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篠原 美都

シノハラ ミト

医学研究科 医学専攻遺伝医学講座分子遺伝学 助教

篠原 美都
list
    Last Updated :2022/07/01

    基本情報

    学部兼担

    • 医学部

    学位

    • 博士(医学)(京都大学)

    出身学校・専攻等

    • 京都大学, 医学部医学科, 卒業

    ID,URL

    researchmap URL

    list
      Last Updated :2022/07/01

      研究

      研究テーマ・研究概要

      • 研究テーマ

        精子形成に関わる幹細胞の増殖と分化のメカニズムの解明、精子幹細胞を用いた遺伝子改変個体作成法の開発

      研究分野

      • ライフサイエンス, 遺伝学

      論文

      • Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoids.
        Mito Kanatsu-Shinohara; Narumi Ogonuki; Shogo Matoba; Hiroko Morimoto; Yusuke Shiromoto; Atsuo Ogura; Takashi Shinohara
        Stem cell reports, 2022年04月12日
      • Genomic stability of mouse spermatogonial stem cells in vitro
        Shinichiro Chuma; Mito Kanatsu-Shinohara; Ami Katanaya; Mihoko Hosokawa; Takashi Shinohara
        Scientific Reports, 2021年12月
      • Cdc42 is required for male germline niche development in mice.
        Yoshifumi Mori; Seiji Takashima; Mito Kanatsu-Shinohara; Zheng Yi; Takashi Shinohara
        Cell reports, 2021年08月17日
      • Spermatogonial stem cell transplantation into nonablated mouse recipient testes.
        Hiroko Morimoto; Narumi Ogonuki; Mito Kanatsu-Shinohara; Shogo Matoba; Atsuo Ogura; Takashi Shinohara
        Stem cell reports, 2021年07月13日
      • OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†.
        Yoshifumi Mori; Narumi Ogonuki; Ayumi Hasegawa; Mito Kanatsu-Shinohara; Atsuo Ogura; Yufeng Wang; John R McCarrey; Takashi Shinohara
        Biology of reproduction, 2021年03月11日
      • An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia.
        Hiroko Morimoto; Takuya Yamamoto; Takehiro Miyazaki; Narumi Ogonuki; Atsuo Ogura; Takashi Tanaka; Mito Kanatsu-Shinohara; Chihiro Yabe-Nishimura; Hongliang Zhang; Yves Pommier; Andreas Trumpp; Takashi Shinohara
        Genes & development, 2021年02月01日
      • CD2 is a surface marker for mouse and rat spermatogonial stem cells.
        Mito Kanatsu-Shinohara; Guiying Chen; Hiroko Morimoto; Takashi Shinohara
        The Journal of reproduction and development, 2020年08月20日, 査読有り
      • Autologous transplantation of spermatogonial stem cells restores fertility in congenitally infertile mice.
        Mito Kanatsu-Shinohara; Narumi Ogonuki; Shogo Matoba; Atsuo Ogura; Takashi Shinohara
        Proceedings of the National Academy of Sciences of the United States of America, 2020年04月07日, 査読有り
      • Transgenesis and Genome Editing of Mouse Spermatogonial Stem Cells by Lentivirus Pseudotyped with Sendai Virus F Protein.
        Takashi Shinohara; Mito Kanatsu-Shinohara
        Stem cell reports, 2020年03月10日, 査読有り
      • Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.
        Mito Kanatsu-Shinohara; Takuya Yamamoto; Hidehiro Toh; Yasuhiro Kazuki; Kanako Kazuki; Junichi Imoto; Kazuho Ikeo; Motohiko Oshima; Katsuhiko Shirahige; Atsushi Iwama; Yoichi Nabeshima; Hiroyuki Sasaki; Takashi Shinohara
        Proceedings of the National Academy of Sciences of the United States of America, 2019年08月13日, 査読有り
      • Expression and functional analyses of EPHA2 in mouse spermatogonial stem cells.
        Morimoto H; Kanatsu-Shinohara M; Orwig K.E; Shinohara T
        Biol. Reprod., 2019年08月, 査読有り
      • ROS amplification drives mouse spermatogonial stem cell self-renewal.
        Morimoto H; Kanastu-Shinohara M; Ogonuki N; Kamimura S; Ogura A; Yabe-Nishimura C; Mori Y; Morimoto T; Watanabe S; Otsu K; Yamamoto T; Shinohara T
        Life science alliance, 2019年04月, 査読有り
      • Sendai virus-mediated transduction of mammalian spermatogonial stem cells.
