Basic Information

Academic Degree

• 博士（医学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程脳統御医科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

High School

• High School

  三重高田高等学校

Research History

• From Oct. 2023, To Present

  京都大学大学院医学研究科多 系統萎縮症治療学講座, 特定准教授
• From Apr. 2019, To Sep. 2023

  京都大学医学部附属病院, 脳神経内科, 特定准教授
• From Apr. 2011, To Mar. 2019

  京都大学医学部附属病院, 神経内科, 助教
• From Jul. 2015, To Dec. 2016

  UC San Diego, Dept of Neurosciences, visiting scholar
• From Sep. 2010, To Mar. 2011

  医仁会武田総合病院, 神経内科, 医長
• From Apr. 2009, To Aug. 2010

  京都大学医学部附属病院, 神経内科, 助教
• From Apr. 2005, To Mar. 2009

  Kyoto University, Graduate School of Medicine, 大学院生
• From Apr. 2003, To Mar. 2005

  京都大学医学部附属病院, 神経内科, 医員
• From Apr. 2000, To Mar. 2003

  虎の門病院, 内科, 研修医

Language of Instruction

• Japanese

ID,URL

• J-Global ID

  201401015377937169

• Researcher number

  10378771

researchmap URL

• https://researchmap.jp/7000008893

Research

Research Topics, Overview of the research

• Research Topics

  Molecular biology of neurodegenerative disorders

• Overview of the research

  My research is fosused on the development of model for Parkinson's disease and multiple system atrophy using mice, rat, medaka fish and patients-derived iPS cells as well as investigation of pathomechanisms underlying PD and development of novel therapeutics for PD.

Research Interests

• プリオン
• α-シヌクレイン
• バイオマーカー
• 動物モデル
• 多系統萎縮症
• パーキンソン病

Research Areas

• Life sciences, Neurology

Papers

• 複視で発症したCreutzfeldt-Jakob病(CJD)の一例

  高橋 俊哉; 石本 智之; 山門 穂高; 葛谷 聡; 池田 昭夫; 高橋 良輔

  臨床神経学, Dec. 2018

  
• Evaluation of a commercial AI-assisted cell counting software for dopaminergic neurons across species

  Ken Kunugitani; Masanori Sawamura; Tomoyuki Taguchi; Tetsuya Hirato; Norihito Uemura; Takashi Ayaki; Etsuro Nakanishi; Hodaka Yamakado; Tomoyuki Ishimoto; Hirotaka Onoe; Tadashi Isa; Riki Matsumoto; Ryosuke Takahashi

  PLOS One, 17 Mar. 2026

  
• Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease

  Jun Ueda; Norihito Uemura; Jiarui Chang; Tetsuya Hirato; Tomoyuki Ishimoto; Miki Oono; Shuichi Matsuzawa; Riki Matsumoto; Hodaka Yamakado; Ryosuke Takahashi

  Movement Disorders, 08 Jan. 2026

  
• Highly sensitive detection of α-Synuclein in serum of Parkinson's disease patients by liposome-based sensor

  Kamitani Kotaro; Takahashi Yuya; Werner Carl Frederik; Sawamura Masanori; Yamamoto Hodaka; Sohgawa Masayuki; Noda Minoru

  JSAP Annual Meetings Extended Abstracts, 26 Aug. 2021

  
• Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson's disease.

  Asuka Morizane; Emi Yamasaki; Takero Shindo; Takayuki Anazawa; Nobukatsu Sawamoto; Atsushi Shima; Hodaka Yamakado; Etsuro Nakanishi; Masanori Sawamura; Yosuke Taruno; Daisuke Doi; Tetsuhiro Kikuchi; Yuri Kawasaki; Megumu K Saito; Takayuki Kikuchi; Yoshiki Arakawa; Susumu Miyamoto; Yuji Nakamoto; Ryosuke Takahashi; Jun Takahashi

  Cell stem cell, 04 Sep. 2025

  
• Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson's disease.

  Junichiro Ohira; Masanori Sawamura; Kenichi Kawano; Risa Sato; Tomoyuki Taguchi; Tomoyuki Ishimoto; Jun Ueda; Masashi Ikuno; Shu-Ichi Matsuzawa; Katsumi Matsuzaki; Ryosuke Takahashi; Hodaka Yamakado

  NPJ Parkinson's disease, 31 Jul. 2025

  
• Allogenic transplantation therapy of iPS cell-derived dopamine progenitors for Parkinson's disease -Current status of the Kyoto Trial and future perspectives.

  Ryosuke Takahashi; Etsuro Nakanishi; Hodaka Yamakado; Nobukatsu Sawamoto; Jun Takahashi

  Parkinsonism & related disorders, Jun. 2025

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• The Gut-Brain Axis Based on α-Synuclein Propagation-Clinical, Neuropathological, and Experimental Evidence.

  Ryosuke Takahashi; Hodaka Yamakado; Norihito Uemura; Tomoyuki Taguchi; Jun Ueda

  International journal of molecular sciences, 23 Apr. 2025

  
• Expectations regarding regenerative medicine and attitudes toward invasive surgical therapies in patients with Parkinson's disease: A cross-sectional survey.

  Mika Watabe; Atsushi Shima; Kiyoaki Takeda; Yuta Terada; Yusuke Sakato; Akira Nishida; Ikko Wada; Haruhi Sakamaki-Tsukita; Kenji Yoshimura; Daisuke Kambe; Koji Furukawa; Masanori Sawamura; Etsuro Nakanishi; Yosuke Taruno; Hodaka Yamakado; Ryosuke Takahashi; Nobukatsu Sawamoto

  Clinical parkinsonism & related disorders, 2025

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• Enhanced alpha-synuclein pathology and exacerbated motor dysfunction in alpha-synuclein transgenic mice with autophagy deficiency.

