基本情報

協力講座

• 工学研究科, 分子工学専攻（細孔物理化学分野）分子材料科学講座, 講師

学位

• Ｍ．Ｓ．（生物工学）(マドラス大学)
• 博士（学術）(新潟大学)

経歴

• 自 2018年10月, 至 現在

  Rutgers University, 米国, KiBum Lab, 客員研究員
• 自 2018年08月, 至 現在

  Kyoto University, iCeMS, 主任研究者
• 自 2018年07月, 至 現在

  京都大学, iCeMS, 講師(終身雇用)
• 自 2018年03月, 至 現在

  AO Research Institute, スイス, Department of Musculoskeletal Regeneration, 客員研究員
• 自 2016年03月, 至 2018年06月

  京都大学, iCeMS, 助教(終身雇用)
• 自 2014年03月, 至 2016年02月

  Kyoto University, iCeMS, Program-Specific Research Center Assistant Professor
• 自 2010年01月, 至 2014年02月

  Kyoto University, iCeMS, Research Associate
• 自 2009年04月, 至 2010年01月

  Niigata University, Hori Lab, Division of Applied Biosciences, Research Assistant Professor
• 自 2009年10月, 至 2009年12月

  Ushiki and Associates Patent Office, Niigata Office, Visiting Scientific Advisor
• 自 2003年10月, 至 2006年01月

  Indian Institute of Technology-Madras (IIT‐M), Department of Biotechnology, Project Associate
• 自 2004年11月, 至 2005年10月

  Kelvin Chemicsls, Chennai Branch, Visiting Scientist
• 自 2002年06月, 至 2003年10月

  Indian Institute of Technology-Madras (IIT‐M), Department of Chemistry, Research Assistant

ID,URL

• ORCID ID

  0000-0002-5531-1995

• J-Global ID

  201401089727002803

• 研究者番号

  20625446

• 外部リンク

  https://www.namasivayam.icems.kyoto-u.ac.jp/

researchmap URL

• https://researchmap.jp/7000008872

研究

研究テーマ・研究概要

• 研究テーマ

  Small Molecules to control cell fate

• 研究概要

  Natural epigenetic processes precisely orchestrate the intricate gene network by switching “ON” and “OFF” the genes at the right place and time to regulate cellular homeostasis and phenotype. Epigenetic enzymes like histone deacetylases (HDACs) and histone acetyltransferases (HATs) organize histone acetylation and chromatin architecture to govern endogenous gene expression. Pathological chromatin alterations are inherently flexible and can be reversed through pharmacological intervention. HDAC inhibiting small molecules like suberoylanilide hydroxamic acid (SAHA) have been harnessed to modulate gene expression. However, they operate in a sequence-independent manner (Biotechnol. J., 2012, 7, 798). Taking cues from natural transcription factors, we developed a novel class of compound termed, SAHA-PIP containing sequence-specific pyrrole-imidazole polyamides (PIPs) and SAHA. Screening studies in mouse embryonic fibroblasts (MEFs) showed that certain SAHA-PIPs triggered epigenetic marks associated with transcriptionally permissive chromatin and differentially activated the pluripotency genes like Oct-3/4, Sox2, Klf4 and c-Myc (ChemBioChem., 2011, 12, 2822). Genome-wide gene analysis revealed a SAHA-PIP termed `δ` could multiple pluripotency genes in MEF by more than ten-fold to initiate cellular reprogramming in just 24 h (Sci. Rep., 2012, 2, e544).
  
  Evaluation of the effect of SAHA-PIPs on genome-wide gene expression in human dermal fibroblasts (HDFs) divulged that each SAHA-PIP could differentially activate the therapeutically important genes like anti-HIV MX2 and anti-obesity KSR2 (Sci. Rep., 2014, 4, e3843). Among them, the notable `ON` switching SAHA-PIPs in HDFs include `K` for germ cell-associated PIWI pathway genes (Angew. Chem. Int. Ed. 2013, 124, 13652 [HOT PAPER]) and `I` for pluripotency-associated OCT4 pathway genes (ACS Chem. Biol. 2014, 9, 2729). Conjugation of DNA binding domain of `I` with HAT activating N- (4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide (CTB) remarkably activated identical cluster of genes as SAHA-PIP `I` to substantiate the role of PIP in sequence-specific gene regulation (Angew. Chem. Int. Ed. 2015, 54, 8700). Since PIP conjugates can be tailored to bind predetermined DNA sequences, strategies to expand DNA-based epigenetic switches could create an epoch-making approach in cellular reprogramming and therapeutic gene regulation.

研究キーワード

• ナノテクノロジー
• エピジェネティクス
• 細胞リプログラミング
• Bio-inspired therapeutics
• 人工遺伝子スイッチ

研究分野

• ナノテク・材料, ケミカルバイオロジー
• ライフサイエンス, ゲノム生物学, 遺伝子発現制御
• ライフサイエンス, 生体材料学, Nature-inspired Biomaterials
• ライフサイエンス, 生体医工学, Nature-inspired Biomaterials

論文

• Creation of Metal-Complex-Integrated Tensegrity Triangle DNA Crystals

  Katsuhiko Abe; Haruhiko Eki; Yuki Hirose; Soyoung Park; Shanmugavel Chinnathambi; Ganesh Pandian Namasivayam; Kazuki Takeda; Hiroshi Sugiyama; Masayuki Endo

  Molecules, 2024年10月01日

  
• Clock-Sleep Communication

  Seithikurippu R. Pandi-Perumal; Sayan Paul; Konda Mani Saravanan; Ganesh Pandian Namasivayam; Saravana Babu Chidambaram

  Current Molecular Medicine, 2025年04月

  
• DNA Methylation Modification Patterns Identify Distinct Prognosis and Responses to Immunotherapy and Targeted Therapy in Renal Cell Carcinoma

  Dan Bai; Yan Cheng; Xiaolan Lu; Ganesh Pandian Namasivayam; Hiroshi Sugiyama

  Frontiers in Bioscience-Landmark, 2023年09月26日

  
• Surface charge-dependent cytokine production using near-infrared emitting silicon quantum dots

  Shanmugavel Chinnathambi; Naoto Shirahata; Pooria Lesani; Vaijayanthi Thangavel; Ganesh N. Pandian

  Scientific Reports, 2024年12月

  
• Waking Up the Sleep Field: An Overview on the Implications of Genetics and Bioinformatics of Sleep

  Seithikurippu R. Pandi-Perumal; Konda Mani Saravanan; Sayan Paul; Ganesh Pandian Namasivayam; Saravana Babu Chidambaram