        Watanabe S; Kanatsu-Shinohara, M; Shinohara T
        Biol. Reprod., 2019年02月, 査読有り
      • Reversible inhibition of the blood-testis barrier protein improves stem cell homing in mouse testes.
        Kanatsu-Shinohara, M; Morimoto H; Watanabe S; Shinohara T
        J. Reprod. Dev., 2018年12月, 査読有り
      • In Vivo Genetic Manipulation of Spermatogonial Stem Cells and Their Microenvironment by Adeno-Associated Viruses.
        Satoshi Watanabe; Mito Kanatsu-Shinohara; Narumi Ogonuki; Shogo Matoba; Atsuo Ogura; Takashi Shinohara
        Stem cell reports, 2018年05月08日, 査読有り
      • Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice
        Takashi Shinohara; Kanako Kazuki; Narumi Ogonuki; Hiroko Morimoto; Shogo Matoba; Kei Hiramatsu; Kazuhisa Honma; Teruhiko Suzuki; Takahiko Hara; Atsuo Ogura; Mitsuo Oshimura; Mito Kanatsu-Shinohara; Yasuhiro Kazuki
        STEM CELL REPORTS, 2017年10月, 査読有り
      • Nonrandom contribution of left and right testes to germline transmission from mouse spermatogonial stem cells.
        Kanatsu-Shinohara, M; Naoki, N; Shinohara, T
        Biol. Reprod., 2017年, 査読有り
      • Adeno-associated virus-mediated delivery of genes to mouse spermatogonial stem cells
        Satoshi Watanabe; Mito Kanatsu-Shinohara; Narumi Ogonuki; Shogo Matoba; Atsuo Ogura; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2017年01月, 査読有り
      • Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal
        Mito Kanatsu-Shinohara; Takashi Tanaka; Narumi Ogonuki; Atsuo Ogura; Hiroko Morimoto; Pei Feng Cheng; Robert N. Eisenman; Andreas Trumpp; Takashi Shinohara
        GENES & DEVELOPMENT, 2016年12月, 査読有り
      • Nonrandom Germline Transmission of Mouse spermatogonial Stem Cells
        Mito Kanatsu-Shinohara; Honda Naoki; Takashi Shinohara
        DEVELOPMENTAL CELL, 2016年08月, 査読有り
      • The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells
        Takashi Tanaka; Mito Kanatsu-Shinohara; Zhenmin Lei; C. V. Rao; Takashi Shinohara
        STEM CELL REPORTS, 2016年08月, 査読有り
      • Fertility of Male Germline Stem Cells Following Spermatogonial Transplantation in Infertile Mouse Models
        Mito Kanatsu-Shinohara; Hiroko Morimoto; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2016年05月, 査読有り
      • Enrichment of Mouse Spermatogonial Stem Cells by the Stem Cell Dye CDy1
        Mito Kanatsu-Shinohara; Hiroko Morimoto; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2016年01月, 査読有り
      • Pluripotent cell derivation from male germline cells by suppression of Dmrt1 and Trp53
        Takashi Tanaka; Mito Kanatsu-Shinohara; Michiko Hirose; Atsuo Ogura; Takashi Shinohara
        Journal of Reproduction and Development, 2015年10月21日, 査読有り
      • The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage
        Takashi Tanaka; Mito Kanatsu-Shinohara; Takashi Shinohara
        Journal of Reproduction and Development, 2015年08月25日, 査読有り
      • Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal
        Seiji Takashima; Mito Kanatsu-Shinohara; Takashi Tanaka; Hiroko Morimoto; Kimiko Inoue; Narumi Ogonuki; Mayumi Jijiwa; Masahide Takahashi; Atsuo Ogura; Takashi Shinohara
        Stem Cell Reports, 2015年03月10日, 査読有り
      • ROS-generating oxidese Nox3 regulates the self-renewal of mouse spermatogonial stem cells.
        Morimoto, H; Kanatsu-Shinohara, M; Shinohara, T
        Biol. Reprod., 2015年, 査読有り
      • The Trp53-Trp53inp1-Tnfrsf10b pathway regulates the radiation response of mouse spermatogonial stem cells
        Kei Ishii; Masamichi Ishiai; Hiroko Morimoto; Mito Kanatsu-Shinohara; Ohtsura Niwa; Minoru Takata; Takashi Shinohara
        Stem Cell Reports, 2014年10月14日, 査読有り
