Basic Information

Affiliated programs (koza)

• Graduate School of Engineering, 分子工学専攻（細孔物理化学分野）分子材料科学講座, 講師

Academic Degree

• Ｍ．Ｓ．（生物工学）(マドラス大学)
• 博士（学術）(新潟大学)

Research History

• From Oct. 2018, To Present

  Rutgers University, USA, KiBum Lab, Visiting Faculty
• From Aug. 2018, To Present

  Kyoto University, iCeMS, Principal Investigator
• From Jul. 2018, To Present

  Kyoto University, iCeMS, Junior Associate Professor (Tenured)
• From Mar. 2018, To Present

  AO Research Institute, Switzerland, Department of Musculoskeletal Regeneration, Visiting Faculty
• From Mar. 2016, To Jun. 2018

  Kyoto University, iCeMS, Assistant Professor (Tenured)
• From Mar. 2014, To Feb. 2016

  Kyoto University, iCeMS, Program-Specific Research Center Assistant Professor
• From Jan. 2010, To Feb. 2014

  Kyoto University, iCeMS, Research Associate
• From Apr. 2009, To Jan. 2010

  Niigata University, Hori Lab, Division of Applied Biosciences, Research Assistant Professor
• From Oct. 2009, To Dec. 2009

  Ushiki and Associates Patent Office, Niigata Office, Visiting Scientific Advisor
• From Oct. 2003, To Jan. 2006

  Indian Institute of Technology-Madras (IIT‐M), Department of Biotechnology, Project Associate
• From Nov. 2004, To Oct. 2005

  Kelvin Chemicsls, Chennai Branch, Visiting Scientist
• From Jun. 2002, To Oct. 2003

  Indian Institute of Technology-Madras (IIT‐M), Department of Chemistry, Research Assistant

ID,URL

• ORCID ID

  0000-0002-5531-1995

• J-Global ID

  201401089727002803

• Researcher number

  20625446

• External link

  https://www.namasivayam.icems.kyoto-u.ac.jp/

researchmap URL

• https://researchmap.jp/7000008872

Research

Research Topics, Overview of the research

• Research Topics

  Small Molecules to control cell fate

• Overview of the research

  Natural epigenetic processes precisely orchestrate the intricate gene network by switching “ON” and “OFF” the genes at the right place and time to regulate cellular homeostasis and phenotype. Epigenetic enzymes like histone deacetylases (HDACs) and histone acetyltransferases (HATs) organize histone acetylation and chromatin architecture to govern endogenous gene expression. Pathological chromatin alterations are inherently flexible and can be reversed through pharmacological intervention. HDAC inhibiting small molecules like suberoylanilide hydroxamic acid (SAHA) have been harnessed to modulate gene expression. However, they operate in a sequence-independent manner (Biotechnol. J., 2012, 7, 798). Taking cues from natural transcription factors, we developed a novel class of compound termed, SAHA-PIP containing sequence-specific pyrrole-imidazole polyamides (PIPs) and SAHA. Screening studies in mouse embryonic fibroblasts (MEFs) showed that certain SAHA-PIPs triggered epigenetic marks associated with transcriptionally permissive chromatin and differentially activated the pluripotency genes like Oct-3/4, Sox2, Klf4 and c-Myc (ChemBioChem., 2011, 12, 2822). Genome-wide gene analysis revealed a SAHA-PIP termed `δ` could multiple pluripotency genes in MEF by more than ten-fold to initiate cellular reprogramming in just 24 h (Sci. Rep., 2012, 2, e544).
  
  Evaluation of the effect of SAHA-PIPs on genome-wide gene expression in human dermal fibroblasts (HDFs) divulged that each SAHA-PIP could differentially activate the therapeutically important genes like anti-HIV MX2 and anti-obesity KSR2 (Sci. Rep., 2014, 4, e3843). Among them, the notable `ON` switching SAHA-PIPs in HDFs include `K` for germ cell-associated PIWI pathway genes (Angew. Chem. Int. Ed. 2013, 124, 13652 [HOT PAPER]) and `I` for pluripotency-associated OCT4 pathway genes (ACS Chem. Biol. 2014, 9, 2729). Conjugation of DNA binding domain of `I` with HAT activating N- (4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide (CTB) remarkably activated identical cluster of genes as SAHA-PIP `I` to substantiate the role of PIP in sequence-specific gene regulation (Angew. Chem. Int. Ed. 2015, 54, 8700). Since PIP conjugates can be tailored to bind predetermined DNA sequences, strategies to expand DNA-based epigenetic switches could create an epoch-making approach in cellular reprogramming and therapeutic gene regulation.

Research Interests

• Nanotechnology
• Epigenetics
• Cellular reprogramming
• Bio-inspired therapeutics
• Artificial genetic switches

Research Areas

• Nanotechnology/Materials, Chemical biology
• Life sciences, Genomics, Therapeutic gene modulation
• Life sciences, Biomaterials, Nature-inspired Biomaterials
• Life sciences, Biomedical engineering, Nature-inspired Biomaterials

Papers

• Creation of Metal-Complex-Integrated Tensegrity Triangle DNA Crystals

  Katsuhiko Abe; Haruhiko Eki; Yuki Hirose; Soyoung Park; Shanmugavel Chinnathambi; Ganesh Pandian Namasivayam; Kazuki Takeda; Hiroshi Sugiyama; Masayuki Endo

  Molecules, 01 Oct. 2024

  
• Clock-Sleep Communication

  Seithikurippu R. Pandi-Perumal; Sayan Paul; Konda Mani Saravanan; Ganesh Pandian Namasivayam; Saravana Babu Chidambaram

  Current Molecular Medicine, Apr. 2025

  
• DNA Methylation Modification Patterns Identify Distinct Prognosis and Responses to Immunotherapy and Targeted Therapy in Renal Cell Carcinoma

  Dan Bai; Yan Cheng; Xiaolan Lu; Ganesh Pandian Namasivayam; Hiroshi Sugiyama

  Frontiers in Bioscience-Landmark, 26 Sep. 2023

  
• Surface charge-dependent cytokine production using near-infrared emitting silicon quantum dots

  Shanmugavel Chinnathambi; Naoto Shirahata; Pooria Lesani; Vaijayanthi Thangavel; Ganesh N. Pandian

  Scientific Reports, Dec. 2024

  
• Waking Up the Sleep Field: An Overview on the Implications of Genetics and Bioinformatics of Sleep

