基本情報

学位

• 理学修士(北海道大学)
• 博士（理学）(北海道大学)

使用言語

• 英語

ID,URL

• J-Global ID

  201601013187777010

researchmap URL

• https://researchmap.jp/7000015430

研究

研究テーマ・研究概要

• 研究テーマ

  神経変性疾患の新規治療法の開発

• 研究概要

  神経変性疾患をターゲットとした創薬開発

研究分野

• その他, その他

論文

• A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy.

  Masanori Sawamura; Kiyoshi Tachikawa; Rie Hikawa; Hisako Akiyama; Seiji Kaji; Ken Yasuda; Angel I Leu; Hyojung Hong; Rajesh Mukthavaram; Pad Chivukula; Hodaka Yamakado; Yoshio Hirabayashi; Ryosuke Takahashi; Shu-Ichi Matsuzawa

  Molecular therapy. Nucleic acids, 2024年12月10日

  この論文にアクセスする：

  
• NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration.

  Tomonori Hoshino; Atsushi Mukai; Hirofumi Yamashita; Hidemi Misawa; Makoto Urushitani; Yoshitaka Tashiro; Shu-Ichi Matsuzawa; Ryosuke Takahashi

  Molecular brain, 2024年10月23日

  この論文にアクセスする：

  
• A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

  Tomoyuki Ishimoto; Miki Oono; Seiji Kaji; Takashi Ayaki; Katsuya Nishida; Itaru Funakawa; Takakuni Maki; Shu-ichi Matsuzawa; Ryosuke Takahashi; Hodaka Yamakado

  Molecular Brain, 2024年05月24日

  
• パーキンソン病モデルにおいてαシヌクレイン線維の構造が伝播活性に与える影響

  大平 純一朗; 澤村 正典; 田口 智之; 石本 智之; 上田 潤; 生野 真嗣; 松澤 秀一; 高橋 良輔; 山門 穂高

  神経治療学, 2023年10月

  
• 多系統萎縮症(MSA)におけるグリア細胞質内封入体(GCI)形成過程の評価に有用な新規トランスジェニックマウスの作製

  石本 智之; 大野 美樹; 梶 誠兒; 綾木 孝; 西田 勝也; 舟川 格; 眞木 崇州; 松澤 秀一; 高橋 良輔; 山門 穂高

  日本自律神経学会総会プログラム・抄録集, 2023年10月

  
• 多系統萎縮症におけるグリア細胞質内封入体形成過程の解明に有用な新規トランスジェニックマウスの作製

  石本 智之; 大野 美樹; 梶 誠兒; 綾木 孝; 西田 勝也; 舟川 格; 眞木 崇州; 松澤 秀一; 高橋 良輔; 山門 穂高

  神経治療学, 2023年10月

  
• 多系統萎縮症におけるグリア細胞質内封入体形成過程の解明に有用な新規トランスジェニックマウスの作製

  石本 智之; 大野 美樹; 梶 誠兒; 綾木 孝; 西田 勝也; 舟川 格; 眞木 崇州; 松澤 秀一; 高橋 良輔; 山門 穂高

  日本神経精神薬理学会年会プログラム・抄録集, 2023年09月

  
• 多系統萎縮症におけるグリア細胞質内封入体形成過程の解明に有用な新規トランスジェニックマウスの作製

  石本 智之; 大野 美樹; 梶 誠兒; 綾木 孝; 西田 勝也; 舟川 格; 眞木 崇州; 松澤 秀一; 高橋 良輔; 山門 穂高

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 2023年07月

  
• MSAにおけるα-シヌクレイン凝集機序を解析するための新規モデルマウスの確立(The novel mice model to investigate the mechanisms of alpha synuclein aggregation in MSA)

