Basic Information

Academic Degree

• 博士（医学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程脳統御医科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

High School

• High School

  三重高田高等学校

Research History

• From Apr. 2019, To Present

  京都大学医学部附属病院, 脳神経内科, 特定准教授
• From Apr. 2011, To Mar. 2019

  京都大学医学部附属病院, 神経内科, 助教
• From Jul. 2015, To Jan. 2017

  UC San Diego, Neuroscience, visiting scholar
• From Sep. 2010, To Mar. 2011

  医仁会武田総合病院, 神経内科, 医長
• From Apr. 2009, To Aug. 2010

  京都大学医学部附属病院, 神経内科, 助教
• From Apr. 2005, To Mar. 2009

  Kyoto University, Graduate School of Medicine, 大学院生
• From Apr. 2003, To Mar. 2005

  京都大学医学部附属病院, 神経内科, 医員
• From Apr. 2000, To Mar. 2003

  虎の門病院, 内科, 研修医

Language of Instruction

• Japanese

ID,URL

• J-Global ID

  201401015377937169

• Researcher number

  10378771

researchmap URL

• https://researchmap.jp/7000008893

Research

Research Topics, Overview of the research

• Research Topics

  Molecular biology of neurodegenerative disorders

• Overview of the research

  My research is fosused on the development of model for Parkinson's disease and multiple system atrophy using mice, rat, medaka fish and patients-derived iPS cells as well as investigation of pathomechanisms underlying PD and development of novel therapeutics for PD.

Research Interests

• プリオン
• α-シヌクレイン
• バイオマーカー
• 動物モデル
• 多系統萎縮症
• パーキンソン病

Research Areas

• Life sciences, Neurology

Papers

• Enhanced alpha-synuclein pathology and exacerbated motor dysfunction in alpha-synuclein transgenic mice with autophagy deficiency.

  Sachiko Noda; Shigeto Sato; Hodaka Yamakado; Ryosuke Takahashi; Nobutaka Hattori

  Biochemical and biophysical research communications, 19 Feb. 2025

  
• A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson’s disease

  Mitsuaki Kashiwagi; Goichi Beck; Mika Kanuka; Yoshifumi Arai; Kaeko Tanaka; Chika Tatsuzawa; Yumiko Koga; Yuki C. Saito; Marina Takagi; Yo Oishi; Masanori Sakaguchi; Kousuke Baba; Masashi Ikuno; Hodaka Yamakado; Ryosuke Takahashi; Masashi Yanagisawa; Shigeo Murayama; Takeshi Sakurai; Kazuya Sakai; Yoshimi Nakagawa; Masahiko Watanabe; Hideki Mochizuki; Yu Hayashi

  Cell, Sep. 2024

  
• Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson's disease.

  Nobukatsu Sawamoto; Daisuke Doi; Etsuro Nakanishi; Masanori Sawamura; Takayuki Kikuchi; Hodaka Yamakado; Yosuke Taruno; Atsushi Shima; Yasutaka Fushimi; Tomohisa Okada; Tetsuhiro Kikuchi; Asuka Morizane; Satoe Hiramatsu; Takayuki Anazawa; Takero Shindo; Kentaro Ueno; Satoshi Morita; Yoshiki Arakawa; Yuji Nakamoto; Susumu Miyamoto; Ryosuke Takahashi; Jun Takahashi

  Nature, 16 Apr. 2025

  
• αシヌクレイン伝播モデルマウスにおける睡眠構造の変化について

  江川 斉宏; 奥田 真也; 原 淳子; 上村 紀仁; 生野 真嗣; 山門 穂高; 高橋 良輔

  日本睡眠学会定期学術集会プログラム・抄録集, Jun. 2019

  
• Involvement of the basal forebrain and hippocampus in memory deficits in Parkinson's disease.

  Haruhi Sakamaki-Tsukita; Atsushi Shima; Daisuke Kambe; Koji Furukawa; Akira Nishida; Ikko Wada; Kenji Yoshimura; Yusuke Sakato; Yuta Terada; Hodaka Yamakado; Yosuke Taruno; Etsuro Nakanishi; Masanori Sawamura; Yasutaka Fushimi; Tomohisa Okada; Yuji Nakamoto; Laszlo Zaborszky; Ryosuke Takahashi; Nobukatsu Sawamoto

  Parkinsonism & related disorders, Nov. 2024

  
• Neural substrates underlying distinct dual cognitive syndromes in Parkinson's disease.

  Kenji Yoshimura; Atsushi Shima; Daisuke Kambe; Koji Furukawa; Akira Nishida; Ikko Wada; Yusuke Sakato; Haruhi Sakamaki-Tsukita; Yuta Terada; Hodaka Yamakado; Yosuke Taruno; Etsuro Nakanishi; Masanori Sawamura; Koji Fujimoto; Yasutaka Fushimi; Tomohisa Okada; Yuji Nakamoto; Takashi Hanakawa; Ryosuke Takahashi; Nobukatsu Sawamoto

  European journal of neurology, Jan. 2025, Peer-reviewed

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• A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy.

