基本情報

学部兼担

• 医学部

学位

• Ｐｈ．Ｄ.(ロンドン大学)

使用言語

• 英語

ID,URL

• J-Global ID

  201401065142602655

researchmap URL

• https://researchmap.jp/7000008426

研究

研究テーマ・研究概要

• 研究テーマ

  癌遺伝学、ゲノムワイド関連解析(GWAS)

• 研究概要

  ヒトゲノムの塩基配列には、個人間、人種間で微妙な違いが多数存在する。これら塩基の個体差を多型と呼び、そのうち一塩基の多型 (Single Nucleotide Polymorphism: SNP) はヒトゲノム上で数百塩基に一箇所の割合で存在し、疾患と個人の遺伝的素因の関係を調べる有用なツールとなっている。近年ではDNAチップの開発により全ゲノム関連解析(GWAS)が可能になった。患者と対照群について数十万個のSNP遺伝子型データを一度に決定し、両群で有意差を認めるSNPを探索することにより疾患発症に重要な影響を及ぼす遺伝子多型が同定可能である。我々の目的はGWASを用いて、様々な多因子型遺伝病の感受性遺伝子多型を同定し、その情報を基に高危険群診断法の確立することである。

研究分野

• ライフサイエンス, ゲノム生物学

論文

• 対象地域を拡大してベラルーシとウクライナから集めた試料によるチェルノブイリ原子力発電事故に起因した甲状腺癌の分子疫学的な研究(Molecular epidemiology study of Chernobyl thyroid cancer in an extended sample set from Belarus and Ukraine)

  サエンコ・ウラジミール; 高橋 めい子; ログノビッチ・タチアナ; ドロズド・ワレンティナ; デミチク・ユーリ; ボグダノワ・タチアナ; トロンコ・ミコラ; 光武 範吏; 高村 昇; 松田 文彦; 山下 俊一

  日本内分泌学会雑誌, 2012年09月

  
• 染色体2q35における一般的なSNP rs966423は病因特異的で散発性甲状腺癌だけのリスクを生じさせるのか(Is the common SNP rs966423 at chromosome 2q35 etiology-specific and confers risk for sporadic thyroid cancer only?)

  ログノビッチ・タチアナ; サエンコ・ウラジミル; Tatsiana Leonava; Valentina Drozd; 高橋 めい子; 川口 喬久; 光武 範吏; 松田 文彦; 山下 俊一

  日本内分泌学会雑誌, 2017年12月

  
• 染色体2q35におけるcommon SNP rs966423は病因特異的であり散発性甲状腺癌のみの危険性の原因となるのか(Is the common SNP rs966423 at chromosome 2q35 etiology-specific and confers risk for sporadic thyroid cancer only?)

  ログノビッチ・タチアナ; サエンコ・ウラジミル; Leonava Tatsiana; Drozd Valentina; Demidchik Yuri; 高橋 めい子; 川口 喬久; 光武 範吏; 松田 文彦; 山下 俊一

  日本内分泌学会雑誌, 2017年04月

  
• 日本人とベラルーシ人の集団の遺伝子型解析から甲状腺乳頭がんに対してrs965513とrs1867277遺伝子多型は独立に影響を及ぼすことは明らかだが、FOXE1のポリアラニン領域長が危険度に影響を及ぼす役割を持つとは言えない(Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma)

  ニキツキー・アリャクサンドル; サエンコ・ウラジミル; ログノビッチ・タチアナ; ビチコブ・アンドレイ; 高橋 めい子; 吉浦 孝一郎; 光武 範吏; 川口 喬久; 松瀬 美智子; ドロズド・ワレンチナ; デミドチック・ユリ; 西原 永潤; 廣川 満良; 宮内 昭; ルバノビッチ・アレクサンドル; 松田 文彦; 山下 俊一

  日本内分泌学会雑誌, 2016年04月

  
• rs944289の稀なTアリルは悪性だけでなく良性の甲状腺腫の発症危険性と関連している(Rare T allele of rs944289 associates not only with risk of malignant but also of benign thyroid tumors)

  ログノビッチ・タチアナ; サエンコ・ウラジミール; ビチコブ・アンドレイ; ニキツキー・アリャクサンドル; 高橋 めい子; 中島 正洋; 林 徳眞吉; 廣川 満良; 宮内 昭; 石垣 克; 重松 和人; 松瀬 美智子; 光武 範吏; 西原 永潤; 南 恵樹; 山之内 孝彰; 伊藤 正博; 吉浦 孝一郎; 松田 文彦; 山下 俊一

  日本内分泌学会雑誌, 2014年04月

  
• ベラルーシ人と日本人におけるFOXE1遺伝子の3種の遺伝子多型と甲状腺乳頭癌の関連(Association of three polymorphisms of the FOXE1 gene with papillary thyroid carcinoma in Belarussian and Japanese populations)

  サエンコ・ウラジミール; 高橋 めい子; ログノビッチ・タチアナ; ドロズド・ワレンチナ; ビチコブ・アンドレイ; 川口 喬久; 光武 範吏; 廣川 満良; 西原 永潤; 宮内 昭; 吉浦 孝一郎; 松田 文彦; 山下 俊一

  日本内分泌学会雑誌, 2013年09月

  
• 日本人患者における染色体14q13.3座における遺伝子多型は甲状腺濾胞腺腫の危険度と関連している(Genetic polymorphism on chromosome 14q13.3 associates with risk for thyroid follicular adenoma in Japanese patients)

  ログノビッチ・タチアナ; サエンコ・ウラジミール; ビチコブ・アンドレイ; ニキツキー・アリャクサンドル; 高橋 めい子; 中島 正洋; 林 徳眞吉; 廣川 満良; 宮内 昭; 石垣 克; 重松 和人; 光武 範吏; 伊藤 正博; 松田 文彦; 山下 俊一

  日本内分泌学会雑誌, 2013年09月

  
• チェルノブイリ事故後のNRG1遺伝子と甲状腺がんの発症危険度と関連性(Association of the NRG1 gene with risk for developing thyroid cancer after Chernobyl)

  サエンコ・ウラジミール; 高橋 めい子; ログノビッチ・タチアナ; ドロズド・ワレンティナ; デミドチク・ユーリ; ボグダノワ・タチアナ; トロンコ・ミコラ; 光武 範吏; 高村 昇; 松田 文彦; 山下 俊一

  日本内分泌学会雑誌, 2013年04月

  
• Transcriptomic Analysis Reveals Sixteen Potential Genes Associated with the Successful Differentiation of Antibody-Secreting Cells through the Utilization of Unfolded Protein Response Mechanisms in Robust Responders to the Influenza Vaccine.

  Ahmed Tawfik; Takahisa Kawaguchi; Meiko Takahashi; Kazuya Setoh; Izumi Yamaguchi; Yasuharu Tabara; Kristel Van Steen; Anavaj Sakuntabhai; Fumihiko Matsuda

  Vaccines, 2024年01月29日

  
• Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study.

  Yoshika Tsuji; Tomohiro Koga; Fumiaki Nonaka; Kenichi Nobusue; Shin-Ya Kawashiri; Hirotomo Yamanashi; Takahiro Maeda; Kazuhiko Arima; Kiyoshi Aoyagi; Meiko Takahashi; Shuji Kawaguchi; Fumihiko Matsuda; Hiroshi Fujii; Mitsuhiro Kawano; Hiroyuki Nakamura; Atsushi Kawakami; Mami Tamai

  Frontiers in immunology, 2023年, 査読有り

  
• Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.