  Seithikurippu R. Pandi-Perumal; Konda Mani Saravanan; Sayan Paul; Ganesh Pandian Namasivayam; Saravana Babu Chidambaram

  Molecular Biotechnology, May 2024

  
• Subcutaneous adipose tissue: Implications in dermatological diseases and beyond

  Reihane Ziadlou; Ganesh N. Pandian; Jürg Hafner; Cezmi A. Akdis; Georg Stingl; Emanual Maverakis; Marie‐Charlotte Brüggen

  Allergy, Dec. 2024

  
• Bat-associated microbes: Opportunities and perils, an overview

  J. Dhivahar; Anutthaman Parthasarathy; Kathiravan Krishnan; Basavaraj S. Kovi; Ganesh N. Pandian

  Heliyon, Dec. 2023

  
• MOFs for next-generation cancer therapeutics through a biophysical approach—a review

  Leon Bernet Shano; Subramani Karthikeyan; Lourdusamy John Kennedy; Shanmugavel Chinnathambi; Ganesh N. Pandian

  Frontiers in Bioengineering and Biotechnology, 13 Jun. 2024

  
• Biomass-derived carbon dots as fluorescent quantum probes to visualize and modulate inflammation

  Mahima Kumar; Shanmugavel Chinnathambi; Noremylia Bakhori; Norhidayah Abu; Fatemeh Etezadi; Vaijayanthi Thangavel; Daniel Packwood; Easan Sivaniah; Ganesh N. Pandian

  Scientific Reports, 03 Jun. 2024

  
• Chalcone derivatives' interaction with human serum albumin and cyclooxygenase-2

  Subramani Karthikeyan; Ayyavu Thirunarayanan; Leon Bernet Shano; Arasappan Hemamalini; Anandh Sundaramoorthy; Rajendiran Mangaiyarkarasi; Norhidayah Abu; Singaravelu Ganesan; Shanmugavel Chinnathambi; Ganesh N. Pandian

  RSC Advances, 2024

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• Nano–bio interaction between human immunoglobulin G and nontoxic, near-infrared emitting water-borne silicon quantum dot micelles

  Shanmugavel Chinnathambi; Naoto Shirahata; Mahima Kumar; Subramani Karthikeyan; Katsuhiko Abe; Vaijayanthi Thangavel; Ganesh N. Pandian

  RSC Advances, 2023

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• Nucleic acid‐based small molecules as targeted transcription therapeutics for immunoregulation

  Dan Bai; Reihane Ziadlou; Thangavel Vaijayanthi; Subramani Karthikeyan; Shanmugavel Chinnathambi; Anutthaman Parthasarathy; Li Cai; Marie‐Charlotte Brüggen; Hiroshi Sugiyama; Ganesh N. Pandian

  Allergy, 06 Dec. 2023

  
• Pyrrole–Imidazole Polyamides – A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs

  Thangavel Vaijayanthi; Ganesh N. Pandian; Hiroshi Sugiyama

  Advanced Therapeutics, Jul. 2023

  
• A biophysical approach of cytarabine anticancer drug insights into human serum albumin and checkpoint kinase 1

  Rupavarshini, M.; Karthikeyan, S.; Anandh, S.; Ramamoorthi, A.; Ramakrishnamurthy, S.; Bharanidharan, G.; Aruna, P.; Mangaiyarkarasi, R.; Chinnathambi, S.; Pandian, G.N.; Ganesan, S.

  Results in Chemistry, 2023

  
• Scientists Against War: A Plea to World Leaders for Better Governance

  Seithikurippu R. Pandi-Perumal; Velayudhan Mohan Kumar; Namasivayam Ganesh Pandian; Joop T. de Jong; Sudalaikannu Andiappan; Alexandru Corlateanu; Arehally Marappa Mahalaksmi; Saravana Babu Chidambaram; Ramasamy Rajesh Kumar; Chellamuthu Ramasubramanian; Sudhakar Sivasubramaniam; Alvhild Alette Bjørkum; JosAnn Cutajar; Michael Berk; Ilya Trakht; Anton Vrdoljak; Miguel Meira e Cruz; Harris A. Eyre; Janne Grønli; Dainiel P. Cardinali; Andreas Maercker; Willem A. C. M. van de Put; Jaswant Guzder; Bjørn Bjorvatn; Wietse A. Tol; Darío Acuña-Castroviejo; Marie Meudec; Charles M. Morin; Markku Partinen; Corrado Barbui; Mark J. D. Jordans; Mario H. Braakman; Christine Knaevelsrud; Ståle Pallesen; Marit Sijbrandij; Diego Andrés Golombek; Colin A. Espie; Pim Cuijpers; Hernán Andrés Marín Agudelo; Koos van der Velden; Bessel A. van der Kolk; Stevan E. Hobfoll; Walter L. J. M. Devillé; Michael Gradisar; Dieter Riemann; John Axelsson; Gloria Benítez-King; Robert D. Macy; Vitalii Poberezhets; Samuel Ratnajeevan Herbert Hoole; Rangaswamy Srinivasa Murthy; Thomas Hegemann; Andreas Heinz; Jane Salvage; Alexander C. McFarlane; Rob Keukens; Harendra de Silva; Cornelia Oestereich; Jochen Wilhelm; Michael von Cranach; Klaus Hoffmann; Matthias Klosinski; Dinesh Bhugra; Mary V. Seeman

  Sleep and Vigilance, Jun. 2022

  
• Facile Synthesis of Hafnium Oxide Nanoparticle Decorated on Graphene Nanosheet and Its Photocatalytic Degradation of Organic Pollutants under UV-Light Irradiation

  Jayaraman, V.; Mahalingam, S.; Chinnathambi, S.; Pandian, G.N.; Prakasarao, A.; Ganesan, S.; Ramasamy, J.; Ayyaru, S.; Ahn, Y.-H.

  Applied Sciences (Switzerland), 2022

  
• Nanoparticle-Based Artificial Mitochondrial DNA Transcription Regulator: MitoScript

  Yang, L.; Rathnam, C.; Hidaka, T.; Hou, Y.; Conklin, B.; Pandian, G.N.; Sugiyama, H.; Lee, K.-B.

