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高橋 めい子

タカハシ メイコ

学際融合教育研究推進センター スーパーグローバルコース医学生命系ユニット 特定講師

高橋 めい子
list
    Last Updated :2022/05/14

    基本情報

    学部兼担

    • 医学部

    学位

    • Ph.D.(ロンドン大学)

    使用言語

    • 英語

    ID,URL

    researchmap URL

    list
      Last Updated :2022/05/14

      研究

      研究テーマ・研究概要

      • 研究テーマ

        癌遺伝学、ゲノムワイド関連解析(GWAS)
      • 研究概要

        ヒトゲノムの塩基配列には、個人間、人種間で微妙な違いが多数存在する。これら塩基の個体差を多型と呼び、そのうち一塩基の多型 (Single Nucleotide Polymorphism: SNP) はヒトゲノム上で数百塩基に一箇所の割合で存在し、疾患と個人の遺伝的素因の関係を調べる有用なツールとなっている。近年ではDNAチップの開発により全ゲノム関連解析(GWAS)が可能になった。患者と対照群について数十万個のSNP遺伝子型データを一度に決定し、両群で有意差を認めるSNPを探索することにより疾患発症に重要な影響を及ぼす遺伝子多型が同定可能である。我々の目的はGWASを用いて、様々な多因子型遺伝病の感受性遺伝子多型を同定し、その情報を基に高危険群診断法の確立することである。