  Kazuyoshi Ishigaki; Saori Sakaue; Chikashi Terao; Yang Luo; Kyuto Sonehara; Kensuke Yamaguchi; Tiffany Amariuta; Chun Lai Too; Vincent A Laufer; Ian C Scott; Sebastien Viatte; Meiko Takahashi; Koichiro Ohmura; Akira Murasawa; Motomu Hashimoto; Hiromu Ito; Mohammed Hammoudeh; Samar Al Emadi; Basel K Masri; Hussein Halabi; Humeira Badsha; Imad W Uthman; Xin Wu; Li Lin; Ting Li; Darren Plant; Anne Barton; Gisela Orozco; Suzanne M M Verstappen; John Bowes; Alexander J MacGregor; Suguru Honda; Masaru Koido; Kohei Tomizuka; Yoichiro Kamatani; Hiroaki Tanaka; Eiichi Tanaka; Akari Suzuki; Yuichi Maeda; Kenichi Yamamoto; Satoru Miyawaki; Gang Xie; Jinyi Zhang; Christopher I Amos; Edward Keystone; Gertjan Wolbink; Irene van der Horst-Bruinsma; Jing Cui; Katherine P Liao; Robert J Carroll; Hye-Soon Lee; So-Young Bang; Katherine A Siminovitch; Niek de Vries; Lars Alfredsson; Solbritt Rantapää-Dahlqvist; Elizabeth W Karlson; Sang-Cheol Bae; Robert P Kimberly; Jeffrey C Edberg; Xavier Mariette; Tom Huizinga; Philippe Dieudé; Matthias Schneider; Martin Kerick; Joshua C Denny; Koichi Matsuda; Keitaro Matsuo; Tsuneyo Mimori; Fumihiko Matsuda; Keishi Fujio; Yoshiya Tanaka; Atsushi Kumanogoh; Matthew Traylor; Cathryn M Lewis; Stephen Eyre; Huji Xu; Richa Saxena; Thurayya Arayssi; Yuta Kochi; Katsunori Ikari; Masayoshi Harigai; Peter K Gregersen; Kazuhiko Yamamoto; S Louis Bridges Jr; Leonid Padyukov; Javier Martin; Lars Klareskog; Yukinori Okada; Soumya Raychaudhuri

  Nature genetics, 2022年11月

  
• Automated identification of single nucleotide polymorphisms from sequencing data

  M Takahashi; F Matsuda; N Margetic; M Lathrop

  CSB2002: IEEE COMPUTER SOCIETY BIOINFORMATICS CONFERENCE, 2002年, 査読有り

  
• Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis

  Kazuyoshi Ishigaki; Saori Sakaue; Chikashi Terao; Yang Luo; Kyuto Sonehara; Kensuke Yamaguchi; Tiffany Amariuta; Chun Lai Too; Vincent A Laufer; Ian C Scott; Sebastien Viatte; Meiko Takahashi; Koichiro Ohmura; Akira Murasawa; Motomu Hashimoto; Hiromu Ito; Mohammed Hammoudeh; Samar Al Emadi; Basel K Masri; Hussien Halabi; Humeria Badsha; Imad W Uthman; Xin Wu; Li Lin; Ting Lin; Darren Plant; Anne Barton; Gisela Orozco; Suzanne MM Verstappen; John Bowes; Alexander J MacGregor; Suguru Honda; Masaru Koido; Kohei Tomizuka; Yoichiro Kamatani; Hiroaki Tanaka; Eiichi Tanaka; Akari Suzuki; Yuichi Maeda; Kenichi Yamamoto; Satoru Miyawaki; Gang Xie; Jinyi Zhang; Chris Amos; Ed Keystone; Gertjan Wolbink; Irene van der Horst-Bruinsma; Jing Cui; Katherine P Liao; Robert J Carroll; Hye-Soon Lee; So-Young Bang; Katherine A Siminovitch; Niek de Vries; Lars Alfredsson; Solbritt Rantapää-Dahlqvist; Elizabeth W Karlson; Sang-Cheol Bae; Robert P Kimberly; Jeffrey C Edberg; Xavier Mariette; Tom Huizinga; Philippe Dieudé; Matthias Schneider; Martin Kerick; Joshua C Denny; Koichi Matsuda; Keitaro Matsuo; Tsuneyo Mimori; Fumihiko Matsuda; Keishi Fujio; Yoshiya Tanaka; Atsushi Kumanogoh; Matthew Traylor; Cathryn M Lewis; Stephen Eyre; Huji Xu; Richa Saxena; Thurayya Arayssi; Yuta Kochi; Katsunori Ikari; Masayoshi Harigai; Peter K Gregersen; Kazuhiko Yamamoto; S. Louis Bridges; Leonid Padyukov; Javier Martin; Lars Klareskog; Yukinori Okada; Soumya Raychaudhuri

  2021年12月05日, 査読有り

  
• Improved genetic prediction of the risk of knee osteoarthritis using the risk factor-based polygenic score.

  Yugo Morita; Yoichiro Kamatani; Hiromu Ito; Shiro Ikegawa; Takahisa Kawaguchi; Shuji Kawaguchi; Meiko Takahashi; Chikashi Terao; Shuji Ito; Kohei Nishitani; Shinichiro Nakamura; Shinichi Kuriyama; Yasuharu Tabara; Fumihiko Matsuda; Shuichi Matsuda

  Arthritis research & therapy, 2023年06月12日

  
• Genetic influences on human blood metabolites in the Japanese population

  Takeshi Iwasaki; Yoichiro Kamatani; Kazuhiro Sonomura; Shuji Kawaguchi; Takahisa Kawaguchi; Meiko Takahashi; Koichiro Ohmura; Taka-Aki Sato; Fumihiko Matsuda

  iScience, 2023年01月, 査読有り

  この論文にアクセスする：

  
• Trivalent Inactivated Influenza Vaccine Response and Immunogenicity Assessment after One Week and Three Months in Repeatedly Vaccinated Adults

  Ahmed Tawfik; Takahisa Kawaguchi; Meiko Takahashi; Kazuya Setoh; Izumi Yamaguchi; Yasuharu Tabara; Kristel Van Steen; Anavaj Sakuntabhai; Fumihiko Matsuda

  2022年09月14日

  
• The association between the Moyamoya disease susceptible gene RNF213 variant and incident cardiovascular disease in a general population: the Nagahama study.

  Yasuharu Tabara; Hitomi Yamada; Kazuya Setoh; Manami Matsukawa; Meiko Takahashi; Takahisa Kawaguchi; Takeo Nakayama; Fumihiko Matsuda; Shinji Kosugi

  Journal of hypertension, 2021年12月01日

  
• Genome wide association study of HTLV-1–associated myelopathy/tropical spastic paraparesis in the Japanese population

  Marina Penova; Shuji Kawaguchi; Jun-ichirou Yasunaga; Takahisa Kawaguchi; Tomoo Sato; Meiko Takahashi; Masakazu Shimizu; Mineki Saito; Kunihiro Tsukasaki; Masanori Nakagawa; Norihiro Takenouchi; Hideo Hara; Eiji Matsuura; Satoshi Nozuma; Hiroshi Takashima; Shuji Izumo; Toshiki Watanabe; Kaoru Uchimaru; Masako Iwanaga; Atae Utsunomiya; Yasuharu Tabara; Richard Paul; Yoshihisa Yamano; Masao Matsuoka; Fumihiko Matsuda

  Proceedings of the National Academy of Sciences, 2021年03月16日

  
• Association of ALPL variants with serum alkaline phosphatase and bone traits in the general Japanese population: The Nagahama Study.