  Nano Letters, 2022

  
• Artificial intelligence in microbial natural product drug discovery: current and emerging role

  Vinodh J. Sahayasheela; Manendra B. Lankadasari; Vipin Mohan Dan; Syed G. Dastager; Ganesh N. Pandian; Hiroshi Sugiyama

  Natural Product Reports, 2022

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• Mitochondria and G-quadruplex evolution: an intertwined relationship

  Vinodh J. Sahayasheela; Zutao Yu; Takuya Hidaka; Ganesh N. Pandian; Hiroshi Sugiyama

  Trends in Genetics, Jan. 2023

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• Structural colour enhanced microfluidics.

  Detao Qin; Andrew H Gibbons; Masateru M Ito; Sangamithirai Subramanian Parimalam; Handong Jiang; H Enis Karahan; Behnam Ghalei; Daisuke Yamaguchi; Ganesh N Pandian; Easan Sivaniah

  Nature communications, 19 May 2022

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• An informatics approach to distinguish RNA modifications in nanopore direct RNA sequencing.

  Soundhar Ramasamy; Shubham Mishra; Surbhi Sharma; Sangamithirai Subramanian Parimalam; Thangavel Vaijayanthi; Yoto Fujita; Basavaraj Kovi; Hiroshi Sugiyama; Ganesh N Pandian

  Genomics, 20 Apr. 2022, Peer-reviewed, Last author, Corresponding author

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• Classification of COVID-19 from chest x-ray images using deep features and correlation coefficient.

  Rahul Kumar; Ridhi Arora; Vipul Bansal; Vinodh J Sahayasheela; Himanshu Buckchash; Javed Imran; Narayanan Narayanan; Ganesh N Pandian; Balasubramanian Raman

  Multimedia tools and applications, 28 Mar. 2022

  
• Comparative analysis of mitochondrial genomes in different species reveals the evolution of G-quadruplexes

  Hiroshi Sugiyama; Vinodh Sahayasheela; Zutao Yu; Ganesh Pandian

  01 Dec. 2021, Corresponding author

  
• AI-based diagnosis of COVID-19 patients using X-ray scans with stochastic ensemble of CNNs

  Ridhi Arora; Vipul Bansal; Himanshu Buckchash; Rahul Kumar; Vinodh J. Sahayasheela; Narayanan Narayanan; Ganesh N. Pandian; Balasubramanian Raman

  Physical and Engineering Sciences in Medicine, Dec. 2021, Peer-reviewed

  
• Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model

  Malinee, M.; Pandian, G.N.; Sugiyama, H.

  Cell Chemical Biology, 2022, Peer-reviewed, Corresponding author

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• Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation.

  Takuya Hidaka; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Hiroshi Sugiyama

  Cell chemical biology, 24 Aug. 2021, Peer-reviewed, Corresponding author

  
• Designing Biomimicking Synthetic Transcription Factors for Therapeutic Gene Modulation

  Ganesh N. Pandian; Hiroshi Sugiyama

  Cell-Inspired Materials and Engineering, 2021, Peer-reviewed, Corresponding author

  
• Sequence-Specific Control of Using Programmable Synthetic Gene Switches Called MITO-PIPs

  Takuya Hidaka; Hiroshi Sugiyama; Ganesh N. Pandian

  Methods in Molecular Biology, 2021, Peer-reviewed, Last author, Corresponding author

  
• Chemical probe-based Nanopore Sequencing to Selectively Assess the RNA modifications

  Soundhar Ramasamy; Vinodh J Sahayasheela; Zutao Yu; Takuya Hidaka; Li Cai; Hiroshi Sugiyama; Ganesh N. Pandian

  ACS Chemical Biology, 20 May 2020, Last author, Corresponding author

  
• Targeted epigenetic modulation using a DNA‐based histone deacetylase inhibitor enhances cardiomyogenesis in mouse embryonic stem cells

  Jin‐A Lee; Jieun An; Junichi Taniguchi; Gengo Kashiwazaki; Ganesh N. Pandian; Nazia Parveen; Tong Mook Kang; Hiroshi Sugiyama; Debojyoti De; Kyeong Kyu Kim

  Journal of Cellular Physiology, 08 Nov. 2020

  
• A Near-Infrared Fluorogenic Pyrrole–Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres

  Yutaro Tsubono; Yusuke Kawamoto; Takuya Hidaka; Ganesh N Pandian; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Journal of the American Chemical Society, 21 Sep. 2020, Peer-reviewed, Corresponding author

  
• Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract

  Nor Amira Khurshid Ahmed; Shern Kwok Lim; Ganesh Pandian; Hiroshi Sugiyama; Chong Yew Lee; Boon Yin Khoo; Kit Lam Chan

  Molecular Medicine Reports, 02 Sep. 2020, Peer-reviewed

  
• Enhanced nuclear accumulation of pyrrole–imidazole polyamides by incorporation of the tri-arginine vector

  Takuya Hidaka; Yutaro Tsubono; Kaori Hashiya; Toshikazu Bando; Ganesh N. Pandian; Hiroshi Sugiyama

  Chemical Communications, Sep. 2020, Peer-reviewed

  
• Discovery of 3-(benzofuran-2-ylmethyl)-1H-indole derivatives as potential autophagy inducers in cervical cancer cells.

  Shaziyaparveen K Siddiqui; Vinodh J SahayaSheela; Srinivas Kolluru; Ganesh N Pandian; Thankayyan R Santhoshkumar; Vipin M Dan; Chepuri V Ramana

  Bioorganic & medicinal chemistry letters, 23 Jul. 2020, Peer-reviewed

  
• Accurate Prediction of COVID-19 using Chest X-Ray Images through Deep Feature Learning model with SMOTE and Machine Learning Classifiers

  Rahul Kumar; Ridhi Arora; Vipul Bansal; Vinodh J Sahayasheela; Himanshu Buckchash; Javed Imran; Narayanan Narayanan; Ganesh N Pandian; Balasubramanian Raman

  17 Apr. 2020, Peer-reviewed, Corresponding author

  
• A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus.

  Zutao Yu; Mengting Ai; Soumen K Samanta; Fumitaka Hashiya; Junichi Taniguchi; Sefan Asamitsu; Shuji Ikeda; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Lyle Isaacs; Hiroshi Sugiyama

  Chemical communications (Cambridge, England), 20 Feb. 2020, Peer-reviewed

  
• CGHF: A Computational Decision Support System for Glioma Classification Using Hybrid Radiomics- and Stationary Wavelet-Based Features.