  Molecular Biotechnology, 2024年05月

  
• Subcutaneous adipose tissue: Implications in dermatological diseases and beyond

  Reihane Ziadlou; Ganesh N. Pandian; Jürg Hafner; Cezmi A. Akdis; Georg Stingl; Emanual Maverakis; Marie‐Charlotte Brüggen

  Allergy, 2024年12月

  
• Bat-associated microbes: Opportunities and perils, an overview

  J. Dhivahar; Anutthaman Parthasarathy; Kathiravan Krishnan; Basavaraj S. Kovi; Ganesh N. Pandian

  Heliyon, 2023年12月

  
• MOFs for next-generation cancer therapeutics through a biophysical approach—a review

  Leon Bernet Shano; Subramani Karthikeyan; Lourdusamy John Kennedy; Shanmugavel Chinnathambi; Ganesh N. Pandian

  Frontiers in Bioengineering and Biotechnology, 2024年06月13日

  
• Biomass-derived carbon dots as fluorescent quantum probes to visualize and modulate inflammation

  Mahima Kumar; Shanmugavel Chinnathambi; Noremylia Bakhori; Norhidayah Abu; Fatemeh Etezadi; Vaijayanthi Thangavel; Daniel Packwood; Easan Sivaniah; Ganesh N. Pandian

  Scientific Reports, 2024年06月03日

  
• Chalcone derivatives' interaction with human serum albumin and cyclooxygenase-2

  Subramani Karthikeyan; Ayyavu Thirunarayanan; Leon Bernet Shano; Arasappan Hemamalini; Anandh Sundaramoorthy; Rajendiran Mangaiyarkarasi; Norhidayah Abu; Singaravelu Ganesan; Shanmugavel Chinnathambi; Ganesh N. Pandian

  RSC Advances, 2024年

  この論文にアクセスする：

  
• Nano–bio interaction between human immunoglobulin G and nontoxic, near-infrared emitting water-borne silicon quantum dot micelles

  Shanmugavel Chinnathambi; Naoto Shirahata; Mahima Kumar; Subramani Karthikeyan; Katsuhiko Abe; Vaijayanthi Thangavel; Ganesh N. Pandian

  RSC Advances, 2023年

  この論文にアクセスする：

  
• Nucleic acid‐based small molecules as targeted transcription therapeutics for immunoregulation

  Dan Bai; Reihane Ziadlou; Thangavel Vaijayanthi; Subramani Karthikeyan; Shanmugavel Chinnathambi; Anutthaman Parthasarathy; Li Cai; Marie‐Charlotte Brüggen; Hiroshi Sugiyama; Ganesh N. Pandian

  Allergy, 2023年12月06日

  
• Pyrrole–Imidazole Polyamides – A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs

  Thangavel Vaijayanthi; Ganesh N. Pandian; Hiroshi Sugiyama

  Advanced Therapeutics, 2023年07月

  
• A biophysical approach of cytarabine anticancer drug insights into human serum albumin and checkpoint kinase 1

  Rupavarshini, M.; Karthikeyan, S.; Anandh, S.; Ramamoorthi, A.; Ramakrishnamurthy, S.; Bharanidharan, G.; Aruna, P.; Mangaiyarkarasi, R.; Chinnathambi, S.; Pandian, G.N.; Ganesan, S.

  Results in Chemistry, 2023年

  
• Scientists Against War: A Plea to World Leaders for Better Governance

  Seithikurippu R. Pandi-Perumal; Velayudhan Mohan Kumar; Namasivayam Ganesh Pandian; Joop T. de Jong; Sudalaikannu Andiappan; Alexandru Corlateanu; Arehally Marappa Mahalaksmi; Saravana Babu Chidambaram; Ramasamy Rajesh Kumar; Chellamuthu Ramasubramanian; Sudhakar Sivasubramaniam; Alvhild Alette Bjørkum; JosAnn Cutajar; Michael Berk; Ilya Trakht; Anton Vrdoljak; Miguel Meira e Cruz; Harris A. Eyre; Janne Grønli; Dainiel P. Cardinali; Andreas Maercker; Willem A. C. M. van de Put; Jaswant Guzder; Bjørn Bjorvatn; Wietse A. Tol; Darío Acuña-Castroviejo; Marie Meudec; Charles M. Morin; Markku Partinen; Corrado Barbui; Mark J. D. Jordans; Mario H. Braakman; Christine Knaevelsrud; Ståle Pallesen; Marit Sijbrandij; Diego Andrés Golombek; Colin A. Espie; Pim Cuijpers; Hernán Andrés Marín Agudelo; Koos van der Velden; Bessel A. van der Kolk; Stevan E. Hobfoll; Walter L. J. M. Devillé; Michael Gradisar; Dieter Riemann; John Axelsson; Gloria Benítez-King; Robert D. Macy; Vitalii Poberezhets; Samuel Ratnajeevan Herbert Hoole; Rangaswamy Srinivasa Murthy; Thomas Hegemann; Andreas Heinz; Jane Salvage; Alexander C. McFarlane; Rob Keukens; Harendra de Silva; Cornelia Oestereich; Jochen Wilhelm; Michael von Cranach; Klaus Hoffmann; Matthias Klosinski; Dinesh Bhugra; Mary V. Seeman

  Sleep and Vigilance, 2022年06月

  
• Facile Synthesis of Hafnium Oxide Nanoparticle Decorated on Graphene Nanosheet and Its Photocatalytic Degradation of Organic Pollutants under UV-Light Irradiation

  Jayaraman, V.; Mahalingam, S.; Chinnathambi, S.; Pandian, G.N.; Prakasarao, A.; Ganesan, S.; Ramasamy, J.; Ayyaru, S.; Ahn, Y.-H.

  Applied Sciences (Switzerland), 2022年

  
• Nanoparticle-Based Artificial Mitochondrial DNA Transcription Regulator: MitoScript

  Yang, L.; Rathnam, C.; Hidaka, T.; Hou, Y.; Conklin, B.; Pandian, G.N.; Sugiyama, H.; Lee, K.-B.

  Nano Letters, 2022年

  
• Artificial intelligence in microbial natural product drug discovery: current and emerging role

  Vinodh J. Sahayasheela; Manendra B. Lankadasari; Vipin Mohan Dan; Syed G. Dastager; Ganesh N. Pandian; Hiroshi Sugiyama

  Natural Product Reports, 2022年

  この論文にアクセスする：

  
• Mitochondria and G-quadruplex evolution: an intertwined relationship

  Vinodh J. Sahayasheela; Zutao Yu; Takuya Hidaka; Ganesh N. Pandian; Hiroshi Sugiyama

  Trends in Genetics, 2023年01月

  この論文にアクセスする：

  
• Structural colour enhanced microfluidics.