  Masanori Sawamura; Kiyoshi Tachikawa; Rie Hikawa; Hisako Akiyama; Seiji Kaji; Ken Yasuda; Angel I Leu; Hyojung Hong; Rajesh Mukthavaram; Pad Chivukula; Hodaka Yamakado; Yoshio Hirabayashi; Ryosuke Takahashi; Shu-Ichi Matsuzawa

  Molecular therapy. Nucleic acids, 10 Dec. 2024

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• Delineating three distinct spatiotemporal patterns of brain atrophy in Parkinson's disease.

  Yusuke Sakato; Atsushi Shima; Yuta Terada; Kiyoaki Takeda; Haruhi Sakamaki-Tsukita; Akira Nishida; Kenji Yoshimura; Ikko Wada; Koji Furukawa; Daisuke Kambe; Hiroki Togo; Yohei Mukai; Masanori Sawamura; Etsuro Nakanishi; Hodaka Yamakado; Yasutaka Fushimi; Tomohisa Okada; Yuji Takahashi; Yuji Nakamoto; Ryosuke Takahashi; Takashi Hanakawa; Nobukatsu Sawamoto

  Brain : a journal of neurology, 24 Oct. 2024

  
• Frontoparietal-Striatal Network and Nucleus Basalis Modulation in Patients With Parkinson Disease and Gait Disturbance.

  Akira Nishida; Atsushi Shima; Daisuke Kambe; Koji Furukawa; Haruhi Sakamaki-Tsukita; Kenji Yoshimura; Ikko Wada; Yusuke Sakato; Yuta Terada; Masanori Sawamura; Etsuro Nakanishi; Yosuke Taruno; Hodaka Yamakado; Yasutaka Fushimi; Tomohisa Okada; Yuji Nakamoto; Ryosuke Takahashi; Nobukatsu Sawamoto

  Neurology, 13 Aug. 2024

  
• A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

  Tomoyuki Ishimoto; Miki Oono; Seiji Kaji; Takashi Ayaki; Katsuya Nishida; Itaru Funakawa; Takakuni Maki; Shu-ichi Matsuzawa; Ryosuke Takahashi; Hodaka Yamakado

  Molecular Brain, 24 May 2024

  
• Experimental Animal Models of Prodromal Parkinson's Disease.

  Hodaka Yamakado; Ryosuke Takahashi

  Journal of Parkinson's disease, 24 Feb. 2024

  
• 亜急性発症のミオクロニーてんかんの一例

  十河 正弥; 戸島 麻耶; 錦織 隆成; 濱口 敏和; 下竹 昭寛; 木村 公俊; 岡田 信久; 當間 圭一郎; 眞木 崇州; 山門 穂高; 高橋 良輔; 池田 昭夫

  てんかん研究, Sep. 2019

  
• A Rapid, Sensitive, and Specific Detection of Aggregated α-Synuclein by a Liposome-Immobilized Cantilever Sensor

  Ryoko Kobayashi; Kotaro Kamitani; Masanori Sawamura; Hodaka Yamakado; Ryosuke Takahashi; Masayuki Sohgawa; Minoru Noda

  IEEE Sensors Journal, 15 Jun. 2023, Peer-reviewed

  
• Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs.

  Masanori Sawamura; Junichiro Ohira; Rie Hikawa; Tomoyuki Ishimoto; Etsuro Nakanishi; Hodaka Yamakado; Ryosuke Takahashi

  Parkinsonism & related disorders, 20 May 2023

  
• A RaPID Macrocyclic Peptide That Inhibits the Formation of α-Synuclein Amyloid Fibrils.

  Tatsuya Ikenoue; Miki Oono; Masatomo So; Hodaka Yamakado; Toshiaki Arata; Ryosuke Takahashi; Yasushi Kawata; Hiroaki Suga

  Chembiochem : a European journal of chemical biology, 25 Apr. 2023

  
• Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission.

  Jun Ueda; Norihito Uemura; Tomoyuki Ishimoto; Tomoyuki Taguchi; Masanori Sawamura; Etsuro Nakanishi; Masashi Ikuno; Shuichi Matsuzawa; Hodaka Yamakado; Ryosuke Takahashi

  Movement disorders, 17 Apr. 2023

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• 抗ミトコンドリア抗体陽性筋炎で下肢MRIに大内転筋に特徴的なSTIR高信号を認めた3例

  上田 紗希帆; 南山 素三雄; 山門 穂高; 山下 博史; 中嶋 蘭; 細川 祐司; 山川 範之; 湯川 尚一郎; 澤本 伸克; 漆谷 真; 三森 経世; 高橋 良輔

  臨床神経学, Dec. 2014

  
• DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.