  Rahul Kumar 0003; Ankur Gupta 0002; Harkirat Singh Arora; Ganesh Namasivayam Pandian; Balasubramanian Raman

  IEEE Access, 2020, Peer-reviewed

  
• Targeted suppression of metastasis regulatory transcription factor SOX2 in various cancer cell lines using a sequence-specific designer pyrrole-imidazole polyamide.

  Madhu Malinee; Alok Kumar; Takuya Hidaka; Masanobu Horie; Kouichi Hasegawa; Ganesh N Pandian; Hiroshi Sugiyama

  Bioorganic & medicinal chemistry, Dec. 2019, Peer-reviewed

  
• Therapeutic gene regulation using pyrrole–imidazole polyamides

  Zutao Yu; Ganesh N. Pandian; Takuya Hidaka; Hiroshi Sugiyama

  Advanced Drug Delivery Reviews, Jul. 2019, Peer-reviewed

  
• Chemical control system of epigenetics

  T. Vaijayanthi; Ganesh N. Pandian; H. Sugiyama

  The Chemical Record - Wiley Online Library, Oct. 2018, Peer-reviewed

  
• Direct observation of H3‐H4 octasome by high‐speed AFM

  Ganesh Pandian

  Chemistry-A European Journal, 08 Aug. 2018, Peer-reviewed

  
• Colloidal stability of lipid/protein-coated nanomaterials in salt and sucrose solutions.

  T. Nobeyama; M. Mori; K. Shiyou; Ganesh N. Pandian; H. Sugiyama; T. Murakami

  ChemistrySelect, Jul. 2018, Peer-reviewed

  
• Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones

  Junichi Taniguchi; Yihong Feng; Ganesh N. Pandian; Fumitaka Hashiya; Takuya Hidaka; Kaori Hashiya; Soyoung Park; Toshikazu Bando; Shinji Ito; Hiroshi Sugiyama

  Journal of the American Chemical Society, 13 Jun. 2018, Peer-reviewed

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• Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation

  Yulei Wei; Ganesh N. Pandian; Zutao Yu; Tingting Zou; Yue Li; Jayant Darokar; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  ACS Omega, 2018, Peer-reviewed

  
• Low temperature carbonization of chicken manure to char and its effect on growth of Oryza sativa L. Koshihikari and Brassica rapa komatsuna

  Ishimori, T.; Takahashi, Y.; Sato, H.; Hassan, A.; Iwamoto, Y.; Pandian, G.N.; Hori, H.

  Euro-Mediterranean Journal for Environmental Integration, May 2017, Peer-reviewed

  
• Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression

  Hidaka, Takuya; Pandian, Ganesh N.; Taniguchi, Junichi; Nobeyama, Tomohiro; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  Journal of the American Chemical Society, 2017, Peer-reviewed

  
• Antiproliferative and apoptotic activities of sequence-specific histone acetyltransferase inhibitors

  Yu, Zutao; Taniguchi, Junichi; Wei, Yulei; Pandian, Ganesh N.; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  European Journal of Medicinal Chemistry, 2017, Peer-reviewed

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• A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm

  Taniguchi, Junichi; Pandian, Ganesh N.; Hidaka, Takuya; Hashiya, Kaori; Bando, Toshikazu; Kim, Kyeong Kyu; Sugiyama, Hiroshi

  Nucleic Acids Research, 2017, Peer-reviewed

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• Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B-2 to Duplex DNA

  Zou, Tingting; Kizaki, Seiichiro; Pandian, Ganesh N.; Sugiyama, Hiroshi

  Chemistry-a European Journal, 2016, Peer-reviewed

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• Nature-Inspired Design of Smart Biomaterials Using the Chemical Biology of Nucleic Acids

  Pandian, Ganesh N.; Sugiyama, Hiroshi

  Bulletin of the Chemical Society of Japan, 2016, Peer-reviewed

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• A Multi-target Small Molecule for Targeted Transcriptional Activation of Therapeutically Significant Nervous System Genes

  Wei, Yulei; Pandian, Ganesh N.; Zou, Tingting; Taniguchi, Junichi; Sato, Shinsuke; Kashiwazaki, Gengo; Vaijayanthi, Thangavel; Hidaka, Takuya; Bando, Toshikazu; Sugiyama, Hiroshi

  Chemistryopen, 2016, Peer-reviewed

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• Red fluorescent gut proteins in the mulberry silkworm with immunomodulatory properties

  Ganesh-pandian Namasivayam

  Trends in Entomology, 2016, Peer-reviewed

  
• Synthetic strategies to identify and regulate noncoding RNAs

  Ganesh N. Pandian; Junetha Syed; Hiroshi Sugiyama

  Long Noncoding RNAs Structures and Functions, 01 Jan. 2015, Peer-reviewed

  
• Advancing Small-Molecule-Based Chemical Biology with Next-Generation Sequencing Technologies

  Anandhakumar, Chandran; Kizaki, Seiichiro; Bando, Toshikazu; Pandian, Ganesh N.; Sugiyama, Hiroshi

  Chembiochem, 2015, Peer-reviewed

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• Integrating Epigenetic Modulators into NanoScript for Enhanced Chondrogenesis of Stem Cells

  Patel, Sahishnu; Pongkulapa, Thanapat; Yin, Perry T.; Pandian, Ganesh N.; Rathnam, Christopher; Bando, Toshikazu; Vaijayanthi, Thangavel; Sugiyama, Hiroshi; Lee, Ki-Bum

  Journal of the American Chemical Society, 2015, Peer-reviewed

  
• A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts

  Syed, Junetha; Chandran, Anandhakumar; Pandian, Ganesh N.; Taniguchi, Junichi; Sato, Shinsuke; Hashiya, Kaori; Kashiwazaki, Gengo; Bando, Toshikazu; Sugiyama, Hiroshi

  Chembiochem, 2015, Peer-reviewed

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• A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network

  Han, Le; Pandian, Ganesh N.; Chandran, Anandhakumar; Sato, Shinsuke; Taniguchi, Junichi; Kashiwazaki, Gengo; Sawatani, Yoshito; Hashiya, Kaori; Bando, Toshikazu; Xu, Yufang; Qian, Xuhong; Sugiyama, Hiroshi

  Angewandte Chemie-International Edition, 2015, Peer-reviewed

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• Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy against Pluripotency Genes in Mouse Fibroblasts

  Abhijit Saha; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Yusuke Kawamoto; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  CHEMMEDCHEM, Oct. 2014, Peer-reviewed

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• Alteration of epigenetic program to recover memory and alleviate neurodegeneration: Prospects of multi-target molecules

  Ganesh N. Pandian; Rhys D. Taylor; Syed Junetha; Abhijit Saha; Chandran Anandhakumar; Thangavel Vaijayanthi; Hiroshi Sugiyama

  Biomaterials Science, Aug. 2014, Peer-reviewed

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• Targeted editing of therapeutic genes using DNA-based transcriptional activators: Scope and challenges

  Ganesh N. Pandian; Hiroshi Sugiyama

  Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications, 01 Jan. 2014, Peer-reviewed

  
• Cellular reprogramming for pancreatic beta-cell regeneration: clinical potential of small molecule control.