  Detao Qin; Andrew H Gibbons; Masateru M Ito; Sangamithirai Subramanian Parimalam; Handong Jiang; H Enis Karahan; Behnam Ghalei; Daisuke Yamaguchi; Ganesh N Pandian; Easan Sivaniah

  Nature communications, 2022年05月19日

  この論文にアクセスする：

  
• An informatics approach to distinguish RNA modifications in nanopore direct RNA sequencing.

  Soundhar Ramasamy; Shubham Mishra; Surbhi Sharma; Sangamithirai Subramanian Parimalam; Thangavel Vaijayanthi; Yoto Fujita; Basavaraj Kovi; Hiroshi Sugiyama; Ganesh N Pandian

  Genomics, 2022年04月20日, 査読有り, 最終著者, 責任著者

  この論文にアクセスする：

  
• Classification of COVID-19 from chest x-ray images using deep features and correlation coefficient.

  Rahul Kumar; Ridhi Arora; Vipul Bansal; Vinodh J Sahayasheela; Himanshu Buckchash; Javed Imran; Narayanan Narayanan; Ganesh N Pandian; Balasubramanian Raman

  Multimedia tools and applications, 2022年03月28日

  
• Comparative analysis of mitochondrial genomes in different species reveals the evolution of G-quadruplexes

  Hiroshi Sugiyama; Vinodh Sahayasheela; Zutao Yu; Ganesh Pandian

  2021年12月01日, 責任著者

  
• AI-based diagnosis of COVID-19 patients using X-ray scans with stochastic ensemble of CNNs

  Ridhi Arora; Vipul Bansal; Himanshu Buckchash; Rahul Kumar; Vinodh J. Sahayasheela; Narayanan Narayanan; Ganesh N. Pandian; Balasubramanian Raman

  Physical and Engineering Sciences in Medicine, 2021年12月, 査読有り

  
• Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model

  Malinee, M.; Pandian, G.N.; Sugiyama, H.

  Cell Chemical Biology, 2022年, 査読有り, 責任著者

  この論文にアクセスする：

  
• Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation.

  Takuya Hidaka; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Hiroshi Sugiyama

  Cell chemical biology, 2021年08月24日, 査読有り, 責任著者

  
• Designing Biomimicking Synthetic Transcription Factors for Therapeutic Gene Modulation

  Ganesh N. Pandian; Hiroshi Sugiyama

  Cell-Inspired Materials and Engineering, 2021年, 査読有り, 責任著者

  
• Sequence-Specific Control of Using Programmable Synthetic Gene Switches Called MITO-PIPs

  Takuya Hidaka; Hiroshi Sugiyama; Ganesh N. Pandian

  Methods in Molecular Biology, 2021年, 査読有り, 最終著者, 責任著者

  
• Chemical probe-based Nanopore Sequencing to Selectively Assess the RNA modifications

  Soundhar Ramasamy; Vinodh J Sahayasheela; Zutao Yu; Takuya Hidaka; Li Cai; Hiroshi Sugiyama; Ganesh N. Pandian

  ACS Chemical Biology, 2020年05月20日, 最終著者, 責任著者

  
• Targeted epigenetic modulation using a DNA‐based histone deacetylase inhibitor enhances cardiomyogenesis in mouse embryonic stem cells

  Jin‐A Lee; Jieun An; Junichi Taniguchi; Gengo Kashiwazaki; Ganesh N. Pandian; Nazia Parveen; Tong Mook Kang; Hiroshi Sugiyama; Debojyoti De; Kyeong Kyu Kim

  Journal of Cellular Physiology, 2020年11月08日

  
• A Near-Infrared Fluorogenic Pyrrole–Imidazole Polyamide Probe for Live-Cell Imaging of Telomeres

  Yutaro Tsubono; Yusuke Kawamoto; Takuya Hidaka; Ganesh N Pandian; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  Journal of the American Chemical Society, 2020年09月21日, 査読有り, 責任著者

  
• Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract

  Nor Amira Khurshid Ahmed; Shern Kwok Lim; Ganesh Pandian; Hiroshi Sugiyama; Chong Yew Lee; Boon Yin Khoo; Kit Lam Chan

  Molecular Medicine Reports, 2020年09月02日, 査読有り

  
• Enhanced nuclear accumulation of pyrrole–imidazole polyamides by incorporation of the tri-arginine vector

  Takuya Hidaka; Yutaro Tsubono; Kaori Hashiya; Toshikazu Bando; Ganesh N. Pandian; Hiroshi Sugiyama

  Chemical Communications, 2020年09月, 査読有り

  
• Discovery of 3-(benzofuran-2-ylmethyl)-1H-indole derivatives as potential autophagy inducers in cervical cancer cells.

  Shaziyaparveen K Siddiqui; Vinodh J SahayaSheela; Srinivas Kolluru; Ganesh N Pandian; Thankayyan R Santhoshkumar; Vipin M Dan; Chepuri V Ramana

  Bioorganic & medicinal chemistry letters, 2020年07月23日, 査読有り

  
• Accurate Prediction of COVID-19 using Chest X-Ray Images through Deep Feature Learning model with SMOTE and Machine Learning Classifiers

  Rahul Kumar; Ridhi Arora; Vipul Bansal; Vinodh J Sahayasheela; Himanshu Buckchash; Javed Imran; Narayanan Narayanan; Ganesh N Pandian; Balasubramanian Raman

  2020年04月17日, 査読有り, 責任著者

  
• A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus.

  Zutao Yu; Mengting Ai; Soumen K Samanta; Fumitaka Hashiya; Junichi Taniguchi; Sefan Asamitsu; Shuji Ikeda; Kaori Hashiya; Toshikazu Bando; Ganesh N Pandian; Lyle Isaacs; Hiroshi Sugiyama

  Chemical communications (Cambridge, England), 2020年02月20日, 査読有り

  
• CGHF: A Computational Decision Support System for Glioma Classification Using Hybrid Radiomics- and Stationary Wavelet-Based Features.