  Mingyue Jin; Sakiko Matsumoto; Takashi Ayaki; Hodaka Yamakado; Tomoyuki Taguchi; Natsuko Togawa; Ayumu Konno; Hirokazu Hirai; Hiroshi Nakajima; Shoji Komai; Ryuichi Ishida; Syuhei Chiba; Ryosuke Takahashi; Toshifumi Takao; Shinji Hirotsune

  Nature communications, 12 Nov. 2022

  
• Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice.

  Shinya Okuda; Takeo Nakayama; Norihito Uemura; Rie Hikawa; Masashi Ikuno; Hodaka Yamakado; Haruhisa Inoue; Naoko Tachibana; Yu Hayashi; Ryosuke Takahashi; Naohiro Egawa

  International journal of molecular sciences, 02 Nov. 2022

  
• Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.

  Masanori Sawamura; Hirotaka Onoe; Hideo Tsukada; Kaoru Isa; Hodaka Yamakado; Shinya Okuda; Masashi Ikuno; Yusuke Hatanaka; Shigeo Murayama; Norihito Uemura; Tadashi Isa; Ryosuke Takahashi

  Movement disorders, 21 Aug. 2022

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• Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation.

  Masanori Sawamura; Keiko Imamura; Rie Hikawa; Takako Enami; Ayako Nagahashi; Hodaka Yamakado; Hidenori Ichijo; Takao Fujisawa; Hirofumi Yamashita; Sumio Minamiyama; Misako Kaido; Hiromi Wada; Makoto Urushitani; Haruhisa Inoue; Naohiro Egawa; Ryosuke Takahashi

  Scientific reports, 25 Jul. 2022

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• An ultrasensitive detection of aggregated α-synuclein as a biomarker molecule for Parkinson disease by liposome-immobilized cantilever biosensor using self-templating phenomena of prionoid protein

  Ryoko Kobayashi; Masanori Sawamura; Hodaka Yamakado; Masayuki Sohgawa; Minoru Noda

  MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2020

  
• A New Detection of Biomarker Molecule of α-Synuclein for Parkinson Disease by Phospholipid Liposome-Immobilized Cantilever Microsensor with Temperature Stabilization

  Ryoko Kobayashi; Masanori Sawamura; Hodaka Yamakado; Masayuki Sohgawa; Minoru Noda

  2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Jun. 2019

  
• Periodic alternating gaze deviationを認めた原因不明の脳症の1症例

  大井 長和; 林 紗葵; 佐藤 啓; 真田 悠希; 長谷川 華子; 濱口 敏和; 眞木 崇州; 山門 穂高; 葛谷 聡; 松本 理器; 池田 昭夫; 高橋 良輔

  神経眼科, Nov. 2018, Peer-reviewed

  
• GBA2は神経型ゴーシェ病/GBA関連パーキンソン病の新たな修飾因子となりうるか

  中西 悦郎; 上村 紀仁; 秋山 央子; 木下 政人; 山門 穂高; 武田 俊一; 平林 義雄; 高橋 良輔

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, Jul. 2018, Peer-reviewed

  
• 神経型ゴーシェ病モデルメダカの病態におけるGBA2の役割

  中西 悦郎; 上村 紀仁; 秋山 央子; 木下 政人; 山門 穂高; 武田 俊一; 平林 義雄; 高橋 良輔

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, Oct. 2015, Peer-reviewed

  
• Motor progression and nigrostriatal neurodegeneration in Parkinson's disease.

  Koji Furukawa; Atsushi Shima; Daisuke Kambe; Akira Nishida; Ikko Wada; Haruhi Sakamaki; Kenji Yoshimura; Yuta Terada; Yusuke Sakato; Masahiro Mitsuhashi; Masanori Sawamura; Etsuro Nakanishi; Yosuke Taruno; Hodaka Yamakado; Yasutaka Fushimi; Tomohisa Okada; Yuji Nakamoto; Ryosuke Takahashi; Nobukatsu Sawamoto

  Annals of neurology, 15 Apr. 2022

  
• Rapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Mice

  Shinya Okuda; Norihito Uemura; Masanori Sawamura; Tomoyuki Taguchi; Masashi Ikuno; Maiko T. Uemura; Hodaka Yamakado; Ryosuke Takahashi

  Neurotherapeutics, 21 Dec. 2021, Peer-reviewed

  
• Mitochondrial dysfunction in a mouse model of prodromal Parkinson's disease: A metabolomic analysis.

  Masashi Ikuno; Hodaka Yamakado; Ikuko Amano; Yusuke Hatanaka; Norihito Uemura; Shu-Ichi Matsuzawa; Ryosuke Takahashi

  Neuroscience letters, 24 Sep. 2021, Peer-reviewed, Corresponding author

  
• Membranes and Organelle in Lewy Bodies: The Mastermind or the Bystander?