      論文

      • Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population.
        Imaizumi A; Adachi Y; Kawaguchi T; Higasa K; Tabara Y; Sonomura K; Sato TA; Takahashi M; Mizukoshi T; Yoshida HO; Kageyama N; Okamoto C; Takasu M; Mori M; Noguchi Y; Shimba N; Miyano H; Yamada R; Matsuda F
        European journal of human genetics : EJHG, 2019年04月, 査読有り
      • Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis.
        Chikashi Terao; Hajime Yoshifuji; Takayoshi Matsumura; Taeko K Naruse; Tomonori Ishii; Yoshikazu Nakaoka; Yohei Kirino; Keitaro Matsuo; Tomoki Origuchi; Masakazu Shimizu; Yasuhiro Maejima; Eisuke Amiya; Natsuko Tamura; Takahisa Kawaguchi; Meiko Takahashi; Kazuya Setoh; Koichiro Ohmura; Ryu Watanabe; Tetsuya Horita; Tatsuya Atsumi; Mitsuru Matsukura; Tetsuro Miyata; Yuta Kochi; Toshio Suda; Kazuo Tanemoto; Akira Meguro; Yukinori Okada; Akiyoshi Ogimoto; Motohisa Yamamoto; Hiroki Takahashi; Shingo Nakayamada; Kazuyoshi Saito; Masataka Kuwana; Nobuhisa Mizuki; Yasuharu Tabara; Atsuhisa Ueda; Issei Komuro; Akinori Kimura; Mitsuaki Isobe; Tsuneyo Mimori; Fumihiko Matsuda
        Proceedings of the National Academy of Sciences of the United States of America, 2018年12月18日, 査読有り
      • Prediction model for pancreatic cancer risk in the general Japanese population.
        Nakatochi M; Lin Y; Ito H; Hara K; Kinoshita F; Kobayashi Y; Ishii H; Ozaka M; Sasaki T; Sasahira N; Morimoto M; Kobayashi S; Ueno M; Ohkawa S; Egawa N; Kuruma S; Mori M; Nakao H; Wang C; Nishiyama T; Kawaguchi T; Takahashi M; Matsuda F; Kikuchi S; Matsuo K
        PloS one, 2018年, 査読有り
      • Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers
        Takahisa Kawaguchi; Toshihide Shima; Masayuki Mizuno; Yasuhide Mitsumoto; Atsushi Umemura; Yoshihiro Kanbara; Saiyu Tanaka; Yoshio Sumida; Kohichiro Yasui; Meiko Takahashi; Keitaro Matsuo; Yoshito Itoh; Katsutoshi Tokushige; Etsuko Hashimoto; Kendo Kiyosawa; Masanori Kawaguchi; Hiroyuki Itoh; Hirofumi Uto; Yasuji Komorizono; Ken Shirabe; Shiro Takami; Toshinari Takamura; Miwa Kawanaka; Ryo Yamada; Fumihiko Matsuda; Takeshi Okanoue
        PLoS ONE, 2018年01月01日, 査読有り
      • Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
        Chikashi Terao; Takahisa Kawaguchi; Philippe Dieude; John Varga; Masataka Kuwana; Marie Hudson; Yasushi Kawaguchi; Marco Matucci-Cerinic; Koichiro Ohmura; Gabriela Riemekasten; Aya Kawasaki; Paolo Airo; Tetsuya Horita; Akira Oka; Eric Hachulla; Hajime Yoshifuji; Paola Caramaschi; Nicolas Hunzelmann; Murray Baron; Tatsuya Atsumi; Paul Hassoun; Takeshi Torii; Meiko Takahashi; Yasuharu Tabara; Masakazu Shimizu; Akiko Tochimoto; Naho Ayuzawa; Hidetoshi Yanagida; Hiroshi Furukawa; Shigeto Tohma; Minoru Hasegawa; Manabu Fujimoto; Osamu Ishikawa; Toshiyuki Yamamoto; Daisuke Goto; Yoshihide Asano; Masatoshi Jinnin; Hirahito Endo; Hiroki Takahashi; Kazuhiko Takehara; Shinichi Sato; Hironobu Ihn; Soumya Raychaudhuri; Katherine Liao; Peter Gregersen; Naoyuki Tsuchiya; Valeria Riccieri; Inga Melchers; Gabriele Valentini; Anne Cauvet; Maria Martinez; Tsuneyo Mimori; Fumihiko Matsuda; Yannick Allanore
        Annals of the rheumatic diseases, 2017年06月, 査読有り