  Rahul Kumar 0003; Ankur Gupta 0002; Harkirat Singh Arora; Ganesh Namasivayam Pandian; Balasubramanian Raman

  IEEE Access, 2020年, 査読有り

  
• Targeted suppression of metastasis regulatory transcription factor SOX2 in various cancer cell lines using a sequence-specific designer pyrrole–imidazole polyamide

  Madhu Malinee; Alok Kumar; Takuya Hidaka; Masanobu Horie; Kouichi Hasegawa; Ganesh N Pandian; Hiroshi Sugiyama

  Bioorganic & Medicinal Chemistry, 2019年12月, 査読有り

  
• Therapeutic gene regulation using pyrrole–imidazole polyamides

  Zutao Yu; Ganesh N. Pandian; Takuya Hidaka; Hiroshi Sugiyama

  Advanced Drug Delivery Reviews, 2019年07月, 査読有り

  
• Chemical control system of epigenetics

  T. Vaijayanthi; Ganesh N. Pandian; H. Sugiyama

  The Chemical Record - Wiley Online Library, 2018年10月, 査読有り

  
• Direct observation of H3‐H4 octasome by high‐speed AFM

  Ganesh Pandian

  Chemistry-A European Journal, 2018年08月08日, 査読有り

  
• Colloidal stability of lipid/protein-coated nanomaterials in salt and sucrose solutions.

  NAMASIVAYAM; Ganesh Pandian

  ChemistrySelect, 2018年07月, 査読有り

  
• Biomimetic Artificial Epigenetic Code for Targeted Acetylation of Histones

  Junichi Taniguchi; Yihong Feng; Ganesh N. Pandian; Fumitaka Hashiya; Takuya Hidaka; Kaori Hashiya; Soyoung Park; Toshikazu Bando; Shinji Ito; Hiroshi Sugiyama

  Journal of the American Chemical Society, 2018年06月13日, 査読有り

  この論文にアクセスする：

  
• Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation

  Yulei Wei; Ganesh N. Pandian; Zutao Yu; Tingting Zou; Yue Li; Jayant Darokar; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  ACS Omega, 2018年, 査読有り

  
• Low temperature carbonization of chicken manure to char and its effect on growth of Oryza sativa L. Koshihikari and Brassica rapa komatsuna

  Ishimori, T.; Takahashi, Y.; Sato, H.; Hassan, A.; Iwamoto, Y.; Pandian, G.N.; Hori, H.

  Euro-Mediterranean Journal for Environmental Integration, 2017年05月, 査読有り

  
• Creation of a Synthetic Ligand for Mitochondrial DNA Sequence Recognition and Promoter-Specific Transcription Suppression

  Hidaka, Takuya; Pandian, Ganesh N.; Taniguchi, Junichi; Nobeyama, Tomohiro; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  Journal of the American Chemical Society, 2017年, 査読有り

  
• Antiproliferative and apoptotic activities of sequence-specific histone acetyltransferase inhibitors

  Yu, Zutao; Taniguchi, Junichi; Wei, Yulei; Pandian, Ganesh N.; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  European Journal of Medicinal Chemistry, 2017年, 査読有り

  この論文にアクセスする：

  
• A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm

  Taniguchi, Junichi; Pandian, Ganesh N.; Hidaka, Takuya; Hashiya, Kaori; Bando, Toshikazu; Kim, Kyeong Kyu; Sugiyama, Hiroshi

  Nucleic Acids Research, 2017年, 査読有り

  この論文にアクセスする：

  
• Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B-2 to Duplex DNA

  Zou, Tingting; Kizaki, Seiichiro; Pandian, Ganesh N.; Sugiyama, Hiroshi

  Chemistry-a European Journal, 2016年, 査読有り

  この論文にアクセスする：

  
• Nature-Inspired Design of Smart Biomaterials Using the Chemical Biology of Nucleic Acids

  Pandian, Ganesh N.; Sugiyama, Hiroshi

  Bulletin of the Chemical Society of Japan, 2016年, 査読有り

  この論文にアクセスする：

  
• A Multi-target Small Molecule for Targeted Transcriptional Activation of Therapeutically Significant Nervous System Genes

  Wei, Yulei; Pandian, Ganesh N.; Zou, Tingting; Taniguchi, Junichi; Sato, Shinsuke; Kashiwazaki, Gengo; Vaijayanthi, Thangavel; Hidaka, Takuya; Bando, Toshikazu; Sugiyama, Hiroshi

  Chemistryopen, 2016年, 査読有り

  この論文にアクセスする：

  
• Red fluorescent gut proteins in the mulberry silkworm with immunomodulatory properties

  NAMASIVAYAM; Ganesh Pandian

  Trends in Entomology, 2016年, 査読有り

  
• Synthetic strategies to identify and regulate noncoding RNAs

  Ganesh N. Pandian; Junetha Syed; Hiroshi Sugiyama

  Long Noncoding RNAs Structures and Functions, 2015年01月01日, 査読有り

  
• Advancing Small-Molecule-Based Chemical Biology with Next-Generation Sequencing Technologies

  Anandhakumar, Chandran; Kizaki, Seiichiro; Bando, Toshikazu; Pandian, Ganesh N.; Sugiyama, Hiroshi

  Chembiochem, 2015年, 査読有り

  この論文にアクセスする：

  
• Integrating Epigenetic Modulators into NanoScript for Enhanced Chondrogenesis of Stem Cells

  Patel, Sahishnu; Pongkulapa, Thanapat; Yin, Perry T.; Pandian, Ganesh N.; Rathnam, Christopher; Bando, Toshikazu; Vaijayanthi, Thangavel; Sugiyama, Hiroshi; Lee, Ki-Bum

  Journal of the American Chemical Society, 2015年, 査読有り

  
• A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts

  Syed, Junetha; Chandran, Anandhakumar; Pandian, Ganesh N.; Taniguchi, Junichi; Sato, Shinsuke; Hashiya, Kaori; Kashiwazaki, Gengo; Bando, Toshikazu; Sugiyama, Hiroshi

  Chembiochem, 2015年, 査読有り

  この論文にアクセスする：

  
• A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network

  Han, Le; Pandian, Ganesh N.; Chandran, Anandhakumar; Sato, Shinsuke; Taniguchi, Junichi; Kashiwazaki, Gengo; Sawatani, Yoshito; Hashiya, Kaori; Bando, Toshikazu; Xu, Yufang; Qian, Xuhong; Sugiyama, Hiroshi

  Angewandte Chemie-International Edition, 2015年, 査読有り

  この論文にアクセスする：

  
• Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy against Pluripotency Genes in Mouse Fibroblasts

  Abhijit Saha; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Yusuke Kawamoto; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  CHEMMEDCHEM, 2014年10月, 査読有り

  この論文にアクセスする：

  
• Alteration of epigenetic program to recover memory and alleviate neurodegeneration: Prospects of multi-target molecules

  Ganesh N. Pandian; Rhys D. Taylor; Syed Junetha; Abhijit Saha; Chandran Anandhakumar; Thangavel Vaijayanthi; Hiroshi Sugiyama

  Biomaterials Science, 2014年08月, 査読有り

  この論文にアクセスする：

  
• Targeted editing of therapeutic genes using DNA-based transcriptional activators: Scope and challenges

  Ganesh N. Pandian; Hiroshi Sugiyama

  Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications, 2014年01月01日, 査読有り

  
• Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control.