  Tomoyuki Ishimoto; Hodaka Yamakado

  Movement disorders, Sep. 2021, Peer-reviewed, Last author, Corresponding author

  
• The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy.

  Yutaka Inoue; Takashi Ayaki; Tomoyuki Ishimoto; Hodaka Yamakado; Takakuni Maki; Shuichi Matsuzawa; Nobukatsu Sawamoto; Ryosuke Takahashi

  Neuroscience letters, 24 May 2021, Peer-reviewed

  
• Impact of Gba2 on neuronopathic Gaucher's disease and α-synuclein accumulation in medaka (Oryzias latipes).

  Etsuro Nakanishi; Norihito Uemura; Hisako Akiyama; Masato Kinoshita; Sawamura Masanori; Yosuke Taruno; Hodaka Yamakado; Shu-Ichi Matsuzawa; Shunichi Takeda; Yoshio Hirabayashi; Ryosuke Takahashi

  Molecular brain, 10 May 2021, Peer-reviewed

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• Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models.

  Jun Ueda; Norihito Uemura; Masanori Sawamura; Tomoyuki Taguchi; Masashi Ikuno; Seiji Kaji; Yosuke Taruno; Shuichi Matsuzawa; Hodaka Yamakado; Ryosuke Takahashi

  Movement disorders, 04 Apr. 2021, Peer-reviewed

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• α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.

  Norihito Uemura; Jun Ueda; Toru Yoshihara; Masashi Ikuno; Maiko T Uemura; Hodaka Yamakado; Masahide Asano; John Q Trojanowski; Ryosuke Takahashi

  Movement disorders, 06 Feb. 2021, Peer-reviewed

  
• Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks

  M. Asada-Utsugi; K. Uemura; M. Kubota; Y. Noda; Y. Tashiro; T. M. Uemura; H. Yamakado; M. Urushitani; R. Takahashi; S. Hattori; T. Miyakawa; N. Ageta-Ishihara; K. Kobayashi; M. Kinoshita; A. Kinoshita

  Molecular Brain, Jan. 2021, Peer-reviewed

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• BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy.

  Seiji Kaji; Takakuni Maki; Jun Ueda; Tomoyuki Ishimoto; Yutaka Inoue; Ken Yasuda; Masanori Sawamura; Rie Hikawa; Takashi Ayaki; Hodaka Yamakado; Ryosuke Takahashi

  Acta neuropathologica communications, 29 Jul. 2020, Peer-reviewed

  
• Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

  Laxmi Kumar Parajuli; Ken Wako; Suiki Maruo; Soichiro Kakuta; Tomoyuki Taguchi; Masashi Ikuno; Hodaka Yamakado; Ryosuke Takahashi; Masato Koike

  eneuro, Jul. 2020, Peer-reviewed

  
• Susceptibility to erastin-induced ferroptosis decreases during maturation in a human oligodendrocyte cell line.

  Tomonori Hoshino; Hodaka Yamakado; Ryosuke Takahashi; Shu-Ichi Matsuzawa

  FEBS open bio, 01 Jul. 2020, Peer-reviewed

  
• Reduced Enhancement of Memory for Faces Encoded by Semantic and Socioemotional Processes in Patients with Parkinson's Disease.

  Paeksoon Park; Hodaka Yamakado; Ryosuke Takahashi; Shikiho Dote; Shiho Ubukata; Toshiya Murai; Takashi Tsukiura

  Journal of the International Neuropsychological Society : JINS, Apr. 2020, Peer-reviewed

  
• Animal Model for Prodromal Parkinson's Disease.

  Tomoyuki Taguchi; Masashi Ikuno; Hodaka Yamakado; Ryosuke Takahashi

  International journal of molecular sciences, 13 Mar. 2020, Peer-reviewed, Corresponding author

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• Limited spread of pathology within the brainstem of α-synuclein BAC transgenic mice inoculated with preformed fibrils into the gastrointestinal tract.

  Norihito Uemura; Hisashi Yagi; Maiko T Uemura; Hodaka Yamakado; Ryosuke Takahashi

  Neuroscience letters, 18 Jan. 2020, Peer-reviewed

  
• Thigh muscle MRI findings in myopathy associated with anti-mitochondrial antibody.

  Sumio Minamiyama; Sakiho Ueda; Ran Nakashima; Hodaka Yamakado; Yusuke Sakato; Hirofumi Yamashita; Nobukatsu Sawamoto; Ryota Fujimoto; Ichizo Nishino; Makoto Urushitani; Tsuneyo Mimori; Ryosuke Takahashi

  Muscle & nerve, Jan. 2020, Peer-reviewed, Corresponding author

  
• Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions.

  Seiji Kaji; Takakuni Maki; Tomoyuki Ishimoto; Hodaka Yamakado; Ryosuke Takahashi

  Translational neurodegeneration, 2020, Peer-reviewed

  
• α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.