      • Genotype Analyses in the Japanese and Belarusian Populations Reveal Independent Effects of rs965513 and rs1867277 but Do Not Support the Role of FOXE1 Polyalanine Tract Length in Conferring Risk for Papillary Thyroid Carcinoma
        Alyaksandr V. Nikitski; Tatiana I. Rogounovitch; Andrey Bychkov; Meiko Takahashi; Koh-ichiro Yoshiura; Norisato Mitsutake; Takahisa Kawaguchi; Michiko Matsuse; Valentina M. Drozd; Yuri Demidchik; Eijun Nishihara; Mitsuyoshi Hirokawa; Akira Miyauchi; Alexander V. Rubanovich; Fumihiko Matsuda; Shunichi Yamashita; Vladimir A. Saenko
        THYROID, 2017年02月, 査読有り
      • Relationship Among Chlamydia and Mycoplasma Pneumoniae Seropositivity, IKZF1 Genotype and Chronic Obstructive Pulmonary Disease in A General Japanese Population The Nagahama Study
        Shigeo Muro; Yasuharu Tabara; Hisako Matsumoto; Kazuya Setoh; Takahisa Kawaguchi; Meiko Takahashi; Isao Ito; Yutaka Ito; Kimihiko Murase; Chikashi Terao; Shinji Kosugi; Ryo Yamada; Akihiro Sekine; Takeo Nakayama; Kazuo Chin; Michiaki Mishima; Fumihiko Matsuda
        MEDICINE, 2016年04月, 査読有り
      • Descriptive epidemiology of spot urine sodium-to-potassium ratio clarified close relationship with blood pressure level: the Nagahama study
        Yasuharu Tabara; Yoshimitsu Takahashi; Kyoko Kumagai; Kazuya Setoh; Takahisa Kawaguchi; Meiko Takahashi; Yuki Muraoka; Akitaka Tsujikawa; Norimoto Gotoh; Chikashi Terao; Ryo Yamada; Shinji Kosugi; Akihiro Sekine; Nagahisa Yoshimura; Takeo Nakayama; Fumihiko Matsuda
        JOURNAL OF HYPERTENSION, 2015年12月, 査読有り
      • Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis
        Chikashi Terao; Noriyuki Yamakawa; Koichiro Yano; Iris M. Markusse; Katsunori Ikari; Shinji Yoshida; Moritoshi Furu; Motomu Hashimoto; Hiromu Ito; Takao Fujii; Koichiro Ohmura; Kosaku Murakami; Meiko Takahashi; Masahide Hamaguchi; Yasuharu Tabara; Atsuo Taniguchi; Shigeki Momohara; Soumya Raychaudhuri; Cornelia F. Allaart; Hisashi Yamanaka; Tsuneyo Mimori; Fumihiko Matsuda
        ARTHRITIS & RHEUMATOLOGY, 2015年12月, 査読有り
      • The 8q24 rs6983267G variant is associated with increased thyroid cancer risk
        Ruta Sahasrabudhe; Ana Estrada; Paul Lott; Lynn Martin; Guadalupe Polanco Echeverry; Alejandro Velez; Gila Neta; Meiko Takahasi; Vladimir Saenko; Norisato Mitsutake; Emma Jaeguer; Carlos Simon Duque; Alejandro Rios; Mabel Bohorquez; Rodrigo Prieto; Angel Criollo; Magdalena Echeverry; Ian Tomlinson; Luis G. Carvajal Carmona
        ENDOCRINE-RELATED CANCER, 2015年10月, 査読有り
      • Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels
        Kazuya Setoh; Chikashi Terao; Shigeo Muro; Takahisa Kawaguchi; Yasuharu Tabara; Meiko Takahashi; Takeo Nakayama; Shinji Kosugi; Akihiro Sekine; Ryo Yamada; Michiaki Mishima; Fumihiko Matsuda
        NATURE COMMUNICATIONS, 2015年07月, 査読有り
      • Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study
        Chikashi Terao; Keita Asai; Motomu Hashimoto; Toru Yamazaki; Koichiro Ohmura; Akihiko Yamaguchi; Katsu Takahashi; Noriko Takei; Takanori Ishii; Takahisa Kawaguchi; Yasuharu Tabara; Meiko Takahashi; Takeo Nakayama; Shinji Kosugi; Akihiro Sekine; Takao Fujii; Ryo Yamada; Tsuneyo Mimori; Fumihiko Matsuda; Kazuhisa Bessho
        JOURNAL OF AUTOIMMUNITY, 2015年05月, 査読有り
      • Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population
        Chikashi Terao; Koichiro Ohmura; Yuta Kochi; Katsunori Ikari; Yukinori Okada; Masakazu Shimizu; Naoshi Nishina; Akari Suzuki; Keiko Myouzen; Takahisa Kawaguchi; Meiko Takahashi; Kiyoshi Takasugi; Akira Murasawa; Shinichi Mizuki; Mitsuhiro Iwahashi; Keiko Funahashi; Masamitsu Natsumeda; Moritoshi Furu; Motomu Hashimoto; Hiromu Ito; Takao Fujii; Kazuhiko Ezawa; Tsukasa Matsubara; Tsutomu Takeuchi; Michiaki Kubo; Ryo Yamada; Atsuo Taniguchi; Hisashi Yamanaka; Shigeki Momohara; Kazuhiko Yamamoto; Tsuneyo Mimori; Fumihiko Matsuda
        ARTHRITIS RESEARCH & THERAPY, 2015年04月, 査読有り
      • Takayasu arteritis and ulcerative colitis -high concurrence ratio and genetic overlap.
        Terao C; Matsumura T; Yoshifuji H; Kirino Y; Maejima Y; Nakaoka Y; Takahashi M; Amiya E; Tamura N; Nakajima T; Origuchi T; Horita T; Matsukura M; Kochi Y; Ogimoto A; Yamamoto M; Takahashi H; Nakayamada S; Saito K; Wada Y; Narita I; Kawaguchi Y; Yamanaka H; Ohmura K; Atsumi T; Tanemoto K; Miyata T; Kuwana M; Komuro I; Tabara Y; Ueda A; Isobe M; Mimori T; Matsuda F
        Arthritis & rheumatology (Hoboken, N.J.), 2015年04月, 査読有り
      • The Common Genetic Variant rs944289 on Chromosome 14q13.3 Associates with Risk of Both Malignant and Benign Thyroid Tumors in the Japanese Population
        Tatiana I. Rogounovitch; Andrey Bychkov; Meiko Takahashi; Norisato Mitsutake; Masahiro Nakashima; Alyaksandr V. Nikitski; Tomayoshi Hayashi; Mitsuyoshi Hirokawa; Katsu Ishigaki; Kazuto Shigematsu; Tetiana Bogdanova; Michiko Matsuse; Eijun Nishihara; Shigeki Minami; Kosho Yamanouchi; Masahiro Ito; Takahisa Kawaguchi; Hisayoshi Kondo; Noboru Takamura; Yasuhiro Ito; Akira Miyauchi; Fumihiko Matsuda; Shunichi Yamashita; Vladimir A. Saenko
        THYROID, 2015年03月, 査読有り
      • Lack of association between the BIM deletion polymorphism and the risk of lung cancer with and without EGFR mutations.
        Hiromichi Ebi; Isao Oze; Takayuki Nakagawa; Hidemi Ito; Satoyo Hosono; Fumihiko Matsuda; Meiko Takahashi; Shinji Takeuchi; Yukinori Sakao; Toyoaki Hida; Anthony C Faber; Hideo Tanaka; Yasushi Yatabe; Tetsuya Mitsudomi; Seiji Yano; Keitaro Matsuo
        Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2015年01月, 査読有り
      • Effects of Smoking and Shared Epitope on the Production of Anti-Citrullinated Peptide Antibody in a Japanese Adult Population
        Chikashi Terao; Koichiro Ohmura; Katsunori Ikari; Takahisa Kawaguchi; Meiko Takahashi; Kazuya Setoh; Takeo Nakayama; Shinji Kosugi; Akihiro Sekine; Yasuharu Tabara; Atsuo Taniguchi; Shigeki Momohara; Hisashi Yamanaka; Ryo Yamada; Fumihiko Matsuda; Tsuneyo Mimori
        ARTHRITIS CARE & RESEARCH, 2014年12月, 査読有り
      • Association Between Antinuclear Antibodies and the HLA Class II Locus and Heterogeneous Characteristics of Staining Patterns The Nagahama Study
        Chikashi Terao; Koichiro Ohmura; Ryo Yamada; Takahisa Kawaguchi; Masakazu Shimizu; Yasuharu Tabara; Meiko Takahashi; Kazuya Setoh; Takeo Nakayama; Shinji Kosugi; Akihiro Sekine; Fumihiko Matsuda; Tsuneyo Mimori
        ARTHRITIS & RHEUMATOLOGY, 2014年12月, 査読有り
      • A genome-wide association study of serum levels of prostate-specific antigen in the Japanese population