  Pandian GN; Taniguchi J; Sugiyama H

  Clinical and translational medicine, 2014年, 査読有り

  
• Chemical Modification of a Synthetic Small Molecule Boosts Its Biological Efficacy against Pluripotency Genes in Mouse Fibroblasts

  Saha, Abhiji; Pandian; Ganesh N.; Sato, Shinsuke; Taniguchi, Junichi; Kawamoto, Yusuke; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  Chemmedchem, 2014年, 査読有り

  この論文にアクセスする：

  
• Targeted Suppression of EVI1 Oncogene Expression by Sequence-Specific Pyrrole-Imidazole Polyamide

  Syed, Junetha; Pandian, Ganesh N.; Sato, Shinsuke; Taniguchi, Junichi; Chandran, Anandhakumar; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi

  Chemistry & Biology, 2014年, 査読有り

  この論文にアクセスする：

  
• Identification of a Small Molecule That Turns ON the Pluripotency Gene Circuitry in Human Fibroblasts

  Pandian, Ganesh N.; Sato, Shinsuke; Anandhakumar, Chandran; Taniguchi, Junichi; Takashima, Kazuhiro; Syed, Junetha; Han, Le; Saha, Abhijit; Bando, Toshikazu; Nagase, Hiroki; Sugiyama, Hiroshi

  Acs Chemical Biology, 2014年, 査読有り

  
• Next-generation sequencing studies guide the design of pyrrole-imidazole polyamides with improved binding specificity by the addition of β-alanine.

  Anandhakumar C; Li Y; Kizaki S; Pandian GN; Hashiya K; Bando T; Sugiyama H

  Chembiochem : a European journal of chemical biology, 2014年, 査読有り

  この論文にアクセスする：

  
• Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts

  Pandian, Ganesh N.; Taniguchi, Junichi; Junetha, Syed; Sato, Shinsuke; Han, Le; Saha, Abhijit; AnandhaKumar, Chandran; Bando, Toshikazu; Nagase, Hiroki; Vaijayanthi, Thangavel; Taylor, Rhys D.; Sugiyama, Hiroshi

  Scientific Reports, 2014年, 査読有り

  この論文にアクセスする：

  
• A Synthetic Small Molecule for Targeted Transcriptional Activation of Germ Cell Genes in a Human Somatic Cell

  Le Han; Ganesh N. Pandian; Syed Junetha; Shinsuke Sato; Chandran Anandhakumar; Junichi Taniguchi; Abhijit Saha; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013年12月, 査読有り

  
• Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources

  Yan-Ling Wu; Ganesh N. Pandian; Yan-Ping Ding; Wen Zhang; Yoshimasa Tanaka; Hiroshi Sugiyama

  CHEMISTRY & BIOLOGY, 2013年11月, 査読有り

  
• Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach

  Shigeo Masuda; Jun Wu; Tomoaki Hishida; Ganesh N. Pandian; Hiroshi Sugiyama; Juan Carlos Izpisua Belmonte

  JOURNAL OF MOLECULAR CELL BIOLOGY, 2013年10月, 査読有り

  
• Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity

  Abhijit Saha; Ganesh N. Pandian; Shinsuke Sato; Junichi Taniguchi; Kaori Hashiya; Toshikazu Bando; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2013年07月, 査読有り

  
• Design of a new fluorescent probe: Pyrrole/imidazole hairpin polyamides with pyrene conjugation at their γ-turn

  T. Vaijayanthi; T. Bando; K. Hashiya; G.N. Pandian; H. Sugiyama

  Bioorganic and Medicinal Chemistry, 2013年02月, 査読有り

  この論文にアクセスする：

  
• GSM1289295: HDF_SAHA-PIP2_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013年, 査読有り

  
• GSM1289294: HDF_SAHA-PIP1_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013年, 査読有り

  
• GSM1289293: HDF_DMSO_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013年, 査読有り

  
• GSM1289292: HDF_SAHA_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013年, 査読有り

  
• GSM1289291: HDF_SAHA-PIP9_rep1

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  Gene Expression Omnibus, 2013年, 査読有り

  
• E-GEOD-53318.sdrf.txt

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53318.raw.1.zip

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53318.processed.1.zip

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53318.idf.txt

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53317.sdrf.txt

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53317.raw.2.zip

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53317.raw.1.zip

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53317.processed.1.zip

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53317.idf.txt

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53316.sdrf.txt

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53316.raw.1.zip

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53316.processed.1.zip

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013年, 査読有り

  
• E-GEOD-53316.idf.txt

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013年, 査読有り

  
• A-GEOD-17692.adf.txt

  Sugiyama Hiroshi; Taniguchi Junichi; Pandian Ganesh N

  ArrayExpress Archive, 2013年, 査読有り

  
• A-GEOD-17077.adf.txt

  Pandian Ganesh N; Taniguchi Junichi; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• A-GEOD-13497.adf.txt

  Taniguchi Junichi; Pandian Ganesh N; Sugiyama Hiroshi

  ArrayExpress Archive, 2013年, 査読有り

  
• Strategies to modulate heritable epigenetic defects in cellular machinery: Lessons from nature

  Ganesh N. Pandian; Hiroshi Sugiyama

  Pharmaceuticals, 2012年12月27日, 査読有り

  
• Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes

  Thangavel Vaijayanthi; Toshikazu Bando; Ganesh N. Pandian; Hiroshi Sugiyama

  CHEMBIOCHEM, 2012年10月, 査読有り

  
• A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts

  Ganesh N. Pandian; Yusuke Nakano; Shinsuke Sato; Hironobu Morinaga; Toshikazu Bando; Hiroki Nagase; Hiroshi Sugiyama

  SCIENTIFIC REPORTS, 2012年07月, 査読有り

  この論文にアクセスする：

  
• Programmable genetic switches to control transcriptional machinery of pluripotency

  Ganesh N. Pandian; Hiroshi Sugiyama

  BIOTECHNOLOGY JOURNAL, 2012年06月, 査読有り

  
• Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes

  Ganesh N. Pandian; Akimichi Ohtsuki; Toshikazu Bando; Shinsuke Sato; Kaori Hashiya; Hiroshi Sugiyama

