基本情報

学位

• 博士（医学）(京都大学)

使用言語

• 日本語

ID,URL

• J-Global ID

  201501083249400600

researchmap URL

• https://researchmap.jp/7000011333

研究

研究テーマ・研究概要

• 研究テーマ

  消化管がんのバイオマーカーの開発、大腸発がんと遺伝性腫瘍

• 研究概要

  消化管癌の予防や早期発見による死亡の抑制を主な目標として、がんの早期診断に有用な血液を用いた消化管がんの非侵襲的バイオマーカーの開発、大腸発がんにおける前がん病変である大腸ポリープの生物学的、分子的特徴を明らかにするためのトランスレーショナルリサーチ、がん発症の高リスクである遺伝性腫瘍に関する臨床研究を行っている。

研究分野

• ライフサイエンス, 消化器内科学

論文

• Lynch syndrome screening in patients with young-onset extra-colorectal Lynch syndrome-associated cancers.

  Atsushi Yamada; Yukari Doi; Sachiko Minamiguchi; Tomohiro Kondo; Tomohiko Sunami; Takahiro Horimatsu; Junzo Hamanishi; Masaki Mandai; Etsuro Hatano; Takashi Kobayashi; Shigeo Hisamori; Kazutaka Obama; Hiroshi Seno; Hironori Haga; Masako Torishima; Hiromi Murakami; Takeshi Nakajima; Takahiro Yamada; Shinji Kosugi; Kokichi Sugano; Manabu Muto

  International journal of clinical oncology, 2024年11月

  
• Remarkable response to capmatinib in a patient with intrahepatic cholangiocarcinoma harboring TFG-MET fusion

  Akira Ueta; Atsushi Yamada; Masahiro Yoshioka; Masashi Kanai; Manabu Muto; Natsuko Okita

  International Cancer Conference Journal, 2024年03月09日

  
• Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma

  Trang H. Nguyen Vu; Osamu Kikuchi; Shinya Ohashi; Tomoki Saito; Tomomi Ida; Yukie Nakai; Yang Cao; Yoshihiro Yamamoto; Yuki Kondo; Yosuke Mitani; Shigeki Kataoka; Tomohiro Kondo; Chikatoshi Katada; Atsushi Yamada; Junichi Matsubara; Manabu Muto

  Cancer Science, 2023年09月19日

  
• Exceptional Response of Pancreatic Acinar Cell Carcinoma and Bile Duct Cancer to Platinum-Based Chemotherapy in a Family With a Germline BRCA2 Variant.

  Tomohiko Sunami; Atsushi Yamada; Tomohiro Kondo; Masashi Kanai; Kazuyuki Nagai; Yoichiro Uchida; Masataka Yokode; Tomoaki Matsumori; Norimitsu Uza; Hiromi Murakami; Takahiro Yamada; Manabu Muto

  Pancreas, 2022年10月01日

  
• 多発ヨード不染帯を有する食道早期癌内視鏡切除後患者に対するTS-1療法の食道内多発癌抑制効果に関する検討

  玉置 将司; 堀松 高博; 横山 顕礼; 天沼 裕介; 宮本 心一; 山田 敦; 野村 基雄; 船越 真木子; 松本 繁巳; 大橋 真也; 青山 育雄; 石川 秀樹; 武藤 学

  日本消化管学会雑誌, 2020年01月, 査読有り

  
• HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function.

  Yosuke Mitani; Shinya Ohashi; Osamu Kikuchi; Yukie Nakai; Tomomi Ida; Ayaka Mizumoto; Yoshihiro Yamamoto; Tomoki Saito; Shigeki Kataoka; Junichi Matsubara; Atsushi Yamada; Masashi Kanai; Shigemi Matsumoto; Hiroaki Sakai; Kiyotsugu Yoshikawa; Eijiro Nakamura; Manabu Muto

  Scientific reports, 2022年06月02日

  この論文にアクセスする：

  
• Germline sequencing for presumed germline pathogenic variants via tumor-only comprehensive genomic profiling.

  Tomohiro Kondo; Yoshihiro Yamamoto; Keita Fukuyama; Masashi Kanai; Atsushi Yamada; Junichi Matsubara; Pham Nguyen Quy; Masahiro Yoshioka; Takahiro Yamada; Sachiko Minamiguchi; Shigemi Matsumoto; Shinji Kosugi; Manabu Muto

  International journal of clinical oncology, 2022年05月14日

  
• Real-world outcome of universal screening for Lynch syndrome in Japanese patients with colorectal cancer highlights the importance of targeting patients with young-onset disease.