      • Improved serum- and feeder-free culture of mouse germline stem cells
        Mito Kanatsu-Shinohara; Narumi Ogonuki; Shogo Matoba; Hiroko Morimoto; Atsuo Ogura; Takashi Shinohara
        Biology of Reproduction, 2014年10月01日, 査読有り
      • Cell-cycle-dependent Colonization of Mouse Spermatogonial Stem Cells After Transplantation into Seminiferous Tubules
        Kei Ishii; Mito Kanatsu-Shinohara; Takashi Shinohara
        JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2014年02月, 査読有り
      • Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal
        Mito Kanatsu-Shinohara; Ichiro Onoyama; Keiichi I. Nakayama; Takashi Shinohara
        Proceedings of the National Academy of Sciences of the United States of America, 2014年, 査読有り
      • Spermatogonial stem cell self-renewal and development
        Mito Kanatsu-Shinohara; Takashi Shinohara
        Annual Review of Cell and Developmental Biology, 2013年10月, 査読有り
      • Regulation of pluripotency in male germline stem cells by Dmrt1
        Seiji Takashima; Michiko Hirose; Narumi Ogonuki; Miki Ebisuya; Kimiko Inoue; Mito Kanatsu-Shinohara; Takashi Tanaka; Eisuke Nishida; Atsuo Ogura; Takashi Shinohara
        Genes and Development, 2013年09月, 査読有り
      • ROS are required for mouse spermatogonial stem cell self-renewal
        Hiroko Morimoto; Kazumi Iwata; Narumi Ogonuki; Kimiko Inoue; Ogura Atsuo; Mito Kanatsu-Shinohara; Takeshi Morimoto; Chihiro Yabe-Nishimura; Takashi Shinohara
        Cell Stem Cell, 2013年06月06日, 査読有り
      • Enrichment of mouse spermatogonial stem cells based on aldehyde dehydrogenase activity.
        Kanatsu-Shinohara, M; Mori, Y; Shinohara, T
        Biol. Reprod., 2013年, 査読有り
      • Enrichment of Mouse Spermatogonial Stem Cells by Melanoma Cell Adhesion Molecule Expression
        Mito Kanatsu-Shinohara; Hiroko Morimoto; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2012年12月, 査読有り
      • Reconstitution of mouse spermatogonial stem cell niches in culture
        Mito Kanatsu-Shinohara; Kimiko Inoue; Seiji Takashima; Masanori Takehashi; Narumi Ogonuki; Hiroko Morimoto; Takashi Nagasawa; Atsuo Ogura; Takashi Shinohara
        Cell Stem Cell, 2012年10月05日, 査読有り
      • Hybridization of testis-derived stem cells with somatic cells and embryonic stem cells in mice
        Masanori Takehashi; Masako Tada; Mito Kanatsu-Shinohara; Hiroko Morimoto; Yasuhiro Kazuki; Mitsuo Oshimura; Takashi Tada; Takashi Shinohara
        Biology of Reproduction, 2012年06月01日, 査読有り
      • FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation
        Kei Ishii; Mito Kanatsu-Shinohara; Shinya Toyokuni; Takashi Shinohara
        Development, 2012年05月15日, 査読有り
      • In Vitro transformation of mouse testis cells by oncogene transfection
        Hiroko Morimoto; Jiyoung Lee; Takashi Tanaka; Kei Ishii; Shinya Toyokuni; Mito Kanatsu-Shinohara; Takashi Shinohara
        Biology of Reproduction, 2012年05月01日, 査読有り
      • Rac mediates mouse spermatogonial stem cell homing to germline niches by regulating transmigration through the blood-testis barrier
        Seiji Takashima; Mito Kanatsu-Shinohara; Takashi Tanaka; Masanori Takehashi; Hiroko Morimoto; Takashi Shinohara
        Cell Stem Cell, 2011年11月04日, 査読有り
      • Dynamic Changes in EPCAM Expression during Spermatogonial Stem Cell Differentiation in the Mouse Testis
        Mito Kanatsu-Shinohara; Seiji Takashima; Kei Ishii; Takashi Shinohara
        PLOS ONE, 2011年08月, 査読有り
      • Homologous Recombination in Rat Germline Stem Cells
        Mito Kanatsu-Shinohara; Megumi Kato-Itoh; Masahito Ikawa; Masanori Takehashi; Makoto Sanbo; Yuka Morioka; Takashi Tanaka; Hiroko Morimoto; Masumi Hirabayashi; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2011年07月, 査読有り