  BIOORGANIC & MEDICINAL CHEMISTRY, 2012年04月, 査読有り

  この論文にアクセスする：

  
• Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N-Methylpyrrole-N-Methylimidazole Polyamide Conjugates

  Gengo Kashiwazaki; Toshikazu Bando; Tomofumi Yoshidome; Seiji Masui; Toshiki Takagaki; Kaori Hashiya; Ganesh N. Pandian; Junichi Yasuoka; Kazunari Akiyoshi; Hiroshi Sugiyama

  JOURNAL OF MEDICINAL CHEMISTRY, 2012年03月, 査読有り

  
• Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes in Mouse Embryonic Fibroblasts

  Ganesh N. Pandian; Ken-ichi Shinohara; Akimichi Ohtsuki; Yusuke Nakano; Minoshima Masafumi; Toshikazu Bando; Hiroki Nagase; Yasuhiro Yamada; Akira Watanabe; Naohiro Terada; Shinsuke Sato; Hironobu Morinaga; Hiroshi Sugiyama

  CHEMBIOCHEM, 2011年12月, 査読有り

  
• Midgut juice of Plutella xylostella highly resistant to Bacillus thuringiensis Cry1Ac contains a three times larger amount of glucosinolate sulfatase which binds to Cry1Ac compared to that of susceptible strain

  Takanori Yamazaki; Toshiki Ishikawa; Ganesh N. Pandian; Keiichi Okazaki; Kohsuke Haginoya; Yuka Tachikawa; Toshiaki Mitsui; Kazuhisa Miyamoto; Chanan Angusthanasombat; Hidetaka Hori

  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2011年10月, 査読有り

  
• Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-κB signaling pathways after streptozotocin-induced diabetes mellitus

  R.A. Thandavarayan; V.V. Giridharan; F.R. Sari; S. Arumugam; P.T. Veeraveedu; G.N. Pandian; S.S. Palaniyandi; M. Ma; K. Suzuki; N. Gurusamy; K. Watanabe

  Cellular Physiology and Biochemistry, 2011年, 査読有り

  
• Formation of Macromolecule Complex with Bacillus thuringiensis Cry1A Toxins and Chlorophyllide Binding 252-kDa Lipocalin-Like Protein Locating on Bombyx mori Midgut Membrane

  Ganesh N. Pandian; Toshiki Ishikawa; Thangavel Vaijayanthi; Delwar M. Hossain; Shuhei Yamamoto; Tadayuki Nishiumi; Chanan Angsuthanasombat; Kohsuke Haginoya; Toshiaki Mitsui; Hidetaka Hori

  JOURNAL OF MEMBRANE BIOLOGY, 2010年10月, 査読有り

  
• Investigation of physicochemical condition to stabilize phosphatidylcholine-liposome enclosing fluorescent calcein and its exploitation for analysis of pore formation with Cry1A toxins of Bacillus thuringiensis

  Kohsuke Haginoya; Vaijayanthi Thangavel; Ganesh N. Pandian; Kazuya Tomimoto; Yasuyuki Shitomi; Masaaki Azuma; Chanan Angsuthanasombat; Hidetaka Hori

  APPLIED ENTOMOLOGY AND ZOOLOGY, 2010年08月, 査読有り

  
• Novel applications of silicon and porous silicon based EISCAP biosensors

  Arun Mathew; Ganesh Pandian; Enakshi Bhattacharya; Anju Chadha

  PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 2009年06月, 査読有り

  
• Bombyx mori midgut membrane protein P252, which binds to Bacillus thuringiensis Cry1A, is a chlorophyllide-binding protein, and the resulting complex has antimicrobial activity

  Ganesh N. Pandian; Toshiki Ishikawa; Makoto Togashi; Yasuyuki Shitomi; Kohsuke Haginoya; Shuhei Yamamoto; Tadayuki Nishiumi; Hidetaka Hori

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2008年03月, 査読有り

  
• Characterization of a Cry1A and chlorophyllide-binding 252-kDa protein and its antimicrobial and physiological applications

  NAMASIVAYAM; Ganesh Pandian

  Proc. of International conference on Bacillus thuringiensis, 2007年, 査読有り

  
• Deracemisation of β-hydroxy esters using immobilised whole cells of Candida parapsilosis ATCC 7330: substrate specificity and mechanistic investigation

  S.K. Padhi; D. Titu; N.G. Pandian; A. Chadha

  Tetrahedron, 2006年05月, 査読有り

  
• Deracemisation of aryl substituted α-hydroxy esters using Candida parapsilosis ATCC 7330: Effect of substrate structure and mechanism

  B. Baskar; N.G. Pandian; K. Priya; A. Chadha

  Tetrahedron, 2005年12月, 査読有り

  
• Sensitive Silicon and Porous Silicon Triglyceride Biosensors.

  NAMASIVAYAM; Ganesh Pandian

  Proc. of Intl. Workshop on Physics of Semiconductor Devices, 2005年, 査読有り

  
• Screening, characterization and application of an indigenous lipase.

  NAMASIVAYAM; Ganesh Pandian

  Advanced Biotechnology, 2005年

  
• Synthesis of optically pure α-hydroxy esters: A biocatalytic approach.

  NAMASIVAYAM; Ganesh Pandian

  Advanced Biotechnology, 2005年

  
• Preparation of chiral synthons: Biocatalytic deracemisation of aryl α-hydroxy esters.

  NAMASIVAYAM; Ganesh Pandian

  Advanced Biotechnology, 2005年

  
• Biocatalytic deracemization: An efficient and simple strategy for preparation of chiral α- and β-hydroxy esters.

  NAMASIVAYAM; Ganesh Pandian

  Chemical Research in Chinese Universities, 2005年

  
• Asymmetric reduction of alkyl 2-oxo-4-arylbutanoates and -but-3-enoates by Candida parapsilosis ATCC 7330: assignment of the absolute configuration of ethyl 2-hydroxy-4-(p-methylphenyl)but-3-enoate by H-1 NMR

  B Baskar; NG Pandian; K Priya; A Chadha

  TETRAHEDRON-ASYMMETRY, 2004年12月, 査読有り

  
• Microbial deracemisation of aromatic β-hydroxy acid esters

  S.K. Padhi; N.G. Pandian; A. Chadha

  Journal of Molecular Catalysis B: Enzymatic, 2004年06月, 査読有り

  