  Tomoyuki Taguchi; Masashi Ikuno; Mari Hondo; Laxmi Kumar Parajuli; Katsutoshi Taguchi; Jun Ueda; Masanori Sawamura; Shinya Okuda; Etsuro Nakanishi; Junko Hara; Norihito Uemura; Yusuke Hatanaka; Takashi Ayaki; Shuichi Matsuzawa; Masaki Tanaka; Omar M A El-Agnaf; Masato Koike; Masashi Yanagisawa; Maiko T Uemura; Hodaka Yamakado; Ryosuke Takahashi

  Brain : a journal of neurology, 01 Jan. 2020, Peer-reviewed, Corresponding author

  
• TPPP/p25α Is an old and new therapeutic target in multiple system atrophy.

  Ishimoto T; Yamakado H

  Movement disorders, Nov. 2019, Peer-reviewed

  
• Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.

  Norihito Uemura; Hisashi Yagi; Maiko T Uemura; Yusuke Hatanaka; Hodaka Yamakado; Ryosuke Takahashi

  Molecular neurodegeneration, 26 Jul. 2019, Peer-reviewed

  
• GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease.

  Masashi Ikuno; Hodaka Yamakado; Hisako Akiyama; Laxmi Kumar Parajuli; Katsutoshi Taguchi; Junko Hara; Norihito Uemura; Yusuke Hatanaka; Katsumi Higaki; Kousaku Ohno; Masaki Tanaka; Masato Koike; Yoshio Hirabayashi; Ryosuke Takahashi

  Human molecular genetics, 01 Jun. 2019, Peer-reviewed, Corresponding author

  
• Homozygous 31 trinucleotide repeats in the SCA2 allele are pathogenic for cerebellar ataxia.

  Tojima M; Murakami G; Hikawa R; Yamakado H; Yamashita H; Takahashi R; Matsui M

  Neurology. Genetics, Dec. 2018, Peer-reviewed

  
• Ischemic Fasciitis of the Left Buttock in a 40-Year-Old Woman with Beta-Propeller Protein-Associated Neurodegeneration (BPAN)

  Akio Sakamoto; Ryuzo Arai; Takeshi Okamoto; Yosuke Yamada; Hodaka Yamakado; Shuichi Matsuda

  American Journal of Case Reports, 20 Oct. 2018, Peer-reviewed

  
• Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.

  Kim C; Spencer B; Rockenstein E; Yamakado H; Mante M; Adame A; Fields JA; Masliah D; Iba M; Lee HJ; Rissman RA; Lee SJ; Masliah E

  Molecular neurodegeneration, Aug. 2018, Peer-reviewed

  
• Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology.

  Fujita K; Homma H; Kondo K; Ikuno M; Yamakado H; Tagawa K; Murayama S; Takahashi R; Okazawa H

  eNeuro, Jul. 2018, Peer-reviewed

  
• Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.

  Uemura N; Yagi H; Uemura MT; Hatanaka Y; Yamakado H; Takahashi R

  Molecular neurodegeneration, May 2018, Peer-reviewed

  
• Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl.

  Hikiami R; Yamakado H; Tatsumi S; Ayaki T; Hashi Y; Yamashita H; Sawamoto N; Tsuji T; Urushitani M; Takahashi R

  Internal medicine, Feb. 2018, Peer-reviewed, Corresponding author

  
• Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity

  Maiko T. Uemura; Takeshi Asano; Rie Hikawa; Hodaka Yamakado; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, Nov. 2017, Peer-reviewed, Corresponding author

  
• Idiopathic Parkinson's Disease Patient-derived Induced Pluripotent Stem Cells Function as Midbrain Dopaminergic Neurons in Rodent Brains

  Tetsuhiro Kikuchi; Asuka Morizane; Daisuke Doi; Keisuke Okita; Masato Nakagawa; Hodaka Yamakado; Haruhisa Inoue; Ryosuke Takahashi; Jun Takahashi

  JOURNAL OF NEUROSCIENCE RESEARCH, Sep. 2017, Peer-reviewed

  
• Altered awareness of action in Parkinson's disease: evaluations by explicit and implicit measures

  Naho Saito; Keisuke Takahata; Hodaka Yamakado; Nobukatsu Sawamoto; Satoshi Saito; Ryosuke Takahashi; Toshiya Murai; Hidehiko Takahashi

  SCIENTIFIC REPORTS, Aug. 2017, Peer-reviewed

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• Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

  Elisabet Ihse; Hodaka Yamakado; Xander M. van Wijk; Roger Lawrence; Jeffrey D. Esko; Eliezer Masliah

  SCIENTIFIC REPORTS, Aug. 2017, Peer-reviewed

  
• Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases

  Hisanori Kinoshita; Hodaka Yamakado; Toshiyuki Kitano; Akihiro Kitamura; Hirofumi Yamashita; Masakazu Miyamoto; Takefumi Hitomi; Tomohisa Okada; Yuji Nakamoto; Nobukatsu Sawamoto; Akifumi Takaori-Kondo; Ryosuke Takahashi

