癌関連遺伝子発現に関連するDNAメチル化異常は、C型肝炎ウイルス治療後も残存する(Aberrant DNA methylation changes associated with oncogenic transcriptomic profile remained after the eradication of HCV)
肝細胞癌におけるdMMR関連変異シグネチャーに着目した、免疫チェックポイント阻害薬の治療効果予測(Predicting Efficacy of Immune Checkpoint Inhibitors with dMMR-related Mutational Signatures in Hepatocellular Carcinoma)
CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study.
MSH2は細胞周期を制御することで肝癌の進行に抑制的に働くほか、脂質代謝にも影響を及ぼす(MSH2 has a suppressive role in liver cancer progression via the regulation of cell cycle and changes lipid metabolism)
Integrated analyses of the genetic and clinicopathological features of cholangiolocarcinoma: cholangiolocarcinoma may be characterized by mismatch-repair deficiency.
Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma: Current evidence and future perspectives.
Masayuki Ueno; Haruhiko Takeda; Atsushi Takai; Hiroshi Seno
Genetic Landscape of Multistep Hepatocarcinogenesis.
Haruhiko Takeda; Atsushi Takai; Yuji Eso; Ken Takahashi; Hiroyuki Marusawa; Hiroshi Seno
Cancers, 2022年01月23日
Pretreatment Neutrophil-to-Lymphocyte Ratio as a Predictive Marker of Response to Atezolizumab Plus Bevacizumab for Hepatocellular Carcinoma.
Yuji Eso; Haruhiko Takeda; Kojiro Taura; Atsushi Takai; Ken Takahashi; Hiroshi Seno
Current oncology (Toronto, Ont.), 2021年10月14日
Author Correction: DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis.
Eriko Iguchi; Atsushi Takai; Haruhiko Takeda; Ken Kumagai; Soichi Arasawa; Yuji Eso; Takahiro Shimizu; Yoshihide Ueda; Hiroyuki Marusawa; Hiroshi Seno
Scientific reports, 2021年07月01日
Mac-2 binding protein glycosylation isomer predicts tolerability and clinical outcome of lenvatinib therapy for hepatocellular carcinoma.
Yuji Eso; Shigeharu Nakano; Masako Mishima; Soichi Arasawa; Eriko Iguchi; Haruhiko Takeda; Atsushi Takai; Ken Takahashi; Kojiro Taura; Hiroshi Seno
Journal of hepato-biliary-pancreatic sciences, 2021年06月
A simplified method to quantitatively predict the effect of lenvatinib on hepatocellular carcinoma using contrast-enhanced ultrasound with perfluorobutane microbubbles.
Yuji Eso; Shigeharu Nakano; Masako Mishima; Soichi Arasawa; Eriko Iguchi; Haruhiko Takeda; Atsushi Takai; Ken Takahashi; Hiroshi Seno
Quantitative imaging in medicine and surgery, 2021年06月
DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis.
Eriko Iguchi; Atsushi Takai; Haruhiko Takeda; Ken Kumagai; Soichi Arasawa; Yuji Eso; Takahiro Shimizu; Yoshihide Ueda; Hiroyuki Marusawa; Hiroshi Seno
Branched-chain amino acid to tyrosine ratio is an essential pre-treatment factor for maintaining sufficient treatment intensity of lenvatinib in patients with hepatocellular carcinoma.
Yuji Eso; Shigeharu Nakano; Masako Mishima; Soichi Arasawa; Eriko Iguchi; Haruhiko Takeda; Atsushi Takai; Ken Takahashi; Hiroshi Seno
Journal of hepato-biliary-pancreatic sciences, 2020年12月
Hes1 Is Essential in Proliferating Ductal Cell-Mediated Development of Intrahepatic Cholangiocarcinoma.
Single-molecular real-time deep sequencing reveals the dynamics of multi-drug resistant haplotypes and structural variations in the hepatitis C virus genome.
Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing.
Comparison of standard-dose and half‑dose sorafenib therapy on clinical outcome in patients with unresectable hepatocellular carcinoma in field practice: A propensity score matching analysis.
Clinical significance of early interventional therapy of branched-chain amino acid granules in patients with hepatocellular carcinoma: propensity score matching analysis.
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2014年01月
Comparison of transcatheter arterial chemoembolization and transcatheter arterial chemotherapy infusion for patients with intermediate-stage hepatocellular carcinoma.
Journal of gastrointestinal and liver diseases : JGLD, 2013年06月
The effect of long-term supplementation with branched-chain amino acid granules in patients with hepatitis C virus-related hepatocellular carcinoma after radiofrequency thermal ablation.
Transcatheter arterial infusion chemotherapy prior to radiofrequency thermal ablation for single hepatocellular carcinoma reduces the risk of intrahepatic distant recurrence.
Percutaneous radiofrequency ablation therapy for hepatocellular carcinoma: a proposed new grading system for the ablative margin and prediction of local tumor progression and its validation.
A case of advanced hepatocellular carcinoma with portal vein tumor thrombus refractory to epirubicin that showed marked decrease in tumor markers after transcatheter arterial infusion with miriplatin.
C型肝炎ウイルスにより生じるDNAメチル化異常による癌関連遺伝子発現プロファイルはウイルス治療後も残存する(HCV-driven methylation change with oncogenic gene expression profile was sustained in the liver after viral eradication.)
TERTの高発現はNF-KB経路の活性化を介して肝発癌ポテンシャルを上昇させる(TERT upregulation increases the potential of hepatocarcinogenesis via the activation of NF-KB signaling pathway)