  石本 智之; 山門 穂高; 大野 美樹; 梶 誠兒; 綾木 孝; 眞木 崇州; 松澤 秀一; 高橋 良輔

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 2021年07月

  
• 多系統萎縮症におけるグリア細胞質内封入体形成過程の解明に有用な新規トランスジェニックマウスの作製

  石本 智之; 大野 美樹; 梶 誠兒; 綾木 孝; 西田 勝也; 舟川 格; 眞木 崇州; 松澤 秀一; 高橋 良輔; 山門 穂高

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 2023年07月

  
• 多系統萎縮症におけるグリア細胞質内封入体形成過程の評価に有用な新規モデルマウスの作製

  石本 智之; 山門 穂高; 大野 美樹; 梶 誠兒; 綾木 孝; 眞木 崇州; 松澤 秀一; 高橋 良輔

  日本自律神経学会総会プログラム・抄録集, 2022年10月

  
• 多系統萎縮症におけるグリア細胞質内封入体形成メカニズムの解明に有用な新規モデルマウスの作製

  石本 智之; 山門 穂高; 大野 美樹; 梶 誠兒; 綾木 孝; 眞木 崇州; 松澤 秀一; 高橋 良輔

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 2022年07月

  
• Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission.

  Jun Ueda; Norihito Uemura; Tomoyuki Ishimoto; Tomoyuki Taguchi; Masanori Sawamura; Etsuro Nakanishi; Masashi Ikuno; Shuichi Matsuzawa; Hodaka Yamakado; Ryosuke Takahashi

  Movement disorders : official journal of the Movement Disorder Society, 2023年04月17日

  この論文にアクセスする：

  
• p53 Suppresses the c-Myb-induced activation of heat shock transcription factor 3

  Jun Tanikawa; Emi Ichikawa-Iwata; Chie Kanei-Ishii; Akira Nakai; Shu-Ichi Matsuzawa; John C. Reed; Shunsuke Ishii

  Journal of Biological Chemistry, 2000年05月19日, 査読有り

  
• Mitochondrial dysfunction in a mouse model of prodromal Parkinson's disease: A metabolomic analysis.

  Masashi Ikuno; Hodaka Yamakado; Ikuko Amano; Yusuke Hatanaka; Norihito Uemura; Shu-Ichi Matsuzawa; Ryosuke Takahashi

  Neuroscience letters, 2021年09月24日

  
• The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy.

  Yutaka Inoue; Takashi Ayaki; Tomoyuki Ishimoto; Hodaka Yamakado; Takakuni Maki; Shuichi Matsuzawa; Nobukatsu Sawamoto; Ryosuke Takahashi

  Neuroscience letters, 2021年05月24日

  
• Impact of Gba2 on neuronopathic Gaucher's disease and α-synuclein accumulation in medaka (Oryzias latipes).

  Etsuro Nakanishi; Norihito Uemura; Hisako Akiyama; Masato Kinoshita; Sawamura Masanori; Yosuke Taruno; Hodaka Yamakado; Shu-Ichi Matsuzawa; Shunichi Takeda; Yoshio Hirabayashi; Ryosuke Takahashi

  Molecular brain, 2021年05月10日

  この論文にアクセスする：

  
• Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models.

  Jun Ueda; Norihito Uemura; Masanori Sawamura; Tomoyuki Taguchi; Masashi Ikuno; Seiji Kaji; Yosuke Taruno; Shuichi Matsuzawa; Hodaka Yamakado; Ryosuke Takahashi

  Movement disorders : official journal of the Movement Disorder Society, 2021年04月04日

  この論文にアクセスする：

  
• 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis.

  Tomonori Hoshino; Shu-Ichi Matsuzawa; Ryosuke Takahashi

  Neuroscience research, 2021年02月

  
• Susceptibility to erastin-induced ferroptosis decreases during maturation in a human oligodendrocyte cell line.

  Tomonori Hoshino; Hodaka Yamakado; Ryosuke Takahashi; Shu-Ichi Matsuzawa

  FEBS open bio, 2020年09月

  
• SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.

  Jiang TX; Zou JB; Zhu QQ; Liu CH; Wang GF; Du TT; Luo ZY; Guo F; Zhou LM; Liu JJ; Zhang W; Shu YS; Yu L, Li P; Ronai ZA; Matsuzawa S; Goldberg AL; Qiu XB

  Proceedings of the National Academy of Sciences of the United States of America, 2019年06月, 査読有り

