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服部 雅一

ハットリ マサカズ

医学研究科 がん組織応答共同研究講座(産学共同) 特定教授

服部 雅一
list
    Last Updated :2022/11/23

    基本情報

    学部兼担

    • 医学部

    所属学協会

    • 分子生物学会
    • 癌学会
    • 免疫学会

    学位

    • 獣医学修士(北海道大学)
    • 博士(獣医学)(北海道大学)

    経歴

    • 自 1997年, 至 2004年
      京都大学助教授
    • 自 1992年, 至 1997年
      京都大学助手
    • 自 1988年, 至 1992年
      北海道大学助手
    • 自 1988年, 至 1992年
      Hokkaido University, Research Assistant
    • 自 1983年, 至 1988年
      東レ基礎研究所,研究員
    • 自 1983年, 至 1988年
      Toray. co, Basic Science Institute, Researcher

    使用言語

    • 英語
    • 日本語

    ID,URL

    researchmap URL

    list
      Last Updated :2022/11/23

      研究

      研究テーマ・研究概要

      • 研究テーマ

        免疫老化誘導機構の解明とその制御
      • 研究概要

        加齢に伴う免疫系、特にT細胞の機能低下・変容は癌や感染症リスクの増大のみならず慢性炎症性病態や自己免疫疾患の発症につながっていると考えられてきたが、その詳細なメカニズムは長い間不明であった。我々の研究室では加齢に伴い増加する炎症性状を有するT細胞集団を同定し、老化関連T細胞(senescence-associated T:SA-T細胞) と名付けた。現在、この細胞集団による自己免疫疾患やII型糖尿病などの慢性炎症性病態との関連性に調べるとともに、その制御機構を明らかにし、これらの疾患に対する新しい治療薬の創出をめざし研究を行っている。