      • Unstable Side Population Phenotype of Mouse Spermatogonial Stem Cells In Vitro
        Takashi Shinohara; Kei Ishii; Mito Kanatsu-Shinohara
        JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2011年04月
      • Serum- and Feeder-Free Culture of Mouse Germline Stem Cells
        Mito Kanatsu-Shinohara; Kimiko Inoue; Narumi Ogonuki; Hiroko Morimoto; Atsuo Ogura; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2011年01月
      • Neonatal mouse testis-derived multipotent germline stem cells improve the cardiac function of acute ischemic heart mouse model
        Toru Iwasa; Shiro Baba; Hiraku Doi; Shinji Kaichi; Noritaka Yokoo; Takahiro Mima; Mito Kanatsu-Shinohara; Takashi Shinohara; Tatsutoshi Nakahata; Toshio Heike
        Biochemical and Biophysical Research Communications, 2010年09月, 査読有り
      • Generation of genetically modified animals using spermatogonial stem cells
        Masanori Takehashi; Mito Kanatsu-Shinohara; Takashi Shinohara
        DEVELOPMENT GROWTH & DIFFERENTIATION, 2010年04月
      • Genetic Influences in Mouse Spermatogonial Stem Cell Self-Renewal
        Mito Kanatsu-Shinohara; Narumi Ogonuki; Hiromi Miki; Kimiko Inoue; Hiroko Morimoto; Seiji Takashima; Atsuo Ogura; Takashi Shinohara
        JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2010年02月
      • Transmission distortion by loss of p21 or p27 cyclin-dependent kinase inhibitors following competitive spermatogonial transplantation. Proc. Natl. Acad. Sci. USA 107(14):6210-5 (2010)
        Kanatsu-Shinohara M; Takashima S; Shinohara T
        2010年
      • GERMLINE MODIFICATION USING MOUSE SPERMATOGONIAL STEM CELLS
        Mito Kanatsu-Shinohara; Takashi Shinohara
        METHODS IN ENZYMOLOGY, VOL 477: GUIDE TO TECHNIQUES IN MOUSE DEVELOPMENT, PART B: MOUSE MOLECULAR GENETICS, SECOND EDITION, 2010年
      • Bone marrow engraftment but limited expansion of hematopoietic cells from multipotent germline stem cells derived from neonatal mouse testis
        Momoko Yoshimoto; Toshio Heike; Hsi Chang; Mito Kanatsu-Shinohara; Shiro Baba; Joseph T. Varnau; Takashi Shinohara; Mervin C. Yoder; Tatsutoshi Nakahata
        EXPERIMENTAL HEMATOLOGY, 2009年12月, 査読有り
      • Phenotypic Plasticity of Mouse Spermatogonial Stem Cells
        Hiroko Morimoto; Mito Kanatsu-Shinohara; Seiji Takashima; Shinichiro Chuma; Norio Nakatsuji; Masanori Takehashi; Takashi Shinohara
        PLOS ONE, 2009年11月, 査読有り
      • Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects
        Seiji Takashima; Masanori Takehashi; Jiyoung Lee; Shinichiro Chuma; Masaki Okano; Kenichiro Hata; Isao Suetake; Norio Nakatsuji; Hiroyuki Miyoshi; Shoji Tajima; Yoriko Tanaka; Shinya Toyokuni; Hiroyuki Sasaki; Mito Kanatsu-Shinohara; Takashi Shinohara
        Biology of Reproduction, 2009年07月, 査読有り
      • Genetic Reconstruction of Mouse Spermatogonial Stem Cell Self-Renewal In Vitro by Ras-Cyclin D2 Activation
        Jiyoung Lee; Mito Kanatsu-Shinohara; Hiroko Morimoto; Yasuhiro Kazuki; Seiji Takashima; Mitsuo Oshimura; Shinya Toyokuni; Takashi Shinohara
        CELL STEM CELL, 2009年07月, 査読有り
      • Heritable Imprinting Defect Caused by Epigenetic Abnormalities in Mouse Spermatogonial Stem Cells
        Jiyoung Lee; Mito Kanatsu-Shinohara; Narumi Ogonuki; Hiromi Miki; Kimiko Inoue; Takeshi Morimoto; Hiroko Morimoto; Atsuo Ogura; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2009年03月, 査読有り
      • Large-scale production of growing oocytes in vitro from neonatal mouse ovaries