  Pandian; Ganesh N.; Taniguchi, Junichi; Sugiyama, Hiroshi

  Clinical and translational medicine, 2014, Peer-reviewed

  
• Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy against Pluripotency Genes in Mouse Fibroblasts

  Saha, Abhiji; Pandian; Ganesh N.; Sato, Shinsuke; Taniguchi, Junichi; Kawamoto, Yusuke; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  Chemmedchem, 2014, Peer-reviewed

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• Targeted Suppression of EVI1 Oncogene Expression by Sequence-Specific Pyrrole-Imidazole Polyamide

  Syed, Junetha; Pandian, Ganesh N.; Sato, Shinsuke; Taniguchi, Junichi; Chandran, Anandhakumar; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  Chemistry & Biology, 2014, Peer-reviewed

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• Identification of a Small Molecule That Turns ON the Pluripotency Gene Circuitry in Human Fibroblasts

  Pandian, Ganesh N.; Sato, Shinsuke; Anandhakumar, Chandran; Taniguchi, Junichi; Takashima, Kazuhiro; Syed, Junetha; Han, Le; Saha, Abhijit; Bando, Toshikazu; Nagase, Hiroki; Sugiyama, Hiroshi

  Acs Chemical Biology, 2014, Peer-reviewed

  
• Next-Generation Sequencing Studies Guide the Design of Pyrrole-Imidazole Polyamides with Improved Binding Specificity by the Addition of beta-Alanine

  Anandhakumar, Chandran; Li, Yue; Kizaki, Seiichiro; Pandian, Ganesh N.; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  Chembiochem, 2014, Peer-reviewed

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• Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts

  Pandian, Ganesh N.; Taniguchi, Junichi; Junetha, Syed; Sato, Shinsuke; Han, Le; Saha, Abhijit; AnandhaKumar, Chandran; Bando, Toshikazu; Nagase, Hiroki; Vaijayanthi, Thangavel; Taylor, Rhys D.; Sugiyama, Hiroshi

  Scientific Reports, 2014, Peer-reviewed

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• A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell

  Le Han; Ganesh N. Pandian; Syed Junetha; Shinsuke Sato; Chandran Anandhakumar; Junichi Taniguchi; Abhijit Saha; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Dec. 2013, Peer-reviewed

  
• Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources

  Yan-Ling Wu; Ganesh N. Pandian; Yan-Ping Ding; Wen Zhang; Yoshimasa Tanaka; Hiroshi Sugiyama

  CHEMISTRY & BIOLOGY, Nov. 2013, Peer-reviewed

  
• Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach

  Shigeo Masuda; Jun Wu; Tomoaki Hishida; Ganesh N. Pandian; Hiroshi Sugiyama; Juan Carlos Izpisua Belmonte

  JOURNAL OF MOLECULAR CELL BIOLOGY, Oct. 2013, Peer-reviewed

  
• Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity

  Abhijit Saha; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2013, Peer-reviewed

  
• Design of a new fluorescent probe: Pyrrole/imidazole hairpin polyamides with pyrene conjugation at their gamma-turn

  Thangavel Vaijayanthi; Toshikazu Bando; Kaori Hashiya; Ganesh N. Pandian; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2013, Peer-reviewed

  Access this paper :

  
• GSM1289295: HDF_SAHA-PIP2_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013, Peer-reviewed

  
• GSM1289294: HDF_SAHA-PIP1_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013, Peer-reviewed

  
• GSM1289293: HDF_DMSO_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013, Peer-reviewed

  
• GSM1289292: HDF_SAHA_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013, Peer-reviewed

  
• GSM1289291: HDF_SAHA-PIP9_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013, Peer-reviewed

  
• E-GEOD-53318.sdrf.txt

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53318.raw.1.zip

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53318.processed.1.zip

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53318.idf.txt

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53317.sdrf.txt

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53317.raw.2.zip

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53317.raw.1.zip

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53317.processed.1.zip

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53317.idf.txt

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53316.sdrf.txt

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53316.raw.1.zip

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53316.processed.1.zip

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013, Peer-reviewed

  
• E-GEOD-53316.idf.txt

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013, Peer-reviewed

  
• A-GEOD-17692.adf.txt

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013, Peer-reviewed

  
• A-GEOD-17077.adf.txt

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• A-GEOD-13497.adf.txt

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013, Peer-reviewed

  
• Strategies to modulate heritable epigenetic defects in cellular machinery: Lessons from nature

  Ganesh N. Pandian; Hiroshi Sugiyama

  Pharmaceuticals, 27 Dec. 2012, Peer-reviewed

  
• Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes

  Thangavel Vaijayanthi; Toshikazu Bando; Ganesh N. Pandian; Hiroshi Sugiyama

  CHEMBIOCHEM, Oct. 2012, Peer-reviewed

  
• A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts

  Ganesh N. Pandian; Yusuke Nakano; Shinsuke Sato; Hironobu Morinaga; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama

  SCIENTIFIC REPORTS, Jul. 2012, Peer-reviewed

  Access this paper :

  
• Programmable genetic switches to control transcriptional machinery of pluripotency

  Ganesh N. Pandian; Hiroshi Sugiyama

  BIOTECHNOLOGY JOURNAL, Jun. 2012, Peer-reviewed

  
• Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes

  Ganesh N. Pandian; Akimichi Ohtsuki; Toshikazu Bando; Shinsuke Sato; Kaori Hashiya; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2012, Peer-reviewed

  Access this paper :

  
• Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N-Methylpyrrole-N-Methylimidazole Polyamide Conjugates

  Gengo Kashiwazaki; Toshikazu Bando; Tomofumi Yoshidome; Seiji Masui; Toshiki Takagaki; Kaori Hashiya; Ganesh N. Pandian; Junichi Yasuoka; Kazunari Akiyoshi; Hiroshi Sugiyama