  Sachiko Noda; Shigeto Sato; Hodaka Yamakado; Ryosuke Takahashi; Nobutaka Hattori

  Biochemical and biophysical research communications, 19 Feb. 2025

  
• A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson’s disease

  Mitsuaki Kashiwagi; Goichi Beck; Mika Kanuka; Yoshifumi Arai; Kaeko Tanaka; Chika Tatsuzawa; Yumiko Koga; Yuki C. Saito; Marina Takagi; Yo Oishi; Masanori Sakaguchi; Kousuke Baba; Masashi Ikuno; Hodaka Yamakado; Ryosuke Takahashi; Masashi Yanagisawa; Shigeo Murayama; Takeshi Sakurai; Kazuya Sakai; Yoshimi Nakagawa; Masahiko Watanabe; Hideki Mochizuki; Yu Hayashi

  Cell, Sep. 2024

  
• Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson's disease.

  Nobukatsu Sawamoto; Daisuke Doi; Etsuro Nakanishi; Masanori Sawamura; Takayuki Kikuchi; Hodaka Yamakado; Yosuke Taruno; Atsushi Shima; Yasutaka Fushimi; Tomohisa Okada; Tetsuhiro Kikuchi; Asuka Morizane; Satoe Hiramatsu; Takayuki Anazawa; Takero Shindo; Kentaro Ueno; Satoshi Morita; Yoshiki Arakawa; Yuji Nakamoto; Susumu Miyamoto; Ryosuke Takahashi; Jun Takahashi

  Nature, 16 Apr. 2025

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• αシヌクレイン伝播モデルマウスにおける睡眠構造の変化について

  江川 斉宏; 奥田 真也; 原 淳子; 上村 紀仁; 生野 真嗣; 山門 穂高; 高橋 良輔

  日本睡眠学会定期学術集会プログラム・抄録集, Jun. 2019

  
• Involvement of the basal forebrain and hippocampus in memory deficits in Parkinson's disease.

  Haruhi Sakamaki-Tsukita; Atsushi Shima; Daisuke Kambe; Koji Furukawa; Akira Nishida; Ikko Wada; Kenji Yoshimura; Yusuke Sakato; Yuta Terada; Hodaka Yamakado; Yosuke Taruno; Etsuro Nakanishi; Masanori Sawamura; Yasutaka Fushimi; Tomohisa Okada; Yuji Nakamoto; Laszlo Zaborszky; Ryosuke Takahashi; Nobukatsu Sawamoto

  Parkinsonism & related disorders, Nov. 2024

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• Neural substrates underlying distinct dual cognitive syndromes in Parkinson's disease.

  Kenji Yoshimura; Atsushi Shima; Daisuke Kambe; Koji Furukawa; Akira Nishida; Ikko Wada; Yusuke Sakato; Haruhi Sakamaki-Tsukita; Yuta Terada; Hodaka Yamakado; Yosuke Taruno; Etsuro Nakanishi; Masanori Sawamura; Koji Fujimoto; Yasutaka Fushimi; Tomohisa Okada; Yuji Nakamoto; Takashi Hanakawa; Ryosuke Takahashi; Nobukatsu Sawamoto

  European journal of neurology, Jan. 2025, Peer-reviewed

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• A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy.

  Masanori Sawamura; Kiyoshi Tachikawa; Rie Hikawa; Hisako Akiyama; Seiji Kaji; Ken Yasuda; Angel I Leu; Hyojung Hong; Rajesh Mukthavaram; Pad Chivukula; Hodaka Yamakado; Yoshio Hirabayashi; Ryosuke Takahashi; Shu-Ichi Matsuzawa

  Molecular therapy. Nucleic acids, 10 Dec. 2024

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• Delineating three distinct spatiotemporal patterns of brain atrophy in Parkinson's disease.

  Yusuke Sakato; Atsushi Shima; Yuta Terada; Kiyoaki Takeda; Haruhi Sakamaki-Tsukita; Akira Nishida; Kenji Yoshimura; Ikko Wada; Koji Furukawa; Daisuke Kambe; Hiroki Togo; Yohei Mukai; Masanori Sawamura; Etsuro Nakanishi; Hodaka Yamakado; Yasutaka Fushimi; Tomohisa Okada; Yuji Takahashi; Yuji Nakamoto; Ryosuke Takahashi; Takashi Hanakawa; Nobukatsu Sawamoto

  Brain : a journal of neurology, 24 Oct. 2024

  
• Frontoparietal-Striatal Network and Nucleus Basalis Modulation in Patients With Parkinson Disease and Gait Disturbance.

  Akira Nishida; Atsushi Shima; Daisuke Kambe; Koji Furukawa; Haruhi Sakamaki-Tsukita; Kenji Yoshimura; Ikko Wada; Yusuke Sakato; Yuta Terada; Masanori Sawamura; Etsuro Nakanishi; Yosuke Taruno; Hodaka Yamakado; Yasutaka Fushimi; Tomohisa Okada; Yuji Nakamoto; Ryosuke Takahashi; Nobukatsu Sawamoto

  Neurology, 13 Aug. 2024

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• A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

  Tomoyuki Ishimoto; Miki Oono; Seiji Kaji; Takashi Ayaki; Katsuya Nishida; Itaru Funakawa; Takakuni Maki; Shu-ichi Matsuzawa; Ryosuke Takahashi; Hodaka Yamakado

  Molecular Brain, 24 May 2024

  
• Experimental Animal Models of Prodromal Parkinson's Disease.