講演・口頭発表等

• Programming synthetic molecular codes for bioengineering

  NAMASIVAYAM; Ganesh Pandian

  The Korean Society of Biotechnology and Bioengineering, 2018年10月10日, 招待有り

  
• Designer molecule to target and silence mitochondrial gene transcription

  NAMASIVAYAM; Ganesh Pandian

  8th World congress on Targeting Mitochondria, , Berlin Berlin, 2017年10月23日, 招待有り

  
• Nature-inspired smart genetic switches,

  NAMASIVAYAM; Ganesh Pandian

  7th Indian JSPS Alumni Association (IJAA) International Conference on Science and Technology: Future Challenges and Solutions (STFCS-2016), 2016年08月08日, 招待有り

  
• Therapeutic gene modulation using DNA-based transcriptional activators

  NAMASIVAYAM; Ganesh Pandian

  Asian International Symposium -Medicinal Chemistry in The 95th Annual Meeting of The Chemical Society of Japan, 2015年03月27日, 招待有り

  
• Therapeutic gene modulation using DNA-based transcriptional activators,

  NAMASIVAYAM; Ganesh Pandian

  Asian International Symposium -Medicinal Chemistry in The 95th Annual Meeting of The Chemical Society of Japan, 2015年03月26日, 招待有り

  
• Alteration of global gene expression in human somatic cells using DNA-based epigenetic switches

  NAMASIVAYAM; Ganesh Pandian

  ISSCR Regional Forum - Global control of stem cells, 2014年11月05日

  
• Bio-inspired genetic switches for therapeutic gene regulation

  NAMASIVAYAM; Ganesh Pandian

  Ki-Bum lee Lab, Rutgers University, 2014年07月21日, 招待有り

  
• Artificial genetic `ON` switch

  NAMASIVAYAM; Ganesh Pandian

  Rossi Lab, Harvard Medical School, 2014年07月18日, 招待有り

  
• Transcriptional regulation of silent developmental genes in somatic cells using DNA-based epigenetic switches

  NAMASIVAYAM; Ganesh Pandian

  Cell Symposia - Transcriptional regulation in development, 2014年07月13日

  
• Synthetic small molecules to distinctively trigger transcriptional activation of pluripotency and germ-cell genes in a somatic cell

  NAMASIVAYAM; Ganesh Pandian

  CiRA international symposium, 2014年01月16日

  
• DNA-based Epigenetic Switches to Control Cell Fate

  NAMASIVAYAM; Ganesh Pandian

  0th International Symposium on Nucleic Acid Chemistry, 2013年11月13日

  
• Induced pluripotent stem cells and Genetic switches

  NAMASIVAYAM; Ganesh Pandian

  Stem Cell Research Laboratory, 2013年09月21日, 招待有り

  
• Cellular reprogramming – A chemical approach

  NAMASIVAYAM; Ganesh Pandian

  Madurai Kamraj University, 2013年09月18日, 招待有り

  
• Cellular time machine: Back to the future

  NAMASIVAYAM; Ganesh Pandian

  Kalasalingam University, 2013年09月17日, 招待有り

  
• Genetic switches to control cellular time machine

  NAMASIVAYAM; Ganesh Pandian

  Lady Doak College, 2013年09月13日, 招待有り

  
• Novel chemical approach for cellular reprograming

  NAMASIVAYAM; Ganesh Pandian

  8th Annual Meeting of the Japanese Society for Chemical Biology, 2013年06月19日

  
• Targeting small molecules as transcriptional activators for selective induction of pluripotency genes in somatic fibroblasts

  NAMASIVAYAM; Ganesh Pandian

  RSC-iCeMS Joint International Symposium: Cell-Material Integration and Biomaterials Science, 2013年03月18日

  
• Artificial epigenetic switches to selectively reprogram the transcriptional machinery conferring to cell fate

  NAMASIVAYAM; Ganesh Pandian

  World Stem Cell Summit-2012, 2012年09月01日

  
• Synthetic genetic switches for selective induction of pluripotency in mouse and human fibroblasts

  NAMASIVAYAM; Ganesh Pandian

  4th annual symposium of Institute for integrated cell-material sciences, 2012年08月31日

  
• Artificial genetic switches to induce pluripotency in somatic cells through directed chromatin remodeling

  NAMASIVAYAM; Ganesh Pandian

  AAAS Science-Days of Molecular Medicine-2011, 2011年11月10日

  
• Synthetic transcription factors for stem cell control

  NAMASIVAYAM; Ganesh Pandian

  Heidelberg-Kyoto Joint Symposium "Crossing Boundaries: Stem Cells, Materials, and Mesoscopic Sciences”, 2011年07月21日

  

書籍等出版物

• Sequence-specific control of mitochondrial gene transcription using programmable synthetic gene switches called MITO-PIPs

  T. Hidaka; H. Sugiyama; Ganesh N. Pandian, 共著

  Methods in Molecular Biology, Springer Protocols. Mitochondrial Medicine, 2nd edition, V. Weissig, M. Edeas, Editors. Humana Press, Springer New York Heidelberg Dordrecht London, 2020年

  
• Synthetic strategies to identify and regulate noncoding RNAs in LONG NONCODING RNAs: Structures and Functions

  NAMASIVAYAM; Ganesh Pandian, 共著

  Springer Japan, 2015年06月, 査読無し

  
• Targeted editing of therapeutic genes using DNA-based transcriptional activators: Scope and Challenges in Chemical Biology of Nucleic Acids

  NAMASIVAYAM; Ganesh Pandian, 共著

  Springer Berlin Heidelberg, 2014年01月, 査読無し

  
• Designing biomimicking synthetic transcription factors for therapeutic gene modulation

  NAMASIVAYAM; Ganesh Pandian, 共著, Cell-inspired Materials and Engineering

  Springer, 査読無し

  

受賞

• 2010年10月01日

  2nd iCeMS retreat-2010, Best Poster and Excellence Award
• 2011年07月23日

  Heidelberg-Kyoto Joint Symposium-2011, Best Poster Award
• 2011年07月23日

  Biotechnology Journal, Heidelberg-Kyoto Joint Symposium-2011, Biotechnology Journal Special Prize
• 2011年11月12日

  AAAS "Science" Days of Molecular Medicine -2011 , Young Investigator Award and Best Abstract
• 2012年09月01日

  4th annual iCeMS retreat-2012, Spotlight Talk and Cross-Disciplinary Research Prize
• 2013年03月19日

  RSC-iCeMS Joint International Symposium-2013, Biomaterials Science Poster Award (First Prize)