        Arata Honda; Michiko Hirose; Kimiko Inoue; Hitoshi Hiura; Hiromi Miki; Narumi Ogonuki; Michihiko Sugimoto; Kuniya Abe; Mito Kanatsu-Shinohara; Tomohiro Kono; Takashi Shinohara; Atsuo Ogura
        INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2009年, 査読有り
      • spermatogenic defects.
        Takashima S; Takehashi M; Lee J; Chuma S; Okano M; Hata K; Suetake I; Nakatsuji N; Miyoshi H; Tajima S; Tanaka Y; Toyokuni S; Sasaki H; Kanatsu-Shinohara M; Shinohara T
        Biol. Reprod., 2009年, 査読有り
      • Homing of Mouse Spermatogonial Stem Cells to Germline Niche Depends on beta 1-integrin
        Mito Kanatsu-Shinohara; Masanori Takehashi; Seiji Takashima; Jiyoung Lee; Hiroko Morimoto; Shinichiro Chuma; Aurelia Raducanu; Norio Nakatsuji; Reinhard Faessler; Takashi Shinohara
        CELL STEM CELL, 2008年11月, 査読有り
      • Long-term culture of male germline stem cells from hamster testes
        Mito Kanatsu-Shinohara; Tomomi Muneto; Jiyoung Lee; Manami Takenaka; Shinichiro Chuma; Norio Nakatsuji; Toshitaka Horiuchi; Takashi Shinohara
        Biology of Reproduction, 2008年04月, 査読有り
      • Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome
        Y. Kazuki; H. Hoshiya; Y. Kai; S. Abe; M. Takiguchi; M. Osaki; S. Kawazoe; M. Katoh; M. Kanatsu-Shinohara; K. Inoue; N. Kajitani; T. Yoshino; Y. Shirayoshi; A. Ogura; T. Shinohara; J. C. Barrett; M. Oshimura
        GENE THERAPY, 2008年04月, 査読有り
      • Pluripotency of a single spermatogonial stem cell in mice
        Mito Kanatsu-Shinohara; Jiyoung Lee; Kimiko Inoue; Narumi Ogonuki; Hiromi Miki; Shinya Toyokun; Masahito Ikawa; Tomoyuki Nakamura; Atsuo Gura; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2008年04月, 査読有り
      • Brief History, Pitfalls, and Prospects of Mammalian Spermatogonial Stem Cell Research
        M. Kanatsu-Shinohara; M. Takehashi; T. Shinohara
        CONTROL AND REGULATION OF STEM CELLS, 2008年, 査読有り
      • Production of knockout mice by gene targeting in multipotent germline stem cells
        Masanori Takehashi; Mito Kanatsu-Shinohara; Hiromi Miki; Jiyoung Lee; Yasuhiro Kazuki; Kimiko Inoue; Narumi Ogonuki; Shinya Toyokuni; Mitsuo Oshimura; Atsuo Ogura; Takashi Shinohara
        DEVELOPMENTAL BIOLOGY, 2007年12月, 査読有り
      • Isolation, characterization, and in vitro and in vivo differentiation of putative thecal stem cells
        Arata Honda; Michiko Hirose; Kenshiro Hara; Shogo Matoba; Kimiko Inoue; Himomi Miki; Hitoshi Hiura; Mito Kanatsu-Shinohara; Yoshiakira Kanai; Tomohiro Kono; Takashi Shinohara; Atsuo Ogura
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007年07月, 査読有り
      • Generation of cardiac and endothelial cells from neonatal mouse testis-derived multipotent germline stem cells
        Sbiro Baba; Toshio Heike; Katsutsugu Umeda; Toru Iwasa; Shinji Kaichi; Yoshiml Hiraumi; Hiraku Doi; Momoko Yoshimoto; Mito Kanatsu-Shinohara; Takashi Shinohara; Tatsutosbi Nakahata
        STEM CELLS, 2007年06月, 査読有り
      • Akt mediates self-renewal division of mouse spermatogonial stem cells
        Jiyoung Lee; Mito Kanatsu-Shinohara; Kimiko Inoue; Narumi Ogonuki; Hiromi Miki; Shinya Toyokuni; Tohru Kimura; Toru Nakano; Atsuo Ogura; Takashi Shinohara
        DEVELOPMENT, 2007年05月, 査読有り
      • A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells
        Hajime Kurosaki; Yasuhiro Kazuki; Masaharu Hiratsuka; Toshiaki Inoue; Yasuhisa Matsui; Chi Chiu Wang; Mito Kanatsu-Shinohara; Takashi Shinohara; Tosifusa Toda; Mitsuo Oshimura
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007年02月, 査読有り
      • Culture and genetic modification of mouse germline stem cells
        Mito Kanatsu-Shinohara; Takashi Shinohara