        Chikashi Terao; Naoki Terada; Keitaro Matsuo; Takahisa Kawaguchi; Koji Yoshimura; Norio Hayashi; Masakazu Shimizu; Norihito Soga; Meiko Takahashi; Yoshihiko Kotoura; Ryo Yamada; Osamu Ogawa; Fumihiko Matsuda
        JOURNAL OF MEDICAL GENETICS, 2014年08月, 査読有り
      • Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases
        Kosuke Tanaka; Chikashi Terao; Koichiro Ohmura; Meiko Takahashi; Ran Nakashima; Yoshitaka Imura; Hajime Yoshifuji; Naoichiro Yukawa; Takashi Usui; Takao Fujii; Tsuneyo Mimori; Fumihiko Matsuda
        JOURNAL OF HUMAN GENETICS, 2014年02月, 査読有り
      • Genome-Wide Association Study of Genetic Factors Related to Confectionery Intake: Potential Roles of the ADIPOQ Gene
        Kenji Wakai; Keitaro Matsuo; Fumihiko Matsuda; Ryo Yamada; Meiko Takahashi; Takahisa Kawaguchi; Yasushi Yatabe; Hidemi Ito; Satoyo Hosono; Kazuo Tajima; Mariko Naito; Emi Morita; Guang Yin; Tatsuhiko Sakamoto; Naoyuki Takashima; Sadao Suzuki; Noriko Nakahata; Haruo Mikami; Keizo Ohnaka; Yoshiyuki Watanabe; Kokichi Arisawa; Michiaki Kubo; Nobuyuki Hamajima; Hideo Tanaka
        OBESITY, 2013年11月, 査読有り
      • Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population
        Chikashi Terao; Hajime Yoshifuji; Akinori Kimura; Takayoshi Matsumura; Koichiro Ohmura; Meiko Takahashi; Masakazu Shimizu; Takahisa Kawaguchi; Zhiyong Chen; Taeko K. Naruse; Aiko Sato-Otsubo; Yusuke Ebana; Yasuhiro Maejima; Hideyuki Kinoshita; Kosaku Murakami; Daisuke Kawabata; Yoko Wada; Ichiei Narita; Junichi Tazaki; Yasushi Kawaguchi; Hisashi Yamanaka; Kimiko Yurugi; Yasuo Miura; Taira Maekawa; Seishi Ogawa; Issei Komuro; Ryozo Nagai; Ryo Yamada; Yasuharu Tabara; Mitsuaki Isobe; Tsuneyo Mimori; Fumihiko Matsuda
        AMERICAN JOURNAL OF HUMAN GENETICS, 2013年08月, 査読有り
      • Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese
        Takahisa Kawaguchi; Yoshio Sumida; Atsushi Umemura; Keitaro Matsuo; Meiko Takahashi; Toshinari Takamura; Kohichiroh Yasui; Toshiji Saibara; Etsuko Hashimoto; Miwa Kawanaka; Sumio Watanabe; Sumio Kawata; Yasuharu Imai; Miki Kokubo; Toshihide Shima; Hyohun Park; Hideo Tanaka; Kazuo Tajima; Ryo Yamada; Fumihiko Matsuda; Takeshi Okanoue
        PLOS ONE, 2012年06月, 査読有り
      • Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
        Yukinori Okada; Chikashi Terao; Katsunori Ikari; Yuta Kochi; Koichiro Ohmura; Akari Suzuki; Takahisa Kawaguchi; Eli A. Stahl; Fina A. S. Kurreeman; Nao Nishida; Hiroko Ohmiya; Keiko Myouzen; Meiko Takahashi; Tetsuji Sawada; Yuichi Nishioka; Masao Yukioka; Tsukasa Matsubara; Shigeyuki Wakitani; Ryota Teshima; Shigeto Tohma; Kiyoshi Takasugi; Kota Shimada; Akira Murasawa; Shigeru Honjo; Keitaro Matsuo; Hideo Tanaka; Kazuo Tajima; Taku Suzuki; Takuji Iwamoto; Yoshiya Kawamura; Hisashi Tanii; Yuji Okazaki; Tsukasa Sasaki; Peter K. Gregersen; Leonid Padyukov; Jane Worthington; Katherine A. Siminovitch; Mark Lathrop; Atsuo Taniguchi; Atsushi Takahashi; Katsushi Tokunaga; Michiaki Kubo; Yusuke Nakamura; Naoyuki Kamatani; Tsuneyo Mimori; Robert M. Plenge; Hisashi Yamanaka; Shigeki Momohara; Ryo Yamada; Fumihiko Matsuda; Kazuhiko Yamamoto
        NATURE GENETICS, 2012年05月, 査読有り