  Miho Nagata; Kazuya Setoh; Meiko Takahashi; Koichiro Higasa; Takahisa Kawaguchi; Hidenori Kawasaki; Takahito Wada; Atsushi Watanabe; Hideaki Sawai; Yasuharu Tabara; Takahiro Yamada; Fumihiko Matsuda; Shinji Kosugi

  Journal of human genetics, 2020年03月, 査読有り

  
• IgG4-related disease in the Japanese population: a genome-wide association study

  Chikashi Terao; Masao Ota; Takeshi Iwasaki; Masahiro Shiokawa; Shuji Kawaguchi; Katsutoshi Kuriyama; Takahisa Kawaguchi; Yuzo Kodama; Izumi Yamaguchi; Kazushige Uchida; Koichiro Higasa; Motohisa Yamamoto; Kensuke Kubota; Shujiro Yazumi; Kenji Hirano; Yasufumi Masaki; Hiroyuki Maguchi; Tomoki Origuchi; Shoko Matsui; Takahiro Nakazawa; Hideyuki Shiomi; Terumi Kamisawa; Osamu Hasebe; Eisuke Iwasaki; Kazuo Inui; Yoshiya Tanaka; Koh ichi Ohshima; Takashi Akamizu; Shigeo Nakamura; Seiji Nakamura; Takako Saeki; Hisanori Umehara; Tooru Shimosegawa; Nobumasa Mizuno; Mitsuhiro Kawano; Atsushi Azumi; Hiroki Takahashi; Tsuneyo Mimori; Yoichiro Kamatani; Kazuichi Okazaki; Tsutomu Chiba; Shigeyuki Kawa; Fumihiko Matsuda; Atsushi Kanno; Yoshihiro Okabe; Shinji Katsushima; Tetsuro Inokuma; Yukitaka Yamashita; Yoshitaka Nakai; Takayoshi Nishino; Kozo Kajimura; Mitsushige Shibatoge; Naoki Kanda; Akio Ido; Masaya Ohana; Ichiro Moriyama; Hiroshi Tatsuta; Kazuyoshi Matsumura; Keita Fujikawa; Norimoto Gotoh; Takanobu Tsutsumi; Masakazu Shimizu; Kazuya Setoh; Meiko Takahashi; Yasuharu Tabara; Jun Mimura; Takefumi Nakamura; Toshiyuki Kimura; Chiharu Kawanami

  The Lancet Rheumatology, 2019年09月, 査読有り

  
• 患者の年齢および腫瘍の原因に関する甲状腺癌のリスクをもたらす4つの遺伝子座の評価(Assessment of 4 genetic loci conferring risk for thyroid cancer with regard to patient's age and tumor etiology)

  Rogounovitch Tatiana; 光武 範吏; Leonava Tatsiana; Drozd Valentina; 高橋 めい子; 松田 文彦; 山下 俊一; Saenko Vladimir

  日本内分泌学会雑誌, 2019年04月

  
• 小児における被曝関連甲状腺癌のリスクは他の年齢集団またはベラルーシの他の被曝状況の集団とは異なりDIRC3 SNPと関連しない(The DIRC3 SNP does not associate with the risk for radiation-related thyroid cancer in children in contrast to other age or exposure-status groups from Belarus)

  Rogounovitch Tatiana; Saenko Vladimir; Leonava Tatsiana; Drozd Valentina; Takahashi Meiko; Kawaguchi Takahisa; Mitsutake Norisato; Matsuda Fumihiko; Yamashita Shunichi

  日本放射線影響学会大会講演要旨集, 2018年11月

  
• Takayasu Arteritis and Ulcerative Colitis - High Concurrence Ratio and Genetic Overlap.

  Chikashi Terao; Takayoshi Matsumura; Hajime Yoshifuji; Yohei Kirino; Yasuhiro Maejima; Yoshikazu Nakaoka; Meiko Takahashi; Eisuke Amiya; Natsuko Tamura; Toshiki Nakajima; Tomoki Origuchi; Tetsuya Horita; Mitsuru Matsukura; Yuta Kochi; Akiyoshi Ogimoto; Motohisa Yamamoto; Hiroki Takahashi; Shingo Nakayamada; Kazuyoshi Saito; Yoko Wada; Ichiei Narita; Yasushi Kawaguchi; Hisashi Yamanaka; Koichiro Ohmura; Tatsuya Atsumi; Kazuo Tanemoto; Tetsuro Miyata; Masataka Kuwana; Issei Komuro; Yasuharu Tabara; Atsuhisa Ueda; Mitsuaki Isobe; Tsuneyo Mimori; Fumihiko Matsuda

  ARTHRITIS & RHEUMATOLOGY, 2014年10月, 査読有り

  
• Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

  X. Prieur; L. Dollet; M. Takahashi; M. Nemani; B. Pillot; C. Le May; C. Mounier; H. Takigawa-Imamura; D. Zelenika; F. Matsuda; B. Feve; J. Capeau; M. Lathrop; P. Costet; B. Cariou; J. Magre

  DIABETOLOGIA, 2013年08月, 査読有り

  
• Clinical and pathological findings of interstitial lung disease patients with anti-aminoacyl-tRNA synthetase autoantibodies.

  Koreeda Y; Higashimoto I; Yamamoto M; Takahashi M; Kaji K; Fujimoto M; Kuwana M; Fukuda Y

  Internal medicine (Tokyo, Japan), 2010年, 査読有り

  
• Detection of APC gene deletion by double competitive polymerase chain reaction in patients with familial adenomatous polyposis

  M. Takahashi; M. Kikuchi; N. Ohkura; H. Yaguchi; Y. Nagamura; S. Ohnami; M. Ushiama; T. Yoshida; K. Sugano; T. Iwama; S. Kosugi; T. Tsukada

  International Journal of Oncology, 2006年08月, 査読有り

  
• cDNA Microarrayを用いたβ-カテニン下流遺伝子A3966の同定とその機能解析

  藤田 学; 石黒 秀行; 三輪 晋智; 林 裕民; 高橋 めい子; 浜本 隆二; 柳生 隆一郎; 田中 敏博; 角田 達彦; 小川 道雄

  日本癌学会総会記事, 2001年09月, 査読有り

  
• cDNA Microarrayを用いたβ-カテニン下流遺伝子A6069の同定とその解析

  三輪 晋智; 石黒 秀行; 藤田 学; 林 裕民; 高橋 めい子; 浜本 隆二; 柳生 隆一郎; 下川 卓志; 田中 敏博; 角田 達彦

  日本癌学会総会記事, 2001年09月, 査読有り

  
• Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II.

  Kinashi, T; Harada, N; Severinson, E; Tanabe, T; Sideras, P; Konishi, M; Azuma, C; Tominaga, A; Bergstedt-Li; qvist, S; Takahashi, M; Matsuda, F; Yaoita, Y; Takatsu, K; Honjo, T

  Nature, 1986年, 査読有り

  
• Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population.