        Annals of the New York Academy of Sciences, 2007年, 査読有り
      • Culture and genetic modification of mouse germline stem cells.
        Kanatu-Shinohara M; Shinohara T
        Ann.N.Y.Acad.Sci., 2007年, 査読有り
      • Adenovirus-mediated gene delivery into mouse spermatogonial stem cells.
        Takehashi M; Kanatsu-Shinohara M; Inoue K; Ogonuki N; Miki H; Toyokuni S; Ogura A; Shinohara T
        Proc. Natl. Acad. Sci. USA, 2007年, 査読有り
      • Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture
        Mito Kanatsu-Shinohara; Kimiko Inoue; Narumi Ogonuki; Hiromi Miki; Shosei Yoshida; Shinya Toyokuni; Jiyoung Lee; Atsuo Ogura; Takashi Shinohara
        BIOLOGY OF REPRODUCTION, 2007年01月, 査読有り
      • Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination
        Takashi Shinohara; Megumi Kato; Masanori Takehashi; Jiyoung Lee; Shinichiro Chuma; Norio Nakatsuji; Mito Kanatsu-Shinohara; Masumi Hirabayashi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006年09月, 査読有り
      • Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells
        RS Fujino; YI Ishikawa; K Tanaka; M Kanatsu-Shinohara; K Tamura; H Kogo; T Shinohara; T Hara
        MOLECULAR REPRODUCTION AND DEVELOPMENT, 2006年08月, 査読有り
      • Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells
        Masanori Imamura; Kyoko Miura; Kumiko Iwabuchi; Tomoko Ichisaka; Masato Nakagawa; Jiyoung Lee; Mito Kanatsu-Shinohara; Takashi Shinohara; Shinya Yamanaka
        BMC DEVELOPMENTAL BIOLOGY, 2006年07月, 査読有り
      • Clonal origin of germ cell colonies after spermatogonial transplantation in mice
        M Kanatsu-Shinohara; K Inoue; H Miki; N Ogonuki; M Takehashi; T Morimoto; A Ogura; T Shinohara
        BIOLOGY OF REPRODUCTION, 2006年07月, 査読有り
      • The germ of pluripotency
        M Kanatsu-Shinohara; T Shinohara
        NATURE BIOTECHNOLOGY, 2006年06月, 査読有り
      • Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells
        M Kanatsu-Shinohara; M Ikawa; M Takehashi; N Ogonuki; H Miki; K Inoue; Y Kazuki; J Lee; S Toyokuni; M Oshimura; A Ogura; T Shinohara
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006年05月, 査読有り
      • Anchorage-independent growth of mouse male germline stem cells in vitro
        M Kanatsu-Shinohara; K Inoue; J Lee; H Miki; N Ogonuki; S Toyokuni; A Ogura; T Shinohara
        BIOLOGY OF REPRODUCTION, 2006年03月, 査読有り
      • Genetic and epigenetic properties of mouse male germline stem cells during long-term culture
        M Kanatsu-Shinohara; N Ogonuki; T Iwano; J Lee; Y Kazuki; K Inoue; H Miki; M Takehashi; S Toyokuni; Y Shinkai; M Oshimura; F Ishino; A Ogura; T Shinohara
        DEVELOPMENT, 2005年09月, 査読有り
      • Germline niche transplantation restores fertility in infertile mice
        M Kanatsu-Shinohara; H Miki; K Inoue; N Ogonuki; S Toyokuni; A Ogura; T Shinohara
        HUMAN REPRODUCTION, 2005年09月, 査読有り
      • Long-term culture of mouse male germline stem cells under serum- or feeder-free conditions
        M Kanatsu-Shinohara; H Miki; K Inoue; N Ogonuki; S Toyokuni; A Ogura; T Shinohara
        BIOLOGY OF REPRODUCTION, 2005年04月, 査読有り
      • Male germline stem cells: stem cells for germline modification and regenerative medicine
        T. Shinohara; M. Kanatsu-Shinohara
        Seikagaku. The Journal of Japanese Biochemical Society., 2005年, 査読有り
      • Spermatogenesis from epiblast and primordial germ cells following transplantation into postnatal mouse testis
        S Chuma; M Kanatsu-Shinohara; K Inoue; N Ogonuki; H Miki; S Toyokuni; M Hosokawa; N Nakatsuji; A Ogura; T Shinohara
        DEVELOPMENT, 2005年01月, 査読有り
      • Genetic selection of mouse male germline stem cells in vitro: Offspring from single stem cells
