Basic Information

Affiliated programs (koza)

• Graduate School of Engineering, 高分子化学専攻, 助教

Professional Memberships

• From Jul. 2023, To Present

  「細胞を創る」研究会
• From Jul. 2019, To Present

  Japanease Society for Extracellular Vesicles
• From Jul. 2019, To Present

  The Molecular Biology Society of Japan
• From Nov. 2017, To Present

  無細胞生命科学研究会
• From Aug. 2015, To Present

  THE JAPANESE SOCIETY FOR BIOMATERIALS
• From Jun. 2014, To Present

  THE SOCIETY OF POLYMER SCIENCE, JAPAN
• From Mar. 2009, To Present

  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

Academic Degree

• 修士（薬学）(京都大学)
• 博士（薬学）(京都大学)

Research History

• From Apr. 2022, To Present

  Institute for Life and Medical Sciences, Kyoto University, Department of Regeneration Science and Engineering, Assistant Professor
• From May 2021, To Mar. 2022

  Institute for Frontier Life and Medical Sciences, Kyoto University, Department of Regeneration Science and Engineering, Assistant Professor
• From Apr. 2021, To Apr. 2021

  Institute for Frontier Life and Medical Sciences, Kyoto University, Department of Regeneration Science and Engineering, Research assistant
• From Apr. 2014, To Mar. 2021

  Kyoto University, Graduate School of Engineering, 特定研究員
• From Feb. 2021, To Feb. 2021

  Okinawa Institute of Science and Technology Graduate University, Imaging Section, CryoEM trainee
• From Apr. 2018, To Mar. 2020

  JST-CREST [Extracellular Fine Particles], CREST-postdoctoral researcher
• From Jan. 2020, To Jan. 2020

  Okinawa Institute of Science and Technology Graduate University, Imaging Section, CryoEM trainee
• From Apr. 2017, To Mar. 2018

  Japan Science and Technology Agency, プロテオリポソーム工学 グループリーダー
• From Apr. 2014, To Mar. 2018

  Japan Science and Technology Agency, 特定研究員
• From Apr. 2013, To Mar. 2014

  日本学術振興会, 特別研究員(PD)
• From Apr. 2012, To Mar. 2013

  日本学術振興会, 特別研究員(DC2)
• From Apr. 2007, To Mar. 2008

  Kyoto University, Faculty of Pharmaceutical Sciences, 研究生

ID,URL

• ORCID ID

  0000-0001-8808-9713

• J-Global ID

  201801018787616334

• Researcher number

  70737460

researchmap URL

• https://researchmap.jp/matsuri-ando

Research

Research Interests

• 遺伝子工学
• タンパク質工学
• 遺伝子治療
• バイオマテリアル
• ドラッグデリバリーシステム
• プロテオリポソーム
• 無細胞タンパク質合成

Research Areas

• Nanotechnology/Materials, Nanobioscience
• Life sciences, Clinical pharmacy
• Life sciences, Biomaterials
• Life sciences, Biomedical engineering

Papers

• Mesenchymal Stem Cell Membrane Coating of Gelatin Nanospheres with Drug Release Ability for Inflammatory Tissue Targeting

  Keisuke Moriyama; Mitsuru Ando; Kazuo Sakurai; Isamu Sakurai; Yasuhiko Tabata

  bioRxiv, Jun. 2025, Corresponding author

  
• Association with Cationized Gelatin Nanospheres Enhances Mitochondria Uptake and Membrane Potential.

  Wenxuan Yang; Satoshi Abe; Mitsuru Ando; Yasuhiko Tabata

  Tissue engineering. Part A, 10 Dec. 2024

  
• Distribution and Incorporation of Extracellular Vesicles into Chondrocytes and Synoviocytes.

  Takashi Ohtsuki; Ikumi Sato; Ren Takashita; Shintaro Kodama; Kentaro Ikemura; Gabriel Opoku; Shogo Watanabe; Takayuki Furumatsu; Hiroshi Yamada; Mitsuru Ando; Kazunari Akiyoshi; Keiichiro Nishida; Satoshi Hirohata

  International journal of molecular sciences, 06 Nov. 2024

  
• Manipulation of Macrophage Uptake by Controlling the Aspect Ratio of Graft Copolymer Micelles.