  
• Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity

  Marisa Sanchez; Zebin Xia; Elizabeth Rico-Bautista; Xihua Cao; Michael Cuddy; David J. Castro; Ricardo G. Correa; Liqun Chen; Jinghua Yu; Andrey Bobkov; Vivian Ruvolo; Michael Andreeff; Robert G. Oshima; Shu-Ichi Matsuzawa; John C. Reed; Xiao-Kun Zhang; Donna Hansel; Dieter A. Wolf; Marcia I. Dawson

  Oncotarget, 2018年05月18日, 査読有り

  
• Melanoma antigen A12 regulates cell cycle via tumor suppressor p21 expression

  Teruki Yanagi; Ko Nagai; Hiroshi Shimizu; Shu-Ichi Matsuzawa

  ONCOTARGET, 2017年09月, 査読有り

  
• Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity

  Erina Joo; Toru Fukushima; Norio Harada; John C. Reed; Shu-ichi Matsuzawa; Nobuya Inagaki

  SCIENTIFIC REPORTS, 2016年10月, 査読有り

  この論文にアクセスする：

  
• Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

  Kate Welsh; Snezana Milutinovic; Robert J. Ardecky; Marcos Gonzalez-Lopez; Santhi Reddy Ganji; Peter Teriete; Darren Finlay; Stefan Riedl; Shu-ichi Matsuzawa; Clemencia Pinilla; Richard Houghten; Kristiina Vuori; John C. Reed; Nicholas D. P. Cosford

  PLOS ONE, 2016年09月, 査読有り

  
• Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins

  Paulo H. C. Godoi; Rachel P. Wilkie-Grantham; Asami Hishiki; Renata Sano; Yasuko Matsuzawa; Hiroko Yanagi; Claudia E. Munte; Ya Chen; Yong Yao; Francesca M. Marassi; Hans R. Kalbitzer; Shu-ichi Matsuzawa; John C. Reed

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2016年07月, 査読有り

  
• Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth

  Teruki Yanagi; Kiyoshi Tachikawa; Rachel Wilkie-Grantham; Asami Hishiki; Ko Nagai; Ellen Toyonaga; Pad Chivukula; Shu-ichi Matsuzawa

  MOLECULAR THERAPY-NUCLEIC ACIDS, 2016年06月, 査読有り

  この論文にアクセスする：

  
• Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML)

  Snezana Milutinovic; Susanne Heynen-Genel; Elizabeth Chao; Antimone Dewing; Ricardo Solano; Loribelle Milan; Nikki Barron; Min He; Paul W. Diaz; Shuichi Matsuzawa; John C. Reed; Christian A. Hassig

  PLOS ONE, 2016年03月, 査読有り

  
• Dual Agonist Surrobody Simultaneously Activates Death Receptors DR4 and DR5 to Induce Cancer Cell Death

  Snezana Milutinovic; Arun K. Kashyap; Teruki Yanagi; Carina Wimer; Sihong Zhou; Ryann O'Neil; Aaron L. Kurtzman; Alexsandr Faynboym; Li Xu; Charles H. Hannum; Paul W. Diaz; Shu-ichi Matsuzawa; Michael Horowitz; Lawrence Horowitz; Ramesh R. Bhatt; John C. Reed

  MOLECULAR CANCER THERAPEUTICS, 2016年01月, 査読有り

  
• Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1

  Juan Rong; Ian Pass; Paul W. Diaz; Tram A. Ngo; Michelle Sauer; Gavin Magnuson; Fu-Yue Zeng; Christian A. Hassig; Michael R. Jackson; Nicholas D. P. Cosford; Shu-ichi Matsuzawa; John C. Reed

  JOURNAL OF BIOMOLECULAR SCREENING, 2015年12月, 査読有り

  
• ATG4B (Autophagin-1) Phosphorylation Modulates Autophagy

  Zhifen Yang; Rachel P. Wilkie-Grantham; Teruki Yanagi; Chih-Wen Shu; Shu-ichi Matsuzawa; John C. Reed

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2015年10月, 査読有り

  
• Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress

  Andrea D'Osualdo; Veronica G. Anania; Kebing Yu; Jennie R. Lill; Randal J. Kaufman; Shu-Ichi Matsuzawa; John C. Reed

  PLOS ONE, 2015年06月, 査読有り

  
• A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

  Shuxi Qiao; Michael Dennis; Xiufeng Song; Douangsone D. Vadysirisack; Devika Salunke; Zachary Nash; Zhifen Yang; Marc Liesa; Jun Yoshioka; Shu-Ichi Matsuzawa; Orian S. Shirihai; Richard T. Lee; John C. Reed; Leif W. Ellisen