  Imaizumi A; Adachi Y; Kawaguchi T; Higasa K; Tabara Y; Sonomura K; Sato TA; Takahashi M; Mizukoshi T; Yoshida HO; Kageyama N; Okamoto C; Takasu M; Mori M; Noguchi Y; Shimba N; Miyano H; Yamada R; Matsuda F

  European journal of human genetics : EJHG, 2019年04月, 査読有り

  
• Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis.

  Chikashi Terao; Hajime Yoshifuji; Takayoshi Matsumura; Taeko K Naruse; Tomonori Ishii; Yoshikazu Nakaoka; Yohei Kirino; Keitaro Matsuo; Tomoki Origuchi; Masakazu Shimizu; Yasuhiro Maejima; Eisuke Amiya; Natsuko Tamura; Takahisa Kawaguchi; Meiko Takahashi; Kazuya Setoh; Koichiro Ohmura; Ryu Watanabe; Tetsuya Horita; Tatsuya Atsumi; Mitsuru Matsukura; Tetsuro Miyata; Yuta Kochi; Toshio Suda; Kazuo Tanemoto; Akira Meguro; Yukinori Okada; Akiyoshi Ogimoto; Motohisa Yamamoto; Hiroki Takahashi; Shingo Nakayamada; Kazuyoshi Saito; Masataka Kuwana; Nobuhisa Mizuki; Yasuharu Tabara; Atsuhisa Ueda; Issei Komuro; Akinori Kimura; Mitsuaki Isobe; Tsuneyo Mimori; Fumihiko Matsuda

  Proceedings of the National Academy of Sciences of the United States of America, 2018年12月18日, 査読有り

  
• Prediction model for pancreatic cancer risk in the general Japanese population.

  Nakatochi M; Lin Y; Ito H; Hara K; Kinoshita F; Kobayashi Y; Ishii H; Ozaka M; Sasaki T; Sasahira N; Morimoto M; Kobayashi S; Ueno M; Ohkawa S; Egawa N; Kuruma S; Mori M; Nakao H; Wang C; Nishiyama T; Kawaguchi T; Takahashi M; Matsuda F; Kikuchi S; Matsuo K

  PloS one, 2018年, 査読有り

  この論文にアクセスする：

  
• Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers

  Takahisa Kawaguchi; Toshihide Shima; Masayuki Mizuno; Yasuhide Mitsumoto; Atsushi Umemura; Yoshihiro Kanbara; Saiyu Tanaka; Yoshio Sumida; Kohichiro Yasui; Meiko Takahashi; Keitaro Matsuo; Yoshito Itoh; Katsutoshi Tokushige; Etsuko Hashimoto; Kendo Kiyosawa; Masanori Kawaguchi; Hiroyuki Itoh; Hirofumi Uto; Yasuji Komorizono; Ken Shirabe; Shiro Takami; Toshinari Takamura; Miwa Kawanaka; Ryo Yamada; Fumihiko Matsuda; Takeshi Okanoue

  PLoS ONE, 2018年01月01日, 査読有り

  この論文にアクセスする：

  
• Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.

  Chikashi Terao; Takahisa Kawaguchi; Philippe Dieude; John Varga; Masataka Kuwana; Marie Hudson; Yasushi Kawaguchi; Marco Matucci-Cerinic; Koichiro Ohmura; Gabriela Riemekasten; Aya Kawasaki; Paolo Airo; Tetsuya Horita; Akira Oka; Eric Hachulla; Hajime Yoshifuji; Paola Caramaschi; Nicolas Hunzelmann; Murray Baron; Tatsuya Atsumi; Paul Hassoun; Takeshi Torii; Meiko Takahashi; Yasuharu Tabara; Masakazu Shimizu; Akiko Tochimoto; Naho Ayuzawa; Hidetoshi Yanagida; Hiroshi Furukawa; Shigeto Tohma; Minoru Hasegawa; Manabu Fujimoto; Osamu Ishikawa; Toshiyuki Yamamoto; Daisuke Goto; Yoshihide Asano; Masatoshi Jinnin; Hirahito Endo; Hiroki Takahashi; Kazuhiko Takehara; Shinichi Sato; Hironobu Ihn; Soumya Raychaudhuri; Katherine Liao; Peter Gregersen; Naoyuki Tsuchiya; Valeria Riccieri; Inga Melchers; Gabriele Valentini; Anne Cauvet; Maria Martinez; Tsuneyo Mimori; Fumihiko Matsuda; Yannick Allanore

  Annals of the rheumatic diseases, 2017年06月, 査読有り

  
• Genotype Analyses in the Japanese and Belarusian Populations Reveal Independent Effects of rs965513 and rs1867277 but Do Not Support the Role of FOXE1 Polyalanine Tract Length in Conferring Risk for Papillary Thyroid Carcinoma

  Alyaksandr V. Nikitski; Tatiana I. Rogounovitch; Andrey Bychkov; Meiko Takahashi; Koh-ichiro Yoshiura; Norisato Mitsutake; Takahisa Kawaguchi; Michiko Matsuse; Valentina M. Drozd; Yuri Demidchik; Eijun Nishihara; Mitsuyoshi Hirokawa; Akira Miyauchi; Alexander V. Rubanovich; Fumihiko Matsuda; Shunichi Yamashita; Vladimir A. Saenko

  THYROID, 2017年02月, 査読有り

  
• Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic Obstructive Pulmonary Disease in A General Japanese Population The Nagahama Study

  Shigeo Muro; Yasuharu Tabara; Hisako Matsumoto; Kazuya Setoh; Takahisa Kawaguchi; Meiko Takahashi; Isao Ito; Yutaka Ito; Kimihiko Murase; Chikashi Terao; Shinji Kosugi; Ryo Yamada; Akihiro Sekine; Takeo Nakayama; Kazuo Chin; Michiaki Mishima; Fumihiko Matsuda

  MEDICINE, 2016年04月, 査読有り

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• Descriptive epidemiology of spot urine sodium-to-potassium ratio clarified close relationship with blood pressure level: the Nagahama study

  Yasuharu Tabara; Yoshimitsu Takahashi; Kyoko Kumagai; Kazuya Setoh; Takahisa Kawaguchi; Meiko Takahashi; Yuki Muraoka; Akitaka Tsujikawa; Norimoto Gotoh; Chikashi Terao; Ryo Yamada; Shinji Kosugi; Akihiro Sekine; Nagahisa Yoshimura; Takeo Nakayama; Fumihiko Matsuda

  JOURNAL OF HYPERTENSION, 2015年12月, 査読有り

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• Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis

  Chikashi Terao; Noriyuki Yamakawa; Koichiro Yano; Iris M. Markusse; Katsunori Ikari; Shinji Yoshida; Moritoshi Furu; Motomu Hashimoto; Hiromu Ito; Takao Fujii; Koichiro Ohmura; Kosaku Murakami; Meiko Takahashi; Masahide Hamaguchi; Yasuharu Tabara; Atsuo Taniguchi; Shigeki Momohara; Soumya Raychaudhuri; Cornelia F. Allaart; Hisashi Yamanaka; Tsuneyo Mimori; Fumihiko Matsuda

  ARTHRITIS & RHEUMATOLOGY, 2015年12月, 査読有り

  
• The 8q24 rs6983267G variant is associated with increased thyroid cancer risk

  Ruta Sahasrabudhe; Ana Estrada; Paul Lott; Lynn Martin; Guadalupe Polanco Echeverry; Alejandro Velez; Gila Neta; Meiko Takahasi; Vladimir Saenko; Norisato Mitsutake; Emma Jaeguer; Carlos Simon Duque; Alejandro Rios; Mabel Bohorquez; Rodrigo Prieto; Angel Criollo; Magdalena Echeverry; Ian Tomlinson; Luis G. Carvajal Carmona