      研究キーワード

      • 免疫学
      • Cell Bioligy
      • Immunology

      研究分野

      • ライフサイエンス, 免疫学
      • ライフサイエンス, 細胞生物学

      論文

      • The impact of senescence-associated T cells on immunosenescence and age-related disorders.
        Fukushima Y; Minato N; Hattori M
        Inflammation and Regeneration, 2018年12月, 査読有り, 招待有り
      • The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine.
        Koyu Ito; Akira Nakajima; Yuji Fukushima; Keiichiro Suzuki; Keiko Sakamoto; Yoko Hamazaki; Kouetsu Ogasawara; Nagahiro Minato; Masakazu Hattori
        PloS one, 2017年, 査読有り
      • Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice.
        Keiko Sakamoto; Yuji Fukushima; Koyu Ito; Michiyuki Matsuda; Shigekazu Nagata; Nagahiro Minato; Masakazu Hattori
        Journal of immunology (Baltimore, Md. : 1950), 2016年09月15日, 査読有り
      • A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production
        Suhail Tahir; Yuji Fukushima; Keiko Sakamoto; Kyosuke Sato; Harumi Fujita; Joe Inoue; Toshimitsu Uede; Yoko Hamazaki; Masakazu Hattori; Nagahiro Minato
        JOURNAL OF IMMUNOLOGY, 2015年06月, 査読有り
      • T-cell senescence and autoimmune diseases
        Masakazu Hattori; Nagahiro Minato
        Japanese Journal of Allergology, 2015年, 査読有り
      • Effects of CB-VEGF-A Injection in Rat Flap Models for Improved Survival
        Minekatsu Akimoto; Akira Takeda; Osamu Matsushita; Joe Inoue; Keiko Sakamoto; Masakazu Hattori; Natsuko Kounoike; Eiju Uchinuma
        PLASTIC AND RECONSTRUCTIVE SURGERY, 2013年04月, 査読有り
      • MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes
        Kyoko Hayashida; Kiichi Kajino; Masakazu Hattori; Maura Wallace; Ivan Morrison; Mark I. Greene; Chihiro Sugimoto
        Experimental and Molecular Pathology, 2013年02月, 査読有り
      • SPA-1 controls the invasion and metastasis of human prostate cancer
        Yosuke Shimizu; Yoko Hamazaki; Masakazu Hattori; Keiko Doi; Naoki Terada; Takashi Kobayashi; Yoshinobu Toda; Toshinari Yamasaki; Takahiro Inoue; Yoichiro Kajita; Atsushi Maeno; Tomomi Kamba; Yoshiki Mikami; Toshiyuki Kamoto; Tomomi Yamada; Toru Kanno; Kiyotsugu Yoshikawa; Osamu Ogawa; Nagahiro Minato; Eijiro Nakamura
        CANCER SCIENCE, 2011年04月, 査読有り
      • A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes
        K. Hayashida; M. Hattori; R. Nakao; Y. Tanaka; J.-Y. Kim; N. Inoue; V. Nene; C. Sugimoto
        Molecular and Biochemical Parasitology, 2010年11月, 査読有り
      • Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells
        Yoshinori Katayama; Miho Sekai; Masakazu Hattori; Ichiro Miyoshi; Yoko Hamazaki; Nagahiro Minato
        BLOOD, 2009年08月, 査読有り
      • Isolation of ON Bipolar Cell Genes via hrGFP-coupled Cell Enrichment Using the mGluR6 Promoter
        Yoshiaki Nakajima; Masaki Moriyama; Masakazu Hattori; Nagahiro Minato; Shigetada Nakanishi
        JOURNAL OF BIOCHEMISTRY, 2009年06月, 査読有り
      • Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal
        Satoru Hara; Chiaki Nakaseko; Sho Yamasaki; Masakazu Hattori; Johannes L. Bos; Yasushi Saito; Nagahiro Minato; Takashi Saito
        HEMATOLOGY, 2009年06月, 査読有り
      • Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis
        Nagahiro Minato; Masakazu Hattori
        CANCER SCIENCE, 2009年01月, 査読有り
      • Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alpha beta T-cell development
        Kohei Kometani; Masaki Moriyama; Yasuhiro Nakashima; Yoshinori Katayama; Shu-Fang Wang; Sho Yamasaki; Takashi Saito; Masakazu Hattori; Nagahiro Minato
        BLOOD, 2008年12月, 査読有り
      • Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling
        Shu-Fang Wang; Misayo Aoki; Yasuhiro Nakashima; Yoriko Shinozuka; Hiroki Tanaka; Masafumi Taniwaki; Masakazu Hattori; Nagahiro Minatol
        BLOOD, 2008年03月, 査読有り
      • SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion
        Takanori Kitamura; Kohei Kometani; Hiroki Hashida; Akihiro Matsunaga; Hiroyuki Miyoshi; Hisahiro Hosogi; Masahiro Aoki; Masanobu Oshima; Masakazu Hattori; Arimichi Takabayashi; Nagahiro Minato; Makoto M. Taketo