  Atsushi Yamada; Yui Matsuoka; Sachiko Minamiguchi; Yoshihiro Yamamoto; Tomohiro Kondo; Tomohiko Sunami; Takahiro Horimatsu; Kenji Kawada; Hiroshi Seno; Masako Torishima; Hiromi Murakami; Takahiro Yamada; Shinji Kosugi; Kokichi Sugano; Manabu Muto

  Molecular and clinical oncology, 2021年12月

  
• Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40–69-years subjects

  Shinya Ohashi; Takahisa Maruno; Keita Fukuyama; Osamu Kikuchi; Tomohiko Sunami; Yuki Kondo; Seiichiro Imai; Aki Matsushima; Kazuyo Suzuki; Fumika Usui; Masahiro Yakami; Atsushi Yamada; Hiroyoshi Isoda; Shigemi Matsumoto; Hiroshi Seno; Manabu Muto; Mayumi Inoue

  Esophagus, 2021年06月12日, 査読有り

  この論文にアクセスする：

  
• Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations

  Mitsuhiro Nikaido; Nobuyuki Kakiuchi; Shin’ichi Miyamoto; Tomonori Hirano; Yasuhide Takeuchi; Taro Funakoshi; Akira Yokoyama; Tatsuki Ogasawara; Yoshihiro Yamamoto; Atsushi Yamada; Takeshi Setoyama; Takahiro Shimizu; Yukari Kato; Suguru Uose; Takaki Sakurai; Sachiko Minamiguchi; Kazutaka Obama; Yoshiharu Sakai; Manabu Muto; Tsutomu Chiba; Seishi Ogawa; Hiroshi Seno

  Gastric Cancer, 2021年05月07日, 査読有り

  
• Safety of esophagogastroduodenoscopy in individuals harboring unruptured intracranial aneurysms

  Atsushi Yamada; Mizuho Nishio; Takahisa Maruno; Makiko Funakoshi; Maiko Furukawa

  European Journal of Gastroenterology & Hepatology, 2021年05月, 査読有り, 筆頭著者, 責任著者

  
• Comprehensive genomic profiling for patients with chemotherapy‐naïve advanced cancer

  Tomohiro Kondo; Junichi Matsubara; Pham Nguyen Quy; Keita Fukuyama; Motoo Nomura; Taro Funakoshi; Keitaro Doi; Yuichi Sakamori; Masahiro Yoshioka; Akira Yokoyama; Masashi Tamaoki; Tadayuki Kou; Kenshiro Hirohashi; Atsushi Yamada; Yoshihiro Yamamoto; Sachiko Minamiguchi; Masakazu Nishigaki; Takahiro Yamada; Masashi Kanai; Shigemi Matsumoto; Manabu Muto

  Cancer Science, 2021年01月, 査読有り

  この論文にアクセスする：

  
• Upper Gastrointestinal Langerhans Cell Histiocytosis: A Report of 2 Adult Cases and a Literature Review

  Yui Matsuoka; Yoshiki Iemura; Masakazu Fujimoto; Shinsuke Shibuya; Atsushi Yamada; Shigehiko Fujii; Toshihiro Kusaka; Takero Shindo; Sachiko Minamiguchi; Hironori Haga

  International Journal of Surgical Pathology, 2020年10月09日

  
• Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.

  Kenshiro Hirohashi; Shinya Ohashi; Yusuke Amanuma; Yukie Nakai; Tomomi Ida; Kiichiro Baba; Yosuke Mitani; Ayaka Mizumoto; Yoshihiro Yamamoto; Osamu Kikuchi; Junichi Matsubara; Atsushi Yamada; Shin'ichi Miyamoto; Hiroshi Seno; Tomonari Matsuda; Manabu Muto

  Carcinogenesis, 2020年04月22日, 査読有り

  この論文にアクセスする：

  
• 上部消化管のランゲルハンス細胞組織球症 成人の2症例(Upper gastrointestinal Langerhans cell histiocytosis: report of two adult cases)

  松岡 由; 藤本 正数; 渋谷 信介; 山田 敦; 南口 早智子; 羽賀 博典

  日本病理学会会誌, 2020年03月

  
• Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect.