  Hodaka Yamakado; Ryosuke Takahashi

  Journal of Parkinson's disease, 24 Feb. 2024

  
• 亜急性発症のミオクロニーてんかんの一例

  十河 正弥; 戸島 麻耶; 錦織 隆成; 濱口 敏和; 下竹 昭寛; 木村 公俊; 岡田 信久; 當間 圭一郎; 眞木 崇州; 山門 穂高; 高橋 良輔; 池田 昭夫

  てんかん研究, Sep. 2019

  
• A Rapid, Sensitive, and Specific Detection of Aggregated α-Synuclein by a Liposome-Immobilized Cantilever Sensor

  Ryoko Kobayashi; Kotaro Kamitani; Masanori Sawamura; Hodaka Yamakado; Ryosuke Takahashi; Masayuki Sohgawa; Minoru Noda

  IEEE Sensors Journal, 15 Jun. 2023, Peer-reviewed

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• Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs.

  Masanori Sawamura; Junichiro Ohira; Rie Hikawa; Tomoyuki Ishimoto; Etsuro Nakanishi; Hodaka Yamakado; Ryosuke Takahashi

  Parkinsonism & related disorders, 20 May 2023

  
• A RaPID Macrocyclic Peptide That Inhibits the Formation of α-Synuclein Amyloid Fibrils.

  Tatsuya Ikenoue; Miki Oono; Masatomo So; Hodaka Yamakado; Toshiaki Arata; Ryosuke Takahashi; Yasushi Kawata; Hiroaki Suga

  Chembiochem : a European journal of chemical biology, 25 Apr. 2023

  
• Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission.

  Jun Ueda; Norihito Uemura; Tomoyuki Ishimoto; Tomoyuki Taguchi; Masanori Sawamura; Etsuro Nakanishi; Masashi Ikuno; Shuichi Matsuzawa; Hodaka Yamakado; Ryosuke Takahashi

  Movement disorders, 17 Apr. 2023

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• 抗ミトコンドリア抗体陽性筋炎で下肢MRIに大内転筋に特徴的なSTIR高信号を認めた3例

  上田 紗希帆; 南山 素三雄; 山門 穂高; 山下 博史; 中嶋 蘭; 細川 祐司; 山川 範之; 湯川 尚一郎; 澤本 伸克; 漆谷 真; 三森 経世; 高橋 良輔

  臨床神経学, Dec. 2014

  
• DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers.

  Mingyue Jin; Sakiko Matsumoto; Takashi Ayaki; Hodaka Yamakado; Tomoyuki Taguchi; Natsuko Togawa; Ayumu Konno; Hirokazu Hirai; Hiroshi Nakajima; Shoji Komai; Ryuichi Ishida; Syuhei Chiba; Ryosuke Takahashi; Toshifumi Takao; Shinji Hirotsune

  Nature communications, 12 Nov. 2022

  
• Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice.

  Shinya Okuda; Takeo Nakayama; Norihito Uemura; Rie Hikawa; Masashi Ikuno; Hodaka Yamakado; Haruhisa Inoue; Naoko Tachibana; Yu Hayashi; Ryosuke Takahashi; Naohiro Egawa

  International journal of molecular sciences, 02 Nov. 2022

  
• Lewy Body Disease Primate Model with α-Synuclein Propagation from the Olfactory Bulb.

  Masanori Sawamura; Hirotaka Onoe; Hideo Tsukada; Kaoru Isa; Hodaka Yamakado; Shinya Okuda; Masashi Ikuno; Yusuke Hatanaka; Shigeo Murayama; Norihito Uemura; Tadashi Isa; Ryosuke Takahashi

  Movement disorders, 21 Aug. 2022

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• Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation.

  Masanori Sawamura; Keiko Imamura; Rie Hikawa; Takako Enami; Ayako Nagahashi; Hodaka Yamakado; Hidenori Ichijo; Takao Fujisawa; Hirofumi Yamashita; Sumio Minamiyama; Misako Kaido; Hiromi Wada; Makoto Urushitani; Haruhisa Inoue; Naohiro Egawa; Ryosuke Takahashi

  Scientific reports, 25 Jul. 2022

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• An ultrasensitive detection of aggregated α-synuclein as a biomarker molecule for Parkinson disease by liposome-immobilized cantilever biosensor using self-templating phenomena of prionoid protein

  Ryoko Kobayashi; Masanori Sawamura; Hodaka Yamakado; Masayuki Sohgawa; Minoru Noda

  MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2020

  
• A New Detection of Biomarker Molecule of α-Synuclein for Parkinson Disease by Phospholipid Liposome-Immobilized Cantilever Microsensor with Temperature Stabilization

  Ryoko Kobayashi; Masanori Sawamura; Hodaka Yamakado; Masayuki Sohgawa; Minoru Noda

  2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Jun. 2019

  
• Periodic alternating gaze deviationを認めた原因不明の脳症の1症例

  大井 長和; 林 紗葵; 佐藤 啓; 真田 悠希; 長谷川 華子; 濱口 敏和; 眞木 崇州; 山門 穂高; 葛谷 聡; 松本 理器; 池田 昭夫; 高橋 良輔

  神経眼科, Nov. 2018, Peer-reviewed

  
• GBA2は神経型ゴーシェ病/GBA関連パーキンソン病の新たな修飾因子となりうるか

  中西 悦郎; 上村 紀仁; 秋山 央子; 木下 政人; 山門 穂高; 武田 俊一; 平林 義雄; 高橋 良輔

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, Jul. 2018, Peer-reviewed

  
• 神経型ゴーシェ病モデルメダカの病態におけるGBA2の役割

  中西 悦郎; 上村 紀仁; 秋山 央子; 木下 政人; 山門 穂高; 武田 俊一; 平林 義雄; 高橋 良輔

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, Oct. 2015, Peer-reviewed

  
• Motor progression and nigrostriatal neurodegeneration in Parkinson's disease.