        NATURE GENETICS, 2007年04月, 査読有り
      • Regulation of immune responses and hematopoiesis by the Rap1 signal
        Nagahiro Minato; Kohei Kometani; Masakazu Hattori
        ADVANCES IN IMMUNOLOGY, VOL 93, 2007年, 査読有り
      • Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model
        Kohei Kometani; Misayo Aoki; Shin Kawamata; Yoriko Shinozuka; Takumi Era; Masafumi Taniwaki; Masakazu Hattori; Nagahiro Minato
        CANCER RESEARCH, 2006年10月, 査読有り
      • BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion
        A. Jin; T. Kurosu; K. Tsuji; D. Mizuchi; A. Arai; H. Fujita; M. Hattori; N. Minato; O. Miura
        ONCOGENE, 2006年07月, 査読有り
      • Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells
        D Ishida; L Su; A Tamura; Y Katayama; Y Kawai; SF Wang; M Taniwaki; Y Hamazaki; M Hattori; N Minato
        IMMUNITY, 2006年04月, 査読有り
      • Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors
        K Masuda; H Kubagawa; T Ikawa; CC Chen; K Kakugawa; M Hattori; R Kageyama; MD Cooper; N Minato; Y Katsura; H Kawamoto
        EMBO JOURNAL, 2005年12月, 査読有り
      • Hes1 directly controls cell proliferation through the transcriptional repression of p27(Kip1)
        K Murata; M Hattori; N Hirai; Y Shinozuka; H Hirata; R Kageyama; T Sakai; N Minato
        MOLECULAR AND CELLULAR BIOLOGY, 2005年05月, 査読有り
      • Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization
        A Farina; M Hattori; J Qin; Y Nakatani; N Minato; K Ozato
        MOLECULAR AND CELLULAR BIOLOGY, 2004年10月, 査読有り
      • Rap1 and SPA-1 in hematologic malignancy
        K Kometani; D Ishida; M Hattori; N Minato
        TRENDS IN MOLECULAR MEDICINE, 2004年08月, 査読有り
      • Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1
        Y Noda; S Horikawa; T Furukawa; K Hirai; Y Katayama; T Asai; M Kuwahara; K Katagiri; T Kinashi; M Hattori; N Minato; S Sasaki
        FEBS LETTERS, 2004年06月, 査読有り
      • Specific recruitment of SPA-1 to the immunological synapse: involvement of actin-bundling protein actinin
        M Harazaki; Y Kawai; L Su; Y Hamazaki; T Nakahata; N Minato; M Hattori
        IMMUNOLOGY LETTERS, 2004年04月, 査読有り
      • Rap1 GTPase: Functions, regulation, and malignancy
        M Hattori; N Minato
        JOURNAL OF BIOCHEMISTRY, 2003年10月, 査読有り
      • Activation of CEA-CAM-1-mediated cell adhesion via CD98: Involvement of PKCδ
        K. Kakugawa; M. Hattori; N. Beauchemin; N. Minato
        FEBS Letters, 2003年09月, 査読有り
      • Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
        D Ishida; K Kometani; HL Yang; K Kakugawa; K Masuda; K Iwai; M Suzuki; S Itohara; T Nakahata; H Hiai; H Kawamoto; M Hattori; N Minato
        CANCER CELL, 2003年07月, 査読有り
      • AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1
        L Su; M Hattori; M Moriyama; N Murata; M Harazaki; K Kaibuchi; N Minato
        JOURNAL OF BIOLOGICAL CHEMISTRY, 2003年04月, 査読有り
      • Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses
        K Katagiri; M Hattori; N Minato; T Kinashi
        MOLECULAR AND CELLULAR BIOLOGY, 2002年02月, 査読有り
      • CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1
        K Suga; K Katagiri; T Kinashi; M Harazaki; T Iizuka; M Hattori; N Minato
        FEBS LETTERS, 2001年02月, 査読有り
      • dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect
        N Ohno; A Izawa; M Hattori; R Kageyama; T Sudo
        STEM CELLS, 2001年, 査読有り
      • Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase
        K Katagiri; M Hattori; N Minato; S Irie; K Takatsu; T Kinashi
        MOLECULAR AND CELLULAR BIOLOGY, 2000年03月, 査読有り
      • Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion
        N Tsukamoto; M Hattori; HL Yang; JL Bos; N Minato
        JOURNAL OF BIOLOGICAL CHEMISTRY, 1999年06月, 査読有り
      • The bHLH gene Hes1 is essential for expansion of early T cell precursors