  NATURE COMMUNICATIONS, 2015年04月, 査読有り

  
• PCTAIRE1-Knockdown Sensitizes Cancer Cells to TNF Family Cytokines

  Teruki Yanagi; Ranxin Shi; Pedro Aza-Blanc; John C. Reed; Shu-ichi Matsuzawa

  PLOS ONE, 2015年03月, 査読有り

  
• PCTAIRE1/PCTK1/CDK16: a new oncotarget?

  Teruki Yanagi; Shu-ichi Matsuzawa

  CELL CYCLE, 2015年02月, 査読有り

  
• PCTAIRE1 Phosphorylates p27 and Regulates Mitosis in Cancer Cells

  Teruki Yanagi; Maryla Krajewska; Shu-ichi Matsuzawa; John C. Reed

  CANCER RESEARCH, 2014年10月, 査読有り

  
• PCTAIRE1 regulates p27 stability, apoptosis and tumor growth in malignant melanoma.

  Yanagi T; Reed JC; Matsuzawa S

  Oncoscience, 2014年, 査読有り

  
• Novel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP protein.

  Wilkie-Grantham RP; Matsuzawa S; Reed JC

  The Journal of biological chemistry, 2013年05月, 査読有り

  
• Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

  Motti Gerlic; Benjamin Faustin; Antonio Postigo; Eric Chi-Wang Yu; Martina Proell; Naran Gombosuren; Maryla Krajewska; Rachel Flynn; Michael Croft; Michael Way; Arnold Satterthwait; Robert C. Liddington; Shahram Salek-Ardakani; Shu-ichi Matsuzawa; John C. Reed

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013年05月, 査読有り

  
• Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling

  Samir Benosman; Palaniyandi Ravanan; Ricardo G. Correa; Ying-Chen Hou; Minjia Yu; Muhammet Fatih Gulen; Xiaoxia Li; James Thomas; Michael Cuddy; Yasuko Matsuzawa; Renata Sano; Paul Diaz; Shu-ichi Matsuzawa; John C. Reed

  PLOS ONE, 2013年05月, 査読有り

  
• Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy.

  Sano R; Hou YC; Hedvat M; Correa RG; Shu CW; Krajewska M; Diaz PW; Tamble CM; Quarato G; Gottlieb RA; Yamaguchi M; Nizet V; Dahl R; Thomas DD; Tait SW; Green DR; Fisher PB; Matsuzawa S; Reed JC

  Genes & development, 2012年05月, 査読有り

  
• TR-FRET-Based High-Throughput Screening Assay for Identification of UBC13 Inhibitors

  Charitha Madiraju; Kate Welsh; Michael P. Cuddy; Paulo H. Godoi; Ian Pass; Tram Ngo; Stefan Vasile; Eduard A. Sergienko; Paul Diaz; Shu-Ichi Matsuzawa; John C. Reed

  JOURNAL OF BIOMOLECULAR SCREENING, 2012年02月, 査読有り

  
• Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines

  Palaniyandi Ravanan; Renata Sano; Priti Talwar; Satoshi Ogasawara; Shu-ichi Matsuzawa; Michael Cuddy; Sanjay K. Singh; G. S. R. Subba Rao; Paturu Kondaiah; John C. Reed

  MOLECULAR CANCER THERAPEUTICS, 2011年09月, 査読有り

  
• Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress

  Yoshito Nagano; Toru Fukushima; Kazuo Okemoto; Keiichiro Tanaka; David D. L. Bowtell; Ze'ev A. Ronai; John C. Reed; Shu-ichi Matsuzawa

  CELL CYCLE, 2011年08月, 査読有り

  
• A High-Content Screening (HCS) Assay for the Identification of Chemical Inducers of PML Oncogenic Domains (PODs)

  Kenneth W. Yip; Michael Cuddy; Clemencia Pinila; Marc Giulanotti; Susanne Heynen-Genel; Shu-Ichi Matsuzawa; John C. Reed