  Koji Furukawa; Atsushi Shima; Daisuke Kambe; Akira Nishida; Ikko Wada; Haruhi Sakamaki; Kenji Yoshimura; Yuta Terada; Yusuke Sakato; Masahiro Mitsuhashi; Masanori Sawamura; Etsuro Nakanishi; Yosuke Taruno; Hodaka Yamakado; Yasutaka Fushimi; Tomohisa Okada; Yuji Nakamoto; Ryosuke Takahashi; Nobukatsu Sawamoto

  Annals of neurology, 15 Apr. 2022

  
• Rapid Induction of Dopaminergic Neuron Loss Accompanied by Lewy Body-Like Inclusions in A53T BAC-SNCA Transgenic Mice

  Shinya Okuda; Norihito Uemura; Masanori Sawamura; Tomoyuki Taguchi; Masashi Ikuno; Maiko T. Uemura; Hodaka Yamakado; Ryosuke Takahashi

  Neurotherapeutics, 21 Dec. 2021, Peer-reviewed

  
• Mitochondrial dysfunction in a mouse model of prodromal Parkinson's disease: A metabolomic analysis.

  Masashi Ikuno; Hodaka Yamakado; Ikuko Amano; Yusuke Hatanaka; Norihito Uemura; Shu-Ichi Matsuzawa; Ryosuke Takahashi

  Neuroscience letters, 24 Sep. 2021, Peer-reviewed, Corresponding author

  
• Membranes and Organelle in Lewy Bodies: The Mastermind or the Bystander?

  Tomoyuki Ishimoto; Hodaka Yamakado

  Movement disorders, Sep. 2021, Peer-reviewed, Last author, Corresponding author

  
• The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy.

  Yutaka Inoue; Takashi Ayaki; Tomoyuki Ishimoto; Hodaka Yamakado; Takakuni Maki; Shuichi Matsuzawa; Nobukatsu Sawamoto; Ryosuke Takahashi

  Neuroscience letters, 24 May 2021, Peer-reviewed

  
• Impact of Gba2 on neuronopathic Gaucher's disease and α-synuclein accumulation in medaka (Oryzias latipes).

  Etsuro Nakanishi; Norihito Uemura; Hisako Akiyama; Masato Kinoshita; Sawamura Masanori; Yosuke Taruno; Hodaka Yamakado; Shu-Ichi Matsuzawa; Shunichi Takeda; Yoshio Hirabayashi; Ryosuke Takahashi

  Molecular brain, 10 May 2021, Peer-reviewed

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• Perampanel Inhibits α-Synuclein Transmission in Parkinson's Disease Models.

  Jun Ueda; Norihito Uemura; Masanori Sawamura; Tomoyuki Taguchi; Masashi Ikuno; Seiji Kaji; Yosuke Taruno; Shuichi Matsuzawa; Hodaka Yamakado; Ryosuke Takahashi

  Movement disorders, 04 Apr. 2021, Peer-reviewed

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• α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.

  Norihito Uemura; Jun Ueda; Toru Yoshihara; Masashi Ikuno; Maiko T Uemura; Hodaka Yamakado; Masahide Asano; John Q Trojanowski; Ryosuke Takahashi

  Movement disorders, 06 Feb. 2021, Peer-reviewed

  
• Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks

  M. Asada-Utsugi; K. Uemura; M. Kubota; Y. Noda; Y. Tashiro; T. M. Uemura; H. Yamakado; M. Urushitani; R. Takahashi; S. Hattori; T. Miyakawa; N. Ageta-Ishihara; K. Kobayashi; M. Kinoshita; A. Kinoshita

  Molecular Brain, Jan. 2021, Peer-reviewed

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• BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy.

  Seiji Kaji; Takakuni Maki; Jun Ueda; Tomoyuki Ishimoto; Yutaka Inoue; Ken Yasuda; Masanori Sawamura; Rie Hikawa; Takashi Ayaki; Hodaka Yamakado; Ryosuke Takahashi

  Acta neuropathologica communications, 29 Jul. 2020, Peer-reviewed

  
• Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

  Laxmi Kumar Parajuli; Ken Wako; Suiki Maruo; Soichiro Kakuta; Tomoyuki Taguchi; Masashi Ikuno; Hodaka Yamakado; Ryosuke Takahashi; Masato Koike

  eneuro, Jul. 2020, Peer-reviewed

  
• Susceptibility to erastin-induced ferroptosis decreases during maturation in a human oligodendrocyte cell line.

  Tomonori Hoshino; Hodaka Yamakado; Ryosuke Takahashi; Shu-Ichi Matsuzawa

  FEBS open bio, 01 Jul. 2020, Peer-reviewed

  
• Reduced Enhancement of Memory for Faces Encoded by Semantic and Socioemotional Processes in Patients with Parkinson's Disease.

  Paeksoon Park; Hodaka Yamakado; Ryosuke Takahashi; Shikiho Dote; Shiho Ubukata; Toshiya Murai; Takashi Tsukiura

  Journal of the International Neuropsychological Society : JINS, Apr. 2020, Peer-reviewed

  
• Animal Model for Prodromal Parkinson's Disease.

  Tomoyuki Taguchi; Masashi Ikuno; Hodaka Yamakado; Ryosuke Takahashi

  International journal of molecular sciences, 13 Mar. 2020, Peer-reviewed, Corresponding author

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• Limited spread of pathology within the brainstem of α-synuclein BAC transgenic mice inoculated with preformed fibrils into the gastrointestinal tract.