        M Kanatsu-Shinohara; S Toyokuni; T Shinohara
        BIOLOGY OF REPRODUCTION, 2005年01月, 査読有り
      • Generation of pluripotent stem cells from neonatal mouse testis
        M Kanatsu-Shinohara; K Inoue; J Lee; M Yoshimoto; N Ogonuki; H Miki; S Baba; T Kato; Y Kazuki; S Toyokuni; M Toyoshima; O Niwa; M Oshimura; T Heike; T Nakahata; F Ishino; A Ogura; T Shinohara
        CELL, 2004年12月, 査読有り
      • Transgenic mice produced by retroviral transduction of male germ line stem cells in vivo
        M Kanatsu-Shinohara; S Toyokuni; T Shinohara
        BIOLOGY OF REPRODUCTION, 2004年10月, 査読有り
      • Regulation of mouse spermatogonial stem cell self-renewing division by the pituitary gland
        M Kanatsu-Shinohara; T Morimoto; S Toyokuni; T Shinohara
        BIOLOGY OF REPRODUCTION, 2004年06月, 査読有り
      • CD9 is a surface marker on mouse and rat male germline stem cells
        M Kanatsu-Shinohara; S Toyokuni; T Shinohara
        BIOLOGY OF REPRODUCTION, 2004年01月, 査読有り
      • Restoration of fertility in infertile mice by transplantation of cryopreserved male germline stem cells
        M Kanatsu-Shinohara; N Ogonuki; K Inoue; A Ogura; S Toyokuni; T Shinohara
        HUMAN REPRODUCTION, 2003年12月, 査読有り
      • Direct visualization of transplanted hematopoietic cell reconstitution in intact mouse organs indicates the presence of a niche
        M Yoshimoto; T Shinohara; T Heike; M Shiota; M Kanatsu-Shinohara; T Nakahata
        EXPERIMENTAL HEMATOLOGY, 2003年08月, 査読有り
      • Long-term proliferation in culture and germline transmission of mouse male germline stem cells
        M Kanatsu-Shinohara; N Ogonuki; K Inoue; H Miki; A Ogura; S Toyokuni; T Shinohara
        BIOLOGY OF REPRODUCTION, 2003年08月, 査読有り
      • Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation
        M Kanatsu-Shinohara; S Toyokuni; T Morimoto; S Matsui; T Honjo; T Shinohara
        BIOLOGY OF REPRODUCTION, 2003年05月, 査読有り
      • Allogeneic offspring produced by male germ line stem cell transplantation into infertile mouse testis
        M Kanatsu-Shinohara; N Ogonuki; K Inoue; A Ogura; S Toyokuni; T Honjo; T Shinohara
        BIOLOGY OF REPRODUCTION, 2003年01月, 査読有り
      • Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination
        T Shinohara; K Inoue; N Ogonuki; M Kanatsu-Shinohara; H Miki; K Nakata; M Kurome; H Nagashima; S Toyokuni; K Kogishi; T Honjo; A Ogura
        HUMAN REPRODUCTION, 2002年12月, 査読有り
      • Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
        M Kanatsu-Shinohara; A Ogura; M Ikegawa; K Inoue; N Ogonuki; K Tashiro; S Toyokuni; T Honjo; T Shinohara
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002年02月, 査読有り
      • Acquisition of meiotic competence in mouse oocytes: Absolute amounts of p34(cdc2), cyclin b1, cdc25C, and wee1 in meiotically incompetent and competent oocytes
        M Kanatsu-Shinohara; RM Schultz; GS Kopf
        BIOLOGY OF REPRODUCTION, 2000年12月, 査読有り
      • Involvement of the cytoskeleton in the movement of cortical granules during oocyte maturation, and cortical granule anchoring in mouse eggs
        SA Connors; M Kanatsu-Shinohara; RM Schultz; GS Kopf
        DEVELOPMENTAL BIOLOGY, 1998年08月, 査読有り
      • Phenotypic plasticity of mouse spermatogonial stem cells. PLoS One 2009 Nov 19;4(11):e7909
        Morimoto H; Kanatsu-Shionohara M; Takashima S; Chuma S; Nakatsuji N; Shinohara T
      • Production of transgenic rats following lentiviral transduction and xenogeneic transplantation of spermatogonial stem cells.
        Kanatsu-Shinohara M; Kato M; Takehashi M; Hirabayashi M; Shinohara T
        Biol. Reprod., 査読有り