      • Genome-wide association study of the genetic factors related to confectionery intake: potential roles of the ADIPOQ gene
        Wakai,K; Matsuo,K; Matsuda,F; Yamada,R; Takahashi,M
        Obesity (Silver Spring). doi: 10.1002, 2012年02月14日, 査読有り
      • A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations
        Roubila Meziani; Ryo Yamada; Meiko Takahashi; Kenei Ohigashi; Akio Morinobu; Chikashi Terao; Hitomi Hiratani; Koichiro Ohmura; Masao Yamaguchi; Takashi Nomura; Alexandre Vasilescu; Miki Kokubo; Victor Renault; Katsura Hirosawa; Chanavee Ratanajaraya; Simon Heath; Tsuneyo Mimori; Shimon Sakaguchi; Mark Lathrop; Inga Melchers; Shunichi Kumagai; Fumihiko Matsuda
        MODERN RHEUMATOLOGY, 2012年02月, 査読有り
      • Transcriptional factor Prox1 plays an essential role in the antiproliferative action of interferon-γ in esophageal cancer cells.
        Akagami M; Kawada K; Kubo H; Kawada M; Takahashi M; Kaganoi J; Kato S; Itami A; Shimada Y; Watanabe G; Sakai Y
        Annals of surgical oncology, 2011年12月, 査読有り
      • The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population
        Michiko Matsuse; Meiko Takahashi; Norisato Mitsutake; Eijun Nishihara; Mitsuyoshi Hirokawa; Takahisa Kawaguchi; Tatiana Rogounovitch; Vladimir Saenko; Andrey Bychkov; Keiji Suzuki; Keitaro Matsuo; Kazuo Tajima; Akira Miyauchi; Ryo Yamada; Fumihiko Matsuda; Shunichi Yamashita
        JOURNAL OF MEDICAL GENETICS, 2011年09月, 査読有り
      • The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population
        Michiko Matsuse; Meiko Takahashi; Norisato Mitsutake; Eijun Nishihara; Mitsuyoshi Hirokawa; Takahisa Kawaguchi; Tatiana Rogounovitch; Vladimir Saenko; Andrey Bychkov; Keiji Suzuki; Keitaro Matsuo; Kazuo Tajima; Akira Miyauchi; Ryo Yamada; Fumihiko Matsuda; Shunichi Yamashita
        JOURNAL OF MEDICAL GENETICS, 2011年09月, 査読有り
      • A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males
        Chanavee Ratanajaraya; Hiroyuki Nishiyama; Meiko Takahashi; Takahisa Kawaguchi; Ryoichi Saito; Yoshiki Mikami; Mikita Suyama; Mark Lathrop; Ryo Yamada; Osamu Ogawa; Fumihiko Matsuda
        JOURNAL OF HUMAN GENETICS, 2011年08月, 査読有り
      • The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population
        Chikashi Terao; Ryo Yamada; Koichiro Ohmura; Meiko Takahashi; Takahisa Kawaguchi; Yuta Kochi; Yukinori Okada; Yusuke Nakamura; Kazuhiko Yamamoto; Inga Melchers; Mark Lathrop; Tsuneyo Mimori; Fumihiko Matsuda
        HUMAN MOLECULAR GENETICS, 2011年07月, 査読有り
      • Myelin Basic Protein as a Novel Genetic Risk Factor in Rheumatoid Arthritis-A Genome-Wide Study Combined with Immunological Analyses
        Chikashi Terao; Koichiro Ohmura; Masaki Katayama; Meiko Takahashi; Miki Kokubo; Gora Diop; Yoshinobu Toda; Natsuki Yamamoto; Reiko Shinkura; Masakazu Shimizu; Ivo Gut; Simon Heath; Inga Melchers; Toshiaki Manabe; Mark Lathrop; Tsuneyo Mimori; Ryo Yamada; Fumihiko Matsuda
        PLOS ONE, 2011年06月, 査読有り
      • A Trans-ethnic genetic study of Rheumatoid Arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations. Mod Rheumatol. 2011 May 24.
        Meziani, R; Yamada, R; Takahashi, M; Ohigashi, K
        2011年, 査読有り