  JOURNAL OF MEDICINAL CHEMISTRY, Mar. 2012, Peer-reviewed

  
• Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes in Mouse Embryonic Fibroblasts

  Ganesh N. Pandian; Ken-ichi Shinohara; Akimichi Ohtsuki; Yusuke Nakano; Minoshima Masafumi; Toshikazu Bando; Hiroki Nagase; Yasuhiro Yamada; Akira Watanabe; Naohiro Terada; Shinsuke Sato; Hironobu Morinaga; Hiroshi Sugiyama

  CHEMBIOCHEM, Dec. 2011, Peer-reviewed

  
• Midgut juice of Plutella xylostella highly resistant to Bacillus thuringiensis Cry1Ac contains a three times larger amount of glucosinolate sulfatase which binds to Cry1Ac compared to that of susceptible strain

  Takanori Yamazaki; Toshiki Ishikawa; Ganesh N. Pandian; Keiichi Okazaki; Kohsuke Haginoya; Yuka Tachikawa; Toshiaki Mitsui; Kazuhisa Miyamoto; Chanan Angusthanasombat; Hidetaka Hori

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, Oct. 2011, Peer-reviewed

  
• Depletion of 14-3-3 Protein Exacerbates Cardiac Oxidative Stress, Inflammation and Remodeling Process via Modulation of MAPK/NF-kappa B Signaling Pathways after Streptozotocin-induced Diabetes Mellitus

  Rajarajan A. Thandavarayan; Vijayasree V. Giridharan; Flori R. Sari; Somasundaram Arumugam; Punniyakoti T. Veeraveedu; Ganesh N. Pandian; Suresh S. Palaniyandi; Meilei Ma; Kenji Suzuki; Narasimman Gurusamy; Kenichi Watanabe

  CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2011, Peer-reviewed

  
• Formation of Macromolecule Complex with Bacillus thuringiensis Cry1A Toxins and Chlorophyllide Binding 252-kDa Lipocalin-Like Protein Locating on Bombyx mori Midgut Membrane

  Ganesh N. Pandian; Toshiki Ishikawa; Thangavel Vaijayanthi; Delwar M. Hossain; Shuhei Yamamoto; Tadayuki Nishiumi; Chanan Angsuthanasombat; Kohsuke Haginoya; Toshiaki Mitsui; Hidetaka Hori

  JOURNAL OF MEMBRANE BIOLOGY, Oct. 2010, Peer-reviewed

  
• Investigation of physicochemical condition to stabilize phosphatidylcholine-liposome enclosing fluorescent calcein and its exploitation for analysis of pore formation with Cry1A toxins of Bacillus thuringiensis

  Kohsuke Haginoya; Vaijayanthi Thangavel; Ganesh N. Pandian; Kazuya Tomimoto; Yasuyuki Shitomi; Masaaki Azuma; Chanan Angsuthanasombat; Hidetaka Hori

  APPLIED ENTOMOLOGY AND ZOOLOGY, Aug. 2010, Peer-reviewed

  
• Novel applications of silicon and porous silicon based EISCAP biosensors

  Arun Mathew; Ganesh Pandian; Enakshi Bhattacharya; Anju Chadha

  PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, Jun. 2009, Peer-reviewed

  
• Bombyx mori midgut membrane protein P252, which binds to Bacillus thuringiensis Cry1A, is a chlorophyllide-binding protein, and the resulting complex has antimicrobial activity

  Ganesh N. Pandian; Toshiki Ishikawa; Makoto Togashi; Yasuyuki Shitomi; Kohsuke Haginoya; Shuhei Yamamoto; Tadayuki Nishiumi; Hidetaka Hori

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Mar. 2008, Peer-reviewed

  
• Characterization of a Cry1A and chlorophyllide-binding 252-kDa protein and its antimicrobial and physiological applications

  Ganesh-pandian Namasivayam

  Proc. of International conference on Bacillus thuringiensis, 2007, Peer-reviewed

  
• Deracemisation of beta-hydroxy esters using immobilised whole cells of Candida parapsilosis ATCC 7330: substrate specificity and mechanistic investigation

  Santosh Kumar Padhi; D. Titu; N. Ganesh Pandian; Anju Chadha

  TETRAHEDRON, May 2006, Peer-reviewed

  
• Deracemisation of aryl substituted alpha-hydroxy esters using Candida parapsilosis ATCC 7330: effect of substrate structure and mechanism

  B Baskar; NG Pandian; K Priya; A Chadha

  TETRAHEDRON, Dec. 2005, Peer-reviewed

  
• Sensitive Silicon and Porous Silicon Triglyceride Biosensors.

  Ganesh-pandian Namasivayam

  Proc. of Intl. Workshop on Physics of Semiconductor Devices, 2005, Peer-reviewed

  
• Screening, characterization and application of an indigenous lipase.

  Ganesh-pandian Namasivayam

  Advanced Biotechnology, 2005

  
• Synthesis of optically pure α-hydroxy esters: A biocatalytic approach.

  Ganesh-pandian Namasivayam

  Advanced Biotechnology, 2005

  
• Preparation of chiral synthons: Biocatalytic deracemisation of aryl α-hydroxy esters.

  Ganesh-pandian Namasivayam

  Advanced Biotechnology, 2005

  
• Biocatalytic deracemization: An efficient and simple strategy for preparation of chiral α- and β-hydroxy esters.