メディア報道

• がん免疫治療、効果高める手法。

  日経産業新聞, 14ページ, 2021年09月19日, 新聞・雑誌

  
• 「ミトコンドリア活性化」京大が中分子化合物を開発 マウス生存率向上

  科学新聞 1ページ, 2021年09月17日, 新聞・雑誌

  
• ＜めざまし8＞京大発表 ミトコンドリアでがん免疫治療薬の効果UP

  関西テレビ, 2021年09月14日, テレビ・ラジオ番組

  
• がん免疫治療薬、有効性が向上、京都大教授ら、ミトコンドリア活性化で。

  日本経済新聞 9ページ, 2021年09月14日, 新聞・雑誌

  
• がん免疫療法効果増に期待 京大グループ 化合物開発

  京都新聞 29ページ, 2021年09月14日, 新聞・雑誌

  
• 京大、Ｔ細胞ミトコンドリア活性化 「オプジーボ」の効果向上

  日刊工業新聞 23ページ, 2021年09月14日, 新聞・雑誌

  
• オプジーボの効果高める化合物開発 ミトコンドリア活性化、京都大グループ

  京都新聞速報版, 2021年09月14日, 新聞・雑誌

  
• 京大、化合物で変異ミトコンドリアＤＮＡ減少 遺伝子治療に応用

  日刊工業新聞 33ページ, 2021年08月31日, 新聞・雑誌

  
• ＜やさしいニュース＞京都大学 難病のミトコンドリア病治療に可能性

  テレビ大阪, 2021年08月27日, テレビ・ラジオ番組

  

外部資金：科学研究費補助金

• 遺伝子ネットワークを制御する分子の開発と細胞への応用

  基盤研究(A)

  中区分37:生体分子化学およびその関連分野

  京都大学

  杉山 弘

  自 2021年04月05日, 至 2024年03月31日, 交付

  遺伝子発現制御;ミトコンドリア;AFM解析;ヌクレオソーム;DNAナノ構造体;遺伝子発現

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04705/
• 心筋症関連ミトコンドリア・核内遺伝子の協奏的制御を可能にする人工転写因子の開発

  基盤研究(B)

  小区分47010:薬系化学および創薬科学関連

  京都大学

  ナマシヴァヤム パンディアン

  自 2019年04月01日, 至 2022年03月31日, 完了

  Transcription therapy;Epigenetic codes;Mitochondria;Reactive Oxygen Species;Energy metabolism;Nanoparticle;Immunotherapy;Heteroplasmy;ピロールイミダゾールポリアミド;エピジェネティクス;人工転写因子;ナノテクノロジー;心筋症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03349/
• ナノ粒子ベース人工転写因子を用いた弓矢リプログラミング法による心筋細胞の誘導

  挑戦的萌芽研究

  京都大学

  ナマシヴァヤム パンディアン

  自 2016年04月01日, 至 2018年03月31日, 完了

  ピロールイミダゾールポリアミド;人工転写因子;金ナノ粒子;分化誘導;遺伝子・核酸工学材料;遺伝子制御分子;細胞リプログラミング;心筋細胞;ミトコンドリア;人工ヒストンコード;ナノテクノロジー;リプログラミング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K12896/
• 治療に有効な遺伝子を制御する自然を模倣した革新的小分子化合物

  挑戦的萌芽研究

  京都大学

  ナマシヴァヤム パンディアン

  自 2014年04月01日, 至 2015年03月31日, 完了

  天然分子を模倣した化合物;DNAベースの治療;遺伝子発現制御;マルチターゲットな小分子化合物;エピゲノム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670055/
• 多能性に関する転写機構をオンにするプログラム可能な小分子の開発

  若手研究(B)

  京都大学

  ナマシヴァヤム パンディアン

  自 2012年04月01日, 至 2014年03月31日, 完了

  人工遺伝子スイッチ;細胞リプログラミング;小分子;合成生物学;iPS細胞;人口遺伝子スイッチ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24710261/
• 分子科学的アプローチによる遺伝子発現の制御と機構の解明

  基盤研究(S)

  京都大学

  杉山 弘

  自 2012年05月31日, 至 2017年03月31日, 完了

  遺伝子発現制御;エピジェネティックス;細胞初期化;Py-Imポリアミド;DNAナノ構造体;遺伝子発現;初期化;エピジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24225005/
• リボソームにおけるRNAタンパク質相互作用をマッピングするための統合的アプローチ

  挑戦的研究(萌芽)

  中区分43:分子レベルから細胞レベルの生物学およびその関連分野

  京都大学

  ナマシヴァヤム パンディアン

  自 2022年06月30日, 至 2024年03月31日, 交付

  Nanopore;Direct RNA sequencing;RNA-protein interactions;Chemical probe;Machine learning;ナノポアシークエンシング;リボソーム;RNA-たんぱく質相互作用;ケミカルプローブ;バイオインフォマティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19291/
• オンデマンド設計人工転写因子を用いた皮膚細胞の若返りのための転写療法の開発

  基盤研究(B)

  小区分47010:薬系化学および創薬科学関連

  京都大学

  ナマシヴァヤム パンディアン

  自 2023年04月01日, 至 2026年03月31日, 交付

  ミトコンドリア;転写療法;活性酸素種;皮膚細胞の若返り;エピジェネティックコード

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02607/
• オンデマンド設計人工転写因子を用いた皮膚細胞の若返りのための転写療法の開発

  基盤研究(B)

  小区分47010:薬系化学および創薬科学関連

  京都大学

  ナマシヴァヤム パンディアン

  自 2023年04月01日, 至 2026年03月31日, 交付

  ミトコンドリア;転写療法;活性酸素種;皮膚細胞の若返り;エピジェネティックコード

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27298/

教育

担当科目

• 自 2023年04月01日, 至 2024年03月31日

  化学から生物へ生物から化学へ

  H409, 後期, 工学研究科, 1.5
• 自 2023年04月01日, 至 2024年03月31日

  Molecular Nano-Biosensors and Smart Biomaterials

  H429, 後期, 工学研究科, 1.5

大学運営

部局運営(役職等)

• 自 2024年04月01日, 至 2025年03月31日

  高等研究院物質―細胞統合システム拠点主任研究者会議 議長

学術・社会貢献

委員歴

• 自 2019年04月, 至 現在

  Asian Chemical Biology Initiative, Sub-member
• 自 2017年09月, 至 現在

  World Mitochondria Society
• 自 2017年04月, 至 現在

  KINKA CHEMICAL SOCIETY
• 自 2011年10月, 至 現在

  Nucleic Acids Chemistry

学術貢献活動

• SPIRITS International Symposium – 2018, “Multi-disciplinary Approaches for Cell Control”

  企画立案・運営等

  
• SPIRITS International Symposium – 2019, “Regulation of Cell Fate and Disease Treatment”

  企画立案・運営等