  Kiichiro Baba; Motoo Nomura; Shinya Ohashi; Takuya Hiratsuka; Yukie Nakai; Tomoki Saito; Yuki Kondo; Keita Fukuyama; Osamu Kikuchi; Atsushi Yamada; Junichi Matsubara; Kenshiro Hirohashi; Yosuke Mitani; Ayaka Mizumoto; Manabu Muto

  American journal of cancer research, 2020年, 査読有り

  
• リンチ症候群の免疫染色スクリーニング(Immunostaining screening for Lynch syndrome)

  松岡 由; 南口 早智子; 山田 敦; 山田 崇弘; 住吉 真治; 片岡 竜貴; 吉澤 明彦; 羽賀 博典

  日本病理学会会誌, 2019年09月

  
• Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer.

  Taro Funakoshi; Shin'ichi Miyamoto; Nobuyuki Kakiuchi; Mitsuhiro Nikaido; Takeshi Setoyama; Akira Yokoyama; Takahiro Horimatsu; Atsushi Yamada; Masako Torishima; Shinji Kosugi; Hidetaka Yamada; Haruhiko Sugimura; Hironori Haga; Yoshiharu Sakai; Seishi Ogawa; Hiroshi Seno; Manabu Muto; Tsutomu Chiba

  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2019年07月, 査読有り

  
• Rectal Submucosal Tumor Mimicking a Neuroendocrine Tumor.

  Takahiro Utsumi; Atsushi Yamada; Takaki Sakurai; Shin'ichi Miyamoto

  Internal medicine (Tokyo, Japan), 2019年05月15日, 査読有り

  この論文にアクセスする：

  
• Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.

  大橋 真也

  J Gastroenterology, 2019年, 査読有り

  
• A RNA-Sequencing approach for the identification of novel long non-coding RNA biomarkers in colorectal cancer.

  Yamada A; Yu P; Lin W; Okugawa Y; Boland CR; Goel A

  Sci Rep, 2018年01月, 査読有り

  
• Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.

  Yoshioka M; Ohashi S; Ida T; Nakai Y; Kikuchi O; Amanuma Y; Matsubara J; Yamada A; Miyamoto S; Natsuizaka M; Nakagawa H; Chiba T; Seno H; Muto M

  Journal of experimental & clinical cancer research : CR, 2017年08月, 査読有り

  
• Factors affecting dilation force in balloon dilation of severe esophageal strictures: an experiment using an artificial stricture model

  Yoshitaka Nishikawa; Hirokazu Higuchi; Osamu Kikuchi; Yasumasa Ezoe; Ikuo Aoyama; Atsushi Yamada; Masataka Kanki; Shuhei Nomura; Motoo Nomura; Takahiro Horimatsu; Manabu Muto

  Surgical Endoscopy, 2016年10月01日, 査読有り

  
• Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal Neoplasia

  Atsushi Yamada; Takahiro Horimatsu; Yoshinaga Okugawa; Naoshi Nishida; Hajime Honjo; Hiroshi Ida; Tadayuki Kou; Toshihiro Kusaka; Yu Sasaki; Makato Yagi; Takuma Higurashi; Norio Yukawa; Yusuke Amanuma; Osamu Kikuchi; Manabu Muto; Yoshiyuki Ueno; Atsushi Nakajima; Tsutomu Chiba; C. Richard Boland; Ajay Goel

  CLINICAL CANCER RESEARCH, 2015年09月, 査読有り

  
• Technical Factors Involved in the Measurement of Circulating MicroRNA Biomarkers for the Detection of Colorectal Neoplasia

  Atsushi Yamada; Mary A. Cox; Kristin A. Gaffney; Amber Moreland; C. Richard Boland; Ajay Goel

  PLOS ONE, 2014年11月, 査読有り

  
• Serum microRNAs as diagnostic biomarkers for early colorectal neoplasms

  Yamada Atsushi; Horimatsu Takahiro; Okugawa Yoshinaga; Nishida Naoshi; Kou Tadayuki; Kusaka Toshihiro; Honjo Hajime; Amanuma Yusuke; Kikuchi Osamu; Muto Manabu; Goel Ajay, Bol; C. Richard

  CANCER RESEARCH, 2014年10月01日, 査読有り

  
• Colorectal Advanced Neoplasms Occur through Dual Carcinogenesis Pathways in Individuals with Coexisting Serrated Polyps

  Atsushi Yamada; Sachiko Minamiguchi; Yoshiharu Sakai; Takahiro Horimatsu; Manabu Muto; Tsutomu Chiba; C. Richard Boland; Ajay Goel