  Yusuke Sakamoto; Shota Fujii; Shin Takano; Jokichi Fukushima; Mitsuru Ando; Noriyuki Kodera; Tomoki Nishimura

  Nano letters, 15 May 2024, Peer-reviewed

  
• A Simple Preparation Method of Gelatin Hydrogels Incorporating Cisplatin for Sustained Release.

  Takahisa Suzuki; Shigeru Tsunoda; Kota Yamashita; Toshie Kuwahara; Mitsuru Ando; Yasuhiko Tabata; Kazutaka Obama

  Pharmaceutics, 25 Nov. 2022, Peer-reviewed

  
• Single-component nanodiscs via the thermal folding of amphiphilic graft copolymers with the adjusted flexibility of the main chain.

  Tomoki Nishimura; Yusuke Hatatani; Mitsuru Ando; Yoshihiro Sasaki; Kazunari Akiyoshi

  Chemical science, 11 May 2022, Peer-reviewed

  
• Preparation of cationic proteoliposomes using cell-free membrane protein synthesis: the chaperoning effect of cationic liposomes

  Mitsuru Ando; Yoshihiro Sasaki; Kazunari Akiyoshi

  RSC ADVANCES, Aug. 2020, Peer-reviewed, Lead author

  
• Proteoliposome Engineering with Cell-Free Membrane Protein Synthesis: Control of Membrane Protein Sorting into Liposomes by Chaperoning Systems.

  Ando M; Schikula S; Sasaki Y; Akiyoshi K

  Advanced science (Weinheim, Baden-Wurttemberg, Germany), Oct. 2018, Peer-reviewed, Lead author

  
• Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene Therapy

  Mitsuru Ando; Mai Fujimoto; Yuki Takahashi; Makiya Nishikawa; Atsushi Hamana; Yoshinobu Takakura

  JOURNAL OF PHARMACEUTICAL SCIENCES, Mar. 2017, Peer-reviewed, Lead author

  
• Liposome chaperon in cell-free membrane protein synthesis: one-step preparation of KcsA-integrated liposomes and electrophysiological analysis by the planar bilayer method

  M. Ando; M. Akiyama; D. Okuno; M. Hirano; T. Ide; S. Sawada; Y. Sasaki; K. Akiyoshi

  BIOMATERIALS SCIENCE, 2016, Peer-reviewed, Lead author

  
• Comprehensive study of liposome-assisted synthesis of membrane proteins using a reconstituted cell-free translation system

  Tatsuya Niwa; Yoshihiro Sasaki; Eri Uemura; Shugo Nakamura; Minato Akiyama; Mitsuru Ando; Shinichi Sawada; Sada-atu Mukai; Takuya Ueda; Hideki Taguchi; Kazunari Akiyoshi

  SCIENTIFIC REPORTS, Dec. 2015, Peer-reviewed

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• Contribution of epigenetic modifications to the decline in transgene expression from plasmid DNA in mouse liver

  Lei Zang; Makiya Nishikawa; Mitsuru Ando; Yuki Takahashi; Yoshinobu Takakura

  Pharmaceutics, 09 Aug. 2015, Peer-reviewed

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• Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon gamma gene transfer on interferon gamma-mediated antitumor activity

  K. W Watcharanurak; L. Zang; M. Nishikawa; K. Yoshinaga; Y. Yamamoto; Y. Takahashi; M. Ando; K. Saito; Y. Watanabe; Y. Takakura

  GENE THERAPY, Sep. 2014, Peer-reviewed

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• Enhancement of Anticancer Effect of Interferon-gamma Gene Transfer against Interferon-gamma-Resistant Tumor by Depletion of Tumor-Associated Macrophages

  Tsuyoshi Kiyota; Yuki Takahashi; Kanitta Watcharanurak; Makiya Nishikawa; Saori Ohara; Mitsuru Ando; Yoshihiko Watanabe; Yoshinobu Takakura

  MOLECULAR PHARMACEUTICS, May 2014, Peer-reviewed

  
• Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer

  Yuki Takahashi; Mitsuru Ando; Makiya Nishikawa; Nobuhiko Hiraga; Michio Imamura; Kazuaki Chayama; Yoshinobu Takakura

  HUMAN GENE THERAPY CLINICAL DEVELOPMENT, Mar. 2014, Peer-reviewed, Lead author

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• Prevention of adverse events of interferon gamma gene therapy by gene delivery of interferon gamma-heparin-binding domain fusion protein in mice