      MISC

      • 精子幹細胞の機能的寿命の維持機構
        篠原 美都; 本田 直樹; 篠原 隆司
        実験医学, 2017年05月, 招待有り
      • 幹細胞からみた生殖系の老化 (特集 細胞老化,臓器老化,組織老化)
        篠原 美都; 篠原 隆司
        Anti-aging medicine, 2013年02月
      • Transcriptional and epigenetic landscape of mouse germline stem cells
        Mihoko Hosokawa; Ami Katanaya; Eri Hayashi; Ayako Mochizuki; Hirofami Suemori; Koji Numata; Kuniya Abe; Takashi Tanaka; Mito Kanatsu-Shinohara; Takashi Shinohara; Norio Nakatsuji; Shinichiro Chuma
        GENES & GENETIC SYSTEMS, 2012年12月
      • マウス生殖幹細胞のゲノムーエピゲノム解析
        細川美穂子; 刀谷在美; 林瑛理; 望月綾子; 末盛博文; 沼田興治; 阿部訓也; 田中敬; 篠原美都; 篠原隆司; 中辻憲夫; 中馬新一郎
        日本遺伝学会第84 回大会(2012.9.26, 福岡), 2012年, 査読有り
      • マウス生殖幹細胞の体細胞型増殖から第一減数分裂前期への移行
        細川美穂子; 田中敬; 林瑛理; 篠原美都; 篠原隆司; 中辻憲夫; 中馬新一郎
        特定領域研究生殖サイクル第4 回公開シンポジウム(11.17-18, 2011, 大阪), 2011年, 査読有り
      • マウス生殖幹細胞の減数分裂移行実験系作出の試み
        細川美穂子; 田中敬; 林瑛理; 篠原美都; 篠原隆司; 中辻憲夫; 中馬新一郎
        特定領域研究「生殖サイクル若手勉強会2010」(2010. 7. 21-23. Tsukuba), 2010年, 査読有り
      • Production of Transgenic Rats via Lentiviral Transduction and Xenogeneic Transplantation of Spermatogonial Stem Cells Editorial Comment
        M. Kanatsu-Shinohara; M. Kato; M. Takehashi; H. Morimoto; S. Takashima; S. Chuma; N. Nakatsuji; M. Hirabayashi; T. Shinohara
        JOURNAL OF UROLOGY, 2009年07月
      • HERITABLE IMPRINTING DEFECT CAUSED BY FETAL MALE GERM CELL CULTURE IN MICE
        Takashi Shinohara; Mito Kanatsu-Shinohara; Jiyoung Lee
        JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009年
      • 精子幹細胞と再生医療
        竹橋正則; 篠原美都; 篠原隆司
        産科と婦人科, 2009年
      • 精子幹細胞による新しい遺伝子改変ストラテジー
        竹橋正則; 篠原美都; 篠原隆司
        実験医学, 2008年
      • トピックス:精子幹細胞の培養と遺伝子改変
        竹橋正則; 篠原美都; 篠原隆司
        最新医学, 2008年
      • 精巣由来体性幹細胞の心筋梗塞モデルへの移植効果
        馬場 志郎; 平家 俊男; 梅田 雄嗣; 岩朝 徹; 鶏内 伸二; 平海 良美; 土井 拓; 吉本 桃子; 篠原 美都; 篠原 隆; 中畑 龍俊
        Inflammation and Regeneration, 2006年07月
      • Functional Restoration of a Genetic Defect in Multipotent Germline Stem Cells by Human Artificial Chromosome Containing a Genomic Insert
        Yasuhiro Kazuki; Hidetoshi Hoshiya; Yoshiteru Kai; Satoshi Abe; Masato Takiguchi; Mitsuhiko Osaki; Mito Kanatsu-Shinohara; Naoyo Kajitani; Yasuaki Shirayoshi; Masaharu Hiratuka; Astuo Ogura; Takashi Shinohara; Mitsuo Oshimura
        MOLECULAR THERAPY, 2006年05月
      • Culture and genetic modification of male mouse germline stem cells.
        Takashi Shinohara; Mito Kanatsu-Shinohara
        BIOLOGY OF REPRODUCTION, 2006年
      • 用語解説:GS細胞
        竹橋正則; 篠原美都; 篠原隆司
        分子細胞治療, 2006年
      • 精巣由来体性幹細胞の中胚葉から心筋,内皮への分化と移植による心機能解析
        馬場 志郎; 平家 俊男; 吉本 桃子; 梅田 雄嗣; 岩朝 徹; 鶏内 伸二; 平海 良美; 土井 拓; 篠原 美都; 篠原 隆; 中畑 龍俊
        炎症・再生, 2005年07月

      講演・口頭発表等

      • 長期培養における精子幹細胞の老化
        篠原 美都
        第1回AMED-CREST機能低下・睡眠グループ分科会, 2018年12月13日
      • 精子を作る幹細胞とその操作技術
        篠原 美都
        日本女性科学者の会 60周年記念シンポジウム, 2018年11月03日
      • 精子幹細胞の老化において精巣支持環境が果たす役割の解明
        篠原 美都
        新学術領域「幹細胞老化と疾患」第5回領域会議, 2018年06月01日
      • 精子幹細胞の自己複製と維持のメカニズムの解明
        篠原 美都
        第23回日本女性科学者の会奨励賞 受賞記念講演, 2018年05月27日, 招待有り
      • 精子幹細胞の寿命制御とアンチエイジング機構
        篠原 美都
        第7回細胞再生医療研究会, 2017年08月19日, 招待有り
      • 精子幹細胞の老化において精巣支持環境が果たす役割の解明
        篠原 美都
        新学術領域「幹細胞老化と疾患」第4回領域会議, 2017年06月28日
      • 精子幹細胞の寿命と精子形成への寄与の動態解明
        篠原 美都
        生命動態システム科学四拠点 合同シンポジウム, 2017年03月18日, 招待有り

      外部資金:科学研究費補助金

      外部資金:その他

      • ホーミングにおける精子幹細胞の動態の分子的解析
        最先端・次世代研究開発支援プログラム
        自 2010年, 至 2013年
        篠原 美都
      • 「精子幹細胞を用いた創薬モデルラットの作成技術の開発」
        H21-23年度 厚生労働科学研究費補助金 創薬基盤推進研究事業 (研究代表者)
        代表
      list
        Last Updated :2022/07/01

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