        K Tomita; M Hattori; E Nakamura; S Nakanishi; N Minato; R Kageyama
        GENES & DEVELOPMENT, 1999年05月, 査読有り
      • Anti-viral and anti-tumor effects induced by an attenuated Marek's disease virus in CD4-or CD8-deficient chickens
        T Morimura; KO Cho; Y Kudo; Y Hiramoto; K Ohashi; M Hattori; C Sugimoto; M Onuma
        ARCHIVES OF VIROLOGY, 1999年, 査読有り
      • Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product
        H Kurachi; Y Wada; N Tsukamoto; M Maeda; H Kubota; M Hattori; K Iwai; N Minato
        JOURNAL OF BIOLOGICAL CHEMISTRY, 1997年10月, 査読有り
      • Phenotype analysis of lymphoid cells in Marek's disease of CD4(+) or CD8(+) T-cell-deficient chickens: occurrence of double negative T-cell tumour
        K Okada; Y Tanaka; K Murakami; S Chiba; T Morimura; M Hattori; M Goryo; M Onuma
        AVIAN PATHOLOGY, 1997年09月, 査読有り
      • Apoptosis in peripheral CD4+T cells and thymocytes by Marek's disease virus-infection
        Toshifumi Morimura
        Leukemia, 1997年, 査読有り
      • Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human
        Y Wada; H Kubota; M Maeda; M Taniwaki; M Hattori; S Imamura; K Iwai; N Minato
        GENOMICS, 1997年01月, 査読有り
      • Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek's disease virus - Brief report
        T Morimura; K Ohashi; Y Kon; M Hattori; C Sugimoto; M Onuma
        ARCHIVES OF VIROLOGY, 1996年, 査読有り
      • Characterization of extrathymic T cells of chickens
        H Yamamoto; M Hattori; K Ohashi; C Sugimoto; M Onuma
        VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1996年01月, 査読有り
      • IMMUNOMODULATION OF PERIPHERAL T-CELLS IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS - INVOLVEMENT IN IMMUNOSUPPRESSION
        T MORIMURA; M HATTORI; K OHASHI; C SUGIMOTO; M ONUMA
        JOURNAL OF GENERAL VIROLOGY, 1995年12月, 査読有り
      • KINETIC-ANALYSIS OF T-CELLS AND ANTIBODY-PRODUCTION IN CHICKENS INFECTED WITH MAREKS-DISEASE VIRUS
        H YAMAMOTO; M HATTORI; K OHASHI; C SUGIMOTO; M ONUMA
        JOURNAL OF VETERINARY MEDICAL SCIENCE, 1995年10月, 査読有り
      • EXPRESSION OF A 32-KILODALTON THEILERIA-SERGENTI PIROPLASM SURFACE PROTEIN BY RECOMBINANT BACULOVIRUSES
        T MATSUBA; C SUGIMOTO; M HATTORI; Y SAKO; K FUJISAKI; M ONUMA
        INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1995年08月, 査読有り
      • MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION
        M HATTORI; N TSUKAMOTO; MSA NUREKAMAL; B RUBINFELD; K IWAI; H KUBOTA; H MARUTA; N MINATO
        MOLECULAR AND CELLULAR BIOLOGY, 1995年01月, 査読有り
      • Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3+CD4-CD8- αβ (V(α)4/V(β)2) T cells
        H. Kubota; M. Sato; Y. Ogawa; K. Iwai; M. Hattori; T. Yoshida; N. Minato
        International Immunology, 1994年09月, 査読有り
      • ANALYSIS OF MIXED PARASITE POPULATIONS OF THEILERIA-SERGENTI USING CDNA PROBES ENCODING A MAJOR PIROPLASM SURFACE PROTEIN
        T MATSUBA; H KUBOTA; M TANAKA; M HATTORI; M MURATA; C SUGIMOTO; M ONUMA
        PARASITOLOGY, 1993年11月, 査読有り
      • CD3+4-8- αβ T cell population with biased T cell receptor v gene usage: Presence in bone marrow and possible involvement of IL-3 for their extrathymic development
        H. Kubota; H. Okazaki; M. Onuma; S. Kano; M. Hattori; N. Minato
        Journal of Immunology, 1992年08月, 査読有り
      • SENSITIVE METHOD FOR THE DETECTION OF ANTIBODIES TO INFECTIOUS HEMATOPOIETIC NECROSIS VIRUS
        WZ ZHUANG; M HATTORI; M ONUMA; H KODAMA
        JOURNAL OF VETERINARY MEDICAL SCIENCE, 1992年04月, 査読有り
      • CHARACTERIZATION OF HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN OF NEWCASTLE-DISEASE VIRUS EXPRESSED BY A RECOMBINANT BACULOVIRUS
        M NIIKURA; Y MATSUURA; M HATTORI; M ONUMA; T MIKAMI
        VIRUS RESEARCH, 1991年06月, 査読有り
      • EXPRESSION OF THE A-ANTIGEN (GP57-65) OF MAREKS-DISEASE VIRUS BY A RECOMBINANT BACULOVIRUS
        M NIIKURA; Y MATSUURA; M HATTORI; M ONUMA; T MIKAMI
        JOURNAL OF GENERAL VIROLOGY, 1991年05月, 査読有り