  PLOS ONE, 2014年05月, 査読有り

  
• Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus

  Atsushi Yamada; Satoshi Fujii; Hiroyuki Daiko; Mitsuyo Nishimura; Tsutomu Chiba; Atsushi Ochiai

  INTERNATIONAL JOURNAL OF ONCOLOGY, 2011年02月, 査読有り

  
• Endoscopic Features of Sessile Serrated Adenoma and other Serrated Colorectal Polyps

  Atsushi Yamada; Kenji Notohara; Ikuo Aoyama; Masatsugu Miyoshi; Shinichi Miyamoto; Shigehiko Fujii; Hiroshi Yamamoto

  HEPATO-GASTROENTEROLOGY, 2011年01月, 査読有り

  
• Expression of podoplanin, CD44, and p63 in squamous cell carcinoma of the lung

  Yoshihisa Shimada; Genichiro Ishii; Kanji Nagai; Naho Atsumi; Satoshi Fujii; Atsushi Yamada; Yuki Yamane; Tomoyuki Hishida; Mitsuyo Nishimura; Junji Yoshida; Norihiko Ikeda; Atsushi Ochiai

  CANCER SCIENCE, 2009年11月, 査読有り

  
• Expression of cytokeratin 7 predicts survival in stage I/IIA/IIB squamous cell carcinoma of the esophagus

  Atsushi Yamada; Hiroki Sasaki; Kazuhiko Aoyagi; Masayuki Sano; Satoshi Fujii; Hiroyuki Daiko; Mitsuyo Nishimura; Teruhiko Yoshida; Tsutomu Chiba; Atsushi Ochiai

  ONCOLOGY REPORTS, 2008年11月, 査読有り

  

MISC

• Identification of Novel Colorectal Cancer-Specific miRNA Biomarkers Using Next-Generation Sequencing

  Yoshinaga Okugawa; Yuji Toiyama; Atsushi Yamada; Koji Tanaka; Yasuhiro Inoue; Masato Kusunoki; C. R. Boland; Ajay Goel

  GASTROENTEROLOGY, 2015年04月

  
• Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells

  Masahiro Yoshioka; Shinya Ohashi; Tomomi Ida; Yukie Nakai; Osamu Kikuchi; Yusuke Amanuma; Junichi Matsubara; Atsushi Yamada; Shin'ichi Miyamoto; Mitsuteru Natsuizaka; Hiroshi Nakagawa; Tsutomu Chiba; Hiroshi Seno; Manabu Muto

  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2017年08月

  
• EGFR inhibitors exert different effects on epithelial-like and mesenchymal-like esophageal squamous carcinoma cells

  Masahiro Yoshioka; Shinya Ohashi; Tomomi Ida; Yukie Nakai; Osamu Kikuchi; Yusuke Amanuma; Jun'ichi Matsubara; Atsushi Yamada; Shin'ichi Miyamoto; Manabu Muto

  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016年11月

  
• RNA-Sequencing Approach for the Identification of Novel Long Non-Coding RNA Biomarkers in Colorectal Cancer

  Atsushi Yamada; Yoshinaga Okugawa; C. R. Boland; Ajay Goel

  GASTROENTEROLOGY, 2015年04月

  
• Characterization of Colorectal Advanced Neoplasia That Coexists With Serrated Polyps

  Atsushi Yamada; Sachiko Minamiguchi; C. Richard Boland; Ajay Goel

  GASTROENTEROLOGY, 2013年05月

  

外部資金：科学研究費補助金

• 大腸管状腺腫の遺伝子変異プロファイルおよび生物学的多様性についての研究

  基盤研究(C)

  小区分53010:消化器内科学関連

  京都大学

  山田 敦

  自 2019年04月01日, 至 2022年03月31日, 完了

  大腸管状腺腫;オルガノイド培養;大腸腺腫;遺伝子変異;多様性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08467/
• “Hypermutated-type” 大腸がんの診断バイオマーカーの開発

  基盤研究(C)

  京都大学

  山田 敦

  自 2016年04月01日, 至 2019年03月31日, 完了

  大腸がん;Hypermutated-type;“Hypermutated-type” 大腸がん;「Hypermutated type」大腸癌;内科

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09309/
• 大腸前がん病変におけるSpheroid増殖能の意義とメカニズムの解明

  基盤研究(C)

  小区分50010:腫瘍生物学関連

  京都大学

  山田 敦

  自 2022年04月01日, 至 2025年03月31日, 交付

  大腸管状腺腫;オルガノイド培養;スフェロイド増殖能;大腸前癌病変

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07149/