 谷口良司

  Jpn J Interv Cardiol, 10 Feb. 2004

  
• 一般診療でのQT延長の診断と治療方針

  竹中琴重; 小堀敦志; 二宮智紀; 牧山武; 大野聖子; 堀江稔

  臨床医, 10 Jan. 2004

  
• Brugada症候群におけるSCN5AのSNP(一塩基多型)解析

  牧山武; 大野聖子; 竹中琴重; 小堀敦志; 二宮智紀; 蒔田直昌; 堀江稔

  日本心電学会学術集会プログラム抄録集, 18 Aug. 2003

  
• Carvedilol enhances insulin release from clonal .BETA.-cells through blockade of KATP channels.

  二宮智紀; 小堀敦志; 竹中琴重; 大野聖子; 牧山武; 堀江稔

  日本心電学会学術集会プログラム抄録集, 18 Aug. 2003

  
• Radiusステント留置時の後拡張に関する検討

  片岡 一明; 永井 康三; 李 俊峡; 長央 和也; 加藤 貴雄; 堀江 貴裕; 中島 康弘; 牧山 武; 宮本 忠司; 鷹津 良樹

  Journal of Cardiology, Aug. 2003

  
• カルベジロールはKATPチャネルの遮断を経たクローンβ細胞からのインスリンの放出を増強する(Carvedilol enhances insulin release from clonal β-cells through blockade of K ATP channels)

  二宮 智紀; 小堀 敦志; 竹中 琴重; 大野 聖子; 牧山 武; 堀江 稔

  心電図, Aug. 2003

  
• A mutation of SCN5A manifests both LQTS and Brugada syndrome; The overlap syndrome

  S Ono; T Makiyama; M Matsumoto; K Takenaka; A Kobori; T Ninomiya; W Shimizu; T Kita; M Horie

  CIRCULATION, May 2003

  
• 遺伝性不整脈 遺伝子から臨床まで(Hereditary Arrhythmia: From Gene to Clinics)

  堀江 稔; 藍 智彦; 吉田 秀忠; 久保田 友之; 二宮 智紀; 小堀 敦志; 竹中 琴重; 大野 聖子; 牧山 武; 辻 敬子; 山下 文男; 鷲塚 隆; 相澤 義房; 蒔田 直昌; 清水 渉; 鎌倉 史郎; 藤原 裕一郎; 久保 義弘

  不整脈, Apr. 2003

  
• ステント長と血管径が再狭窄にあたえる影響 冠動脈用ロングステントにおける検討

  永井 康三; 佐藤 幸人; 宮本 忠司; 山田 亮; 谷口 良司; 牧山 武; 中島 康弘; 李 俊侠; 松森 昭; 鷹津 良樹

  Journal of Cardiology, Aug. 2002

  
• 重症心不全患者における外来でのolprinone短時間点滴投与

  佐藤 幸人; 鷹津 良樹; 山田 亮; 谷口 良司; 永井 康三; 牧山 武; 松森 昭

  Journal of Cardiology, Aug. 2002

  
• 経皮的血管縫合器(Prostar XL/Closer)によるPCI後の縫合止血の成績とその検討

  中島康弘; 永井康三; 牧山武; 加藤貴雄; 堀江貴裕; 李俊峡; 宮本忠司; 鷹津良樹

  Jpn J Interv Cardiol, 10 Jun. 2002

  
• Radiusステントの初期および慢性期成績の検討

  永井康三; 宮本忠司; 李俊峡; 牧山武; 中島康弘; 堀江貴裕; 加藤貴雄; 鷹津良樹

  Jpn J Interv Cardiol, 10 Jun. 2002

  
• 血中心筋トロポニンT測定にて早期診断と治療効果を確認し得た好酸球増多症候群の心臓病変の1例

  谷口良司; 佐藤幸人; 永井康三; 牧山武; 岡田英志; 中島康弘; 松森昭; 鷹津良樹

  心臓, 15 Mar. 2002

  
• 慢性腎不全患者の心疾患 慢性腎不全透析患者における冠動脈造影所見および治療成績の検討

  中島康弘; 宮本忠司; 谷口良司; 永井康三; 牧山武; 加藤貴雄; 堀江貴裕; 佐藤幸人; 鷹津良樹

  診療と新薬, 28 Feb. 2002

  
• 肥大型心筋症における微少心筋障害の検出 心筋トロポニンTを用いて

  永井 康三; 佐藤 幸人; 宮本 忠司; 谷口 良司; 牧山 武; 岡田 英志; 中島 康弘; 鷹津 良樹

  診療と新薬, Feb. 2002

  
• 慢性腎不全透析患者における冠動脈造影所見及び治療成績の検討

  中島 康弘; 宮本 忠司; 谷口 良司; 永井 康三; 牧山 武; 加藤 貴雄; 堀江 貴裕; 佐藤 幸人; 鷹津 良樹

  診療と新薬, Feb. 2002

  
• Measurement of serum concentrations of cardiac troponin. T in the management and treatment of cardiac disorders in patients with hypereosinophilic syndrome-A case report