      • The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population. Hum Mol Genet. 2011 Jul 1;20(13):2680-5.
        Terao, C; Yamada, R; Ohmura, K; Takahashi, M
        2011年, 査読有り
      • The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl
        Meiko Takahashi; Vladimir A. Saenko; Tatiana I. Rogounovitch; Takahisa Kawaguchi; Valentina M. Drozd; Hisako Takigawa-Imamura; Natallia M. Akulevich; Chanavee Ratanajaraya; Norisato Mitsutake; Noboru Takamura; Larisa I. Danilova; Maxim L. Lushchik; Yuri E. Demidchik; Simon Heath; Ryo Yamada; Mark Lathrop; Fumihiko Matsuda; Shunichi Yamashita
        HUMAN MOLECULAR GENETICS, 2010年06月, 査読有り
      • Immunohistochemical detection of the lymphatic marker podoplanin in diverse types of human cancer cells using a novel antibody
        Tomoya Kono; Masayuki Shimoda; Meiko Takahashi; Kyoichi Matsumoto; Takanobu Yoshimoto; Mika Mizutani; Chiharu Tabata; Kae Okoshi; Hiromi Wada; Hajime Kubo
        INTERNATIONAL JOURNAL OF ONCOLOGY, 2007年09月, 査読有り
      • RNA mutations of prox1 detected in human esophageal cancer cells by the shifted termination assay
        Takanobu Yoshimoto; Meiko Takahashi; Satoshi Nagayama; Go Watanabe; Yutaka Shimada; Yoshiharu Sakasi; Hailme Kubo
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007年07月, 査読有り
      • Thalidomide prevents bleomycin-induced pulmonary fibrosis in mice
        Chiharu Tabata; Rie Tabata; Yoshio Kadokawa; Shigeo Hisamori; Meiko Takahashi; Michiaki Mishima; Takashi Nakano; Hajime Kubo
        JOURNAL OF IMMUNOLOGY, 2007年07月, 査読有り
      • Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cells
        Meiko Takahashi; Takanobu Yoshimoto; Masayuki Shimoda; Tomoya Kono; Masayuki Koizumi; Shujiro Yazumi; Yutaka Shimada; Ryuichiro Doi; Tsutomu Chiba; Hajime Kubo
        NEOPLASIA, 2006年12月, 査読有り
      • All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis
        Chiharu Tabata; Yoshio Kadokawa; Rie Tabata; Meiko Takahashi; Kae Okoshi; Yoshiharu Sakai; Michiaki Mishima; Hajime Kubo
        AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006年12月, 査読有り
      • A homeobox protein, Prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma
        Masayuki Shimoda; Meiko Takahashi; Takanobu Yoshimoto; Tomoya Kono; Iwao Ikai; Hajime Kubo
        CLINICAL CANCER RESEARCH, 2006年10月, 査読有り
      • Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells.
        Tomoya Kono; Hajime Kubo; Chikashi Shimazu; Yoshihide Ueda; Meiko Takahashi; Kentoku Yanagi; Naoya Fujita; Takashi Tsuruo; Hiromi Wada; Jun K Yamashita
        Arteriosclerosis, thrombosis, and vascular biology, 2006年09月, 査読有り
      • Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer
        M Takahashi; Y Nakamura; K Obama; Y Furukawa
        INTERNATIONAL JOURNAL OF ONCOLOGY, 2005年12月, 査読有り
      • Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer
        M Takahashi; YM Lin; Y Nakamura; Y Furukawa
        ONCOGENE, 2004年12月, 査読有り
      • Molecular mechanisms of lymphangiogenesis
        M Takahashi; T Yoshimoto; H Kubo
        INTERNATIONAL JOURNAL OF HEMATOLOGY, 2004年07月, 査読有り
      • Two cases of the caudal duplication anomaly including a discordant monozygotic twin
        HY Kroes; M Takahashi; RJ Zijlstra; JALL Baert; KA Kooi; RMW Hofstra; AJ van Essen