  JOURNAL OF BIOMOLECULAR SCREENING, 2011年02月, 査読有り

  
• Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

  Sean M. Gregory; Beckley K. Davis; John A. West; Debra J. Taxman; Shu-ichi Matsuzawa; John C. Reed; Jenny P. Y. Ting; Blossom Damania

  SCIENCE, 2011年01月, 査読有り

  
• Selective UBC 13 Inhibitors

  Ardecky R; Madiraj C; Matsuzawa S; Zou J; Ganji S; Pass I; Ngo TA; Pinkerton AB; Sergienko E; Su Y; Stonich D; Mangravita-Novo A; Vicchiarelli M; McAnally D; Smith LH; Diwan J; Chung TDY; Matsuzawa Y; Wimer C; Diaz PW; Reed JC

  2010年, 査読有り

  
• KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases

  Yolanda Bayon; Antonio G. Trinidad; Maria L. de la Puerta; Maria del Carmen Rodriguez; Jori Bogetz; Ana Rojas; Jose M. De Pereda; Souad Rahmouni; Scott Williams; Shu-ichi Matsuzawa; John C. Reed; Mariano Sanchez Crespo; Tomas Mustelin; Andres Alolnso

  FEBS JOURNAL, 2008年08月, 査読有り

  
• BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis

  Georg Gdynia; Judith Lehmann-Koch; Sebastian Sieber; Katrin E. Tagscherer; Anne Fassl; Hanswalter Zentgraf; Shu-Ichi Matsuzawa; John C. Reed; Wilfried Roth

  APOPTOSIS, 2008年03月, 査読有り

  
• Impairment of the ubiquitin-proteasome system by cellular FLIP

  Toshiyasu Ishioka; Ryohei Katayama; Ryo Kikuchi; Michie Nishimoto; Shinji Takada; Ritsuko Takada; Shu-ichi Matsuzawa; John C. Reed; Takashi Tsuruo; Mikihiko Naito

  GENES TO CELLS, 2007年06月, 査読有り

  
• Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses

  Toru Fukushima; Shu-ichi Matsuzawa; Christina L. Kress; Jean Marie Bruey; Maryla Krajewska; Sophie Lefebvre; Juan M. Zapata; Ze'ev Ronai; John C. Reed

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007年04月, 査読有り

  
• Bcl-2 and Bcl-X-L regulate proinf lammatory caspase-1 activation by interaction with NALP1

  Jean-Marie Bruey; Nathalie Bruey-Sedano; Frederic Luciano; Dayong Zhai; Ruchi Balpai; Chunyan Xu; Christina L. Kress; Beatrice Bailly-Maitre; Xiaoqing Li; Andrei Osterman; Shu-ichi Matsuzawa; Alexey V. Terskikh; Benjamin Faustin; John C. Reed

  CELL, 2007年04月, 査読有り

  
• Yeast and mammalian two-hybrid systems for studying protein-protein interactions.

  Matsuzawa S; Reed JC

  Methods in molecular biology (Clifton, N.J.), 2007年, 査読有り

  
• HBXIP, cellular target of hepatitis B virus oncoprotein, is a regulator of centrosome dynamics and cytokinesis

  Ryoji Fujii; Changjun Zhu; Yunfei Wen; Hiroyuki Marusawa; Beatrice Bailly-Maitre; Shu-ichi Matsuzawa; Hong Zhang; Youngsoo Kim; C. Frank Bennett; Wei Jiang; John C. Reed

  CANCER RESEARCH, 2006年09月, 査読有り

  
• Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint

  T Fukushima; JM Zapata; NC Singha; M Thomas; CL Kress; M Krajewska; S Krajewski; Z Ronai; JC Reed; S Matsuzawa

  IMMUNITY, 2006年01月, 査読有り

  
• Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex

  E Santelli; M Leone; CL Li; T Fukushima; NE Preece; AJ Olson; KR Ely; JC Reed; M Pellecchia; RC Liddington; S Matsuzawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2005年10月, 査読有り

  
• Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway

  S Matsuzawa; M Cuddy; T Fukushima; JC Reed

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005年10月, 査読有り

  
• Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers

  M Krajewska; H Kim; C Kim; HY Kang; K Welsh; S Matsuzawa; M Tsukamoto; RG Thomas; N Assa-Munt; Z Piao; K Suzuki; M Perucho; S Krajewski; JC Reed