  Taniguchi Ryoji; Sato Yukihito; Nagai Kozo; Makiyama Takeru; Okada Hideshi; Nakashima Yasuhiro; Matsumori Akira; Takatsu Yoshiki

  Shinzo, 2002

  
• 血中心筋トロポニンTの心アミロイドーシスにおける測定意義

  牧山武; 佐藤幸人; 宮本忠司; 谷口良司; 永井康三; 岡田英志; 中島康弘; 鷹津良樹

  血管と心研究会誌, Dec. 2001

  
• 肥大型心筋症 肥大型心筋症における微少心筋障害の検出 心筋トロポニンTを用いて

  永井康二; 佐藤幸人; 宮本忠司; 谷口良司; 牧山武; 岡田英志; 中島康弘; 鷹津良樹

  診療と新薬, 28 Sep. 2001

  
• 肥大型心筋症における微少心筋障害の検出 心筋トロポニンTを用いて

  永井 康三; 佐藤 幸人; 宮本 忠司; 谷口 良司; 牧山 武; 岡田 英志; 中島 康弘; 鷹津 良樹

  診療と新薬, Sep. 2001

  
• Nir stentの初期および慢性期成績ならびにMultilink stentとの比較

  永井康三; 佐藤幸人; 谷口良司; 牧山武; 岡田英志; 中島康弘; 鷹津良樹

  Jpn J Interv Cardiol, 10 Jun. 2001

  
• Stent in‐stentの初期および慢性期成績

  牧山武; 佐藤幸人; 谷口良司; 永井康三; 岡田英志; 中島康弘; 鷹津良樹

  Jpn J Interv Cardiol, 10 Jun. 2001

  
• 経皮的心膜生検が診断に有用であった一例 (兵庫県立尼崎病院S,兵庫県立東洋医学研究所S)

  牧山武; 佐藤幸人; 谷口良司; 永井康三; 岡田英志; 中島康弘; 鷹津良樹

  兵庫県立尼崎病院年報, 10 Mar. 2001

  
• ステントを留置した治療抵抗性異型狭心症の1例

  岡田 英志; 山田 亮; 佐藤 幸人; 谷口 良司; 永井 康三; 牧山 武; 鷹津 良樹

  兵庫県立尼崎病院年報, Mar. 2001

  
• 経皮的心膜生検が診断に有用であった1例

  牧山 武; 佐藤 幸人; 谷口 良司; 永井 康三; 岡田 英志; 中島 康弘; 鷹津 良樹

  兵庫県立尼崎病院年報, Mar. 2001

  
• 経皮的心膜生検が補助的診断として有用であった心嚢水貯留患者の自験例

  牧山 武; 佐藤 幸人; 谷口 良司; 永井 康三; 岡田 英志; 中島 康弘; 篠山 重威; 松森 昭; 鷹津 良樹

  呼吸と循環, Mar. 2001

  
• Percutaneous Pericardial Biopsy for the Diagnosis of Pericardia Effusion : Case reports