  ENDOCRINE-RELATED CANCER, 2015年10月, 査読有り

  
• Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels

  Kazuya Setoh; Chikashi Terao; Shigeo Muro; Takahisa Kawaguchi; Yasuharu Tabara; Meiko Takahashi; Takeo Nakayama; Shinji Kosugi; Akihiro Sekine; Ryo Yamada; Michiaki Mishima; Fumihiko Matsuda

  NATURE COMMUNICATIONS, 2015年07月, 査読有り

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• Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study

  Chikashi Terao; Keita Asai; Motomu Hashimoto; Toru Yamazaki; Koichiro Ohmura; Akihiko Yamaguchi; Katsu Takahashi; Noriko Takei; Takanori Ishii; Takahisa Kawaguchi; Yasuharu Tabara; Meiko Takahashi; Takeo Nakayama; Shinji Kosugi; Akihiro Sekine; Takao Fujii; Ryo Yamada; Tsuneyo Mimori; Fumihiko Matsuda; Kazuhisa Bessho

  JOURNAL OF AUTOIMMUNITY, 2015年05月, 査読有り

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• Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population

  Chikashi Terao; Koichiro Ohmura; Yuta Kochi; Katsunori Ikari; Yukinori Okada; Masakazu Shimizu; Naoshi Nishina; Akari Suzuki; Keiko Myouzen; Takahisa Kawaguchi; Meiko Takahashi; Kiyoshi Takasugi; Akira Murasawa; Shinichi Mizuki; Mitsuhiro Iwahashi; Keiko Funahashi; Masamitsu Natsumeda; Moritoshi Furu; Motomu Hashimoto; Hiromu Ito; Takao Fujii; Kazuhiko Ezawa; Tsukasa Matsubara; Tsutomu Takeuchi; Michiaki Kubo; Ryo Yamada; Atsuo Taniguchi; Hisashi Yamanaka; Shigeki Momohara; Kazuhiko Yamamoto; Tsuneyo Mimori; Fumihiko Matsuda

  ARTHRITIS RESEARCH & THERAPY, 2015年04月, 査読有り

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• BRIEF REPORT Takayasu Arteritis and Ulcerative Colitis: High Rate of Co-Occurrence and Genetic Overlap

  Chikashi Terao; Takayoshi Matsumura; Hajime Yoshifuji; Yohei Kirino; Yasuhiro Maejima; Yoshikazu Nakaoka; Meiko Takahashi; Eisuke Amiya; Natsuko Tamura; Toshiki Nakajima; Tomoki Origuchi; Tetsuya Horita; Mitsuru Matsukura; Yuta Kochi; Akiyoshi Ogimoto; Motohisa Yamamoto; Hiroki Takahashi; Shingo Nakayamada; Kazuyoshi Saito; Yoko Wada; Ichiei Narita; Yasushi Kawaguchi; Hisashi Yamanaka; Koichiro Ohmura; Tatsuya Atsumi; Kazuo Tanemoto; Tetsuro Miyata; Masataka Kuwana; Issei Komuro; Yasuharu Tabara; Atsuhisa Ueda; Mitsuaki Isobe; Tsuneyo Mimori; Fumihiko Matsuda

  ARTHRITIS & RHEUMATOLOGY, 2015年08月, 査読有り

  
• The Common Genetic Variant rs944289 on Chromosome 14q13.3 Associates with Risk of Both Malignant and Benign Thyroid Tumors in the Japanese Population

  Tatiana I. Rogounovitch; Andrey Bychkov; Meiko Takahashi; Norisato Mitsutake; Masahiro Nakashima; Alyaksandr V. Nikitski; Tomayoshi Hayashi; Mitsuyoshi Hirokawa; Katsu Ishigaki; Kazuto Shigematsu; Tetiana Bogdanova; Michiko Matsuse; Eijun Nishihara; Shigeki Minami; Kosho Yamanouchi; Masahiro Ito; Takahisa Kawaguchi; Hisayoshi Kondo; Noboru Takamura; Yasuhiro Ito; Akira Miyauchi; Fumihiko Matsuda; Shunichi Yamashita; Vladimir A. Saenko

  THYROID, 2015年03月, 査読有り

  
• Lack of association between the BIM deletion polymorphism and the risk of lung cancer with and without EGFR mutations.

  Hiromichi Ebi; Isao Oze; Takayuki Nakagawa; Hidemi Ito; Satoyo Hosono; Fumihiko Matsuda; Meiko Takahashi; Shinji Takeuchi; Yukinori Sakao; Toyoaki Hida; Anthony C Faber; Hideo Tanaka; Yasushi Yatabe; Tetsuya Mitsudomi; Seiji Yano; Keitaro Matsuo

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015年01月, 査読有り

  
• Effects of Smoking and Shared Epitope on the Production of Anti-Citrullinated Peptide Antibody in a Japanese Adult Population

  Chikashi Terao; Koichiro Ohmura; Katsunori Ikari; Takahisa Kawaguchi; Meiko Takahashi; Kazuya Setoh; Takeo Nakayama; Shinji Kosugi; Akihiro Sekine; Yasuharu Tabara; Atsuo Taniguchi; Shigeki Momohara; Hisashi Yamanaka; Ryo Yamada; Fumihiko Matsuda; Tsuneyo Mimori

  ARTHRITIS CARE & RESEARCH, 2014年12月, 査読有り

  
• Association Between Antinuclear Antibodies and the HLA Class II Locus and Heterogeneous Characteristics of Staining Patterns The Nagahama Study

  Chikashi Terao; Koichiro Ohmura; Ryo Yamada; Takahisa Kawaguchi; Masakazu Shimizu; Yasuharu Tabara; Meiko Takahashi; Kazuya Setoh; Takeo Nakayama; Shinji Kosugi; Akihiro Sekine; Fumihiko Matsuda; Tsuneyo Mimori

  ARTHRITIS & RHEUMATOLOGY, 2014年12月, 査読有り

  
• A genome-wide association study of serum levels of prostate-specific antigen in the Japanese population

  Chikashi Terao; Naoki Terada; Keitaro Matsuo; Takahisa Kawaguchi; Koji Yoshimura; Norio Hayashi; Masakazu Shimizu; Norihito Soga; Meiko Takahashi; Yoshihiko Kotoura; Ryo Yamada; Osamu Ogawa; Fumihiko Matsuda

  JOURNAL OF MEDICAL GENETICS, 2014年08月, 査読有り

  
• Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases

  Kosuke Tanaka; Chikashi Terao; Koichiro Ohmura; Meiko Takahashi; Ran Nakashima; Yoshitaka Imura; Hajime Yoshifuji; Naoichiro Yukawa; Takashi Usui; Takao Fujii; Tsuneyo Mimori; Fumihiko Matsuda

  JOURNAL OF HUMAN GENETICS, 2014年02月, 査読有り

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• Genome-Wide Association Study of Genetic Factors Related to Confectionery Intake: Potential Roles of the ADIPOQ Gene