  CLINICAL CANCER RESEARCH, 2005年08月, 査読有り

  
• Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling

  M Naito; R Katayama; T Ishioka; A Suga; K Takubo; M Nanjo; C Hashimoto; M Taira; S Takada; R Takada; M Kitagawa; S Matsuzawa; JC Reed; T Tsuruo

  MOLECULAR AND CELLULAR BIOLOGY, 2004年10月, 査読有り

  
• Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates beta-catenin activity in a p53-dependent manner

  A Iwai; H Marusawa; S Matsuzawa; T Fukushima; M Hijikata; JC Reed; K Shimotohno; T Chiba

  ONCOGENE, 2004年09月, 査読有り

  
• An IAP-IAP complex inhibits apoptosis

  T Dohi; K Okada; F Xia; CE Wilford; T Samuel; K Welsh; H Marusawa; H Zou; R Armstrong; S Matsuzawa; GS Salvesen; JC Reed; DC Altieri

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2004年08月, 査読有り

  
• The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome

  M Fanelli; A Fantozzi; P De Luca; S Caprodossi; S Matsuzawa; MA Lazar; PG Pelicci; S Minucci

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2004年02月, 査読有り

  
• HBXIP functions as a cofactor of survivin in apoptosis suppression

  H Marusawa; S Matsuzawa; K Welsh; H Zou; R Armstrong; Tamm, I; JC Reed

  EMBO JOURNAL, 2003年06月, 査読有り

  
• Comparative analysis of apoptosis and inflammation genes of mice and humans

  JC Reed; K Doctor; A Rojas; JM Zapata; C Stehlik; L Fiorentino; J Damiano; W Roth; S Matsuzawa; R Newman; S Takayama; H Marusawa; FM Xu; G Salvesen; A Godzik

  GENOME RESEARCH, 2003年06月, 査読有り

  
• Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)

  S Matsuzawa; CL Li; CZ Ni; S Takayama; JC Reed; KR Ely

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2003年01月, 査読有り

  
• Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton

  D Nadano; J Nakayama; S Matsuzawa; TA Sato; T Matsuda; MN Fukuda

  BIOCHEMICAL JOURNAL, 2002年06月, 査読有り

  
• Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.

  Haraguchi M; Torii S; Matsuzawa S; Xie Z; Kitada S; Krajewski S; Yoshida H; Mak TW; Reed JC

  The Journal of experimental medicine, 2000年05月, 査読有り

  
• TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.

  Pathan N; Marusawa H; Krajewska M; Matsuzawa S; Kim H; Okada K; Torii S; Kitada S; Krajewski S; Welsh K; Pio F; Godzik A; Reed JC

  The Journal of biological chemistry, 2001年08月, 査読有り

  
• Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

  S Matsuzawa; JC Reed

  MOLECULAR CELL, 2001年05月, 査読有り

  
• TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis

  E Leo; QL Deveraux; C Buchholtz; K Welsh; S Matsuzawa; HR Stennicke; GS Salvesen; JC Reed

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2001年03月, 査読有り

  
• The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NF kappa B activity

  JM Zapata; S Matsuzawa; A Godzik; E Leo; SA Wasserman; JC Reed

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2000年04月, 査読有り

  
• Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40 mediated induction of NF-kappa B and Jun N-terminal kinase activation

  E Leo; K Welsh; S Matsuzawa; JM Zapata; S Kitada; RS Mitchell; KR Ely; JC Reed

  JOURNAL OF BIOLOGICAL CHEMISTRY, 1999年08月, 査読有り

  
• p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1

  S Matsuzawa; S Takayama; BA Froesch; JM Zapata; JC Reed

  EMBO JOURNAL, 1998年05月, 査読有り

  
• BAG-1 modulates the chaperone activity of Hsp70/Hsc70

  S Takayama; DN Bimston; S Matsuzawa; BC Freeman; C AimeSempe; ZH Xie; RI Morimoto; JC Reed

  EMBO JOURNAL, 1997年08月, 査読有り

  