  Ganesh-pandian Namasivayam

  Chemical Research in Chinese Universities, 2005

  
• Asymmetric reduction of alkyl 2-oxo-4-arylbutanoates and -but-3-enoates by Candida parapsilosis ATCC 7330: assignment of the absolute configuration of ethyl 2-hydroxy-4-(p-methylphenyl)but-3-enoate by H-1 NMR

  B Baskar; NG Pandian; K Priya; A Chadha

  TETRAHEDRON-ASYMMETRY, Dec. 2004, Peer-reviewed

  
• Microbial deracemisation of aromatic beta-hydroxy acid esters

  SK Padhi; NG Pandian; A Chadha

  JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, Jun. 2004, Peer-reviewed

  

Presentations

• Programming synthetic molecular codes for bioengineering

  Ganesh-pandian Namasivayam

  The Korean Society of Biotechnology and Bioengineering, 10 Oct. 2018, Invited

  
• Designer molecule to target and silence mitochondrial gene transcription

  Ganesh-pandian Namasivayam

  8th World congress on Targeting Mitochondria, Berlin, 23 Oct. 2017, Invited

  
• Nature-inspired smart genetic switches,

  Ganesh-pandian Namasivayam

  7th Indian JSPS Alumni Association (IJAA) International Conference on Science and Technology: Future Challenges and Solutions (STFCS-2016), 08 Aug. 2016, Invited

  
• Therapeutic gene modulation using DNA-based transcriptional activators

  Ganesh-pandian Namasivayam

  Asian International Symposium -Medicinal Chemistry in The 95th Annual Meeting of The Chemical Society of Japan, 27 Mar. 2015, Invited

  
• Therapeutic gene modulation using DNA-based transcriptional activators,

  Ganesh-pandian Namasivayam

  Asian International Symposium -Medicinal Chemistry in The 95th Annual Meeting of The Chemical Society of Japan, 26 Mar. 2015, Invited

  
• Alteration of global gene expression in human somatic cells using DNA-based epigenetic switches

  Ganesh-pandian Namasivayam

  ISSCR Regional Forum - Global control of stem cells, 05 Nov. 2014

  
• Bio-inspired genetic switches for therapeutic gene regulation

  Ganesh-pandian Namasivayam

  Ki-Bum lee Lab, Rutgers University, 21 Jul. 2014, Invited

  
• rtificial genetic `ON` switch

  Ganesh-pandian Namasivayam

  Rossi Lab, Harvard Medical School, 18 Jul. 2014, Invited

  
• Transcriptional regulation of silent developmental genes in somatic cells using DNA-based epigenetic switches

  Ganesh-pandian Namasivayam

  Cell Symposia - Transcriptional regulation in development, 13 Jul. 2014

  
• Synthetic small molecules to distinctively trigger transcriptional activation of pluripotency and germ-cell genes in a somatic cell

  Ganesh-pandian Namasivayam

  CiRA international symposium, 16 Jan. 2014

  
• DNA-based Epigenetic Switches to Control Cell Fate

  Ganesh-pandian Namasivayam

  0th International Symposium on Nucleic Acid Chemistry, 13 Nov. 2013

  
• Induced pluripotent stem cells and Genetic switches

  Ganesh-pandian Namasivayam

  Stem Cell Research Laboratory, 21 Sep. 2013, Invited

  
• Cellular reprogramming – A chemical approach

  Ganesh-pandian Namasivayam

  Madurai Kamraj University, 18 Sep. 2013, Invited

  
• Cellular time machine: Back to the future

  Ganesh-pandian Namasivayam

  Kalasalingam University, 17 Sep. 2013, Invited

  
• Genetic switches to control cellular time machine

  Ganesh-pandian Namasivayam

  Lady Doak College, 13 Sep. 2013, Invited

  
• Novel chemical approach for cellular reprograming

  Ganesh-pandian Namasivayam

  8th Annual Meeting of the Japanese Society for Chemical Biology, 19 Jun. 2013

  
• Targeting small molecules as transcriptional activators for selective induction of pluripotency genes in somatic fibroblasts

  Ganesh-pandian Namasivayam

  RSC-iCeMS Joint International Symposium: Cell-Material Integration and Biomaterials Science, 18 Mar. 2013

  
• Artificial epigenetic switches to selectively reprogram the transcriptional machinery conferring to cell fate

  Ganesh-pandian Namasivayam

  World Stem Cell Summit-2012, 01 Sep. 2012

  
• Synthetic genetic switches for selective induction of pluripotency in mouse and human fibroblasts

  Ganesh-pandian Namasivayam

  4th annual symposium of Institute for integrated cell-material sciences, 31 Aug. 2012

  
• Artificial genetic switches to induce pluripotency in somatic cells through directed chromatin remodeling

  Ganesh-pandian Namasivayam

  AAAS Science-Days of Molecular Medicine-2011, 10 Nov. 2011

  
• Synthetic transcription factors for stem cell control

  Ganesh-pandian Namasivayam

  Heidelberg-Kyoto Joint Symposium "Crossing Boundaries: Stem Cells, Materials, and Mesoscopic Sciences”, 21 Jul. 2011

  

Books and Other Publications

• Sequence-specific control of mitochondrial gene transcription using programmable synthetic gene switches called MITO-PIPs

  T. Hidaka; H. Sugiyama; Ganesh N. Pandian, Joint work

  Methods in Molecular Biology, Springer Protocols. Mitochondrial Medicine, 2nd edition, V. Weissig, M. Edeas, Editors. Humana Press, Springer New York Heidelberg Dordrecht London, 2020

  
• Synthetic strategies to identify and regulate noncoding RNAs in LONG NONCODING RNAs: Structures and Functions

  Ganesh-pandian Namasivayam, Joint work

  Springer Japan, Jun. 2015, Not refereed

  
• Targeted editing of therapeutic genes using DNA-based transcriptional activators: Scope and Challenges in Chemical Biology of Nucleic Acids

  Ganesh-pandian Namasivayam, Joint work

  Springer Berlin Heidelberg, Jan. 2014, Not refereed

  
• Designing biomimicking synthetic transcription factors for therapeutic gene modulation

  Ganesh-pandian Namasivayam, Joint work, Cell-inspired Materials and Engineering

  Springer, Not refereed

  

Awards

• 01 Oct. 2010

  2nd iCeMS retreat, Best Poster and Excellence Award
• 23 Jul. 2011

  Heidelberg-Kyoto Joint Symposium-2011, Best Poster Award
• 23 Jul. 2011

  Biotechnology Journal, Heidelberg-Kyoto Joint Symposium-2011, Biotechnology Journal Special Prize
• 12 Nov. 2011

  AAAS "Science" Days of Molecular Medicine -2011 , Young Investigator Award and Best Abstract
• 01 Sep. 2012

  4th annual iCeMS retreat, Spotlight Talk and Cross-Disciplinary Research Prize
• 19 Mar. 2013

  RSC-iCeMS Joint International Symposium-2013, Biomaterials Science Poster Award (First Prize)