        AMERICAN JOURNAL OF MEDICAL GENETICS, 2002年11月, 査読有り
      • Isolation of a novel human gene, APCDD1, as a direct target of the beta-catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis
        M Takahashi; M Fujita; Y Furukawa; R Hamamoto; T Shimokawa; N Miwa; M Ogawa; Y Nakamura
        CANCER RESEARCH, 2002年10月, 査読有り
      • Isolation of a novel human gene, APCDD1, as a direct target of the beta-catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis
        M Takahashi; M Fujita; Y Furukawa; R Hamamoto; T Shimokawa; N Miwa; M Ogawa; Y Nakamura
        CANCER RESEARCH, 2002年10月, 査読有り
      • Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers
        M Takahashi; T Tsunoda; M Seiki; Y Nakamura; Y Furukawa
        ONCOGENE, 2002年08月, 査読有り
      • Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours
        N Leonard; R Chaggar; C Jones; M Takahashi; A Nikitopoulou; Lakhani, SR
        JOURNAL OF CLINICAL PATHOLOGY, 2001年09月, 査読有り
      • Isolation of a novel human gene, ARHGAP9, encoding a Rho-GTPase activating protein
        Y Furukawa; T Kawasoe; Y Daigo; T Nishiwaki; H Ishiguro; M Takahashi; J Kitayama; Y Nakamura
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001年06月, 査読有り
      • Identification of the familial cylindromatosis tumour suppressor gene
        Bignell, G.R; Warren, W; Seal, S; Takahashi, M; Rapley E; Barfoot, R; Gree, H; Brown, C; Biggs, P.J; Lakhani, S.R; Jones, C; Hansen, J; Blair, E; Hofmann, B; Siebert, R; Turner, G; Evans, G; Schrander-Stumpel, C; Beemer, F.A; van den Ouweland, A; Halley, D; Delpech, B; Cleveland, M.G; Leigh, I; Leisti, J; Rasmussen, S; Wallace, M.R; Fenske, C; Banerjee, P; Oiso, N; Chaggar, R; Merrett, S; Leonard, N; Huber, M; Hohl, D; Chapman, P; Burn, J; Swift, S; Smith, A; Ashworth, A; Stratton, M.R
        Nature Genet, 2000年06月, 査読有り
      • Linkage and LOH studies in 19 cylindromatosis families show no evidence of genetic heterogeneity and refine the CYLD locus on chromosome 16q12-q13
        M Takahashi; E Rapley; PJ Biggs; Lakhani, SR; D Cooke; J Hansen; E Blair; B Hofmann; R Siebert; G Turner; DG Evans; C Schrander-Stumpel; FA Beemer; WA van Vloten; MH Breuning; A van den Ouweland; D Halley; B Delpech; M Cleveland; Leigh, I; P Chapman; J Burn; D Hohl; JP Gorog; S Seal; J Mangion; W Warren; G Bignell; MR Stratton
        HUMAN GENETICS, 2000年01月, 査読有り

      外部資金:科学研究費補助金

      外部資金:その他

      • チェルノブイリコホートの全ゲノム解析による放射線誘発甲状腺がん感受性遺伝子の同定
        財団法人藤原記念財団奨励金
        自 2010年, 至 2011年
        高橋めい子
      list
        Last Updated :2022/05/14

        教育

        担当科目

        • 自 2015年04月, 至 2016年03月
          ゲノムコホート研究(LIMS)
          前期集中, 医学研究科
        • 自 2016年04月, 至 2017年03月
          ゲノムコホート研究(LIMS)
          前期集中, 医学研究科
        • 自 2017年04月, 至 2018年03月
          ゲノムコホート研究
          前期, 工学研究科
        • 自 2017年04月, 至 2018年03月
          ゲノムコホート研究(LIMS)
          前期集中, 医学研究科
        • 自 2018年04月, 至 2019年03月
          ゲノムコホート研究
          前期, 工学研究科
        • 自 2018年04月, 至 2019年03月
          ゲノムコホート研究(LIMS)
          前期集中, 医学研究科
        • 自 2019年04月, 至 2020年03月
          ゲノムコホート研究(LIMS)
          前期集中, 医学研究科

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