  Mitsuru Ando; Yuki Takahashi; Takuma Yamashita; Mai Fujimoto; Makiya Nishikawa; Yoshihiko Watanabe; Yoshinobu Takakura

  MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2014, Peer-reviewed, Lead author

  
• Expression Profile-Dependent Improvement of Insulin Sensitivity by Gene Delivery of Interleukin-6 in a Mouse Model of Type II Diabetes

  Hanae Mukumoto; Yuki Takahashi; Mitsuru Ando; Makiya Nishikawa; Yoshinobu Takakura

  MOLECULAR PHARMACEUTICS, Oct. 2013, Peer-reviewed

  
• Gene Delivery of Albumin Binding Peptide-Interferon-gamma Fusion Protein with Improved Pharmacokinetic Properties and Sustained Biological Activity

  Noriko Miyakawa; Makiya Nishikawa; Yuki Takahashi; Mitsuru Ando; Masayuki Misaka; Yoshihiko Watanabe; Yoshinobu Takakura

  JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2013, Peer-reviewed

  
• Obstacles and Approaches to the Development of Gene Therapy and Nucleic Acid-based Drug Foreword

  Kahori Shimizu; Mitsuru Ando

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2012, Peer-reviewed

  
• Control of Spatiotemporal Distribution of Interferon gamma by Genetically Fusing Functional Peptides

  Mitsuru Ando; Yuki Takahashi; Makiya Nishikawa; Yoshinobu Takakura

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2012, Peer-reviewed, Lead author

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• Constant and steady transgene expression of interferon-gamma by optimization of plasmid construct for safe and effective interferon-gamma gene therapy

  Mitsuru Ando; Yuki Takahashi; Makiya Nishikawa; Yoshihiko Watanabe; Yoshinobu Takakura

  JOURNAL OF GENE MEDICINE, Apr. 2012, Peer-reviewed, Lead author

  
• Inhibition of nuclear delivery of plasmid DNA and transcription by interferon gamma: hurdles to be overcome for sustained gene therapy

  L. Zang; M. Nishikawa; K. Machida; M. Ando; Y. Takahashi; Y. Watanabe; Y. Takakura

  GENE THERAPY, Sep. 2011, Peer-reviewed

  
• Prolonged Circulation Half-life of Interferon gamma Activity by Gene Delivery of Interferon gamma-Serum Albumin Fusion Protein in Mice

  Noriko Miyakawa; Makiya Nishikawa; Yuki Takahashi; Mitsuru Ando; Masayuki Misaka; Yoshihiko Watanabe; Yoshinobu Takakura

  JOURNAL OF PHARMACEUTICAL SCIENCES, Jun. 2011, Peer-reviewed

  
• Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors

  Yuki Takahashi; Elin Vikman; Makiya Nishikawa; Mitsuru Ando; Yoshihiko Watanabe; Yoshinobu Takakura

  JOURNAL OF GENE MEDICINE, Sep. 2010, Peer-reviewed

  
• Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression

  Masaru Mitsui; Makiya Nishikawa; Lei Zang; Mitsuru Ando; Kayoko Hattori; Yuki Takahashi; Yoshihiko Watanabe; Yoshinobu Takakura

  JOURNAL OF GENE MEDICINE, May 2009, Peer-reviewed

  

Misc.

• Is the advanced application of membrane protein as biomaterials just around next corner?

  Ando Mitsuru

  Drug Delivery System, 25 Jan. 2022, Lead author

  
• Proteo-liposome Engineering: Chaperoning Science for Preparation of Membrane Protein-reconstituted Liposomes

  安藤満; 吉田昭介; 澤田晋一; 秋吉一成

  膜, 2014, Lead author

  

Presentations

• 機能性材料としての膜タンパク質：集積技術と機能発現

  安藤 満

  2024 KIPS 若手高分子シンポジウム, 25 Oct. 2024, Invited

  
• 機能性材料として膜タンパク質を利用するためには

  安藤 満

  信州大学 講演会（バイオ、ソフトマテリアル）, Nov. 2023, Invited

  
• 膜タンパク質を自在に利用するためのシャペロン技術の開発に関する研究

  安藤 満

  ウイルス・再生医科学研究所セミナー, Mar. 2021, Invited

  
• Membrane Protein Science toward Utilization as Functional Bio-devices

  Mitsuru Ando

  Biomaterial Seminar, Tsukuba, Mar. 2020, Invited

  
• Development of Interferon γ-Based Cancer Gene Therapy by Genetically Fusing Interferon γ with Functional Peptides