  JOURNAL OF NEUROLOGY, Sep. 2016, Peer-reviewed, Corresponding author

  
• A case of variant biochemical phenotype of Niemann-Pick disease type C accompanying savant syndrome

  Mio Hamatani; Naoto Jingami; Kengo Uemura; Naoe Nakasone; Hisanori Kinoshita; Hodaka Yamakado; Haruaki Ninomiya; Ryosuke Takahashi

  Clinical Neurology, 2016, Peer-reviewed

  
• 精神症状で発症した再発性多発軟骨炎に脳炎を合併した一例

  前川 嵩太; 引網 亮太; 上田 紗希帆; 三嶋 亮; 狭間 雅章; 山門 穂高; 澤本 伸克; 漆谷 真; 高橋 良輔

  臨床神経学, Aug. 2015

  
• Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein

  Norihito Uemura; Masato Koike; Satoshi Ansai; Masato Kinoshita; Tomoko Ishikawa-Fujiwara; Hideaki Matsui; Kiyoshi Naruse; Naoaki Sakamoto; Yasuo Uchiyama; Takeshi Todo; Shunichi Takeda; Hodaka Yamakado; Ryosuke Takahashi

  PLOS GENETICS, Apr. 2015, Peer-reviewed

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• Advance in PD Research Explored a New Field on Ubiquitin Biology

  Hodaka Yamakado

  MOVEMENT DISORDERS, Sep. 2014, Peer-reviewed

  
• Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish

  Hideaki Matsui; Norihito Uemura; Hodaka Yamakado; Shunichi Takeda; Ryosuke Takahashi

  JOURNAL OF PARKINSONS DISEASE, 2014, Peer-reviewed

  
• Two cases of acute onset of focal cortical reflex myoclonus following acute aseptic meningoencephalitis with positive anti-glutamate receptor autoantibody

  Maya Tojima; Takefumi Hitomi; Naoto Jingami; Kosuke Tanioka; Hodaka Yamakado; Riki Matsumoto; Yukitoshi Takahashi; Akio Ikeda; Ryosuke Takahashi

  Clinical Neurology, 2014, Peer-reviewed

  
• Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction

  Eiko N. Minakawa; Hodaka Yamakado; Atsushi Tanaka; Kengo Uemura; Shunichi Takeda; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, Dec. 2013, Peer-reviewed

  
• Genetic correction will be a standard method for the patient-derived ips cell research?

  Ryosuke Takahashi; Hodaka Yamakado

  Movement Disorders, Dec. 2013, Peer-reviewed

  
• The Function of Parkin: Revisited

  Hodaka Yamakado; Ryosuke Takahashi

  MOVEMENT DISORDERS, Dec. 2013, Peer-reviewed

  
• 縦隔リンパ節の小細胞癌によるParaneoplastic extralimbic and limbic encephalitisを呈した1剖検例

  南山 素三雄; 上田 紗希帆; 濱谷 美緒; 綾木 孝; 山門 穂高; 竹内 康英; 池本 明人; 伊東 秀文; 澤本 伸克; 高橋 良輔

  神経免疫学, Nov. 2013

  
• Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice

  Natsumi Ageta-Ishihara; Hodaka Yamakado; Takao Morita; Satoko Hattori; Keizo Takao; Tsuyoshi Miyakawa; Ryosuke Takahashi; Makoto Kinoshita

  MOLECULAR BRAIN, Aug. 2013, Peer-reviewed

  
• PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates

  Hideaki Matsui; Roberto Gavinio; Takeshi Asano; Norihito Uemura; Hidefumi Ito; Yoshihito Taniguchi; Yoshito Kobayashi; Takakuni Maki; Jie Shen; Shunichi Takeda; Kengo Uemura; Hodaka Yamakado; Ryosuke Takahashi

  HUMAN MOLECULAR GENETICS, Jun. 2013, Peer-reviewed

  
• A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

  Silke Nuber; Florian Harmuth; Zacharias Kohl; Anthony Adame; Margaritha Trejo; Kai Schönig; Frank Zimmermann; Claudia Bauer; Nicolas Casadei; Christiane Giel; Carsten Calaminus; Bernd J. Pichler; Poul H. Jensen; Christian P. Müller; Davide Amato; Johannes Kornhuber; Peter Teismann; Hodaka Yamakado; Ryosuke Takahashi; Juergen Winkler; Eliezer Masliah; Olaf Riess

  Brain, 2013, Peer-reviewed

  
• Horner症候群が局在診断に役立ったTolosa-Hunt症候群の1例

  南山 素三雄; 陣上 直人; 山門 穂高; 猪原 匡史; 高橋 良輔

  自律神経, Jun. 2012

  
• alpha-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion

  Hodaka Yamakado; Yasuhiro Moriwaki; Nobuyuki Yamasaki; Tsuyoshi Miyakawa; Junko Kurisu; Kengo Uemura; Haruhisa Inoue; Makio Takahashi; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, Jun. 2012, Peer-reviewed