  Norihito Uemura; Hisashi Yagi; Maiko T Uemura; Hodaka Yamakado; Ryosuke Takahashi

  Neuroscience letters, 18 Jan. 2020, Peer-reviewed

  
• Thigh muscle MRI findings in myopathy associated with anti-mitochondrial antibody.

  Sumio Minamiyama; Sakiho Ueda; Ran Nakashima; Hodaka Yamakado; Yusuke Sakato; Hirofumi Yamashita; Nobukatsu Sawamoto; Ryota Fujimoto; Ichizo Nishino; Makoto Urushitani; Tsuneyo Mimori; Ryosuke Takahashi

  Muscle & nerve, Jan. 2020, Peer-reviewed, Corresponding author

  
• Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions.

  Seiji Kaji; Takakuni Maki; Tomoyuki Ishimoto; Hodaka Yamakado; Ryosuke Takahashi

  Translational neurodegeneration, 2020, Peer-reviewed

  
• α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson's disease model.

  Tomoyuki Taguchi; Masashi Ikuno; Mari Hondo; Laxmi Kumar Parajuli; Katsutoshi Taguchi; Jun Ueda; Masanori Sawamura; Shinya Okuda; Etsuro Nakanishi; Junko Hara; Norihito Uemura; Yusuke Hatanaka; Takashi Ayaki; Shuichi Matsuzawa; Masaki Tanaka; Omar M A El-Agnaf; Masato Koike; Masashi Yanagisawa; Maiko T Uemura; Hodaka Yamakado; Ryosuke Takahashi

  Brain : a journal of neurology, 01 Jan. 2020, Peer-reviewed, Corresponding author

  
• TPPP/p25α Is an old and new therapeutic target in multiple system atrophy.

  Ishimoto T; Yamakado H

  Movement disorders, Nov. 2019, Peer-reviewed

  
• Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.

  Norihito Uemura; Hisashi Yagi; Maiko T Uemura; Yusuke Hatanaka; Hodaka Yamakado; Ryosuke Takahashi

  Molecular neurodegeneration, 26 Jul. 2019, Peer-reviewed

  
• GBA haploinsufficiency accelerates alpha-synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease.

  Masashi Ikuno; Hodaka Yamakado; Hisako Akiyama; Laxmi Kumar Parajuli; Katsutoshi Taguchi; Junko Hara; Norihito Uemura; Yusuke Hatanaka; Katsumi Higaki; Kousaku Ohno; Masaki Tanaka; Masato Koike; Yoshio Hirabayashi; Ryosuke Takahashi

  Human molecular genetics, 01 Jun. 2019, Peer-reviewed, Corresponding author

  
• Homozygous 31 trinucleotide repeats in the SCA2 allele are pathogenic for cerebellar ataxia.

  Tojima M; Murakami G; Hikawa R; Yamakado H; Yamashita H; Takahashi R; Matsui M

  Neurology. Genetics, Dec. 2018, Peer-reviewed

  
• Ischemic Fasciitis of the Left Buttock in a 40-Year-Old Woman with Beta-Propeller Protein-Associated Neurodegeneration (BPAN)

  Akio Sakamoto; Ryuzo Arai; Takeshi Okamoto; Yosuke Yamada; Hodaka Yamakado; Shuichi Matsuda

  American Journal of Case Reports, 20 Oct. 2018, Peer-reviewed

  
• Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation.

  Kim C; Spencer B; Rockenstein E; Yamakado H; Mante M; Adame A; Fields JA; Masliah D; Iba M; Lee HJ; Rissman RA; Lee SJ; Masliah E

  Molecular neurodegeneration, Aug. 2018, Peer-reviewed

  
• Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology.

  Fujita K; Homma H; Kondo K; Ikuno M; Yamakado H; Tagawa K; Murayama S; Takahashi R; Okazawa H

  eNeuro, Jul. 2018, Peer-reviewed

  
• Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve.

  Uemura N; Yagi H; Uemura MT; Hatanaka Y; Yamakado H; Takahashi R

  Molecular neurodegeneration, May 2018, Peer-reviewed

  
• Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl.

  Hikiami R; Yamakado H; Tatsumi S; Ayaki T; Hashi Y; Yamashita H; Sawamoto N; Tsuji T; Urushitani M; Takahashi R

  Internal medicine, Feb. 2018, Peer-reviewed, Corresponding author

  
• Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity

  Maiko T. Uemura; Takeshi Asano; Rie Hikawa; Hodaka Yamakado; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, Nov. 2017, Peer-reviewed, Corresponding author

  
• Idiopathic Parkinson's Disease Patient-derived Induced Pluripotent Stem Cells Function as Midbrain Dopaminergic Neurons in Rodent Brains

  Tetsuhiro Kikuchi; Asuka Morizane; Daisuke Doi; Keisuke Okita; Masato Nakagawa; Hodaka Yamakado; Haruhisa Inoue; Ryosuke Takahashi; Jun Takahashi

  JOURNAL OF NEUROSCIENCE RESEARCH, Sep. 2017, Peer-reviewed

  
• Altered awareness of action in Parkinson's disease: evaluations by explicit and implicit measures

  Naho Saito; Keisuke Takahata; Hodaka Yamakado; Nobukatsu Sawamoto; Satoshi Saito; Ryosuke Takahashi; Toshiya Murai; Hidehiko Takahashi

  SCIENTIFIC REPORTS, Aug. 2017, Peer-reviewed

  Access this paper :

  
• Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

  Elisabet Ihse; Hodaka Yamakado; Xander M. van Wijk; Roger Lawrence; Jeffrey D. Esko; Eliezer Masliah