  牧山 武; 佐藤 幸人; 谷口 良司

  呼吸と循環, Mar. 2001

  
• MultiLinkステントの初期および慢性期成績

  佐藤幸人; 山田亮; 谷口良司; 永井康三; 牧山武; 岡田英志; 鷹津良樹

  Jpn J Interv Cardiol, 10 Feb. 2001

  
• MultiLinkステントの初期及び慢性期成績

  佐藤 幸人; 山田 亮; 谷口 良司; 永井 康三; 牧山 武; 岡田 英志; 鷹津 良樹

  Japanese Journal of Interventional Cardiology, Feb. 2001

  
• ステント留置により発作が著明に減少した薬剤抵抗性異型狭心症の1例

  山田亮; 佐藤幸人; 岡田英志; 牧山武; 永井康三; 谷口良司; 鷹津良樹

  血管と心研究会誌, Dec. 2000

  
• 心嚢水貯留患者に対する経皮的心膜生検の診断的有用性について

  牧山武; 佐藤幸人; 岡田英志; 永井康三; 谷口良司; 鷹津良樹

  Jpn Circ J, 20 Oct. 2000

  
• 103) 心嚢水貯留患者に対する経皮的心膜生検の診断的有用性について

  牧山 武; 佐藤 幸人; 岡田 英志; 永井 康三; 谷口 良司; 鷹津 良樹

  Japanese circulation journal, 20 Oct. 2000

  
• 手術に踏み切れなかったhigh flow肺高血圧を伴う心室中隔欠損症の一例

  牧山武; 佐藤幸人; 山田亮; 谷口良司; 永井康三; 岡田英志; 鷹津良樹

  診療と新薬, 28 Sep. 2000

  
• 【先天性心疾患 ADULT】 手術に踏み切れなかったhigh flow肺高血圧を伴う心室中隔欠損症の一例

  牧山 武; 佐藤 幸人; 山田 亮; 谷口 良司; 永井 康三; 岡田 英志; 鷹津 良樹

  診療と新薬, Sep. 2000

  
• 当院における透析患者の冠動脈造影所見及び治療成績の検討

  谷口良司; 佐藤幸人; 岡田英志; 永井康三; 牧山武; 山田亮; 鷹津良樹

  Jpn Circ J, 20 Apr. 2000

  
• 血中心筋トロポニンTの心アミロイドーシスにおける測定意義

  牧山武; 佐藤幸人; 岡田英志; 永井康三; 谷口良司; 山田亮; 鷹津良樹

  Jpn Circ J, 20 Apr. 2000

  
• 10) 当院における透析患者の冠動脈造影所見及び治療成績の検討

  谷口 良司; 佐藤 幸人; 岡川 英志; 永井 康三; 牧山 武; 山田 亮; 鷹津 良樹

  Japanese circulation journal, 20 Apr. 2000

  
• 119) 血中心筋トロポニンTの心アミロイドーシスにおける測定意義

  牧山 武; 佐藤 幸人; 岡田 英志; 永井 康三; 谷口 良司; 山田 亮; 鷹津 良樹

  Japanese circulation journal, 20 Apr. 2000

  
• 【二次性心筋症と心筋炎】 C型肝炎ウイルスが原因として疑われた拡張型心筋症における血中心筋トロポニンTの経時的測定とインターフェロン治療効果判定への応用

  佐藤 幸人; 山田 亮; 谷口 良司; 牧山 武; 永井 康三; 岡田 英志; 片岡 一明; 鷹津 良樹; 松森 昭; 篠山 重威

  診療と新薬, Mar. 2000

  
• C型肝炎ウイルスが原因として疑われた拡張型心筋症における血中心筋トロポニンTの経時的測定とインターフェロン治療効果判定への応用

  佐藤幸人; 山田亮; 谷口良司; 永井康三; 牧山武; 鷹津良樹; 松森昭; 片岡一明; 篠山重威

  Japanese Circulation Journal, 01 Mar. 2000

  
• P413 C型肝炎ウイルスが原因として疑われた拡張型心筋症における血中心筋トロポニンTの経時的測定とインターフェロン治療効果判定への応用

  佐藤 幸人; 山田 亮; 谷口 良司; 永井 康三; 牧山 武; 岡田 英志; 鷹津 良樹; 松森 昭; 片岡 一明; 篠山 重威

  Japanese circulation journal, 01 Mar. 2000

  
• C型肝炎ウイルスによると考えられた拡張型心筋症における血中心筋トロポニンTの経時的測定とインターフェロン治療効果判定への応用

  佐藤幸人; 山田亮; 谷口良司; 永井康三; 牧山武; 岡田英志; 鷹津良樹; 松森昭; 篠山重威

  日本内科学会雑誌, 20 Feb. 2000

  
• Measurement of Serum Concentrations of Cardiac Troponin T in Patients with Hypereosinophilic Syndrome: A Sensitive Non-invasive Marker of Cardiac Disorder

  Yukihito Sato; Ryoji Taniguchi; Tasuku Yamada; Kozo Nagai; Takeru Makiyama; Hideshi Okada; Yoshiki Takatsu; Akira Matsumori; Shigetake Sasayama

  Internal Medicine, 2000, Peer-reviewed

  
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