  Mitsuru Ando

  Global Education Seminar West 2014, Dec. 2014, Invited

  
• 機能性ペプチド融合によるIFN-γ時空間制御

  安藤 満; 高橋 有己; 西川 元也; 高倉 喜信

  日本薬学会 第132年会, Mar. 2012, Invited

  

Industrial Property Rights

• WO2016-167367, JP2016062184, 標的化両親媒性ナノキャリア及びその製造方法

  秋吉 一成; 安藤 満; 三浦 理紗子; 澤田 晋一; 珠玖 洋; 赤堀 泰

  

External funds: Kakenhi

• Design and preparation of the fusogenic proteoliposomes by cell-free protein synthesis / liposome system

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Mitsuru Ando

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  膜融合性膜タンパク質;無細胞タンパク質合成;プロテオリポソーム;膜融合;膜タンパク質;リポソーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K21119/
• Development of platelet-like nanoparticle to control tissue inflammation

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  安藤 満

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  血小板;徐放化技術;創傷治癒;DDS;ゼラチン粒子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03923/
• Graft Polymer Discs: A Novel Platform for Membrane Protein Analysis

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 35:Polymers, organic materials, and related fields

  Shinshu University

  Tomoki Nishimura

  From 30 Jun. 2022, To 31 Mar. 2024, Project Closed

  ナノディスク;膜タンパク質;グラフトポリマー;無細胞タンパク質合成;自己組織化;ポリマーディスク

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19057/
• Development of platelet-like nanoparticle to control tissue inflammation

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  安藤 満

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  血小板;徐放担体;標的指向性;細胞膜被覆粒子;ゼラチン;徐放化技術;ゼラチン粒子;創傷治癒;DDS

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K25177/
• オルガネラ機能の再構成による細胞オペレーション技術の創出

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  安藤 満

  From 28 Jun. 2024, To 31 Mar. 2028, Granted

  オルガネラ機能再構成;膜タンパク質;無細胞タンパク質合成;ハイブリッド粒子;エネルギー産生

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21340/

Education

Student achievements: Awards

• Presentation Award: The 19th Symposium for Young Scientists of Japanese Society for Biomaterials at Kansai

  Keisuke Moriyama, Japanese Society for Biomaterials at Kansai, 27 Jul. 2024
• The 40th Annual Meeting of Japan Society of Drug Delivery System Journal Award - Acta Biomaterialia

  Wenxuan Yang, The Japan Society of Drug Delivery System, Nov. 2407
• The 23rd Congress of the Japanese Society for Regenerative Medicine Presentation Award

  Wenxuan Yang, The Japanese Society for Regenerative Medicine, 23 Mar. 2024
• The 39th Annual Meeting of the Japan Society of Drug Delivery System Presentation Award

  Keisuke Moriyama, The Japan Society of Drug Delivery System, 28 Jul. 2023

Administration

Faculty management (title, position)

• From 01 Apr. 2023

  共同利用機器等委員会　委員
• From 01 Apr. 2022, To 31 Mar. 2023

  医生物学研究所教員会議運営委員
• From 01 Jul. 2021

  再生実験動物施設飼育室施設運営委員会 委員
• From May 2021

  化学物質管理委員会　委員

Academic, Social Contribution

Academic Contribution

• The

  Planning, management, etc., Other

  高分子若手研究会[関西], From 25 Apr. 2025, To Present

  
• 第40回 日本DDS学会学術集会 一般演題優秀発表賞(ポスター) 審査

  Supervision (editorial)

  日本DDS学会, From 09 Jul. 2024, To 11 Jul. 2024

  
• 第40回 日本DDS学会学術集会 一般演題座長 (English1 session:Materials、English3 session: Targeting)

  Panel moderator

  日本DDS学会, From 09 Jul. 2024, To 11 Jul. 2024

  
• 第40回日本DDS学会学術集会 ポスターセッション座長(マテリアル)

  Panel moderator

  日本DDS学会, From 09 Jul. 2024, To 11 Jul. 2024

  
• 日本バイオマテリアル学会関西ブロック世話人会

  Planning, management, etc., Other

  From Jun. 2023, To Present

  
• DDS再生医療研究会 世話人

  Planning, management, etc., Other

  From Nov. 2021, To Present