  SCIENTIFIC REPORTS, Aug. 2017, Peer-reviewed

  
• Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases

  Hisanori Kinoshita; Hodaka Yamakado; Toshiyuki Kitano; Akihiro Kitamura; Hirofumi Yamashita; Masakazu Miyamoto; Takefumi Hitomi; Tomohisa Okada; Yuji Nakamoto; Nobukatsu Sawamoto; Akifumi Takaori-Kondo; Ryosuke Takahashi

  JOURNAL OF NEUROLOGY, Sep. 2016, Peer-reviewed, Corresponding author

  
• A case of variant biochemical phenotype of Niemann-Pick disease type C accompanying savant syndrome

  Mio Hamatani; Naoto Jingami; Kengo Uemura; Naoe Nakasone; Hisanori Kinoshita; Hodaka Yamakado; Haruaki Ninomiya; Ryosuke Takahashi

  Clinical Neurology, 2016, Peer-reviewed

  
• 精神症状で発症した再発性多発軟骨炎に脳炎を合併した一例

  前川 嵩太; 引網 亮太; 上田 紗希帆; 三嶋 亮; 狭間 雅章; 山門 穂高; 澤本 伸克; 漆谷 真; 高橋 良輔

  臨床神経学, Aug. 2015

  
• Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein

  Norihito Uemura; Masato Koike; Satoshi Ansai; Masato Kinoshita; Tomoko Ishikawa-Fujiwara; Hideaki Matsui; Kiyoshi Naruse; Naoaki Sakamoto; Yasuo Uchiyama; Takeshi Todo; Shunichi Takeda; Hodaka Yamakado; Ryosuke Takahashi

  PLOS GENETICS, Apr. 2015, Peer-reviewed

  Access this paper :

  
• Advance in PD Research Explored a New Field on Ubiquitin Biology

  Hodaka Yamakado

  MOVEMENT DISORDERS, Sep. 2014, Peer-reviewed

  
• Exploring the Pathogenetic Mechanisms underlying Parkinson's Disease in Medaka Fish

  Hideaki Matsui; Norihito Uemura; Hodaka Yamakado; Shunichi Takeda; Ryosuke Takahashi

  JOURNAL OF PARKINSONS DISEASE, 2014, Peer-reviewed

  
• Two cases of acute onset of focal cortical reflex myoclonus following acute aseptic meningoencephalitis with positive anti-glutamate receptor autoantibody

  Maya Tojima; Takefumi Hitomi; Naoto Jingami; Kosuke Tanioka; Hodaka Yamakado; Riki Matsumoto; Yukitoshi Takahashi; Akio Ikeda; Ryosuke Takahashi

  Clinical Neurology, 2014, Peer-reviewed

  
• Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction

  Eiko N. Minakawa; Hodaka Yamakado; Atsushi Tanaka; Kengo Uemura; Shunichi Takeda; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, Dec. 2013, Peer-reviewed

  
• Genetic correction will be a standard method for the patient-derived ips cell research?

  Ryosuke Takahashi; Hodaka Yamakado

  Movement Disorders, Dec. 2013, Peer-reviewed

  
• The Function of Parkin: Revisited

  Hodaka Yamakado; Ryosuke Takahashi

  MOVEMENT DISORDERS, Dec. 2013, Peer-reviewed

  
• 縦隔リンパ節の小細胞癌によるParaneoplastic extralimbic and limbic encephalitisを呈した1剖検例

  南山 素三雄; 上田 紗希帆; 濱谷 美緒; 綾木 孝; 山門 穂高; 竹内 康英; 池本 明人; 伊東 秀文; 澤本 伸克; 高橋 良輔

  神経免疫学, Nov. 2013

  
• Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice

  Natsumi Ageta-Ishihara; Hodaka Yamakado; Takao Morita; Satoko Hattori; Keizo Takao; Tsuyoshi Miyakawa; Ryosuke Takahashi; Makoto Kinoshita

  MOLECULAR BRAIN, Aug. 2013, Peer-reviewed

  
• PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates

  Hideaki Matsui; Roberto Gavinio; Takeshi Asano; Norihito Uemura; Hidefumi Ito; Yoshihito Taniguchi; Yoshito Kobayashi; Takakuni Maki; Jie Shen; Shunichi Takeda; Kengo Uemura; Hodaka Yamakado; Ryosuke Takahashi

  HUMAN MOLECULAR GENETICS, Jun. 2013, Peer-reviewed

  
• A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

  Silke Nuber; Florian Harmuth; Zacharias Kohl; Anthony Adame; Margaritha Trejo; Kai Schönig; Frank Zimmermann; Claudia Bauer; Nicolas Casadei; Christiane Giel; Carsten Calaminus; Bernd J. Pichler; Poul H. Jensen; Christian P. Müller; Davide Amato; Johannes Kornhuber; Peter Teismann; Hodaka Yamakado; Ryosuke Takahashi; Juergen Winkler; Eliezer Masliah; Olaf Riess

  Brain, 2013, Peer-reviewed

  
• Horner症候群が局在診断に役立ったTolosa-Hunt症候群の1例

  南山 素三雄; 陣上 直人; 山門 穂高; 猪原 匡史; 高橋 良輔

  自律神経, Jun. 2012

  
• alpha-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion

  Hodaka Yamakado; Yasuhiro Moriwaki; Nobuyuki Yamasaki; Tsuyoshi Miyakawa; Junko Kurisu; Kengo Uemura; Haruhisa Inoue; Makio Takahashi; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, Jun. 2012, Peer-reviewed

  
• Unverricht-Lundborg disease manifesting tremulous myoclonus with rare convulsive seizures: A case report

  Takayuki Kondo; Hodaka Yamakado; Jun Kawamata; Hidekazu Tomimoto; Takefumi Hitomi; Ryosuke Takahashi; Akio Ikeda

  Clinical Neurology, 2009, Peer-reviewed

  
• Cocaine and phenylephrine eye drop test for Parkinson disease

  H Sawada; K Yamakawa; H Yamakado; R Hosokawa; M Ohba; K Miyamoto; T Kawamura; S Shimohama

  JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Feb. 2005, Peer-reviewed

  

Misc.