      • HIGH-MOLECULAR-WEIGHT LY-5 ISOFORMS EXPRESSED ON T-CELLS - ACTIVATION-DEPENDENT EXPRESSION
        Y OGAWA; H OKAZAKI; T SUDO; N OHNO; M ITOH; M HATTORI; M IIZUKA; N MINATO
        INTERNATIONAL IMMUNOLOGY, 1991年01月, 査読有り
      • IDENTIFICATION AND GENE CLONING OF A NEW PHOSPHATIDYLINOSITOL-LINKED ANTIGEN EXPRESSED ON MATURE LYMPHOCYTES - DOWN-REGULATION BY LYMPHOCYTE-ACTIVATION
        H KUBOTA; H OKAZAKI; M ONUMA; S KANO; M HATTORI; N MINATO
        JOURNAL OF IMMUNOLOGY, 1990年12月, 査読有り
      • Expression of murine IL-2 receptor β-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor α-chain transgenic mice
        M. Hattori; H. Okazaki; Y. Ishida; M. Onuma; S. Kano; T. Honjo; N. Minato
        Journal of Immunology, 1990年05月, 査読有り
      • ISOLATION AND EXPRESSION OF THE FULL-LENGTH CDNA-ENCODING CD59 ANTIGEN OF HUMAN-LYMPHOCYTES
        R SAWADA; K OHASHI; H ANAGUCHI; H OKAZAKI; M HATTORI; N MINATO; M NARUTO
        DNA AND CELL BIOLOGY, 1990年04月, 査読有り
      • PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST CHICKEN LYMPHOCYTE SURFACE-ANTIGENS
        T KONDO; M HATTORI; H KODAMA; M ONUMA; T MIKAMI
        JAPANESE JOURNAL OF VETERINARY SCIENCE, 1990年02月, 査読有り
      • Characterization of two monoclonal antibodies which recognize different subpopulations of chicken T lymphocytes.
        T. Kondo; M. Hattori; H. Kodama; M. Onuma; T. Mikami
        Japanese Journal of Veterinary Research, 1990年, 査読有り
      • IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing αβ or γδ T-cell receptors in vitro: Synergism with IL-2
        H. Okazaki; M. Ito; T. Sudo; M. Hattori; S. Kano; Y. Katsura; N. Minato
        Journal of Immunology, 1989年11月, 査読有り
      • EXPANSION OF NATURAL-KILLER CELLS BUT NOT T-CELLS IN HUMAN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTOR (TAC) TRANSGENIC MICE
        Y ISHIDA; M NISHI; O TAGUCHI; K INABA; M HATTORI; N MINATO; M KAWAICHI; T HONJO
        JOURNAL OF EXPERIMENTAL MEDICINE, 1989年10月, 査読有り
      • Developmental regulation of the extrathymic differentiation potential of the progenitor cells for T cell lineage
        Masakazu Hattori; Tetsuo Sudo; Hisao Izawa; Shogo Kano; Nagahiro Minato
        International Immunology, 1989年05月, 査読有り
      • Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C
        R. Sawada; K. Ohashi; K. Okano; M. Hattori; N. Minato; M. Naruto
        Nucleic Acids Research, 1989年, 査読有り
      • DIFFERENTIATION INVITRO OF T3+ LARGE GRANULAR LYMPHOCYTES WITH CHARACTERISTIC CYTO-TOXIC ACTIVITY FROM AN ISOLATED HEMATOPOIETIC PROGENITOR COLONY
        N MINATO; M HATTORI; T SUDO; S KANO; Y MIURA; J SUDA; T SUDA
        JOURNAL OF EXPERIMENTAL MEDICINE, 1988年03月, 査読有り
      • Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3
        M. Hattori; T. Udo; M. Iizuka; S. Kobayashi; S. Nishio; S. Kano; N. Minato
        Journal of Experimental Medicine, 1987年, 査読有り
      • Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines
        K. Ikuta; M. Hattori; K. Wake; S. Kano; T. Honjo; J. Yodoi; N. Minato
        Journal of Experimental Medicine, 1986年, 査読有り

      MISC

      • PD-1+ memory phenotype CD4+ T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia
        K. Shimatani; Y. Nakashima; M. Hattori; Y. Hamazaki; N. Minato
        Proceedings of the National Academy of Sciences of the United States of America, 2009年09月, 査読有り
      • Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice
        D Ishida; HL Yang; K Masuda; K Uesugi; H Kawamoto; M Hattori; N Minato
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003年09月, 査読有り

      講演・口頭発表等

      • 老化関連T細胞の誘導メカニズムとその制御
        服部 雅一
        日本炎症・再生医学会, 2017年07月18日, 招待有り

      産業財産権

      • 特許5996437, 特願2012-548828, 抗原特異的モノクローナル抗体産生ハイブリドーマの作成方法及び抗原特異的モノクローナル抗体の製造作成
        服部雅一; 井上 浄; 赤澤悠子
      • 特願2010-110694, 粘膜,上皮および鼓膜の少なくとも一つの再生材および再生評価方法
        宮下武憲; 森望,西望; 安達栄治郎; 松下治; 服部雅一; 伊藤周平; 坂本恵子
      • 特許3683000, SPA-1蛋白質及びそれをコードする遺伝子

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