MISC

• Ubc13ヘテロ欠損マウスにおける肥満とインスリン抵抗性改善機序の検討

  城尾 恵里奈; 福島 徹; 原田 範雄; 松澤 秀一; Reed John C.; 稲垣 暢也

  糖尿病, 2014年04月

  
• 低酸素による細胞死を抑制する新規低分子化合物はALSの進行を抑制する

  星野友則; 星野友則; 松澤秀一; 松澤秀一; 高橋良輔

  日本生化学会大会(Web), 2018年

  
• 脂質酸化依存的細胞死フェロトーシスを抑制する新規化合物の神経保護効果

  星野友則; 星野友則; 松澤秀一; 松澤秀一; 高橋良輔

  日本Cell Death学会学術集会プログラム抄録集, 2018年

  
• α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.

  Tomoyuki Taguchi; Masashi Ikuno; Mari Hondo; Laxmi Kumar Parajuli; Katsutoshi Taguchi; Jun Ueda; Masanori Sawamura; Shinya Okuda; Etsuro Nakanishi; Junko Hara; Norihito Uemura; Yusuke Hatanaka; Takashi Ayaki; Shuichi Matsuzawa; Masaki Tanaka; Omar M A El-Agnaf; Masato Koike; Masashi Yanagisawa; Maiko T Uemura; Hodaka Yamakado; Ryosuke Takahashi

  Brain : a journal of neurology, 2020年01月01日

  
• PTK7 Is Involved in the Chemotherapy Resistance of T-Cell Acute Lymphoblastic Leukemia through Interaction with FADD-Death Domain

  Hideki Goto; Rachel Wilkie Grantham; Motoaki Mizuuchi; Tetsuji Yamaguchi; Takanori Teshima; John C. Reed; Shu-ichi Matsuzawa

  BLOOD, 2015年12月

  
• Ubc13 Haploinsufficinecy Protects Against Age-related Insulin Resistance and High-Fat Diet-induced Obesity

  Erina Joo; Toru Fukushima; Norio Harada; Shu-Ichi Matsuzawa; John C. Reed; Nobuya Inagaki

  DIABETES, 2014年06月

  
• Novel phosphorylation and ubiquitination sites regulate ROS-dependent degradation of c-FLIP and sensitization of cancer cells to TRAIL

  Rachel P. Wilkie-Grantham; Shu-ichi Matsuzawa; John C. Reed

  CANCER RESEARCH, 2013年04月

  
• Discovery and Characterization of Chemical Inhibitors of UBC13.

  Charitha Madiraju; Shu-ichi Matsuzawa; Robert Ardecky; Ian Pass; Tram Ngo; Yasuko Matsuzawa; Carina Wimer; Michael Cuddy; Paul Diaz; Correa Ricardo; Craig Tamble; Chih-Wen Shu; Anthony Pinkerton; Eduard Sergienko; Chris Hassig; Thomas Chung; John C. Reed

  BLOOD, 2012年11月

  
• Ubiquitin-conjugating enzyme ubc13 is a critical component of TRAF-mediated inflammatory responses.

  Toru Fukushima; Shu-ichi Matsuzawa; Christinia L. Kress; Jean Marie Bruey; Maryla Krajewska; Sophie Lefebvre; Juan M. Zapata; Ze'ev Ronai; John C. Reed; Shinichi Kitada

  BLOOD, 2006年11月

  
• Caspase-activating protein Nalp1 is directly suppressed by Bcl-2 and Bcl-XI.

  Jean Marie Bruey; Nathalie Bruey-Sedano; Frederic Luciano; Dayong Zhai; Andrei Osterman; Shu-ichi Matsuzawa; Alexey Terskikh; Benjamin Faustin; John C. Reed

  BLOOD, 2006年11月

  
• p53-inducible human homologue of Drosophila seven in absentia (siah) inhibits cell growth and promotes apoptosis: Suppression by BAG-1/HAP-1.

  S Matsuzawa; S Takayama; B Froesch; JM Zapata; JC Reed

  BLOOD, 1997年11月

  

大学運営

部局運営(役職等)

• 自 2023年06月27日, 至 2024年06月26日

  京都大学サンディエゴ研究施設運営委員会_委員
• 自 2021年06月27日, 至 2023年06月26日

  京都大学サンディエゴ研究施設運営委員会　委員