• 嗅球体積及びMIBG心筋シンチグラフィによるパーキンソン病の特性評価

  島淳; 島淳; 和田一孝; 寺田祐太; 坂戸勇介; 酒巻春日; 西田聖; 吉村賢二; 武田清明; 菊谷明広; 澤村正典; 中西悦郎; 山門穂高; 伏見育崇; 高橋良輔; 高橋良輔; 澤本伸克; 澤本伸克

  日本自律神経学会総会プログラム・抄録集, 2024

  
• パーキンソン病におけるドパミン神経変性の非対称性と自律神経障害に関する検討

  寺田祐太; 島淳; 島淳; 酒井遼介; 吉田紀子; 武田清明; 坂戸勇介; 酒巻春日; 西田聖; 吉村賢二; 和田一孝; 澤村正典; 中西悦郎; 山門穂高; 高橋良輔; 澤本伸克

  日本自律神経学会総会プログラム・抄録集, 2024

  
• Is the GBA2 a new modifier for Gauchers's disease and GBA1-related Parkinson's disease?

  E. Nakanishi; N. Uemura; H. Akiyama; M. Kinoshita; H. Yamakado; S. Takeda; Y. Hirabayashi; R. Takahashi

  MOVEMENT DISORDERS, Jun. 2017

  
• FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像：若年発症例を含む4症例の検討

  引網亮太; 端祐一郎; 山門穂高; 辰己新水; 山下博史; 澤本伸克; 辻輝 之; 川本未知; 幸原伸夫; 井上治久; 漆谷真; 高橋良輔

  56th Annual Meeting of the Japanese Society of Neurology, Niigata., 21 May 2015

  
• iPS cell modeling of genetic Parkinson's disease

  Yasushi Koshiba; Hodaka Yamakado; Asuka Morizane; Tetsuhiro Kikuchi; Kazuko Hasegawa; Haruhisa Inoue; Jun Takahashi; Ryosuke Takahashi

  MOVEMENT DISORDERS, Nov. 2014

  
• Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain

  N. Uemura; H. Matsui; T. Fujiwara-Ishikawa; M. Kinoshita; M. Koike; H. Yamakado; K. Uemura; Y. Uchiyama; T. Todo; S. I. Takeda; R. Takahashi

  MOVEMENT DISORDERS, Jun. 2013

  
• alpha-synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior

  H. Yamakado; Y. Moriwaki; N. Yamasaki; T. Miyakawa; J. Kurisu; K. Uemura; H. Inoue; M. Takahashi; R. Takahashi

  MOVEMENT DISORDERS, Jun. 2012

  
• Pael-R, a substrate of Parkin, can also be cleared by PINK1

  Roberto Gavinio; Hodaka Yamakado; Tomoyo Sawada; Makio Takahashi; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2011

  
• Decreased anxiety-like behavior in alpha-synuclein BAC transgenic mice recapitulates early non-motor symptoms in Parkinson disease

  Hodaka Yamakado; Yasuhiro Moriwaki; Nobuyuki Yamasaki; Junko Kurisu; Tsuyoshi Miyakawa; Kengo Uemura; Haruhisa Inoue; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2011

  
• PaelR, a substrate of Parkin, can also be decreased by PINK1

  Roberto Gavinio; Hodaka Yamakado; Tomoyo Sawada; Akira Kuzuya; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2010

  
• PINK1 promotes the clearance of unfolded Pael-R in mammalian cell cultures

  Roberto Gavinio; Hodaka Yamakado; Tomoyo Sawada; Akira Kuzuya; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2009

  
• PARK4 mouse model

  Hodaka Yamakado; Yasuhiro Moriwaki; Jyunko Kurisu; Naoko Tsunekawa; Nobuyuki Yamasaki; Tsuyoshi Miyakawa; Kengo Uemura; Haruhisa Inoue; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2008

  

Presentations

• 神経変性疾患における中枢－末梢病態連関

  山門穂高

  第46回神経科学大会（シンポジウム）, 03 Aug. 2023

  
• パーキンソン病に伴う自律神経障害

  山門穂高

  第75回日本自律神経学会総会（シンポジウム）, 28 Oct. 2022

  
• Animal model for Parkinson's disease: Strengths and drawbacks

  山門穂高

  UK-Japan Neuroscience Symposium, 20 Sep. 2022

  
• 多系統萎縮症の病態はどこまで分かったか?

  山門穂高

  第16回MDSJ（教育講演）, 23 Jul. 2022

  
• Animal model of Parkinson's disease: For unveiling the pathogenesis and the develpment of DMT