  Kenji Wakai; Keitaro Matsuo; Fumihiko Matsuda; Ryo Yamada; Meiko Takahashi; Takahisa Kawaguchi; Yasushi Yatabe; Hidemi Ito; Satoyo Hosono; Kazuo Tajima; Mariko Naito; Emi Morita; Guang Yin; Tatsuhiko Sakamoto; Naoyuki Takashima; Sadao Suzuki; Noriko Nakahata; Haruo Mikami; Keizo Ohnaka; Yoshiyuki Watanabe; Kokichi Arisawa; Michiaki Kubo; Nobuyuki Hamajima; Hideo Tanaka

  OBESITY, 2013年11月, 査読有り

  
• Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population

  Chikashi Terao; Hajime Yoshifuji; Akinori Kimura; Takayoshi Matsumura; Koichiro Ohmura; Meiko Takahashi; Masakazu Shimizu; Takahisa Kawaguchi; Zhiyong Chen; Taeko K. Naruse; Aiko Sato-Otsubo; Yusuke Ebana; Yasuhiro Maejima; Hideyuki Kinoshita; Kosaku Murakami; Daisuke Kawabata; Yoko Wada; Ichiei Narita; Junichi Tazaki; Yasushi Kawaguchi; Hisashi Yamanaka; Kimiko Yurugi; Yasuo Miura; Taira Maekawa; Seishi Ogawa; Issei Komuro; Ryozo Nagai; Ryo Yamada; Yasuharu Tabara; Mitsuaki Isobe; Tsuneyo Mimori; Fumihiko Matsuda

  AMERICAN JOURNAL OF HUMAN GENETICS, 2013年08月, 査読有り

  
• Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

  Takahisa Kawaguchi; Yoshio Sumida; Atsushi Umemura; Keitaro Matsuo; Meiko Takahashi; Toshinari Takamura; Kohichiroh Yasui; Toshiji Saibara; Etsuko Hashimoto; Miwa Kawanaka; Sumio Watanabe; Sumio Kawata; Yasuharu Imai; Miki Kokubo; Toshihide Shima; Hyohun Park; Hideo Tanaka; Kazuo Tajima; Ryo Yamada; Fumihiko Matsuda; Takeshi Okanoue

  PLOS ONE, 2012年06月, 査読有り

  
• Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

  Yukinori Okada; Chikashi Terao; Katsunori Ikari; Yuta Kochi; Koichiro Ohmura; Akari Suzuki; Takahisa Kawaguchi; Eli A. Stahl; Fina A. S. Kurreeman; Nao Nishida; Hiroko Ohmiya; Keiko Myouzen; Meiko Takahashi; Tetsuji Sawada; Yuichi Nishioka; Masao Yukioka; Tsukasa Matsubara; Shigeyuki Wakitani; Ryota Teshima; Shigeto Tohma; Kiyoshi Takasugi; Kota Shimada; Akira Murasawa; Shigeru Honjo; Keitaro Matsuo; Hideo Tanaka; Kazuo Tajima; Taku Suzuki; Takuji Iwamoto; Yoshiya Kawamura; Hisashi Tanii; Yuji Okazaki; Tsukasa Sasaki; Peter K. Gregersen; Leonid Padyukov; Jane Worthington; Katherine A. Siminovitch; Mark Lathrop; Atsuo Taniguchi; Atsushi Takahashi; Katsushi Tokunaga; Michiaki Kubo; Yusuke Nakamura; Naoyuki Kamatani; Tsuneyo Mimori; Robert M. Plenge; Hisashi Yamanaka; Shigeki Momohara; Ryo Yamada; Fumihiko Matsuda; Kazuhiko Yamamoto

  NATURE GENETICS, 2012年05月, 査読有り

  
• Genome-wide association study of the genetic factors related to confectionery intake: potential roles of the ADIPOQ gene

  Wakai,K; Matsuo,K; Matsuda,F; Yamada,R; Takahashi,M

  Obesity (Silver Spring). doi: 10.1002, 2012年02月14日, 査読有り

  
• A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations

  Roubila Meziani; Ryo Yamada; Meiko Takahashi; Kenei Ohigashi; Akio Morinobu; Chikashi Terao; Hitomi Hiratani; Koichiro Ohmura; Masao Yamaguchi; Takashi Nomura; Alexandre Vasilescu; Miki Kokubo; Victor Renault; Katsura Hirosawa; Chanavee Ratanajaraya; Simon Heath; Tsuneyo Mimori; Shimon Sakaguchi; Mark Lathrop; Inga Melchers; Shunichi Kumagai; Fumihiko Matsuda

  MODERN RHEUMATOLOGY, 2012年02月, 査読有り

  
• Transcriptional factor Prox1 plays an essential role in the antiproliferative action of interferon-γ in esophageal cancer cells.

  Akagami M; Kawada K; Kubo H; Kawada M; Takahashi M; Kaganoi J; Kato S; Itami A; Shimada Y; Watanabe G; Sakai Y

  Annals of surgical oncology, 2011年12月, 査読有り

  
• The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population

  Michiko Matsuse; Meiko Takahashi; Norisato Mitsutake; Eijun Nishihara; Mitsuyoshi Hirokawa; Takahisa Kawaguchi; Tatiana Rogounovitch; Vladimir Saenko; Andrey Bychkov; Keiji Suzuki; Keitaro Matsuo; Kazuo Tajima; Akira Miyauchi; Ryo Yamada; Fumihiko Matsuda; Shunichi Yamashita

  JOURNAL OF MEDICAL GENETICS, 2011年09月, 査読有り

  
• The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population

  Michiko Matsuse; Meiko Takahashi; Norisato Mitsutake; Eijun Nishihara; Mitsuyoshi Hirokawa; Takahisa Kawaguchi; Tatiana Rogounovitch; Vladimir Saenko; Andrey Bychkov; Keiji Suzuki; Keitaro Matsuo; Kazuo Tajima; Akira Miyauchi; Ryo Yamada; Fumihiko Matsuda; Shunichi Yamashita

  JOURNAL OF MEDICAL GENETICS, 2011年09月, 査読有り

  
• A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males

  Chanavee Ratanajaraya; Hiroyuki Nishiyama; Meiko Takahashi; Takahisa Kawaguchi; Ryoichi Saito; Yoshiki Mikami; Mikita Suyama; Mark Lathrop; Ryo Yamada; Osamu Ogawa; Fumihiko Matsuda

  JOURNAL OF HUMAN GENETICS, 2011年08月, 査読有り

  
• The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population

  Chikashi Terao; Ryo Yamada; Koichiro Ohmura; Meiko Takahashi; Takahisa Kawaguchi; Yuta Kochi; Yukinori Okada; Yusuke Nakamura; Kazuhiko Yamamoto; Inga Melchers; Mark Lathrop; Tsuneyo Mimori; Fumihiko Matsuda

  HUMAN MOLECULAR GENETICS, 2011年07月, 査読有り

  
• Myelin Basic Protein as a Novel Genetic Risk Factor in Rheumatoid Arthritis-A Genome-Wide Study Combined with Immunological Analyses

  Chikashi Terao; Koichiro Ohmura; Masaki Katayama; Meiko Takahashi; Miki Kokubo; Gora Diop; Yoshinobu Toda; Natsuki Yamamoto; Reiko Shinkura; Masakazu Shimizu; Ivo Gut; Simon Heath; Inga Melchers; Toshiaki Manabe; Mark Lathrop; Tsuneyo Mimori; Ryo Yamada; Fumihiko Matsuda

  PLOS ONE, 2011年06月, 査読有り

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• A Trans-ethnic genetic study of Rheumatoid Arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations. Mod Rheumatol. 2011 May 24.