  
• Unverricht-Lundborg disease manifesting tremulous myoclonus with rare convulsive seizures: A case report

  Takayuki Kondo; Hodaka Yamakado; Jun Kawamata; Hidekazu Tomimoto; Takefumi Hitomi; Ryosuke Takahashi; Akio Ikeda

  Clinical Neurology, 2009, Peer-reviewed

  
• Cocaine and phenylephrine eye drop test for Parkinson disease

  H Sawada; K Yamakawa; H Yamakado; R Hosokawa; M Ohba; K Miyamoto; T Kawamura; S Shimohama

  JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Feb. 2005, Peer-reviewed

  

Misc.

• Is the GBA2 a new modifier for Gauchers's disease and GBA1-related Parkinson's disease?

  E. Nakanishi; N. Uemura; H. Akiyama; M. Kinoshita; H. Yamakado; S. Takeda; Y. Hirabayashi; R. Takahashi

  MOVEMENT DISORDERS, Jun. 2017

  
• FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像：若年発症例を含む4症例の検討

  引網亮太; 端祐一郎; 山門穂高; 辰己新水; 山下博史; 澤本伸克; 辻輝 之; 川本未知; 幸原伸夫; 井上治久; 漆谷真; 高橋良輔

  56th Annual Meeting of the Japanese Society of Neurology, Niigata., 21 May 2015

  
• iPS cell modeling of genetic Parkinson's disease

  Yasushi Koshiba; Hodaka Yamakado; Asuka Morizane; Tetsuhiro Kikuchi; Kazuko Hasegawa; Haruhisa Inoue; Jun Takahashi; Ryosuke Takahashi

  MOVEMENT DISORDERS, Nov. 2014

  
• Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain

  N. Uemura; H. Matsui; T. Fujiwara-Ishikawa; M. Kinoshita; M. Koike; H. Yamakado; K. Uemura; Y. Uchiyama; T. Todo; S. I. Takeda; R. Takahashi

  MOVEMENT DISORDERS, Jun. 2013

  
• alpha-synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior

  H. Yamakado; Y. Moriwaki; N. Yamasaki; T. Miyakawa; J. Kurisu; K. Uemura; H. Inoue; M. Takahashi; R. Takahashi

  MOVEMENT DISORDERS, Jun. 2012

  
• Pael-R, a substrate of Parkin, can also be cleared by PINK1

  Roberto Gavinio; Hodaka Yamakado; Tomoyo Sawada; Makio Takahashi; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2011

  
• Decreased anxiety-like behavior in alpha-synuclein BAC transgenic mice recapitulates early non-motor symptoms in Parkinson disease

  Hodaka Yamakado; Yasuhiro Moriwaki; Nobuyuki Yamasaki; Junko Kurisu; Tsuyoshi Miyakawa; Kengo Uemura; Haruhisa Inoue; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2011

  
• PaelR, a substrate of Parkin, can also be decreased by PINK1

  Roberto Gavinio; Hodaka Yamakado; Tomoyo Sawada; Akira Kuzuya; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2010

  
• PINK1 promotes the clearance of unfolded Pael-R in mammalian cell cultures

  Roberto Gavinio; Hodaka Yamakado; Tomoyo Sawada; Akira Kuzuya; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2009

  
• PARK4 mouse model

  Hodaka Yamakado; Yasuhiro Moriwaki; Jyunko Kurisu; Naoko Tsunekawa; Nobuyuki Yamasaki; Tsuyoshi Miyakawa; Kengo Uemura; Haruhisa Inoue; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2008

  

Presentations

• 神経変性疾患における中枢－末梢病態連関

  山門穂高

  第46回神経科学大会（シンポジウム）, 03 Aug. 2023

  
• パーキンソン病に伴う自律神経障害

  山門穂高

  第75回日本自律神経学会総会（シンポジウム）, 28 Oct. 2022

  
• Animal model for Parkinson's disease: Strengths and drawbacks

  山門穂高

  UK-Japan Neuroscience Symposium, 20 Sep. 2022

  
• 多系統萎縮症の病態はどこまで分かったか?