  山門穂高

  第63回日本神経学会総会（シンポジウム）, 19 May 2022

  
• プロドローマル DLB/synucleinopathy - 動物モデルからみた prodromal synucleinopathy

  山門穂高

  第40回日本認知症学会（シンポジウム）, 27 Nov. 2021

  
• レヴィ小体病の病態と治療：update 2021 -シヌクレイノパチーの病態仮説とその前駆期動物モデルの作製

  山門穂高

  第39回日本神経治療学会（シンポジウム）, 28 Oct. 2021

  
• 神経変性疾患の新知見−未来に向けて 疾患修飾療法開発のための新しいパーキンソン病動物モデル

  山門穂高

  第44回日本神経科学大会 (シンポジウム）, 28 Jul. 2021

  
• Braakモデル再考 ーαシヌクレイン凝集体伝播に焦点を当てたアプローチー

  山門穂高

  MDSJ 2021（シンポジウム）, 02 Jul. 2021

  
• RBDを呈する新しい前駆期パーキンソン病モデルの開発

  山門穂高

  第62回 日本神経学会学術大会 (シンポジウム）, 19 May 2021

  
• 早期パーキンソン病のモデルの開発と治療の可能性

  山門穂高

  第38回日本神経治療学会学術集会（シンポジウム）, 30 Oct. 2020

  
• Animal model for disease-modifying therapies in Parkinson's disease

  Hodaka Yamakado

  第61回 日本神経学会学術大会 (シンポジウム）, 01 Sep. 2020

  
• パーキンソン病の前駆期症状を呈するマウスモデルの開発

  山門 穂高

  日本自律神経学会, 02 Nov. 2019

  
• Prodromal PD mice model

  Hodaka Yamakado

  Neuro2019 (Symposium), 27 Jul. 2019

  
• α-シヌクレイン凝集抑制治療は、 疾患修飾治療になりうるか？

  山門 穂高

  MDSJ 2019 (Controversy), 26 Jul. 2019

  

External funds: Kakenhi

• 頭部上下動の脳内炎症・酸化ストレス抑制効果に基づくパーキンソン病新規治療法の開発

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields

  Institute of Science Tokyo

  澤田 泰宏

  From 26 Jun. 2026, To 31 Mar. 2028, Granted

  力学的刺激（メカニカルストレス）;運動模倣介入;生体恒常性維持;パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K23747/
• 神経変性疾患に対する強化免疫療法の試み

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  山門 穂高

  From 26 Jun. 2026, To 31 Mar. 2029, Granted

  多系統萎縮症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K23464/
• Investigation of the pathogenesis and the development of therapeutics of neurodegenerative disorders with cell-type specific liposome and exosome

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  Hodaka Yamakado

  From 30 Jul. 2020, To 31 Mar. 2025, Project Closed

  オリゴデンドロサイト;Krabbe病;リポソーム;多系統萎縮症;シヌクレイン;エクソソーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21890/
• Modeling and Drug Development for Parkinsons Disease and Related Disorders

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52020:Neurology-related

  Kyoto University

  Hodaka Yamakado

  From 01 Apr. 2020, To 31 Mar. 2024, Project Closed

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03590/
• Fundamental study on bioelectronic chip for diagnosis of pathologic conditions based on specific and ultrahighly sensitive detection of prion-like protein

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto Institute of Technology

  Minoru Noda

  From 01 Apr. 2020, To 31 Mar. 2024, Project Closed

  診断用チップ;プリオン様タンパク質;バイオセンサ;脂質膜;αシヌクレイン;リポソーム;アミロイドβ;統計解析;診断チップ;機械学習;パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00663/
• A construction of new biosensor technology enabling highly sensitive detection of alpha-synuclein fibril originated from Parkinson's disease patient

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto Institute of Technology

  Minoru Noda

  From 28 Jun. 2019, To 31 Mar. 2022, Project Closed

  パーキンソン病;αシヌクレイン;リポソーム;脂質膜;カンチレバーセンサ;フィブリル;モノマー;糖脂質;オリゴマー;バイオセンサ;αーシヌクレイン;カンチレバー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22964/
• Pathogenesis and treatment of multiple system atrophy

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Hodaka Yamakado

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  多系統萎縮症;脳神経疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09672/
• Unveiling the Pathological Mechanisms and Developing New Treatment of Parkinsons Disease Caused by GBA1 Mutations

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Ryosuke Takahashi

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  パーキンソン病;αシヌクレイン;脂質;GBA1;メダカ;マウス;ゴーシェ病;脳神経疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02540/
• Investigating the pathomechanism underlying idiopathic Parkinson's disease using patient-derived iPS cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Hodaka Yamakado

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860666/
• Exploring the pathomechanism of Pakinson's disease by novel alpha-synuclein transgenic mice

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  HODAKA YAMAKADO

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790879/
• プルキンエ細胞およびバーグマングリア特異的Sept7欠損マウスの解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Nagoya University;Kyoto University

  木下 専

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  細胞骨格;ノックアウトマウス;微細形態;行動;神経変性疾患;膜骨格;拡散障壁;コンディショナルノックアウト;バーグマングリア;プルキンエ細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20022022/
• Elucidation of the pathogenesis and development of disease-modifying therapies targeting neurodegenerative disorders by proteolytic system

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  山門 穂高

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18575/
• Basic technology of lipid membrane immunosensor for detection of pathogenic protein in blood contributing to ultra-early diagnosis of dementia

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kansai University;Kyoto Institute of Technology

  野田 実

  From 30 Jun. 2023, To 31 Mar. 2026, Granted

  イムノセンサ;認知症超早期診断;血中病因タンパク質;抗体様分子;脂質膜;自己鋳型化効果;異常凝集タンパク質;物理センサ;原因タンパク質;抗体様低分子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K17476/
• プリオン様タンパク質の凝集を起点としたパーキンソン病の診断と治療薬の開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52020:Neurology-related

  Kyoto University

  山門 穂高

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02369/
• 多系統萎縮症のαシヌクレイン凝集体形成における神経細胞の役割の解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 51030:Pathophysiologic neuroscience-related

  Kyoto University

  大野 美樹

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  多系統萎縮症;αシヌクレイン;オリゴデンドロサイト

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K10645/

Administration

Faculty management (title, position)

• From 01 Apr. 2026, To 30 Sep. 2026

  医学研究科・医学部動物実験委員会_委員
• From 01 Apr. 2013, To 31 Mar. 2014

  動物実験施設運営委員会
• From 01 Apr. 2014

  外来医長・看護師長会議 委員