  Meziani, R; Yamada, R; Takahashi, M; Ohigashi, K

  2011年, 査読有り

  
• The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population

  Chikashi Terao; Ryo Yamada; Koichiro Ohmura; Meiko Takahashi; Takahisa Kawaguchi; Yuta Kochi; Yukinori Okada; Yusuke Nakamura; Kazuhiko Yamamoto; Inga Melchers; Mark Lathrop; Tsuneyo Mimori; Fumihiko Matsuda

  HUMAN MOLECULAR GENETICS, 2011年07月, 査読有り

  
• The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl

  Meiko Takahashi; Vladimir A. Saenko; Tatiana I. Rogounovitch; Takahisa Kawaguchi; Valentina M. Drozd; Hisako Takigawa-Imamura; Natallia M. Akulevich; Chanavee Ratanajaraya; Norisato Mitsutake; Noboru Takamura; Larisa I. Danilova; Maxim L. Lushchik; Yuri E. Demidchik; Simon Heath; Ryo Yamada; Mark Lathrop; Fumihiko Matsuda; Shunichi Yamashita

  HUMAN MOLECULAR GENETICS, 2010年06月, 査読有り

  
• Immunohistochemical detection of the lymphatic marker podoplanin in diverse types of human cancer cells using a novel antibody

  Tomoya Kono; Masayuki Shimoda; Meiko Takahashi; Kyoichi Matsumoto; Takanobu Yoshimoto; Mika Mizutani; Chiharu Tabata; Kae Okoshi; Hiromi Wada; Hajime Kubo

  INTERNATIONAL JOURNAL OF ONCOLOGY, 2007年09月, 査読有り

  
• RNA mutations of prox1 detected in human esophageal cancer cells by the shifted termination assay

  Takanobu Yoshimoto; Meiko Takahashi; Satoshi Nagayama; Go Watanabe; Yutaka Shimada; Yoshiharu Sakasi; Hailme Kubo

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007年07月, 査読有り

  
• Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice

  Chiharu Tabata; Rie Tabata; Yoshio Kadokawa; Shigeo Hisamori; Meiko Takahashi; Michiaki Mishima; Takashi Nakano; Hajime Kubo

  JOURNAL OF IMMUNOLOGY, 2007年07月, 査読有り

  
• Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells

  Meiko Takahashi; Takanobu Yoshimoto; Masayuki Shimoda; Tomoya Kono; Masayuki Koizumi; Shujiro Yazumi; Yutaka Shimada; Ryuichiro Doi; Tsutomu Chiba; Hajime Kubo

  NEOPLASIA, 2006年12月, 査読有り

  
• All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis

  Chiharu Tabata; Yoshio Kadokawa; Rie Tabata; Meiko Takahashi; Kae Okoshi; Yoshiharu Sakai; Michiaki Mishima; Hajime Kubo

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006年12月, 査読有り

  
• A homeobox protein, Prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma

  Masayuki Shimoda; Meiko Takahashi; Takanobu Yoshimoto; Tomoya Kono; Iwao Ikai; Hajime Kubo

  CLINICAL CANCER RESEARCH, 2006年10月, 査読有り

  
• Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells.

  Tomoya Kono; Hajime Kubo; Chikashi Shimazu; Yoshihide Ueda; Meiko Takahashi; Kentoku Yanagi; Naoya Fujita; Takashi Tsuruo; Hiromi Wada; Jun K Yamashita

  Arteriosclerosis, thrombosis, and vascular biology, 2006年09月, 査読有り

  
• Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer

  M Takahashi; Y Nakamura; K Obama; Y Furukawa

  INTERNATIONAL JOURNAL OF ONCOLOGY, 2005年12月, 査読有り

  
• Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer

  M Takahashi; YM Lin; Y Nakamura; Y Furukawa

  ONCOGENE, 2004年12月, 査読有り

  
• Molecular mechanisms of lymphangiogenesis

  M Takahashi; T Yoshimoto; H Kubo

  INTERNATIONAL JOURNAL OF HEMATOLOGY, 2004年07月, 査読有り

  
• Two cases of the caudal duplication anomaly including a discordant monozygotic twin

  HY Kroes; M Takahashi; RJ Zijlstra; JALL Baert; KA Kooi; RMW Hofstra; AJ van Essen

  AMERICAN JOURNAL OF MEDICAL GENETICS, 2002年11月, 査読有り

  
• Isolation of a novel human gene, APCDD1, as a direct target of the beta-catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis

  M Takahashi; M Fujita; Y Furukawa; R Hamamoto; T Shimokawa; N Miwa; M Ogawa; Y Nakamura

  CANCER RESEARCH, 2002年10月, 査読有り

  
• Isolation of a novel human gene, APCDD1, as a direct target of the beta-catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis

  M Takahashi; M Fujita; Y Furukawa; R Hamamoto; T Shimokawa; N Miwa; M Ogawa; Y Nakamura

  CANCER RESEARCH, 2002年10月, 査読有り

  
• Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers

  M Takahashi; T Tsunoda; M Seiki; Y Nakamura; Y Furukawa

  ONCOGENE, 2002年08月, 査読有り

  
• Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours

  N Leonard; R Chaggar; C Jones; M Takahashi; A Nikitopoulou; Lakhani, SR

  JOURNAL OF CLINICAL PATHOLOGY, 2001年09月, 査読有り

  
• Isolation of a novel human gene, ARHGAP9, encoding a Rho-GTPase activating protein

  Y Furukawa; T Kawasoe; Y Daigo; T Nishiwaki; H Ishiguro; M Takahashi; J Kitayama; Y Nakamura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001年06月, 査読有り

  
• Identification of the familial cylindromatosis tumour-suppressor gene

  GR Bignell; W Warren; S Seal; M Takahashi; E Rapley; R Barfoot; H Green; C Brown; PJ Biggs; Lakhani, SR; C Jones; J Hansen; E Blair; B Hofmann; R Siebert; G Turner; DG Evans; C Schrander-Stumpel; FA Beemer; A van den Ouweland; D Halley; B Delpech; MG Cleveland; Leigh, I; J Leisti; S Rasmussen; MR Wallace; C Fenske; P Banerjee; N Oiso; R Chaggar; S Merrett; N Leonard; M Huber; D Hohl; P Chapman; J Burn; S Swift; A Smith; A Ashworth; MR Stratton

  NATURE GENETICS, 2000年06月, 査読有り

  
• Linkage and LOH studies in 19 cylindromatosis families show no evidence of genetic heterogeneity and refine the CYLD locus on chromosome 16q12-q13

  M Takahashi; E Rapley; PJ Biggs; Lakhani, SR; D Cooke; J Hansen; E Blair; B Hofmann; R Siebert; G Turner; DG Evans; C Schrander-Stumpel; FA Beemer; WA van Vloten; MH Breuning; A van den Ouweland; D Halley; B Delpech; M Cleveland; Leigh, I; P Chapman; J Burn; D Hohl; JP Gorog; S Seal; J Mangion; W Warren; G Bignell; MR Stratton

  HUMAN GENETICS, 2000年01月, 査読有り

  

MISC

• ANTI-CITRULLINATED PEPTIDE/PROTEIN ANTIBODY (ACPA)-NEGATIVE RA SHARES LARGE PROPORTION OF SUSCEPTIBILITY GENES WITH ACPA-POSITIVE RA