Media Coverage

• がん免疫治療、効果高める手法。

  日経産業新聞, 14ページ, 19 Sep. 2021, Paper

  
• 「ミトコンドリア活性化」京大が中分子化合物を開発 マウス生存率向上

  科学新聞 1ページ, 17 Sep. 2021, Paper

  
• ＜めざまし8＞京大発表 ミトコンドリアでがん免疫治療薬の効果UP

  関西テレビ, 14 Sep. 2021, Media report

  
• がん免疫治療薬、有効性が向上、京都大教授ら、ミトコンドリア活性化で。

  日本経済新聞 9ページ, 14 Sep. 2021, Paper

  
• がん免疫療法効果増に期待 京大グループ 化合物開発

  京都新聞 29ページ, 14 Sep. 2021, Paper

  
• 京大、Ｔ細胞ミトコンドリア活性化 「オプジーボ」の効果向上

  日刊工業新聞 23ページ, 14 Sep. 2021, Paper

  
• オプジーボの効果高める化合物開発 ミトコンドリア活性化、京都大グループ

  京都新聞速報版, 14 Sep. 2021, Paper

  
• 京大、化合物で変異ミトコンドリアＤＮＡ減少 遺伝子治療に応用

  日刊工業新聞 33ページ, 31 Aug. 2021, Paper

  
• ＜やさしいニュース＞京都大学 難病のミトコンドリア病治療に可能性

  テレビ大阪, 27 Aug. 2021, Media report

  

External funds: Kakenhi

• 遺伝子ネットワークを制御する分子の開発と細胞への応用

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  杉山 弘

  From 05 Apr. 2021, To 31 Mar. 2024, Granted

  遺伝子発現制御;ミトコンドリア;AFM解析;ヌクレオソーム;DNAナノ構造体;遺伝子発現

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04705/
• Development of Artificial Transcription Factors for Cooperative Regulation of Cardiomyopathy-Related Mitochondrial and Nuclear Genes

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  Ganesh Pandian NAMASIVAYAM

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  Transcription therapy;Epigenetic codes;Mitochondria;Reactive Oxygen Species;Energy metabolism;Nanoparticle;Immunotherapy;Heteroplasmy;ピロールイミダゾールポリアミド;エピジェネティクス;人工転写因子;ナノテクノロジー;心筋症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03349/
• Induction of cardiomyocyte differenciation using a nano-particle based artificial transcription factor

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Pandian Namasivayam

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  ピロールイミダゾールポリアミド;人工転写因子;金ナノ粒子;分化誘導;遺伝子・核酸工学材料;遺伝子制御分子;細胞リプログラミング;心筋細胞;ミトコンドリア;人工ヒストンコード;ナノテクノロジー;リプログラミング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K12896/
• Nature-inspired small molecules for regulation of therapeutically important genes

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Ganesh Pandian NAMASIVAYAM

  From 01 Apr. 2014, To 31 Mar. 2015, Project Closed

  天然分子を模倣した化合物;DNAベースの治療;遺伝子発現制御;マルチターゲットな小分子化合物;エピゲノム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670055/
• Development of programmable small molecules capable of switching ON the transcriptional machinery of pluripotency genes.

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Ganesh Pandian NAMASIVAYAM

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  人工遺伝子スイッチ;細胞リプログラミング;小分子;合成生物学;iPS細胞;人口遺伝子スイッチ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24710261/
• Control and elucidation of gene expression at a molecular level

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Hiroshi SUGIYAMA

  From 31 May 2012, To 31 Mar. 2017, Project Closed

  遺伝子発現制御;エピジェネティックス;細胞初期化;Py-Imポリアミド;DNAナノ構造体;遺伝子発現;初期化;エピジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24225005/
• An integrated approach for mapping RNA protein interactions in the ribosome

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  ナマシヴァヤム パンディアン

  From 30 Jun. 2022, To 31 Mar. 2024, Granted

  Nanopore;Direct RNA sequencing;RNA-protein interactions;Chemical probe;Machine learning;ナノポアシークエンシング;リボソーム;RNA-たんぱく質相互作用;ケミカルプローブ;バイオインフォマティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19291/
• Development of transcription therapy for skin cell rejuvenation using design-on-demand artificial transcription factors

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  ナマシヴァヤム パンディアン

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ミトコンドリア;転写療法;活性酸素種;皮膚細胞の若返り;エピジェネティックコード

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02607/
• Development of transcription therapy for skin cell rejuvenation using design-on-demand artificial transcription factors

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  ナマシヴァヤム パンディアン

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ミトコンドリア;転写療法;活性酸素種;皮膚細胞の若返り;エピジェネティックコード

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27298/
• Development of transcription therapy for skin cell rejuvenation using design-on-demand artificial transcription factors

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  ナマシヴァヤム パンディアン

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ミトコンドリア;転写療法;活性酸素種;皮膚細胞の若返り;エピジェネティックコード

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27298/
• An integrated approach for mapping RNA protein interactions in the ribosome

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  Ganesh Pandian NAMASIVAYAM

  From 30 Jun. 2022, To 31 Mar. 2024, Project Closed

  Transcriptomics;RNA Structures;Nanopore technology;Chemical probes;Informatics;RNA protein interactions;RNA modifications;ナノポアシークエンシング;リボソーム;RNA-たんぱく質相互作用;ケミカルプローブ;バイオインフォマティクス;Nanopore;Direct RNA sequencing;RNA-protein interactions;Chemical probe;Machine learning

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19291/
• Development of molecules that control gene networks and their application to cells

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  Hiroshi SUGIYAMA

  From 05 Apr. 2021, To 31 Mar. 2024, Project Closed

  ケミカルバイオロジー;生物有機化学;遺伝子発現制御;ヌクレオソーム;DNAナノ構造体;AFM解析;ミトコンドリア;遺伝子発現

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04705/

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  Frontiers in the Field of Chemical Biology and Biological Chemistry

  H409, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Nano-Biosensors and Smart Biomaterials

  H429, Fall, Graduate School of Engineering, 1.5

Administration

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  高等研究院物質―細胞統合システム拠点主任研究者会議 議長

Academic, Social Contribution

Committee Memberships

• From Apr. 2019, To Present

  Asian Chemical Biology Initiative, Sub-member
• From Sep. 2017, To Present

  World Mitochondria Society
• From Apr. 2017, To Present

  KINKA CHEMICAL SOCIETY
• From Oct. 2011, To Present

  Nucleic Acids Chemistry

Academic Contribution

• SPIRITS International Symposium – 2018, “Multi-disciplinary Approaches for Cell Control”

  Planning, management, etc.

  
• SPIRITS International Symposium – 2019, “Regulation of Cell Fate and Disease Treatment”

  Planning, management, etc.