  山門穂高

  第16回MDSJ（教育講演）, 23 Jul. 2022

  
• Animal model of Parkinson's disease: For unveiling the pathogenesis and the develpment of DMT

  山門穂高

  第63回日本神経学会総会（シンポジウム）, 19 May 2022

  
• プロドローマル DLB/synucleinopathy - 動物モデルからみた prodromal synucleinopathy

  山門穂高

  第40回日本認知症学会（シンポジウム）, 27 Nov. 2021

  
• レヴィ小体病の病態と治療：update 2021 -シヌクレイノパチーの病態仮説とその前駆期動物モデルの作製

  山門穂高

  第39回日本神経治療学会（シンポジウム）, 28 Oct. 2021

  
• 神経変性疾患の新知見−未来に向けて 疾患修飾療法開発のための新しいパーキンソン病動物モデル

  山門穂高

  第44回日本神経科学大会 (シンポジウム）, 28 Jul. 2021

  
• Braakモデル再考 ーαシヌクレイン凝集体伝播に焦点を当てたアプローチー

  山門穂高

  MDSJ 2021（シンポジウム）, 02 Jul. 2021

  
• RBDを呈する新しい前駆期パーキンソン病モデルの開発

  山門穂高

  第62回 日本神経学会学術大会 (シンポジウム）, 19 May 2021

  
• 早期パーキンソン病のモデルの開発と治療の可能性

  山門穂高

  第38回日本神経治療学会学術集会（シンポジウム）, 30 Oct. 2020

  
• Animal model for disease-modifying therapies in Parkinson's disease

  Hodaka Yamakado

  第61回 日本神経学会学術大会 (シンポジウム）, 01 Sep. 2020

  
• パーキンソン病の前駆期症状を呈するマウスモデルの開発

  山門 穂高

  日本自律神経学会, 02 Nov. 2019

  
• Prodromal PD mice model

  Hodaka Yamakado

  Neuro2019 (Symposium), 27 Jul. 2019

  
• α-シヌクレイン凝集抑制治療は、 疾患修飾治療になりうるか？

  山門 穂高

  MDSJ 2019 (Controversy), 26 Jul. 2019

  

External funds: Kakenhi

• Investigation of the pathogenesis and the development of therapeutics of neurodegenerative disorders with cell-type specific liposome and exosome

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  山門 穂高

  From 30 Jul. 2020, To 31 Mar. 2023, Granted

  多系統萎縮症;シヌクレイン;エクソソーム;リポソーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21890/
• パーキンソン病関連疾患のモデル作製と治療薬開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52020:Neurology-related

  Kyoto University

  山門 穂高

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03590/
• Fundamental study on bioelectronic chip for diagnosis of pathologic conditions based on specific and ultrahighly sensitive detection of prion-like protein

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto Institute of Technology

  野田 実

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  診断チップ;プリオン様タンパク質;バイオセンサ;脂質膜;機械学習;パーキンソン病;αシヌクレイン;リポソーム;統計解析;診断用チップ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00663/
• A construction of new biosensor technology enabling highly sensitive detection of alpha-synuclein fibril originated from Parkinson's disease patient

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto Institute of Technology

  Minoru Noda

  From 28 Jun. 2019, To 31 Mar. 2022, Project Closed

  パーキンソン病;αシヌクレイン;リポソーム;脂質膜;カンチレバーセンサ;フィブリル;モノマー;糖脂質;オリゴマー;バイオセンサ;αーシヌクレイン;カンチレバー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22964/
• Pathogenesis and treatment of multiple system atrophy

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Hodaka Yamakado

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  多系統萎縮症;脳神経疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09672/
• Unveiling the Pathological Mechanisms and Developing New Treatment of Parkinsons Disease Caused by GBA1 Mutations

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Ryosuke Takahashi

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  パーキンソン病;αシヌクレイン;脂質;GBA1;メダカ;マウス;ゴーシェ病;脳神経疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02540/
• Investigating the pathomechanism underlying idiopathic Parkinson's disease using patient-derived iPS cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Hodaka Yamakado

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860666/
• Exploring the pathomechanism of Pakinson's disease by novel alpha-synuclein transgenic mice

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  HODAKA YAMAKADO

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790879/
• プルキンエ細胞およびバーグマングリア特異的Sept7欠損マウスの解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Nagoya University;Kyoto University

  木下 専

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  細胞骨格;ノックアウトマウス;微細形態;行動;神経変性疾患;膜骨格;拡散障壁;コンディショナルノックアウト;バーグマングリア;プルキンエ細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20022022/
• Elucidation of the pathogenesis and development of disease-modifying therapies targeting neurodegenerative disorders by proteolytic system

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  山門 穂高

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18575/
• Basic technology of lipid membrane immunosensor for detection of pathogenic protein in blood contributing to ultra-early diagnosis of dementia

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto Institute of Technology

  野田 実

  From 30 Jun. 2023, To 31 Mar. 2026, Granted

  認知症超早期診断;原因タンパク質;抗体様低分子;脂質膜;イムノセンサ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K17476/
• プリオン様タンパク質の凝集を起点としたパーキンソン病の診断と治療薬の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52020:Neurology-related

  Kyoto University

  山門 穂高

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02369/

Administration

Faculty management (title, position)

• From 01 Apr. 2013, To 31 Mar. 2014

  動物実験施設運営委員会
• From 01 Apr. 2014

  外来医長・看護師長会議 委員