  C. Terao; K. Ohmura; K. Ikari; Y. Kochi; Y. Okada; M. Shimizu; T. Kawaguchi; M. Takahashi; K. Myouzen; A. Suzuki; M. Kubo; R. Yamada; A. Taniguchi; H. Yamanaka; S. Momohara; K. Yamamoto; F. Matsuda; T. Mimori

  ANNALS OF THE RHEUMATIC DISEASES, 2014年06月

  
• HTLV-1高浸淫地域における大規模HLA解析による感染およびHAM/TSP発症リスクの関連解析

  川口修治; ペノヴァ マリナ; 川口喬久; 清水正和; 高橋めい子; 日笠幸一郎; 日笠幸一郎; 松田文彦

  日本HTLV-1学会学術集会, 2018年

  
• Rheumatoid Factor Is Associated with the Distribution of Hand Joint Destruction in a Dose-Dependent Manner

  Chikashi Terao; Noriyuki Yamakawa; Koichiro Yano; I. M. Markusse; Katsunori Ikari; Shinji Yoshida; Moritoshi Furu; Motomu Hashimoto; Hiromu Ito; Takao Fujii; Koichiro Ohmura; Kosaku Murakami; Meiko Takahashi; Masahide Hamaguchi; Yasuharu Tabara; Atsuo Taniguchi; Shigeki Momohara; Soumya Raychaudhuri; Cornelia F. Allaart; Hisashi Yamanaka; Tsuneyo Mimori; Fumihiko Matsuda

  ARTHRITIS & RHEUMATOLOGY, 2015年10月

  
• DNA damage response genes as genetic factors modifying risk of radiation-related thyroid cancer

  Vladimir Saenko; Tatiana Rogounovitch; Meiko Takahashi; Chanavee Ratanajaraya; Norisato Mitsutake; Valentina Drozd; Fumihiko Matsuda; Shunichi Yamashita

  ENDOCRINE JOURNAL, 2010年03月

  
• チェルノブイリコホートの全ゲノム関連解析による放射線誘発甲状腺がん感受性遺伝子の同定

  高橋めい子; ウラジミール サイエンコ; タチアナ ログノビッチ; 川口喬久; シャナウィー ラタナジャーン; 今村寿子; バレンティナ ドロズド; マーク ラスロップ; 山田亮; 山下俊一; 山下俊一; 松田文彦

  日本人類遺伝学会大会プログラム・抄録集, 2010年

  
• チェルノブイリコホートのゲノムワイド解析による放射線誘発甲状腺がん感受性遺伝子の同定

  高橋めい子; SAENKO Vladimir; RATANAJARAYA Chanavee; 今村寿子; 川口喬久; ROGOUNOVITCH Tatiana; DROZD Valentina; 山田亮; 山田亮; 山下俊一; 松田文彦

  日本人類遺伝学会大会プログラム・抄録集, 2009年

  
• 肺がんの全ゲノム関連解析

  川口喬久; 高橋めい子; 松尾恵太郎; 今村寿子; 園部誠; 黄政龍; 横見瀬裕保; 豊岡伸一; 伊達洋至; 田島和雄; 山田亮; 山田亮; 松田文彦

  日本人類遺伝学会大会プログラム・抄録集, 2009年

  
• A lymphatic differentiation master gene, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma

  Masayuki Shimoda; Meiko Takahashi; Takanobu Yoshimoto; Tomoya Kono; Iwao Ikai; Hajime Kubo

  GASTROENTEROLOGY, 2007年04月

  
• A-to-I RNA editing of a homeobox gene in a subset of human cancer cells

  Meiko Takahashi; Takanobu Yoshimoto; Hajime Kubo

  CLINICAL & EXPERIMENTAL METASTASIS, 2007年

  
• Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer (vol 23, pg 9289, 2004)

  M Takahashi; YM Lin; Y Nakamura; Y Furukawa

  ONCOGENE, 2005年06月

  
• Loss of heterozygosity on chromosome 16q (cylindromatosis gene locus-Cyld1) in sporadic skin adenexal tumours

  N Leonard; R Chaggar; C Jones; M Takahashi; Lakhani, SR

  JOURNAL OF PATHOLOGY, 2000年03月

  
• Fine mapping of the gene for familial cylindromatosis.

  M Takahashi; G Bignell; E Rapley; S Seal; C Brown; P Biggs; W Warren; M Stratton

  AMERICAN JOURNAL OF HUMAN GENETICS, 1999年10月

  
• A SINGLE MISSENSE MUTATION IN CODON-918 OF THE RET PROTOONCOGENE IN SPORADIC MEDULLARY-THYROID CARCINOMAS

  S MAEDA; H NAMBA; N TAKAMURA; K TANIGAWA; M TAKAHASHI; S NOGUCHI; S NAGATAKI; T KANEMATSU; S YAMASHITA

  ENDOCRINE JOURNAL, 1995年04月

  

外部資金：科学研究費補助金

• 日本人におけるEGFR遺伝子変異型肺がんリスクに関連する遺伝子の解明

  基盤研究(C)

  京都大学

  高橋 めい子; 児玉めい子

  自 2016年04月01日, 至 2019年03月31日, 完了

  EGFR変異;肺がん;GWAS;SNP;MiSeq;遺伝子;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08640/
• チェルノブイリコホートの全ゲノム解析による放射線誘発甲状腺がん感受性遺伝子の同定

  若手研究(B)

  京都大学

  高橋 めい子

  自 2009年04月01日, 至 2011年03月31日, 完了

  ゲノム医科学;GWAS;甲状腺がん;SNP;甲状線がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790337/
• 新規癌抑制遺伝子PROX1の機能解析と臨床への応用

  基盤研究(C)

  京都大学

  高橋 めい子

  自 2006年04月01日, 至 2008年03月31日, 完了

  PROX1;癌抑制遺伝子;RNA編集;Prox1, PROX1;Tumor suppressor gene;RNA editing

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590730/
• ES細胞からのリンパ管内皮細胞分化と腫瘍リンパ管特異的な標的分子の探索

  若手研究(B)

  京都大学

  高橋 めい子

  自 2004年04月01日, 至 2007年03月31日, 完了

  ES細胞;血管新生;リンパ管新生

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16790418/

外部資金：その他

• チェルノブイリコホートの全ゲノム解析による放射線誘発甲状腺がん感受性遺伝子の同定

  財団法人藤原記念財団奨励金

  自 2010年, 至 2011年

  高橋めい子

教育

担当科目

• 自 2015年04月, 至 2016年03月

  ゲノムコホート研究（LIMS）

  前期集中, 医学研究科
• 自 2016年04月, 至 2017年03月

  ゲノムコホート研究（LIMS）

  前期集中, 医学研究科
• 自 2017年04月, 至 2018年03月

  ゲノムコホート研究

  前期, 工学研究科
• 自 2017年04月, 至 2018年03月

  ゲノムコホート研究（LIMS）

  前期集中, 医学研究科
• 自 2018年04月, 至 2019年03月

  ゲノムコホート研究

  前期, 工学研究科
• 自 2018年04月, 至 2019年03月

  ゲノムコホート研究（LIMS）

  前期集中, 医学研究科
• 自 2019年04月, 至 2020年03月

  ゲノムコホート研究（LIMS）

  前期集中, 医学研究科